Physostigma venenosum, Balfour.

Natural order , Leguminosæ.

Common name , Calabar bean.

Preparation , Triturations of the whole bean.

Authorities.

1 , Christison, Pharm. Journ., 1855, p. 474, proving on self, ate 1/8 of a bean in afternoon and 1/4 of a bean the next morning; 2 , Frazer, Edin. Med. Journ., 1863, proving on self, took 6 grains of powdered bean; 3 , same, effects of 8 grains; 4 , same, effects of 10 grains; 5 , same, effects of 10 minims of tincture; 6 , Robertson, Edin. Med. Journ., 1863, effects of chewing bean; 7 , Maclaren, from Fraser, effects of chewing and swallowing a small piece, in a woman; 8 , Wells, Med. Times and Gaz., 1863, effects of application of 1/10th of a minim (equalling 4/10th grain of bean) to lower lids of eyes, normal pupil a trifle more than a line; 8 a , same, effects of application to eyelid, in a woman, suffering from paralytic mydriasis, can read only No. 16 test type; 9 , Ogle, Br. Med. Journ., 1863, effects of application to eye; 10 , von Græfe, Deutsche Klin., 1863, experiemnts on the eyes of nine healthy persons; 11 , same, Archiv. f. Oph., 1863, experiment on a man destitute of an iris; 12 , David Young, Ed. Med. Journ., 10, 192, poisoning of a boy, aged three, by eating the bean; 13 , same, in a boy, aged six; 14 , Cameron and Edwards, Med. Times and Gaz., 1864, poisoning of a large number (60) of children, by eating the beans; they averaged 2 to 4 beans each; one boy ate 12 and recovered; 15 , same, in a woman; 16 and 17 , Harley, Brit. Med. Journ., 1863, two cases of poisoning; 18 , Lingen, Petersb. Med. Zeit., 1864, a young man ate a whole bean; 19 , Robertson, Ed. Med. Journ., 1863, effects on eye; 20 , Rev. W. C. Thompson, effects on natives in Calabar, Trans. Roy. Soc. Edin., 22, 305; 21 , Todd, Indiana Journ. of Med. (M. and S. Rep., 1873), effects of 25 drops of tincture, every fifteen or twenty minutes, till 200 drops were taken; 23 , Dr. H. L. Chase, Trans. Mass. Hom. Med. Soc., 2, proving with 1st trit., 1 grain, first and second days; 23 a , same, subsequent proving, 1st trit., took 2 to 4-grain doses, first, third, fourth, sixth, and seventh days; 24 , Dr. Charles Cullis, proving with one dose of 1st trit., ibid.; 25 , Mrs. S., aged thirty, took 1 grain of 1st trit., ibid.; 26 , Dr. C. Wesselhœft, proving with 3d trit. doses, morning, first day, morning and evening, third day, afternoon, fourth day; 26 a , same, second proving, 3d trit., morning and evening, first day, morning, second day; 26 b , same, 1st trit., night and morning, for three days; 27 , Mrs. P., aged forty-nine, with "irritable eyes, muscæ volitantes," etc., proving with 1st trit., daily, for three days; 28 , Miss H. C., aged forty-two, proving with 1st trit., first, second, fourth, fifth, and sixth days (prover menstruated only twice the past year); 29 , Mrs. N., aged forty, proving with 1st trit.; 30 , Dr. H. B. Clarke proving with 1st trit., daily, for three days; 31 , same, proving in a young man, with 1st trit. (symptoms not repeated after a subsequent dose); 32 , same, in a boy aged five, effects of 1 grain of 1st trit.; 33 , Dr. William P. Wesselhœft, proving in a lady, aged thirty-five, with one dose of 3d trit.; 34 , Dr. William E. Payne, proving with 3d trit., doses for three days; 34 a , same, subsequently took one dose (20 grains); 35 , same, in a woman, aged thirty-five effects of a dose of the 30th trit.; 36 , same, in a man, one dose; 36 a , same as last, second proving, one dose of 3d trit.; 37 , Dr. Robert C. Smedley, proving with 30th, repeated doses for eleven days, then 3d dil. twelfth to seventeenth day; 38 , Dr. S. Lilienthal, effects of one dose of 30th trit., Trans. Am. Inst. of Hom., 1874; 39 , Dr. H. C. Houghton, effects of one dose of 3d, ibid.; 40 , Miss S., aged twenty, took one dose of 3d trit., ibid.; 41 , "X.," a man, took 3d trit., and after several days took the tincture, ibid.; 42 , Dr. Berridge, a man took 5 or 6 grains of P., evening and morning, ibid.; 43 , Dr. S. Swan, Hahn. Month., 1874, 9, 266, one dose of 1 m. ( 44 to 68 , provings of Am. Inst. of Hom. Trans., 1874); 44 , R. W. Stone, took 1 grain of 1st dec. trit., repeated doses first and fourth days, 2d dec. trit. twelfth day, and 5 grains at one dose sixteenth day; 44 a , same, took solution of 2d trit., repeated doses; 45 , G. W. Flagg, one dose of 30th trit.; 45 a , same, second dose after eight days; 45 b , same, third dose after a week; 46 , C. E. Rowell, a dose of 30th trit. first day, repeated doses of 1st trit., afterward second to eighth days; 46 a , same, subsequent proving, 30th trit. (no result), then 3d trit. (no result), then 1st trit. (no result), then 1st dec. trit., repeated doses for five days; 46 b , same, three months later took a dose; 47 , D. J., from Rowell a large dose of 1st trit.; 48 , E. J., took 1st trit. for three days, and on seventh day; 49 , W. W. French, took 30th trit., one dose; 49 a , same, 30th trit., a dose first and second days; 50 , G. S. Farmer, took 30th trit. two days, and on eighth day; 51 , P. N. Crosby, took 30th trit., first, third, fifth, sixth, and eighth days; 52 , J. P. W., took 30th trit., three doses, symptoms after third dose; 53 , Th. Foote, took 30th trit., one dose; 54 , J. M. Dart, took 30th trit., one dose, subsequently repeated; 55 , L. L. Barnard, took 30th trit. (no symptoms), then 3d trit.; 56 , F. A. Gile, one dose of 30th trit.; 57 , J. W. R., one dose of 3d trit.; 58 , W. H. Titus, one dose of 3d trit., subsequently repeated with same results; 59 , A. McDonald, one dose of 30th trit.; 60 , W. H. William, effects of 30th; 61 , C. Wesselhœft, proving of Mrs. Nichols, repeated doses of 30th; 62 , C. S. Collins, 3d trit., repeated doses; 63 , A. L. Kennedy, took 3d trit.; 64 , L. T. Hayward, took 3d trit.; 65 , Dillingham, took 3d trit.; 66 , Alfred K. Hills, a woman took 30th dil.; 67 , Miss Griffith, took a dose of 30th; 68 , H. A. W., a woman, aged thirty-seven, took a dose of 30th; 69 , Sharp, Essays, 1874, p. 771, effects of 5 drops of tincture, rubbed over eye and temple; 69 a , same, effects of 1 drop as before; 69 b , same, 10 drops as before; 70 , Dr. Barbosa, Bull. Gén. de Thérap., vol. 88, p. 45 (from Lisbon, Marseilles Med.), a large number of observations on effect of extract applied to eye; 71 , Dr. Farrington's MSS., provings (furnished to this work), P. G. Souder, 30th dil., three times a day, for a week; 71 a , same, 3d trit., three times a day; 71 b , same, 30th dil., three times a day for nine days; 71 c , same, 30th dil. four times a day, for three days; 71 d , same, 3d trit., three times a day for twelve days.

