Colchicum
By Timothy F. Allen — The Encyclopedia of Pure Materia Medica
Colchicum autumnale, Linn.
Natural Order , Liliaceæ.
Common name (German), Zeitlose.
Preparation , Tincture of bulb dug in spring (Stapf's provings). [According to analyses the bulbs are most active in the fall just after flowering, Schroff, Œst. Zeit. f. p. Heilk., 1856. T. F. A.]
Authorities. ( 1 to 46 , from Reil's treatise and collection, Hom. Vjschfts., 8, 113).
1 , Stoerck held the fresh root against the tongue for two minutes; 2 , same, took 3 grains of root with wine; 3 , same, took 1 grain of fresh root in bread; 4 , Lewins, Edinb. Med. Journ., 1837, a student took tincture, 20 to 60 drops; 5 , same, a student, 30 to 70 drops of wine; 6 , another person, aged 15, took 30 to 40 drops; 7 , another person, aged 17, took 30 to 70 drops; 8 , another, aged 12, took 30 drops of wine, morning and evening; 9 , another, aged 10, took 15 to 25 drops; 10 , Boecker, Beiträge, took 15 to 45 drops; 11 , other provers took 20 to 45 drops; 12 , Schroff, general summary of provings; 13 , Sonnenberg, provings with tincture, from Boecker's Beiträge; 14 , Krahmer, results of five observations (proving of tincture), Boecker's Beiträge; 15 , Bennewitz, a man, aged 60, effect of 50 drops within an hour, in one subject to gout; 16 , a man, aged 40, suffering from chronic rheumatism, took half an ounce of wine; 17 , Andreæ, 1834, a man, aged 30, took tincture of seeds; 18 , Newbrandt, a man, aged 52, took 6 ounces of an infusion of seeds; 19 , Santlus, poisoning of child of 4 years by seeds; 20 , Shilling, a boy, aged 6, ate portions of the plant; , a man, aged 56, took 1 1/2 ounces of wine, Edin. Med. and S. J., 14; , Boecker, effects on urine; , Krahmer, Heller's Archiv., 1847; , experiments by Chelius; , Dr. Lindemann, seven provings with 3d to 15th dils.; , same man, second series of provings, 3d dil.; , same, provings with 2 to 10 drops of tincture; , W. S., proving with 3d and 15th dils.; , same, took tincture; , C. Sch., a girl, aged 30, took 15th dil.; , same, took tincture; , G. Schladt, proving with 3d and 16th dils.; , same, proving with tincture, 2 to 10 drops; , Dr. Link, took tincture, 4 to 20 drops; , same; , Louisa Link, aged 35, took 5 drops of tincture; , Dr. Schlosser, aged 30, provings with tincture; , same, took 3d and 15th dils.; , Dr. Keil, provings with tincture; , Dr. Rückert, aged 59, proving with 1/10th; , E. R., girl, aged 20 (suffering from chronic inflammation of conjunctiva), took the 1/10th; , Dr. Zeichmann, aged 36, took 15th dil.; , same, took tincture; , Dr. Burkner, took tincture; , Dr. Fegerl, took the dilutions; , Dr. Bohler, took 3d dil.; , Dr. Weber, Deutsch St. Arzk., 1864, a man took an infusion of seeds; , another man took the same; , a young man took the same; , a girl, aged 24, took the same; , Bethmann, Stapf's provings, Archiv. f. Hom., 6, 147; , v. Gersdorf, ibid.; , Hahnemann, ibid.; , Schweikert, ibid.; , Stapf, ibid.; , Marges, Journ. d. Med., 23, from Stapf; , Ehrmann, Diss. de Colch., ibid.; , Boerhaave, ibid.; , Peyer, Peonis et Pythag. exercit., 50, ibid.; , Hopf, Comment. Zom., 6 (1800), ibid.; , Actuarius, Method. Med., lib. 3, ibid.; , Nationalzeit, 1810, ibid.; , De Berge, Journ. d. Med., 22, ibid.; , Collin, Ann. Med., P. II, ibid.; , effects of bruising seeds in preparing tincture, from Unsin's collection of cases, A. H. Z., 52, 42; , Dierbach, two children poisoned by seeds, from ibid.; , Ferreday, Lond. Med. and Phys. J., 1832, a man took two ounces of seeds, from ibid.; , Amer. Med. Lib. and Intell., 1839, some soldiers drank some wine of Colchicum, ibid.; , Hufeland's Journ., 1841, effects of a drachm of wine taken daily, ibid.; , Siebert, Trans. of Nat. Hist. Soc. of Brunswick, 1842, general effects, ibid.; , Maclagan, Mon. Journ., 1851, a young man, aged 26, took 20 drops of tincture, ibid.; , same, another man, aged 25, took 10 drops of tincture, afterwards 24 and 30 drops, ibid.; , same, a healthy girl took 5 drops of tincture, ibid.; , the same, B. proved repeated doses of 1 to 5 drops, ibid.; , Ollivier, Archiv. Gén. de Méd., 1836, a girl, 20 years old, took 4 to 5 ounces of tincture; , Forget, Hygeia, 15, 87, a man, aged 60, took tincture in doses of 1 drachm to 1/2 ounce daily, for articular rheumatism; , Roux, l'Union Méd., 1855, five persons, after operations, were given 60 drachms of tincture by mistake for China; , Dr. Freree, Journ. Hebdom., 1835, a girl, 25 years old, took 5 ounces; , Chevallier, J. de Chim. Méd., poisoning; , Goullon, poisoning (by tincture taken for schnapps); , Sir Ev. Home, experiment on self with the wine (Phil. Trans., 1816 and 1817); , Dayton, poisoning by about 2 ounces of wine, Am. Med. Times., 5, 337; , Henderson, poisoning of a woman by nearly 1 ounce of tincture, Lond. Med. Gaz., 24, 763; , Warncke, a boy, aged 14, drank a wine glass and a half of wine of Colch., Hosp. Tidende, 1863; , Balluf, Diss. de Colch., 1845, poisoning of a boy, aged 2 1/2, by the seeds.
MIND
- Emotional.
- Delirium (second evening), 21.
- Delirium at night, 76.
- Carphologia, 20.
- Lively mood (alternate action), (third day), 37.
- Especially lively mood (second day), 27.
- Sad mood (third day), 37.
- Anxiety, 17, 65, 77.
- Anxiety, causing sighing, 27.
- Irritable and peevish (second day), 32. [10.]
- Very ill-humored; irritable mood (fourth day), 44.
- Out of humor; apprehensive of impending evil, 33.
- Fretful mood, 11.
- Very fretful, 10.
- Great peevishness (second day), 32.
- Morose, ill-humored, nothing is right, 51.
- External impressions, for example, bright light, strong odors, contact, the misdeeds of others, make him quite beside himself, 51.*
- Intellectual.
- Great flow of thoughts at night, which disturb sleep (second night), 25.
- Intellectual faculties very much weakened, 15.
