COCA.

Erythroxylon coca, Lam.

Natural order , Lineæ (suborder, Erythroxylæ).

Preparation , Tincture of leaves.

Authorities.

1 , Rauch, aged 45, took 2d dec. dil., first day; 1st dil., second day; 2d dil., third day (from Dr. Clotar Muller's compilation, Hom. Viertljhrschft., 7, 443); 2 , Reichenbach, aged 35, took 2d and 1st dec. dils.; 3 , same prover took tincture, 10 to 60 drops; 4 , Kallenbach, aged 27, took 50 drops of tincture at one dose; 5 , Dr. Muller, aged 38, chewed a leaf and took 2 and 3 drops of tincture; 6 , same prover, second proving chewing two leaves and taking 5 to 60 drops of tincture; 7 , R. H., aged 26, chewed four or five leaves at different times for eighteen days; 8 , Hermine Pekarek, girl, aged 9 1/2, took 10 and 15 drops tincture, repeated doses; 9 , Poppig, effects of infusion, etc., "Journeys in Chili and Peru;" 9 a , Archibald Smith, from Poppig's "Journeys;" 10 , Tschudi, general effects observed in Coca chewers; 11 , Dr. Frankl, effects of infusion, A. H. Z., Mon. Bl., 1, 48; 12 , Stokes, provings with tincture, 10-drop doses, M. Hom. Rev., 3, 163; 13 , Drysdale and Stokes, effects of chewing leaves, ibid.; 14 , Isaac Ott, proving with 1 drachm of leaves at each meal, first day; 2 drachms, second day, Phil. Med. Times, March, 1870; 15 , Berridge, proving with C. M. (Fincke), N. Am. J. of Hom., N. S., 3, 505; 16 , Berridge, provings with 21st dil. and 3 drops tincture, from Hering's monograph; 17 , Croker, proving with 21st dil., ibid.; 18 , Sarah A. Ferguson, took infusion, ibid.; 19 , Carl Haller, from ibid.; 20 , Caroline Lebeau, ibid.; 21 , Lilienthal, took tincture, 3d and 30th dils., ibid.; 22 , Montegazza, from ibid.; 23 , omitted; 24 , Pope, effects of chewing leaves and of infusion, ibid.; 25 , Ray, effects of 21st dil., ibid.; 26 , omitted; 27 , Scheibler, effects of 21st dil. and tincture, ibid.; 28 , Safford, provings, from ibid.; 29 , Searle, from ibid.; 30 , Addie Williams, effects of tincture and infusion, ibid.; 31 , omitted; 32 , Weddell, from ibid.; 33 , omitted; 34 , Johnston, Chemistry, from ibid.; 35 , omitted; 36 , Scherze, "Journeys," from ibid.; 37 , Schlechlendal, from ibid.; 38 , W. R. Scott, from ibid.; 39 , "H.," from ibid.; 40 , N. N., from ibid.; 41 , A. Haller, from ibid.; 42 , George Gassett, from ibid.; 43 , A. Marvaud, effects of chewing leaves, of cold infusion, and of subcutaneous injection of Cocaine, from "Aliments d'Épargne," p. 360, et seq.; 44 , Experiments of Demarle, from last author.

MIND

• Emotional.
• Brain excited, 12.
• Gentle excitement, followed by wakefulness (from weak tea), 34.
• Pleasant excitement, with following sleeplessness, 19.
• A peculiar aberration of the intellectual faculties, characterized by hallucinations, 32.
• Excited fantasies, wonderful visions, now indescribably beautiful and wonderful forms, now frightful images, 10.
• Passion for solitude, 9.
• Desire to isolate one's self, 9a.
• In the evening, while writing, the child groans, with irregular or difficult breathing, 8.
• Lively mood, inclination for mental work (first day), 11. [10.]
• After he felt perfectly healthy again, his spirits remained excellent, in spite of depressing circumstances, 27.
• Felt very much elated, 12.
• Felt sometimes like expectation, 12.
• Mental depression (eighth day), 18.
• Depressed and weary in the evening (fifth day), 2.
• Sadness, 9a.
• The sadness and dejection of mind of the Indians in the Peruvian Andes ought not to be ascribed to the use of ; on the contrary, the is the only thing to rouse them, at times, out of their stupidity, 19.
• When lifting anything, fear lest I should let it fall, in the morning (sixteenth day), 15.
• Great apprehension (seventh day), 7.
• Great apprehension, with violent palpitation (ninth day), 7. [20.]
• Very irritable (fifth day), 2.
• Woke this morning early, feeling ill-humored because the light came in strongly through the blind, which I had to darken. Afterwards dreamed that I was relating some joke to some friends, at which we all laughed; I actually laughed in my sleep, but on being woke immediately, could only recollect part of the joke (seventeenth day), 15.
• Very morose mood, 9a.
• General obtuseness of feeling (chronic symptom of chewers), 9.
• They turn phlegmatic while under the influence of the leaves; the most important, even dangerous, even cannot frighten them out of their state of rest, .

HEAD

• Confusion and Vertigo.
• Confusion of the head (twelfth day), 3.
• Confusion of the head in the morning; relieved after washing and drinking coffee, 8.
• Confusion of brain, vertigo in forehead, disposition to sleep, want of appetite, low-spirited, about 5 or 6 P.M., indoors (second day), 25.
• Vertigo (second day), 3. [40.]
• Vertigo, whirling (eighteenth day), 3.
• Vertigo on rapidly ascending steep steps, followed by diarrhœa once (after two hours), 2.
• Vertigo while walking, with sensation as though the body were drawn to one side (seventh day after 30 drops), 6.
• Vertigo, lasting half an hour, relieved by rest and by a glass of wine, 2.
• Vertigo and dizziness (fifth day), 3.
• Slight vertigo on moving in the open air; objects seem to turn, lasting one hour, 1.
• Transient vertigo while sitting still, and once afterwards when rising from sitting (fifteen minutes after 40 drops, eighth day), 6.
• Vertiginous feeling, preventing literary labor for about an hour, 13.
• When the head was bent forwards in writing, transient feeling of giddiness, which seemed to proceed from occiput forwards, on left side; in five minutes another similar but slighter symptom, 7.30 P.M. (eighth day), 16.
• General Head.
• Head very clear, 12. [50.]
• Headache, 9a.
• Headache is excited from sleeping near heaps of dried leaves, 9.
• Headache followed tablespoonful doses in two hours from first dose, abating somewhat before second dose, present all the afternoon, left at evening (fourth day), 18.
• Headache, leaving after eating, returning in three hours and a half, and leaving at sunset (third day), 18.
• Headache began at 10 A.M., relieved by walking in open air, but returned upon going indoors (fifth day), 18.
• (In afternoon (indoors), headache; afterwards, soon after commencing walk in open air, headache in upper part of forehead for a short time), from heat of weather (one hundred and fifty-third day), 16.

