Croton tiglium, Linn. (Tiglium officinale, Klotzch).

Natural order , Euphorbiaceæ.

Common names of seeds , Croton oil seeds, Puergirkörner, Piñones de Maluco, Grames de Tilley, Petit Pignon d'Inde.

Preparation , Tincture of the oil from the seeds.

Authorities.

1 , Hermann, Praktische Mitt. (from Roth's Mat. Med.); 2 , a girl, aged 25, took one drop on sugar, from Buchner's collection, Archiv. f. Hom. Heil, 19, 116; 3 , effects of one drop on a young, black-haired girl, ibid.; 4 , effects of three drops on a girl, aged 26, with carious teeth, ibid.; 5 , effects of three drops on another girl, ibid.; 6 , effects of three drops on a girl of 36 (taken for urticaria), ibid.; 7 , effects of three drops triturated with sugar, and taken in three doses, on a girl aged 26, ibid.; 8 , effect of three drops on a student, aged 23, ibid.; 9 , a girl, aged 20, took one-eighth of a drop daily, afterward three-eighths, afterward one-half, and again three-fourths of a drop daily, ibid.; 10 , a man, aged 32, took one drop on sugar, ibid.; 11 , Dr. S. T., aged 26, took repeated doses of three-tenths, one-half, three-fourths of a drop, and one drop, ibid.; 12 , a girl, aged 32, took one-half a drop for several days, afterward three-fourths of a drop, ibid.; 13 , K. M., aged 26, effects of smelling a solution of two drops to 100 of Al., afterward of the pure oil, and of taking two or three drop doses, ibid.; 14 , B., a man, aged 27, took numerous doses of from one-tenth to one drop each, during a period of about seven weeks, ibid.; 15 , effects on a girl of 15 of rubbing five drops on the arm, ibid.; 16 , Commensur. Jour. d. Pharm., 13, p. 394, effects of getting some into the eye, ibid.; 17 , Tavernier, Froriep's Notizen, 12, p. 287, rubbed some oil about the umbilicus, ibid.; 18 , C. M., rubbed some oil over the left deltoid muscle, and afterward a little below the same place, ibid.; 19 , the same, effects of the fumes inhaled while rubbing the oil into the arm; 20 , the same, effects of rubbing oil above the umbilicus; 21 , Dr. Joret, effects of one or two drops taken internally (Archiv. Gén. de Méd., 1833), A. H. Z., 4, p. 69; 22 , A. H. Z. Mon. Bl., 9, p. 62, a man drank some by mistake, taking about half an ounce; 23 , Rumph, effects of the whole plant, especially of the leaves, Herb. Amboin, t. 4, p. 98, from Wibmer; 24 , Buchner, effects of chewing and spitting out a seed, Toxicologie, 1827, from Wibmer; 25 , Wibmer, effects of one drop made into two pills, taken with an interval of half an hour; 26 , Landsberg, effects of half a large seed, Pharmacog. Euphorb. Diss. Berol., 1831, from Wibmer; 27 , same, effects of one drop on sugar; 28 , same, effects of rubbing oil into the abdomen; 29 , Hencke, effects of rubbing oil into umbilical region, Archiv. f. Hom. 20, 2, 183; 30 , same, proving with 2d trit. of seeds; 31 , Dr. Brentzer, proving with 15th dil., ibid.; 32 , same, provings with 4th dil.; 33 , Connell, general effects, from Buchner's collection, Archiv. Hom., 19, 1, 119; 34 , Piedagnel, general effects, ibid.; 35 , Meinel, effects of rubbing oil into inguinal region, Fr. Mag., 4, 966 (from Deutsch Kl., 1851); 36 , Guttseit, effect of two drops, repeated after two days, for obstinate constipation, Fr. Mag., 4, 274 (from Med. Zeit., 1846); 37 , Græfe and Walther, effects of one drop, Fr. Mag., 1, 592 (Rust's Mag., 1836); 38 , Hutchinson, general effects of rubbing in six drops on the skin, Bost. Med. and Surg. Jour., 8, 411; 39 , effects of two drops, taken for scanty menstruation, from the last; 40 , Pereira, effects of the dust encountered while emptying packages of the seeds, Mat. Med., 2, 1, 606; 41 , Prujer, Rust's Mag., 19, 3, 525, from Roth's collection (Mat. Med.); 42 , Koehler, Rust's Mag., 46, p. 45, ibid.; 43 , Romberg, Casp. Wochen., 1835, ibid.; 44 , Brandes, Hufel. Journ., 57, p. 120, ibid.; 45 , omitted; 46 , Horn's Archiv., 60, p. 574, ibid.; 47 , Murray, App. Med., 4, 150, ibid.; 48 , Cohansen, Act. nat. cur., 9, p. 39, ibid.; 49 , Boudet, Abeille Méd., 1845, ibid.; 50 , Vautherin, effects of inunction of stomach with twelve drops, Monograph des Graines de Crot. Tig., Paris, 1864; 51 , Med.-Chir. Rev., July, 1834 (All. Med. Zeit.), general effects of external use; 52 , Mayet and Hallé, poisoning of three persons by strawberries impregnated with the oil, Ann. d'Hyg., 35, 193; 53 , Maurezin, poisoning of a girl of 6 years by three grammes in "café au lait," Gaz. des Hôp, June, 1868; 54 , omitted; 55 , C. C. Shayer, general account of poisoning of five persons by eating some birds over which some Crot. oil had been spilled, Am. J. of Med. Sei., Jan., 1867 (the birds had been well washed previous to cooking); 56 , Tilbury Fox, general effects of inunction, Lancet, April, 1867; 57 , S. R. Percy, general effects of internal and external use, Am. Med. Times, 55, 170; 58 , Brydone, effects of a teaspoonful of a mixture of equal parts of Croton and olive oil, Ed. Med. Jour., 1861; 59 , J. L. Bunting, poisoning of a woman by one ounce, Med. Record, 3, 274 (Boston Med. and Surg. Jour.); 60 , Keith, effects of a teaspoonful on a boy, given by mistake in hooping-cough (Ed. Med. Jour), from Br. J. of Hom., 2, 129; 61 , Berridge, proving on a man with several doses of the 200th dil., Lehrmann (A. J. of H. M. M., 1874, p. 128); 62 , Marchand, proving on self with two pills of Croton oil taken in bread, "Du Croton Tiglium," Paris, 1861; 63 , Vautherin, effects of eight or ten drops taken by mistake with food, "Des Graines de Croton Tiglium," Paris, 1864, p. 88.