MIND

Acted foolish; said it made him crazy (second day), 41.
Felt quite exhilarated during the morning; very gloomy towards noon (second day), 61.
Felt great anxiety about friends at home; could not get them out of my mind (third day), 58.
Feel very irritable (third day), 54.
Does not wish to speak to some of his friends, 65.
Mental faculties unimpaired, unless perhaps it might be that I felt no alarm where my friends saw some reason for it (after 12 grains), 5.
Uncommon mental activity (second day), 30.
Perfect impossibility to concentrate my mind or to translate a single line (fourth day); perfect disinclination to any mental work; laziness and apathy reign supreme (fifth day), 38.
Difficulty of thinking or doing mental work (second day), 42. [10.]
It was difficult to concentrate thought (fourth day), 23a.
Did not feel the usual flow of spirits, and was obliged to make an extra effort in speaking with people, 26b.
Her thoughts wandered, and she had difficulty in fixing her attention, 25.
Mind wanders from study (third day), 46.
Peculiar inability to express my thoughts clearly and intelligently, with the headache (twelfth day), 44.
My mind is disturbed; cannot concentrate it, at times, on any one thing; unsettles me for study, 32.
Could not put my mind on anything; could not recollect anything; a mental exhaustion not confusion, 53.
Nothing was right; too many things in the room; continually counting them, 58.

HEAD

Confusion and Vertigo.
In five minutes he felt as if he had drank a glass of liquor; the head was confused, there was vertigo, and the legs lost their strength; he staggered like a drunken man, and went to bed with his head swimming. He fell asleep, but woke repeatedly through the night with terrible thoughts; he feared he was becoming crazy, and that he might get up and do some mischief, 24.
Vertigo and slight nausea, at 4.30 P.M. (seventh day), 71b. [20.]
Giddiness, in some cases, 14.
Giddiness, 12 ; (after one hour), 36.
Giddiness, very disagreeable (after one hour); with a constrictive feeling of head (after seven hours and a half); giddiness has been a constant symptom (after thirteen hours and a half), 36a.
A slight degree of giddiness (after fifty minutes), 2.
A slight giddiness, which occurred in fifteen minutes, was ascribed to the force of the imagination, and I proceeded to take a warm shower-bath, which process, with the subsequent scrubbing, might take five or six minutes more; the giddiness was then very decided, and was attended with the peculiar indescribable torpidity over the whole frame which attends the action of Opium and Indian hemp in medicinal doses. I now swallowed the shaving water which I had just been using, by which the stomach was effectually emptied. Nevertheless, I presently became so giddy, weak, and faint that I was glad to lie down supine upon the bed. On getting up, after a tolerable dinner, I was so giddy as to be glad to betake myself to the sofa for the evening (after 12 grains), 1.
Dizziness (after ninety-five minutes), 3.
Dizziness in the head, at 3 A.M. (third day), 33.
Dizziness, and a sensation of wavering in the brain was felt in walking (after half an hour), 23.
In walking downstairs, great dizziness and dimness of vision. Progression and gait very unsteady; encountered the wall and handrail more than once on the way out, 4.
There was dizziness in walking, and it required an effort of the will to keep from staggering (third day), 23a. [30.]
Dizziness, with faintness and muscæ volitantes, on moving, at 1 P.M. (fourteenth day), 33.
At night a strange dizziness was perceptible; she held to the bedstead to keep from falling, and made an effort to shake off the feeling, 25.

EYE

Left eye was red and swollen (fourth day), 58.
Right eye first inflamed, then the left; sclerotic red, dry, and swollen; eyes feel best when closed, 58.
Burning of eyes, and bloodshot appearance of them, all the forenoon (eleventh day), 33.
His father stated that "his eyes were working," or as his mother said, "as if the nerves were upon him," 13. [160.]
(Eyes unusually free from black spots, in the morning), (second day), 27.
Eyes very dull and heavy, at 2 P.M. (fifth day), 71b.
Eyes heavy, 13.
Eyes sleepy-like, 12.
Great pressure on the eyes, with muscæ volitantes. The medicine affects the sight very much, producing these spectres constantly flitting before the sight; long snakes or worms, both dark and light; also waves before the eyes, giving objects a tremulous motion, as if it gave the same quality of involuntary motion to the optic nerve that it does to the motor nerves, and made the sight movable; also a slight sensation of double sight, as if the images of objects would be multiplied (seventeenth day), 33.
Continued drawing twisting sensation in the eyes (thirteenth day), 71d.*
Sharp shooting and drawing sensation in the right eye , at 1 P.M. (fifth day), 71b.
Drawing twisting sensation in the eyes, at 3 P.M . (fifth day), 71b.
Since 11 A.M., have had great drawing twisting sensation in the eyes, at 8 P.M. (tenth day), 71b.
Drawing sensation in the eyes , at 6 P.M. (third day), 71a.* [170.]
Eyes are sore, and give pain when moved from side to side , at 6 P.M. (second day), 45a.*
Eyes smart; lids feel sore (third day), 61.*
(Was asked by a physician if I do not suffer from diplopia, as the musc. int. seems not to do its work rightly, and the axis of the eyes differs in each; but my eyes only felt weak, with lachrymation, especially of left eye, from which I suffer when having my usual headaches ), (sixth day), .

EAR

Pressure on the tympanum of each ear, which is painful (second day), 31.
Uncomfortable sensation in right ear; felt inclined to bore in with the finger; picked the ear and removed some wax, after which slight pain (after one hour and a half); with eructation , a sudden pain running from the throat along the Eustachian tube to the middle, leaving a transient stabbing pain in the middle ear; the pain to the ear repeated; the uncomfortable sensation (desire to bore) occurred repeatedly for several successive evenings, 39.
While writing, felt pain in right ear (fourth day), 61.
Considerable sharp pain in right ear, with the stiffness of the neck (third day); only a little soreness remaining (fourth day), 66.
Sharp shooting pain in the right ear, at 6.45 P.M. (fourth day), 71c.
Shooting pain in the left ear, at 3 P.M. (fifth day), 71b.
Fulness in ears (third day), 50. [240.]
Sensation of crawling feeling in left ear (third day), 46a.
Ears feel as if stopped up (ninth day), 50.
Hearing.
The ear symptoms were as if every sound went through the ear; ears very sensitive to sound (fifth day), 46a.
Partial deafness in the right ear, at 9 P.M. (fifth day), 71c.
Since 11 A.M., have had partial deafness in the right ear, at 8 P.M. (tenth day), 71b.
Slight deafness in the right ear (fifth day), 71d.
In the evening, hammering in right ear, while external ear felt as though hot air were blowing on it (third day), 61.
Singing or turning, like escaping steam, after lying down at night, 65.
Buzzing and ringing in the right ear, at 7 P.M. (third day), 71c.

