Colocynthis

Volume II — Main text

COLOCYNTHIS . Citrullas Colocynthis, Schrad. Bitter apple or cucumber. Nat. Ord., Cucurbitacea. I. Provings.- I . HAHNEMANN, Materia Medica Pura, vol. vi of original, vol. i of translation. Contains 26 symptoms from self, 195 from 6 fellow-provers, and 29 from authors. 2. IBID., Chronic Diseases, Part 3 of original, vol. of translation . Contains a few additional symptoms only, from self. 3. Dr. ARNETH, æt. 25, choleric temp., strong and healthy. a. In Nov., 1842, took increasing doses of tinct. up to 25 dr. from 1st to 13th, without result. On 14th and 15th took 45 dr. twice daily. From 16th to 23rd, without repeating medicine, had (contrary to habit) two pappy stools daily, with slight abdominal griping. Stools having become natural again on 24th and 25th, on 26th took at I p.m. 50 dr. Pappy stool that e. and next m., and abundant urination, were only results. 27th. -70 dr. At 11 a.m. increased urine, and on following d. there was griping in epigastrium after each meal, worse towards e., and pretty severe drawing in l. testicle for h. 29th.- 80 dr. at 2 p.m. Next m. furuncle on face, and on Dec. 2nd another on back. Both disappeared in a few d. b. All traces of former action of drug having disappeared, A- took, Dec. 7th, m. and e., 3j of 3rd (aqueous) dil. After it two pappy evacuations. 8th.-Repeated dose at bedtime ; had scarcely got into bed before he experienced in epigastrium more violent griping than from tinct., but without evacuation following. 9th.-Same dose m. and e. After each two pappy stools. From Ioth to 14th took daily 3j of 2nd dil. about noon. 11th.-Towards e. began irritability of larynx, and voice became rough and hoarse. 12th.-Besides these symptoms, distressing dryness of air passages, and on 2 next d. sensible and unpleasant fatigue in affected parts. Remarkable aggravation after each dose. Two pappy stools daily. Foregoing symptoms having subsided, 21st-23rd took twice daily same dose. For first 2d. only usual griping (lasting 4 d. more) and pappy stools. On n. of 22nd, in bed, drawing in r. shoulder. 23rd. In afternoon, violent drawing pain in all teeth (quite unprecedented) . 24th.-Besides the toothache (which

lasted all d.) in e. moderate tension of ant. sup. spinous process of 1. ilium, which next d. changed to violent drawing, extending to groin and upper third of inner aspect of thigh, pretty violent all d., and not disappearing till 26th ; with singular feeling of stiffness in 1. great toe. No toothache since n. of 24th. On 26th, 3j in e., and next d. at noon Ziss and in e. 3j of Ist dil. without result save for a slight conjunctival irritation not uncommon with him . c. From Dec. 27th to Jan. 6th great inclination to looseness, often 3 stools a d. On 9th (being quite well) and 2 following d. took at noon 3j of 4th dil. Soon after first dose violent eructations for h. Ioth. Drawing and tearing in r. shoulder-joint in m., lasting all d. Painful tension in 1. patella in e. 11th .-Pain in patella so considerable that walking was painful ; heat and swelling found there on undressing in e., with indistinct pulsation. Itching at anus all d.; stools natural. By 12th symptoms had disappeared ; and no result could be obtained from 5th dil. ( Œsterr. Zeitschr., i.) 4. Вӧнм, æt. 40, atoning for every error of diet by a violent fit of colic, took on several occasions small increasing doses of tinct. Up to 3 dr. no effect was noticed, but whenever dose exceeded this there came on after eating cutting in umbilical or hypogastric region, with tenesmus or fluid stool. On Oct. 3rd he took 12 dr. in forenoon. Soon afterwards slight colic in umbilical region ; little appetite at noon ; violent eructation after eating, cutting in hypogastrium, and fluid stool with tenesmus. Cutting and tenesmus lasted till in e. he got warm in bed. Slept well, and felt well on waking while in bed ; but soon after rising had fresh attack of umbilical colic and frequent eructations. On going out felt very weak ; had little appetite at noon ; fluid stool after eating, with discharge of flatus and painful feeling in abdomen whole afternoon, only removed (as before) on getting warm in bed. These symptoms were daily renewed till 13th, when, after cocculus taken as antidote, they rapidly disappeared. (Ibid.) 5. FLEISCHMANN, æt. 41, strong but gouty, took on 1st d. 5 dr. , and on 2nd d. 10 dr. without effect. On 3rd d. 15 dr.; violent griping in umbilical region all d., feeling of coldness in abdomen, looseness of bowels. These symptoms lasted with more or less intensity for several d., and he took no more for three weeks. Beginning then again with 10 dr., besides previous very troublesome symptoms he had discharge of blood from anus, which continued for more than a year afterwards, with violent sticking and burning pain in small of back and anus. Before this proving he had never had anal hæmorrhage. ( Ibid.) 6. FRÖHLICH, æt. 32, liable to furuncles on face, laryngeal catarrh, constipation, and hæmorrhoids. Nov. 21st.-Took 5 dr. at 6 a.m. and 10 dr. in e. without effect. 22nd.- 10 dr. in m., fasting. At 1.30 p.m. umbilical colic, with painful stitches in bladder, subsequently alternating with same in rectum, disappearing on discharge of flatus ; also transient headache, feeling as if temples were screwed into, with heaviness of eyelids without sleepiness. Symptoms disappeared after café noir. Copious urination during d., and one soft but not copious stool. 23rd.-Woke with slight griping round navel ; took 20 dr. , and inth. had loud rumbling and discharge of flatus ; griping round navel,

increasing after fruit ; stitches, transient in upper jaw, frequent in 1. flank and along outer border of 1. sole ; cramp-like drawing in r. calf. These symptoms lasted all d., and did not diminish after coffee. At 7 p.m., 20 dr. N. quiet, but all next d.( which was foggy) he felt uncomfortably chilly and had continual griping about navel. In e. very weak ; sacrum and lower limbs painful as after a forced march, and a tearing-sticking pain encircled r. inner malleolus. On e. of 24th took 20 dr. , and on following m. 25 dr. After some beer at II a.m. violent griping, coming on in paroxysms and only disappearing after dinner. In e.,40 dr. At 3 a.m. awoke by violent constrictive pain in umbilical region, lasting 15 m. No med. or symptoms till 28th and 29th, on which d. he took 40 dr. in m., fasting. In forenoon, griping and slight urging, both much increased after dinner till 4 p.m., with 2 stools, second having mucus in it. On 30th took 60 dr. in m. , fasting, and 40 in e. Same abdominal symptoms, but less marked ; in e., painful lassitude in sacrum and lower extremities ; flying stitches in humeri. Dec. Ist.-Pain in ankle while walking, as if from a false step, ceasing at rest ; feeling of stiffness in hands, continuing longer. 2nd-7th.-Stitches in ankle ; tearing in shoulder ; occasional deep stitch in l. flank ; weary feeling in sacrum and viscid soft scanty stool every 3 d. (Ibid.) 7. A young woman, slightly chlorotic, took April 29th 2 globules of 3rd dil. Soon, inodorous eructations and unusual discharge of flatus ; later, drawing-tearing pains in whole abdomen and in finger-joints of 1. hand. May Ist.-Three globules. Same eructations ; drawing in nape and dorsal muscles. 3rd.-Same ; pain in sacrum ; tearing drawing in both thighs and in l. arm down to finger-joints. 5th.-Fourgl. Drawing in 1. hypochondrium ; tearing in l. calf as far as heel. 9th.-Six gl. Stitches deep into abdomen ; tearing in joints of 1. hand. Similar doses, with similar effects, were taken every 3 or 4 d. till June 6th. Symptoms generally appeared 6-7 h. after dose, lasted 9-10 h ., and even manifested themselves slightly on followingd. (Ibid.) 8. A sister of the above took same dose, with corresponding effects. She had, however, more frequent isolated deep stitches as from a needle, sometimes in r. sometimes in 1. flank, apparently connected with ovaries . Neither experienced any other symptom connected with genital system. ( Ibid.) 9. Dr. GERSTEL, æt. 38, stout, full-blooded, in good health, save that he is liable to dyspeptic difficulties, cramp in stomach, and diarrhœa (after taking cold in feet), besides slight rheumatism, permanent palpitation, and moderate hæmorrhoidal bleeding every 4-8 weeks. a. Nov. 20th, at 4.30 p.m., took 15 dr. of tinct. I h. after a moderate dinner. A few m. after dose a slow stitch on r. beneath navel ; soon after on 1. of navel ; colic only perceptible when walking, disappearing when standing still or even when going downstairs, but returning on walking on a level ; drawing in upper r. teeth, with feeling as if upper lip was swollen ; constant ringing in r. ear ; slight inflation at epigastrium with pulsation in sacrum, ameliorated by emission of flatulence ; general hot flush, especially in face, with sweat on forehead ; constriction round middle of 1. leg as if from a narrow