MIND

Emotional.
Disinclined to speak; uttering no complaints (after three hours), 60.
Sadness, 9.
Great depression of spirits, 12.
Anxiety, 13.
Great anxiety, 13 ; (after one hour), 55.
A peculiar feeling of anxiety, as though some misfortune were about to happen, 32.
Solicitous mood, 32.
Fretful, 32.
Peevishness and fretfulness; everything is unpleasant to him, 14. [10.]
Morose mood, 19.
He is very morose and dissatisfied, 14.
Intellectual.
He has no inclination to work; would much rather dance than attend to his business, 14.
Thought difficult, 32.
Loss of memory, 14.

HEAD

Confusion and Vertigo.
Confusion of the head, 8, 31.
Confusion in the head, especially in the temples, 14.
Confusion of the head, immediately on rising, 14.
Confusion of the head, with dulness and pressure in the forehead, 13.
Confusion of the head, but especially of the frontal region, with pressure and heaviness, 13. [20.]
Confusion of the head, especially on the right side, with pressure downward from the vertex, so that there is sometimes sticking extending downward below the ear, with impaired hearing in the right ear, 14.
Confusion of the whole head, lasting through the night, 13.
Confusion of the whole head, on going into the open air, 13.
Great confusion of the head with the vomiting, which also lasted three days, with loss of appetite, 11.
Great confusion of the whole head, with pressure towards the frontal region, and nausea, 19.
Head very much confused, 18.
Confusion of the forepart of the head, especially of the frontal region, 18.
Confusion of the forehead, 13, 14.
Confusion of the left half of the occiput, 14.
Confusion of the occiput, 14. [30.]
Vertigo, 9.
Vertigo, so that she could scarcely remain sitting, especially on looking up, 9.
Vertigo and confusion of the head, lasting all the afternoon, 14.
Vertigo, especially on the right side, with pressure in the right eye, 14.
Vertigo, with nausea, so that she was obliged to go into the open air, where she became worse, looked pale, seemed very weak and exhausted, 5.
Attacks of vertigo, while walking in the open air, 14.
Head felt dizzy, 13.
Dizziness of the forehead, 19.
He became very giddy and fell down insensible, 40.
General Head.
Head feels as after intoxicating drinks, 14. [40.]
Heaviness of the head (in half an hour), 1.
Heaviness and confusion of the whole head, with prickling in the eyes, 14.
Head heavy, dull, and confused, in the morning, on waking, 13.
Pains in the head, especially worse in the middle of the day, and particularly for a few hours after dinner, 13.
Headache, day and night, for three days, affecting the anterior and upper part of head; it is dull, continuous, and very confusing; not affected by rest or work, 61.
Headache, as from disordered stomach, 32.
Headache, with confusion, followed by general heat and copious sweat, 34.
Violent headache, 36.
Burning pain in the head, 40.
Feeling of fulness of the head, 13. [50.]
Head full and confused, with heaviness of the forehead, 13.
Head very full and heavy, so that she was unable to read, 2.
Congestion seems to rise from the abdomen to the head, with warmth of the skin and sweat, 13.
Sticking headache, extending to the vertex (second day), 12.
Sticking twitching in the head, 14.
Sensitiveness of the head; the weight of his hat gives him a headache when out walking (which had not happened previously). When he took off his hat, the headache stopped (in an hour and a half), 1.
Jerkings in the head, 13.
Forehead.
Pain in the forehead, with tearing extending to the right temple, where it remains for two hours as a sticking pain, 12.
Slight pain in the forehead, relieved after keeping quiet for half an hour, 31.
Violent pains in the forehead, with throbbing tension and pressure outwards, and general confusion of the head, aggravated by taking some beer and bread, 13. [60.]
Fulness and pressure in the frontal region, 13.
Tensive pain in the forehead, with pressure and sticking, 13.
Pressure in the forehead, 14.
Pressure in the right side of the forehead and temporal region, 19.
Pressive pain in the left half of the forehead, 14.
Sticking in the forehead, while walking, 14.
Temples.
Pain in the left temporal region, as if burnt with hot coals, 11.
Pressure in the temples, 14.
Sticking in the left temple, 14.
Twinging pain in the temples, 14.
Vertex. [70.]
Tearing in the head, towards the vertex, 10.
Sides.
Sticking, as from needles, in the right side of the brain, above the eye, 12.
Occiput.
Pressive headache in the occiput, 11.
External Head.
Prickling in the scalp on the vertex, 14.
Crawling in the occiput, 14.

EYE

Objective.
Eyes quite bright, peculiar at times, 59.
Violent inflammation of one eye, 16.
Violent ophthalmia and inflammation of penis and scrotum, in consequence of inadvertently carrying the fingers (after applying the drug) to the eyes and genital organs (two cases), 51.
Subjective.
Heaviness, weakness of the eyes, 19.
Violent pains in the eye (local effect), 16. [80.]
Violent pains, followed by swelling of the whole eye and side of the face (from some of the oil getting into the eye), 16.
Sticking in the middle of the left eye, and afterwards some indications of it in the right, 14.
Orbit.
Slight tensive pain above the right orbit, with pressure in the right side of the occiput, 32.
Lids.
Violent twitching of the eyelids, 13.
Cramplike pain in the right eyelids, especially towards the external canthus, 14.
Jerking sticking in the right external canthus, with frequent contraction and twitching of the whole eye, 19.
Lachrymal Apparatus.
Running of water from the eyes and nose, 13.
Copious lachrymation, 40.
Conjunctiva.
Inflammatory redness of the conjunctiva of the left eye, 11.
Ball.
Sticking in the left eyeball, 14.
Pupil. [90.]
Pupils dilated, 40.
Vision.
Vision impaired, with staring, glittering eyes, 5.
Sight dim, as if there were smoke in the room, 9.
The sight vanishes easily, 19.
Sight vanishes easily, as though a veil were before the eyes, 13.
Vision vanishes in the room, with slight vertigo, 13.
Fog before the right eye, followed by weakness of it, 14.