EYE

• Eyes hollow, surrounded by deep violet-brown circles, 10.
• He was chewing a leaf, in the corner, with staring eyes fixed upon the ground, automatic motion of the hands, and some dull groaning, 10.
• Slight discharge of mucus from the right, and also somewhat from the left eye, during the day (second day after 10 drops), 6.
• Pain in the eyes (fourth day), 7.
• Pressure in the eyes (ten minutes after chewing the leaf), (ninth day), 7.
• The eyes become very sensitive; reading cannot be endured long; some are troubled with slight headache, while others suffer from nausea and various disorders of the digestive apparatus, which may be compared with sea-sickness, 9.
• Brow. [100.]
• A boring pain over the right eye, 28.
• Sensation as if something were beating over the eyes (first day), 7.
• Lids.
• Heaviness of eyelids (fifth day), 18.
• Disposition on the part of the upper lids to fall, without being sleepy (ninth day), 2.
• Lachrymal Apparatus.
• Lachrymation of the right eye, with slight redness of the conjunctiva and of the lids at the inner canthus, in the morning (after 10 drops), 6.
• Pupils.
• Dilates the pupils; renders the eyes intolerant of light (after large doses), 34.
• Widens the pupils, and lessens the sensitiveness to light, 19.
• Vision.
• Momentary blackness before the eyes (such as he had formerly experienced in summer heat; on going from sunlight into a dark room), on ascending stairs (three hours after 40 drops, eighth day), 6.
• Great photophobia , with dilated pupils, 10.
• Letters swim on the paper (after ten minutes), 7. [110.]
• It is impossible to continue reading because the letters run together; fiery points float before the eyes downward (seventh day), 7.
• It seems as if he were writing with two pens (after ten minutes), .

Camphor , instead of the floating threads, only one small dark spot the size of a lentil, floating before his eyes, 27.

EAR

• Objective.
• Discovered accidentally, when washing, an excess of wax in right ear, easily removed by the towel, 7 A.M. (seventy-sixth and ninety-second days), 16.
• Subjective.
• Sensation of deafness in both ears, although everything is heard a distinctly as usual; still there is a constant sensation as though there were something in the ears which caused deafness (first day), 4.
• Slight earache in right internal ear for a few minutes (in church), 7.20 P.M. (thirtieth day); (indoors), 1 P.M. (ninety-third day); an aching pain in right internal ear, and, to a less extent, in right mastoid process for a few seconds, then in ear, only for a few seconds more (sixty-fourth day), 16.
• During loud reading in the room there was a sensation as though the tympana were pressed outwards by the tones, or as though the tones first entered the ears through a thicker medium (second day), 4.
• Hearing.
• Hearing painfully acute, during evening, 12.
• Pulsation and dull roaring in both ears, in the forenoon (second day), 4.
• Audible pulsation in both ears (first day), 4.
• Cracking in both ears, on empty swallowing (second day), 4. [130.]
• Singing in the left ear, for several minutes (first day), 4.
• Severe ringing in the ears; did not hear though one knocks three times at the door; when one speaks it seems as though the voice came from a great distance (seventh day), 7.
• Violent ringing in the ears (first day), 7.
• Violent roaring in the ears (after two hours), 7.

NOSE

• Objective.
• Sneezing several times (after three-quarters of an hour), (second day), 1.
• Sneezed after rising, and in evening (twelfth day); later days occasionally indoors, 16.
• Running of clear water from nose, and occasionally sneezing, without having properly a coryza as he usually has it; (weather warm and showery; the same next day), (nineteenth day), 27.
• Flowing from the nose of clear water, occasional sneezing, feeling of soreness in left nostril, from 6 A.M. till 5 P.M., when in the draught, though not subject to colds (twenty-second day), 27.
• Clear watery flow from nose, with small specks of blood on blowing nose (after inhalation), 27.
• Increased nasal mucus (forty-first day), indoors (forty-second day), and out of doors, in morning; scarcely any excess in afternoon or evening; at one time, in morning, heat in nose (indoors), (forty-third day), 16.
• Subjective. [140.]
• In early morning, in bed, feeling of heat and irritation in right nostril, as from catarrh (eighty-fifth day); in whole nose, especially the left nostril, before and after rising (eighty-seventh day), 16.
• In part of evening, indoors, nostrils feel rather hot internally, as after catching cold; nasal mucus less (forty-second day); later days, 6.40 A.M., heat and irritation in left nostril, as from a cold, 16.
• In evening, irritation as if from taking cold; in the night, 9 o'clock, wakened by running from nose, 16.
• During day, felt a soreness in nostrils, especially left; weather warm; after

Camphor, 27.

FACE

• Paleness of the face, 1.
• A kind of chlorosis develops; the bilious color first noticed gives place to a leaden hue, 9a.
• Cheeks.
• Burning redness of cheeks, first left, then right, with white spots in the centre of latter (sixty-fifth day), 18.
• Pressive pain in the right malar bone (first day), 3.
• Lips.
• Pale lips and gums, with green blunted teeth, 10.
• About 10.45 A.M., slight burning in left upper lip, where the mustache grows (fifty-first day), 16.
• Lower Jaw. [150.]
• Soreness in left lower jaw, just above submaxillary gland; worse on talking, and especially by eating solid food on that side (second day), 25.

MOUTH

• Greenish and stumpy teeth, 34.
• Toothache in a hollow tooth (fourth day), 7.
• Tongue.
• Tongue coated (twenty-first day), 3.
• At tip of tongue, towards right side, an appearance of a vesicle that had broken, with a red circle around it; tongue there feels sore occasionally, when eating, touching it, and at other times; at first, the soreness was as if it had been scalded with hot tea; then more like a sore place (one hundred and first and one hundred and second days); well next day, 16.
• Cocaine causes a numb feeling on the tongue, 19.
• General Mouth.
• A swelling inside right lower lip; a few days after, a similar swelling inside left cheek, at upper part, nearly opposite first upper molar; sometimes rather painful when eating (sixtieth day), flattened on two sides (that next the cheek, and the opposite one), with a thin border; red, with a whitish patch at tip on the side next cavity of mouth, as if from pus; not so painful (sixty-third day), feels smaller, somewhat semicircular; apex more pointed; getting smaller (after sixty-four days), nearly gone (eight-sixth day), 16.
• Dryness of mouth on waking , about 6.45 A.M., gone in half an hour (sixty-third day); 7.30 A.M., again after a short sleep (on one occasion, with mouth open), (eighty-ninth day); soon after waking (ninety-third day); immediately on waking (about 7 A.M.), mouth and lips, removed by breakfast (one hundred and tenth day); with disagreeable taste (one hundred and twenty-fourth day); still dry (one hundred and fifty-fourth day), 16.
• Cool feeling, verging on numbness, in the mucous membrane of the mouth and throat, similar to that after taking strong

Aconite into the mouth, 29.

