Physostigma venenosum, Balfour.

Natural order , Leguminosæ.

Common name , Calabar bean.

Preparation , Triturations of the whole bean.

Authorities.

1 , Christison, Pharm. Journ., 1855, p. 474, proving on self, ate 1/8 of a bean in afternoon and 1/4 of a bean the next morning; 2 , Frazer, Edin. Med. Journ., 1863, proving on self, took 6 grains of powdered bean; 3 , same, effects of 8 grains; 4 , same, effects of 10 grains; 5 , same, effects of 10 minims of tincture; 6 , Robertson, Edin. Med. Journ., 1863, effects of chewing bean; 7 , Maclaren, from Fraser, effects of chewing and swallowing a small piece, in a woman; 8 , Wells, Med. Times and Gaz., 1863, effects of application of 1/10th of a minim (equalling 4/10th grain of bean) to lower lids of eyes, normal pupil a trifle more than a line; 8 a , same, effects of application to eyelid, in a woman, suffering from paralytic mydriasis, can read only No. 16 test type; 9 , Ogle, Br. Med. Journ., 1863, effects of application to eye; 10 , von Græfe, Deutsche Klin., 1863, experiemnts on the eyes of nine healthy persons; 11 , same, Archiv. f. Oph., 1863, experiment on a man destitute of an iris; 12 , David Young, Ed. Med. Journ., 10, 192, poisoning of a boy, aged three, by eating the bean; 13 , same, in a boy, aged six; 14 , Cameron and Edwards, Med. Times and Gaz., 1864, poisoning of a large number (60) of children, by eating the beans; they averaged 2 to 4 beans each; one boy ate 12 and recovered; 15 , same, in a woman; 16 and 17 , Harley, Brit. Med. Journ., 1863, two cases of poisoning; 18 , Lingen, Petersb. Med. Zeit., 1864, a young man ate a whole bean; 19 , Robertson, Ed. Med. Journ., 1863, effects on eye; 20 , Rev. W. C. Thompson, effects on natives in Calabar, Trans. Roy. Soc. Edin., 22, 305; 21 , Todd, Indiana Journ. of Med. (M. and S. Rep., 1873), effects of 25 drops of tincture, every fifteen or twenty minutes, till 200 drops were taken; 23 , Dr. H. L. Chase, Trans. Mass. Hom. Med. Soc., 2, proving with 1st trit., 1 grain, first and second days; 23 a , same, subsequent proving, 1st trit., took 2 to 4-grain doses, first, third, fourth, sixth, and seventh days; 24 , Dr. Charles Cullis, proving with one dose of 1st trit., ibid.; 25 , Mrs. S., aged thirty, took 1 grain of 1st trit., ibid.; 26 , Dr. C. Wesselhœft, proving with 3d trit. doses, morning, first day, morning and evening, third day, afternoon, fourth day; 26 a , same, second proving, 3d trit., morning and evening, first day, morning, second day; 26 b , same, 1st trit., night and morning, for three days; 27 , Mrs. P., aged forty-nine, with "irritable eyes, muscæ volitantes," etc., proving with 1st trit., daily, for three days; 28 , Miss H. C., aged forty-two, proving with 1st trit., first, second, fourth, fifth, and sixth days (prover menstruated only twice the past year); 29 , Mrs. N., aged forty, proving with 1st trit.; 30 , Dr. H. B. Clarke proving with 1st trit., daily, for three days; 31 , same, proving in a young man, with 1st trit. (symptoms not repeated after a subsequent dose); 32 , same, in a boy aged five, effects of 1 grain of 1st trit.; 33 , Dr. William P. Wesselhœft, proving in a lady, aged thirty-five, with one dose of 3d trit.; 34 , Dr. William E. Payne, proving with 3d trit., doses for three days; 34 a , same, subsequently took one dose (20 grains); 35 , same, in a woman, aged thirty-five effects of a dose of the 30th trit.; 36 , same, in a man, one dose; 36 a , same as last, second proving, one dose of 3d trit.; 37 , Dr. Robert C. Smedley, proving with 30th, repeated doses for eleven days, then 3d dil. twelfth to seventeenth day; 38 , Dr. S. Lilienthal, effects of one dose of 30th trit., Trans. Am. Inst. of Hom., 1874; 39 , Dr. H. C. Houghton, effects of one dose of 3d, ibid.; 40 , Miss S., aged twenty, took one dose of 3d trit., ibid.; 41 , "X.," a man, took 3d trit., and after several days took the tincture, ibid.; 42 , Dr. Berridge, a man took 5 or 6 grains of P., evening and morning, ibid.; 43 , Dr. S. Swan, Hahn. Month., 1874, 9, 266, one dose of 1 m. ( 44 to 68 , provings of Am. Inst. of Hom. Trans., 1874); 44 , R. W. Stone, took 1 grain of 1st dec. trit., repeated doses first and fourth days, 2d dec. trit. twelfth day, and 5 grains at one dose sixteenth day; 44 a , same, took solution of 2d trit., repeated doses; 45 , G. W. Flagg, one dose of 30th trit.; 45 a , same, second dose after eight days; 45 b , same, third dose after a week; 46 , C. E. Rowell, a dose of 30th trit. first day, repeated doses of 1st trit., afterward second to eighth days; 46 a , same, subsequent proving, 30th trit. (no result), then 3d trit. (no result), then 1st trit. (no result), then 1st dec. trit., repeated doses for five days; 46 b , same, three months later took a dose; 47 , D. J., from Rowell a large dose of 1st trit.; 48 , E. J., took 1st trit. for three days, and on seventh day; 49 , W. W. French, took 30th trit., one dose; 49 a , same, 30th trit., a dose first and second days; 50 , G. S. Farmer, took 30th trit. two days, and on eighth day; 51 , P. N. Crosby, took 30th trit., first, third, fifth, sixth, and eighth days; 52 , J. P. W., took 30th trit., three doses, symptoms after third dose; 53 , Th. Foote, took 30th trit., one dose; 54 , J. M. Dart, took 30th trit., one dose, subsequently repeated; 55 , L. L. Barnard, took 30th trit. (no symptoms), then 3d trit.; 56 , F. A. Gile, one dose of 30th trit.; 57 , J. W. R., one dose of 3d trit.; 58 , W. H. Titus, one dose of 3d trit., subsequently repeated with same results; 59 , A. McDonald, one dose of 30th trit.; 60 , W. H. William, effects of 30th; 61 , C. Wesselhœft, proving of Mrs. Nichols, repeated doses of 30th; 62 , C. S. Collins, 3d trit., repeated doses; 63 , A. L. Kennedy, took 3d trit.; 64 , L. T. Hayward, took 3d trit.; 65 , Dillingham, took 3d trit.; 66 , Alfred K. Hills, a woman took 30th dil.; 67 , Miss Griffith, took a dose of 30th; 68 , H. A. W., a woman, aged thirty-seven, took a dose of 30th; 69 , Sharp, Essays, 1874, p. 771, effects of 5 drops of tincture, rubbed over eye and temple; 69 a , same, effects of 1 drop as before; 69 b , same, 10 drops as before; 70 , Dr. Barbosa, Bull. Gén. de Thérap., vol. 88, p. 45 (from Lisbon, Marseilles Med.), a large number of observations on effect of extract applied to eye; 71 , Dr. Farrington's MSS., provings (furnished to this work), P. G. Souder, 30th dil., three times a day, for a week; 71 a , same, 3d trit., three times a day; 71 b , same, 30th dil., three times a day for nine days; 71 c , same, 30th dil. four times a day, for three days; 71 d , same, 3d trit., three times a day for twelve days.

MIND

Acted foolish; said it made him crazy (second day), 41.
Felt quite exhilarated during the morning; very gloomy towards noon (second day), 61.
Felt great anxiety about friends at home; could not get them out of my mind (third day), 58.
Feel very irritable (third day), 54.
Does not wish to speak to some of his friends, 65.
Mental faculties unimpaired, unless perhaps it might be that I felt no alarm where my friends saw some reason for it (after 12 grains), 5.
Uncommon mental activity (second day), 30.
Perfect impossibility to concentrate my mind or to translate a single line (fourth day); perfect disinclination to any mental work; laziness and apathy reign supreme (fifth day), 38.
Difficulty of thinking or doing mental work (second day), 42. [10.]
It was difficult to concentrate thought (fourth day), 23a.
Did not feel the usual flow of spirits, and was obliged to make an extra effort in speaking with people, 26b.
Her thoughts wandered, and she had difficulty in fixing her attention, 25.
Mind wanders from study (third day), 46.
Peculiar inability to express my thoughts clearly and intelligently, with the headache (twelfth day), 44.
My mind is disturbed; cannot concentrate it, at times, on any one thing; unsettles me for study, 32.
Could not put my mind on anything; could not recollect anything; a mental exhaustion not confusion, 53.
Nothing was right; too many things in the room; continually counting them, 58.