NOSE

A small boil appeared on the inside of the right nostril; it was very painful, the pain extending up to the eye and right side of the head; it broke on the fourth day, with but little discharge (after five days), 24. [250.]
Slight epistaxis, right side, in evening (fifth day); left side, with the headache, in the morning, and while at supper (sixth day), 37.
Nose and throat filled with mucus; have had a similar sensation within a week (second day), 45.
Fluent discharge of clear coryza (after two days), 71d.
Frequent sneezing (after one day), 71d.
Sneezing (sixth day), 33.
Twitchings in the nose, and involuntary expansion of the nostrils (sixteenth day), 33.
A sensation exactly as if the nose was going to bleed, and the peculiar taste which goes with it, at 2 and 8 P.M. (fifth day), 33.
Burning heat in the nose, and sensation as if it would bleed, at 4 P.M. (nineteenth day), 33.
Nasal passages feel as if a fresh cold were coming on; smarting and tingling in the nose, and several times sneezing (after fourteen hours), 34.
Sensation of contraction in the alæ nasi and upper lip, with frequent desire to rub them, which relieved for the time; this lasted about twenty minutes (third day), 23a. [260.]
An intolerable itching and tingling of the left nostril, in the morning, with moisture of the same nostril; return of the itching, in the afternoon, with dryness of same nostril; again, in the evening, with moisture (fourth day), 67.
Nose stuffed and hot, 65.

FACE

Face flushed and red, 65.
Paleness of the face, with the headache (second day), 26.
Countenance very pale (after 12 grains), 1.
Pale face, 13, 15.
Very pale, 14.
Looked tired, in the morning (second day), 42.
Pain and flushing of the face, on rising from a sitting position (fourth day), 58.
Neuralgic pain in the right side of the face (second day), 60. [270.]
Had a curious feeling in my face; felt better when my mouth was open; at times this feeling extended down into my neck; I cannot describe it, but it seems to be of a cramping nature, or in spasms; at the time when this was the worst, my left hand became quite numb, and it bothered me to hold on to anything; this I noticed most when I went to look at my watch (fourth day), 58.
Sensation of contraction of the whole left side of the face , with slight numbness (after one hour, second day), 23.*
Occasionally severe pain in the right side of the upper jaw, like toothache, although the teeth on that side have all been extracted, with difficulty in keeping the eye open (second day), 23.
Pain in the side of the jaw where there were teeth (first day), 23a.
Fierce pains in lower jaw, right side (second day), 34.

MOUTH

Teeth.
Teeth felt rough, which brushing did not remove, in the morning (second day), 58.
Quivering sensation in the teeth, as if they were resting on a sounding-board of a piano (nineteenth day), 33.
Tongue.
Tongue coated white, and having an oily feel, with a very bad taste in the mouth (fourth day), 58.
Tongue coated slightly, more heavily towards the root (second day), 46b.
Tongue feels rough to the touch (after half an hour, second day), 49a. [280.]
Tongue dry and rough and sore (fourth day), 61.
Dryness and smarting of the tip of the tongue and lips continued all day (first day); dryness and smarting of the tongue the same as yesterday (second day), 23.
A raw feeling of the tongue, very disagreeable in swallowing, 52.
Tongue felt as if scalded (after twenty minutes, fourth day); the scalding sensation was all on the left side (fifth day); continuance of scalding (sixth day); felt on right side (seventh day); the scalding of tongue still continued, although the surface felt well (eighth and ninth days), 23a.
The tongue became very sore on the left side, quite back to the root, and it was very hard to move it, as if it was stiff, lasting nearly a day (fourth day), 33.
Tongue felt sore on tip and rough, at 4 P.M. (third day), 61.
Smarting of end of tongue ; feels as if burnt by hot liquid, 65.
Numbness and tingling smarting of the tongue and lips, with a constant desire to moisten them (after fifteen minutes), 23a.
General Mouth.
Involuntary twitching of the mouth, also of the eyebrows , and beating or throbbing and twitching between the eyebrows, also numbness from between the eyes down through the nose, at 8 P.M. (sixth day), 33.
The roof of the mouth feels as if covered with patches of loose skin; has a yellowish copper-colored appearance; at 9 P.M. (fifth day), 71c.
Taste. [290.]

THROAT

Throat and nose filled with mucus; had a similar sensation within a week (second day), 43.
Collection of clear mucus in the throat, at 6 P.M. (third day), 71a.
Throat became very sore, with a feeling of a fishbone lodged in throat; swallowing of saliva very painful; at 9 P.M. (second day), 44.
This evening (9 P.M.) my throat is very sore; tonsils and soft palate inflamed, dark-red, with stinging pain (fifth day); throat not so much inflamed (sixth day); smarting of left tonsil (after a quarter of an hour); left tonsil slightly inflamed; radiating redness of tonsil (after half an hour, eighth day); back part of throat very sore this evening (ninth day), 46.
Throat very sore, especially when swallowing, at 8 P.M. (fourth day), 71a.
Back part of throat very sore, at 8 P.M. (tenth day), 48.
Sensation of soreness in the throat, at 2 P.M. (second day), with constricted feeling when swallowing (fourth day); throat quite sore, at 5 P.M. (fifth day), 71b.
Throat began to be sore on the right side; seemed to be a little spot not larger than a pea, which bothered me a great deal in swallowing (second day); still sore at right side (third day), 56.
Throat quite sore; burning-scraping raw feeling, with a constrictive feeling when swallowing; at 7 P.M. (first day); throat much improved (fifth day); slightly sore (thirteenth day), 71d. [310.]
Slight soreness of the throat, when swallowing (fourth, fifth, and eighth days), 71 ; (8 P.M., second day), 71c.
Slight soreness of the throat, worse when swallowing (second day), 71.
Throat full (third day), 61.
Had a feeling as if a ball were coming up to the throat, 7.
A painful constriction of throat; soreness felt all through the posterior portion of pharynx, with painful swallowing of saliva, at 7 P.M., throat became dry by 10 P.M. (fourth day). The pain and constriction of pharynx still continued, and examination showed small ulcers, with yellow centres, on right side of pharynx, behind tonsil; posterior nares also dark-red, at 4 P.M. (fifth day). Throat very sore; very difficult to swallow; surface studded with fine ulcers, especially on right side, where the pain is greatest, from 4 to 10 P.M. (eighth day). Uvula considerably elongated, and though I have discontinued medicine for two or three days, the throat symptoms continue, though less violent (tenth day), .

STOMACH

Appetite.
Appetite increased (fifth day), 67.
Hunger, but can find nothing to satisfy it; disposed to try one thing after another; food has a flat taste, 65.
No appetite (fourth and sixth days), 46.
Loss of appetite (sixth day), 67.
Appetite not very good for breakfast (second day); no appetite for breakfast (third day), 54.
Appetite not so good as usual, with occasional nausea (first day), 34.
At times I noticed that I did not care for eating; appetite previously good at any time, 52. [330.]
Less appetite since taking the medicine (seventeenth day), 33.
Bad appetite (second morning), 5.
Morbid appetite (fourth day), 71b.
Declined food (second day), 12, 13.
Disinclined for breakfast; no appetite (second day), 42.
Perfect disgust for food of every kind, during the whole proving, 58.
Disgust for food, for tobacco, and coffee, and especially for cold drinks (I am a great water-drinker), (third day). There is not so much disgust for food, still I do not relish my usual cup of café au lait , and the toast remains untouched; no appetite (fourth day). Ate some light breakfast from mere habit, but still no desire for food (fifth day). Ate a very light breakfast, with very little relish (sixth day), 38.
Thirst.
Began in ten minutes to have thirst, which increased till they begged for water, then the power of swallowing was lost, 20.
They suffered greatly from thirst, and drank readily large quantities of warm water, 14.
Very thirsty, in the afternoon (seventh day), 48. [340.]
Have had no thirst at all to-day; usually drink considerable with my meals; drank scarcely any to-day; somewhat thirsty this evening, which may be due to eating beans at tea (second day), 46b.
Great desire for cold water all the evening; the more I drink the more I want (second day), .