• Slight burning in mouth and throat, with increased thirst, set in, 22. [160.]
• Fresh leaves burn in the mouth, like Cantharides, 36.
• Mouth and palate felt as if burnt with pepper, in morning, 12.
• Swollen sensation in the arches of the palate, which made swallowing difficult with at times tickling, causing cough, returned as in a former proving, 6.
• Saliva.
• Increased flow of saliva, first of a bitterish, later of an aromatic taste (after chewing 1 drachm of the leaves), 22.
• Taste.
• Mouth out of taste, for two hours, 3.30 P.M., again, on rising; going off after drinking cold water (seventy-eighth day), 16.
• Taste slimy (fourth day), 3.
• Salt taste at tip of tongue, 4 P.M.; about 9 P.M., transient on anterior portion of right side (twenty-ninth day); during morning, again (thirtieth day). At tip of tongue 2.45 P.M. and at 3.50 P.M.; at 7.40 P.M., over a larger portion of extremity, then on the right side of anterior part till about 9 P.M.; eating a gingerbread removed it awhile; again removed by supper, but again returned (forty-third day), 16.
• Bitter taste on waking in morning, lasting only a short time; afterwards an unusual flow of water from nose, 27.
• Bitter taste in mouth, for a minute or so, about 7.15 A.M. (tenth day), 16.
• Bitter taste on right half of tongue, for about a minute, at 12.45 P.M. (second day), 15. [170.]
• Bitter taste on right side of tongue, at 6.40 P.M. (fifteenth day), 15.
• Insipid, grapy taste of the infusion, 9.
• Water tastes burnt (twelfth day), 3.
• Butter tastes like herring (ninth day), 3.

THROAT

• Sensation of dryness in the throat (after two hours), 7.
• Soreness at back of throat on rising (thirteenth, nineteenth, and forty-first days), 16.
• Scraping in the throat, with swollen uvula; this caused frequent hawking and expectoration of mucus (second day), 6.
• Tickling at back of throat, on rising (forty-third day), 16.
• *Hawking up of small, transparent lumps of mucus, chiefly in morning (third day), third proving, 27.
• Tonsils and Uvula.
• The uvula became long and red (from chewing the leaves), 6. [180.]
• Pain on swallowing, as from soreness and swelling, in a small spot on the right side of the uvula (seventh day), 6.
• Sensation of dryness in the throat; and unpleasant sensation on swallowing, as if swollen (second morning), 6.
• Fauces and Pharynx.
• By a slight cough, loosened and swallowed some mucus from back of pharynx, 8.20 P.M. (ninety-first day), 16.
• 3 o'clock A.M., dreamed he was trying to remove mucus from pharynx by hawking; on waking, in midst of dream, found himself doing so; could not succeed by coughing or hawking; voice hoarse; cold water did not affect the throat in any way (ninety-sixth day), 16.
• Great dryness of fauces, 27.
• Feeling as if some mucus were at back of pharynx, not removed by coughing, or hawking, 11 P.M. (eighty-ninth day); still there, 8.27 (ninety-first day); gone, 8 (ninety-second day), 16.
• At back of pharynx soreness and feeling of obstruction, not removed by coughing or hawking, with hoarseness, early morning (eighty-ninth day); after rising (eighty-ninth and ninetieth days), a slight cough loosened mucus; brought up a piece of green mucus (ninety-first day). Tickling or kind of soreness when talking (the same, one hundredth day); slight cough loosening mucus (ninety-first day); after rising (ninety-second day), not removed by coughing or hawking up, which however loosened; the cough caused soreness, 16.
• Tickling at left side of pharynx when talking, 8.45 A.M. (one hundred and thirty-sixth day), 16.
• When talking, tickling at back of pharynx towards left side (ninetieth day), 16.
• Swallowing.

STOMACH

• Appetite.
• Appetite increased for last few days (one hundred and thirty-second and one hundred and thirty-fifth days), 16.
• Great appetite (after three hours), 6.
• Sudden voracious appetite, especially for animal food, contrary to usual habit, 9.
• Great hunger; dinner was eaten with appetite, even at 11 A.M., though less was eaten than on the preceding day, when he had no special hunger (sixth day), 5.
• Morbid hunger, even to swallowing animal excrements; chronic symptom of chewers, 9.
• Longing for food, although the abdomen was somewhat distended in the epigastric region, as from an overloaded stomach (second day), 1.
• Indians, after chewing all day, not eating any food, ate at night like hungry men, and sometimes at a single meal swallowed as much as would serve others two days, 32.
• Appetite diminished; could not take his usual moderate quantum of food, 12.
• Slightly diminished appetite, 14. [200.]
• Great diminution of the usually vigorous appetite; chewing the leaves suspended the sensation of hunger; though eating one-half less than usual, his weight did not diminish, nor the capacity to endure labor, 29.
• Little appetite (fourth day), 3.
• Very little appetite the first week, especially for meat, of which I was usually most fond (fifth day), 3.
• Loss of appetite, 9.
• Loss of appetite, with speedy satiety (twenty-first day), 3.
• Want of appetite; weak digestion, and nervous irritation, with headache, 9a.
• Drinking the decoction at 3 or 4 o'clock P.M., it has invariably and totally deprived him of all appetite for dinner, and of his rest at night; under these circumstances he always passed the night in reading or writing; he felt no fatigue or hunger on the following morning, 24.
• Retards approach of hunger (taken as tea), 34.
• Enables the body to feed upon itself, without the hunger-pains and weakness usually accompanying prolonged abstinence from ordinary food, 34.
• Very little need for nourishment, even during heavy work, with remarkable vigor, 10. [210.]

ABDOMEN

• Hypochondria.
• Bilious affections appear, with their numerous tormenting sufferings, common under a tropical sky; obstinate constipation, jaundice, headache, debility, emaciation, 9. [250.]
• Intense pains in region of liver; biliary affection; gallstones frequent and severe, 38.
• General Abdomen.
• Abdomen distended, tense, tympanitic, 1.
• Abdomen very much distended (eleventh day), 7.
• Abdomen very much distended, in the evening (third day), 7.
• Rumbling in the abdomen, with passage of flatus after five minutes, and continuing more or less throughout the day (second day), 1.
• Repeated rumbling in the abdomen, as from flatulence, with eructations without taste or odor (two hours and a half), 1.
• Gurgling in the ileum, extending after ten minutes to the ascending and descending colon (after twenty minutes), 1.
• Peculiar gurgling in the abdomen, with sensation of emptiness (second day), 6.
• Constant urging of flatulence, without passage of any, 1.
• On two occasions flatus from bowels, having the smell of burnt gunpowder, 8 A.M. (ninetieth day), 16. [260.]
• Passage of flatus and urging to stool (after forty-five minutes), 1.
• Profuse passage of odorless flatus, relieving the colic and the rumbling in the abdomen, 1.
• Cutting-drawing gnawing pain in the small intestines, with rumbling, commencing early in the morning, reaching its greatest severity about 9, and lasting till about 11 o'clock, relieved by rapid walking and after eating something, but returning after half an hour; the pain was relieved by repeated pressure in the mesogastric region, 1.
• Colic renewed after a cup of chocolate, 1.
• The colic is very much aggravated after taking coffee, continues throughout the day till 5 P.M., then disappears after drinking cold beer, 1.