HEAD

Confusion and Vertigo.
In five minutes he felt as if he had drank a glass of liquor; the head was confused, there was vertigo, and the legs lost their strength; he staggered like a drunken man, and went to bed with his head swimming. He fell asleep, but woke repeatedly through the night with terrible thoughts; he feared he was becoming crazy, and that he might get up and do some mischief, 24.
Vertigo and slight nausea, at 4.30 P.M. (seventh day), 71b. [20.]
Giddiness, in some cases, 14.
Giddiness, 12 ; (after one hour), 36.
Giddiness, very disagreeable (after one hour); with a constrictive feeling of head (after seven hours and a half); giddiness has been a constant symptom (after thirteen hours and a half), 36a.
A slight degree of giddiness (after fifty minutes), 2.
A slight giddiness, which occurred in fifteen minutes, was ascribed to the force of the imagination, and I proceeded to take a warm shower-bath, which process, with the subsequent scrubbing, might take five or six minutes more; the giddiness was then very decided, and was attended with the peculiar indescribable torpidity over the whole frame which attends the action of Opium and Indian hemp in medicinal doses. I now swallowed the shaving water which I had just been using, by which the stomach was effectually emptied. Nevertheless, I presently became so giddy, weak, and faint that I was glad to lie down supine upon the bed. On getting up, after a tolerable dinner, I was so giddy as to be glad to betake myself to the sofa for the evening (after 12 grains), 1.
Dizziness (after ninety-five minutes), 3.
Dizziness in the head, at 3 A.M. (third day), 33.
Dizziness, and a sensation of wavering in the brain was felt in walking (after half an hour), 23.
In walking downstairs, great dizziness and dimness of vision. Progression and gait very unsteady; encountered the wall and handrail more than once on the way out, 4.
There was dizziness in walking, and it required an effort of the will to keep from staggering (third day), 23a. [30.]
Dizziness, with faintness and muscæ volitantes, on moving, at 1 P.M. (fourteenth day), 33.
At night a strange dizziness was perceptible; she held to the bedstead to keep from falling, and made an effort to shake off the feeling, 25.
In the evening, in church, when in passing people in the doorway, if they stepped in front of me, felt very dizzy (second day), 66.
Unable to continue reading, especially because of the dizziness (after seventy-five minutes), 2.
Dizziness (after sixty minutes); in a slight degree (second day), 2.
General Head.
Head drooping listlessly, 12.
Head feels as if it were falling forward; vertigo; stumbles on going up and downstairs (third day), 60.
Brain feels tired (fifth day), 37.
Brain felt confused, after waking from midday nap (fifth day), 37.
Sensation as if the brain were loose and rolling about in the skull (after one hour), 36. [40.]
Stupid feeling in the head (third day), 42.
Stupid feeling in the head (third day), 50.
Head feels stupefied, at 7 P.M. (eighth day), 50.
Head feels dull and heavy (tenth day), 50.
During the whole time of proving she felt heavy and dull in the head, 29.
Dull heavy feeling in the head, at 8 A.M. (sixth day), 71.
Heavy feeling in the head, and darting pains through the temporal regions, worse from motion (after one hour), 36a.
Head dull, heavy, and full (fifth day), 37.
Dull heavy feeling of head; headache through forehead, 65.
Feeling as if something heavy were pressing the brain out (sixth day), 67. [50.]
A dull, heavy, bruise-like pain in the whole brain, but rather more severe in the left temple, with a sensation of general fatigue; this continued throughout the day till evening, together with a general sensitiveness to cold or change of temperature (after four hours), 34a.
Dull pain, and a disagreeable confused feeling in the head, worse from motion (after ten hours and a half), 36.
Darting pains in the head (after six hours and a half), 36.
Deepseated pain in the head, all day, aggravated by making a heavy or misstep, as if the brain were bruised (second day), 34.
Awoke with aching pains in whole brain, worse on left side (second day), 55.
Pain in the top and forepart of my head; this increased until I had to lie down; much better when I sat up in bed; strong pressure also relieved (second day), 58.
Pain in head, more severe over left eye, commencing in the morning; in the afternoon growing worse, and gradually increasing till 10 P.M., then beginning to subside; at same time, head bathed in warm perspiration (seventh day), 51.
Cannot study for the pain in my head (third day); could not study (fourth day), 54.
Headache (second day), 41 ; (third day), 44a, 52.
A severe headache occurred after drinking freely of new milk, which generally agreed with him (fifth day), 26a. [60.]
(During the afternoon, a severe attack of my habitual headache set in (had a sunstroke about seven years ago, and since then the left frontal and temporal region is liable to severe pressing-boring pain, as if a coal of fire were imbedded there, and the heat radiating to all sides; the veins of the forehead are swollen and stand out prominently), steadily increasing towards evening), (second day); (old headache moderately on left side), (sixth day), 38.
Headache began about 5 o'clock, across top of forehead, increased till after going to bed and asleep, lying down, 40.
Constant headache, not severe, but more of a dull heaviness; confused feverish feeling, alternating from the forehead to the top of the head (eighth day), 71.
(While travelling, in the cars, had an attack of the customary headache, which lasted from noon till late at night; pain and throbbing in the forehead, worse on moving; irresistible desire to sleep; soporific sleep , extremely distressing; paleness of the face; the sleepiness he never had before; the face was pale, and the attack was unusually severe), (second day), 26.
Sudden attack of headache, with nausea and bitter rising, followed by dull pain under the sternum; it was increased by suddenly turning the head, bending forward, or throwing the shoulders forward. On auscultation, heart's action was found to be retarded, with diminished impulse; rate, 56; there were no abnormal sounds, but the radial pulse was very irregular and weak. He thinks the symptoms may have come from a strain he had about a month ago, in lifting a heavy weight, as he had a similar feeling at the time; he lifted moderately the same day he took the medicine, but was unaware of any strain at the time (third day), 31.
Dull stupid headache, from the top of the head down through the head, in the evening (sixth day), 71.
Dull headache, at 8 P.M. (second day), 71c.
Dull headache, at 10 A.M. (third day), 45.
(Have been suffering from a dull pressing headache for nearly six months; comparatively free from it in the morning, on rising, but increased by the least mental exertion, until at night, after retiring, it would become almost unbearable; accompanying the pain were sleeplessness and inability to stop thinking; in the course of an hour or two, the headache would pass away suddenly, with a sharp radiating flash of pain, sometimes starting from the occiput and passing forward, at other times passing from before backwards; this headache I found to disappear after taking this medicine ), 64.
Some headache (after eleven hours); arose with a dull headache, not persistent, at 8 A.M. (second day), 45b. [70.]
Headache at times severe, generally a dull solid feeling (third day), 68.
Awoke at about 3 A.M. with a severe pressing headache, confined to sinciput and over left eye (ninth day), 51.
Stupefying headache; dull pain through forehead, worse over the left eye (after one hour and a quarter); headache increased; continuous through the entire day until about 6 P.M. (third day), 51.
Arose at 8 A.M. with a heavy aching head, better after rising (second day), 45a.
Heavy headache and pain in eyes, with much heat in head and face, at 2 P.M. (tenth day), 33.
Tensive headache; brain and scalp feel tight (second day), 42.
Headache, with fulness and a sense of faintness (sixth day), 31.
Congestive headache, all the forenoon (twelfth day), 33.
Headache, of a burning aching character, at 7 P.M. (eighth day), 50.
Headache, in the morning, with epistaxis, left side (sixth day), 37. [80.]
Headache, in the evening (fifth day); in the morning (sixth day), 61.
Walking increases the headache, 58.
Troubled with headache for some weeks after, which was greatly relieved during mental application, and aggravated when walking in the open air, 68.
During the afternoon some headache, increasing towards evening; pain subsided by 10 P.M.; head feels strange and confused (eighth day), 51.
More or less headache or heavy feeling about the head, during the day (second day), 45.
Fulness of head, almost to faint feelings, at times, 52.
Dull pressure encircling the head, with the sleepiness (third day), 26.
Constricted feeling in the head, as if some tight bandage were tied around it (after two hours and a half), 36a.
After taking the medicine, in the morning, fasting, there was a feeling of constriction around the entire top of the head, as if a tight cap were being pressed down as far as the temples; at the same time there was a severe pressure along the sagittal suture, as if from fulness in the longitudinal sinus, and dull aching in each temple; similar effects appeared each night and morning, about fifteen minutes after taking the medicine, 26b.
A stimulus, as he called it, in the neck, in occiput, going through the whole head until it reached the eyes; this lasted an afternoon and evening, 41. [90.]
Constant desire to move the head from side to side (ninth day), 33.
Increase of head symptoms, with a little perspiration (after sixty-five minutes), 2.
Forehead.
Severe pressing pain in the forehead, as though something hard was bound tightly on it, accompanied by dizziness while walking; this lasted all the forenoon, gradually subsiding (fourth day), 23a.
Deepseated pain in the forehead, with desire to rub it (third day), 23a.
Heavy pain in frontal region, worse from motion (after one hour and a half), 36.
Darting and transient pains in frontal and temporal regions (after fifteen minutes); worse from motion (after half an hour), 36a.
Intolerable pain over both orbits (sixth day), 67.
Sharp pain in the supraorbital region, running off towards the nose (third day), 60.
A burning and aching pain in forehead, at 9 A.M., continuing during the day, and until retiring, at night (third day), 50.
An aching-burning pain in forehead, at 1 P.M.; frontal headache on eating, exercise, or mental exertion, at 4 P.M. (eighth day), 50. [100.]
Pain in the right frontal region (sixth day), 43.
Pain in the head, over the right eyebrow, extending to the temple (fourth day), 43.
Pain over right eye, all the evening, 65.
At 3 P.M., have had, since noon, a persistent, dull, aching pain, not very severe, and situated over left eye; the pain was from motion or pressure (second day), 45b.
Pain in head, over the right eye, dull and weary (after three hours and three-quarters, second day), 49a.
Woke up with severe headache in forehead (second day); headache light at 12 M. (third day). This headache was very severe, and never before experienced; could not put my mind on anything, could not recollect anything; a mental exhaustion, not confusion, 53.
Severe and sudden headache, over right eye, with pulsation felt in occiput, at 2 P.M. (fifteenth day), 44.
Severe headache, over the right eye, lasting two days (after ten days), 24.
Violent frontal headache, with slight chills and fever, at 8 P.M. (third day); hot and dry skin, at 10 A.M., at times extending to the vertex, in the afternoon (fourth day), 71a.
Headache in left frontal region, with sensation of heat in the abdomen, and slight nausea, at 10.15 A.M.; headache continues, but dull and heavy, at 11.15 A.M.; headache has become general over the whole head, with qualmishness and slight perspiration over the body, at 4 P.M.; headache continues, with qualmishness, at 10 P.M. (second day). Headache less, in the morning; has continued nearly all day, with lame bruised feeling in the region of kidneys (third day), 34. [110.]
Awoke with headache in left frontal region, which afterwards extends all over the head; the pain is of a dull heavy character; at 1 P.M. the headache still continues, but seems to increase in the left frontal region; at 10 P.M., still continues; can hardly sit up (second day). The headache is the worst I ever had; cannot study for the pain in my head; not so tormenting, at 10 P.M. (third day). Headache, dull, heavy; began in left frontal eminence; extended deep into brain; headache, when walking in the open air, lying down; could not study (fourth day), 54.
Heavy, dull, and oppressive frontal headache, with peculiar inability to express my thoughts clearly and intelligently, at 10 A.M. (twelfth day), 44.
Heavy headache over left eye and extending over whole forehead, but most severe over left eye, as from a blow, at 1 P.M. (second day), 45a.
Dull frontal headache, in the evening (second day), 71a.
Dull frontal headache, at 2 P.M. (second day), 71b.
Dull heavy headache in forehead, before rising, 65.
Woke next morning with a dull frontal headache; by noon the headache involved the whole cerebrum; great fulness of the bloodvessels of the brain, 68.
Wakened in the morning with dull, heavy frontal headache, over the eyes , which passed off on rising (third day), 57.
Some frontal headache (ninth day), 50.
Fulness in forehead and tendency to ache, with the sense of fatigue (after five hours); a dull heavy ache, more in right side (after thirteen hours), 34. [120.]
Constant weight over the eyes, at 5 P.M. (fifth day); at 8 P.M. (eighth day), 71b ; at 8 P.M. (second day), 71c.
Feeling of constriction around the forehead and temples, changing into oppressive pain over the left orbit, and extending to the forehead and temples; very troublesome in reading (after half an hour), 26.
Sensation as of a rush of blood to the frontal and temporal regions (after fifteen minutes), 36.
Temples.
Pressure in temples (seventeenth day), 33.
Pain through the temples, as from pressure of blood to the head, with throbbing of the arteries on the side of the neck, at 4 P.M. (twelfth day), 33.
Occasionally there was severe, sharp, darting pain in the right malar bone, and in the ramus of the jaw on the right side (fourth day), 23a.
Darting pains in the temporal regions, worse from motion (after eight hours), 36.
Numbness of the temples, and crawling sensation over the head, at 4 P.M. (sixteenth day), 33.
Severe pain in both mastoid processes (after ten minutes), 44a.
Pain in both temples; in right temple, shooting pain down to second bicuspid tooth (two hours after first dose, sixth day), 37. [130.]
Flashes of pain in the right temporal region (second day), 43.
Dull pain in both temples, with pressing outwards in the frontal region (second day), 60.
In church, had a dull aching in temporal and frontal regions, at 11 A.M.; in the evening, the sound of the organ caused the return of headache; slight headache until retiring, worse in frontal and temporal region (second day). Same headache, only more intense, with such sleepiness that the effort to keep awake produced nausea, at 1 P.M.; this headache did not abate until about 6 P.M. (fourth day). Headache still occasionally but very slight, and sleepiness, as before (fifth day). Worse in a warm room, especially after being in open air (sixth day), 66.
Skin of forehead and nose felt tense, making it difficult to close the eyes; this feeling continued for some fifteen or twenty minutes, in church, then a remission, then commenced again (second day), 66.
Headache in the temples (ninth day), 48.
Headache in the right temple, at first a heavy dull pain; afterwards it became pulsative, and occasionally darting and quivering, like the motions of electric fluid passing from cloud to cloud, or from the cloud to the earth (tenth day), 34a.
Throbbing of temporal and carotid arteries (second day), 68.
Vertex.
Expansive sensation in top of the head (after one hour), 55.
A pressing, from within outwards, in vertex and temples, which continued for five hours after taking the last dose, 26b.
Intense painful pressure in vertex and both temples; the pressure in vertex extending over to occiput; pain so severe as to obliged lying down (sixth day), 67. [140.]
Pressure (bearing down) on top of head (after seven hours and a half, second day), 62.
Dull weight along the vertex, mostly on the left lobe of the brain (third day), 26.
Parietals.
Spasms of pain, at intervals of five and ten minutes, sharp and lancinating, in region of right parietal eminence, lasting one or two minutes, leaving a sore bruised feeling; headache relieved, in evening, by close attention to a metaphysico-theological sermon, renewed by coming out into open air (second day), 68.
Shooting pains through the right side of the head, extending down into the back part of the neck, worse when rising up or when walking, at 11 A.M. (eighth day), 71b.
Sharp pains, first in left side of the head, then in the right side, 35.
An undefinable pain in the right side of the head, with a feeling as if it would increase; nevertheless it did not, but continued the same throughout the day (third day), 34.
On awakening, pain on right side of head and right side of neck, with the feeling as though I had slept too sound; feels sore and stiff, similar to what is called a stiff neck; cannot bear my pillow high; feel as though my head would be easier on a single pillow, 52.
Lateral headache, early in the morning, with fear of opening his eyes, because he feared it would increase the pain (second day), 47.
Noise affects me (child crying); caused lateral headache (third day), 46.
Lateral headache, which seems deep in the brain, nearly always relieved by eating (after four days); coming on while riding in a carriage (seventh day), 46. [150.]
Sharp headache on right side, transient (tenth day), 44.
Some headache; worse on right side (ninth day), 50.
Occiput and External.
Dull pain in left occiput, lasting ten minutes (five minutes, after second dose), 41.
Occipital headache, more of a tired sensation, in cerebellum (sixth day), 38.
Contracted feeling of the skin of the forehead, which extended to the eyelids, causing an effort to close or open them (second day), 68.
A burning spot in centre of forehead (third day), 50.