ABDOMEN

Hypochondria.
Darting pains in right hypochondrium (after two hours and a half), 36a.
Griping pains in right hypochondrium (after half an hour), 36a.
Sharp lancinating pains in left hypochondrium, left thigh, and left forefinger, passing off very soon, and immediately followed by a sharp pain in the region of the liver, passing upwards and towards the sternum, lasting but a few minutes, at 9.50 A.M. (second day), 54.
Woke up heavily (not unusual), with considerable stiff pain in region of liver, posteriorly (second morning), 42.
Considerable stiff pain in region of liver, posteriorly, in the morning, on waking; tender on slight pressure, and on first moving; went off after moving a little (second day); same pain in liver region returned, in the morning (third day), 42. [420.]
Pain in the region of the liver, at 10.25 A.M. (second day), 54.
Hard sore pain in splenic region, descending to inguinal region, across hypogastric region, quite severe and increased by motion; in the evening the pain was so severe it caused me to extend the legs (three hours after second dose, second day), 61.
Sore pain in spleen, for two hours (third day), 61.
Umbilicus and Sides.
About 6 P.M., felt soreness in the umbilicus, and a sensation as though corset had pinched it; on examination, about 8 P.M., found the part very much inflamed (blood-red), very sore, and could not bear the contact of the clothing (fourth day); the following morning, inflammation somewhat decreased, but part still sore; soreness and inflammation continued about four or five days, growing gradually less, 57.
Drawing pain in umbilical region (seventh day), 67.
Pain in the umbilical region (second day), 49.
Sharp pain in the umbilical region (fifth day), 67.
Severe pain in the umbilical region, 13.
Severe colicky pains in the left side of the abdomen (second day), 68.
At 4 A.M., he arose with a soreness, not a pain, in the left side of the abdomen, which was painful on pressure; at 8 A.M., the soreness continued; it was painful when moving about, and was aggravated by riding; this soreness covered a spot as large as the palm of the hand, and continued five days, 24. [430.]

RECTUM AND ANUS

Sphincter ani swollen and rigid; evacuation painful; rectum protruding, swollen, and very sensitive (third day); anus still very painful (fourth day); hard lumps, like piles, protruding and very painful (fifth day); piles worse, burning, and very sensitive; used Cosmoline with excellent effect, as it quickly allayed the burning (sixth day); piles better during the day; at night the burning pain was so great, could get no rest till Cosmoline was applied, when I soon fell asleep (seventh day); piles much worse; one large soft protuberance on the left side of anus, and two large hard lumps, that seem attached to the sphincter, on the right side; they are dark-blue and very painful (eighth day); piles very hard, protruding, and causing great pain, while sitting or walking; the suffering was so great I took Physometra, 50 m. F.; shortly after taking it the pain and soreness lessened, and I slept well (ninth day); found the pain all gone and the piles decreasing in size (tenth day); had entirely disappeared (eleventh and twelfth days), 43.
Soreness in the rectum and urethra, and suspect I have taken cold (third day), 45a.
Return of piles, which have not troubled him for three years, 65.
Tenesmus, at 4 P.M., continuing an hour, when there was an evacuation of a soft thin stool; the tenesmus was a feeling all the time as though he had been to stool (third day), 30.
Tenesmus after the stool (third day); before and after the stool (seventh day), 71b. [480.]
Tenesmus of rectum with the diarrhœa, 37.
Desire for stool, but was much constipated; fæces hard and not much in quantity (three hours after third dose); three hours later, a very loose diarrhœa (watery) with some flatus. Some five days since the proving has affected me, and yet inclined to looseness of bowels, 52.
Anus sore, inclined to protrude a little (as if from relaxed sphincter), 65.
Burning at the anus with the stools, 45.

STOOL

Diarrhœa.
Freely purged, 13.
Purging in a few cases, 14.
Short attacks of diarrhœa and vomiting (first day), 28.
Large diarrhœic stool, with burning at anus, at 8.45 A.M. (bowels had moved just previous to taking the drug, and am nearly always constipated), (second day), 54.
Diarrhœic stool, with burning at the anus, at 8.10 A.M. (third day), 54.
Stool very loose and weakening, 65. [490.]
Soft thin stool, followed by great exhaustion; color of stool quite natural (third day); stool light-colored and very soft, not thin or watery (eighth day); quite thin and light-colored, followed with tenesmus, in the morning; thin at 12 M.; stool soft, and some tenesmus, at 9 P.M. (ninth day); quite natural (tenth day), 50.
A very copious stool, at 11 A.M.; passage from bowels of a yellowish color and soft consistency, at 3.30 P.M.; usually have but one passage from bowels each day, sometimes go two days; evacuation of a foul smell, at 6.30 P.M.; stool at 10. 30 (second day); stool at 6.30 A.M. (third day). Since proving, have been having two or three stools a day, at irregular times, not large, yellowish, 46b.
From 5 A.M. to 9 A.M., had about eight to nine large watery stools; the first ones mixed with fecal matter, the later ones light-yellow, watery, gushing out in a stream, with faint feeling, and cold sweat on the forehead; griping pain usually before stool, but not much relieved by the stool; the continual calls of nature drove me up, although the stools were, by 10 A.M., not more than a tablespoonful, and odorless (third day). Several times (two or three) a desire for stool, but only a small quantity of water escaped, and once some very foul-smelling flatus (fourth day). A bilious stool at 10 A.M. (fifth day), 38.
Soft, large, brown stool, at 7 A.M.; small thin yellow stool, smelling sour, at 2 P.M.; a small watery one, mixed with undigested food, smelling very sour, at 7 P.M.; small watery, at 10 P.M. (second day). Thin watery, with tenesmus afterwards, at 4 P.M. (third day). No stool (fourth day). Voided a large stool, part of which was natural looking, remainder black, like tar, at 7 A.M. (fifth day). Voided a natural-looking stool mixed with black lumps, followed by a small discharge of mucus, at 6 P.M. (sixth day). Small, thin, lumpy, stool; tenesmus before and after stool, at 4.30 P.M. (seventh day). Small hard stool, covered with a jelly-like slime, at 7, and again at 7.30 A.M. (ninth day). Natural-looking stool, at 7 A.M. (tenth day), 71b.
Bowels, which had been somewhat costive, moved twice, in the morning; two soft stools after dinner, with tenesmus and dull pain in transverse and descending colon; last stool fetid and brownish; two stools in the evening, with similar pains and tenesmus during and after stool; stools soft, brownish, and fetid, slight tenesmus of bladder at the same time (fourth day). Two soft mushy stools after breakfast, with same kind of pains; same kind of stool and pain, and tenesmus of bladder, after dinner and supper (fifth day). Same kind of stool after breakfast, with tenesmus of rectum and bladder, during and after stool (sixth day). Constipation during the day I took none, and when I recommenced had four passages in one day, but not loose, .