ribbon ; free discharge of flatus. All these symptoms appeared within h. On 22nd took 25 dr. in m., fasting, but after usual stool. Soon after dose rumbling in abdomen and deep-seated pulsation in it, not perceptible to hand laid upon it ; sticking in pubic region ; transitory tickling itching on thigh, and same repeatedly in face,shoulders, flanks, as well as at extremity ofglans penis, with tendency to urinate ; feeling of numbness down outer side of r. calf as though in track of nerve, increasing to sensation as if nerve were swollen, passed into dull pressive constriction, and slowly disappeared ; soon after same feeling in great toes ; constrictive pressure in dorsum and ankle of 1. foot and in r. upper arm. All these symptoms appeared in course of I h. while lying in bed. Half an h. later griping in hypogastrium, going off in stitch towards 1. pubic region, with rumbling and sense of inflation ; immediately after, dulness of r. head, especially temple ; numbness of r. forearm ; dull stitches of 1. leg ; yawning ; lassitude ; copious urination. On 23rd, at 7 a.m., fasting, 40 dr. A tearing in 1. nape, experienced yesterday before taking drug, aggravated during its action and then entirely disappearing, becomes again excited ; sticking pressure in various parts of body ; some swelling of abdomen about navel, accompanied by slight dulness in forehead and temple ; sensitiveness of incisors ; unusual thirst ; burning in urethra after urinating ; burning and sore pain with moisture at anus as if after diarrhea, and stitches in rectum. At 11 p.m., just before going to bed, 23dr. Immediately, pressive pain in vertex and 1. eye ; colic with violent borborygmi ; copious discharge of flatus ; drawing twitching with dull throbbing in 1. iliac region, and in r. loin over crista ilii towards buttock; pressive pain on both eyeballs from above downwards ; burning of under lip ; prickling at end ofglans ; heat, especially in upper part of body. He fell asleep abouth. after dose. Once when he awoke in n. he felt unusual warmth over whole body, especially in upper limbs. 24th.- In m., soon after waking, sticking-drawing pains, now here, now there ; usual normal stool, soon followed by one of pappy consistence, and this by burning in anus, and at same time prickling in orifice of urethra after micturating. Towards noon, colic only when walking, disappearing every time he stood still ; pain, starting from upper abdomen, when more severe extended upwards towards chest, and then became constrictive, sensibly aggravated by any shock (as violent hawking) ; bowels painful on strong pressure on abdomen, as if excoriated ; unusual thirst ; another pappy stool. Soon after dinner, when walking in open air, oozing at anus and discharge ofmoisture from rectum instead ofexpected flatus ; oozing continued whole afternoon ; at 6 p.m. another pappy stool , with much mucus, and subsequent burning at anus. Soreness of abdomen continued all e., accompanied by thirst and early sleepiness. At n. very sound sleep. 25th.-Dulness of head early in m., especially in frontal region, with unusual weakness of memory. Normal evacuation. Frontal headache returned in forenoon when walking. Towards noon, after violent exercise, colic of yesterday returned, less violent, with dull pain in r. temple, aggravated by stooping, and gloomy mood. Finally, strong heat rising from abdomen towards chest, ending in partial sweat on abdomen and chest, with prickling at, and oozing from,

anus, and very copious urination. Some slight intimations of colic were perceived, principally about noon, on next 2 d. b. On Dec. 8th, 60 dr. at 7 a.m. He had had for 2 d. some catarrh , with swelling of r. ala nasi. Immediately after dose moderate epigastric pinching ; frequent empty eructations ; dryness, heat, and roughness in throat (continuingtill afternoon), with constant hemming ; dulness of 1. head, with pressive-burning pain in l. face and forehead, and feeling as if eye and nose were swelling (clearly marked and lasting) ; stitches above r. eye, with itching of scalp. Soon after breakfast, when walking rather rapidly, some vertigo ; frontal dulness ; constriction and pressure in l. cheek, extending into eye ; warmth in abdomen, increasing to griping and ending in sweat ; burning on tip of tongue, for several h.; slight burning and moisture at anus, after diarrhea ; prickling stitch like lightning from point ofglans through abdomen to 1. flank. Towards noon, while walking, some colic with inflation (clothes tight). Immediately after dinner, pappy stool, with horripilation over head and back ; soon after, while lying down, pain and rumbling in abdomen, with urging to stool and general horripilation ; inth. watery stool with griping, followed by continued and almost irresistible tenesmus. He became exceedingly sensitive to the damp weather. Legs were unusually weak ; it was hard work going upstairs . On waking during n., tearing in 1. tibia and ankle. In m., empty eructations ; stool soft, pappy, leaving tickling in rectum ; subsequently sensation of ball as large as fist rising up in pharynx, with oppressed respiration. In afternoon, continued sensitiveness, and griping and commotion in abdomen for several h.; another pappy stool after eating, with subsequent burning at anus and cramp in l. calf. Exceedingly increased sexual impulse for several d. c. Dec. 26th.-80 dr. of tinct. at 5.30 a.m. In course of 7 h., while seated and quietly employed, he experienced empty eructations, sometimes amounting almost to sobbing ; nausea, with scraping in throat, former departing after drinking water ; frequently recurring sharp pinching at epigastrium, with slight frontal dulness ; constant roaring and throbbing in both ears, especially 1.; palpitations, and pulsation in whole body, most felt in back and l. chest; itching with smarting and burning at various spots, especially of 1. side ; prickling over r. cheek-bone, as if eruption would come out, and exceedingly painful sticking burning on edge of 1. upper eyelid ; sneezing ; pressing and dull throbbing in 1. temple, with similar sensation about 1. shoulder, and itching of scalp ; toothache on 1. side, with twitching extending into 1. arm as far as elbow ; pressure on temple grew gradually acute and cutting ; troublesome pressure on 1. scalp, increased by turning, as in rheumatism ; aching in l. sacro- iliac commissure, with formication in l. sole, afterwards in r.; paralytic pressure in whole 1. arm, and fine shooting in skin in back of hand ; persistent pressure in r. malar bone and eye ; heat and swelled feeling in roots of r. lower teeth, similar sense of swelling in arms ; heaviness and oppression in sinciput ; intimations of vertigo and nausea ; burning on dorsum of tongue ; urgency to micturate. Immediately on taking only a few steps into room, pain in bowels and excitement of r. toothache ; on sitting down again,

pressing inwards and dull throbbing in r. lumbar region ; palpitation ; feeling in r. foot as if asleep ; pulsation in 1. popliteal space ; rumbling in abdomen ; flying pains in 1. side of epigastrium ; burning at anus. Subsequently, constant crawling and itching on whole 1. side of head ; continuance of r. toothache ; dulness in forehead ; feeling of warmth in r. ear ; burning on fore part of tongue ; burning and feeling of swelling in under lip ; scraping and burning in throat and hard palate (as from pepper) ; frequent erections. After 5 h. urgent inclination to stool, almost irresistible, and-in quick succession-two loose motions, with sore pain in bowels, better on bending forward, worse when upright ; frequent yawning ; weariness of thighs, especially noticed when going upstairs ; legs feel as if asleep ; moisture at anus and perinæum . Burning pain at stomach, even when eating ; chills after eating, especially in upper arms, and repeated yawning. Pain in stomach and tongue, and eructation, continued all d. and grew worse towards e., when another yellow, pappy stool took place, with griping ; abdomen continued tender and inflated even after the evacuation ; little appetite at noon, none in e.; frequent micturition. 27th.-In m., pressive spasmodic pain in stomach, rising into throat ; sense as of foreign body in throat, as though he had to swallow over a lump ; pappy, but otherwise normal, stool. Burning on tongue and eructations continued all d., but less intense ; moisture in perinæum all forenoon ; want of appetite in e. , with nausea and malaise after eating ; sleep disturbed by frequent waking. 28th.-Better feeling and appetite at first ; towards e., burning in tongue and stomach again ; empty eructations, causing burning in pharynx ; twitching in 1. 5th and 6th ribs ; in all upper teeth fine shooting and drawing, varying in intensity, with aching in 1. orbit, and same peppery sensation in mouth. Subsequently, sensation as of a coil in stomach and pharynx ; sobbing eructations ; salt taste of mucus hawked up ; burning in stomach ; pressing in abdomen ; discharge of much flatus ; prickling and crawling on different parts of body ; feeling of numbness, swelling and heat in l. foot, gradually invading whole leg, with itching and tickling, and lasting some time ; pressing throbbing pain at inner and upper part of 1. leg, extending along back of thigh to ischium (when sitting and walking). 31st.- The scalded feeling at tip of tongue, gastric troubles, occasional eructations, diminished appetite and depression of spirits have continued, with e. exacerbations. To them was added a frequently-repeated throbbing, finally twitching pain in r. upper arm at insertion ofdeltoid, whence it extended through shoulder towards upper teeth, and as far as temple and vertex ; pain seemed in periosteum, and after its frequent recurrence arm there became sore to pressure. Every exacerbation, without exception, began with burning at apex of tongue. The gastric pains were always accompanied by pains in face and teeth. It was particularly observed that the symptoms appeared in groups, and were aggravated in e. and 10. during a. Dr.rest. (Ibid.) began, Nov. 8th, with 30 dr. of tinct. HAUSMANN After 6 h ., symptoms appeared in following order :-continual tensive pain in bowels which feel as if they had been gathered into a ball, had fallen down, and now lay like a pressive weight in hypogastrium, with