EYE

Left eye was red and swollen (fourth day), 58.
Right eye first inflamed, then the left; sclerotic red, dry, and swollen; eyes feel best when closed, 58.
Burning of eyes, and bloodshot appearance of them, all the forenoon (eleventh day), 33.
His father stated that "his eyes were working," or as his mother said, "as if the nerves were upon him," 13. [160.]
(Eyes unusually free from black spots, in the morning), (second day), 27.
Eyes very dull and heavy, at 2 P.M. (fifth day), 71b.
Eyes heavy, 13.
Eyes sleepy-like, 12.
Great pressure on the eyes, with muscæ volitantes. The medicine affects the sight very much, producing these spectres constantly flitting before the sight; long snakes or worms, both dark and light; also waves before the eyes, giving objects a tremulous motion, as if it gave the same quality of involuntary motion to the optic nerve that it does to the motor nerves, and made the sight movable; also a slight sensation of double sight, as if the images of objects would be multiplied (seventeenth day), 33.
Continued drawing twisting sensation in the eyes (thirteenth day), 71d.*
Sharp shooting and drawing sensation in the right eye , at 1 P.M. (fifth day), 71b.
Drawing twisting sensation in the eyes, at 3 P.M . (fifth day), 71b.
Since 11 A.M., have had great drawing twisting sensation in the eyes, at 8 P.M. (tenth day), 71b.
Drawing sensation in the eyes , at 6 P.M. (third day), 71a.* [170.]
Eyes are sore, and give pain when moved from side to side , at 6 P.M. (second day), 45a.*
Eyes smart; lids feel sore (third day), 61.*
(Was asked by a physician if I do not suffer from diplopia, as the musc. int. seems not to do its work rightly, and the axis of the eyes differs in each; but my eyes only felt weak, with lachrymation, especially of left eye, from which I suffer when having my usual headaches ), (sixth day), 38.
Slight aching pain in left eye (after five hours), 33.
Felt film over the eyes, and blur; objects mixed (after ten minutes); after which dull pain over the eyes, and between the eyes , lasting for one hour; sometimes have had similar feelings, but not often, 56.*
Pain in the left eye, with muscæ volitantes, 33.
Eyes feel weak (third day), 54.*
Eyes sensitive (eighth day), and feel weak (ninth day), 50.
If a very weak solution is used, so that the accommodation is not markedly affected, we find that on attempting to use binocular vision, as in reading, a disturbance exists, consisting of pain, blurring, and straining, so that one eye must be closed, which is relieved by a weak concave glass; it seems as though the ordinary will, impulse, caused too great an action of the accommodation, 10.
Had the symptoms in the eye all the morning, with much burning of the balls (sixth day), 33.
Orbit. [180.]
Aching pain in posterior part of orbit, extending back into the brain; worse on reading (aches so cannot read), causing nausea (second day), 55.
Lids and Lachrymal Apparatus.
Twitching of upper eyelids, at 4 P.M. (fifth day); of left most, which is very annoying (seventh and ninth days), 48.
When the accommodation becomes affected by Physostigma, twitchings (spasmodic) of the lids ensue, 19.
Sensation of contraction of the eyelids, with difficulty of opening them, and a suffusion of tears when wide open (after fifteen minutes); it required and effort to keep the left eyelid open; this lasted till night, with pain in right side of upper jaw (second day), 27.
Cannot bear to raise the lids (sixth day), 67.
If Physostigma is applied to the lids it produces immobility of them, 6.
Eyelids feel heavy (second and fourth days), 54.
Lids, which are usually heavy, were less heavy, and can look more steadily at an object; but lids grow heavier again later, 65.
At night, intense itching of the edges of the eyelids and inner canthus of the right eye (sixth day), 43.
Eyes suffused with tears (after seven hours and a half, second day), 62.
Ball. [190.]
Pain in the eyeballs (third day), 41.*
Severe pains in the right eyeball, darting from within outward; relief from pressing on the eyes; the pain continued at intervals, from 6 1/2 to 10 P.M., when it seemed to shift to the supraorbital ridge, and continued till about 12 (after eleven hours and a half). As soon as I got up, at 7 A.M., experienced severe darting pains in both eyes; pain darting outwards; experienced no pain after breakfast; as soon as I sat down to study, at 7 P.M., had the same darting pains in the left eye and superciliary ridge; same character of pain, and relieved by pressure and moving about; pain gradually diminished until 11 P.M. (second day), 59.
Pain, with sharp stitches, in the ball of right eye, and in the frontal bone, with a distinct pain running obliquely into the temporal bone, in the evening (first day). Pain deep, in over top of ball; ran up from inner canthus to the right frontal eminence, then down obliquely outward into temple; dull miserable pain; same in eye and forehead returned, not as severe, but more general over the forehead, relieved by motion out of doors (second day), 57.
A drawn, twisted sensation in the eyeballs, at 8 P.M. (second day); especially in the right, at 7 P.M. (third day), 71c.
Towards the end of the myotic action there is experienced a painful tension, partly in the equator of the ball, partly in the ciliary region, 10.
Great fulness of the eyeballs, as if they were too large, with a sensation as if the lids were too tight on closing them (first night), 43.
Swollen sensation, with burning in the eyeballs (third day), 43.
Nervous achings in the whole ball, which extended along the supraorbital nerves, and over half the head, 10.
The circulation in the fundus of the globe is not affected, 10.
Pupil.
Decided dilatation of the pupil, very soon, 69a. [200.]
Pupils dilated (third day), 50.
After the myosis had passed off there is usually mydriasis of a slight degree for several days, especially during the morning hours; this seems to depend upon a kind of fatigue of the sphincter, which passes off during the day under the reflex stimulus of light, 10.
A very slight dilatation of the pupil was perceived, 69.
The myotic effects of the extract began to be noticed after fifteen to thirty minutes; the maximum contraction was obtained in from thirty to forty minutes; the myosis continued stationary from twenty minutes to three hours; the action of the drug was limited to the eye to which it was applied, 70.
On carefully watching the progress of the myosis (contraction of the pupil), the iris is seen to contract convulsively with little jerks or twitches; they are very small and rapid jerks, and would easily escape observation. While the iris was under the influence of Physostigma in all stages it was sensitive to light, that is, it would contract still more from a sudden strong light, even when the myosis had reached a high grade; this seems to show that the sensibility of the retina remains unaffected. The myosis lasts from two to four days, 10.
Pupils contracted (fourth, fifth, and sixth days); very much contracted (eighth day), 46.
Pupil very much contracted (after one hour), 69b.
Pupils contracted (second day), 42 ; (second morning), 47 ; (fourth and eighth days), 48.
In about two-thirds of the cases the pupils were contracted, and there was double vision, 14.
Not only was the pupil of the healthy eye rapidly contracted, but even the paralyzed pupil, which, before the application, measured three and a half lines, was contracted to two-thirds of a line (the size of a pin's head), within half an hour after the instillation of the extract. The maximum of contraction of the pupil was the same in each eye, but the left regained its original size sooner; it also always remained active under the influence of light, whereas the right was quite immovable. The sight of the right eye also rapidly improved, for within a quarter of an hour of the application she could read with it the very finest print, and this whilst its pupil was two and one-third lines in diameter. The effect upon the ciliary muscle was more marked in the left than in the right eye, for in the former the near point was approximated to three inches, the far point to five and a half inches; in the right eye the near point was never brought closer than eight inches, nor the far point nearer than eleven inches. Stronger concave glasses were consequently required for distant objects by the left than by the right eye. The effect upon the accommodation also ceased much sooner in the right than in the left eye, for in the former the myopia had disappeared five hours after the application, whereas six days afterwards the sight of the left eye for distant objects was still improved by a concave glass of thirty-six inches focus, 8a. [210.]
In a woman aged twenty-four, the sight of the right eye was so far impaired that she could only distinguish light from darkness, that pupil being very sluggish under the action of light, and much larger than its fellow. I applied a drop of the weakest solution between the lids of the right eye; after half an hour the pupil had become so contracted that it was only about half the size of the other one. In an experiment on another woman, the pupil of the eye to which the solution was applied was contracted one-half after fifteen minutes. Third experiment: a drop of the weak solution was applied between lids of right eye; no visible change in the left pupil was perceptible (after eight minutes); it had become slightly contracted (after twenty-three minutes); contracted to half the size of its fellow (after twenty-six minutes); it was less than half as large as its fellow (after twenty-eight minutes); this pupil was only about equal to a pin's head in size, the pupil of the other eye having become larger than it had previously been (after thirty-three minutes).
Fourth experiment; I applied a drop of the weakest solution between the lids of the right eye; no visible change (after eight minutes); pupil contracted to the side of a pin's head (after twenty minutes); very much contracted, but not to so great a degree as before (after nine hours); still contracted, but almost as large as the other pupil (after twenty-one hours). The woman first mentioned had the stronger aqueous solution applied between the lids of the right eye; the pupil was reduced to the size of a pin's head (after twenty-seven minutes). A woman of middle age had applied to left eye a drop of the weaker solution, now some days old; no change (after sixteen minutes); a drop of the stronger solution more recently made was applied; in four minutes more the pupil was slightly contracted, and in twenty minutes still later very much so, 9.
Pupils slightly contracted, 12.
Accommodation.
Decidedly tight feeling, referable pretty accurately to the ciliary region of that eye, as if something were creeping about in it (after five minutes); this continued with occasional rather sharp pains in the ciliary region (after ten minutes); an attempt to read with both eyes instantly increased this pain, and the type was confused, as if by a disturbance of the power of accommodation. The near point of the left eye (Jæger, No. 1) was at six inches and three-quarters, that of the right eye being fifteen inches, thus indicating a spasm of accommodation in the left, and a diminished power in the right eye; with this change, the effort to look at the type or optometer with either eye, or with both, much aggravated the sense of distress in the left eye; the type looked smaller with the right eye than with the left; the far point seemed the same as before in both eyes (after thirteen minutes). I could see Jæger 17 at fifteen feet, but with the left eye with a remarkable oscillation in the distinctness, so that the type came and went, at one instant quite clear, then indistinct, which coincided with the sensations present in the ciliary region, as if the ciliary muscle was undergoing irregular contractions; the left pupil was now observed to have become rather suddenly contracted to the size of a large pin's head (after twenty minutes); and to avoid repetition, I may state that this contraction continued to the full amount for eighteen hours, then gradually relaxed during about three days, after which it was like its fellow; as it gradually dilated, it also resumed gradually its mobility under light, whether falling on its own or the opposite retina, or on both; with the sudden contraction of the pupil came also a sudden twilight gloom, as of an eclipse of the sun, much more marked when the left eye only was open; but this gloom soon lessened, owing, probably, to the retina, by continuance, becoming accustomed to the quantity of light admitted, and on the next day it was hardly noticeable. The pupil being extremely small, we noted astigmatism; the vertical bars of a window were seen clear and sharp at from six to ten feet, the horizontal bars within the same range having thin edges, slightly hazy, but rendered clear by a concave cylindrical glass of fourteen inches focus suitably placed; distant objects seen by the left eye through a concave spherical glass of fifty inches focus were very decidedly diminished in size (after twenty-five minutes). The near point by No. 1 Jæger was for the left eye at six and a half inches, for the right eye only at ten and a half inches, not nearer or farther off, and even at this distance indistinct, whereas with the left eye the letters were crisp and clear; to this better sight of the left eye two causes contributed the larger size of the retinal image, from the greater nearness of the type to the eye, and the smallness of the pupillary aperture; with the left eye the near point for vertical lines was at eight and a half inches, for horizontal lines at six and a half inches; with the right eye the near point for vertical lines was at eleven and a half inches, for horizontal lines at seven and a half inches (after thirty hours). The strained feeling of the eye was less after half an hour, but did not quite cease until the next morning; the attempt to read continued painful all the evening and even next day both eyes were somewhat uneasy in sustained vision of near objects with both eyes or either of them. Both eyes alike as to accommodation, and in both eye near point for vertical and horizontal lines was one inch nearer the eye than natural, viz., for horizontal lines near point seven inches, vertical lines near point nine inches; and at twenty-four feet each eye could read No. 18 of Jæger, only the letters were more sharply defined with the left, and looked rather smaller. By way of comparison I accurately examined the accommodation for horizontal and vertical lines with each eye, and found both eyes alike; the near point for horizontal lines being nine inches, for vertical lines ten inches for each, one inch more remote from the eye than after eighteen hours from the instillation of the solution of the bean (tenth day), 8.
The action on accommodation consists in the approximation of the far point (myopia), and also of the near point; this contraction does not usually progress steadily, but by spasms or jerks (just as the pupil contracts); the far point is approximated sooner than the near point, 10.
Daturin paralyzes accommodation and dilates the pupil like Atropine, but Physostigma introduced after Daturin restores the accommodation and produces strong myopia, while the pupil is still widely dilated, 19.
The accommodation recovers before the pupil, 109.
The phenomena of the accommodation lasts much shorter than does the myosis. The approximation of the near point lasts longer than that of the far point, 10.
Vision.
Can see farther than usual (is naturally myopic), (second day), 42.
Double vision, 15.
Vision 1/2, with the use of a positive cylindrical glass 1/24 (hyperopic astigmatismus); range of accommodation 1/5, 5 (before the experiment); myopia 1/30; near point remains at 5 1/2 inches, though accommodation is reduced 1/6, 3/4 (after nine minutes). From this time the myopia gradually increases, and soon a slight nearing of the near point begins, with no trace of pain. Myopia 1/10; near point 5 inches; accommodation only 1/10; visual acuteness diminished to 2/3 (after twenty-two minutes). [This diminution of visual acuteness in this case is not dependent on contracted pupil, as had been supposed in other cases. -T. F. A.]
Myopia 1/7, 1/2; near point, 4 3/4 inches; accommodation only 1/13; vision very indistinct at a distance, on account of large dispersion circles (after thirty-two minutes). Accommodation same; myopia begins to diminish (after forty-four minutes). Accommodation 1/9; myopia 1/10; near point the same (after forty-seven minutes). Accommodation 1/7; myopia 1/16; near point a little farther (after fifty-two minutes). Accommodation 1/6; myopia 1/24; near point 5 inches (after one hour and fourteen minutes). Accommodation 1/5, 1/2 (nearly normal); near point 5 inches; myopia only 1/50 (after one hour and fifty-two minutes). The action on the ciliary muscle seems entirely independent of the presence of the iris. Slight biting in the conjunctiva, which passed off in a minute, 11. [220.]
When Atropine was first dropped into the eye (using a solution 4 grains to the ounce), in an hour and a half the nearest point was, left eight inches, right twelve inches; then Physostigma was used, and in half an hour could only see distinctly between six and a half and nine inches; after this Physostigma gradually predominated, and near vision became distinct, 19.
Visual acuteness often sinks to one-half the normal under its use, 10.
Objects distant more than one foot seem dim and indistinct; all objects seemed nearer and larger; pupils unchanged (after ten minutes); pupils contracted to one line in diameter (normal size, two lines); objects distant more than nine inches are dim; all objects seem one-half larger and nearer (after twenty minutes); pupil two-thirds of a line (the other pupil two and a half lines diameter); no distinct vision beyond eight inches (after thirty minutes); pupil one-half line (other pupil normal); on reading, heaviness and fatigue of the eye; dull aching and heaviness on using the eyes; eyes feel strained (after seventy minutes). In a subsequent experiment, concave eight enabled him to see at a distance, but not nearer than five inches, 19.
One observer could bring his vision with perfect clearness to the normal, but only with very great and painful exertion, 10.
Dimness of vision (after sixty minutes), 2.
Sight bad at all times; rather dull; clouds passing over the sun interrupt his walking (second day), 41.
For the last three days he has had attacks of partial blindness; on attempting to write he was unable to see the line (sixth day), 31.
Letters seem in constant motion, and can only be seen at a large visual angle, 10.
Bright daylight seems like twilight, the result of the largely contracted field of vision, 10.
Vision seemed hazy or misty, while walking; better at once by keeping quiet (fourth day), 54. [230.]
Bright marks when looking at an object; dark-yellowish spots on book when reading, covering one or two of the letters, 65.
Muscæ volitantes, both black and white (tenth day), 33.
Had muscæ volitantes very much (fourteenth day), 33.

EAR

Pressure on the tympanum of each ear, which is painful (second day), 31.
Uncomfortable sensation in right ear; felt inclined to bore in with the finger; picked the ear and removed some wax, after which slight pain (after one hour and a half); with eructation , a sudden pain running from the throat along the Eustachian tube to the middle, leaving a transient stabbing pain in the middle ear; the pain to the ear repeated; the uncomfortable sensation (desire to bore) occurred repeatedly for several successive evenings, 39.
While writing, felt pain in right ear (fourth day), 61.
Considerable sharp pain in right ear, with the stiffness of the neck (third day); only a little soreness remaining (fourth day), 66.
Sharp shooting pain in the right ear, at 6.45 P.M. (fourth day), 71c.
Shooting pain in the left ear, at 3 P.M. (fifth day), 71b.
Fulness in ears (third day), 50. [240.]
Sensation of crawling feeling in left ear (third day), 46a.
Ears feel as if stopped up (ninth day), 50.
Hearing.
The ear symptoms were as if every sound went through the ear; ears very sensitive to sound (fifth day), 46a.
Partial deafness in the right ear, at 9 P.M. (fifth day), 71c.
Since 11 A.M., have had partial deafness in the right ear, at 8 P.M. (tenth day), 71b.
Slight deafness in the right ear (fifth day), 71d.
In the evening, hammering in right ear, while external ear felt as though hot air were blowing on it (third day), 61.
Singing or turning, like escaping steam, after lying down at night, 65.
Buzzing and ringing in the right ear, at 7 P.M. (third day), 71c.

NOSE

A small boil appeared on the inside of the right nostril; it was very painful, the pain extending up to the eye and right side of the head; it broke on the fourth day, with but little discharge (after five days), 24. [250.]
Slight epistaxis, right side, in evening (fifth day); left side, with the headache, in the morning, and while at supper (sixth day), 37.
Nose and throat filled with mucus; have had a similar sensation within a week (second day), 45.
Fluent discharge of clear coryza (after two days), 71d.
Frequent sneezing (after one day), 71d.
Sneezing (sixth day), 33.
Twitchings in the nose, and involuntary expansion of the nostrils (sixteenth day), 33.
A sensation exactly as if the nose was going to bleed, and the peculiar taste which goes with it, at 2 and 8 P.M. (fifth day), 33.
Burning heat in the nose, and sensation as if it would bleed, at 4 P.M. (nineteenth day), 33.
Nasal passages feel as if a fresh cold were coming on; smarting and tingling in the nose, and several times sneezing (after fourteen hours), 34.
Sensation of contraction in the alæ nasi and upper lip, with frequent desire to rub them, which relieved for the time; this lasted about twenty minutes (third day), 23a. [260.]
An intolerable itching and tingling of the left nostril, in the morning, with moisture of the same nostril; return of the itching, in the afternoon, with dryness of same nostril; again, in the evening, with moisture (fourth day), 67.
Nose stuffed and hot, 65.

FACE

Face flushed and red, 65.
Paleness of the face, with the headache (second day), 26.
Countenance very pale (after 12 grains), 1.
Pale face, 13, 15.
Very pale, 14.
Looked tired, in the morning (second day), 42.
Pain and flushing of the face, on rising from a sitting position (fourth day), 58.
Neuralgic pain in the right side of the face (second day), 60. [270.]
Had a curious feeling in my face; felt better when my mouth was open; at times this feeling extended down into my neck; I cannot describe it, but it seems to be of a cramping nature, or in spasms; at the time when this was the worst, my left hand became quite numb, and it bothered me to hold on to anything; this I noticed most when I went to look at my watch (fourth day), 58.
Sensation of contraction of the whole left side of the face , with slight numbness (after one hour, second day), 23.*
Occasionally severe pain in the right side of the upper jaw, like toothache, although the teeth on that side have all been extracted, with difficulty in keeping the eye open (second day), 23.
Pain in the side of the jaw where there were teeth (first day), 23a.
Fierce pains in lower jaw, right side (second day), 34.

MOUTH

Teeth.
Teeth felt rough, which brushing did not remove, in the morning (second day), 58.
Quivering sensation in the teeth, as if they were resting on a sounding-board of a piano (nineteenth day), 33.
Tongue.
Tongue coated white, and having an oily feel, with a very bad taste in the mouth (fourth day), 58.
Tongue coated slightly, more heavily towards the root (second day), 46b.
Tongue feels rough to the touch (after half an hour, second day), 49a. [280.]
Tongue dry and rough and sore (fourth day), 61.
Dryness and smarting of the tip of the tongue and lips continued all day (first day); dryness and smarting of the tongue the same as yesterday (second day), 23.
A raw feeling of the tongue, very disagreeable in swallowing, 52.
Tongue felt as if scalded (after twenty minutes, fourth day); the scalding sensation was all on the left side (fifth day); continuance of scalding (sixth day); felt on right side (seventh day); the scalding of tongue still continued, although the surface felt well (eighth and ninth days), 23a.
The tongue became very sore on the left side, quite back to the root, and it was very hard to move it, as if it was stiff, lasting nearly a day (fourth day), 33.
Tongue felt sore on tip and rough, at 4 P.M. (third day), 61.
Smarting of end of tongue ; feels as if burnt by hot liquid, 65.
Numbness and tingling smarting of the tongue and lips, with a constant desire to moisten them (after fifteen minutes), 23a.
General Mouth.
Involuntary twitching of the mouth, also of the eyebrows , and beating or throbbing and twitching between the eyebrows, also numbness from between the eyes down through the nose, at 8 P.M. (sixth day), 33.
The roof of the mouth feels as if covered with patches of loose skin; has a yellowish copper-colored appearance; at 9 P.M. (fifth day), 71c.
Taste. [290.]
Metallic taste in the mouth, at 9 P.M. (fifth day), 71c.
Taste in the mouth like creosote, on waking, in the morning (second day), 49.
Very bad taste in mouth; have had similar symptom within a week (second day), 45.
Bad taste in the mouth, full of saliva (after half an hour, second day), 49a.
Bad taste all day (third day), 61.
Arose in the morning with a bad taste in my mouth, as though I had been confined in a close room all night (second day), 38.
Saliva.
Profuse salivation (second day), 58.
Thick lathery saliva from whole buccal surface, though drug at once swallowed, 6.
Mucus ran from the mouth, 20.
Speech.
Power of speech retained long after inability to swallow, 20. [300.]
Felt a sluggishness of articulation, and to avoid any show of this, made a strong effort of the will to speak slowly and firmly (after 12 grains), 5.