- The consciousness of logical connection was entirely destroyed, and his perceptive faculties were impaired by the slightest circumstances which interrupted the sequence of ideas, 15. [20.]
- Was unable to write connectedly, 15.
- Inability to fix the thoughts, wherewith the forehead seems tense, 27.
- Weakness of memory; he forgets the words which he is about to speak, and can with difficulty collect his thoughts and continue to speak (thirteenth and fifteenth days), 51.
- Very forgetful and absentminded, 51.
- Loss of consciousness, 20.
- Loss of consciousness and of pulse (second day), 20.
HEAD
- Confusion and Vertigo.
- Confusion of the head, 12 ; (second morning), 30 ; (second day), 32, 34, 77.
- Confusion of the head, posteriorly and superiorly, 34.
- Confusion of the head, with slight vertigo, 71. [30.]
- Confusion of the head, with headache, 55.
- Confusion in the forehead (first day), 25.
- Confusion of the forehead, worse on walking in the wind, better in the room, 27.
- Some confusion of the forehead (after one hour), 27 ; (third day), 26.
- Somewhat confused in the head, in the morning, 39.
- Vertigo, even to falling, while sitting after walking (soon), 32.
- Slight vertigo, on rising (second day), 32.
- Momentary slight vertigo, 33.
- Sensation of vertigo and dizziness in the head (soon after), 36.
- Dizziness of the head, with confusion in the middle of the forehead, 27.
- General Head. [40.]
- Perceptible pulsation in the head (after one hour), 39.
- Head falls backwards, 20.
- Congestion of the head, without headache, 39.
- The head seems thick, 27.
- Great pain in the head, 3.
- Headache, 7 ; (soon), 20, 66, 84.*
- Headache deep in the head, extending across through the head between the ears and somewhat posteriorly, not very violent, 35.
- Headache, coming on in the evening, very violent, and lasting through the night (fifth day), 36.
- Transient headache (fourth day), 10.
- Transient headache in the evening, 13. [50.]
- Feeling as if something tightly bound the head (third day), .
EYE
- Objective.
- Eyes wide open, staring, like one intoxicated, 85.
- Eyes surrounded by dark rings, (84); (after eighteen hours), 17.
- Eyes surrounded by deep dark rings, 65.
- Convulsive rolling of the eyes (after four weeks), 20.
- Distortion of the eyes, 85.
- Subjective.
- Dryness of the eyes, 74.
- Heaviness in the eyes, as though he had not slept enough, with injected vessels, 39. [110.]
- Aching in the eyes, 52.
- Pressive pain in the right eye, 52.
- Short, violent sharp tearing in and around the right eye, 52.
- Biting in the right eye, especially in the external canthus, with some lachrymation and feeling as if the lids were agglutinated, 52.
- Brow.
- Pain in the bone over the left eye, on every motion; in the afternoon and evening, it increased to such a severe ache above the left eye, that every slight noise seemed intolerable; the pains remained constant at the same place (soon after taking), next day, the headache returned to the same place; aggravated by every motion of the head; on the third day, the same pain, but instead of over the left eye, it was in the right side of the occiput; aggravated by bending the head backward, or raising the eyes; next day, very severe headache, commencing at 6 P.M., above the left eye, and extending over the whole left side of the head, disappearing after supper (fourth day); on the next day, she awoke without headache, returned in a short time in the left side of the occiput, and extended to the left eye, and even into the face, 36.
- Constrictive sensation above the eyes (second day), 44.
- Slight momentary pressure in the eyebrows, 27.
- Deeply piercing sticking in the upper part of the left eyebrow, with a feeling as though it were drawn upward, 73.
- Fine stitches above the right eye (second day), 33.
- Lid.
- Ulceration of the Meibomian glands of the left lower lid, with swelling of the lid and great irritability of the nerves generally, . [120.]
EAR
- External.
- Pain behind the left ear, as if the gland were swollen, 41.
- Tearing behind the right ear, in the region of the articulation of the lower jaw; the place was painful to touch for some time, 52.
- Internal.
- The ears feel stopped, with roaring in them, if he takes a few steps about the room, 51.
- Right ear feels stopped (fourth day), 26.
- Earache, then sticking as with needles in the ears, deep in, 52.
- Digging in the right ear, soon, 33.
- Pinching pains in the ears, 51.
- Twinging sticking in the left ear, 52. [150.]
- Stitches in the left ear, 41.
- Transient stitches in the left ear (after seven hours), 39.
- Tearing in the right meatus auditorius, 51.
- Itching deep in the ears; inclination to bore into the ears, which were internally very dry; boring does not relieve the sensation, and does not even reach the itching painful spot, 35.
- Hearing.
- Difficult hearing, 20.
- Ringing in the right ear, 33.
- Roaring in the ears, 31.
- Great roaring in the right ear, 73.
NOSE
- Objective.
- Sneezing (soon after taking), 52.
- Catarrh in the nose and fauces (fourth day), 37. [160.]
- Violent coryza, 35.
- Obstinate coryza, which is never thin, and with which much tough mucus is discharged from the nose, 52.
- Decided fluent coryza (fifth day), 37.
- Transient fluent coryza (second to fourth days), 25.
- Epistaxis, in the evening, 51, 73.
- Subjective.
- Nostrils dry and blackish, 20.
- Slight irritation to sneeze, 71.
- Sensation in the mucous membrane of the nose as of commencing coryza, 71.
- Sensation of warmth and crawling within the nose, as in nosebleed (after a quarter and half an hour), 54.
- Pinching sensation in the upper part of the nose, 52. [170.]
- Pressure and tearing in the nostrils, 71.
- Pressure in the nasal bones, 71.
- Pressure in the bones of the nose and face, 71.
- Sensation in the nasal bones, as from the pressure of a weight (after one hour and a half), 54.
- Sore pain in the septum of the nose, in the right nostril; especially violent on touching the spot, and on moving the nose, 52.
- Crawling in the nose, 52.
- Crawling in the nose, with sneezing, 52.
- Crawling in the tip of the nose, 54.
- Smell.
- Smell became very acute, 11.
- Smell so acute that the laboratory work was almost unendurable, 10. [180.]
- The sense of smell is so morbidly acute, that the odor substances to which he was usually quite indifferent, as, for example, broth, nauseates him, 51.
- The odor of a freshly beaten egg makes him almost faint (fourth day), 51.
- Smell as of smoked ham, 34.
FACE
- Objective.
- Expression very suffering, 80.
- Complaining, sad expression, 51.
- Expression of anxiety, 13.
- Face expresses great anxiety, 67.
- Paleness of the face, 48, 50.
- Very great paleness, 78.
- Face pale (second day), 32. [190.]
- Face pale and sunken, 16, 65 ; (after eighteen hours), 17.
- Face very pale, 80, 85.
- Face bluish-white, 84.
- Face sunken, 68.
- Face sunken, Hippocratic, 19.
- Features drawn, 76.
- The features are completely changed, and look as if he had been long sick (after five hours), 51.
- Subjective.