URINARY ORGANS

Kidneys.
Lame bruised feeling in the region of the kidneys with the headache (third day), 54. [510.]
Bruised sore feeling in region of kidneys (second day), 67.
Bladder and Urethra.
Sensation of fulness of the bladder, as from retention of urine, at 3 P.M. (eighth day), 71b.
Sensation of distension of the bladder, at 3 P.M. (third day), 71b.
Slight tenesmus of the bladder, with the diarrhœa, 37.
Crampy feeling in fundus of bladder followed the pain in the stomach (second day), 46.
Soreness in the urethra and rectum, and suspect I have taken cold (third day), 45a.
Pain in the urethra just after micturating, 58.
Micturition and Urine.
Frequent micturition (after two days), 71d.
Frequent desire to urinate; goes to the chamber several times with the inclination, but passes no urine, 65.
Almost constant desire to urinate, with the dull pain in the back, passing large quantities of reddish urine (third day), 60. [520.]
Did not urinate for the last eight or ten hours, although frequent and copious micturition is rather the rule with me (third day); hardly any urine passed during the day (fourth day); micturition freer (fifth day); urination natural, though not so frequent as usual (sixth day), 38.
Upon rising, passed more than the usual amount of urine, of a clear, slightly yellow color (second morning), 46b.
Increased secretion of urine, with difficult retention of it, in the forenoon (second day), 67.
The quantity of urine passed is slightly increased (second day); increased and of a pale yellow color, all day (third day); urine increased in quantity, and contains mucus; number of passages of urine increased; yellow color of urine; the amount of urine passed is greater than the amount of fluid I drink (fourth day); urine scanty (seventh day); passed a large amount of yellowish-colored urine containing mucus (ninth day), 46.
The urine was greatly increased in quantity, 60.
Urine increased in quantity, and yellow in color (fourth day); increased in amount (ninth day), .

SEXUAL ORGANS

Male.
Frequent erections, with but slight sexual desire, in the forenoon (second day), 46.
Two emissions, without dreams or excitement, 65.
Female.
Pains in the womb, as if menses were coming on (sixth day), 33.
A great deal of leucorrhœa (ninth day), 33.
Leucorrhœa and much weakness, at 4 P.M. (eighth day), 33.
(At the time of taking Calabar bean, had been troubled with a bland, milk-white, stringy leucorrhœa for about two months, not at all profuse, but rather scanty; have not been troubled with it since taking the bean), 57. [540.]
My condition altogether very like that induced by profuse flooding after delivery (forty minutes after 12 grains), 1.

RESPIRATORY ORGANS

Bronchi.
Irritation of right bronchi, 65.
Cough.
Dry tickling cough, at 6 P.M. (old ailment), (sixth day), 67.
Cough, caused by tickling in the throat (after half an hour, eighth day), 46.
Slight constant inclination to cough, from filling the lungs, 65.
Slight cough; coughs till small white plug of mucus is thrown off, 65.
Respiration.
Oppressed breathing (third day), 60.
Labored respiration (first night), 43.*
Sighing respiration (after one hour), 36a.*
Yawning and sighing respiration (tenth day), 34.* [550.]
Respiration accompanied with a little difficulty, and with a slight degree of dyspnœa (after ninety minutes); requires an effort (after one hundred and ten minutes), 2.
In the morning his breath was offensive (third day), 32.
During the proving there was shortness of breath, and a sensation of collapse of the lungs, as if all the air was expelled at each expiration, causing long and deep inspirations and a sighing expiration, 43.
Dyspnœa, at 10 P.M. (second day), 71b.

CHEST

Cannot fill left lung, as it produces a dull pain in upper part, relieved by pressure, 65.
Stitching pain near the apex of the right lung, at 5 P.M. (fifth day), 71b.
Soreness around the body at the waist, at 6 P.M. (fourteenth day), 33.
The severest pain in the left side, and entirely unlike any pain in the lungs that I have had, 33.
Pain in right deltoid muscle, which kept me awake during forepart of night, which was relieved only by violent motion (pain, nervous, uneasy), 57.
A slight pain in right side in region of sixth and seventh ribs, at 7 P.M. (eighth day), 50. [560.]
Severe muscular pains beneath the clavicles, extending down the inner sides of both arms, at 3.45 P.M. (fifteenth day), 44.
Slight twitches across the pectoral muscles (after 12 grains), 1.
Awoke with stitches in left breast; unable to take a long breath; symptoms continued all day; pains were so uncomfortable that no more medicine was taken (fourth day); pain in left side all gone (fifth day), 62.

HEART AND PULSE

Heart.
Dull pain in region of heart, lasting nearly an hour (after three hours), 62.
Uneasiness and distress about the heart, mostly without violent palpitation, but with a fulness and pulsation over the body, so that I counted the pulse, 72, by the ear; this uneasiness is principally at night, causing restlessness, tossing from one side to the other, with dry heat all over, 43.
I took a cup of strong coffee, after which I speedily felt an indefinable change within me, and on examining the condition of the heart, I found it had become perfectly and permanently regular (five hours after 12 grains), 1.
Violent palpitation of the heart , with the nervous motions (fourteenth and fifteenth days), 23.*
Violent palpitation of the heart, with throbbing all over the body, at midnight (first day), 43.
Woke about 2 A.M., with a rapid tumultuous action of the heart as in high fever; but there was no unusual heat (fourth day), 43.
Happening to get upon the left side, my attention was, for the first time, directed to the tumultuous action of the heart, which compelled me to turn again on the back, to escape the strange sensation (after 12 grains), 1. [570.]
As the fresh bracing air strikes me , a choking sensation, with fluttering of the heart (suffered frequently from this nervous affection between the age of sixteen and twenty) overcame me, and oppressed me during the whole forenoon; I heard and felt the fluttering of my heart in the throat, with the sensation of faintness by motion, and some relief in a recumbent sitting position, not by lying down (Bromine 50

without relief); fluttering keeps steadily on, with attacks of vertigo, towards evening, especially when changing position; heart's action irregular, thus about its action, --- --- ---, v v v , one, two, intermission; one, two, three, intermission; one, two, three, four; the choking sensation in pit of the throat is steadily present; sometimes it seems to me as if I could hear every artery of my body heat; I took a dose of Sulphur 30 ; in about twenty minutes afterwards a severe aggravation set in; I had to lean forward to catch my breath; deep sighing relieved me; hot sweat stood on my forehead; my hands were cold and damp; this lasted about a quarter of an hour, when the spasmodic action of the cardiac ganglia gradually ceased and I had a comfortable evening (fifth day). Heart's action still irregular, and sometimes tumultuous; radial pulse weak, 75, every eight to ten minutes beat intermitting (sixth day), 38.