RECTUM AND ANUS

• Wakened from sleep by great urging to stool; stool copious, solid (first night), 7.
• Urging to stool in the afternoon, followed by diarrhœa (sixth day), 3.
• 3 P.M., had urgings to stool, but evacuated only a slight quantity of clear watery mucus, with a few brownish small flocks swimming in it (second day), 27.
• Urging to stool, followed by hard, scanty stool, with sensation as if the sphincter was paralyzed, 1.
• Plagued the whole day with desire to stool, and sulphuretted hydrogen flatulency (seventh day), 21. [270.]
• No desire for stool at the usual time in the morning; no evacuation the whole day, notwithstanding every effort; awoke at 11 o'clock at night, with great urging to stool, followed by an abundant, firm evacuation, 39.

STOOL

• Diarrhœa.
• Teaspoonful mushy diarrhœa, 2 P.M. (fourth day); four stools during the early afternoon, without pain; stools different from his habitual looseness; stopped taking Coca, and had natural stools (fifth and sixth days), 21.
• Large diarrhœic stools, without pain anywhere, also frequent urination of large quantities; had to get up three times at night to pass water, 20.
• Two natural stools (in the afternoon and evening), (eighth day), 6.
• A motion rather more abundant and looser than usual, and having more smell, 11 A.M. (second day), 27.
• A stool of moderate quantity, with urging looser, more smell than usual, and a soreness in the anus while passing it, 2 A.M. (third day); later, more natural, indicating a quicker and more perfect digestion, almost inodorous, remaining so, 27.
• Soft stool voided with difficulty; looser stool; smells more; sensation of looseness in the bowels, as if diarrhœa were about to set in, with very slight gripings, 5 P.M. (second day), 27.
• Thin stool (nineteenth day), 3.
• Stool thinner than usual, followed by continued urging, lasting three minutes, without further effect (after one hour), 1.
• Very pressing motion, with urgings, almost as abundant as usually after breakfast 1 P.M. (second day), 27. [280.]
• Natural stool after dinner, but dark (one hundred and first day), 16.
• After dinner, natural stool, perhaps somewhat less than usual (one hundred and tenth day), 16.
• The fæces lose by degrees their stercoral odor, but the peculiar odor of the Coca, is to be detected in them, 22.
• Constipation.
• Constipation is of so frequent occurrence that, from its prominent character in the disease of Coca chewers, it has been called Opilacion, 9.
• Stool delayed (first day), 7.
• Daily evacuation delayed for three hours, 12.
• Evacuations not so regular, drier than usual, partly in small lumps, and inodorous (nineteenth day), 27.
• Though the evacuation was soft enough and well former, there was difficulty in voiding it, 12.
• Expulsion, with more than usual difficulty, of small lumps of fæces (after Magnesia), .

URINARY ORGANS

• Urethra.
• Fine stitches in the female urethra before urinating; urine normal (third day); again in the evening (eighth day), 30.
• A desire to urinate frequently, with increased flow of urine, 28.
• Micturition.
• Rose at night to urinate, as he had to do constantly a long time ago, but not lately, and it ceased after the proving, 16.
• Rose to urinate at night often, during the fourth, fifteenth, nineteenth, twentieth, twenty-first, and twenty-third weeks, particularly after midnight, towards morning, or early in the morning, often in the fifteenth week, and the next following, 16.
• Quantity of urine decreased 47.60 centimetres, 14.
• Urine.
• Urine dark-brown (first evening), 7.
• Urine has an unbroken film all over its surface, iridescent in certain lights, with an appearance like fissures in it, mapping it out, and a flocculent, pale sediment floating at the bottom seen through the film (one hundred and twelfth day); 6 P.M., before dinner (one hundred and twenty-third day), 16. [300.]
• Urine acid, smelling like perspiration, 11.
• Urine passed at night formed a cloud in a short time, which by morning gathered into little bits like crumbs of bread, swimming at the bottom of the vessel, 27.
• Urine, with a yellowish-red sediment adhering to bottom of vessel, and a flocculent precipitate floating there, after standing all night (one hundred and sixty-eighth day), 16.
• Urine of the night has a pale orange-colored, somewhat flocculent, sediment, chiefly collected in one spot (eleventh day), is dark when passed (eightieth and eighty-first days), with a dusky-reddish sediment adhering to vessel, turbid (even when passed) after standing, with an oily-looking film on surface (eightieth, eighty-fourth, and ninety-eighth days); more after standing all night, less of the day urine, 16.
• Quantity of urea decreased 2.0101 grammes; of chloride of sodium 3.4167 grammes; of sulphuric acid .2948 gramme; of free acid .6945 gramme. Quantity of phosphoric acid increased .0090 gramme. Microscopically there was found in the urine an abundance of octahedral crystals of oxalate of lime, of all sizes, 14.

SEXUAL ORGANS

• Male.
• Weakness of the genital organs, commencing as an indefinite sick feeling, followed by "bilious troubles," with their thousand tormenting complaints, especially constipation, jaundice, and numerous symptoms of disturbances of the nervous system, 9a.
• It is looked upon by the natives as a sure aphrodisiac; in two cases there was an observed after effect on the genital functions, 22.
• During the night, seminal emission, with voluptuous dreams; sleep restless, broken, 21.
• Female.
• Menses delayed for two days; come on about noon; got very profuse during the night, with some pain in the lower part of the abdomen; not in a steady flow as usual, but in gushes, awakening from sound sleep (tenth day); after drinking the infusion morning and evening for a whole week, 30.