- Pain in the face, in a small spot on the right side, near the temple (fourth day), 44.
- Pain in the face, or twinges in the ears, near the right articulation of the jaw (second day), 44.
- A very unpleasant sensation in the bones of the face, as if they were widely drawn asunder; with some drawing jerkings in them, 51. [200.]
- Jerking-drawing pain in the muscles of the face, deep into the bones, 51.
- Tearing and tension in the left side of the face, extending to the ear and head, 53.
- Cheeks.
- Cheeks red and hot, 27.
- Cheeks, lips, and right eyelids purple-red, 13.
- Cheeks, lips, and eyelids purple, 67.
- Cheeks and chin alternately pale and red (after six weeks), 20.
- Sensation in both cheeks as if they would be drawn asunder, 71.
- Slight drawing in the upper jaw, on the right side, extending to the margin of the orbit, transient, and alternating with irritation in the throat (I am not subject to toothache), (after half an hour), .
MOUTH
- Teeth.
- Grinding of the teeth (after three days), 20.
- Sensation of bluntness of the teeth, with drawing pain extending from the tips of the teeth of the upper jaw into the jaw-bone, 71.
- The teeth seem too long, 71.
- Toothache; the teeth seem too long, 73.
- Painful grumbling in the upper back teeth, 52. [230.]
- (Decayed teeth became painful when chewing), (second day), 32.
- Drawing and cold sensation in the incisors of the lower jaw, 74.
- Drawing pain in the teeth, caused by taking anything cold immediately after something warm (after two hours and a half), 54.
- Pressive toothache in the left lower back teeth, 52.
- Stitches in the teeth of the right side, 41.
- Tearing in the roots of the left lower teeth, 52.
- Toothache, making the teeth sore, 52.
- The teeth are so sensitive that he is unable to bite upon them, 51.
- Gums.
- Follicular inflammation of the gum, about the right incisors, 38.
- Tearing in the right lower gum, 35. [240.]
- Tearing in the gum of the left lower front teeth, 52.
- Tearing in the upper part of the gum, in the upper part of the right side of the mouth, above a hollow tooth, 52.
- Tongue.
- Tongue very white, 85.*
- Tongue pale-blue, and cold, 72.
- Tongue very yellow, 65.
- Tongue, red, covered with mucus, 49.
- Tongue bright-red, coated only at the root, 19.
- Tongue coated in the morning, 11.
- Tongue somewhat coated in the morning, 10.
- Tongue coated white (second day), 32. [250.]
- Tongue thickly coated yellow (after eighteen hours), .
THROAT
- Objective.
- Perceptible pulsation in the carotids (after nine hours), 39.
- Inflammation of the whole throat, 51.
- Much mucus collects in the throat; it has a greenish look when expectorated, 52.
- Frequent hawking of scanty mucus, 39.
- Subjective.
- Dryness of the throat (after two hours), 38, 48, 50.
- Dryness and scraping in the throat, 34.
- Some dryness in the throat, 27.
- Great dryness in the throat, as if painful on swallowing, like a commencing catarrh, 35. [300.]
- Scraping dryness in the throat, 34.
- Sensation of dryness in the throat; the uvula, as well as the arches of the palate, is slightly red (first day), 26.
- Scraping dry sensation in the throat, with tickling cough (after half an hour), 46.
- Constriction of the throat, 58.
- Pinching in the posterior portion of the throat, as in commencing angina; with great dryness in the throat, and somewhat impeded swallowing (second day), 44.
- Tearing far back in the throat, more on the left side, 52.
- Rawness in the throat, with a hoarse voice, in the morning, 52.
- Constant crawling in the thorax, with loosening of thin mucus, so that it must be frequently expectorated, 52.
- Severe crawling in the throat, which provokes a hacking cough and hawking of mucus, 52.
- Biting crawling in the back of the throat, 52.
- Uvula. [310.]
- Uvula painful and red, 27.
- Burning in the uvula, soon followed by profuse pale urine (after a few minutes), 2.
- Pharynx and Œsophagus.
- Slight constriction of the pharynx, 71.
- Burning heat in the pharynx and along the œsophagus, 77.
STOMACH
- Appetite.
- Increased appetite (after four hours), 27, 45.
- Appetite increased, at noon (first day), 33. [320.]
- Appetite for dinner increased (second day), 32.
- Great appetite, 31.
- Great appetite, in the evening (first day), 25.
- Appetite was very voracious during the whole proving, 26.
- Enormous appetite (third day), 25.
- Hunger in the afternoon (first and second days), 25.
- Sensation of hunger, soon, 28.
- Sensation of gnawing hunger; almost a throbbing in the stomach (after a quarter of an hour), 44.
- Appetite diminished, 11.
- Loss of appetite, 7, 51 ; (third day), 5. [330.]
- Entire loss of appetite, 3.
- No appetite for breakfast, 10.
- He has appetite for different things, but as soon as he sees them, or still more, smells them, he shudders from nausea and is unable to eat anything, 51.*
- Thirst.
- Thirst (soon), 20.
- Thirst increased, 10, 11.
- Much thirst, 58.
- Great thirst, 84, 85 ; (after four hours), 82.*
- Great thirst, in the afternoon, 74.
- Excessive thirst, 3, 79.
- Extreme thirst, with the most violent pain in the stomach and bowels, 21. [340.]
- Unquenchable thirst, 17, 19, 65 ; (after fifteen hours), , etc.
ABDOMEN
- Hypochondria.
- Increased secretion of bile, 69.
- The secretion of bile was constantly increased after Colchicum, as shown not only in the stools, which were always very bilious and copious, but also in the bilious vomiting, 22.
- Pain, as from incarcerated flatus, immediately under the short ribs of the right side, 52. [460.]
- Inability to sleep, on account of not being able to lie on the left side according to habit; it constantly seemed as though a fold, or something of that kind, pressed against me; this however, was not the case, and I found that a pain in the region of the spleen was the cause, and that it was especially noticed on external pressure, 34.
- Tensive sensation transversely across the hypochondria (after four hours and a half), 39.
- Slight sticking in the left hypochondrium, 39.
- Tearing in the left hypochondrium, 34.
- Cutting-tearing pains in the hepatic region, 34.
- Transient stitches in the spleen in the evening (first day), 33.
- Umbilical.
- Sharp pressing-outward pain above the navel, somewhat to the left side, 52.
- Violent sharp stitches in the umbilical region, 52.
- Pressive colic about the umbilical region, with flatulence, before and at the commencement of the midday meal, 52.
- Sticking colic here and there below the umbilical region, 52.
- General Abdomen. [470.]
- Abdomen distended (third day), 33.*
- Abdomen distended, tense, and hard, 19.
- Abdomen greatly distended, 85.
- Great distension of the abdomen, 63.
- Great distension of the abdomen, as if she had eaten too much , although she had not taken the slightest food; after taking a moderate amount of very light food this sensation became much more troublesome (after three hours), 55.*
- The abdomen became extremely distended in a short time, 62.