While sitting still, he felt a pulsation through the whole body, particularly in the chest; each beat of the heart was distinctly perceptible in the chest and temples (after thirteen hours, third day, and other times), 26.
The heart and pulse extremely feeble and tumultuously irregular (forty minutes after 12 grains), 1.
Could readily count my pulse in the carotids, and hear the two sounds of the heart as my head lay upon my pillow (second day), 58.
Pulse.
Pulse accelerated (fifth day), 37.
Acceleration of pulse (96), usually about 74 (tenth day), 34a.
Pulse of right side nearly double in strength that of the left (fifth day), 44.
Pulse 60, at night (first day); 74, in the morning (second day), 60.
Pulse 93 (second day), 58.
Full pulse, 72 (second day), 55. [580.]
Pulse 70 (before the proving); reduced to 65, at times, 52.
Pulse slow (after three hours and three-quarters, second day), 49a.
The pulse has been, through the whole time, from 66 to 69; when well about 70, 54.
No change in frequency of pulse till twenty minutes, when it began to diminish in frequency and strength; afterwards could not be counted, 4.
Pulse slow by several beats (fourth day), 49.
Pulse 50 to 60, with feeble impulse (sixth day), 31.
Pulse small and frequent, 18.
Extremely feeble pulse, 14.
Feeble pulse, 15.
Pulse feeble and slow, 12. [590.]
Pulse variable (after one hour), 36a.
Pulse variable, full, and strong (after one hour and a half), 36.
The pulse had been examined at different times within fifteen minutes and found to average 68 (before the experiment); 74 (after six minutes); 72 (after ten minutes); 72 (after thirty minutes); 76 (after fifteen minutes); 75 (after twenty minutes); 69 (after thirty-five minutes); 66 (after forty minutes); 68 (after forty-five minutes); 64 (after fifty minutes); 65, full and regular (after fifty-five minutes); 62, and rather feeble (after sixty minutes); 62 (after sixty-five minutes); 60, very small and wiry, but regular (after seventy minutes); 62 (after seventy-five minutes); 60, thready, and difficult to count (after eighty minutes); 60 (after eighty-five minutes); 58 (after ninety minutes); 59, very feeble, with occasional intermissions (after ninety-five minutes); 56 (after one hundred minutes); 56, thready and intermittent (after one hundred and five minutes); 58 (after one hundred and ten minutes); 60 (after two hours); 59 (after two hours, five minutes); 60, rather fuller (after two hours, ten minutes); 58 (after two hours, twenty minutes), .

NECK AND BACK

Neck.
Inclination to stretch out the neck, "to run the head out," from uneasy sensations in the back of the neck (ninth day), 33.
Stiffness of right side of neck; not able to move the head, with a feeling of drawing and tension, which lasted several days (sixth day), 67.
Stiffness of neck on left side, 63.
While taking usual morning cold bath, was suddenly seized with stiffness in right side of neck, which extended during the day to the right shoulder, and also to clavicle, which felt sore, and was swollen over sterno-mastoid muscle; there was much pain from every attempt to move, and was relieved from leaning head towards right side; this pain continued quite acute all day, extending towards evening through right lung also; at times the pain in neck and shoulder was so severe as to cause nausea; considerable sharp pain also in right ear (third day). Stiffness in neck and pain in ear almost entirely disappeared only a little soreness remained (fourth day). A little soreness still in muscles of neck (fifth day), 66. [600.]
Pain in back of neck, reaching to first dorsal vertebra (after two hours and a half, second day), 62.
In the afternoon, a peculiar pain across the back of the neck, I should say at the base of the brain, as if it were cutting off the body from the head; it went right through the neck, and seemed to go to the back part of throat, which was stiff and sore; a feeling of loss of power and sensation in the back of head, as if the head would fall over forward, and the natural supports of the head would no longer hold it back; this was followed by pains all down the back of the neck, especially in the most prominent bone there, and on each side of it, drawing whenever the head was turned (fifth day), 33.
Soreness and pains, as from rheumatism, in left side of neck (after four hours and a half), 36a.
Seemingly rheumatic pains in left side of neck and shoulder of same side (second day), 36.
Back.
Back very weak; am unable to stand erect (continued two days), (after three days), 60.
Pain in the back came on again, at 2 P.M. (sixteenth day), 33.
Dull pain in the back, with almost constant desire to urinate (third day), 60.
Dull pain and downward pressure in the back, accompanied by the appearance of the menses (after two weeks), 27.

EXTREMITIES

The limbs felt weary, as after great fatigue, with a constant desire to move (fourth day), 22a.
Heaviness and weakness of limbs (third day), 50.
A numb or tired feeling of limbs (fifth day), 37. [630.]
A certain pleasant feeling of slight numbness in the limbs, like that which precedes the sleep caused by Opium or Morphia, which I remarked when awake for a minute, once or twice during the night (after 6 grains), 1.
Bruised feelings in my joints (second day), 38.
Slight stiffness in the joints, at 9 P.M. (seventh day), 71d.
Pain in limbs (eleventh day), 33.
Slight pains in the limbs (seventh day), 28.
Darting pains in joints; more in the legs than arms, extending up into the body; pain in my knees, worse when I flex them (third day), 38.
Neuralgic stitches in muscles of knees and arms, 32.

SUPERIOR EXTREMITIES

Shoulder.
Sharp shooting pain in the left shoulder, at 7 A.M. (fourth day), 71c.
Rheumatic pain in left shoulder, at 8 P.M. (second day), 71.
Drawing rheumatic pains through the left shoulder (after six hours), 29.
Arm. [640.]
Nervous, uneasy pain in right arm (second day), 57.
Sharp pain, first in left arm, then in the right, involving the shoulders of either side, 35.
A momentary constrictive pain suddenly seized the left arm, extending around, just above the elbow (after ten hours and a half), 34.
The next day felt pains in right arm (as from hitting the nerve), tingling, extending from elbow down the ulnar surface and into the third finger, repeatedly for three days, 39.
Pains down the arms, with weakness of the same (sixteenth day), 33.
Tired feeling in arms, and difficulty in lifting them (fourteenth day), 33.
A dumbbell, previously used with ease, was found a great burden, and the arm was with difficulty extended with it (after twenty minutes), 3.
Numbness in the left arm (after two days), 71d.
Numbness in the left arm and down the ring finger, at 7 P.M. (sixth day), 33.
Numb feeling down the left arm (sixth day), 31. [650.]
Burning throbbing sensation in the left arm and hand, as if it had been out in the snow or cold, with the sensation felt on coming to the fire, also a nervous, tremulous, weak feeling in the arm, at 11 A.M. (sixth day), 71.
Elbow.
Sharp darting pain in the right elbow-joint, extending down the outside of the arm to the two middle fingers (third day), 23a.
Acute pain in left elbow, and darts of pain from thence to fourth and fifth fingers, same side (these pains seemed to begin in left side of neck and elbow, and thence extend to left leg, locating in left knee, and were constant for hours), (after seven hours and a half), 36a.
Forearm.
Deep pain in muscles of right forearm and wrist came on about 8 P.M., and with it a dull aching pain at times occurred (first day). Pain moving; gnawing in inner aspect of wrist, deeply situated; from wrist it ran up along ulnar side of forearm to elbow; had a desire to move the arm and work it out, which did not relieve (second day), .