THROAT

Throat and nose filled with mucus; had a similar sensation within a week (second day), 43.
Collection of clear mucus in the throat, at 6 P.M. (third day), 71a.
Throat became very sore, with a feeling of a fishbone lodged in throat; swallowing of saliva very painful; at 9 P.M. (second day), 44.
This evening (9 P.M.) my throat is very sore; tonsils and soft palate inflamed, dark-red, with stinging pain (fifth day); throat not so much inflamed (sixth day); smarting of left tonsil (after a quarter of an hour); left tonsil slightly inflamed; radiating redness of tonsil (after half an hour, eighth day); back part of throat very sore this evening (ninth day), 46.
Throat very sore, especially when swallowing, at 8 P.M. (fourth day), 71a.
Back part of throat very sore, at 8 P.M. (tenth day), 48.
Sensation of soreness in the throat, at 2 P.M. (second day), with constricted feeling when swallowing (fourth day); throat quite sore, at 5 P.M. (fifth day), 71b.
Throat began to be sore on the right side; seemed to be a little spot not larger than a pea, which bothered me a great deal in swallowing (second day); still sore at right side (third day), 56.
Throat quite sore; burning-scraping raw feeling, with a constrictive feeling when swallowing; at 7 P.M. (first day); throat much improved (fifth day); slightly sore (thirteenth day), 71d. [310.]
Slight soreness of the throat, when swallowing (fourth, fifth, and eighth days), 71 ; (8 P.M., second day), 71c.
Slight soreness of the throat, worse when swallowing (second day), 71.
Throat full (third day), 61.
Had a feeling as if a ball were coming up to the throat, 7.
A painful constriction of throat; soreness felt all through the posterior portion of pharynx, with painful swallowing of saliva, at 7 P.M., throat became dry by 10 P.M. (fourth day). The pain and constriction of pharynx still continued, and examination showed small ulcers, with yellow centres, on right side of pharynx, behind tonsil; posterior nares also dark-red, at 4 P.M. (fifth day). Throat very sore; very difficult to swallow; surface studded with fine ulcers, especially on right side, where the pain is greatest, from 4 to 10 P.M. (eighth day). Uvula considerably elongated, and though I have discontinued medicine for two or three days, the throat symptoms continue, though less violent (tenth day), 44.
Constriction of throat and difficulty of swallowing (after five minutes); during the whole afternoon the throat was very sore, examination showing enlarged tonsils and elongated uvula; swallowing of saliva or speaking very painful; the posterior part of tongue also very painful to touch; saliva was not increased (sixteenth day), 44.
Constricted feeling of the throat, when swallowing, in the evening (second day), with great soreness at 6 P.M. (third day), 71a.
Throat felt constricted, as before, except that it was higher up (second day); very much constricted, and great difficulty in eating, passing away before breakfast was eaten; examination shows the posterior superior portion of mouth injected (third day), 41a.
Throat very painful, when swallowing; raw scrapy burning sensation in the throat, at 9 P.M. (fifth day), 71c.
Pain extending from the throat to the left ear, when swallowing, at 3 P.M. (fifth day), 71b.
Œsophagus and External Throat. [320.]
All gone feeling along the œsophagus (third day), 44a.
There was noticed, while he was sleeping, an unusual pulsation of carotid arteries; upon examination, the action of the heart was found to be irregular (third day), 32.
Submaxillary gland very tender and tumefied (fourth day), 58.

STOMACH

Appetite.
Appetite increased (fifth day), 67.
Hunger, but can find nothing to satisfy it; disposed to try one thing after another; food has a flat taste, 65.
No appetite (fourth and sixth days), 46.
Loss of appetite (sixth day), 67.
Appetite not very good for breakfast (second day); no appetite for breakfast (third day), 54.
Appetite not so good as usual, with occasional nausea (first day), 34.
At times I noticed that I did not care for eating; appetite previously good at any time, 52. [330.]
Less appetite since taking the medicine (seventeenth day), 33.
Bad appetite (second morning), 5.
Morbid appetite (fourth day), 71b.
Declined food (second day), 12, 13.
Disinclined for breakfast; no appetite (second day), 42.
Perfect disgust for food of every kind, during the whole proving, 58.
Disgust for food, for tobacco, and coffee, and especially for cold drinks (I am a great water-drinker), (third day). There is not so much disgust for food, still I do not relish my usual cup of café au lait , and the toast remains untouched; no appetite (fourth day). Ate some light breakfast from mere habit, but still no desire for food (fifth day). Ate a very light breakfast, with very little relish (sixth day), 38.
Thirst.
Began in ten minutes to have thirst, which increased till they begged for water, then the power of swallowing was lost, 20.
They suffered greatly from thirst, and drank readily large quantities of warm water, 14.
Very thirsty, in the afternoon (seventh day), 48. [340.]
Have had no thirst at all to-day; usually drink considerable with my meals; drank scarcely any to-day; somewhat thirsty this evening, which may be due to eating beans at tea (second day), 46b.
Great desire for cold water all the evening; the more I drink the more I want (second day), 46a.
No thirst (sixth day), 46.
Disgust especially for cold drinks (third day); no thirst (third to sixth day), 38.
Eructations.
Repeated eructations from stomach of warm air, tasteless, 39.
Eructations (after six minutes), 4.
A good deal of tasteless eructations, without relief (tenth day), 34a.
Tasteless eructations, 65.
Empty eructations, at 7 P.M. (third day), 71c.
Several empty eructations (two hours after second dose, second day), 61. [350.]
Eructations, without the epigastric sensations, considerable nausea, and dizziness (after one hundred minutes), 2.
Some eructations at 4 P.M. (second day), 44.
Hiccough.
Violent and very unusual hiccough for forty-five minutes, with great distress for breath; relieved at once by sleep, at 8.30 P.M. (second day); on waking again, violent hiccough, half hour, at 2 A.M. (third day), 44.
Three distinct hiccoughs, followed by belching of tasteless gas; something unusual, but don't know that it is a symptom (after one hour), 54.
Hiccough, from 5 P.M. until 8 P.M., of violent character (third day); hiccough from 9 P.M. till 11 P.M.; ceased on retiring (eighth day), 50.
Nausea and Vomiting.
Nausea, and sinking feeling in the stomach, immediately, 6.
Nausea (after seventy-six minutes), 1, 15 ; (after one hour), 36a ; (after half an hour, second day), 49a.
Constant nausea, but no vomiting, only some waterbrash (third day), 38.
Nausea and qualmishness, with the headache, 54.
On waking, in the morning, nausea (second day), 49. [360.]
Nausea on lying down, though none was felt before (after two hours, second day), 44a.
Nausea (third day); constant, with some relief after vomiting (fourth day), 71a.
Nausea, at 10 P.M. (second day); in occasional attacks (fourth day); slight nausea, with chilly creeps passing up the back, at 2 P.M. (fifth day); slight nausea and vertigo, at 4.30 P.M. (seventh day), 71b.
Nausea, caused by the pain in the orbit (second day), 55.
Breakfast caused slight nausea (second day), 46.
The sound of the organ caused nausea (second day), 66.
Slight nausea, in the morning; very distinct nausea in throat, feeling as if he would be sick, at noon; could not eat much dinner, at 1 P.M., on account of the nausea; he had to lie down, which relieved the nausea, after which he could eat a little more; after again resting, all symptoms passed off (second day), 42.
Slight nausea; this nausea does not seem to have any reference to eating, as it sometimes has come before and sometimes after eating (eleventh day), 23.
Slight nausea (at 10 A.M., fourteenth day), 33 ; (after one hour), 36 ; (after fifteen minutes), 36a ; (at 3.40 P.M., third day), 45 ; (at 3 P.M., second day), 68 ; (at 7 P.M., third day), 71c.
Sick at the stomach (third day), 41 ; (eighth day), 48. [370.]
The smell of Havanas was disgusting and sickening (third day), 38.
Should nausea or vomiting set in, they often recover, 20.
Inclination to vomit (after a quarter of an hour); after copious draughts of water and mechanical irritation he produced vomiting, with great retching, followed by collapse, with cold sweat in drops over the whole body, 18.
Copious vomiting; he was so feeble as to be unable to completely eject the vomited water, 13.
Short attacks of vomiting and diarrhœa (first day), 28.
Vomiting commenced soon in most of the cases, 14.
Vomiting of acrid fluid (second day), 60.
Stomach.
Pricking sensation in the stomach and abdomen, followed by rumbling, and slight colic pains in the region of transverse colon, lasting nearly an hour (after one hour); pricking sensation in the stomach and bowels, at 9.30 A.M. (second day), 54.
During the pain, sensitiveness over the region of the stomach to pressure (tenth day), 34a.
Hard pain in the stomach (the next day), 35. [380.]
Sharp pains in the stomach, shooting upwards, at 9.30 A.M. (second day), 54.
After dinner, upon going out of doors, had a pain in my stomach, which caused me to feel sick at the stomach; this pain was followed by a crampy feeling in fundus of bladder (second day), 46.
Griping pains in the stomach and great oppression (after two hours and a half), 36a.
Crampy pain in stomach, with the desire for stool (eighth day), 48.
Transient pains in stomach, with sensation as of undigested food (after seven hours and a half), 36a.
Burning sensation in the stomach, with hot eructations (after three hours), 36.
Heaviness in the stomach (after half an hour), 41.
Weight in the stomach, as from undigested food (after one hour), 36.
A feeling as if a hard body were lying in the stomach, like undigested food (after fourteen hours), 34.
Stomach pressed (third day), 61. [390.]
My food lay hard in my stomach all day (third day), 46b.
Stomach effectually emptied after drinking the shaving water which I had just used; later, I could not vomit; the abdominal muscles acted too feebly; the sickness ceased, and never returned (after 12 grains), 1.
Feeling of emptiness in stomach and bowels (sixth day), 67.
Sense of emptiness and weakness at stomach, without hunger, at 3 P.M. (seventeenth day), 33.
Felt as though (mucous coat?), (of) stomach swelled, continuing all day (two hours after second dose, second day), 61.
Felt slight contraction in region of stomach (second day); contraction [It is to be noted that what one prover distinguished as contraction, another describes as swelling of stomach.] in region of stomach more plainly marked, continuing four or five days, attended with dull pain in left side and forepart of head; not relieved by food; appetite as usual (after three days); the symptoms began to diminish on the sixth day, and had disappeared about the eighth day, 63.
Stomach unsettled (after four hours and a half), 36a.
Slow digestion (second day), 60.
Griping pain in the pit of the stomach (after four hours and a half), with soreness to pressure (after ten hours and a half), 36.
Sensation at the pit of the stomach as if undigested food oppressed it (after one hour, third day), 34. [400.]
A breathless sensation at the pit of the stomach, with a hard feeling as of undigested food; a disposition to make deep inspirations: these sensations were momentary, coming and going (after one hour and a quarter, second day; after one hour, third day), 34.
Trembling of the nerves at the pit of the stomach, accompanied with slight nausea, and a sensation of faintness (fifth day), 33.
Felt the nervousness at the pit of the stomach, in front of the body most (ninth day), 33.
Soreness at the pit of the stomach, at 10.30 A.M. (seventeenth day), 33.
Much weakness at the pit of the stomach, with the nervous symptoms (fifteenth day), 33.
Violent epigastric symptoms (after three minutes), 4.
Epigastric sensation perceived (after five minutes), 5.
Epigastric sensation, accompanied with eructations (after five minutes); slight sensation in the epigastric region (after fifteen minutes); more intense and accompanied with eructations (after twenty minutes); epigastric sensation recurs, without eructations (after thirty minutes); sensations in epigastric region occur in quick succession (after fifty-five minutes), 3.
Epigastric region sore to pressure (after seven hours and a half), 36a.
Violent oppression in the epigastric region (after a quarter of an hour), 18. [410.]
Complained of severe pain in the epigastric region, and begged that he might be laid upon the bed, 12.
At 2 A.M. was awakened by a pressive pain in the epigastrium, just under the ensiform cartilage, extending up into the chest and down the arms; pain in epigastrium seemed to be produced by hard pressure against the lower end of the sternum, and extended all along the lower edge of the ribs, at the attachment of the diaphragm, and through to the back to about the third dorsal vertebra; the sensation was as if the pain was squeezed out into the arms; the pain seemed to alternate between an ache and an acute quick pain, but was occasionally pulsative (after ten days), 34.
Darting pain in epigastric region (after four hours); have felt the pain in the epigastric region all the time, except when asleep (after twenty-five hours and a half), 36.
Soreness and transient pains in epigastrium (after four hours and a half), 36a.
A slight degree of peculiar sensation in epigastrium (after ten minutes); recurred (after forty minutes); much increased; it now resembles the somewhat painful sensation which is produced when large pieces of food are suddenly swallowed, and recurs at intervals; it is at first slightly indicated by a sensation in the thorax, near the upper part of the sternum; this extends downwards, becoming more and more intense until it reaches the epigastrium, when it is almost painful, and eructations usually occur; there is a distinct escape of gas, and this is followed by a reversal of the direction of the pain from the lower sternum to the throat, so that eructations occur at the middle of this sensation (after fifty minutes), 2.

ABDOMEN

Hypochondria.
Darting pains in right hypochondrium (after two hours and a half), 36a.
Griping pains in right hypochondrium (after half an hour), 36a.
Sharp lancinating pains in left hypochondrium, left thigh, and left forefinger, passing off very soon, and immediately followed by a sharp pain in the region of the liver, passing upwards and towards the sternum, lasting but a few minutes, at 9.50 A.M. (second day), 54.
Woke up heavily (not unusual), with considerable stiff pain in region of liver, posteriorly (second morning), 42.
Considerable stiff pain in region of liver, posteriorly, in the morning, on waking; tender on slight pressure, and on first moving; went off after moving a little (second day); same pain in liver region returned, in the morning (third day), 42. [420.]
Pain in the region of the liver, at 10.25 A.M. (second day), 54.
Hard sore pain in splenic region, descending to inguinal region, across hypogastric region, quite severe and increased by motion; in the evening the pain was so severe it caused me to extend the legs (three hours after second dose, second day), 61.
Sore pain in spleen, for two hours (third day), 61.
Umbilicus and Sides.
About 6 P.M., felt soreness in the umbilicus, and a sensation as though corset had pinched it; on examination, about 8 P.M., found the part very much inflamed (blood-red), very sore, and could not bear the contact of the clothing (fourth day); the following morning, inflammation somewhat decreased, but part still sore; soreness and inflammation continued about four or five days, growing gradually less, 57.
Drawing pain in umbilical region (seventh day), 67.
Pain in the umbilical region (second day), 49.
Sharp pain in the umbilical region (fifth day), 67.
Severe pain in the umbilical region, 13.
Severe colicky pains in the left side of the abdomen (second day), 68.
At 4 A.M., he arose with a soreness, not a pain, in the left side of the abdomen, which was painful on pressure; at 8 A.M., the soreness continued; it was painful when moving about, and was aggravated by riding; this soreness covered a spot as large as the palm of the hand, and continued five days, 24. [430.]
Slight stitches in the left side of the abdomen (third day), 27.
General Abdomen.
Rumbling in bowels, at 10 P.M. (fifth day), 51.
Rumbling in the bowels, as from wind; some passed off (third day), 45.
At 8.40 P.M., rumbling and gurgling with heat in the abdomen and slight colic pains; the symptoms, except colic, continue till 11 P.M. (after twelve hours and a half); bowels feel full, with some rumbling and heat (second day), 54.
Gurgling in the bowels, with the sensation as if diarrhœa would set in (fifth day), 38.
In morning, before second dose, and lasting all day, noisy emission of flatus from bowels (second day), 42.
Unusual escape of flatus per anum (second day), 44.
Great amount of flatulence, smelling like carrion (fourth and fifth days), 71.
Discharge of much foul-smelling flatulence, from below (third day), 46b.
Passed great quantities of flatus (after six hours); great quantities of flatus passed; this seems to be generated in the rectum, as there is neither distension or rumbling in the abdomen; it is first perceived just as it is ready to escape, and if restrained, rapidly augments in volume; there is very little odor (ninth day), 43. [440.]
Passage of much wind, odorless, 65.
Called up by quite severe colic, during stool and relieved by stool, at 6.30 A.M.; another slight attack of colic; seems to be flatulent, at 7 A.M.; before and during stool, at 9 A.M., 3.40 P.M., at 6.30; slight colic before discharge, at 10.15 (third day), 45.
Sensation of heat in the abdomen, with the headache (second day), 54.
Bloated feeling of the abdomen (fourth and fifth days), 71.
A sense of distension, with soreness of abdomen (second morning), 30.
(Have had uneasiness in the abdomen all the morning, as though bowels were loose, and I should have colic; have had similar symptoms within a week; some uneasiness in the abdomen, as if the bowels were about to move, at 5.30 P.M.; there has been a remission of these feelings during the day; at 8.30 P.M., rattling in the abdomen, with feeling as though the bowels were about to move, and that the stool would be diarrhœic (second day), 45.
Bowels feel uneasy, as if they would move soon, at 5.50 P.M. (second day), 54.
A feeling of looseness of bowels, with slight desire for stool, at 3 P.M. (second day); am usually regular at stool, occurring every day about 7 P.M., 45b.
The bowels feet as if they would move at any time, at 3 P.M. (third day), 54.
Pain in the bowels, which seem to be distended with gas; could sit up only a short time, when I would be compelled to lie down again, on account of the pain in bowels; this pain was worse every time I stood erect (third day), 58. [450.]
Woke about 4 A.M. with griping pain in bowels; griping pains usually before the stools, but not much relieved by the stools, Verat. alb. 30th, and old rye whisky failed to relieve; at 10 A.M., a dry griping pain in the colon transversum (or stomach?), (third day); slept moderately well, but the paroxysmal light gripes disturbed me; as long as I lay on my right side, well covered up, I could rest and doze, but as soon as I turned on my back, the griping returned with full force, and was only relieved by turning on my right side again (third night). The least motion increases the dry griping pains in the upper part of the abdomen; they differ somewhat from yesterday, as they extend to the back, causing there a lame sensation, as if support was needed; towards evening the griping steadily increased (in spite of Dioscorea and Lilium), and the warmth of bed was early sought for relief (fourth day). The gripings continued the same till about 3 A.M. (relief by lying on right side, aggravation on back), when I rested more quietly till about 7 A.M.; off and on still griping pains (fifth day). Off and on the reminiscences of the old intestinal cramps, but no flatus (sixth day). Sometimes still some crampy sensation in pit of stomach (seventh day), 38.
At 3 A.M., was awakened with distressing pain in the abdomen, not relieved until 11 A.M., after the stool (fifth day), 71c.
Severe pain across the abdomen (transverse colon), (after half an hour, second day), 49a.
Pinching crampy pain in the abdomen, at 3 P.M. (third day), 71b.
Clutching pain in the abdomen, at 4.30 P.M. (seventh day); before the stool, at 7.30 A.M. (ninth day), 71b.
Dull pain in bowels, with feeling of looseness (second day), 51.
Pain in bowels during stool (tenth day), 48.
A few complained of pain in the bowels, but not at first, 14.
Pain in region of the arch of colon, mostly on right side, with stitches of pain extending through to back; pain increased, at night, so as to frequently wake me up, 52.
Considerable pain accompanying stool; pain being located just below the umbilical region (sixth day), 51. [460.]
Sensation of fulness and dull pain in transverse and descending colon (fourth day), 37.
Hypogastrium and Iliac Regions.
Soreness in left side and hypogastric region, hurting me to stand (third day), 61.
A former pain in right hypogastric region, which had now been absent for two years, returned more troublesome than it usually had been (fifth day), 28.
In the evening, colicky pains, low down in the abdomen, were succeeded by a copious loose discharge from the bowels (third day), 30.
Tenesmus and dull pain in transverse and descending colon, with the diarrhœa, 37.
Sharp and cutting pain in the lower part of the abdomen, more as if in the muscles than the organs (fourth day), 49.
Drawing pain in the right iliac region, relieved by lying on the right side, by pressure, on walking in the open air, and eating; worse by lying on back and left side (second day), 49a.
Shooting pains in the left iliac region (after thirteen hours), 34.
Pain in the groin, alternating from left to right, at 6 P.M. (third day), 71a.
Dull pain in the groin (fourth day), 71b. [470.]
Occasional shooting pain in the groin, extending into the right testicle (fifth day), 71b.
Pain in the groin, with slight swelling, at 8 P.M. (eighth day), 71b.
Pain in the groin, at 7 P.M. (third day), 71c.
Pain in the groin (after one day); constantly (fifth day); slight (seventh and eighth days), 71d.
Slight pain, extending from the left hip into the groin, at 2 P.M. (second day), 71b.