RECTUM AND ANUS
- Rectum.
- Prolapsus of the rectum, 63.
- Sensation as of diarrhœa, preceded by cutting pain, without watery or thin evacuations, 35.
- Slight throbbing smarting in the rectum, 39.
- Anus. [550.]
- Spasms in the sphincter ani, with chilliness running up the back, followed by urging to stool without being able to sufficiently evacuate the bowels, 51.*
- Sensation in the anus as of diarrhœa; copious evacuations, not thin, followed by sensation as of diarrhœa in the rectum, with sore pain in the anus, 35.
- Sensation of warmth and slight prickling in the anus, 27.
- Very painful anus, 63.
- Burning in the anus, 52.
- Intermitting burning in the anus, 52.
- Transient stitches in the anterior part of the anus, in the urethra, and in the left hip, 27.
- Fine sticking tearing in the anus, 52.
- Pain in the sphincter, as if it would be torn, with a hard stool, 35.
- Crawling and violent jerking in the anus, 52. [560.]
- Sudden severe itching in the anus, 27.
- Urging.
- Urging to stool in the afternoon, followed by an evacuation which was extremely painful, and had to be accomplished with great care, since it seemed as though the whole sphincter would be torn asunder, 35.
- Urging to stool, relieved by frequent passage of flatus, 27.*
- Urging to stool, with rumbling in the abdomen and pressure in the epigastric region (after eight hours), 71.
- Urging to stool, with passage of flatus (third day), 27.
- Urging to stool, with passage of some hardened fæces, or even no passage at all, with pain in the anus, several times during the day, 54.
- Considerable urging to stool, which is unsatisfactory, 38.*
- Much urging to stool, which is difficult to pass, though soft, and is followed by pain in the small of the back (fifth day), .
STOOL
- Diarrhœa.
- Diarrhœa consisting of mucus like rice-water, 84. [580.]
- Incessant diarrhœa, 63.
- Bilious diarrhœa, afterwards mixed with white membranous pieces, 14.*
- Watery diarrhœa, 51.
- Severe purging of bilious fluid (after three hours), 83.
- Dysentery; the evacuations slimy and bloody, with tenesmus, 68.*
- Frequent stools, 9, 66.
- Frequent stools and vomiting, 18.
- Frequent stools, alternating with vomiting, 18.
- Frequent liquid stools, with gripings in the abdomen, 76.
- Stools watery, frequent, 85. [590.]
- Stool frequent, offensive, consisting of orange-yellow slimy fluid, mingled with many bright yellow flakes, without any fæces, 17.*
- Frequent evacuations from bowels, with pain; discharges large and watery; colored with bile resembling the matter vomited (after four hours), 82.
- Several large watery evacuations, accompanied by severe griping pain at each discharge (after four hours), 82.
- Two stools during the first night, 28.
- Two unusually easy stools (second afternoon), 25.
- Two pasty stools during the day (third day), 37.
- Four yellow, watery stools (first day), 5.
- Stool and urine passed involuntarily (after three days), 20.
- Stool often involuntary during the first night, but not bloody, 21.
- Frequent watery stools, without any sensation, 51. [600.]
- Stools profuse, liquid, becoming involuntary before death, of a black color, and of an extremely offensive odor, 67.
- Copious yellowish watery stools, 69.*
- Stools yellow, bloody, thin, 80.
- Stools watery, yellow, .
URINARY ORGANS
- Urethra.
- Burning through the whole urethra, with slight contraction of the neck of the bladder on urinating (after nine hours), 71.
- Slight burning in the urethra (third day), 33.
- Violent burning in the urinary passages, 63.
- Intolerable crawling burning in the urethra, in the morning, in bed, after urinating, with sensation as though more urine would pass, and burning when passing a few drops, as if it were glowing hot; together with burning in the anus (same pain repeat after eight days, also in the morning, in bed), 52.
- Burning sensation in the urethra, as if it were sore, on urinating, 51.
- Drawing and tearing in the urethra, 51.
- Pressive drawing in the urethra, 52. [640.]
- Drawing sensation in the lowest portion of the urethra, 52.
- Drawing pain in the urethra, 51.
- Cutting in the forepart of the urethra, 52.
- Slight cutting on micturition (third day), 33.
- Tickling in the navicular fossa, 39.
- Urging to urinate, 37, 55, 70.
- Great urging to urinate, 27.
- Micturition.
- Frequent micturition, 20.
- Frequent micturition, day and night (third day), 27.
- Frequent deep-yellow urine, more profuse than usual, 39. [650.]
- Micturition more frequent than usual, 52.
- Diabetic urine was passed every half hour (after two weeks), 20.
- Increased secretion of urine, 51.
- Increased dark-colored urine, 70.
- Urine somewhat increased during the first twelve hours, with some urging therewith, 54.
- Urine copious, golden-yellow, clear, afterwards with white floating clouds (third day), 33.
- Urine profuse and hot, 27.
- Urine profuse, turbid, with a specific gravity of 1034 to 1014, .
SEXUAL ORGANS
- Male.
- Tearing in the glans penis, 52.
- Very sensitive fine pains in the left testicle, as if crushed, only noticed when stepping on the left foot; apparently caused by the jar, since it was not noticed on pressure, 34. [680.]
- Tearing in the left spermatic cord, 51.
- Excessive and unusual desire for coition (second day), 26.
- Excessive sexual desire, after eating, 27.
- Female.
- Menstruation some days too early, 41.
- Menstruation seven days, earlier than usual, 53.
- Menstruation that had just appeared, disappeared, 51.
RESPIRATORY ORGANS
- Larynx, Trachea, and Bronchi.
- While swallowing the tincture, the air-passages became irritated by it, causing a slight dry cough, 2.
- Pain in the larynx, with croupous expectoration from it, 35.
- Pressive pain in the muscles above the larynx, somewhat to the left side, internally and externally, 52.
- Scraping in the larynx (soon), 33. [690.]
- Tickling in the larynx, 33.
- Crawling in the trachea and in the chest, with cough, 52.
- Voice.
- Hollow, deep voice, 33.
- Slight hoarseness (soon), 33 ; (second day), 32.
- Loss of voice, as in cholera, 76.
- Cough and Expectoration.
- (Cough alternating with coryza), 26.
- Cough and deep respiration (second day), 25.
- Frequent easy expectoration from the larynx, of mucus in gelatinous or starchlike lumps, without any cough, 35.
- Respiration.
- Notwithstanding the transpiration from the skin and the evacuation of the bowels were increased in quantity, the carbonic acid expired by the lungs remained about the same, and, on one day, was much above the normal, 11.
- Irregular respiration (after three days), 20. [700.]
- Respiration continued intermitting; convulsions became more frequent involving, the neck and face, and the jaws became more firmly clenched, with frothing from the mouth and distortion of the eyes (after six weeks), 20.
- Desire to take frequent deep inspiration, 27.
- Difficult breathing, 63, 65.
- Difficult breathing, and great anxiety (after eighteen hours), 17.