RESPIRATORY ORGANS

• Larynx and Trachea.
• Irritation in larynx during afternoon, exciting cough, while sitting quietly in the room; gradually ceasing after coughing from fifteen to twenty times, 40. [310.]
• Tickling and irritation to cough, in the trachea and larynx, at 2 P.M., 1.
• Frequent tickling in the larynx, causing a short dry cough, when smoking (fourth day), 4.
• Voice.
• Hoarseness of voice, first in the evening (eighty-eighth day); all day (eighty-ninth day); less 9 A.M. (ninetieth day); again in the evening (ninetieth and ninety-first days); and soon after rising, last in the morning (ninety-eighth day), 16.
• Hoarseness, with tickling in the upper part of the trachea, and some cough (tenth day), 30.
• Cough and Expectoration.
• A tickling cough would cause a tingling (one hundred and forty-fourth day), 16.
• Much dry cough, in the evening, in bed, as from catarrh of the air-passages, 1.
• Cough in the morning, with expectoration of tenacious thick whitish-yellow mucus, as in chronic catarrh; with dryness of the throat and mouth, and thirst, 1.
• Occasional slight cough, indoors (forty-second day); sometimes preceded by tickling at back of throat (forty-third day); with expectoration, which was swallowed, 11 P.M. (eighty-eighth and eighty-ninth days); during morning (ninetieth day), 16.
• Evening, in open air, rather cool wind, paroxysm of coughing; afterward, frequent cough, usually preceded by tickling at back of pharynx, sometimes followed by soreness there, and loosening of mucus, fluent coryza in right nostril; indoors very slight (ninety-fifth day); when walking in hot sun 4 P.M., short paroxysm of coughing (ninety-sixth day), 16.
• Expectoration, after rising, more abundant than usual, and starchlike, and more difficult to hawk up, 27. [320.]
• Expectoration of small lumps, like boiled starch, which he has had for some time, immediately after rising in the morning, (second day); decreases, and is almost gone (fourth day), 27.
• Respiration.
• Abominable breath, 32.
• No want of breath on climbing up hill, .

CHEST

• Great freedom in the chest and in the whole body; feels very fresh and vigorous, with desire to walk rapidly and a long distance, although it is very warm and sunny (first day), 6.
• Heaviness on the chest, obliging him to take a deep breath frequently; it is neither painful nor unpleasant on walking or ascending steps (second day), 6.
• Heaviness and dyspnœa in the chest, in the forenoon while walking; sometimes a distended painful sensation on the chest, though impeding the breathing very little (from chewing the leaves), 6. [330.]
• A peculiar heaviness in the chest and shortness of breath in the evening, while walking slowly (seventh day after 30 drops of the tincture), 6.
• A painful heaviness in the chest, a constant need to take a very deep breath, continuing while sitting still after walking, with sensation as if the lungs were too much distended (seventh day), 6.
• Dull pains just below clavicles, continuing all day (ninth day), 18.
• Unusual fulness of the chest, stomach and abdomen, in the afternoon (second day), 5.
• Shortly after 12 P.M., one-half teaspoonful, a sensation of compression in the chest, in the region of the short ribs (first day), 21.
• Oppression of the chest (after two hours and a half), 1.
• Oppression of the chest (after four hours), 7.
• Much oppression of the chest, shortness of breath, especially on ascending steps, 5 . [This prover formerly suffered from difficult breathing, especially on ascending steps.]
• Soreness in upper lobe of lungs (sixth day), continuing all day (eighth day), 18.
• Sides.
• Pain beneath the first and second false ribs of the left side while walking (second day), 6. [340.]
• Slight stitches in right chest, near the sternum, about the fourth rib (seventh day), 21.
• Transient stitches in the left lung, between the third and sixth ribs, aggravated by deep inspiration (after one hour and three-quarters), 1.
• Stitching pains under left clavicle, at 12 P.M.; same pains under right clavicle, 4 P.M. (fifth day), 18.

HEART AND PULSE

• Heart's Action.
• Palpitation of heart, 22.
• Violent palpitation of the heart (second day), 7.
• Nervous palpitation of the heart, he frequently had, but not lately (fourth day), 21.
• Pulse.
• After an infusion of the leaves, pulse became much accelerated, beats of the heart being nearly quadrupled, 22.
• Pulse remained weak and accelerated until night (first day), 1.
• Pulse slightly increased during the first three hours, 11.
• Pulse increased from 70 to 134, with this also, a peculiar noise in the ears, 22. [350.]
• After 18 drachms in one day, his pulse rose to 134, and while in the height of delirium, he expressed fully, in writing, his feelings in the presence of several attending colleagues, 22.
• Results quite similar to those observed after the use of Caffeine, viz. (after about ten minutes), a slower and smaller pulse, with increased arterial tension; as may be seen by the subjoined tracings (see Plate I, Figs. 1 to 9), 43.
• Normal pulse was 80; under Coca, it sunk to 72, in forty minutes; and to 68 in one hour and a half, 44.
• Normal pulse 76; after ten minutes, 64; after one hour, 60; during two hours, 68; all day, 72, 43.

NECK AND BACK

• Pillows felt hard to neck and head, at night, in bed, 12.
• When bending neck down forwards, pain at upper part of back of neck (one hundred and sixth day); bending backwards or forwards, pain in muscles of left side of back of neck, as if strained, 10 P.M. (one hundred and twenty-eight day), 16.
• In morning, during expiration, rather more forcible than usual, sudden rather sharp pain in right lumbar region, when standing (one hundred and thirty-eighth day), 16.

EXTREMITIES IN GENERAL

• Pain in the limbs, often relieved for a short time by the outbreak of boils, 9a.
• Aching of the limbs, for a short time relieved by the appearance of furunculi, 9.

SUPERIOR EXTREMITIES

• Arm.
• Occasional pain in left deltoid; sudden in right deltoid, on using it, as if it had been strained, 9 A.M. (twenty-third and thirty-sixth days). In morning, pain for a short time about insertion of deltoid, on moving right arm by that muscle (one hundred and sixty-first and one hundred and sixty-second days). On raising or lowering left arm, pain in deltoid, as if it had been strained, 10 P.M., and during night lying on right side (fourteenth, fifteenth, sixteenth, and seventeenth days); better (eighteenth, nineteenth, and twentieth, again twenty-sixth day). 4 to 5 P.M., pain in right arm, just about insertion of deltoid, felt on raising the arm or lowering it, after having raised it; 4 P.M. (one hundred and fifty-second day). In morning, on lowering the arms, often on holding the arms clasped above the head sudden pain in lower part of right deltoid, as if sprained; also, for a few minutes afterwards, on raising and lowering the arm, by means of that muscle (one hundred and sixty-fifth day), 16.
• Forearm. [360.]
• Pain in the muscles of the forearm and along the border of the radius, on moving or pressing upon it, as from a violent blow; this pain lasted the whole day and became a very violent feeling, as if the place must be red and blue, though nothing could be seen (twelfth day), 6.
• Great pain in bones of left forearm, as if broken, worse by raising or stretching out the arm, so that he was scarcely able to use it, or to take hold of anything with the left hand, for two days (tenth day), 27.
• Hand.
• On borders of hand lame pain; afterwards several of the symptoms, e. g ., the urinary symptoms, the waking on back, the emptiness of stomach, etc., continued to return at times (after one hundred and sixty-eight days), 16.
• Fingers.
• Painful lameness in the fourth and fifth fingers of the right hand the whole day, especially noticed on stretching out the fingers or grasping anything, without external painfulness (third day); the next day this lameness became more located in the abductor of the little finger, and consisted of severe pressure with painfulness deep in the flesh, as after a blow or great exertion, 6.
• On washing, a deadness of little finger of left hand, with sensation of great enlargement of the same; further, a sound as from a middle-toned ringing bell; both symptoms lasting but a short time (sixth day). Deadness of right little finger, on waking in the morning, passing off in a few minutes (nineteenth day). Again, on waking from siesta (seventeenth day), .