INFERIOR EXTREMITIES

Pain in lower limbs, at 9 A.M. (tenth day), 33.
A feeling as if all the power were going out of my limbs (legs), and they would give way under me, and I could not walk across the room, as if the cause of the weakness came from the spot in the back between the hips, and took away all power below that spot from the limbs, at 6.30 P.M. (eighth day), 33.
Slight twinging pain in the lower limbs (fourth day); particularly sharp momentary twinges in the ankle (fifth day), 28. [670.]
Lower extremities felt unusually warm, 65.
A feeling of weakness, as though paralyzed, passed downward from the occiput through the back to the lower extremities; the feeling in the legs was like that known as being asleep (after fifteen minutes, second day); same feeling in legs, but the sensation less perceptible in the back (after fifteen minutes, third day), 30.
Slight difficulty in walking (after seventy-five minutes); great difficulty (after one hundred and ten minutes), 2.
Staggered and was scarcely able to walk, 12.
Staggering gait, 15.
Staggering on attempting to walk, 14.
Could neither stand nor walk, 13.
Hip.
Stiffness in the hip and knee-joints (after two days); continued stiffness of lower limbs (fifth day); slight stiffness (eighth and thirteenth days), 71d.
Slight stiffness in the left hip, at 7 P.M. (third day), 71c.
Slight stiffness of the left hip and right knee, at 9 P.M. (fifth day), 71c. [680.]
Slight stiffness in the left hip, at 2 P.M. (second day); at 9 A.M. (third day); still continues (fourth and eighth days), 71b.
Left hip and right knee quite stiff, at 6 P.M. (third day), 71a.
Stiffness in the hip and knee-joints (fourth to eighth day), 71.
Thigh.
Severe cramplike pain in the left popliteal space; walking was very painful; it lasted two hours, gradually passing off; during rest the pain ceased, but commenced again on motion; but by continued motion it was relieved (one hour after second dose, seventh day), 23a.
Pain in the left thigh, and in both knees, after walking only a few steps, about noon (fourteenth day), .

GENERALITIES

Only one case proved fatal, a boy of six years, who ate six of the beans and did not vomit; he lived about two hours, 14.
The appearances presented were as if the nervous system had received a great shock, amounting to complete collapse, in the worse cases, 14.
Looked sleepy, listless, and depressed, and begged to be put to bed, 13.
Collapse after the vomiting, 18. [710.]
Convulsions and twitchings (especially in the back); death in thirty minutes, 20.
Trembling of legs, as if I could not walk straight, at 7.30 A.M. Seized with violent trembling all over, in the street, at 9.30 A.M. Felt for an instant as if I should lose consciousness, and could hardly get home; riding in a car for twenty minutes did not relieve the sensations; these trembling spells came on in fits, and at the least thing that startles; at 10.30 A.M. trembling of hands, so that I could hardly sew; this spell lasted an hour, when the soreness at the pit of the stomach came on (seventeenth day), 33.
Almost instantly felt a shuddering and trembling run down through all the nerves of the body; the sensations appeared to begin in the head and run down through the pit of the stomach, where they were strongest of all, and through the womb and all the body. The chief sensation in the head was the one in the middle of the forehead, between the eyes, above and over, and in the left eye a pain, with muscæ volitantes, 33.
Very restless through the night (first night), 54.
Somewhat restless towards morning (first day), 54.
Very restless in bed, not feeling satisfied in any position, at 10 P.M. (fifth day), 51.
Quite restless through the night (seventh night), 51.
Very restless, moving from side to side, throwing the arms about the head, but no position seemed to afford relief (tenth day), 34a.
Restless (first, second, and third nights), 57.
A constant desire to change from side to side, 52. [720.]
Feeling of great debility (after six hours and a half, third day), 44a.
Great sense of fatigue (general), as from long-continued labor, with fulness in forehead, and tendency to ache, mostly right side, continuing through the afternoon (after five hours), 34.
Rather fatigued during the forenoon (second day), 38.

Arnica 30 , which afforded prompt and decided relief, 34a.

The chief action of this medicine seems to me to be in the nerves; all the other symptoms have been entirely accessory and secondary; and it seems to me, so far as I can judge, to have a very curious double action on the nervous system; the nerves in front of the body (which I believe are the ?? voluntary nerves, or ?? nerves of motion), it appears to excite to involuntary motion, causing tremblings, and going up and down in wavelike motion, all down through; but the nerves in the back of the body (the ?? passive nerves or nerves of ?? sensation), it seems to paralyze and numb, and during this numbing process it causes a good deal of pain, very similar to a pain in a tooth when its nerve is dying or being killed, 33.
The medicine seemed to act more on the left side than on the other, 33.
I think the medicine hinders voluntary motion as well as causes involuntary motion, 33.
Better in warm room, from not moving, 65.
Walking seemed to relieve the pains, but I had not strength to continue any length of time (second day), 58.
Worse from motion, better in the open air (after two hours and a half), 36a.
State very like the effects of an overdose of Aconite (after 12 grains), 1.
Symptoms wore off gradually in two or three days (after six days), 66.

SKIN. [800.]

Eruption upon the back about the size of fleabites; the same petechial eruption on the arms (fourth day), 56.
Fever blisters in and around left nostril (seventh day), 67.
Applied to the skin it benumbs, and causes a pricking all over the spot, 6.
Itching of the left palm (fourth day), 23a.

SLEEP

Sleepiness.
Yawning (second day), 58.
Continual yawning, with a drowsy feeling all day (second day), 60.
For three or four days I felt irrepressible drowsiness, especially from early morning till 2 P.M.; this continued for a week. The drowsiness was diminishing (after two weeks), 27.
In the worst cases there was great drowsiness, while others complained of giddiness, 14.
Became drowsy, and slept for two hours, but the mind was so active all the while that I was not conscious of having been asleep (two hours after 12 grains), 1.
Drowsy at 11.30 A.M.; lay down and slept in afternoon (which I am not accustomed to); dreamt my head was full, and as if brain was revolving upwards from frontal sinus to occiput, and that I was almost blind (fifth day); drowsy, at 9 A.M. (sixth day), 37. [810.]
Sleepy (second day), 41.
Irresistible desire to sleep; soporific sleep , extremely distressing, with the headache (second day); felt drowsiness and desire to sleep all the forenoon, even while driving; after dinner the drowsiness, instead of passing off by exercise, increased, and for two hours he slept soundly, without dreams, in an uncomfortable position; he could arouse himself only with great effort; the sleepiness continued for an hour, even while walking in clear, cool air and bright sunlight; slept well all night (this is never the case after having even a short nap in the afternoon), (third day). He awoke at 6 A.M., and felt bright for two hours, when he became sleepy again while driving, with dull pressure encircling the head; after a light dinner, sleepiness became irresistible, and he slept some time; went to bed early and slept well (third day); drowsiness all the day, until after two hours' work in the garden, causing profuse perspiration, which expelled the drowsiness in part (fourth day); felt it slightly (fifth day), 26.
Felt sleepiness while riding, for two mornings; after dinner he felt great drowsiness, which was very difficult to shake off; his desire for sleep was uncontrollable; he would fall asleep so quickly that he was surprised on waking up that he had slept; a few hours of hard exercise would remove the drowsiness; he slept just as well at night as if he had not slept in the afternoon, 26b.
Such sleepiness that the attempt to keep awake produced nausea, with the headache, 66.
Intense sleepiness, which I thought came from the medicine (sixth day), 33.