EAR

Sticking beneath the left ear, 14.
Dragging and twisting sensation towards the orifices of both ears, 13.
Dull dragging pain towards the orifices of both ears, 13. [100.]
Twinging pain in the left ear, 14.
Spasmodic twinging pains deep within the left ear, 11.*
Hearing.
Roaring in the ears, 16.
Roaring in the ears, and a kind of vertigo; he was unable to stand from fear of falling, 16.
Hearing and sight disappeared with the nausea, 2.

NOSE

Objective.
Increased secretion from the mucous membrane of the nose (after smelling the oil), 14.
Coryza, with slight discharge from the nose, lasting some days, 10.
Coryza; with slight watery discharge, 13.
Subjective.
Dryness of the nose and throat, 11.
Burning in the right nostril, obliging him to rub it (in three hours and three-quarters), 1. [110.]
Burning sensation in the nose and mouth, 40.
Drawing pains, extending through the nose to the root, and thence into the brain, 19.
Constant irritation in the nose and in the conjunctiva of the eyes (from the fumes of the oil), 14.

FACE

Objective.
Countenance distressed, 40.
Face expressive of fatigue and debility, 63.
Countenance pale and rather shrunk (after three-quarters of an hour), 60.
Face pale, with sensation of coldness, 13.
Slight jaundice color, 36.
Face hands, and toes cyanotic, 22.
Swelling of the face and hands (from triturating the grains in a mortar), 41. [120.]
Swelling and redness of the face and eyelids, which are covered with small vesicles (from the effluvia), 44.
Subjective.
Increased warmth and burning in the right half of the face, starting from the corner of the mouth, 14.
An illusory sensation as though insects were creeping on the face, 32.
Lips.
Lips swell and become quite sore (external application), (1 or 2 drops), 57.
Lips dry, cracked, 11.
Lips dry and tense, in the evening, 14.
Burning in the angle of the mouth, with slight swelling on the outer border, lasting several days, 14.
Tension in the corner of the mouth, 14.

MOUTH

Teeth.
Drawing in the right lower eye-tooth, 14.
Sore pain in the left molar of the lower jaw on chewing, 14.
Gums. [130.]
Painful swelling of the gum of the inner side of the right upper jaw, 11.
Gum bleeds easily in the morning while washing, 14.
Tongue.
Tongue white, showing impress of teeth (one case), (after eighteen hours), 55.
Tongue coated white, 13, 26.
Tongue red, smooth, glistening, and dry in centre (second day), 60.
Tongue furred and dry (second day), 58.
An eruption plainly visible at the root of the tongue, on the soft palate, and on the posterior wall of the pharynx (third day), 54.
Swelling and numbness of the tongue, 40.
Burning and sensation of contraction at the tongue and pharynx (during twenty-four hours), 41.
Sensation of peppery heat, at first not very marked, but gradually increasing, successively felt on the palate, uvula, isthmus faucium, pharynx, tongue, and lips (after a few seconds), 63. [140.]
He stated that his tongue felt too large for his mouth, and appeared to be without feeling, and he had bitten it two or three times to ascertain whether there was any sensation in it. On examination, however, no change could be observed in the size or appearance of the tongue or parts about the mouth, 40.
Tickling painful sensation in the tip of the tongue, 13.
Feeling as though the tip of the tongue were electrically sensitive, with a sweetish bitter taste, 19.
General Mouth.
Inflammation of the mouth, lips, and pharynx, 23.
Swelling of the palate for several days, 26.
Some vesicles in the mouth on the hard palate, 32.
Some pustules in mouth (with return of burning in mouth and throat), (one case), (after eighteen hours), 55.
Dryness of the mouth, 26.
Dryness of the mouth, without thirst (in half an hour), 1.
Dryness in the mouth, with scraping sensation in the throat, 11. [150.]
Complains of his mouth being parched, 40.
Burning in mouth and throat (after one hour), 55.
Burning sensation in mouth and pharynx, 59.
Mouth feels as if burnt, 26.
Burning scraping in the mouth and throat, extending low down into the œsophagus, not relieved as formerly by cold water, lasting over two hours (soon), 30.
Saliva.
Increased secretion of saliva, 13, 14 ; (after one hour), 62 ; (after four hours), 1.
Profuse salivation, soon, 36.
Profuse secretion of saliva and mucus, 13.
Collection of water in the mouth, 9.
Taste.
Taste at first agreeable, like chocolate; but soon followed by the peculiar burning (effects of the roasted seed), 26. [160.]
Taste at first sweetish, afterwards extremely bitter and burning; the scraping-burning taste was coincident with increased warmth and accumulation of saliva, 26.
Acrid burning taste in mouth and throat (1 or 2 drops), 57.
Taste sometimes burning, sometimes scraping (from a drop of the oil), 46.
Taste flat, 26.
Nauseous, flat taste, 13.
Taste pasty, 13.
Bad taste (immediately), 54 ; (second day), 58.
Sharp sour taste rising up from the stomach, 11.
The burning sensation has risen above the entrance of œsophagus, and is accompanied by a remarkably acrid taste in the back of the mouth like pimento (after one hour), 62.
Somewhat bitter taste in the mouth (immediately), 9. [170.]
Taste as after almonds, 14.
Water tastes flat and nauseous, and causes a feeling of emptiness; he drinks very little on account of a severe burning in the throat, 13.