RECTUM AND ANUS

Sphincter ani swollen and rigid; evacuation painful; rectum protruding, swollen, and very sensitive (third day); anus still very painful (fourth day); hard lumps, like piles, protruding and very painful (fifth day); piles worse, burning, and very sensitive; used Cosmoline with excellent effect, as it quickly allayed the burning (sixth day); piles better during the day; at night the burning pain was so great, could get no rest till Cosmoline was applied, when I soon fell asleep (seventh day); piles much worse; one large soft protuberance on the left side of anus, and two large hard lumps, that seem attached to the sphincter, on the right side; they are dark-blue and very painful (eighth day); piles very hard, protruding, and causing great pain, while sitting or walking; the suffering was so great I took Physometra, 50 m. F.; shortly after taking it the pain and soreness lessened, and I slept well (ninth day); found the pain all gone and the piles decreasing in size (tenth day); had entirely disappeared (eleventh and twelfth days), 43.
Soreness in the rectum and urethra, and suspect I have taken cold (third day), 45a.
Return of piles, which have not troubled him for three years, 65.
Tenesmus, at 4 P.M., continuing an hour, when there was an evacuation of a soft thin stool; the tenesmus was a feeling all the time as though he had been to stool (third day), 30.
Tenesmus after the stool (third day); before and after the stool (seventh day), 71b. [480.]
Tenesmus of rectum with the diarrhœa, 37.
Desire for stool, but was much constipated; fæces hard and not much in quantity (three hours after third dose); three hours later, a very loose diarrhœa (watery) with some flatus. Some five days since the proving has affected me, and yet inclined to looseness of bowels, 52.
Anus sore, inclined to protrude a little (as if from relaxed sphincter), 65.
Burning at the anus with the stools, 45.

STOOL

Diarrhœa.
Freely purged, 13.
Purging in a few cases, 14.
Short attacks of diarrhœa and vomiting (first day), 28.
Large diarrhœic stool, with burning at anus, at 8.45 A.M. (bowels had moved just previous to taking the drug, and am nearly always constipated), (second day), 54.
Diarrhœic stool, with burning at the anus, at 8.10 A.M. (third day), 54.
Stool very loose and weakening, 65. [490.]
Soft thin stool, followed by great exhaustion; color of stool quite natural (third day); stool light-colored and very soft, not thin or watery (eighth day); quite thin and light-colored, followed with tenesmus, in the morning; thin at 12 M.; stool soft, and some tenesmus, at 9 P.M. (ninth day); quite natural (tenth day), 50.
A very copious stool, at 11 A.M.; passage from bowels of a yellowish color and soft consistency, at 3.30 P.M.; usually have but one passage from bowels each day, sometimes go two days; evacuation of a foul smell, at 6.30 P.M.; stool at 10. 30 (second day); stool at 6.30 A.M. (third day). Since proving, have been having two or three stools a day, at irregular times, not large, yellowish, 46b.
From 5 A.M. to 9 A.M., had about eight to nine large watery stools; the first ones mixed with fecal matter, the later ones light-yellow, watery, gushing out in a stream, with faint feeling, and cold sweat on the forehead; griping pain usually before stool, but not much relieved by the stool; the continual calls of nature drove me up, although the stools were, by 10 A.M., not more than a tablespoonful, and odorless (third day). Several times (two or three) a desire for stool, but only a small quantity of water escaped, and once some very foul-smelling flatus (fourth day). A bilious stool at 10 A.M. (fifth day), 38.
Soft, large, brown stool, at 7 A.M.; small thin yellow stool, smelling sour, at 2 P.M.; a small watery one, mixed with undigested food, smelling very sour, at 7 P.M.; small watery, at 10 P.M. (second day). Thin watery, with tenesmus afterwards, at 4 P.M. (third day). No stool (fourth day). Voided a large stool, part of which was natural looking, remainder black, like tar, at 7 A.M. (fifth day). Voided a natural-looking stool mixed with black lumps, followed by a small discharge of mucus, at 6 P.M. (sixth day). Small, thin, lumpy, stool; tenesmus before and after stool, at 4.30 P.M. (seventh day). Small hard stool, covered with a jelly-like slime, at 7, and again at 7.30 A.M. (ninth day). Natural-looking stool, at 7 A.M. (tenth day), 71b.
Bowels, which had been somewhat costive, moved twice, in the morning; two soft stools after dinner, with tenesmus and dull pain in transverse and descending colon; last stool fetid and brownish; two stools in the evening, with similar pains and tenesmus during and after stool; stools soft, brownish, and fetid, slight tenesmus of bladder at the same time (fourth day). Two soft mushy stools after breakfast, with same kind of pains; same kind of stool and pain, and tenesmus of bladder, after dinner and supper (fifth day). Same kind of stool after breakfast, with tenesmus of rectum and bladder, during and after stool (sixth day). Constipation during the day I took none, and when I recommenced had four passages in one day, but not loose, 37.
Feel for a half hour before stool as if had been to stool (eighth day), 50.
Stool, first regular, then irregular and loose, 65.
Bowels move, but not a profuse discharge; stool of a yellow color, at 5.10 A.M. (sixth day), 51.
No movement of bowels (second day); desire several times without stool (third day); one small hard stool (fourth day); very copious discharge from bowels, light-colored, with intense crampy pain in lower part of bowels while at stool (not often), in the forenoon and again at 4 P.M. (fifth day); had an operation from the bowels; it was nearly impossible to pass stool owing to the contraction of the sphincter, at 8 P.M. (seventh day); desire for stool early this morning, while in bed, with crampy pain in stomach, but after getting up the desire for stool left me (eighth day); constipated (ninth day); stool, with much urging, very hard and dark-colored; pain in bowels during stool, at 9 A.M.; urging, with passages of stool much lighter than usual, at 9.05 A.M.; very copious diarrhœic stool, yellow-colored, with burning-smarting pain (all three stools within fifteen minutes), (tenth day); constipated (eleventh day), 48.
Had a natural stool, at 9.30 A.M.; one of softer consistency than natural at 11.40, another at 4.45 P.M. Desire for stool, but no stool, although I strained very hard, at 10.30 P.M. (second day). Operation of bowels at 6.15 A.M., of a slightly yellow color and foul smell; soft consistency, at 2.10 P.M. (third and fourth days). Had been constipated very much for years; no operation without injection. Have a desire for stool every night, and a copious evacuation every morning since the proving (fifth day), 46a. [500.]
Stool neither hard nor soft, but dark and offensive, at 6.30 A.M.; discharge, with colic before and during stool, with some burning at the anus, at 9 A.M.; desire for stool, with rumbling in the bowels, at 3.40 P.M.; soft stool, with some colic before and during discharge, at 6.30 P.M.; large offensive stool, with some tenesmus, and slight colic before the discharge, at 10.15 P.M. (third day), 45.
Constipation.
Constipated (fourth and fifth days), 71.
Bowels excessively constipated (a very unusual condition with the prover), (tenth day), 34a.
Constipated (very unusual), (second day), 36a.
Bowels constipated (third day); have had no operation to-day (fourth day); none to-day, but have urging without stool (fifth day); desire without stool, at 9 A.M., and again at 11 A.M., with much urging and straining (sixth day); operation from the bowels large, light-yellow color, and soft consistency, at 7 A.M.; operation of bowels, soft consistency, at 9 A.M.; desire, without stool, at 12 M. and 7.30 P.M. (seventh day); operation from bowels, at 7.30 A.M.; stool, with much straining to pass a small amount, at 2.30 P.M. (eighth day); desire for stool early this morning, with large stool of light-yellow color (ninth day); bowels constipated (tenth day); no stool (eleventh day); several operations from bowels (soft consistency); (twelfth day); three passages from bowels (thirteenth day), 46.
No stool for last four days (sixth day), 31.
Full, natural looking stool, at 3.45 A.M.; small stool, smelling sour, at 8 A.M. (second day); natural-looking stool, at 11 A.M. (fifth day), (bowels had not been moved for sixty-nine hours previously), 71c.
Stool lumpy, mingled with watery discharge (first night); constipated (very unusual), (second day), 36a.
Stools very hard and in round balls, but quite easily expelled (fourth day), 58.

URINARY ORGANS

Kidneys.
Lame bruised feeling in the region of the kidneys with the headache (third day), 54. [510.]
Bruised sore feeling in region of kidneys (second day), 67.
Bladder and Urethra.
Sensation of fulness of the bladder, as from retention of urine, at 3 P.M. (eighth day), 71b.
Sensation of distension of the bladder, at 3 P.M. (third day), 71b.
Slight tenesmus of the bladder, with the diarrhœa, 37.
Crampy feeling in fundus of bladder followed the pain in the stomach (second day), 46.
Soreness in the urethra and rectum, and suspect I have taken cold (third day), 45a.
Pain in the urethra just after micturating, 58.
Micturition and Urine.
Frequent micturition (after two days), 71d.
Frequent desire to urinate; goes to the chamber several times with the inclination, but passes no urine, 65.
Almost constant desire to urinate, with the dull pain in the back, passing large quantities of reddish urine (third day), 60. [520.]
Did not urinate for the last eight or ten hours, although frequent and copious micturition is rather the rule with me (third day); hardly any urine passed during the day (fourth day); micturition freer (fifth day); urination natural, though not so frequent as usual (sixth day), 38.
Upon rising, passed more than the usual amount of urine, of a clear, slightly yellow color (second morning), 46b.
Increased secretion of urine, with difficult retention of it, in the forenoon (second day), 67.
The quantity of urine passed is slightly increased (second day); increased and of a pale yellow color, all day (third day); urine increased in quantity, and contains mucus; number of passages of urine increased; yellow color of urine; the amount of urine passed is greater than the amount of fluid I drink (fourth day); urine scanty (seventh day); passed a large amount of yellowish-colored urine containing mucus (ninth day), 46.
The urine was greatly increased in quantity, 60.
Urine increased in quantity, and yellow in color (fourth day); increased in amount (ninth day), 48.
Slight increase in flow of urine (second morning), 47.
Urine profuse, frequent, high-colored, and smelling strong, at 7 P.M. (third day), 71c.
During the pain, frequent and excessive flow of pale and odorless urine (tenth day), 31a.
Profuse flow of very clear urine; the urates were less than normal in quantity; phosphates in excess, 58. [530.]
Passed large quantities of colorless urine (second day); urine profuse and very clear; passed nearly a vesselful during the night, by nine emissions (third day), 58.
Urine of a clear yellowish color, at 7.10; passed urine at 8, 8.30, and 11 A.M.; passed a small quantity of muddy urine at 12; passed urine at 6, 9.30, and 11 P.M. (third and fourth days), 46a.
Urine high-colored, smelling strong, at 3 P.M. (third day), 71b.
Urine light-colored and very abundant (second day), 36a.

SEXUAL ORGANS

Male.
Frequent erections, with but slight sexual desire, in the forenoon (second day), 46.
Two emissions, without dreams or excitement, 65.
Female.
Pains in the womb, as if menses were coming on (sixth day), 33.
A great deal of leucorrhœa (ninth day), 33.
Leucorrhœa and much weakness, at 4 P.M. (eighth day), 33.
(At the time of taking Calabar bean, had been troubled with a bland, milk-white, stringy leucorrhœa for about two months, not at all profuse, but rather scanty; have not been troubled with it since taking the bean), 57. [540.]
My condition altogether very like that induced by profuse flooding after delivery (forty minutes after 12 grains), 1.

RESPIRATORY ORGANS

Bronchi.
Irritation of right bronchi, 65.
Cough.
Dry tickling cough, at 6 P.M. (old ailment), (sixth day), 67.
Cough, caused by tickling in the throat (after half an hour, eighth day), 46.
Slight constant inclination to cough, from filling the lungs, 65.
Slight cough; coughs till small white plug of mucus is thrown off, 65.
Respiration.
Oppressed breathing (third day), 60.
Labored respiration (first night), 43.*
Sighing respiration (after one hour), 36a.*
Yawning and sighing respiration (tenth day), 34.* [550.]
Respiration accompanied with a little difficulty, and with a slight degree of dyspnœa (after ninety minutes); requires an effort (after one hundred and ten minutes), 2.
In the morning his breath was offensive (third day), 32.
During the proving there was shortness of breath, and a sensation of collapse of the lungs, as if all the air was expelled at each expiration, causing long and deep inspirations and a sighing expiration, 43.
Dyspnœa, at 10 P.M. (second day), 71b.