also sense as if anterior wall of abdomen were wanting, and bowels would fall out forwards ; occasional urging at anus as though a quantity of fæces were about to be discharged,with escape ofonly a little fluid mucus ; diffusion ofpleasant warmth, which seemed to deprive limbs of strength ; weakness of all joints, especially knees and elbows ; disinclination to bodily or mental exertion, even to visiting his dearest friend ; pressing pain in r. hypochondrium, at arch of diaghragm, oppressing breathing. Nothing being felt on 9th, on 10th H. took 3ss at 12.30 p.m. In h. sudden violent pressure on bladder, which was full, passing off as rapidly on emissions of abundant flatus in rapid succession, driving before them some mucous fluid. These emissions of wind frequently recurred in midst of following symptoms :-noises as from breaking of large bubbles in various parts of abdomen ; frequent urging towards anal sphincter which caused at once an escape of slightest quantity of wind or mucus ; pressure and tension at occiput, worst at inferior lateral protuberances . 11th.- Very slippery, soft stool about 11 a.m., tensive pressure over whole forehead during its evacuation. Same symptoms as before, p.m., vesical alternating with rectal tenesmus ; finally, entire relaxation for an h., during which he was incapable of bodily or mental exertion. Spasmodic yawnings occur continually. 12th.-About middle of forenoon both last symptoms return. Sudden shock (from behind forwards) through hepatic region and then through head. Sensation at anus, as if successive slippery bubbles were escaping ; and while walking discharge of much flatulence, causing rectum to vibrate. 14th.-Took a.m. 3) of tinct. At noon, after continual gentle urging and much easy flatus, a rapidly passing stool. At I p.m. pressive pain in 1. forehead, occasionally slightly vibrating, along edge of frontal sinus. Towards 4, first griping about navel, subsiding, then returning as cutting as if from chisel thrust deep into abdomen,thence curving into pelvis, and finally cutting its way up again. Cutting continued in hypogastrium at intervals, relieved occasionally by passage ofwind or mucus, till towards 5, after a very painful pressure, a quantity of thin bland fæces passed involuntarily at a single impulse, and thereupon pains in abdomen all disappeared. In e., while in society, violent long-continued pressure on both sides of occiput. At n., much pleasant dreaming. Pressure and weight in 1. forehead on waking in n. , 1. eyelid feeling thick and heavy ; slight pulsation in l. hypochondrium. Next d., head befogged, difficulty in collecting thoughts, no interest in things. Slight exertion caused fatigue and made him perspire ; morbidly sensitive to open air. Easy stool p.m.; frequent flatus as before. 16th . While walking, drawing and tension within r. knee, several times ; painful tension in r. shoulder on first walking, continuing and becoming worse from moving arm ; at one time tensive and pressive pain at attachmentofdiaphragm, both sides. 17th.-Mist before r. eye in m., lasting several h., not removed by rubbing it. 18th.- Frequent, loud, and long-continued ringing in ears ; sexual impulse highly excited. 19th .-At 10 a.m., shimmering before r. eye, in shape of circle with rays, pressure in ball in e., upwards and outwards, aggravated by rubbing with finger, ball feeling harder than natural. This lasted some d.

b. June 7th, 1863, at I p.m. took 100 dr. of a very concentrated tinct. From 6 p.m. he had several attacks, at short intervals, of umbilical colic, followed by liquid stool, with much tenesmus, sphincter seeming paralysed. On endeavouring to repress urging pressive tension came on in hypogastric parietes, and acute aching at angle of r. scapula, with tensive pain from thence downwards. At one time a great, white, very bright light came at side of and below line of vision of r. eye ; but as he turned eyes sideways to see it, it vanished. (Ibid.) 11. Dr. MASCHAUER, æt. 28, took from 7th to 14th Nov., 1863, doses of 5-20 dr. of tinct. without effect, save usual colic and diarrhea, and some constriction of, and stitches in, chest. Doses of 15-25 dr., from 20th- 25th, did no more. On 26th he took 30 dr. After 6 h . violent griping and cutting about navel, increasing from h. to h.; abdomen tense, inflated, painfully sensitive to touch ; some diminution of pains after 2 watery stools. During n. great restlessness and sensibility of abdomen, so that it could hardly bear lightest pressure : this continued next d. Increasing doses of 1x were then taken for 14 d., but without result. (Ibid. ) 12. Dr. PUFFER took for 6 d. in succession, about noon, 4 or 5 dr. of tinct. Immediately after dose bitter taste and eructations ; I h. later rumbling in bowels. and disturbance as if diarrhea were about to come on, with discharge, however, only of fœtid flatus. Subsequent stool was hard and insufficient. On one occasion stool, at first knotty and dry, was later diarrheic. Sleep was broken by lively dreams and frequent call to micturate ; urine remarkably increased. (Ibid.) 13. a. Dr. REISINGER, æt. 30., strong and healthy. Nov. 3rd, 4th, and 5th, took 10 dr. of tinct. m. and e. without effect save on e. of 5th and following d. stiffness of r. forearm with painfulness of extensor muscles. 6th.- 15 dr. in m. After 5 h. flatulence and a soft stool, with colic, rather aggravated after evacuation, and accompanied by chilly feeling over whole body: 7th- 11th.- 15 dr. on Ist d., and 20 dr. on others, were followed by nothing but eructations, griping, and flatulence. 12th.- 25 dr. followed in 5 h. by 3 loose stools, and colic lasting throughout d. 13th.- 26 dr. in m. Towards noon slight drawing in r. upper arm, remarkably increasing after dinner, and becoming almost painful, but decreasing again when walking in open air. 14th .- 15 dr. Same drawing all d.; towards e. griping and loose stool, with burning at anus, also cold feeling of whole body, followed by heat without thirst. Drawing continued into next forenoon. b. On 19th and 20th, in m., took 5 gr. of I, trit. No symptoms on 19th, but on 20th nausea, empty eructations and pinching in abdomen, with accompanying transient headache in l. forehead. ( Ibid.) 14. a. Dr. RoTHANSL took, Nov. 2nd, 3rd, and 4th, 4, 5, and 12 drops of tinct. without effect. On 5th, 14 dr. Pressing in scrobiculus and constriction of larynx, compelling frequent swallowing. 6th.- 16 dr. Same pressure in forehead and root of nose, as if catarrh were coming on (for 3 h.). On 7th, 8th, and 9th, 18 dr. each d. On last d. disturbance in abdomen and three pappy stools, with feeling of coldness in whole body. On 12th, 13th, and 14th 20 dr., without effect. On 19th, 15 dr.; violent colic starting from umbilicus, with emissions

of flatus giving relief; this continued all n., and entirely deprived him of sleep. 20th.-Constriction of larynx, disappearing after h. in open air ; n . sleepless from cramp- like pressure in scrobiculus and constriction of stomach,-latter so sensitive that he could not endure pressure of lightest covering. Towards m. loud rumbling, and escape of flatus upwards and downwards, which relieves . Took 15 dr. a.m. Tensive headache in r. temple ; single flying stitches in r. flank. P.m. , cutting and rumbling in abdomen, with flatulent emissions (which relieve) ; diarrheic evacuations (so also on two following d.) . 24th .- 25 dr. Aching in both temples, in open air first worse, then entirely disappearing ; burning, while walking, along l. tibia ; constriction about umbilicus and in larynx. 25th.-30dr. Abdominal cutting immediately after eating, diarrhæic stool with tenesmus. 26th and 27th.-35 dr. each d. Same symptoms as before. Colic continued all n. of 27th and 28th, with extreme sensibility of abdomen ; general lassitude, with beaten feeling in sacrum on 29th, and pressive headache on m. of 30th. b. Dec. 5th and 6th.-3 dr. without effect. On most d. from 7th to 19th, 5 dr. 7th.-Great oppression of chest before midnight, driving away sleep ; after midnight restless sleep, with vivid troublesome dreams. 8th.-Early, pressive headache in temples and annoying twitching of r. upper eyelid (last continuing during 3 following d. ) . In e., pappy stool ; at n. slight spasm in stomach, rising along gullet to throat. 9th.-Sudden transient vertigo with darkness before eyes in e. while sitting down. 13th.-In m. in bed rumbling in abdomen and slight headache ; at noon, tensive pain in 1. thumb, impeding its motion . 14th.-Weight in both knees ; in e. tearing in l. knee, disappearing on walking. 15th.-Repeated tensive pain in l. thumb. 16th . In e. considerable headache, and unfitness for any kind of occupation. 17th .-Noon and e., slight colic after eating ; extremely restless sleep, with vivid nonsensical dreams ; troublesome oppression of chest. 18th.- In e. deadness in knees when stooping, so that it was difficult to get upright again ; n. very restless, full of dreams. 19th.-Drawing pains in r. thigh as far down as knee-a symptom which continued in nearly equal intensity for next 3 d. The intestinal canal was torpid during all this time, evacuations hard and occurring only every 2nd or 3rd d. 23rd.- In m. took 10 dr.; soon after dinner, rumbling in abdomen, constrictive pain in umbilical region, and a pappy stool ; during succeeding n. colicky pains, with emission of flatulence. 26th-28th.-Took 5 dr. each m. 26th.-Cutting abdominal pains after dinner and supper. 27th.-Headache and stitching in r. patella, from m. In e., rumbling and cutting in bowels, two pappy stools. 28th.-Stitching in patella returned, coming on when walking but going off on continuing to do so. The following two n. violent attacks of colic. Distinct colocynth symptoms were felt by prover for 4 d. after taking last dose-stitches in patella, frequent griping in abdomen, cramp in stomach at n., relieved by eructations, restless sleep, tossing about in bed. (Ibid. ) 15. a. Dr. WACHTEL, æt. 30, sound health, took Nov. 16th- 19th daily doses increasing 1-4 dr., with scarcely any effect. 20th.-5 dr. P.m., twitching at anus and thereafter two ordinary stools. 21st.- VOL. II . 23