THROAT

Objective.
Redness and smarting of the throat (third day), 54.
Throat red and sore (second day), 60.
Hawking of mucus, which has a sour taste, like vinegar, 12.
Subjective.
Dryness in the throat, with sense of increased irritation of the pharynx, during inspiration, almost like a slight pharyngeal angina (in twenty-four hours), 1.
Throat dry.
Sensation as though a morsel were in the throat, which he was unable to swallow, 14.
Pain in throat (soon), 60.
Burning in the throat, 11 ; (immediately), 54. [180.]
Burning in the throat and stomach, 22.
Burning in the throat, as if he had eaten pepper, 12.
Burning and contraction of the throat and tongue, 37.
Constant burning and contraction of the throat, 24.
Sensitive burning and scraping in the throat, 13.
Burning pain in the throat, 40.
Intense burning sensation in the throat, and all down the œsophagus (after half an hour), 58.
Feeling of warmth in the throat, and along the œsophagus, sometimes extending to the pit of the stomach and lasting several minutes (immediately), 21.
Complaints that his throat was swelling, 40.
Scraping in the throat, 10. [190.]
Scraping in the throat, lasting six hours, 9.
Scraping in the throat, causing frequent hawking, 11.
Scraping at the throat, worse during an expiration, 46.
Scraping in the throat, followed by burning in the chest, 6.
Slight scraping in the throat, with sensation of warmth in the back of the mouth, lasting half an hour, disappearing after cold water (soon), 30.
Burning scraping in the throat and fauces, 13.
Rawness in the throat, 9.
Intolerably acrid sensation in the throat and all down the œsophagus, 52.
Jerking and shooting through the throat, 13.
Scraping tingling in the throat, 8. [200.]
Tickling followed by scraping and then burning, at the point where the hard and soft palates unite (soon), 14.
Uvula and Tonsils.
Redness and elongation of the uvula, 14.
Swelling of the tonsils, painful to external pressure, 11.
Titillation in the right tonsil (in a quarter of an hour), 1.
Fauces, Pharynx, and Œsophagus.
Increased warmth in the fauces, 14.
Burning in the fauces; relieved on inspiration; aggravated by expiration, 14.
Scraping in the fauces, followed by burning, and afterwards tickling in the larynx, 14.
Feeling of warmth along the pharynx and œsophagus, extending to the pit of the stomach, lasting several minutes (soon), 34.
Burning in the pharynx and bowels (from the effluvia), 44.
Burning in the pharynx (again on the second day), allayed a little by drinking water, 1. [210.]
Acrid sensation in pharynx, 54.
Severe pain in the œsophagus (soon), 53.
Burning extending up the œsophagus, 14 ; (after three-quarters of an hour), 62.
Prickling at the entrance of the œsophagus (while swallowing the dose), 53.
Frequent inclination to swallow, which always causes pain on the left side of the œsophagus, as though a small ball were being pressed through its wall, 30.
Constant irresistible inclination to swallow saliva, with a sensitive pain deep in the œsophagus, as if a small ball were being pressed out of the left side, lasting half an hour, relieved after cold water, 30.
Swallowing.
Difficult swallowing, 26.
External Throat.
Swelling of the submaxillary glands, painful to touch, 11.

STOMACH

Appetite.
Very great appetite, after the pains had entirely ceased, 62.
Hunger, without appetite, 32.
Unnatural hunger, with emptiness of the stomach, 32.
Appetite diminished, 11. [220.]
Appetite and thirst very slight, 11.
Loss of appetite, 9, 12, 40.
Loss of all appetite, 27, 46.
Little appetite at lunch, with feeling of repletion after eating very little (after six hours), 1.
Loathing of his usual breakfast, soup a l'eau (in eleven hours), 1.
Although without appetite, and even with a feeling of fulness, he eats his usual allowance at lunchtime (after five hours), 1.
Thirst.
Considerable thirst (second day), 58.
Thirst intense, 60 ; (after one hour), 62.
Aversion to beer, 11.
Eructation and Hiccough.
Eructations, 9, 32 ; (after one, two, and four hours), 1. [230.]
Eructations of water in her mouth, 4.
Eructations, nausea, and weakness, 14.
Constant eructations of water from the stomach, 9.
Empty eructations, 11, 32.
Empty eructations, especially in the afternoon, 32.
Empty eructations followed by nausea, 9.
Acrid and burning eructations, 62.
Watery eructations, 12.
Bilious eructations, in the evening, 14.
Hiccough, yawning, 32.
Heartburn. [240.]
Heartburn, 14.
Heartburn, with some nausea; after dinner, 32.
Nausea and Vomiting.
Nausea, 3, 8 ; (after one hour), 12 , etc.
Nausea and vertigo, increased in the open air, 4.
Nausea with collection of sour water in the mouth, 12.
Nausea and eructations, 26.
Nausea and eructations after every drink, 27.
Nausea and desire to vomit (after half an hour), 9.
Nausea, with inclination to vomit, after taking some milk, 13.
Nausea and vomiting (larger doses), 57. [250.]
At times nausea, seldom vomiting; the latter especially in women, 21.
Constant nausea, with accumulation of water and saliva in the mouth, with slight chilliness, 13.
Unusual nausea, 13.
Sleep sound until midnight, after which it was disturbed by much nausea, followed by sudden vomiting of a sour, exceedingly strong-smelling fluid in rather large quantity; after the vomiting, diarrhœa, with a feeling as though a fluid were swashing about in the abdomen, 11.
Great nausea, 2.
Great nausea, as if to vomit, 7.
Insufferable nausea, with inflation of the bowels and borborygmi in the epigastric region (in three hours and a half), 1.
Continual inclination to vomit, which he tries to restrain (in half an hour), 1.
Retching, with vomiting of food and some water, 9.
Frequent retching, with accumulation of water in the mouth, 13. [260.]
Violent retching and vomiting, with rumbling in the abdomen and diarrhœa, 39.
Violent retching with very difficult vomiting of yellowish water, of an oily smell, and sweetish-bitter, oily taste (after one hour and a half), 13.
He was obliged to lean against the washstand with all possible force in order to resist the spasmodic retching, 13.
Vomiting (one case), 52.
Vomiting followed by diarrhœa, 22.
Vomiting, borborygmi, and diarrhœa, twenty-four times in succession, 41.
Severe vomiting (after five minutes), 60.
Severe vomiting (after five minutes) of matter containing numerous streaks of a white, shiny, emulsion-like substance, mixed with clear, glairy fluid (after three-quarters of an hour), 60.
Violent and very copious vomiting, for three-quarters of an hour (soon), 53.
Sudden violent vomiting, frequently repeated, of whitish-yellow, frothy liquid; with most violent contractions of the stomach, 13. [270.]
Vomiting of light and glairy matter (one case), (after eighteen hours), 55.
Vomiting of a very large quantity of sour, strongly smelling fluid, 11.
Vomiting of some water, mucus, and food, with constant nausea, after eating, 9.
Vomiting of mucus with a bitter taste, 2.
Vomiting of bile, 9.
Stomach.
Gastro-enteritis (excessive doses), 57.
Rumbling in the stomach, with heaviness on the chest, 13.
Anxiety, oppression, and pressure in the epigastric region, with great nausea, 13.
Feeling of warmth and burning in the pit of the stomach, 9.
Sensation of emptiness in the stomach (after one hour), 30.* [280.]
An unpleasant sensation of emptiness and hunger, and rumbling in the abdomen (after half an hour), 32.*
Empty, hungry sensation, 32.
Very empty feeling in the stomach before eating, 11.
Sinking in the stomach, with sensation of weakness (after two hours), 32.*
Stomach feels relaxed and is painful to pressure, 13.
Epigastric pain for several days, 40.
Severe pain in the epigastrium (two cases), 52.
After vomiting had continued for a quarter of an hour, she began to complain of severe pain in stomach, not aggravated, however, by pressure, 58.
Burning in the stomach, 4.
Burning as from coals in the stomach, 4. [290.]
Burning and feeling of repletion at the stomach (after ten minutes), 1.
Burning pain at the stomach, 40.
Epigastrium felt hot and tense, 40.
Fulness and oppression of the stomach at midnight, followed by nausea, and afterwards by easy vomiting of the food eaten at supper; then by sweat of the face and comfortable feeling; after half an hour repeated vomiting of the contents of the stomach, which were somewhat bitter, after which he slept well until morning, 14.
Feeling of fulness in the stomach, 13.
Feeling of repletion at the stomach, which impedes respiration (in three-quarters of an hour), 1.
Tension in the epigastric region, 34.
Constriction in the stomach, 13.
Some constriction in the upper part of the stomach, 8.
Cramp in the stomach and upper abdomen, 13. [300.]
Pressure in the stomach, 14 ; (after a quarter of an hour), 1.
Pressure in the epigastric region, 13.
Pressure in the pit of the stomach, 9, 13, 19.
Pressure in the stomach, in the forenoon, 30.
Pressure in the stomach, with anxiety, 13.
Pressure in the epigastric region, and a feeling of fulness, 20.
Pressure and fulness in the region of the stomach and chest, 13.
Pressure and constriction in the epigastric region, 13.
Pressure at the stomach, which changes into nausea, with accumulation of saliva in the mouth (after a quarter of an hour), 1.
Pressure in the stomach, with discomfort of the abdomen, 14. [310.]
Pressure in the stomach, with tickling sensation, qualmishness, and slight spasmodic motions, as though one would vomit, 19.
Pressure in the pit of the stomach, transient, 32.
Some pressure in the stomach, 12.
Sense of weight and heat in the epigastrium, such as is felt after drinking strong spirits (after fifteen minutes); the heat seems to radiate in every direction, from one spot; it is confined to the stomach, and is unpleasant, but not painful (after twenty-five minutes); it becomes a burning and extends to the cardia (after half an hour); it is relieved for a minute or two by a glass of barley-water, 62.
Cuttings in the stomach, afterwards below the stomach, and followed by tearing in the intestines of the right side near the ileum, 12.
Cutting pains beneath the stomach, 12.
Violent colic in the stomach and abdomen, 27.
Scraping in the stomach, followed by slight nausea, 6.
Burning scraping extending down into the stomach and along the intestinal tract, 30.
Sensitiveness of the epigastric region to touch, 14.