CHEST

Cannot fill left lung, as it produces a dull pain in upper part, relieved by pressure, 65.
Stitching pain near the apex of the right lung, at 5 P.M. (fifth day), 71b.
Soreness around the body at the waist, at 6 P.M. (fourteenth day), 33.
The severest pain in the left side, and entirely unlike any pain in the lungs that I have had, 33.
Pain in right deltoid muscle, which kept me awake during forepart of night, which was relieved only by violent motion (pain, nervous, uneasy), 57.
A slight pain in right side in region of sixth and seventh ribs, at 7 P.M. (eighth day), 50. [560.]
Severe muscular pains beneath the clavicles, extending down the inner sides of both arms, at 3.45 P.M. (fifteenth day), 44.
Slight twitches across the pectoral muscles (after 12 grains), 1.
Awoke with stitches in left breast; unable to take a long breath; symptoms continued all day; pains were so uncomfortable that no more medicine was taken (fourth day); pain in left side all gone (fifth day), 62.

HEART AND PULSE

Heart.
Dull pain in region of heart, lasting nearly an hour (after three hours), 62.
Uneasiness and distress about the heart, mostly without violent palpitation, but with a fulness and pulsation over the body, so that I counted the pulse, 72, by the ear; this uneasiness is principally at night, causing restlessness, tossing from one side to the other, with dry heat all over, 43.
I took a cup of strong coffee, after which I speedily felt an indefinable change within me, and on examining the condition of the heart, I found it had become perfectly and permanently regular (five hours after 12 grains), 1.
Violent palpitation of the heart , with the nervous motions (fourteenth and fifteenth days), 23.*
Violent palpitation of the heart, with throbbing all over the body, at midnight (first day), 43.
Woke about 2 A.M., with a rapid tumultuous action of the heart as in high fever; but there was no unusual heat (fourth day), 43.
Happening to get upon the left side, my attention was, for the first time, directed to the tumultuous action of the heart, which compelled me to turn again on the back, to escape the strange sensation (after 12 grains), 1. [570.]
As the fresh bracing air strikes me , a choking sensation, with fluttering of the heart (suffered frequently from this nervous affection between the age of sixteen and twenty) overcame me, and oppressed me during the whole forenoon; I heard and felt the fluttering of my heart in the throat, with the sensation of faintness by motion, and some relief in a recumbent sitting position, not by lying down (Bromine 50

without relief); fluttering keeps steadily on, with attacks of vertigo, towards evening, especially when changing position; heart's action irregular, thus about its action, --- --- ---, v v v , one, two, intermission; one, two, three, intermission; one, two, three, four; the choking sensation in pit of the throat is steadily present; sometimes it seems to me as if I could hear every artery of my body heat; I took a dose of Sulphur 30 ; in about twenty minutes afterwards a severe aggravation set in; I had to lean forward to catch my breath; deep sighing relieved me; hot sweat stood on my forehead; my hands were cold and damp; this lasted about a quarter of an hour, when the spasmodic action of the cardiac ganglia gradually ceased and I had a comfortable evening (fifth day). Heart's action still irregular, and sometimes tumultuous; radial pulse weak, 75, every eight to ten minutes beat intermitting (sixth day), 38.

While sitting still, he felt a pulsation through the whole body, particularly in the chest; each beat of the heart was distinctly perceptible in the chest and temples (after thirteen hours, third day, and other times), 26.
The heart and pulse extremely feeble and tumultuously irregular (forty minutes after 12 grains), 1.
Could readily count my pulse in the carotids, and hear the two sounds of the heart as my head lay upon my pillow (second day), 58.
Pulse.
Pulse accelerated (fifth day), 37.
Acceleration of pulse (96), usually about 74 (tenth day), 34a.
Pulse of right side nearly double in strength that of the left (fifth day), 44.
Pulse 60, at night (first day); 74, in the morning (second day), 60.
Pulse 93 (second day), 58.
Full pulse, 72 (second day), 55. [580.]
Pulse 70 (before the proving); reduced to 65, at times, 52.
Pulse slow (after three hours and three-quarters, second day), 49a.
The pulse has been, through the whole time, from 66 to 69; when well about 70, 54.
No change in frequency of pulse till twenty minutes, when it began to diminish in frequency and strength; afterwards could not be counted, 4.
Pulse slow by several beats (fourth day), 49.
Pulse 50 to 60, with feeble impulse (sixth day), 31.
Pulse small and frequent, 18.
Extremely feeble pulse, 14.
Feeble pulse, 15.
Pulse feeble and slow, 12. [590.]
Pulse variable (after one hour), 36a.
Pulse variable, full, and strong (after one hour and a half), 36.
The pulse had been examined at different times within fifteen minutes and found to average 68 (before the experiment); 74 (after six minutes); 72 (after ten minutes); 72 (after thirty minutes); 76 (after fifteen minutes); 75 (after twenty minutes); 69 (after thirty-five minutes); 66 (after forty minutes); 68 (after forty-five minutes); 64 (after fifty minutes); 65, full and regular (after fifty-five minutes); 62, and rather feeble (after sixty minutes); 62 (after sixty-five minutes); 60, very small and wiry, but regular (after seventy minutes); 62 (after seventy-five minutes); 60, thready, and difficult to count (after eighty minutes); 60 (after eighty-five minutes); 58 (after ninety minutes); 59, very feeble, with occasional intermissions (after ninety-five minutes); 56 (after one hundred minutes); 56, thready and intermittent (after one hundred and five minutes); 58 (after one hundred and ten minutes); 60 (after two hours); 59 (after two hours, five minutes); 60, rather fuller (after two hours, ten minutes); 58 (after two hours, twenty minutes), 2.
Normal pulse, 60 to 65; at 5.30 P.M. 83, full and strong (first day); 74, full and strong (third day); 76, in the morning, not as full or strong; at 5 P.M., variable, 76, quite weak (fifth day); not having taken any medicine for three days it returned to 60, 65.
Pulse averaged 70 (before the experiment); 76 (after five minutes); 63, thready and feeble (after one hour); 54 (after one hour and a half); between 52 and 60 for one hour longer; 68, strong and full (after four hours), 5.
Three calculations of the pulse within fifteen minutes gave an average of 74 per minute (before the experiment); 76 (after three minutes); 70 (after five minutes); 72 (after ten minutes); 66 (after fifteen and twenty minutes); 68, soft and compressible (after thirty minutes); 62 (after thirty-five minutes); 64 (after forty-five minutes); 58, and very feeble (after fifty-five minutes); 60 (after sixty-five minutes); 57 (after seventy-five minutes); 54, soft and compressible, and with occasional intermissions (after eighty minutes); 57 (after ninety-five minutes); 63, rather stronger (after two hours); 58 (after two hours, ten minutes); continued to range between 60 and 70, till three hours after the commencement of the experiment, 3.

NECK AND BACK

Neck.
Inclination to stretch out the neck, "to run the head out," from uneasy sensations in the back of the neck (ninth day), 33.
Stiffness of right side of neck; not able to move the head, with a feeling of drawing and tension, which lasted several days (sixth day), 67.
Stiffness of neck on left side, 63.
While taking usual morning cold bath, was suddenly seized with stiffness in right side of neck, which extended during the day to the right shoulder, and also to clavicle, which felt sore, and was swollen over sterno-mastoid muscle; there was much pain from every attempt to move, and was relieved from leaning head towards right side; this pain continued quite acute all day, extending towards evening through right lung also; at times the pain in neck and shoulder was so severe as to cause nausea; considerable sharp pain also in right ear (third day). Stiffness in neck and pain in ear almost entirely disappeared only a little soreness remained (fourth day). A little soreness still in muscles of neck (fifth day), 66. [600.]
Pain in back of neck, reaching to first dorsal vertebra (after two hours and a half, second day), 62.
In the afternoon, a peculiar pain across the back of the neck, I should say at the base of the brain, as if it were cutting off the body from the head; it went right through the neck, and seemed to go to the back part of throat, which was stiff and sore; a feeling of loss of power and sensation in the back of head, as if the head would fall over forward, and the natural supports of the head would no longer hold it back; this was followed by pains all down the back of the neck, especially in the most prominent bone there, and on each side of it, drawing whenever the head was turned (fifth day), 33.
Soreness and pains, as from rheumatism, in left side of neck (after four hours and a half), 36a.
Seemingly rheumatic pains in left side of neck and shoulder of same side (second day), 36.
Back.
Back very weak; am unable to stand erect (continued two days), (after three days), 60.
Pain in the back came on again, at 2 P.M. (sixteenth day), 33.
Dull pain in the back, with almost constant desire to urinate (third day), 60.
Dull pain and downward pressure in the back, accompanied by the appearance of the menses (after two weeks), 27.
Chilly, creepy sensations passing up the back, at 7 P.M. (first day), 71d.
A creeping numbness over the back of the head, and all down the spine, especially in the part between the hips; between 8 and 9 P.M. (fifth day), 33. [610.]
Stiffness and pain going all down the spine; with these pains in the back there is an inclination to bend forward, as if hard to sit up straight (at 1 P.M., nineteenth day), 33.
Cramplike stitches up and down the spine, 65.
Dorsal.
After dinner there came on a heavy pain in the back, under the left shoulder, which, after continuing severe for an hour, slowly passed away, 25.
Pain under right shoulder-blade, felt while sitting, transient (deep), in the afternoon, 40.
(Pain under right shoulder-blade), (old ailment), (sixth day), 67.
Aching in region of and below right scapula, 68.
Stitches under interior angles of scapulæ during expiration, 65.
Lumbar.
Backache, which kept me restless all night; pain seemed to be in region of the kidney; no position favored the pain in my back (second day), 58.
An unusual feeling, a drawing pain low in the back and abdomen, with bearing down, as if the menses were coming, although it was a week before the time; but, after four hours, it all passed off (after third powder, on the second morning). The menses came at the right time, and without the usual unpleasant premonitory symptoms, 29.
The rest of the night, after 3 A.M., I felt a dragging pain over the left hip, towards the back; I slept, but was conscious of dull pain (first night), 27. [620.]
Dull heavy pain over the left hip, and extending to the back; this continued through the afternoon and evening, with bearing down, strongly indicative of the return of the courses; the pain diminished gradually in the night, and I slept soundly (after three hours, second day), 27.
Pain in the lumbar region of the back (after second day), 71d.
Pain in back, between the hips, and a slight feeling of numbness in the region of the womb, at 6.30 P.M. (eighth day), 33.
Soreness in lumbar region (after four hours and a half); with dull, heavy pains (after fourteen hours and a half); the severe heavy pain has followed me all day (second day), 36a.
Pain on motion, in the sacral region, to the left of the spine, as if strained by lifting, with a feeling that a violent motion would produce lumbago (ninth day), 43.
Pain in left of sacrum, in the afternoon (fourth day); in the morning (fifth day), 61.
Contractive pain of the anterior surface of os coccygis, as if dysentery were coming on; since verified (second day), 43.

EXTREMITIES

The limbs felt weary, as after great fatigue, with a constant desire to move (fourth day), 22a.
Heaviness and weakness of limbs (third day), 50.
A numb or tired feeling of limbs (fifth day), 37. [630.]
A certain pleasant feeling of slight numbness in the limbs, like that which precedes the sleep caused by Opium or Morphia, which I remarked when awake for a minute, once or twice during the night (after 6 grains), 1.
Bruised feelings in my joints (second day), 38.
Slight stiffness in the joints, at 9 P.M. (seventh day), 71d.
Pain in limbs (eleventh day), 33.
Slight pains in the limbs (seventh day), 28.
Darting pains in joints; more in the legs than arms, extending up into the body; pain in my knees, worse when I flex them (third day), 38.
Neuralgic stitches in muscles of knees and arms, 32.

SUPERIOR EXTREMITIES

Shoulder.
Sharp shooting pain in the left shoulder, at 7 A.M. (fourth day), 71c.
Rheumatic pain in left shoulder, at 8 P.M. (second day), 71.
Drawing rheumatic pains through the left shoulder (after six hours), 29.
Arm. [640.]
Nervous, uneasy pain in right arm (second day), 57.
Sharp pain, first in left arm, then in the right, involving the shoulders of either side, 35.
A momentary constrictive pain suddenly seized the left arm, extending around, just above the elbow (after ten hours and a half), 34.
The next day felt pains in right arm (as from hitting the nerve), tingling, extending from elbow down the ulnar surface and into the third finger, repeatedly for three days, 39.
Pains down the arms, with weakness of the same (sixteenth day), 33.
Tired feeling in arms, and difficulty in lifting them (fourteenth day), 33.
A dumbbell, previously used with ease, was found a great burden, and the arm was with difficulty extended with it (after twenty minutes), 3.
Numbness in the left arm (after two days), 71d.
Numbness in the left arm and down the ring finger, at 7 P.M. (sixth day), 33.
Numb feeling down the left arm (sixth day), 31. [650.]
Burning throbbing sensation in the left arm and hand, as if it had been out in the snow or cold, with the sensation felt on coming to the fire, also a nervous, tremulous, weak feeling in the arm, at 11 A.M. (sixth day), 71.
Elbow.
Sharp darting pain in the right elbow-joint, extending down the outside of the arm to the two middle fingers (third day), 23a.
Acute pain in left elbow, and darts of pain from thence to fourth and fifth fingers, same side (these pains seemed to begin in left side of neck and elbow, and thence extend to left leg, locating in left knee, and were constant for hours), (after seven hours and a half), 36a.
Forearm.
Deep pain in muscles of right forearm and wrist came on about 8 P.M., and with it a dull aching pain at times occurred (first day). Pain moving; gnawing in inner aspect of wrist, deeply situated; from wrist it ran up along ulnar side of forearm to elbow; had a desire to move the arm and work it out, which did not relieve (second day), 57.
Dull numbness of the left forearm, with stitching pain passing down the arm, at 5 P.M. (fifth day), 71b.
Wrist.
Aching in the joints of wrists and hands, also in the knees (after fourteen hours), 34.
Wrists feel weak; dull aching pain in them, 65.
Sharp pain in the left wrist, at 11 A.M.; frequent recurrence of the pain, lasting about five minutes at a time, at 8 P.M. (eighth day), 71b.
Pain in right wrist, as if squeezed and gradually let go (deep in the bone, in the afternoon), 40. [660.]
Pain in dorsum of right hand (sixth day), 67.
Hand and Fingers.
Hands powerless, 12.
Hands feel trembling, as if he must make an effort to keep them steady (second day), 42.
Numbness of the left hand, as if asleep (seventh day), 33.
Benumbed sensation in hands, very much increased by feeling of the pulse, at 11.30 A.M. (fifth day), 44.
At 3 A.M. I had ten or twelve sharp darts of pain through my right thumb, at the root of the nail, and several weaker ones through the finger-joints of the right hand (second day), 27.
Sharp pain in forefinger of left hand (sixth day), 67.
Sensation of pain in the right knuckle, as from the sting of a bee, pain lasting about two hours, at 2 P.M. (sixth day), 71.