5 dr. , with no special result save unwontedly copious urination. 22nd -24th.- 10 dr. each d. 22nd.-Soon after dose, pressing feeling in orbits, towards root of nose. P.m., feeling of heat in nape, burning and twitching in rectum and anus ; soon after, three fluid, mucous, but painless stools. 23rd.-Feeling of stiffness in muscles of nape on moving head ; after dinner flying stitches in hepatic region and sacrum ; in e. feeling of dryness in eyes. 24th.-A.m., urging to micturate, with discharge ofgreat quantity of clear watery urine (returning nearly every h.). P.m., confusion of head with pressure in orbits ; feeling of coldness through whole body, especially in knees (though room was warm enough) ; later, ineffectual urging in rectum, soon followed by itching in anus and orifice of urethra. In e., uneasiness and weakness of whole body, especially oflower extremities ; craving hunger, especially for bread and beer. 25th.-Took 15 dr. , and increased by 5 dr. each d. till 29th . Symptoms observed were : Confusion of head ; scraping in throat ; rumbling in abdomen ; constriction in umbilical region ; distended abdomen; feeling of emptiness and soreness of bowels ; pappy stools with burning at anus ; itching on various parts of body, obliging him to scratch ; flying stitches in hepatic region, sacrum, dorsum of r. foot, and great toe. b. Dec. 20th-28th.-Each m. took 10 gr. of I, trit. On 21st, only some pressure on forehead. 22nd.-Increased secretion of urine, and towards e. confusion ofhead. 23rd.-Flying drawing stitches as if in periosteum of bones of both forearms. 24th.-Scraping in throat about uvula. 25th.-Throat reddened, and swallowing difficult. 26th.-A true angina set in, for which belladonna, and subsequently lachesis was taken. Jan. 3rd.-After throat affections had subsided, began again with same dose, which he took daily till 15th. 3rd.- Frequent urging to stool, but no evacuation. 4th.-Taste of drug seemed to-day disgustingly bitter, and it continued all d. In e., stitching drawing along 1. tibia to ankle-bones, with at same time burning pressure in l. eye, both disappearing in 5-6 m. Later, a very hard evacuation, as if he were passing stones. 5th.- Pressure in both temples ; itching at several points on surface, causing constant restlessness, so that he can scarcely remain seated. At noon, beer tastes remarkably bitter. In e., when walking, sensation as if all strength were failing ; feeling of emptiness in stomach and thereupon voracious hunger. No stool all d. 6th.-Towards noon, violent cutting pain, like an electric shock, through whole abdomen to anus. Soon after, urging to stool, but without evacuation till an h. later, when it came away in pieces of stony hardness. P.m., flying stitches in r. chest from before backwards. During whole d., sensation as if tongue had been scalded (had same feeling in pharynx during angina). 7th.- Towards 3 p.m. feeling of weakness in whole body returned, but without subsequent voracious appetite. Towards e., flying drawings in extremities ; single needle-stitches under 1. pectoralis. No stool . 8th. The feeling in tongue recurred, but less severely. 9th.-Drawing aching in l. instep. At noon, extreme sleepiness. After dinner, stitching-cutting pain on r. instep, as if a nail were driven through . 10th.-Soreness ofscalp at vertex, as if on that spot hair were being

continually dragged up. 11th.-Feeling in scalp continues, and is accompanied by drawing-pressive pain in occiput. Both symptoms disappeared towards e. 13th.-Drawing stitching in joints of both insteps, lasting a m. , often recurring, and not interfering with walking. It was worse after coffee and wine, and accompanied by boring pains in bones of lower extremities. These pains lasted all next d. with inconsiderable remissions, but in less intensity ; upper extremities were similarly affected p.m. 15th.-Pressive pain in sacrum, diminished by movement. 16th.-Rheumatico-gouty pains came on more violently than ever before, sometimes in joints, sometimes in long bones of extremities, but were not lasting. P.m., drawing aching in both shoulders. 17th.-In e., in addition to pains, heat in head and palpitation, which continued next d. in less degree, and disappeared the d. after. 20th.- A.m., feeling of repletion in gastric region ; rumbling in abdomen, with great inflation ; violent colicky pains continuing for an h.,but disappearing after two evacuations following each other in quick succession. N. restless from flying stitches in hepatic region ; on following d. continuous pain in 1. knee-joint impeding walking. Up to Feb. 1st was still troubled with " rheumatic-gout in joints and long bones of extremities, of greater or less intensity at different times. (Ibid.) 16. a. Dr. WATZKE took, Nov. 3rd, at 8 a.m., 1 dr. of tinct. No symptoms save slight nausea towards noon. 4th.-4 dr. at 7 a.m. Head somewhat affected soon after dose. Towards 9, much rumbling in abdomen ; at noon, same intimations of nausea as yesterday ; restless n. with horrible exciting dreams. 5th.-7 dr. at 7 a.m. Towards 10, sense ofdistension in umbilical region with compression in throat and nausea. These symptoms lasted all d., and became worse some h. after dinner. Towards e., disgust before eating and inclination to vomit. 6th . -No symptoms save occasional slight drawings in scapulæ. 7th.- 15 dr. at 8 a.m. Frequent eructations soon followed, and towards noon 2 brown, thin, almost watery, painless stools. Nothing else. 8th- 11th .-Constant sensitiveness of umbilical region ; frequently-repeated long stitches in 1. chest and knee ; several pappy stools daily. 12th.-20 dr. soon after breakfast. A.m., acute pain in umbilical region, increased while walking ; later, transient drawing in r. shoulder ; towards e., stitches in l. side, arresting breathing ; drawing in scalp ; painful pressure in eyeballs, especially when stooping ; frequently returning stitches in r. elbow and forearm. During whole d. borborygmi and empty eructations. 14th.-In m., fasting, 95 dr. In 1 h. (immediately after breakfast) rising of bitter white frothy fluid ; violent unintermitting pain about umbilicus all forenoon, in spot about size of hand, a bruised pain, aggravated by walking, but not by pressure, and more tolerable after eructation ; therewith at times jerking stitches from navel to loins and spine ; intimations of nausea ; urging to stool (which could be repressed) . Towards II , constant burning pains in spot on r. chest ; feeling of roughness in throat ; pressure in both temples ; smarting in eyes ; painfulness of eyeballs ; excited fretful state of mind ; taciturnity. After dinner, abdominal pain worse, gnawing and boring, compelling him to sit, lie, or bend forward ; violent tenesmus came on, at first with pappy, copious, strong-smelling stools, which, an h. later, were watery,

scanty, yellowish, and almost inodorous. Twitching pains while walking in dorsa of both feet towards tibiæ. Colic diminished somewhat after café noir at 4, but became much worse again after supper, with confusion of head and frontal aching increased by stooping. Restless n. , vivid dreams, frequent waking (apparently produced by persistent painfulness of umbilical region) . 15th.-A.m., occasional stitching pains in r. chest ; two pappy, yellow, painless stools. In e. painfulness of whole head and eyes, very much aggravated by bending forwards ; constant colic with (repressible) urging to stool. N. very restless ; umbilical region unintermittingly painful ; profuse perspirations towards m. 16th. Colic (after moving about) more violent, gnawing, somewhat diminished towards noon, but not entirely remitting for whole d. P.m., frequent pressure on, and oppression of, chest, dull stitches in chest and sides. During whole d. sensitiveness of head, as though compressed, especially in sinciput and temples, with painfulness of eyeballs, aggravated by stooping, better in open air. 17th.-After quiet n. awaked in m. by griping in bowels and tenesmus, followed, however, by perfectly normal stool. Griping disappeared after black coffee, but returned in course of forenoon, accompanied by rumbling and movements in abdomen ; sensitiveness of head, pressure on temples and painfulness of eyeballs, came on again. Bruised pain in r. middle finger at noon ; after dinner, yellow, diarrheic stool, without tenesmus or pain In e. painfulness of umbilical region ; stitches in back ; spots on frert of thorax that were sore and painful, as if bruised. 28th.- " I am not yet free from effects of dose taken on 14th. I am constantly annoyed bya feeling as of a stoppage, a compression, a coil in the umbilical region, sometimes more, sometimes less. At times, especially towards m. , it increases to a piercing or cutting pain. I generally wake in m. with colic and tenesmus, and have every d. several thin pappy stools. I have frequent attacks of the painfulness and aching in sinciput and eyeballs, and the dull stitches in flank checking respiration. Since 24th I have perspired very profusely over whole body every n. towards m., and urine is of a faint flesh- redness, throws down a light-brown, flocky, irregular transparent sediment, and leaves on vessel small, hard, and rough reddish crystals, which adhere so strongly that they cannot be washed off. Umbilical pains were much alleviated, and head-troubles immediately disappeared, on supervention of these critical ' phenomena. " Dec Ist. -To-day for first time urine is bright again, but of a somewhat deep wine yellow, and containing a transparent cloud. Every abdominal symptom has now disappeared. 4th.-The morning sweats and cloudy reddish urine, with brown flocky mucous sediment, have returned for 2 d. past ; the pressing, sometimes gnawing pains about navel come on,especially in m. fasting ; movements and rumblings in bowels are often experienced. On e. of 3rd, gnawing pressive pain in inner ball of 1. foot, and painful stitches in cardiac region on going to bed. Ioth. Since 5th several little boils on hands, and stye in 1. eye, following usual course. Nothing else now, save feeling of tension and pressure in region of navel. On 18th, while writing, exceedingly painful, long stitches in r. metacarpus, frequently recurring in course of a few m., and embarrassing extension of hand and fingers. An h.