ABDOMEN

Hypochondria. [320.]
Pressive pain in the left hypochondria (after nine hours), 1.
Pressure in the region of the spleen, 12.
Sticking in the spleen, in the evening, 14.
Throbbing in the region of the spleen, 32.
Umbilical.
Painful movements about the umbilicus, with increased pain on touch or pressure, 13.
Dull vermicular movements, with slight gurgling about the umbilicus, 13.
Tension between the umbilicus and pit of the stomach, 14.
Tension and movement about the navel, with pressure towards the anus, while lying down, 13.
Griping about the umbilicus, 9.*
Griping and pinching pains in the abdomen, about the umbilicus, extending to the left side of the bowels, 19. [330.]
Violent, dull, spasmodic pain seated in the umbilical region, more violent while sitting with the abdomen bent over than when erect or when walking, 13.
Pressure, with twinging, above the umbilicus, 14.
Cutting about the navel, as though two knives were cutting towards each other in the intestines, relieved by two evacuations; after which a watery stool follows, without any disturbance, 5.
Cutting pains about the umbilicus, 12.
Sticking to the left of the navel, 14.
Tearings about the navel, after dinner, 9.
Pains about the umbilicus, as though the intestines were twisting, followed by tearing in the left side of the abdomen (after one hour), 12.
Twinging and tension in the umbilicus, on going out, with pressing upward to the epigastric region, and sudden nausea, 13.
Coliclike pains about the umbilicus, 14.
Colic, so that she could scarcely get her breath; the cutting pain seemed to be about the navel, extending up to the stomach, and caused her to bend double; thence it extended to the left side of the abdomen, 12. [340.]
Very transient colic below the navel, in the evening, with distended abdomen, followed by urging to stool, 14.
General Abdomen.
Fulness, tension, and rumbling in the abdomen, 13.
Flatulent distension of the abdomen, with sensation of heaviness in it, 30.
Abdomen full, with tension of the parietes, 13.
Abdomen full and distended, with griping above the navel, 10.*
An audible and but slightly felt disturbance of the bowels (after a few minutes), followed by liquid evacuations (after twenty minutes); during the six or eight hours that the effect continued, he had fifteen very copious stools, 63.
Movements in the intestines become perceptible, accompanied by slight griping pains, 33.
Gurgling in the intestines, as though only water were in them, mostly on the left side, 12.*
Rumbling in the abdomen, 34 ; (after five minutes), 32.
Rumbling and gurgling in the abdomen, 13.* [350.]
Rumbling in the intestines, 13.
Rumbling in the intestines, on the left side, 13.
Rumbling and loud noises in the intestines (after half an hour), 29.
Rumbling in the intestines, and emission of offensive flatus, on rising and while rising, 13.
Borborygmi (after three-quarters of an hour to one hour), 21.
Borborygmi in the bowels, and several eructations (in an hour and a half), 1.
Flatulence, 32.
Flatulence, with slight but frequently recurring coliclike pains, 30.
Flatulence, soon followed by urgent desire for stool; evacuation sudden, with flatulence; stool thin, small (second day), 29.*
Much flatulence, 13. [360.]
Passage of much flatus, in the evening, 32.
Easy emission of flatulence, while walking; indication of speedy stool, 13.
Emission of offensive flatus, 13.
Frequent emission of offensive flatus, 14.
Frequent passage of offensive flatus, 30.
Constant desire to pass flatus, which, however, was emitted suddenly, 13.
Very urgent desire to pass flatus, while sitting, 13.
Movings, rumblings, and gurglings, with painfulness to touch on the navel, 13.
Slight movements and retractions, with dragging pains in the upper abdomen and umbilical region, followed by stool, 13.
Uneasiness, griping, and twinging in the abdomen, 8. [370.]
Unpleasant sensation in the intestines, with rumbling in the abdomen, lasting half an hour (after one hour), 30.
Sensation as though diarrhœa would occur (after four days), 32.
An unpleasant feeling in the abdomen, as though diarrhœa would occur, 32.
Heaviness and confusion of the whole abdomen, with retracted parietes, 13.
Feeling of heaviness in the upper abdomen, 34.
Pains in the abdomen, 22.
Pains in the abdomen, relieved an hour after eating some gruel, 13.
Pains in the abdomen, with passage of much offensive flatus, in the morning, after rising, 31.
Pains in the walls of the abdomen, especially deep, so violent that slight pressure or deep inspiration made it intolerable, 36.
Pain in bowels (with the nausea), (one case), 52. [380.]
Feeling of fulness in the abdomen, with slight griping, 13.
Feeling of fulness in the abdomen, with rumbling and slight colic, 26.
Violent annoying tension and distension of the whole abdomen, with urging to stool, tenesmus, and emission of offensive flatus from the anus; these symptoms are worse while sitting than while walking or standing, 13.
She seemed to feel distinctly the medicine work downward into the cæcum, and cause a contraction; as it approached the umbilicus, it caused some twinging, 6.
Griping in the transverse colon, repeated before every stool, 4.
Griping and gurgling, with feeling of fulness in the abdomen, and pressure towards the anus, 13.
Slight griping after dinner, transient, 31.
Griping pains in the upper abdomen, 13, 14.
Slight griping pains in the intestines, especially aggravated by touch, 13.