INFERIOR EXTREMITIES

Pain in lower limbs, at 9 A.M. (tenth day), 33.
A feeling as if all the power were going out of my limbs (legs), and they would give way under me, and I could not walk across the room, as if the cause of the weakness came from the spot in the back between the hips, and took away all power below that spot from the limbs, at 6.30 P.M. (eighth day), 33.
Slight twinging pain in the lower limbs (fourth day); particularly sharp momentary twinges in the ankle (fifth day), 28. [670.]
Lower extremities felt unusually warm, 65.
A feeling of weakness, as though paralyzed, passed downward from the occiput through the back to the lower extremities; the feeling in the legs was like that known as being asleep (after fifteen minutes, second day); same feeling in legs, but the sensation less perceptible in the back (after fifteen minutes, third day), 30.
Slight difficulty in walking (after seventy-five minutes); great difficulty (after one hundred and ten minutes), 2.
Staggered and was scarcely able to walk, 12.
Staggering gait, 15.
Staggering on attempting to walk, 14.
Could neither stand nor walk, 13.
Hip.
Stiffness in the hip and knee-joints (after two days); continued stiffness of lower limbs (fifth day); slight stiffness (eighth and thirteenth days), 71d.
Slight stiffness in the left hip, at 7 P.M. (third day), 71c.
Slight stiffness of the left hip and right knee, at 9 P.M. (fifth day), 71c. [680.]
Slight stiffness in the left hip, at 2 P.M. (second day); at 9 A.M. (third day); still continues (fourth and eighth days), 71b.
Left hip and right knee quite stiff, at 6 P.M. (third day), 71a.
Stiffness in the hip and knee-joints (fourth to eighth day), 71.
Thigh.
Severe cramplike pain in the left popliteal space; walking was very painful; it lasted two hours, gradually passing off; during rest the pain ceased, but commenced again on motion; but by continued motion it was relieved (one hour after second dose, seventh day), 23a.
Pain in the left thigh, and in both knees, after walking only a few steps, about noon (fourteenth day), 33.
A few thrusts with an aching sensation down the left thigh (after thirteen hours), 34.
In the afternoon, when walking, felt a stiffness in both rectifemoris muscles (second day), 42.
Frequent paroxysms of muscular twitchings in the lower third of vastus externus muscles; these paroxysms came on every time I sat down, and so continued all day (third day), 59.
Severe aching in glutei muscles, right side, neither increased nor diminished by walking (third day), 68.
Knee and Leg.
(The knee was better, in the morning), (second day), 27. [690.]
A numb pain was felt in the knees and ankles, while sitting, with desire to move frequently (third day), 23a.
Pain on the outside of knee (thirteenth day), 33.
Shooting pain under the left knee, near or in the popliteal space, returning again and again (after twelve hours), 34.
Going downstairs, pain under the patellæ of both knees (fourth day), 49.
Weakness in the right knee, at 9 A.M. (third day), 71b.
On walking, feeling of unsteadiness from knees downwards, so that he had to tread carefully, especially when eyes are shut ; feels as if he must look to see where he is going. On going out in open air must take a stick to steady himself, and has a feeling of weakness about the ankles. Determined exertion of the will relieves the unsteadiness (second day), 42.
Cramps in calf of left leg, in bed, 63.
Intermittent, momentary constrictive pain around the left leg, just above the ankle (after eleven hours and a half), 34.
Sense of weight in the legs (after two days), 71d.
A sensation as of a drawing of cords behind the leg and the knee, making it hard to walk, especially upstairs, at 6.30 P.M. (eighth day), 33. [700.]
Gnawing sensation in the left tibia, at 2 P.M. (second day); at 9 A.M. (third day); still continues (fourth and eighth days), 71b.
Gnawing sensation in the left tibia, at 6 P.M. (third day), 71a.
Sharp twinges in the right instep (after half an hour), 26.
Foot and Toe.
Cramp in the left foot, in the evening, while in a warm bath (thirteenth day), 33.
Numbness in left foot, 65.
Pain in right great toe, transient; ache around the toe, 40.

GENERALITIES

Only one case proved fatal, a boy of six years, who ate six of the beans and did not vomit; he lived about two hours, 14.
The appearances presented were as if the nervous system had received a great shock, amounting to complete collapse, in the worse cases, 14.
Looked sleepy, listless, and depressed, and begged to be put to bed, 13.
Collapse after the vomiting, 18. [710.]
Convulsions and twitchings (especially in the back); death in thirty minutes, 20.
Trembling of legs, as if I could not walk straight, at 7.30 A.M. Seized with violent trembling all over, in the street, at 9.30 A.M. Felt for an instant as if I should lose consciousness, and could hardly get home; riding in a car for twenty minutes did not relieve the sensations; these trembling spells came on in fits, and at the least thing that startles; at 10.30 A.M. trembling of hands, so that I could hardly sew; this spell lasted an hour, when the soreness at the pit of the stomach came on (seventeenth day), 33.
Almost instantly felt a shuddering and trembling run down through all the nerves of the body; the sensations appeared to begin in the head and run down through the pit of the stomach, where they were strongest of all, and through the womb and all the body. The chief sensation in the head was the one in the middle of the forehead, between the eyes, above and over, and in the left eye a pain, with muscæ volitantes, 33.
Very restless through the night (first night), 54.
Somewhat restless towards morning (first day), 54.
Very restless in bed, not feeling satisfied in any position, at 10 P.M. (fifth day), 51.
Quite restless through the night (seventh night), 51.
Very restless, moving from side to side, throwing the arms about the head, but no position seemed to afford relief (tenth day), 34a.
Restless (first, second, and third nights), 57.
A constant desire to change from side to side, 52. [720.]
Feeling of great debility (after six hours and a half, third day), 44a.
Great sense of fatigue (general), as from long-continued labor, with fulness in forehead, and tendency to ache, mostly right side, continuing through the afternoon (after five hours), 34.
Rather fatigued during the forenoon (second day), 38.
Sensation of general fatigue, with the headache (after four hours), 31a.
Disinclination to move (fourteenth day), 33.
General weariness of whole body; easily exhausted upon going upstairs; greatly exhausted after a stool (third day). Very weak, especially in groins, at 9 A.M.; some weakness of body, and easily exhausted, at 9 P.M. (fourth day). A little weak (fifth day). Easily exhausted (sixth day). General weakness and tired feeling; weakness after stool; great weakness of right side (eighth day). Great weakness and stupidity; feel as if I had been out carousing the night previous (or as those feel who do go out carousing at night), (ninth day). Some weakness, at 9 A.M.; tired feeling, at 10 P.M. (tenth day). Easily exhausted (eleventh day). Some exhaustion on walking (twelfth day), 50.
Great deal of weakness and torpor since taking the medicine (eighth day), 33.
A steady erect position was with difficulty retained while going through with the dumbbell exercises (after twenty minutes); muscular weakness still experienced (after two hours and ten minutes), 3.
For the rest of the forenoon I felt too weak to leave my bed (five hours after 12 grains), 1.
Felt stupid and giddy as she walked along the street, with a sensation of a great feebleness over the whole body, rendering progression a matter of difficulty, 7. [730.]
Much weakness and leucorrhœa, at 4 P.M. (eighth day), 33.
Sense of weakness, extending from the head downwards through the back and legs, attended in the legs by the thrilling sensation heretofore described; slight exertion caused lameness and weakness in small of back (after three hours), 30.
During the forepart of the day (which was sultry) he had at times a feeling of weakness, though there was uncommon mental activity (second day), 30.
On walking became excessively tired; could hardly get along (fourth day), 54.
Muscular weakness on going upstairs (third day), 43.
Muscular weakness (after ten minutes), 4.
I tried to raise myself on my elbow to vomit, but failed; I made a second, more vigorous, effort, but scarcely moved; at once it struck me, "This is not debility, but volition is inoperative;" in a third effort I was more nearly successful, and in the fourth, a resolute exercise of the will, I did succeed, but could not vomit; the abdominal muscles acted too feebly, nor were they much aided by a voluntary effort to make them act (after 12 grains), 1.
Felt very languid and dull (second day), 54.
Feeling a languid, at 1 P.M. (second day), 42.
General languor (ninth day), 50 ; (8 A.M., sixth day), 71 ; (9 A.M., third day), 71b. [740.]
Very marked sensation of languor and indisposition to move, but by an effort of will my muscles were as fully under my control as before, 21.
General lassitude and dizziness; had to stop reading, 4.
Some lassitude (third day), 43.
Her whole frame seemed lessened and powerless (second day), 25.
Complete muscular relaxation, with continued fibrillar twitchings of the muscles, 18.
Quite prostrated, 14.
Very prostrate and pale (forty minutes after 12 grains), 1.
Appeared to be perfectly prostrated, 12.
Great prostration of muscular system ; feel as if I had taken a five-mile walk (after one hour and a quarter); still have this same feeling of prostration, with some headache, at 12 M.; prostration not so marked, at 10 P.M. (second day); prostration and headache light, at 12 M. (third day), 53.
Prostrated; felt severely indisposed; had to lie down and wanted the doors to be shut (third day), 41. [750.]
Complete relaxation of the whole body, as if every nerve were unstrung, even to the eyes, which felt as if all power to see were going out of them, at 6.30 P.M. (eighth day), 33.
Great feeling of prostration, nervous, tremulous, especially felt in the left arm, at 7 P.M. (third day), 71c.
General feeling of prostration, at 8 P.M. (fourth day), 71a.
Felt completely prostrated and obliged to lie down, at 10 A.M.; only wanted to be let alone, be well covered with woollen blankets, shut my eyes, and doze away the time, at noon (third day). All I wish is to rest and sleep, if the gripes would only allow it (fourth day). As the day wore on a general prostration set in again, as if my feet were too weak to hold me up; reading was tiresome, and speaking an effort; I tried to walk out, but had to five up on account of general prostration and soreness of bowels, produced by the motion (sixth day), 38.
Extreme faintness, not, however, unpleasant (forty minutes after 12 grains), 1.
Faintness with the dizziness (fourteenth day), 33.
Attacks of faintness (after a quarter of an hour), 18.
Sensation of faintness, with the trembling of the nerves at the pit of the stomach (fifth day), 33.
Great aversion to usual cold bath (third day), 68.
Very great reluctance to take my accustomed bath; felt uncomfortable after bathing; did not enjoy the bath (second day), 67. [760.]
Am in the habit of taking a cold sponge bath every morning, but I feel a perfect horror for cold water , and therefore omit it (fourth day), 38.
I have noticed that both days I felt the weakness have been particularly cool and bracing, 33.
General sensitiveness to cold, or change of temperature, with the headache (after four hours), 34.
Excessively nervous; cannot endure pain; especially sensitive during the filling of a tooth (eighth day), 44.
Felt sickish (after a very few minutes), 7.
Felt sick, and lay down in bed (after two hours and twenty minutes), 1.
Complained of sickness (second day), 12, 13.
Felt uncomfortable (second morning), 1.
On walking, noticed some two or three times during the day, on raising my foot, a momentary feeling as though I was going up, floating-like, and on foot touching ground and unpleasant feeling that made me feel a shuddering sensation pass over me, 52.
Confused feeling, dull, stupid, sluggish, at 8 A.M. (third day), 71a. [770.]
Dull and sluggish (fourth day), 71b.
Dull and sluggish throughout the day (after two days), 71d.
Feel dull and languid (second day), 54.
Just before 6.30 P.M. I felt a sudden access of vigor, and felt particularly strong, and the symptoms which followed seemed to come like a reaction (eighth day), 33.
Feels as if he had taken a cold (second day), 41.
Feel sore and stiff all over; feel as if I had taken a severe cold (second day), 36.
A kind of paralyzed feeling in the left side throughout (after fourteen hours and a half), 36a.
Intense suffering, producing perspiration on forehead (tenth day), 34.
Pains, which are of a darting character, wander from one place to another (fourth day), 58.
Darting pains in various parts of the head, aggravated by motion (after eight hours and a half), 36a. [780.]
Slight momentary pains in various parts of the body, as twinging pain in the fingers of the left hand (after a few minutes), 28.
Various twinging pains about the body (after half an hour), 26.
Occasionally sharp pain in different parts of the body, head, limbs, knees, and elbows (fifth day), 23a.
The severity of the pains frightened her, and she declined to continue the proving, 35.
(Felt the customary stitches in the left side), (after half an hour, second day), 27.
(All old ailments returned with renewed force), (sixth day), 67.
Nervous motions go not only down through the body, but through the arms, and it seems as if a little stronger dose would make the arms move; this time the motions were accompanied with violent palpitation of the heart, at 3 P.M. (fourteenth day); with much weakness at the pit of the stomach (fifteenth day), 33.
A strange indescribable sensation throughout the system, continuing many days (after half an hour), 25.
For two weeks after taking the last dose had frequent recurrence of the head, throat, hip, and knee-joint, symptoms, growing gradually less frequent and severe, 71.
All the forenoon I was engaged in packing in camphor-chest; I was in the midst of crude camphor, which suspended the symptoms entirely for the time; but very soon afterwards, in less than an hour, they returned (fourth day), 33. [790.]
In the first action of the medicine, all the symptoms run through two days, with one exception, that of soreness in the tongue and difficulty of moving it; the medicine has begun a second round or course, which has been much longer (third day). All the symptoms are more decided, distinct, and prolonged than the first time, and the medicine seems to act more searchingly than in the first round, although the dose has not been repeated (fifth day), 33.
The symptoms continued without abatement for about sixteen hours, notwithstanding several remedies had been tried; at length the fact that the pain seemed to be produced by hard pressure on the lower end of the sternum, led to the selection of

Arnica 30 , which afforded prompt and decided relief, 34a.

The chief action of this medicine seems to me to be in the nerves; all the other symptoms have been entirely accessory and secondary; and it seems to me, so far as I can judge, to have a very curious double action on the nervous system; the nerves in front of the body (which I believe are the ?? voluntary nerves, or ?? nerves of motion), it appears to excite to involuntary motion, causing tremblings, and going up and down in wavelike motion, all down through; but the nerves in the back of the body (the ?? passive nerves or nerves of ?? sensation), it seems to paralyze and numb, and during this numbing process it causes a good deal of pain, very similar to a pain in a tooth when its nerve is dying or being killed, 33.
The medicine seemed to act more on the left side than on the other, 33.
I think the medicine hinders voluntary motion as well as causes involuntary motion, 33.
Better in warm room, from not moving, 65.
Walking seemed to relieve the pains, but I had not strength to continue any length of time (second day), 58.
Worse from motion, better in the open air (after two hours and a half), 36a.
State very like the effects of an overdose of Aconite (after 12 grains), 1.
Symptoms wore off gradually in two or three days (after six days), 66.

SKIN. [800.]

Eruption upon the back about the size of fleabites; the same petechial eruption on the arms (fourth day), 56.
Fever blisters in and around left nostril (seventh day), 67.
Applied to the skin it benumbs, and causes a pricking all over the spot, 6.
Itching of the left palm (fourth day), 23a.

SLEEP

Sleepiness.
Yawning (second day), 58.
Continual yawning, with a drowsy feeling all day (second day), 60.
For three or four days I felt irrepressible drowsiness, especially from early morning till 2 P.M.; this continued for a week. The drowsiness was diminishing (after two weeks), 27.
In the worst cases there was great drowsiness, while others complained of giddiness, 14.
Became drowsy, and slept for two hours, but the mind was so active all the while that I was not conscious of having been asleep (two hours after 12 grains), 1.
Drowsy at 11.30 A.M.; lay down and slept in afternoon (which I am not accustomed to); dreamt my head was full, and as if brain was revolving upwards from frontal sinus to occiput, and that I was almost blind (fifth day); drowsy, at 9 A.M. (sixth day), 37. [810.]
Sleepy (second day), 41.
Irresistible desire to sleep; soporific sleep , extremely distressing, with the headache (second day); felt drowsiness and desire to sleep all the forenoon, even while driving; after dinner the drowsiness, instead of passing off by exercise, increased, and for two hours he slept soundly, without dreams, in an uncomfortable position; he could arouse himself only with great effort; the sleepiness continued for an hour, even while walking in clear, cool air and bright sunlight; slept well all night (this is never the case after having even a short nap in the afternoon), (third day). He awoke at 6 A.M., and felt bright for two hours, when he became sleepy again while driving, with dull pressure encircling the head; after a light dinner, sleepiness became irresistible, and he slept some time; went to bed early and slept well (third day); drowsiness all the day, until after two hours' work in the garden, causing profuse perspiration, which expelled the drowsiness in part (fourth day); felt it slightly (fifth day), 26.
Felt sleepiness while riding, for two mornings; after dinner he felt great drowsiness, which was very difficult to shake off; his desire for sleep was uncontrollable; he would fall asleep so quickly that he was surprised on waking up that he had slept; a few hours of hard exercise would remove the drowsiness; he slept just as well at night as if he had not slept in the afternoon, 26b.
Such sleepiness that the attempt to keep awake produced nausea, with the headache, 66.
Intense sleepiness, which I thought came from the medicine (sixth day), 33.
I am not usually a heavy sleeper, but was intensely sleepy in the morning; almost impossible to get myself up, as if drugged (sixteenth day), 33.
I went to bed an hour and a half earlier than usual; was so sleepy I could not keep my eyes open; slept till after daylight, an hour later than I usually do (first night), 46b.
Very sleepy at 3 P.M., hardly able to keep awake, till finally relieved by sleep (after five hours, third day), 62.
Heavy sleep; feel tired before rising; profound sleep; does not see why he should sleep so soundly, 65.
(Slept better than for six months before (first night); slept very soundly (second night); slept unusually well (third night); curative? C. W.), 61. [820.]
During the proving I awoke every morning to hear the clock strike 2, and generally fell asleep after 5, 43.
Sleeplessness and Dreams.
Sleeplessness before midnight; disturbed sleep after (second night), 68.
(In the evening I was no drowsy as usual, but wakeful), (first day), 28.
Falling asleep frequently, but always awoke suddenly, without relief; the following night scarcely closed the eyes in sleep; thoughts very active; an idea started, kept on with unusual persistence (tenth day), 34a.
Sleep rather restless (first night); slept restless the whole night (sixth night), 38.
Sleep disturbed; wide awake about 2 A.M., and remained awake till about 5, then a very deep, short sleep of about an hour; on awaking a very disagreeable feeling, as though I had slept too sound, with pain on right side of head and right side of neck, 52.
Conscious of having remained awake for some time in a dreamy state (first night), 5.
Vivid, pleasant dreams, 65.
He dreamed that he was a lion, 24.
Sleep was disturbed by lascivious dreams, and by emissions early in the morning, 64. [830.]
Horrid dreams all night (fourth day), 45.