- Dyspnœa, 63.
- Dyspnœa, and contraction of the chest, 69.
- Extreme dyspnœa, 75.
CHEST
- Feeling of orgasm in the chest, and a peculiar sensation as if something alive were working in it; frequently through the day, but especially in the evening, after eating (second day), 40.
- Transient anxiety in the chest, especially in the left side (fourth day), 71.
- Fulness and oppression of the chest (fourth day), 44. [710.]
- Sensation of fulness in the chest, with pulsations in the abdomen, 39.
- Frequent tensive sensation in the chest, 52.
- Constriction of the chest, 78.
- Some constriction of the chest, with necessity for breathing deeply (after nine hours), 39.
- Frequent constriction of the chest, with sticking and boring pains through the chest, always worse beneath the left nipple, 72.
- Sensation of constriction in the chest, 65.
- Sensation of constriction in the chest, with difficult breathing (after five hours), 17.
- Pressive pain in the chest, the whole day, 54.
- Pinching-pressive sensation in the chest, 53.
- Oppression of the chest, 84. [720.]
- Oppression of the chest, while walking (second day), 44.
- An alternating oppression of the chest (after half an hour), 54.
- Anxious oppression of the chest, lasting the whole day (after three hours), 54.
- Feeling of oppression of the chest, 75.*
- Stitches in the pectoral muscles, on moving the thorax, 33.
- Frequent stitches here and there in the chest, piercing, though without affecting respiration (fifth day), 40.
- Cutting-tearing pains across the chest, 34.
- Front.
- Drawing-boring pain, extending from the middle of the sternum to the left nipple; the pain was transient, but was felt here and there in the right side of the chest; also, though much worse in the left, it was not only not aggravated by deep inspiration, but was rather relieved; it afterwards extended over the whole chest and caused a sensation of constriction there as if a heavy weight were lying upon it, 72.
HEART AND PULSE
- Præcordium.
- Slight momentary beating, and transient stitches, in the præcordial region, 27. [760.]
- Fulness and oppression, as from stagnation of blood, in the heart, at night while lying on the left side, so that he was obliged to lie on the right side, 38.
- Pressure and anxiety in the præcordial region, 16.
- Pressure and oppression in the præcordial region, with a feeling as if he would be attacked by apoplexy, relieved by walking around (fourth day), 37.
- Transient pressure in the præcordial region, in the afternoon (first day), 26.
- Oppression of the heart, 33 ; (soon), 32.
- Oppression in the præcordial region, with slight beating of the heart (second day), 25.
- Slight oppression in the præcordial region, 27.
- Stitches in the heart, 45.
- Transient stitches in the præcordial region (soon), 33, 45.
- Tearing in the præcordial region, 52. [770.]
- Præcordial region sensitive to pressure, 49.
- Palpitation, 31, 59 ; (soon), 32.*
- Palpitation in the afternoon, 28.
- Periodic palpitation, with oppression of the heart (second day), 32.
- Palpitation, on waking (third day), 33.
- Violent palpitation, 51.
- Violent palpitation of the heart, on going to sleep (from 12th dil.), 41.
- Audible palpitation, at night, 32 ; (second day), 33.
- Some dull, irregular, seemingly suppressed beats of the heart, with a peculiar, indescribable sensation in the chest (soon), 34.
- Beating of the heart scarcely perceptible, with however, very perceptible pulsation in the abdomen, 39.
- Pulse. [780.]
- Rapid pulse, 76.
NECK AND BACK
- Neck.
- Visible throbbing in the cervical arteries, especially noticed on sitting still, 39.
- Paralysis of the muscles of the neck, so that when the child was raised up, the head fell backward, with the mouth wide open (ninth day), 20.
- Rheumatism in the neck, especially in the right trapezius, which is so painful that when he makes a wrong movement of the neck, he is obliged to cry out, lasting two or three weeks, 71.
- Great stiffness and pain in back of neck and occiput, aggravated by moving the head (third day), 83.
- Pains and stiffness in the neck and occiput (third day), 14.
- Pains in the nape of the neck, 84.
- Burning on the right side of the nape of the neck, externally, 52.
- Tensive pain in the right cervical muscles noticed externally and on swallowing (after half an hour), 54.
- Pressive pain in the upper part of the neck, beneath the ear, near the articulation of the jaws; with some soreness to the touch, 52. [820.]
- Some stitches in the cervical muscles, 51.
- Back.
- Drawing backache when lying quiet, better when moving (second day), 32.
- Tearing in the back to the left of the spine, 52.
- Dorsal.
- Pain in the scapulæ, coming from the chest; on sitting a long time (fifth day), 40.
- Very severe rheumatic pains in the scapulæ and nape of the neck, mostly tensive and pressive alternating, preventing free motion of the neck, especially turning it to the left side or stretching it far backward, 35.
- Rheumatic pain, pressive periodic; more in the scapulæ than in the nape of the neck, 35.
- Constant dull stitch on the superior left angle of the right scapula, 52.
- Violent, pressive, dull, constant stitch beneath and between the scapulæ, in the back, 52.
- Lumbar.
- Pains in the lumbar region, 54.
- Dull pressure on both sides of the lumbar vertebræ (after nine hours), . [830.]
EXTREMITIES IN GENERAL
- Objective.
- Left elbow and knee-joints swollen, hot, painful, while the right side was partially paralyzed and nearly devoid of sensation, 20. [850.]
- Toes and fingers painfully flexed at times (after eleven hours), 83.
- Slight twitchings in the limbs, 85.
- Jerkings, as from electric shocks, in all the limbs, especially in the metatarsal joints (after twenty-four hours), 71.
- Trembling of the limbs that increased to an attack of violent convulsive movements (after eight hours); three hours later, a similar paroxysm occurred, ending with two attacks of vomiting, 20.
- Trembling in the extremities; these motions became more violent and convulsive, with flow of much whitish froth from the mouth; the attack was after a quarter of an hour similar to opisthotonos; after a quiet sleep, from 11 to 2 at night, another attack of a similar kind and duration, 20.
- Weakness of the limbs, so that she was unable to walk, 79.
- Weakness in the limbs, in the morning, 28.
- Great weakness, faintness, sleepiness and prostration in all the limbs, with disinclination to work, 11.
- Paralysis of the right foot and left arm, 20.
- The limbs feel weary in the morning, 74. [860.]
- Feeling of weakness and prostration throughout the limbs, 73.
- She experienced such great weakness in the muscles of the extremities, that she thought she would fall, 51.
- On attempting to walk, the limbs seem to have lost their power, 67.
- Numbness of feet and hands, succeeded by a prickling feeling, as if "they had been asleep" (after eleven hours), 83.
- Uneasiness in all the limbs, at night (fifth day), 36.
- Pain in the limbs, 84.
- Pains in all the limbs, 77.
- All the joints of the fingers and toes, and also the wrists and ankles, were very painful (after eleven hours), 83.