Violent griping pains, with rumbling and gurgling in the upper abdomen, soon followed by emission of offensive flatus, 13. [390.]
Dragging spasmodic pains in the upper abdomen, especially while sitting, followed by tensive pain, 13.
Cutting in the bowels, followed by stool, 12.
Cutting pains, tenesmus, and alvine evacuation, at first pultaceous, then liquid, mingled with mucus and bile (after two hours), then three more diarrhœic stools of a greenish-yellow, 1.
Cutting pains in the intestines and about the umbilicus, 12.
Cutting pains in the bowels, with emission of fetid flatulence (after twelve hours), 1.
Sticking in the cæcum, 14.
Tearing in the abdomen, while eating, 9.
Tearing in the transverse colon, 9.
Twinging and cutting pains, mostly in the colon, 9.
Frequent twinging pain in the abdomen, 14. [400.]
Spasmodic twinging pains in the abdomen and about the umbilicus, while walking, 13.
Coliclike pains, with rumbling in the abdomen, and feeling as if diarrhœa would come on, lasting half an hour, and disappearing after passage of flatus (second day), 29.
Violent colicky pains and passage of loud offensive flatus (after six hours), 29.
Pressive coliclike pains in the abdomen, 13.
Colic (after one hour), 62.
Colic, generally, 21.
Colic, after eating, 14.
Colic and tenesmus, 48.
Slight colic, 25.
Violent colic, after eating, and while walking, 14. [410.]
Griping colic, with pressure towards the anus, 13.
Slight griping colic, with dragging towards the anus, 13.
Flatulent colic, in the evening, 14.
Flatulent colic, disturbing sleep; the colic lasted about half an hour, and was relieved after the passage of much noisy flatus (after six hours), 29.
Slight tenderness of abdomen, but none of epigastrium (one case), (after eighteen hours), 55.
Painful sensitiveness of the abdomen, especially felt on pressing upon it, 13.
Soreness in the abdomen on coughing, 14.
Whole abdomen sore and easily painful, 13.
*Swashing in the intestines, as from water (second day), 12.
Swashing, rumbling, and griping in the intestines, 13. [420.]
Feeling as though fluid were swashing in the abdomen, 11.*
Hypogastrium and Iliac Regions.
Very severe pain in lower part of bowels; not increased by pressure (after two hours), 58.
Pressive pain in the lower abdomen and bladder, 32.
An undefined pain in the left inguinal region, 14.
Tensive pain in both inguinal regions, 13.
Pressive pain above the posterior superior spine of the left ilium, 32.

RECTUM AND ANUS

Rectum.
Feeling within the rectum, as though purging would follow, 13.
Anus.
Swelling and burning extending to the anus, 23.
*Upon pressing upon the umbilicus, a painful sensation is felt down to the anus, where there is constant pressing outward, 13.
Burning about the anus, so that he was scarcely able to sit, 14. [430.]
Burning and itching in the anus, 13.
Feeling of constriction, with, at times, stitches in the anus, on walking, 11.
Dragging to the anus, as if diarrhœa would easily ensue, 13.*
Pain in the anus, as if a plug were sticking in it, and forcing outward, 13.*
Sore pain, with burning in the anus, after moving about, 14.
Stool, followed by very painful sore sensation within the anus, with feeling as though the rectum was swollen and would protrude, with constant desire for another evacuation; compression of the abdomen and pressure towards the intestines, causing pain extending into the genitals and ending in the glans penis as a sticking, so that, on account of the pain, he became very anxious and oppressed, and was obliged to keep as quiet as possible; accompanied by sweat upon the forehead and nausea, with vanishing of sight and hearing; the pain was more violent when the body was bent over than when sitting, riding, or walking, which latter he was scarcely able to do on account of a very sore pain on the outer portion of the anus; the pain was gradually relieved by rest, when the anus seemed to return and become contracted; this latter was followed by general prostration, ill-humor and loss of appetite, 13.
Scraping in the anus, immediately after a stool, 14.
Pulsating, sticking, and burning in the anus, 13.
Itching at the anus (after twelve hours), 1.
Itching at the anus, obliging him to rub, 30.
Urging. [440.]
Urging to stool, in the morning, in bed; on rising, a stool, rather soft, light-brown, followed by a very sore sensation in the anus, 13.
Urging to stool, with fulness in the abdomen and apparent fulness of the rectum; the stool was scanty and difficult to pass, 13.
Urging and tenesmus while sitting at stool, with, however, passage of very little thin stool of a green-brown color, evacuated at three times and very forcibly as if shot out of the rectum, 13.
Great urging and pressing towards the rectum, 13.
Great urging to stool, the evacuation accompanied by griping, spasmodic pains in the abdomen; stool rather soft, dark-brown, offensive, 13.
Immediate urging to stool on returning to the house, 13.
Sudden urging to stool; he was unable to reach the closet, nevertheless was obliged to sit a long time, 8.
Frequent urging to stool without result (third day); the usual stool followed on the fourth day with some colic, succeeded by slight pains in the rectum, 13.
*Constant urging to stool, followed by sudden pasty evacuation, which is shot out of the rectum, of a dirty-green color and offensive, 13.
Soon after luncheon, tenesmus and scanty evacuation, mixed with mucus (in five hours and a half), 1.