FEVER

Chilliness.
Very cold, 14.
Chills in paroxysms (second day), 33.
Felt chilly, in the evening (first day), 31.
The heat of the bed was agreeable, as I could not throw off the sensation of chilliness which followed me the whole day (third day), 38.
Chilly creeps passing up the back, with the slight nausea, at 2 P.M. (fifth day), 71b.
Chilly sensation in my back, soon commenced to yawn and have bad feelings, a sort of bruised feeling in my joints; every draft of air seemed to make me shudder; every time I moved the same bad feeling come upon me (second day), 58.
Chilly on the right side of the back, at noon (second day), 60.
My limbs become chilly, with a vague feeling of discomfort; but warmth to the feet relieved this, and a sinapism over the whole abdomen was peculiarly grateful when it began to act (after 12 grains), 1.
Feverish, with chilly creeps up the back (fourth day), 71a. [840.]
Hands are cold, then hot and red, 65.
Feel cold all the time (after nine hours and a quarter), 36.
Cold and clammy skin, 14.
Heat.
Slight chills and fever, with the violent frontal headache, at 8 P.M. (third day); with hot and dry skin, at 10 A.M.; symptoms constantly growing worse, at noon (fourth day), 71a.
Temperature about 100 (second day), 38.
Feverish, at 2 P.M. (third day), 71a.
Dry heat all over, with the uneasiness and distress about the heart, 43.
Much heat in head and face, with heavy headache and pain in eyes, at 2 P.M. (tenth day), 33.
Heat hot and throbbing in temples, at 2 P.M. (third day), 71a.
Forehead hot and feverish, at 2 P.M. (fifth day), 71b. [850.]
Face hot, flushed, and suffused, together with a feeling as if a change into a lower temperature would produce chill, continuing through the afternoon (after five hours), 34.
Sensation of heat in face and down the back, as when the sun shines directly upon you on a cold day, while lower extremities were rather chilly, in the evening (second day), 66.
Hot cheeks (after seven hours and a half second day), 62.
Dry heat in the hands (first night), 43.
Paroxysms of burning in palms of hands (third day), 61.
Sweat.
Profuse sweat on the least exertion (after three hours and three-quarters, second day), 49a.
Perspire very easily, 65.
Perspiration over the whole body, on waking in the morning, brought on by any excitement during the day (second day), 49.
Cold sweat in drops over the whole body, after the vomiting, 18.
A little perspiration, with the head symptoms (after sixty-five minutes); copious perspiration all over the body (after seventy-five minutes), 2. [860.]
Strong-smelling sweat around the genitals; prepuce tender and swollen, with some eruption on the glans penis, which was easily excited, with a burning-itching sensation (these all disappeared in about forty-eight hours), (fourth day), 38.
Slight perspiration over the body, with the headache (second day), 54.
Skin moist, at 8 P.M. (fourth day), 71a.

CONDITIONS

Aggravation.
( Toward morning ), Very restless.
( Morning ), Early, symptoms, 71 ; exhilarated; headache, with epistaxis; constriction around top of head; 9 A.M., pain in forehead; before rising, dull headache in forehead; on awaking, dull frontal headache; early, lateral headache; eye symptoms, with burning of the balls; 7 A.M., on rising, darting pains in both eyes; mydriasis; itching of left nostril, with moisture; tired look; teeth felt rough; on waking, taste in mouth like creosote; bad taste; on waking, nausea; pain in region of liver; 4 A.M., on rising, soreness in left side of abdomen; uneasiness in bowels; 4 A.M., griping pain in bowels; 7.30 A.M., before stool, pain in abdomen; offensive breath; pain in left of sacrum; 7 A.M., shooting pain in left shoulder; 7.30 A.M., trembling of the hands; 8 A.M., confused feeling; early, till 2 P.M., drowsiness; while riding, drowsiness, sleepiness; early, sleep disturbed by lascivious dreams; on waking, perspiration over whole body.
( Forenoon ), 8 A.M., dull heavy feeling in head; 8 and 10 A.M., dull headache; 8 A.M., heavy headache; congestive headache; while walking, pain in head, with dizziness; 10.15 A.M., headache in left frontal region; 10 A.M., heavy frontal headache; 11 A.M., while in church, aching in temporal region; shooting pains through right side of head; 11 A.M. to 8 P.M., drawing-twisting sensation in eyes; eyes bloodshot and burning; 11 A.M. to 8 P.M., partial deafness; 9.30 A.M., pricking sensation in stomach; sharp pains in stomach; 10.30 A.M., soreness at pit of stomach; 9.50 A.M., pain in left hypochondrium, thigh, and forearm; 10.25 A.M., pain in region of liver; 10 A.M., griping pain in transverse colon; 8.10 A.M., diarrhœic stool, with burning at the anus; secretion of urine; with difficult retention; erections, without sexual desire; in fresh bracing air, choking sensation, with fluttering of the heart; 11 A.M., burning-throbbing sensation in left arm and hand; pain in left wrist; 11.30 A.M., numbed sensation in hands; 9 A.M., pain in lower limbs; weakness in right knee; gnawing sensation in left tibia; 9.30 A.M., trembling all over; 10.30 A.M., trembling of the hands; 9 and 11.30 A.M., drowsy; 10 A.M., dry, hot skin.
( Toward noon ), Gloomy.
( Noon ), Nausea in throat; chilly on right side of back; all symptoms.
( Afternoon ), 4.30 P.M., vertigo and nausea; 1 P.M., on moving, dizziness; till 10 P.M., pain in head; headache; 5 P.M., headache; 2 P.M., headache and pain in eyes; 1 P.M., pain in forehead; 4 P.M., on motion, exercise, or mental exertion frontal headache; pain over right eye; 3 P.M., aching pain over left eye; 2 P.M., headache over right eye; 4 to 10 P.M., headache, with qualmishness; 1 P.M., headache over left eye; 2 P.M., dull frontal headache; 5 and 8 P.M., weight over eyes; 4 P.M., pain through temples, with throbbing of the arteries of the side of the neck; numbness of the temples and crawling sensation over the head; 1 P.M., headache in temporal region, with sleepiness; 2 P.M., eyes dull and heavy; 3 P.M., drawing-twisting sensation in eyes; 4 P.M., twitching of upper lids; 3 P.M., shooting pain in left ear; 2 and 8 P.M., sensation as if nose were going to bleed; itching of left nostril; with dryness; 4 P.M., tongue sore on tip and rough; 6 P.M., collection of mucus in throat; 2 P.M., soreness in throat; 4 to 10 P.M., throat sore, studded with ulcers; 3 P.M., when swallowing, pain extending from throat to left ear; thirst; 4 P.M., eructations; 5 to 8 P.M., hiccough; 3 P.M., sense of emptiness and weakness in stomach; 6 P.M., soreness in the umbilicus; 3 P.M., looseness in bowels; pain in abdomen; 4.30 P.M., cutting pain in abdomen; 5.50 P.M., bowels feel uneasy; 6 P.M., pain in groin; 2 P.M., pain extending from left hip into groin; 3 P.M., sensation of fulness and distension of the bladder; urine high-colored and smelling strong; 4 P.M., leucorrhœa and weakness; 6 P.M., dry cough; 5 P.M., sticking pain in apex of right lung; 6 P.M., soreness around the body, at the waist; 3.45 P.M., pains beneath clavicle; pain at base of brain; 2 P.M., pain in back; 1 P.M., stiffness and pain down spine; while sitting, pain under right shoulder-blade; 6.30 P.M., pain in back, between hips; pain in left of sacrum, 5 P.M., numbness of left forearm, with pain; pain; pain in right wrist; 2 P.M., pain in right knuckles; 6.30 P.M., weakness of legs; 6 P.M., left hip and right knee stiff; when walking, stiffness in both rectifemoris muscles; 6.30 P.M., sensation as of a drawing of cords behind leg and knee; 2 and 6 P.M., gnawing sensation in left tibia; sense of fatigue; 4 P.M., weakness and leucorrhœa; 1 P.M., languid feeling; just before 6.30 P.M., sudden access of vigor; nervous motions through body, with palpitation of the heart; 3 P.M., sleepy; 2 P.M., chilly creepings up back, with nausea; feverish; heat in head; face hot and flushed.
( Toward evening ), Headache.
( Evening ), 7 P.M., all symptoms, 50, 71 ; in passing people, dizziness; 7 P.M., head feels stupefied; headache; 7 and 8 P.M., headache; 8 P.M., frontal headache; dull frontal headache; 6 P.M., drawing sensation in eyes; eyes sore and painful when moved; 61/2 to 10 P.M., pain in right eyeball; 10 to 12 P.M., pain in right supraorbital ridge; 7 P.M., on studying, darting pain in left eye and superciliary ridge; pain and stitches of ball of right eye; 7 P.M., twisted sensation in right eyeball; 8 P.M., twisted sensation in the eyeballs; uncomfortable sensation in right ear; 6.45 P.M., sharp shooting pain in right ear; 7 P.M., buzzing and ringing ear; hammering in right ear; external ear felt as through hot air were blowing on it; 9 P.M., partial deafness in right ear; itching of left nostril, with moisture; 8 P.M., twitching of the mouth and eyebrows, etc.; 9 P.M., roof of mouth feels as if covered with patches of loose skin, and has a yellowish appearance; metallic taste in mouth; swallowing of saliva painful; throat sore; tonsils and soft palate inflamed; 7 and 8 P.M., throat sore; 10 P.M., throat dry; when swallowing, constricted feeling of throat; 9 P.M., scrapy burning sensation in throat; desire for cold water; 7 P.M., empty eructations, 8.30 P.M., hiccough; 9 to 11 P.M., hiccough; 10 P.M., nausea; rumbling in bowels; 8.40 to 11 P.M., rumbling and gurgling, with heat, in abdomen; 8.30 P.M., rattling in abdomen; colicky pains low down in abdomen; 8 P.M., pain in groin, with swelling; 7 P.M., pain in groin; profuse urine; highly colored and strong-smelling; 10 P.M., dyspnœa; 7 P.M., pain in right side; chilly creeping sensation passing up back; 8 and 9 P.M., numbness over back of head and down spine; 8 P.M., pain in left shoulder; 7 P.M., numbness in left arm and ring finger; 8 P.M., pain in muscles of right forearm; 8 P.M., pain in left wrist; while in warm room, cramp in left foot; 10 P.M., restless in bed; chilly; 8 P.M., chills, with frontal headache; heat in face and back; 8 P.M., skin moist.
( Night ), Dizziness; constriction around top of head; 3 A.M., pressive headache; aching of eyelids and inner canthus of right eye; after lying down, singing; 2 A.M., awakened by pressive pain in epigastrium; on awaking, hiccough; pain in region of arch of colon; pain in right deltoid muscle; uneasiness and distress about heart; woke with rapid tumultuous action of the heart; after 3 A.M., dragging pain over left hip; dart of pain through right thumb; restless sleep; horrid dreams.
( Before midnight ), Sleeplessness.
( Midnight ), Palpitation of the heart, with throbbing over the body.
( After midnight ), Disturbed sleep.
( Going into open air ), Headache.
( Mental activity ), Symptoms.
( Bending forward or throwing shoulders forward ), Headache.
( Closing lids ), Sensation as if they were too tight.
( Cold or change of temperature ), Sensitiveness, with headache.
( After dinner ), On going out of doors, pain in stomach; heavy pain in back, under left shoulder; sound sleep; great drowsiness.
( After drinking new milk ), Headache.
( While driving ), Sleepiness, with dull pressure encircling head.
( Exercise ), Symptoms, 50.
( Exertion ), Profuse sweat.
( During expiration ), Stitches under interior angle of scapula.
( Feeling of pulse ), Benumbed sensation in hands.
( Flexing knees ), Pain in part.
( On going up and down stairs ), Stumbling.
( Going upstairs ), Exhaustion; muscular weakness.
( Going downstairs ), Pain in patellæ of both knees.
( When looking at an object ), Bright marks.
( On lying down ), Nausea.
( Lying down ), Headache.
( Lying on back ), Griping in abdomen in right iliac region.
( Lying on left side ), Pain in right iliac region.
( Making heavy or misstep ), Pain in head.
( Motion ), Heavy feeling in head and pains through temples; pain in head; pain in frontal and temporal regions; darting pain in temporal region; griping pain in upper abdomen; pain in sacral region; all symptoms.
( After micturating ), Pain in the urethra.
( Noise ), Lateral headache.
( Pressure ), Epigastric region sore.
( Reading ), Pain in posterior part of orbit.
( When reading ), Dark-yellow spots on book.
( While riding in carriage ), Lateral headache.
( Riding ) Soreness in left side of abdomen.
( Before rising ), Tired feeling.
( Rising up ), Shooting pain through right side of head.
( Rising from sitting position ), Pain and flushing of the face.
( Sitting down ), Paroxysms of muscular twitchings in vastus externus muscle.
( While sitting ), Still, pulsation felt through whole body; pulse very painful; numb pain in knees and ankles.
( Sound of organ ), Headache in temporal region; nausea.
( Standing erect ), Pain in bowels.
( Before stool ), Griping pains.
( Before and after stool ), Tenesmus.
( After stool ), Exhaustion.
( With stool ), Burning at the anus.
( While at supper ), Epistaxis, right side, with headache.
( When swallowing ), Soreness of throat; throat painful.
( While taking morning cold bath ), Stiffness in right side of neck.
( Traveling in cars ), Headache, sleepiness, etc.
( Turning head ), Headache.
( After vomiting ), Cold sweat over whole body.
( On waking ), Headache; stitches in left breast; from midday nap, brain felt confused.
( Walking ), Dizziness; headache; shooting pains through right side of head; vision hazy or misty; piles painful; on raising foot, floating-like feeling; on foot touching ground, shuddering sensation; unsteadiness from knees downwards; pain in left thigh and both knees; stupid giddy feeling, with sensation of feebleness; became very tired.
( Walking downstairs ), Dizziness and dimness of vision.
( Walking in open air ), Headache.
( While writing ), Pain in right ear.
Amelioration.
( Morning ), Headache.
( Evening ), 10 P.M., pain in head.
( Open air ), All symptoms.
( Open air and while lying down ), Symptoms, 71.
( Mental application ), Headache.
( Close attention to a sermon ), Headache.
( Closing eyes ), Symptoms, 50.
( While in midst of crude camphor ), All symptoms.
( Eating ), Lateral headache; pain in right iliac region.
( Hard exercise ), Drowsiness.
( Exertion of will ), Unsteadiness from knees downwards.
( Going out ), Symptoms, 49.
( Leaning head toward right side ), Pain in clavicle.
( Lying on right side ), Gripings bowels.
( Motion out of doors ), Pain in forehead and eyes.
( Moving about ), Pain in eyes.
( Violent motion ), Pain in right deltoid muscle.
( Continued motion ), Pain in left popliteal space.
( Outdoors and walking ), Symptoms, 63.
( Pressure ), Pain in right iliac region; pain in upper part of lung.
( Pressing on eyes ), Pain in right eyeball; pain in eyes.
( Keeping quiet ), Symptoms, 50.
( On retiring ), Hiccough.
( After rising ), Headache.
( Sitting up in bed ), Pain in top and forepart of head.
( Sleep ), Hiccough.
( In warm room ), All symptoms.
( Walking ), Pains; in open air, pain in right iliac region.

Physostigma