later, while reading, same symptoms recurred, only pain was more constant, stitches more intense and longer. Same symptoms (quite unprecedented) were repeatedly experienced curing following days. b. Proving with triturated pulp. Dec. 26th and 28th.-10 gr. of 3x, fasting, each m. Transitory stitching, drawing, twitching, itching, burning, smarting in different parts of body, now here, now there. Jan 10th.- 10 gr. of Ix. After 3 h ., griping, especially about navel, with easily repressed urging to stool (lasting 2 h.) ; diarrheic stool after dinner, without colic or tenesmus. During next d., especially in forenoon, frequent reminders of gripings, weakness, nausea ; also fretful disposition and strong aversion to drug. 14th.- 1 gr. of same at 8 a.m. produced more transient griping. After 2 gr., 4 h. later, painful gripings, and long-lasting movements in region of stomach, ending in loose stool. Towards e., pressive pain in several places on thorax, in hepatic region and over heart, impeding respiration (for several h.). 15th .-Long stitches on inner side of 1. thigh, from ischiatic tuberosity towards knee, in forenoon, when walking (frequently repeated for several m.) . Towards noon, griping about umbilicus, and sensitiveness of abdominal integuments aggravated by pressure. 22nd.-10 gr. of 3x, in m., caused movements in abdomen, frequently repeated during d.; on following m. constant violent smarting on middle of tip of tongue, as ifpart was sore ; drawing-stitching pain on outer side ofthigh, while walking. c. In Dec., 1843, W- proved tincture by rubbing it into abdomen. From 10-40 dr. produced very slight symptoms,-transient gripings, several small evacuations in d., with frequent inclination for stool ; clucking in groin. From 50 dr., rubbed in towards midnight, unusually noisy discharge of much flatus in m., movements in bowels, sensitiveness of abdominal integuments, repeated but easily resisted inclination for stool. From 100 dr., sensitiveness about anus, with frequent urging to stool, which was unsatisfying and diarrhæic, but painless; clucking in a spot below navel ; painfulness of abdominal integuments, especially when walking ; griping and frequent micturition with apparently increased flow. On following d. same symptoms followed a similar application ; in e., painfulness of whole head, most felt in frontal region, aggravated by bowing or turning head, with incapacity for intellectual work, lasting some h. ( Ibid.) 17. Dr. WEINKE, æt. 30,strong, ingood health. Nov. 19th, at 9.30 a.m. , 12 dr. of tinct. An h. later, while writing, painful pressure in dorsum of r. foot towards great toe, with slight numbness of r. leg ; less felt on walking, and disappearing in 15 m. At 10.15 took 15 dr. more. Towards 3 p.m., pappy stool, with slight griping and rumbling, and later, transient stitches in l. chest. At 7 p.m., semi-fluid stool, with a perfect storm of flatulence. All p.m. feeling as of having taken cold in bowels, so that diarrhea would follow. 23rd.-20 dr. at 10.30a.m. Abdominal symptoms recurred in h. P.m., lassitude. 30th.-60 dr. at 10.30 a.m. Recurrence of sensations in chest and abdomen shortly afterwards, and at 11.45 of those of foot. At 2, sudden tenesmus, copious pappy stool, same sensations in belly, sleepiness, disinclination to study. At 4, similar stool, followed by flatulence and debility.

For three following weeks heavy sleep, full of dreams ; heaviness of legs ; swelling of both feet ; persistence of pain in r. dorsum (as if in periosteum) ; at r. edge of tarsus a tumour size of pigeon's egg, soft, pale, painless ; same pain in l. foot, but no tumour. While these symptoms lasted, bowels were sluggish, but stools not hard ; constant flatulence ; urine apparently rather diminished. ( Ibid. ) 18. Dr. WÜRSTL, subject to gouty-rheumatic pains, toothache, diarrhea, &c ., proved drug in doses of 1-10 dr. of tinct. He experienced short attacks of these very symptoms, apparently traceable to drug ; but after proving was over found himself perfectly relieved of the pains, &c., which formerly annoyed him so frequently, and stronger and more healthy than ever before. [Under these circumstances, we have deemed it best to omit Würstl's detailed sensations, as of doubtful purity.-EDs .] 19. a. Dr. WURM, æt. 36, strong and healthy. Nov. 8, 9, 10, took 1, 2, 4 dr. of tinct. without result,save that on 11th his usual stool was absent. On 11th took 6 dr. at 10 a.m., whereupon came oppression of head, worst after dinner, nearly disappearing towards e.; frequently recurring tearing in r. metatarsus, near great toe joint, in e. ; frequent micturition . 12th.-8 dr. in m., without effect save a second stool p.m. with slight burning at anus following. 19th and 20th.- 10 and 15 dr., with nothing but quantity of inodorous flatulence. 22nd.- 25 dr. After 5 h. violent urging to evacuate bowels, demanding instant attention ; copious fæcal diarrhea with great discharge of wind. 23rd.-30 dr. in m. Little appetite at dinner, though food tasted well ; pappy taste in mouth for 1 h. thereafter ; pretty violent pressing pain in l. little finger about 6 p.m., particularly towards middle joint, soon disappearing, then same pain in all r. toe-joints, save those ofgreat toe, for 8 m. 24th.-40 dr. in m. Usual effects on bowels p.m. 25th and 26th.- 20 and 30 dr. caused similar symptoms, but colic was more violent and lasted longer. 27th.-40 dr. a.m. Continued perfectly well all d. and had no evacuation ; but slept badly following n., often roused by vivid dreams, every time finding himself in a perspiration. 28th.-50 dr. at 8.30 a.m. Pressing and throbbing in first joint of 1. great toe, as if boot were too tight, going off on moving about ; heaviness of feet, most troublesome in forenoon, as though he had made a long pedestrian journey ; while sitting constant sensation in both feet as ifthey were going to sleep. Itching inducing scratching here and there, especially on scalp. Soft stool after dinner. 29th.-Heaviness in feet felt again on waking, going off on moving about ; hard insufficient stool about 5 p.m. In n. many and vivid dreams, waking him nearly every h., when also he found prepuce retracted and somewhat constricted. Each time he brought it forwards he found it retracted again at his next waking. 30th.-40 dr. at 8.30 a.m. and 20 at 5 p.m. Aching in hypogastrium soon after dinner, ameliorated by discharge of abundant fœtid flatus, and disappearing after stool at 4. Sensation of violent pressure in 1. temple all p.m., better while sitting, worse standing and walking, specially violent after micturition. N. as last. Dec. Ist and 2nd.-Frequently repeated aching in an upper hollow tooth ; drawing in r. ankle ; very transient sensation of pressure in different

parts of body, especially finger- and toe-joints ; insufficient stool. 3rd. -50 dr. a.m. After 6 h. griping in hypogastrium, abundant discharge of flatus. Colic paroxysmal, very violent, obliging him to bend forward, continuing 2 h., and only ceasing after expulsion of soft stool. Very weak in e. before going to sleep, and on waking next m., but better after moving about ; no stool on 4th, frequent micturition ; itching in various spots on body ; feeling of pressure injoints. 5th.- 60 dr. at 8.30 a.m. Oppression ofhead, most felt in r. frontal region, continuing all d. Colic p.m. as on 3rd, also lassitude, itchings, and pressure in joints. In e. while sitting 1. foot feels as if it would go to sleep. 6th.-Save drawing in calf and thigh and absence of evacuation, no symptoms. 7th, 8th, and 9th.-50, 40, and 35 dr. taken in forenoon produced almost identical phenomena-i. e. symptoms of head, abdomen, and bladder as before ; also pressure and weight in sacrum. On 9th, in addition, transitory drawing in various joints of upper and lower extremities, especially fingers and toes, disappearing instantaneously on motion, as rapidly returning in rest. This last symptom troubled him quite often the two following d., when he took no medicine. 12th.-40 dr. Usual abdominal symptoms p.m. 13th .- On getting out of bed, drawing in l. ham, as if tendons were too short ; oppression of head ; pressive drawing in joints of toes and fingers, as well as in r. knee. Joint troubles remained all d., but not long in one place. 14th.-45 dr.a.m. Soft stool and frequent micturition. 15th. -Transient drawings in several joints, and in 1. neck (especially on turning head). These returned for several d. but with less violence and frequency. On 17th, in e., also for several h. violent pressure in sacrum, and l. foot felt as if going to sleep. On 18th, in e., sprained feeling in all toes of 1. foot when going upstairs . b. Provings of triturated pulp.-19th.-12 gr. of Ist cent. Joint pains still perceptible ; nothing else. 20th, 21st.- 24 and 40 gr. No symptoms, save on m. of 22nd burning at orifice of urethra after micturating, for I h. Took 50 gr. that forenoon, and same next m . Oppression ofhead, insufficient stool with burning and stitches at anus, and burning in urethra after micturating. 24th.-20 gr. of a 1-20 trit. After 3 h., cramp at middle of 1. thigh with usual abdominal and joint symptoms. Towards 5 p.m., prostration, with chills, violent thirst, and quickened pulse ; this febrile excitement lasted for h. During it was possessed with idea that he was not in his own room. Well in e. 25th. No stool. Joint pains returned paroxysmally, especially while walking about. At 7 p.m., while walking, cramp-like drawing inner side whole length of r. thigh ; felt very much debilitated, but only when at rest. 27th, 28th.-30 and 40 gr. developed succession of symptoms over 12 d.,-drawing and pressure injoints ; hard insufficient stool ; on Jan. 3rd 3 small boils on neck and larger one at lower angle of l. scapula, with burning pain ; drawing in inner side of 1. thigh. By 8th perfectly well. Took 15 gr. on 15th, 30 gr. on 16th, 18th, and 19th, of I, trit. with usual abdominal symptoms only. c. On each m., from 21st to 26th inclusive, took 10 dr. of 1, dil. of tinct. without effect, save that he was awakened on 23rd at about 4 a.m. by a violent, pressive-throbbing headache in frontal region,