FEVER

Chilliness.
Very cold, 14.
Chills in paroxysms (second day), 33.
Felt chilly, in the evening (first day), 31.
The heat of the bed was agreeable, as I could not throw off the sensation of chilliness which followed me the whole day (third day), 38.
Chilly creeps passing up the back, with the slight nausea, at 2 P.M. (fifth day), 71b.
Chilly sensation in my back, soon commenced to yawn and have bad feelings, a sort of bruised feeling in my joints; every draft of air seemed to make me shudder; every time I moved the same bad feeling come upon me (second day), 58.
Chilly on the right side of the back, at noon (second day), 60.
My limbs become chilly, with a vague feeling of discomfort; but warmth to the feet relieved this, and a sinapism over the whole abdomen was peculiarly grateful when it began to act (after 12 grains), 1.
Feverish, with chilly creeps up the back (fourth day), 71a. [840.]
Hands are cold, then hot and red, 65.
Feel cold all the time (after nine hours and a quarter), 36.
Cold and clammy skin, 14.
Heat.
Slight chills and fever, with the violent frontal headache, at 8 P.M. (third day); with hot and dry skin, at 10 A.M.; symptoms constantly growing worse, at noon (fourth day), 71a.
Temperature about 100 (second day), 38.
Feverish, at 2 P.M. (third day), 71a.
Dry heat all over, with the uneasiness and distress about the heart, 43.
Much heat in head and face, with heavy headache and pain in eyes, at 2 P.M. (tenth day), 33.
Heat hot and throbbing in temples, at 2 P.M. (third day), 71a.
Forehead hot and feverish, at 2 P.M. (fifth day), 71b. [850.]
Face hot, flushed, and suffused, together with a feeling as if a change into a lower temperature would produce chill, continuing through the afternoon (after five hours), 34.
Sensation of heat in face and down the back, as when the sun shines directly upon you on a cold day, while lower extremities were rather chilly, in the evening (second day), .

CONDITIONS

Aggravation.
( Toward morning ), Very restless.
( Morning ), Early, symptoms, 71 ; exhilarated; headache, with epistaxis; constriction around top of head; 9 A.M., pain in forehead; before rising, dull headache in forehead; on awaking, dull frontal headache; early, lateral headache; eye symptoms, with burning of the balls; 7 A.M., on rising, darting pains in both eyes; mydriasis; itching of left nostril, with moisture; tired look; teeth felt rough; on waking, taste in mouth like creosote; bad taste; on waking, nausea; pain in region of liver; 4 A.M., on rising, soreness in left side of abdomen; uneasiness in bowels; 4 A.M., griping pain in bowels; 7.30 A.M., before stool, pain in abdomen; offensive breath; pain in left of sacrum; 7 A.M., shooting pain in left shoulder; 7.30 A.M., trembling of the hands; 8 A.M., confused feeling; early, till 2 P.M., drowsiness; while riding, drowsiness, sleepiness; early, sleep disturbed by lascivious dreams; on waking, perspiration over whole body.
( Forenoon ), 8 A.M., dull heavy feeling in head; 8 and 10 A.M., dull headache; 8 A.M., heavy headache; congestive headache; while walking, pain in head, with dizziness; 10.15 A.M., headache in left frontal region; 10 A.M., heavy frontal headache; 11 A.M., while in church, aching in temporal region; shooting pains through right side of head; 11 A.M. to 8 P.M., drawing-twisting sensation in eyes; eyes bloodshot and burning; 11 A.M. to 8 P.M., partial deafness; 9.30 A.M., pricking sensation in stomach; sharp pains in stomach; 10.30 A.M., soreness at pit of stomach; 9.50 A.M., pain in left hypochondrium, thigh, and forearm; 10.25 A.M., pain in region of liver; 10 A.M., griping pain in transverse colon; 8.10 A.M., diarrhœic stool, with burning at the anus; secretion of urine; with difficult retention; erections, without sexual desire; in fresh bracing air, choking sensation, with fluttering of the heart; 11 A.M., burning-throbbing sensation in left arm and hand; pain in left wrist; 11.30 A.M., numbed sensation in hands; 9 A.M., pain in lower limbs; weakness in right knee; gnawing sensation in left tibia; 9.30 A.M., trembling all over; 10.30 A.M., trembling of the hands; 9 and 11.30 A.M., drowsy; 10 A.M., dry, hot skin.
( Toward noon ), Gloomy.
( Noon ), Nausea in throat; chilly on right side of back; all symptoms.
( Afternoon ), 4.30 P.M., vertigo and nausea; 1 P.M., on moving, dizziness; till 10 P.M., pain in head; headache; 5 P.M., headache; 2 P.M., headache and pain in eyes; 1 P.M., pain in forehead; 4 P.M., on motion, exercise, or mental exertion frontal headache; pain over right eye; 3 P.M., aching pain over left eye; 2 P.M., headache over right eye; 4 to 10 P.M., headache, with qualmishness; 1 P.M., headache over left eye; 2 P.M., dull frontal headache; 5 and 8 P.M., weight over eyes; 4 P.M., pain through temples, with throbbing of the arteries of the side of the neck; numbness of the temples and crawling sensation over the head; 1 P.M., headache in temporal region, with sleepiness; 2 P.M., eyes dull and heavy; 3 P.M., drawing-twisting sensation in eyes; 4 P.M., twitching of upper lids; 3 P.M., shooting pain in left ear; 2 and 8 P.M., sensation as if nose were going to bleed; itching of left nostril; with dryness; 4 P.M., tongue sore on tip and rough; 6 P.M., collection of mucus in throat; 2 P.M., soreness in throat; 4 to 10 P.M., throat sore, studded with ulcers; 3 P.M., when swallowing, pain extending from throat to left ear; thirst; 4 P.M., eructations; 5 to 8 P.M., hiccough; 3 P.M., sense of emptiness and weakness in stomach; 6 P.M., soreness in the umbilicus; 3 P.M., looseness in bowels; pain in abdomen; 4.30 P.M., cutting pain in abdomen; 5.50 P.M., bowels feel uneasy; 6 P.M., pain in groin; 2 P.M., pain extending from left hip into groin; 3 P.M., sensation of fulness and distension of the bladder; urine high-colored and smelling strong; 4 P.M., leucorrhœa and weakness; 6 P.M., dry cough; 5 P.M., sticking pain in apex of right lung; 6 P.M., soreness around the body, at the waist; 3.45 P.M., pains beneath clavicle; pain at base of brain; 2 P.M., pain in back; 1 P.M., stiffness and pain down spine; while sitting, pain under right shoulder-blade; 6.30 P.M., pain in back, between hips; pain in left of sacrum, 5 P.M., numbness of left forearm, with pain; pain; pain in right wrist; 2 P.M., pain in right knuckles; 6.30 P.M., weakness of legs; 6 P.M., left hip and right knee stiff; when walking, stiffness in both rectifemoris muscles; 6.30 P.M., sensation as of a drawing of cords behind leg and knee; 2 and 6 P.M., gnawing sensation in left tibia; sense of fatigue; 4 P.M., weakness and leucorrhœa; 1 P.M., languid feeling; just before 6.30 P.M., sudden access of vigor; nervous motions through body, with palpitation of the heart; 3 P.M., sleepy; 2 P.M., chilly creepings up back, with nausea; feverish; heat in head; face hot and flushed.

Physostigma