INFERIOR EXTREMITIES

• On one or two occasions, slight staggering to the left (one hundred and forty-sixth day), 16.
• A weak trembling sensation in legs, 28.
• Hip.
• A stitching pain on right hip, with weakness in walking (first day); stitches running towards the bowels (fourth day), 21.
• Thigh.
• Walking in open air, a sudden momentary pain in right buttock, almost preventing the movement for a moment, 5 P.M. (eighty-first day), 16.
• A dull severe pain in left leg, from hip-joint to knee, 28. [370.]
• Walking in open air, occasional stinging in muscles at back of left thigh, inner side, above knee-joint, 5 P.M. (eleventh day), 16.
• Knee.
• In about six hours, aching pain in anterior portion of right knee, shooting down tibia to foot, after getting warm in bed, lasting till he fell asleep (six hours after taking the drug), 25.
• Leg.
• Awaking last night, cramp in right calf, calf painful on pressure and when walking during the day (thirty-second day), again 4 P.M. (fifty-first day), or while lying on the back with leg extended, sudden in left calf; slightly when sitting with knees bent, evening (eighty-fifth day), and in morning on going down stairs, when stepping with left foot (eight-sixth day), 16.
• Left calf feels painful, as after a cramp, occasionally, on going down stairs or walking or putting the calf muscles in action (one hundred and fifth and one hundred and sixth days), 16.
• Ankle.
• 1.45 P.M., when lifting up right leg in the act of running gently, a sudden transient but painless feeling, as if the ankle-joint had given way or become loose (forty-first day), 16.
• 4 P.M., when running gently in open air, sudden momentary feeling of weakness in left ankle-joint, as if it had given way (one hundred and twenty-ninth day); near 4 P.M. (one hundred and thirtieth day), 16.
• Right ankle feels sprained and weak when standing on right foot, this morning and last night (seventeenth day), 15.
• Foot.
• After taking globules (4 P.M.), very much fatigued in the feet, for some hours, .

GENERALITIES

• Objective. [380.]
• Weight of body increased one-eighth of a pound, 14.
• Retarded metamorphosis, diminution and prevention of the natural loss of tissues which attends every bodily effort; it lessens the waste of tissues, 34.
• Power of muscles notably augmented, 12.
• Aptitude for work increased, 12.
• Active and vigorous the whole day (sixth day after 10 drops of the tincture, the previous night), 3.
• Great physical vigor and great endurance, in spite of slight nourishment and little sleep, 10.
• Cerebral functions stimulated; inclination for work, and especially for fatiguing bodily exertion; hurried and impatient movements; rapidity in writing. Could not stay in one place, must go out, and walk or run, 43.
• General excitement of the nervous system, very similar to that caused by a mixture of coffee and brandy, 43.
• Strongly excited imagination; increased desire for bodily exercise; hand trembles, can hardly write; trembling of legs, shiverings in back, and inability to keep still, 43.
• Such a state of nervous excitement that he did not repeat the experiment (substituting it for the usual Chinese tea), 9a. [390.]
• Unpleasant nervous excitement, so that he was unwilling to make a second proving, 9.
• Indolence (twelfth day), 3.
• Weakness, in the afternoon (nineteenth day), 3.
• The patient becomes weak and emaciated, 9a.
• When jaundice occurs indications generally follow showing the shattered condition of the nervous system; the patient complains of headache, and other like sufferings, gets weaker, can scarcely take any food, and quickly becomes emaciated. This state is often succeeded by a kind of leukemia; the bilious tint gives way to a leaden color; an incurable sleeplessness sets in, 9.
• Gait unsteady, tottering, with trembling lips, disconnected speech, dull apathetic mood, 10.
• Becoming old very early, with imbecility in old age, 10.
• Chewers finally die of general consumption, 9.
• Œdematous swelling, and afterwards ascites, 9a.
• Partial œdematous swellings arise and subsequently terminate in ascites, dropsy, death; also pain of the limbs, which are removed in a short time by the breaking out of boils, . [400.]

SKIN

• Objective.
• In persons with a thin skin and fair complexion, hæmorrhage will take place from the surface of the body, 9.
• Some dark spots like ecchymoses under the skin, not elevated or painful, the largest about the size of a pin's head, on the contiguous sides of the first phalanges of the ring and little finger of the right hand, not affected by any pressure or washing. To-day I have also noticed three very minute similar spots on palm of right hand, also two similar spots close together on the ulnar side of the palmar aspect of the first phalanx of the left little finger, near the base, also two very small similar spots on radial side of the second phalanx of the right little finger (sixty-fourth day); the largest red spots were on radial side of first phalanx of right little finger; spots on palm of right hand gone (sixty-eighth day); are on left hand, and some on right, removed by washing (sixty-ninth day); the last rubbed off to-day (seventieth day), 16.
• In the loose skin, between the left thigh and scrotum posteriorly, a small lump, slightly tender on pressure, and sometimes when walking; no external appearance (eighty-first day), less tender (eighty-fifth day), 16.
• Eruptions, Dry.
• After using for a number of days, on himself and others, there broke out a circumscribed erythema; on one an exanthema resembling herpes, around the eyelids, 22.
• A kind of nettlerash breaks out on several parts of the body or is limited to the lips, and occasion scabs, bleeding and insupportable pains, 9.
• Small pimples on the inner surface of the thigh; they itched very much during the night, so that he was obliged to scratch them until they bled (seventh to ninth days), 7.
• Eruptions, Pustular.
• On right cheek, close to alæ nasi, a swelling, scarcely painful, even to pressure; rather hard, slightly apparent to sight, resembling one he had on the perineum, freely movable with the integuments of the part (one hundred and thirteenth day); getting smaller next ten days, then when pressing it, a slight discharge of pus mixed with blood, from an external hole just below it, repeating afterwards at intervals; getting smaller, two weeks; three weeks, after, still to be seen; nearly gone in the fifth week, 16.
• During the expiration, after a deep inspiration, a kind of tingling in hands, usually in both, but not always in same place, particularly in palm of left hand; once in palm and back of right hand, and once it seemed to go down palm of right hand towards fingers; once in both hands, and only during the first expiration if deep inspirations were repeated; not influenced by the position of the hands; evening and morning, while feeling very warm; when getting cooler it disappeared, . [440.]