Although pain went off on sitting up and moving head, head remained much oppressed all forenoon. (Ibid.) 20. HECHENBERGER.-A single drop. of tinct., m. and e., seemed to have no effect on ordinary people during 5 or 6 d. On persevering in its use, a copious, strikingly brown, often black, stool occurred, preceded by painless rumbling. If dose were still continued, stools kept growing thinner, but always brown, with lively borborygmus. A drop repeated every 2 h. from early m. brought on, p.m. and e., in persons not altogether torpid, diarrhea, without colic or other inconvenience. From 4 to 8 dr. in single dose in m., occasional slight diarrhea same afternoon, or at least next m., preceded by griping in umbilical region. Further almost constant symptoms of continued use ofC. were : striking increase of appetite and thirst ; more copious secretion of urine, which was often light-brown like beer, becoming cloudy on cooling, and depositing a copious, sometimes sandy sediment ; noisy discharge of a great deal of wind ; gentle, painless awakening of hæmorrhoidal flow, leaving behind peculiar burning around anus and along sacral region ; menses more profuse and too early. (Kolocynthologie, 1840 ; quoted in Ibid. , p. 38.) 21. KRUMBHOLZ, Nov. 26th, 1836, took 3 times during d. several drops of tinct. in water. At n. quiet sleep. 27th.-Took same. In afternoon uneasiness throughout body, especially in digestive organs. Towards e., pains in bowels, with feeling of great heat in stomach ; they increased in severity, till towards 9 p.m. there occurred a troublesome diarrhea for h., after which pains went off. Sleep not very quiet. Dec. 2nd.-Took in m. and p.m. gtt. xv of same. About 2 p.m. same uneasiness, confusion of head, great heat of stomach, violent pain in bowels, loose stool about 3, whereupon pain and uneasiness subsided. On 3rd, took 2 more doses with same results. (Martin's provings, Hom. Viertelj., x, 1.) 22. MARTIN took, Nov. 28th, 2 dr. in water at 10 a.m. In 1 h. pain in l. arm, soon going off. Urging to stool. In e. same dose. Soon after some pain in bowels and in forehead (l. frontal nerve). Urging to stool. At 7 p.m., 3 dr. In 15 m., pains in bowels, with feeling of approaching diarrhea, pulsation in 1. arm. After supper abdomen very full and heavy. Same next m. Urine scanty. At 10 a.m., 3 dr. Violent itching at anus. Dec. 3rd. At 5.30 p.m., 6 dr. Collection of saliva in mouth. In h. contractive pain in r. hand, which constantly increased, until similar pain occurred in 1. malar bone ; as this abated hand-pain extended into forearm, but declined as pain came on in r. cheek and (later) bowels. Itching in face with painful drawing, which latter after a time came also in l. forearm, persisting at elbow. A similar pain later outside of r. thigh, during which there was toothache in l. upper molars. In 1 h. heartburn, following voracious hunger ; then very crampy pain in l. forearm. About 10 p.m., during walk after supper, transient, pressive, contractive pain in scrob. cordis. On followingd. itching at anus . 6th. At 10 a.m., 10 dr. Oppression in forehead, sore feeling at scrob. cordis, pressive pain in l. cheek. After h., violent headache, going off in h. Later, unusual weariness, weight of head, itching at anus, strange burning in pin-scratches

COLOCYNTHIS . 361 on fingers, also on face and head. 7th.-In m. occasional violent pains in l. forearm. (Ibid.) 23. MAYER, Nov. 26th, e., took 2 dr. of tinct., and noticed next m. slight pain in stomach with headache, and also moderate diarrhea. 28th.-Took 2 or 3 dr., and had violent stomach-ache, with flatulence and headache, but without diarrhea. Became also lazy, gloomy, and listless, almost without spirit. In consequence, he took smaller doses only ( I dr.) . Symptoms lasted some time longer, but finally nothing save flatulence remained-till 30th. Dec. 1st.-Again took 3 dr., whereupon previous symptoms immediately recurred. Felt specially pressive headache on small spot at about middle of linea semicircularis ; also alternate heat and cold, or transient and recurring perspiration, without change in temperature ; there even occurred some threatening of syncope, but this he was able to ward off by holding hand before eyes. These symptoms seemed more severe in e. than in m.; next d. they were much less felt, but teeth seemed on edge, as they had begun to do on previous e. All went off gradually, as it came on ; stomachache and depression of spirits lasted longest. (Ibid.) 24. RUNGE.-Nov. 26th.-From 6.30 a.m. to midnight took repeated doses of 2-5 dr. of tinct. P.m., had urging to micturate and collection of saliva in mouth. Towards e., great lassitude ; peculiar state of mind, cannot pursue any train of thought. Repeated doses on 27th, without effect. 29th.-From 3.30 to 10.30 p.m., 4 doses of 6-10 dr. After each, rumbling in stomach ; towards 8, oppression about heart. Wakeful n., but felt well next m., save for transient pressure in scrob. and abdomen. 30th. At 6.30 a.m., 10 dr. Soon after liquid stool. At 9 a.m., 12, at 11.30, 20 dr. After dinner stupefied feeling in head; stomach-ache ; for a few moments almost giddy; transient deafness-at least he heard everything accompanied by a roaring noise, nothing seeming to him to have its proper sound. All this lasted but a few m. At 3.30, 10 dr. Towards e., internal oppressed feeling, accumulation of saliva. At n. again great wakefulness ; quite liquid evacuation 3 times in e. and once next m. Dec. Ist. -Disagreeable feeling in all limbs on making mental exertion. P.m. , great lassitude. At 7.30, 12, at 11, 20 dr. 2nd.-At 9 a.m. , 20 dr. Very liquid evacuation. Oppression and stitch on breathing in r. side, not very considerable. At 12.30, and at 2, 36 dr. 3rd.-At 8 a.m., 30 dr. Soon after liquid stool. Weakness, fulness, prostration all d.; and another watery stool. At 11 , 36 dr., without any fresh effects . (Ibid.) 25. Dr. J. V. MÜLLER took at 9 a.m. 20 dr. of4th dil. No effect till 5 p.m. , thereafter on walking briskly some painful obtuse stitches, suddenly coming and as suddenly ceasing, in r. hip, that caused him to stop his walk for a short time. This recurred so often that he had to give up his walk and go home. Amelioration when sitting, but instead ofthe above pain he felt a heavy weight in the lumbo-dorsal region, which was only relieved somewhat by lying on 1. side. The painful parts felt warm and sensitive to touch. On rising and walking the stitches above mentioned recurred, but the dull weight went off. At n. in the warm bed the pain declined, but it woke him about 4 a.m.

It was now throbbing, almost boring in character. The point of origin of the pain was in the sacral region at the seat of the plexus ischiadicus, it passed thence through the incisura ischiadica major towards the hipjoint, whence the pain radiated to the posterior aspect of the thigh and towards the knee-joint and popliteal fossa. In its origin and course it corresponded to the seat of the sciatic nerve. But it also spread to the branches ofthis nerve to the glutæus superior and inferior. The feeling was as if the hip-joint were fastened by clamps to the pelvis. Other symptoms were : slight febrile movements with development of heat, tendency to sweat, and moderate thirst. The following m., after the pain had lasted 17 h. (it did not quite go offtill after 30 h.), the urine was examined ; it was clear, scanty, dark orange coloured, sp. gr. 1030, acid, urophain and uric acid increased, chlorides diminished, increased discharge of epithelium. (Z. d. V. d. Hom. Aerzte Oesterreichs, 1857, i, 43.) 26. Dr. LEMBKE took , Feb. 21st, 7 a.m., 5 and 8 p.m., 5 dr. tinct. At 5 p.m. , pressure and drawing in r. temple, several times repeated, tearing in forehead. 6 p.m., boring in r. knee, several times repeated.- 22nd, 8 a.m., 5 dr. 5 p.m., 10 dr. Tearing and pressure in r. temple, stool confined. -23rd, 7 a.m. , 10 dr. At 8 a.m., a soft, dark brown stool. 10 a.m., severe boring in r. lower jaw. 2 p.m. , soft, dark stool. E., tearing in forehead.-24th, 8 a.m., 10 dr. Soft stool, boring in r. temple. 2p.m., boring inl. temple, frequently repeated. 3 p.m., liquid, bright yellow stool. 6 p.m., liquid, dark green stool.-25th, 8 a.m., 10 dr. Much rumbling in bowels, tearing in both temples frequently repeated. E., a soft yellow stool, tickling in larynx, dry short cough, especially at n., which wakes him.-26th. Atnoon ahard dark stool. Much flatulence in bowels and discharge of flatus.- 27th, 8 a.m., 10 dr. Last n. frequent dry short cough. Tickling and irritation to cough in larynx. 9 a.m., yellow, small, firm stool. Much flatus discharged. Frequent short cough without expectoration. At noon, copious, soft, bright yellow stool, with great development of flatulence. 2 p.m., a liquid, bright yellow stool, preceded by much tumbling in bowels ; several times pain in umbilical region, tearing in r. temple. 8 p.m., liquid bright stool, preceded and attended by much pain in belly.-28th. At noon, a liquid, bright yellow stool. During all these d., but more and more frequently at n., short dry cough that wakes him, and is accompanied by much scraping and tickling in larynx.-March 1st, 8 a.m., 5 dr. At noon,bright yellow soft stool, tearing in r. temple repeatedly, drawing in r. leg when sitting. 5 p.m., 5dr. Drawing and pressure in knees when sitting, with exhaustion and bruised feeling ; pressure and drawing in r. ankle-joint, boring in r. hip-joint; bruised pain in sacrum and in both inferior extremities ; short dry cough at n.-2nd, m., pain in knees and hips as if bruised and tired, severe pressure in 1. ankle-joint. 8 a.m., 5 dr. Drawing in r. toes, pressure in r. fingers; boring in r. shoulder, then inl. knee, later in r. knee. 9 a.m., small, hard, dark stool. Much pressure in knees when sitting; pressure in ankle-joints, boring in shoulders, and in flesh of thighs; tearing in 1. side of head; wandering pains injoints of toes, fingers, and ankles ; shooting in calves, boring in skin of calves, mostly in r. Much pain as if tired in knees, worst when sitting; boring in r. side of occiput; much drawing and pressive pain in joints of hands, fingers, and shoulders; tearing in forehead and cheeks. All d. tearing in joints of arms and legs, worst when at rest. Also during d. sometimes scraping in larynx and short dry cough. At n. dry short cough, and tickling in larynx.-3rd. After rising m. pressure in wrist- and ankle-joints ; a hard, dark green stool. 8 a.m., 5dr. Pressive pains in wrists, drawing and pressure in knees and tibiæ; tearing in 1. side of forehead ; tired pains in knees when sitting ; boring in r. toes ; boring pain in r. lower jaw ; drawing above r. ear and in r. ankle-joint; tearing inl. upper arm ; pressure in elbow-joints, in flesh of thighs frequently. Much flatulence in bowels ; tearing on instep frequently; all these pains frequently recurring during d., more severe when at rest than when moving. By d. dry tickling cough with nausea ; retching, almost vomiting ; the cough comes on suddenly without cause. E., a firm dark stool; severe boring as with a peg in 1. temple, in e frequently; boring in