- The most remarkable feature of the case was the intense rheumatic kind of pain in the hands and feet, which began first, and continued during the origin and progress of the affection, becoming very severe, so much so that she could not bear to have her finger-joints pressed nor extended from their semiflexed condition, .
SUPERIOR EXTREMITIES
- Objective.
- Right arm and hand paralyzed, with the thumb drawn inward, the rest of the fingers being spasmodically closed over it (after four weeks), 20.
- Subjective.
- Sensation of weakness in the right arm, at noon, 33.
- The left upper and forearm felt lame, weakened, 27.
- Sensation of paralysis in the whole of the left arm, 71.
- Arms feel heavy, 73.
- *A paralytic pain in the arms, so violent that he cannot hold the lightest thing firmly, 51.
- Tearing in the arms, with paralyzed sensation, 73. [880.]
- Cutting-tearing pains in the left arm, 34.
- Shoulder.
- Pain in the shoulder-joint (second day), 14.
- Pain in shoulder-joints, followed by pains in hips and loins; it increased in intensity so that she said she thought she should go mad (after eleven hours), 83.
- Pinching pain on the left shoulder, 52.
- Tearings in the right shoulder (second day), 33.
- Dull tearing pressure in the right side beneath the axilla, 52.
- Frequent tearing-pressive pain, now in the right, now in the left axilla, 52.
- Tearing in the right shoulder and right forearm, 71.
- Transient stitches in the right shoulder (after five hours), 39.
- Pain in a small spot beneath and almost in the right axilla, as after a blow, 52. [890.]
- Severe bubbling sensation in the left axilla, even perceptible externally, 52.
- Arm.
- Sensation of pressure in the left upper arm above the elbow, which, during the afternoon, became a violent pain on moving the arm, especially on raising it, so that it was impossible to put on my coat alone; not felt when at rest, nor during the night, 42.
- Burning-pressive pain on the inner side of the left upper arm near the axilla, 52.
INFERIOR EXTREMITIES
- On attempting to walk, it seems as though he would lose the use of his limbs, 13.
- Hip.
- Slight snapping in the left hip, 27.
- Sensation as of something living in the left hip, 27. [940.]
- Pains in the hips and loins (third day), 14.
- Drawing in the hip-joints (soon), 33.
- Slight drawing pain in the hip-bone, on moving about at night (second day), 32.
- Pinching pressure on and above the right hip, 52.
- Transient stitches in the hips, especially in the left, 27.
- Tearing in the region of the hip, 52.
- Slight tearing in the right hip-joint, extending through the thigh to the knee (after seven hours), 71.
- Drawing tearing deep in the region of the left hip, which seems to have its seat in the ligaments; worse at night, 51.
- Thigh.
- Thighs abducted, 80.
- Stiffness of the left thigh, making walking difficult, 71. [950.]
- Pinching in the thigh like a cramps, as if it were asleep, 52.
- Drawing deep in the muscles of the thigh, 51.
- Drawing pains in the left femur, at times worse, at times better, as from excessive fatigue, or like growing pains, 34.
- Sudden sticking-drawing pain beneath the left nates, extending into the perineum, lasting half a minute, 39.
- Severe paralytic drawing in the whole of the right thigh, in the evening in bed, 52.
- Pressure upon the bones of the thighs; the middle portion is especially painful, 35.
- Tearing in the thigh, extending towards the hip, 52.
- Tearing in the upper part of the left thigh, 52.
- Tearing high up on the inner side of the right thigh, 52.
- Tearing deep in the nates towards the anus, 52. [960.]
- Tearing in the middle of the left thigh, in the evening, in bed, 52.
- Jerking-like tearing in the upper portion of the right thigh, .
GENERAL SYMPTOMS
- Objective.
- The solid constituents of defibrinated blood were diminished, as also was the absolute amount of blood-corpuscles and of the plasma, 22. [1010.]
- The quantity of colored corpuscles in the blood was somewhat diminished, 11.
- The gait is very unsteady and tottering, partly on account of weakness, and partly on account of sudden sticking-tearing jerks which shoot through the periosteum, always with a sensation of paralysis, and with actual transient paralysis, 51.
- Stretching, 39.
- Convulsions; the right arm could not be extended, the left could not be flexed; both feet were drawn upward; the soles formed a half circle, and the toes were spasmodically drawn inward (after seven weeks), 20.
- Convulsions of the left side and muscles of the face (tenth day), 20.
- The patient gradually developed convulsions, in which the extremities were spasmodically flexed; fingers and toes flexed; the eyes convulsively rotated; the left hand, which constantly kept hold of the penis, trembled; the convulsions became more and more frequent, extending to the muscles of the neck; the lower jaw became firmly pressed against the upper; and the patient frothed at the mouth, 20 . [The remaining symptoms noted during the progress of this case, subsequent to the administration of antidotes. Tartar emetic, Ipecac, etc., have not been taken.]
- Weakness, 39.
- Weakness, as after exertion, 55.
- Weakness and weariness the whole day, disappearing in the evening, 13 ; (fifth day), 10.
- Great weakness in the morning, 37. [1020.]
- Great weakness and exhaustion, 69.*
- General weakness, 39 ; (soon), 33.
- Sudden sinking of the strength, so that after ten hours he was scarcely able to speak or walk across the room, 51.
- Painful loss of power in the muscles, especially about the knee-joints, so that the knees frequently give way, particularly on raising the leg to step over a high object, as for example, over a doorstep, 51.
- He is quite powerless, and the whole body feels paralyzed, especially the arms, 51.
- Exhaustion, .
SKIN
- Objective.
- Paleness of the skin, 77.
- Skin livid, dry, and hot (second day), 20.
- The whole body became scarlet-red (after a few hours), 20.
- Eruptions.
- Pityriasis on the inner surface of the left thigh and corresponding portion of the scrotum (after one month), 37.
- (During this proving two dry wartlike pimples on the nape of the neck, lasting six weeks, and disappearing with desquamation), 32.
- A small round ulcer on the vermilion margin of the lip, 34. [1070.]
- Sticking in the skin, so that it jerks through the whole body, 51.
- Violent jerking stitches, as from fleabites, in various places, obliging me to scratch, and then disappearing, 34.
- Itching over the whole body, 30.
- Itching over the whole body, as from burning nettles or from jelly-fish, 61.
- Itching of the skin in various parts of the body, 51.
- Burning itching in small places here and there; after scratching the skin becomes red, and the itching changes to another place, 34.
- Sticking itching in various parts of the body (first day), 34.
- Very burning sticking-itching, here and there, in the skin, obliging scratching, whereby it was driven to another part, 34.
- Crawling on the inner surface of the great, second, and third toes of the right foot, as if they were asleep, 52.
- Itching and eruption on the face, 56. [1080.]
- Sensitive itching of the skin of both forearms on the ulnar side, where, without scratching, the skin becomes red, 71.
- Obstinate itching of the hands, 56.
SLEEP AND DREAMS
- Yawning, 39.