SLEEP AND DREAMS

• Sleepiness.
• Frequent yawning, 1.
• Frequent yawning, without weariness, the whole forenoon (after 40 drops, eighth day), 6.
• Frequent yawning and sleepiness while sitting (first day), 6.
• Repeated yawning after supper (one hundred and fifty-third day), 16.
• Transient sleepiness, followed by wakefulness, lasting till 4 A.M. (fifth day after 10 drops of the tincture), 13.
• Unusual sleepiness after twelve hours dispensary work, 27.
• Extreme sleepiness at 5.30 P.M., could scarcely keep the eyes open long enough to write a few words, relieved for an hour and a half after coffee (third day), 3.
• Inveterate sleepiness, 9a. [450.]
• Sleepy at 4 P.M. (third day), 3.
• Sleepy very early in the evening, was, however, unable to sleep, for in bed he became wide awake, with heat, violent throbbing of the temporal arteries until midnight (fourth night), 2.
• More sleepy than usual and tired at night (twenty-second day), 27.
• More sleepy than usual, nevertheless can do with but four hours sleep in the twenty-four without feeling overfatigued, 27.
• More sleepy than usual after dinner, and late at night, when reading or writing, 27.
• Great drowsiness, overslept about two hours beyond the usual time; after inhalations, 27.
• Much more drowsy, apt to doze when sitting, and reading, or studying the Materia Medica at night which is always a delightful occupation, keeping him awake generally till after 2 A.M. (twelfth day), 27.
• After dinner, at 1 P.M., slept, and felt very sleepy till about 4 P.M. (one hundred and second day), 16.
• Overpowered by sleep after dinner, for an hour (fourth day), 3.
• Very quiet sleep (first night), 6. [460.]
• Deep sound sleep from evening till 7 P.M. (fourth night), 3.
• Slept sounder and later than usual (eleventh day), 15.
• Slept longer and sounder than usual in morning (second day); sleep the same up to fifth day, 15.
• Slept later than usual in the morning (fifty-sixth, fifty-seventh, fifty-eighth, and sixty-second days), .

FEVER

• Chilliness.
• A slight lowering of the bodily temperature, 45.
• Chilliness (third night), 3.
• About 10 P.M., when sitting indoors with a window behind my back open, chilliness, and afterwards shivering; the shivering continued after the window was closed, and also in the open air, going off with rather quick motion in open air. (The weather felt cold to me, though I had on rather a thicker coat than usual; my companion felt rather cold, though others found the evening warm at that time), (ninety-eighth day), 16. [500.]
• Chilly (fifth day), 2.
• Felt very chilly all over, and inactive (second day), 25.
• Felt quite cold the whole day (seventh day), 3.
• Chilliness in the head (seventh day), 7.
• Heat.
• Fever in the afternoon, with great prostration, relieved by wine (the relief continued until evening), (fifth day), 3.
• After three drachms of infusion, a feverish condition, with increased heat of skin, 22.
• Occasional slight heat in right chest, about middle near sternum, indoors, 1 P.M., and afterwards (fifty-first day), 16.
• Flashes of heat up the back, and burning across abdomen in flashes, 28.
• Warm feeling in front of left thigh, at 1 P.M. (ninth day), 15.
• Sweat.
• Perspire freely and without exertion, 23. [510.]
• Profuse sweat in the evening (ninth day), 7.
• Extremely unpleasant perspiration, offensive breath, 10.

CONDITIONS

• Aggravation.
• ( Morning ), Fear; confusion of head; after rising dull headache; lachrymation, etc.; flow from nose; early, in bed, feeling in nostril; on waking, dryness of mouth; feeling in mouth; on waking, bitter taste; on rising, soreness at back of throat; tickling at back of throat; hawking of mucus; on waking, pain on swallowing; at 8 o'clock, flatus from bowels; during forcible expiration, when standing, pain in lumbar region; on waking, deadness of little finger.
• ( Forenoon ), Pulsation, etc., in ears; yawning.
• ( Afternoon ), About 5 or 6 o'clock, indoors, confusion of brain, etc.; headache , etc.; about 1 o'clock, indoors, slight headache; towards 4 o'clock, while reading, pains above eyes; bitter taste on tongue; fulness of chest, etc.; weakness; fever, etc.; at 10 o'clock, warm feeling in front of thigh.
• ( Evening ), Depressed, etc.; towards 9 o'clock, fulness, etc., in forehead; flames before eyes; hearing too acute; abdomen distended; heaviness of chest, etc.; loss of spleen; sweat.
• ( Night ), Itching of pimples on thigh; chilliness; at 10 o'clock, when sitting indoors, with window open behind back, chilliness.
• ( Walking in open air ), Vertigo; during rain, pain in temple, etc.; paroxysms of cough.
• ( Ascending steps ), Vertigo; blackness before eyes.
• ( Bending head forward ), Giddy feeling.
• ( Blowing nose ), Pain over side of head.
• ( After breakfast ), Nausea.
• ( Chocolate ), Colic.
• ( Coffee ), Eructations; colic.
• ( Coughing ), Pain in forehead.
• ( After dinner ), Eructations; sleepiness.
• ( Eating ), Spots before eyes; soreness in jaw.
• ( Elevating head and turning eyes up ), Frontal headache.
• ( Walking quickly in hot sun ), Pain in temples.
• ( Deep inspiration ), Stitches in lung.

SUPPLEMENT: COCA.

Symptom 364, in vol. iii, copied from Hering's Monograph, begins with "On washing;" in North. Amer. Journ. of Hom., New Series, vol. v, p. 179, first line, it is "On waking."

Authorities.