COLOCYNTHIS. 363 elbows and shoulders. 9 p.m., pressive and boring pains injoints of toes and fingers ; drawing in hands and fingers in various places, then in foot and ankle ; tearing in forehead in different spots. 10 p.m., drawing in face and toes. Much tickling cough e. and n.-4th, m., tearing in cheeks, on different parts of forehead; frequent drawing in tibiæ, hands, and fingers. 8 a.m., 5 dr. Drawing and boring in shoulders and wrists; drawing in forehead ; pressure in joints of upper arms ; boring in temples. All these pains are of frequent occurrence,jump from one part to another, but remain nowhere long ; tearing in r. side of skull ; the pains are worst when at rest ; a hard dark stool ; bellyache about navel. As the pains in limbs increase the cough declines. Tickling cough at n.-5th. The same pains in the limbs as on previous days; tearing inhead and l. side offorehead ; drawing in flesh of thighs when sitting; boring in joints of toes, then in shoulders, then drawing in various parts of head; when walking boring and drawing in head, joints of fingers, shoulders, knees, tibiæ and ankles ; a hard dark stool. In e., pains in limbs increased when sitting ; they are particularly severe in knees, feet and shoulder-joints; their character is pressive, drawing and tiredpain. Tickling cough at n.-6th, m., same symptoms in limbs as last e., alsoboring in bones of head, especially on r. side, repeatedly ; they are always worst when at rest, not so bad at n. 8 a.m. , 5 dr. Much boring in forehead and cranial bones; a hard dark stool; much aching in knees and anklejoints; drawing pains in knees; severe and frequent aching in wrists ; tearing and burning pains in r. elbow; burning and drawing in thigh-muscles; much boring and tearing in forehead, during d. and in e.; burning and aching pains in muscles of r. thigh when walking, making walking difficult and tiresome. E., soft dark stool ; much tickling cough at n.-7th. After rising, m., drawing, aching, boring in wrists, fingers, knees, thigh-muscles. During d. same pains againasinon e.; 6th, sameespecially pains in boring e. Atinforehead and temples. n. ticklingcough. Adarkhard -8th. After stool, and rising, rawing agaiankle-joints, shoulders, inlegs, forehead, muscles of thighs, wrists, knees, quickly changing locality. A small painful pile. 8 a.m., 5 dr. Much aching in knees and wrists when sitting, then in muscles of thighs ; much boring, aching, pinching in calf-muscles ; frequent boring in r. side of forehead ; drawing aching in wrists when sitting ; a hard dark stool ; the hard stool consisted of small lumpy fæces. Aching and drawing in forearms ; when walking drawing in legs and knees ; bruised pain; also when sitting. Boring aching in ankle-joints when walking; these pains are not worse whenwalking, but retching almost to vomiting are as bad when sitting. Much tickling cough with retching several times during d. Tearing and boring in forehead when walking. 2 p.m., light-coloured soft stool, partly in lumps. Urine darker than usual. 4p.m., 5 dr. All d. drawing and aching in same joints and parts of body, more when sitting than whenwalking. Much tickling cough e. and n At n. much flatulence in bowels.- 9th, 6 a.m., a light-coloured soft stool. Besides above pains in limbs, much bruised pain in knees, arms, shoulder-joints, when sitting, tearing in r. side of forehead. Drawing and burning in muscles of 1. axilla towards arm, later some pain in r. shoulder ; much boring in ankle-joints ; drawing shooting in flesh of thighs ; when walking drawing in muscles of calves and thighs, making bending legs difficult and painful; this frequently occurs when walking and hinders walking;; much aching and boring in wrists and muscles of forearms ; weary pain in arms. When sitting drawing in both groins, frequently repeated, and extending to pelvis. Severe and frequent tearing in r. side of forehead, in and above r. temple. Very frequent dry cough, with tickling in larynx, and inclination to vomit; much aching andboring in knees when sitting; drawing in soles ; weight and pressure in forehead towards e. In e. a small, hard, lumpy stool ; some boring above nose and in wrists. All d. these pains recur, are generally felt when sitting, but some only come on when walking, e.g. the painful drawing in muscles of calves and thighs. At n. tickling cough.- 10th, m. , some of the above pains ; a hard dark stool. During d. the same symptoms. For some d. past on skin of 1. upper arm a small pustule without pain; to-day it is surrounded with a hard red areola, and is the seat of burning pain, worst when moving arm. Severe boring and burning pain in r. side of forehead. At n. much tickling cough.- 11th. Same symptoms. The swelling on upper arm is harder, larger, redder, and more painful, drawing all through arms. 8 a.m., 5 dr. Ahard lumpy stool, much flatulence. Noon, a soft dark stool. Tearing, drawing, aching in various joints and parts of head as before, especially much boring in r. side

of head and behind r. ear ; frequent pressure in stomach and umbilical region ; much tiredpain injoints. At n. much tickling cough.- 12th, m., a dark, small, lumpy stool. Boring and drawing in knees, r. side of head, and forehead. Bruised pain in all limbs ; boring and drawing in ankles and instep, when walking, repeatedly ; frequent boring in toe-joints. The swelling on l. upper arm is harder, larger, more painful; the pains in it extend sometimes to axilla and fingers. Drawing in tibiæ, worse on 1. side, in calves, worse when sitting. Frequent boring in malleoli of ankles and in forehead, when sitting, e. A soft, dark green stool in e. At n. sleep greatly disturbedbypain in pustule.- 13th. The swelling is one inch in diameter, is deep, is pointed, bluish red, hard, hot, painful; the glands of 1. axilla swollen, painful ; painextends to elbow, sometimes into fingers, all the 1. arm is more painful when moved. Drawing aching in forehead, in muscles of thighs, in knees,when sitting. Aching inwrists; drawing in toes, extending to insteps and ankles. M., a small, lumpy, dark green stool, much flatus. Boring in r. side of forehead. 8 a.m., 5 dr. Bruised pain in knees when sitting; drawing behind 1. ear. Aching in knees repeatedly when sitting ; drawing in legs and ankles, aching in calves, when sitting. Aching in shoulders ; boring in various parts of head on r. side, then in 1. side of forehead, repeatedly. Pressing drawing in calves when standing. Aching above knees when walking, frequently. Also when walking drawing in tibiæ, ankles, calves, toes, arms, wrists, hands. During d. frequent tickling cough with nausea, inclination to vomit, retching. Great boring in forehead, especially r. side. E. , very violent pressive pain in r. knee, repeatedly, when standing. Boring in r. maxillary joint. Compression in r. leg when sitting. 7 p.m., pressing in wrists and finger-joints. Drawing and pressing in calves when sitting, then aching in tibiæ and knees. The pains jump from one part to another and change their character quickly; they are alternately drawing, aching, boring, pressing. Drawing in nape, then on both sides of tendines Achillis, when sitting. N., much tickling cough.- 14th. After waking, in bed, some of the former pains in lower extremities, and after rising aching and boring in forehead. 8 a.m., repeated drawing on sides of tendo Achillis when sitting ; boring in r. temple ; during d. some boring and aching in forehead over eyes ; then repeated drawing behind r. ear; pressing in l. leg when walking, in fingers and 1. hand. Tickling cough also at n. The boil on 1. upper arm larger, harder, more pointed, exudes pus ; glands of 1. axilla swollen, painful ; drawing pain in whole arm.- 15th, m., boring in forehead; pressing in thighs repeated aching and drawing in thigh-muscles uscles withtired pain; drawing inankles when sitting, also in fingers and wrists; boring and tearing behind 1. ear. 8 a.m. , 5dr. Frequent drawing in lower part of thighs when sitting. The boring and tearing in forehead above eyes repeatedly during d. Severe and frequent boring in several parts of muscles of 1. thigh when sitting. A dark soft stool. Pains more frequent and severe when sitting than when walking ; muchtickling cough. 5 p.m. , severe boring in joints of r. big toe. Shooting and boring in tips of r. toes. Tickling cough at n.- 16th. Same pains as yesterday; a dark soft stool. 8 a.m., 5 dr. Same symptoms as yesterday, especially pressing in toes and wrists and boring in forehead. Pains change their seat frequently and quickly. Boring above and behind r. ear ; tearing and boring in forehead; tickling cough also at n.- 17th, m. , in bed, tearing in toes, knees, ankles, hands ; tickling cough. After rising same symptoms, but more frequent and severe, especially aching and drawing in joints and muscles of lower extremities, with tired pain in knees and legs ; boring on instep and bend of foot. 8 a.m., 10 dr. Much boring in head in various parts. The swelling on l. upper arm discharges pus ; the hardness, redness, and pain are less, the swelling of axillary glands gone down. Much drawing in r. hand and wrist, then in r. elbow and forearm. Severe and frequent aching and drawing in muscles of r. thigh. Same symptoms as previous d. Twodark soft stools. All the pains seem to be increased ; those inmuscles of limb and seat are more boring and burning.-18th, m. , repeated drawing on both sides of tendo Achillis ; much aching and tearing in muscles of thighs and forearms ; boring in wrists, forehead, r. side of head, knees, ankles and above them, when sitting. 8 a.m., 10 dr. Besides above symptoms shooting in tip of tongue. The pain in some joints is sometimes as if encircled with a tight ring. All pains worst when seated. Shooting in some finger-joints, in skin of calves, in muscles above knee. Severe boring in forehead. Drawing in l. toes and shooting in their tips. Very painful boring in l. knee, also when standing and walking. Draw.