- Yawning, with rumbling in the abdomen, after dinner, followed by very copious stool (second day), 46.
- Repeated yawning (soon), 32.
- Was frequently obliged to yawn, 51.
- Sleepiness during the day, 51.
- Sleepiness; disinclination to work; with confusion of the head (after half an hour), 54.
- Unusual sleepiness in the afternoon (first day), 33 ; (second day), 32.
- Unusual sleepiness in the evening (first day), 32. [1090.]
- Excessive sleepiness soon after supper (after five hours), 27.
- Overpowering sleepiness in the afternoon, 35.
- Very sleepy till midnight, then waking with sensation of heavy oppression in the stomach, after which he was wide awake for two hours, 32.
- Unusually strong desire to sleep (third night), 25.
- Irresistible desire to sleep in the evening (first day), 25.
- At night deep sleep, with vivid dreams and grinding of the teeth, 32.
- Soporous condition for two hours and a half, 12.
- The child was found in a soporous condition, lying on its back in bed, with half open eyes and loud respiration, 19.
- Sleeplessness.
- Sleeplessness, 76.
- Uneasy sleep, 55. [1100.]
- Uneasy sleep, with anxious dreams (third day), 26.
- Sleep uneasy, unrefreshing, 74.
- Sleep very uneasy (second day), 30.
- Afternoon nap on the sofa very uneasy, only slightly refreshing, 10.
- The afternoon nap did not refresh him, 11.
- Sleep restless and exhausting, 71.
- Sleep restless, with many dreams, 39.
- Very restless night, with heavy dreams, 28.
- Frequent waking from sleep in fright, with the idea that there were mice in the bed; two nights in succession, 52.
FEVER
- Chilliness.
- Temperature diminished, 16.
- Cold temperature of the skin, 17.
- Skin cool, 65.
- Cold skin and tongue, 69.
- Skin tongue, and breath cold, 68.
- Chilliness (soon), 33 ; (second day), 32.
- Chilliness in the room, 29.
- Chilliness the whole day, 10.
- Chilliness of the whole body, even in the room, 34. [1120.]
- Chilliness the whole day, lasting till 7 P.M., 11.
- Chilliness in the afternoon (second day), 40.
- Chilliness in the open air in the afternoon (first day), 25.
- Chilliness in the room, soon afterwards vertigo, 28.
- Chilliness and heat alternating, 65.
- Chilliness and heat alternating, 17.
- Chilliness, with heat of the head at night (second day), 32.
- Constant chilliness (second day), 32.
- Constant chilliness in the afternoon (second day), 32.
- Coldness in the afternoon after dinner (third day), 10. [1130.]
- General coldness, 77, 78.
- Progressive coldness, 75.
- Sensation of coldness, 45.
- Sensation of coldness in the evening relieved by warm coverings, but returning on going to bed as a chilliness, with chattering of the teeth, disappearing after a short time while lying still; to bed as a it threatened to return on motion, 35.
- General lack of warmth in the body, even in bed, 34.
- Chilliness in the scalp, 45.
- Chilliness in the knees, 34.
- Slight chilly sensation in the abdomen, especially in the stomach, with pain and weakness, 51.
- Shivering in the back (second day), 33.
CONDITIONS
- Aggravation.
- ( Morning ), Confusion in the head; after rising, especially on shaking head, feeling in head; on waking, pain in right forehead; tongue coated ; rawness in throat, etc.; on waking, nausea, etc., pain in stomach; on waking, pressure in upper abdomen; diarrhœa-like stool; in bed, burning in urethra; in bed, stitches in left chest; on waking, palpitation; on waking, drawing in small of back; bruised feeling in small of back; weakness of limbs; limbs feel weary; drawing in muscles of shoulders, eyes; weakness; on waking, weariness; on rising, weariness.
- ( Forenoon ), Eructations.
- ( Afternoon ), Frontal headache; towards evening, headache from forehead towards occiput; hunger; thirst; urging to stool; slimy stool; pressure in præcordial region; palpitation; pressure in sacrum, especially immediately after dinner; sensation in whole body; sleepiness; chilliness ; after dinner, coldness; cold feet; flushes of heat.
- ( Evening ), Headache ; headache in temple; pressure in temple; epistaxis; great appetite; while walking, pain in stomach; stitches in spleen; pain in abdomen; after eating, feeling in chest; in bed, drawing in thigh; in bed, tearing in middle of thigh; in bed, knee-joint painful; in bed, pain above knee; pain in whole body; griping, etc.; in toes; pains become intolerable; sensation of coldness.
- ( Night ), From beginning of night to break of day, all the varieties of pain; delirium; great flow of thoughts; colic, etc.; about 10 o'clock, pains in left chest; while lying on left side, fulness, etc., in heart; audible palpitation; pain in sacrum; uneasiness in all limbs; on moving about, pain in hip-bone; tearing in region of hip; towards morning, lascivious dreams; chilliness, etc.; heat of body; dry heat; sweat.
- ( After midnight ), After waking, slight sweat.
- ( Open air ), Lachrymation.
- ( Bending forward ), Heaviness in occiput.
- ( Bending head backward ), Headache in occiput.
- ( On blowing nose ), Pain in left chest.
- ( Coffee ), Aggravation.
- ( During dinner ), Nausea.
SUPPLEMENT: COLCHICUM. Authorities.
86 , J. Y. Clark, M.D., Am. Med. Rec., vol. i, 1818, p. 369, John R. Peckworth took 100 drops of tincture; 87 , ibid., the author took 100 drops; 88 , Thos. Kennard, M.D., Am. J. of M. S., 1857 (1), p. 69, a woman, æt. fifty-six years, took one ounce of Colch. wine in twelve hours; 89 , Dr. Fifield, Bost. Med. and Surg. Journ., vol. lvi, 1857, p. 78, a man, æt. twenty-eight years, suffering from rheumatism, took half an ounce of Colch. wine; 90 , W. A. Hammond, M.D., Am. Med. Monthly, Feb., 1861, p. 83, took 1 fluid drachm at 8 A.M., 2 and 10 P.M. (first day); 1 1/2 fluid drachms three times (second and third days); 1/2 drachm (fourth day); 1 1/2 drachms (fifth day); 91 , ibid., a man, æt. twenty-three years, took 1 drachm tincture three times (first day); 1 1/2 drachms three times (second day); 92 , John H. Garner, M.D., Canada Lancet, vol. iii, 1871, p. 307, R. H. drank about a pint of tincture; 93 , ibid., J. M. J. took same quantity; 94 , ibid. T. H. took a small quantity; 95 , W. E. Porter, Med. Times and Gaz., 1874 (2), 723, poisoning of two children, æt. four and two years; 96 , Canada Pharm. Journ. (Pacif. M. and S. Journ., April, 1874, p. 572), a party of seventeen persons drank from one or two ounces to a pint each, of the wine, seven died; 97 , J. Pierre, Comptes Rendus, vol. lxxix, p. 633 (Pharm. Journ. and Trans., Oct., 1864, p. 325), the author plucked some fully expanded flowers, afterwards extended his hand over a large clump of flowers, carefully avoiding all contact, with the same result.