45 , Alex. Cochet, Journ. de Chim. Méd. (Amer. Journ. of Pharm., 1833-4), p. 58, effects of chewing, on the Indians of Peru; ( 46 to 50 , Berridge's Collections, Appendix to Brit. Journ. of Hom., general effects); 46 , Dr. Martius, from Gauger's Repert., 1842, p. 452 (Pharm. Journ., 1843, vol. ii, p. 660); 47 , Prof. Schlechtendal, from Encyclopædia of Med. Sci. and Archiv. der Pharm., 1853 (Pharm. Journ., vol. xiii, p. 224); 48 , Schroff, from Wien. Wechnbl, vol. xviii, and Schmidt, vol. cxvi, p. 297 (New Sydenham Soc. Pub., vol. xix, p. 453), experiments with Cocaine, its acetate and chloride, and an alcoholic extract of the leaves; 49 , Rossi, Roman Correspond, Sci. (Lancet, 1866 (2), p. 195); 50 , Practitioner, 1868, vol. i, p. 233, Review of Recherches Chim. et Phys. sur l'Erythroxylum Coca du Perou et la Cocaine, by Thomas Moreno y Mais, Paris, 1868; 51 to 55 , Edward Lippman, Thèse Étude sur la Coca du Perou, Strasbourg, 1868); 51 , effects of hot infusions of 1 to 15 grams to 60 of water; 52 , effects of 30 grams; 53 , extract of 2 grams; 54 , obs. of Rossier, effects of chewing 1 to 3 grams of the leaves; 55 , Mr. Reis, chewed the leaves; 56 , l'Union, No. 91 (New Sydenham Soc. Pub., vol. xix, 455), (Berridge), effects of leaves; 57 , Scrivener, Med. Times and Gaz., 107 (2), p. 407, effects, on chewers; 58 , Berridge, North. Amer. Journ. of Hom., New Series, vol. v, 1874, p. 165, Dr. David Wilson, inhaled the vapor while potentizing about 3.30 P.M.; 59 , E. B. Shuttleworth, Can. Pharm. Journ., Aug., 1877 (Pharm. Journ. and Trans., vol. viii, 1877, p. 221), effects on the Toronto Lacrosse Club.

MIND

• Its effect is to deaden sensation and produce even madness, 46.
• In large quantities the chewing of leaves induces a stage of intoxication, like that of Cannabis, 56.
• Animation and content, 57.
• When chewed in large quantities, the Coca causes a kind of intoxication and loss of sleep, 45.
• The head felt agreeably light, the ideas flowed with facility, and fantastic images followed each other in rapid succession; this was soon succeeded by extreme drowsiness, in resisting which there was great oppression of the head and confusion of thought. If he had given way to it the prover felt he would have passed into an agreeable dream life, like that produced by Cannabis. The effect of the drug varies according to the intensity of the effort made to resist it. As soon as the interference with consciousness ceases, and the relation between the mind and the external world is re-established, all the other functions return to their normal state, 48.

HEAD

• Heaviness of the head, 52.
• Always after chewing the leaves sleep was quiet, but the next morning there was frontal headache, which lasted a part of the day; at the same time the tongue became coated and the appetite impaired, 54.

EYE

• Eyes brilliant, 57. [520.]
• After large doses of the decoction, there is dilatation of the pupils, and physical mental calm, 54.

EAR

• In half an hour, distant ringing booms through head, repeated twice, once in evening, lasting a few seconds, 58.

NOSE

• About midnight, on going to bed, nose felt swollen and stuffed, like an incipient catarrh (first day), 58.

FACE

• Countenance more animated, 57.
• Paleness of lips, 57.
• Slight yellow tinge about angles of mouth, 57.

MOUTH

• Teeth stained bright yellow, 57.
• It increases the secretion of saliva, produces a sensation of warmth and fulness in the mouth and stomach, and stills hunger, 47.
• Diminished saliva, 54.

THROAT

• Some dryness of the throat, 54. [530.]
• Heat and dryness of the throat, 51.

STOMACH

• It enables the workmen to endure prolonged abstinence, 56.
• Men may live in robust health several days without food. Rossi, after taking a decoction of the leaves, felt neither hunger nor thirst for forty-eight hours, 49.
• They appear as if they had partaken of a rich repast, 57.
• An agreeable heat; a sensation of comfort in the epigastrium, somewhat like that produced by a glass of wine, radiating from the stomach over the whole body, 54.

RESPIRATORY ORGANS

• Enables them to ascend heights without dyspnœa, 56.

PULSE

• Pulse strong and frequent, 57.
• The pulse from the first gained in frequency and strength, while the breathing lost in frequency, but became deeper and fuller, 48.
• Pulse 59 (before taking); 63 (after five minutes); 56 (after fifteen minutes); 61 (after forty-five minutes), 53.

SUPERIOR EXTREMITIES

• A warm indistinct pain in left shoulder-joint, for a few minutes, at 12.30 P.M. (second day), 58.

GENERALITIES. [540.]

• Tetanic convulsions, hyperæsthesia, dilated pupils, and diminution of movements from loss of co-ordination, 50.
• Abuse of Coca causes signs of premature old age, unsteady step, yellow skin, want of brilliancy of eye, and general indifference or apathy, 57.
• General symptoms like those produced by a small quantity of alcohol, a slight disturbance of vision, slight increase in the frequency of the pulse; cold infusions produced the same effects, 51.
• Sustains the strength, 56.
• Desire for physical exertion, 57.
• Great feeling of comfort, 48.
• More agility in walking, 57.
• Increases the bodily activity, 47.
• The effects of small doses seems to be to resist fatigue, which I frequently noticed in long walks, 54.
• When provided with Coca, they (the Peruvians) can make rapid journeys, without suffering in their respiration, and can take unremitted exercise without being worn out by fatigue. They have been known when acting as guides, to travel twelve or fourteen leagues without stopping, and to perform this as rapidly as the best mounted horseman. This arises from the circumstance, that in these elevated regions, horses soon suffer in their wind, and hence gradually relax their speed; whilst, on the contrary, the Indians, by constantly using the Coca, do not thus suffer, and always keep the interior of their mouth in a moist state. The inhabitants of the country support all kinds of fatigue, for two or three days, without any other stimulant than the coca, 45. [550.]
• At the commencement of the match, about 1 drachm to 1 1/2 drachms of the leaves was served out to each man. This was chewed, in small portions, during the game, the saliva being swallowed. On first taking the leaves, a sensation of heat and dryness was produced in the throat. This was relieved by washing out the mouth, or gargling with water, after which the desire for water was no greater than usual. Soon after a sensible augmentation of force, and a general feeling of invigoration were realized, and continued to be felt throughout the game, so that fatigue was wholly, or in great part resisted. The pulse was observed to increase in frequency, perspiration was augmented, but no mental effect was noticed, save the exhilaration of spirits always attendant on the exercise of well-strung muscles and on the excitement of play, 59.
• Torpor, 52.
• General feebleness, 52.
• It produces, in large quantities, lassitude and drowsiness, .

SKIN

• While writing a long letter, about 8 or 9 P.M., felt in left groin and region of abdominal ring as if the skin were sore and smarting; it felt a little tender to touch. (Here he formerly had an extensive glandular suppuration several years ago, from cold and fever), (first day), 58.

SLEEP

• Slept remarkably well last night; dreaming that something was adhering to fauces at posterior entrance to nares which he was trying to detach; woke about 8 A.M., actually in the effort, and there really was mucus there to detach; still has the smarting soreness (second day), 58.

FEVER

• Increase of subjective warmth, 48.
• Coldness of the extremities, 47.
• General perspiration, 47. [560.]
• Cutaneous secretion rather diminished, 50.