ing and aching in fingers and hands, as if squeezed together, then the same in 1. knee. The abscess on 1. upper arm still discharges pus, but is smaller and less painful. When walking boring in dorsum of foot, in ball of big toe, in tendo Achillis. Frequent tearing and aching in various parts of occiput, in 1. zygoma. Drawing in muscles of nape. Aching in scapulæ; two soft stools. During d. same symptoms as on previous d. After pain in limbs and joints they feel as if bruised from overexertion. Pains all worst when sitting, but they sometimes come on when walking. Frequent pricking as from needles on the tips and under nails of 1. toes. 11 p.m., a soft stool mixed with hard lumps. E. and n., much yellow urine, and tickling cough.-19th, m., same symptoms as yesterday. Bruised pain generally and fatigue when walking, which go off on continuing to walk. Frequent tearing on sides of tendo Achillis, sometimes very severe aching pains in thigh muscles when sitting. Boring in toe-joints when sitting. Frequent and severe boring in joints of lower extremities, worse in e. when sitting. Aching, drawing, boring in nape muscles , in various parts of occiput, in r. side of head, worse in e. Two loose stools with much flatus. 8 p.m., 10 dr. Same symptoms occur. At n. only tickling cough.-20th. Pains like previous d., also boring and drawing in r. shoulder and temple,drawing in r. side of forehead, burning in 1. sole. Two soft dark stools. Tickling cough at n. -21st, m., same symptoms. 8 a.m., 10 dr. Much boring in knees, forehead, r. side of head, ankle-joints, toes and feet, worse when sitting. Drawing in several fingers, in thumb-ball, lower jaw, 1. elbow. 9 a.m., tired pain from knees to leg and ankles when sitting, repeatedly. Abscess in l. upper arm healing, still discharges. Violent boring in various parts of muscles of thighs and forearms. The former pains also recur with tired or bruised feeling. Frequent boring behind r. ear and in forehead. At n. much tickling cough.- 22nd, m., same symptoms. D. and n. much tickling cough.-23rd, m., pains as before. 8 a.m., 10 dr. Much drawing in fingers, hands, wrists. Aching in knees; boring behind r. ear; drawing in legs and arms . Two dark soft stools. Dry tickling cough d. and n.; boring in forehead and r. temple.-24th. Same symptoms all d.- 25th. Same symptoms. Two soft dark stools.-26th . Same symptoms ; they are worst m. and e. The tickling cough is sometimes worse at n. than at other times. The boring, aching, drawing pains are sometimes very severe in forehead, face, ankles, and wrists, in one side of head, in knees, occiput, and toe-joints. In the following d. the pains gradually abated, and the tickling cough disappeared. The 2 soft dark stools daily continued for a considerable time. None of the symptoms except the tickling cough occurred at n. Aggravations occurred m. and e. and when at rest. (N. Zeitsch.f. hom. Klinik, xv, 49, 65.)

1. a. Böcler says that those who handle C. for a long time become affected with vomiting ; and Sachse saw this result induced by laying it upon stomach. b. Michaelis states that extr., laid upon bare skin of epigastrium, produced diarrhea. Chrestien noticed frequently increased evacuation of fæces and urine from external abdominal application ; and Neumann saw from friction with tincture and castor oil ( 1-4) violent colic and frothy diarrhea with blood. ( Oest. Zeitschr. , i.) II. Poisonings.-1 . A woman of 40 was advised, for rheumatic pains in shoulder and thigh, to boil lb. of colocynth in red wine, and drink the strained liquor before going to bed. Fortunately she divided the potion into two parts, for she had hardly swallowed the first half before she was seized with frightful pains in region of stomach, great anguish, vertigo, fainting fits, and spasms. Frequent vomiting set in, but without relief ; then stools, first fluid and feculent, later almost of pure blood, with frightful tenesmus, and passage of pieces of intestinal mucous membrane 2-3 in. square. Pain then became concentrated in stomach and lower end of rectum ; abdomen was collapsed ; finally tenesmus ceased, and she gradually fell asleep. Oily and mucilaginous

drinks, with opium,were administered, and patient gradually recovered, but was compelled to keep her bed a long time from weakness and dyspepsia. (SCHEEL, cited in Oest. Zeitschr., i.) 2. A man of 55 took for a swelling of knee a small quantity of tinct. He was shortly afterwards seized with nausea and vomiting, with feeling of heat and burning in epigastrium. Delighted with this result, he took a second and third dose to increase the effect. Copious, exceedingly frequent stools now came on, and such intolerable pain in whole extent of abdomen, and so violent a colic, that he sprang out of bed and rolled on the floor. Convulsions of the strongest kind soon set in, and patient died ere n. P.M.-Stomach and duodenum externally purple, jejunum and ileum rose coloured ; mucous membrane of former parts was vividly reddened, full of erosions, loosened, and very easily detached. Similar abnormal appearances were found in lower portion of small intestine, but less decided ; and large intestine was but little coloured externally or internally. Whole canal was empty. (DUVERGIE and RATIER, in Ibid.) 3. A pregnant woman, who took a teaspoonful of tinct., was seized with a dysenteric flux, burning pain in loins, swelling of vulva, and sense of bearing down and heat in vagina. (HECHENBERGER, op. cit.) 4. A man, æt. 28, who suffered from bleeding piles and dyspeptic troubles, drank two glasses of a decoction, and experienced colic, frequent stools, and some h. later-great heat in bowels, dryness of pharynx and unquenchable thirst. Dr. Carron found patient with small accelerated pulse,tongue red, abdomen tense and very sensitive to touch, umbilical region verypainful, bowels constipated. In spite of soothing measures, abdomen was on succeeding d. still more painful and tympanitic. In e. there was retention of urine, retraction of testicles, and priapism . On 3rd d. (after nitre) retention of urine relieved, but other symptoms continued ; pulse was small and contracted, and hiccup, coldness of extremities, and clammy sweat on head and chest came on. In e. pains ceased ; abdomen sank in, and there was manifest fluctuation. Patient died in n. P.M.-Intestines red, with black spots ; for most part glued together with lymph ; a whitish fluid had been effused into abdomen, filled with a quantity of white flocks ; ulceration here and there in mucous coat of stomach ; traces of inflammation in liver, kidneys, and bladder. (ORFILA, Toxic. , sub voce.) III. Experiments on animals.-1 . The esophagus of a mediumsized dog was tied, after 12 grm. of powder had been administered. He soon after made violent efforts to vomit ; in II h. his gait became unsteady, and he fell as ifgiddy. Two h. later he gave hardly any sign of life, and allowed himself to be shoved about like a lifeless mass . Death occurred 13 h. after administration. P.M.-Mucous membrane of stomach at cardiac end dark red, with blackish streaks, rest to beginning of colon bright red; large intestines little changed, save rectum, whose lining was highly inflamed and fiery red ; lungs and cerebral vessels filled with blood. (ORFILA, op. cit.) 2. An infusion of zij in wine was introduced into stomach of similar dog, and œsophagus tied. He whined during d., became weak, had 2 copious stools, and died in 22 h. Mucous membrane ofstomach,

duodenum and jejunum reddened throughout, with dark-red spots at places ; ileum, cæcum, and commencement of colon almost normal ; in lower colon, and in rectum, blackish raised streaks on fiery red ground. ( Ibid.) 3. A wound was made in thigh of a dog, zij of finely powdered C. inserted, and the lips brought together. The animal did not seem troubled the d. after, did not whine, and went about as usual ; but he died during following n. Mucous membrane of rectum was very much altered ; nearly whole surface was covered with blood-red spots ; rest of canal unaltered. (Ibid. ) 4. A strong white rabbit, 10 weeks old, was poisoned gradually during 7 d. with 10-30 dr. doses of tinct. No symptoms save increasing dulness and weakness. P.M., 20 h. after death .- Animal emaciated ; skin easily separated, and on hind legs tender, and coming off only piecemeal ; areolar tissue of latter infiltrated with a gelatinous mass. Muscles pale and flaccid. Mucous coat of stomach pale, with dendritic injection of vessels, easily torn ; mesenteric vessels injected with bright red blood throughout whole course of intestine. Liver much enlarged ; upper surface marbled with dark- and pale-red ; section there presenting granulated appearance throughout, in other places only in spots ; whole five lobes exhibiting cavities of size of millet seeds, filled with a purulent-looking fluid ; gall-bladder distended with similar fluid. ( Oest . Zeitschr., i .) 5. Another rabbit had taken daily for 8 d. 5 gr. ofthe I, trit. without manifesting any particular symptoms. He then took at 8 a.m. 40 dr. of tinct. He became weak h. after dose, and remained motionless,with eyes fixed and staring alld. Some diarrhea occurred at noon, and he died at 7 p.m. P.M. , 12 h. after death.-Emaciation ; veins ofthighs and cerebral vessels filled with dark blood, r. heart the same, 1. empty. Stomach marked with a few bright red injected vessels ; general mucous coat pale, easily torn. Adhesions in places between large and small intestines ; whole mass, as well as entire mesentery, marked with bright red injected vessels, which surrounded bowel, and towards lower portion by one straight vessel ; inner surfaces red only at extremity. Liver of normal size, colour, and consistence ; scantily set with whitish, millet-seed points, permitting purulent moisture to escape on being opened ; gall-bladder distended with thin brownish bile. (Ibid.) 6. Röhrig [as also Rutherford, EDs.] from his experiments on fasting animals, is led to place C. high among cholagogues. It makes the bile watery, but also increases the solid constituents. It powerfully stimulates the intestinal glands. (RINGER, op. cit.)