MIND
HEAD. [1190.]
- Intense headache, 92.
EYE
- Eyes red and watery, and the pupils dilated, 92.
EAR
- Much tinnitus aurium, 92.
FACE
MOUTH
- Tongue dry and brown in the centre, and red along the edges, 92.
STOMACH
- Great thirst, 92, 95.
- Nausea, 94.
- Sickness, 95.
- Vomiting in from three-fourths of an hour to an hour and a half, 96. [1200.]
- The ejecta were bilious, and then of the rice-water character, 96.
ABDOMEN
- Extreme tenderness over abdomen, and the intermittent severe pains precisely similar to peritonitis, 92.
- Tormina, 95.
RECTUM AND ANUS
- Tenesmus, 95.
STOOL
- Purging, 96.
- Severe diarrhœa (second day), 91.
- Purged and vomited violently, 92.
- Purging in from three-fourths of an hour to an hour and a half, when a large quantity was taken; later when the quantity was small, 96.
URINARY ORGANS
- In three days immediately preceding commencement of experiment, the average quantity of urine for each day was 1425 cubic cent. of sp. gr. 1021.73. The average amount of solid matter was 64.28 grams; of which 30.18 were inorganic, and 34.10 organic substance. The average amount of uric acid excreted for each period of twenty-four hours was 0.77 grams. Quantity of urine excreted 1685 cubic cent., sp. gr. 1021.5; total amount of solids 70.15 grams, of which 30.90 were inorganic, and 39.25 organic matter; quantity of uric acid 0.81 gram (first day). Quantity of urine 1720 cc., sp. gr. 1020.87; total solids 75.29 grams; inorganic solids 32.44 grams; organic solids 42.85 grams; uric acid 0.69 grams (second day). Quantity of urine 1784 cc.; sp. gr. 1022.57; total solids 80.13 grams; inorganic salts 35.11 grams; organic solids 45.03 grams; uric acid 0.82 gram (third day). Quantity of urine 1540 c.c.; sp. gr. 1023.17; total solids 69.23 grams; inorganic solids 31.09; organic solids 38.14; uric acid 0.78 gram (fourth day). Quantity of urine 1698 cc.; sp. gr. 1023.68; total solids 76.14 grams; inorganic solids 32.36 grams; organic solids 42.88 grams; uric acid 0.76 gram (fifth day), 90.
- Average daily quantity of urine 989 cc.; sp. gr. 1020.14; total solids 51.20 grams; inorganic solids 22.45 grams; organic solids 28.75 grams; uric acid 0.47 gram (before experiment); quantity of urine 1021 cc.; sp. gr. 1024.18; total solids 63.25 grams. inorganic solids 23.57 grams; organic solids 40.68 grams; uric acid 0.59 gram (first day); quantity of urine 8875 cc.; sp. gr. 1026.11; total solids 60.25 grams; inorganic solids 20.38 grams; organic solids 39.87 grams; uric acid 0.51 gram (second day), 91.
RESPIRATORY ORGANS. [1210.]
- Coughed severely at regular intervals, 92.
- Blood in sputa, 92.
- Breathing rapid; heavy, almost stertorous (after a few hours), 92.
CHEST
- Great fulness of the chest, 92.
PULSE
- Pulse 80 (before experiment); 78 (in five and ten minutes); 76 (in fifteen and twenty minutes); 78 (in twenty-five and thirty minutes); 80 (in thirty-five, forty, and forty-five minutes); 78 (in fifty minutes); 76 (in fifty-five minutes); 72 (in sixty minutes); 70 (in sixty-five minutes); 68 (in seventy and seventy-five minutes); 72 (in eighty and ninety-five minutes); 70 (in one hundred minutes); 72 (in one hundred and five, one hundred and ten, and one hundred and fifteen minutes); 76 (in one hundred and twenty minutes); 80 (in one hundred and eighty and two hundred and forty minutes), 86.
- In five minutes after taking the medicine, his pulse became considerably reduced, both in force and frequency; in thirty-five minutes he had a copious discharge of pale-colored urine, his pulse much increased; in fifty minutes, very sleepy, pulse again reduced; in seventy minutes, his mental faculties became much exhilarated, pulse very slow and soft; in ninety minutes, perfectly free from any peculiar feelings, pulse somewhat increased; in one hundred and eighty minutes, pulse very natural, 86.
- Pulse 70 (before experiment); 52 (in five minutes); 48 (in ten minutes); 46 (in fifteen minutes); 42 (in twenty and twenty-five minutes); 48 (in thirty minutes); 43 (in thirty-five minutes); 45 (in forty and forty-five minutes); 39 (in fifty minutes); 43 (in fifty-five minutes); 46 (in sixty minutes); 50 (in sixty-five, seventy, and seventy-five minutes); 45 (in eighty, eighty-five, and ninety minutes); 47 (in ninety-five minutes); 50 (in one hundred, one hundred and five, one hundred and ten, one hundred and fifteen, one hundred and twenty, and one hundred and twenty-five minutes); 53 (in one hundred and thirty minutes); 55 (in one hundred and thirty-five minutes); 57 (in one hundred and forty minutes); 60 (in one hundred and forty-five, one hundred and fifty, one hundred and fifty-five, one hundred and sixty, and one hundred and sixty-five minutes); 65 (in two hundred minutes); 70 (in two hundred and seventy-five and three hundred minutes), 87.
- In five minutes after taking the medicine my pulse became diminished, both in force and frequency; in fifteen minutes I felt considerable flushes of heat passing over my face, and followed by a considerable degree of vertigo; in fifty minutes, my pulse became still more diminished; in sixty-five minutes, I was somewhat sleepy; and in seventy-five minutes, I was very sleepy, attended with a slight diaphoresis; in one hundred and thirty minutes, my pulse began to increase in frequency, but continued diminished in force; and in two hundred and thirty-five minutes, was natural, both as to force and frequency, 57.
- Pulse 160; grew feeble (after a few hours), 92.
SUPERIOR EXTREMITIES
- Numbness in the arms, 97. [1220.]
- In a few seconds his fingers changed color, and took the livid greenish tint characteristic of a corpse in a state of incipient decomposition. After about ten seconds the skin regained its color, 97.
- Cramps of the fingers, 96.
GENERALITIES
- Convulsions, 95.
- Extreme prostration, suffering from excessive nausea and vomiting, with slight purging, heat and burning in the fauces, inordinate thirst, cold, clammy skin, feeble pulse, violent supra orbital pain, and distressing gastralgia, with very anxious countenance, 88.
- Pale, cold, vomiting constantly, purging, and complaining of great thirst and pain at the epigastrium, 89.
- The symptoms were mainly those of violent cholera morbus, 96.
- Debility, 94.
- Very much exhausted, 92.
- Similar symptoms, but milder, except the headache, which he described as most intense, 93.
SLEEP
- Insomnia, 96.