STOOL

Diarrhœa. [450.]
Diarrhœa, 24.
Diarrhœa, with urging, 32.
Hypercatharsis (larger doses), 57.
Free action of the bowels (repeatedly induced by putting two or three drops upon a surface denuded of its epidermis by a blister), (Rayer), 51.
Violent purging, with great pain in bowels (after eight minutes), passages being without pain and apparently involuntary; the fæces had numerous streaks of a white, shiny, emulsion-like substance mixed with a large quantity of clear glairy fluid (after three-quarters of an hour), 60.
Recurrence of purging, after the first attack had been relieved (one case), (after eighteen hours), 55.
Numerous evacuations, the first flocculent, the others yellow and green, 7.
Very frequent stools (two cases), 52.
Twelve diarrhœic stools, without colic (second day), 54.
Bowels were opened freely (after one hour and a half), and at intervals for the ensuing thirty hours; in all, some thirteen movements, 59. [460.]
Stool at first nodular, mixed with many white points, the second containing many white long (3") worms as large as threads; the remaining nine evacuations offensive and bilious, or slimy and at last watery, 6.
Ten copious, mucous stools, with some colic, but without tenesmus (after one hour), 62.
Five stools, with profuse sweat, especially on the forehead, 41.
Five soft, slimy evacuations, without griping, with some tenesmus, 25.
Four forcible evacuations, 41.
Three watery stools (second day), 12.
Acts upon bowels as a drastic purgative, causing three or four copious watery evacuations (1 or 2 drops), (after one or two hours), 57.
Bowels very freely opened, twice (after one and two hours), 58.
Two rather scanty diarrhœic stools, 53.
Two dirty-yellow, mealy stools, 11. [470.]
The usual stool in the morning was followed by a second, after three hours, 13.
Solid stool (soon), followed by a liquid stool with slight borborygmi and slight colic, in the epigastric region and hypochondrium; a third stool, also liquid (after two hours and a half); a fourth stool (liquid), (after three hours and a half); and a fifth stool, also liquid (after six hours and a half), 46.
A pasty light-brown stool covered with mucus, with frequent urging, followed by rumbling and gurgling in the left side of the abdomen; after another hour, a second, very soft, pasty, mucous, and urgent stool, of a grayish-green and dirty-brown color, which is evacuated forcibly, 13.*
Soft stools, without tenesmus, and without heat in the anus, 21.
Watery stools, in the afternoon (second day), 12.
Stools exceedingly large, 33.
Profuse stool, with rumbling in the abdomen, 32.
Stool diarrhœa-like, light-yellow, accompanied by sweat , crawling in the occiput, pressure upon the larynx, especially the left side, 14.
Soft stool, 13.
Pasty stool, with burning in the anus, 10. [480.]
A thin stool every day at the accustomed time, 30.
Thin stool, with scratching on the posterior left wall of the anus, 14.
Thin stool, with passage of flatus, in the afternoon; in the evening, urging to stool reappears, but without result, 32.
Stool very thin, like yellowish water, forcibly evacuated, 21.*
Thin liquid stool, with passage of flatus (second morning), 29.
Watery, painless stool (after three hours and a half), 62.
Slimy stool, with tenesmus, 12.
Stool with some rumbling and colicky pains in the epigastric and hypochondriac regions, 27.
Stool at first fecal, afterwards watery, with slight sticking pain in the abdomen, 3.
Constipation. [490.]
Constipation (second day), 46.
Constipation followed after some days, 27.
Constipation (absence of the usual daily evacuations), and, at length, in seven hours, a scanty evacuation, caused by the efforts of the abdominal muscles, unaided by the peristaltic action of the bowels, 1.
The usual morning stool did not occur, but in the evening an unsatisfactory soft stool passed slowly and sluggishly (third day), 29.
Stool crumbly, solid, passed with exertion, 13.
Stool tenacious, 11.

URINARY ORGANS

Urethra.
Burning in the urethra, while urinating, 14.
Micturition caused burning in the urethra, 11.
Urging to urinate, 14.
Micturition.
Frequent micturition, 13, 14. [500.]
Micturition nearly every half hour, 11.
Increased secretion of urine, 11.
Increased secretion of urine, which was turbid and cloudy, 26.
Great increase of urine, 15.
Urine greatly increased in quantity, 33.
Passage of much yellow urine, 14.
Profuse secretion of urine, 10, 19.
Profuse micturition, at least equal to the amount of drink, 14.
Urine.
Urine pale, frothy, 13.
Urine pale, depositing a white sediment, 14. [510.]
Urine standing over night is pale orange-yellow, with a slight turbid sediment, which is at first somewhat flocculent, 13.
Urine which had stood through the night looked almost blood-red, and had deposited a thick mucous sediment, 11.
Urine, at night and in the morning, dark fiery red, depositing a very flocculent, turbid sediment, with some clearer substances; the surface covered with an oily pellicle, 13.
Foaming urine, in the morning, 14.
Turbid urine, 36.
Urine burning, soon becoming turbid, and depositing a copious brown sediment, 30.
The urine has a cloudy deposit, which, however, gradually disappears, and after twenty-four hours brownish crystals form, which seem to float where the clouds have been, and adhere to the walls of the glass, 14.

SEXUAL ORGANS

Male.
The inner surface of the prepuce is slightly inflamed and irritable, with some secretion, 32.
Constant painful erections, 13.
No erection in the morning during the proving, contrary to custom, 30. [520.]
Burning in the glans penis, while urinating, 14.
Burning in the glans penis on urinating, immediately followed by renewed desire to urinate, 14.
Painful sensitiveness of the penis, with redness of the glans, and stitches in the urethra, 13.
*Frequent corrosive itching on the glans penis and on the scrotum, 30.
Scrotum shrivelled, with severe itching, especially disturbing the sleep; relieved by scratching, which, however, caused a voluptuous sensation; this itching was troublesome for several days, 31.*
*Corrosive itching pain on the scrotum, lasting all day, worse while walking; there was no eruption, only redness of the part (third day), 29.
Left testicle retracted, the right relaxed, 14.
Drawing in the left spermatic cord hindering walking, 14.
Female.
Menstruation, scanty (after fourteen days), 3.

RESPIRATORY ORGANS

Larynx, Trachea, and Bronchi.
Laryngeal catarrh, 32. [530.]
Collection of mucus in the larynx, which rattles somewhat, in the evening, 14.
Accumulation of mucus in the larynx, 13.
Accumulation of mucus in the larynx, with tickling and irritation, 13.
Constant collection of mucus in the bronchials, which he is unable to remove, 14.
Frequent hawking, cough, and irritation to cough, 14.
Pressure in the larynx, especially the left side, with the stool, 14.
Provocation to cough, with accumulation of mucus in the trachea, 32.
Voice.
Speech low, 13.
Voice hollow; he is obliged to hawk constantly, 14.
Voice rather hollow than hoarse, as though he had a severe cold, 14. [540.]
Voice husky (second day), 60.
Voice hoarse and rough, 14.
Cough and Expectoration.
Cough in the evening, with white mucous expectoration and oppression of the chest, 14.
Cough with difficult yellowish expectoration; spitting of blood, after which the yellowish expectoration continued a long time, 36.
Frequent cough, in the morning, with expectoration, 14.
Constant cough, 13.
Expectoration of much tenacious mucus, which tastes sour, 11.
Respiration.
Breathing short and hurried, 40.
Respiration slow and powerless, 59.
Respiration, 12, 22. [550.]
Oppressed respiration, 13.
Respiration impeded and painful, 36.
Anxious, oppressed, difficult respiration, 13.
Respiration difficult, with constriction of the chest, 13.
*Sensation as though he could not get air enough into the air-cells, and could not perfectly expand the lungs, 14.
*On inspiration, it seems as though he could not expand the lungs, 14.
Difficult breathing, 34.
Very short breath after the stools, 14.
Respiration through the nose stopped, 13.
Dyspnœa, aggravated by going upstairs, 14.

CHEST. [560.]

Feeling of hollowness in the chest, 14.
Peculiar discomfort in the chest and abdomen, 27.
Peculiar malaise in the chest and abdomen, which forces him to yawn and stretch, 46.
Feeling as though there was mucus in the lungs, which could not be removed by hawking, together with difficult breathing, and slight whistling, on deep inspiration and expiration, 14.
Pains in the chest, 36.
Fulness of the chest, somewhat impeding respiration, 13.
Fulness, pressure, and burning in both thoracic cavities, 13.
Feeling of fulness in both thoracic cavities, with burning stitches in the left thorax, and towards both scapulæ, 13.*
Tightness at the chest, 40.
Pressure, deep within, at the middle of the chest, 14. [570.]
Oppression of the chest, 14, 20.
Oppression of the chest, in the evening, 14.
Oppression of the chest on deep inspiration, 14.
Oppression and anxiety, 13.
Severe oppression of the chest, in the evening, 14.
Stitches in the left thorax, 13.
Tearing along the edges of the ribs, extending backward and down to the small of the back, 2.
Painfulness of the chest to touch, 14.
Sudden throbbing in the region of the aorta, 14.
Front.
Transient pressure over the sternum (after seven hours), 1.
Sides. [580.]
Pressive pain in the left chest, and left hypochondrium (after ten hours), 1.
Pressive pain in the left chest, with feeling of oppression (after twelve hours), 1.
Sticking in the left half of the chest, 14.
Sticking in the right lower third of the chest, during inspiration, 14.
Violent stitches through the middle of the left side of the chest, in the afternoon, 14.
Throbbing in the posterior portion of the right thoracic cavity, 14.
Frequent throbbing-bubbling in the lower right side of the chest, between the sixth and seventh ribs; next day, very frequent throbbing and pulsating in the same region, 14.

HEART AND PULSE

Præcordium.
Very perceptible pulsation and throbbing of the heart, 13.
Smarting in the præcordial region on expiration, repeated after one hour, 14.
Frequent sticking in the præcordial region, 14. [590.]
Some jerkings in the left side of the heart, 10.
Heart's Action.
Palpitation of the heart in the afternoon, 14.
Palpitation after dinner, especially when lying down, 14.
Violent palpitation, 34.
Pulse.
Accelerated pulse, 26.
Pulse rapid and weak (soon), 27.
Pulse small and rapid (after three-quarters of an hour), 60.
Pulse small, rather rapid, 13.
Frequent and weak pulse, 46.
Pulse so weak and quick that it could not be counted (after three hours), 60. [600.]
Pulse 108, very feeble, 59.
Pulse 120 (after one hour and three-quarters), 60.
Pulse 150, and very weak (after two hours and three-quarters), 60.
Pulse small, weak, 64, 22.
Pulse full, 13.
Feeble pulse (one case), (after eighteen hours), 55.
Pulse weak and small, 33.
Small, contracted pulse (after four hours), 1.
Pulse at first weak and small, becoming stronger and fuller than usual, 33.

NECK AND BACK

Neck.
Pain in the muscles of the left side of the nape, on nodding the head (after four hours), 30. [610.]
Fulness extending up to the neck from the abdomen, with pressure in the pharynx, 14.
Pressure in the right side of the neck, 13.
Pressure and drawing in the cervical vertebræ, 14.
Sticking between the nape and occiput, 14.
Back.
Violent pains in the back and the lumbar region, in the space between the lumbar vertebræ, false ribs, and ilium, 56.
Lumbar.
Warmth starting from the lumbar vertebræ, 14.
Pains in the small of the back, 36.
Violent sticking in the region of the left kidney, in the afternoon, taking away the breath, 14.
Stitches in the left renal region (after four and a half hours), 1.

EXTREMITIES IN GENERAL

Trembling of the hands and feet, 11. [620.]
Weakness of the arms and legs (from the effluvia), 44.
Pains in the limbs, 34.

SUPERIOR EXTREMITIES

Heaviness and weariness of both arms, 13.
Tearing in the right arm, extending to the upper arm, afterwards down to the fingers, 12.
Shoulder.
Pressive pain in the right shoulder-joint, 14.
Sticking in the left shoulder-joint, 14.
Tearing in the right shoulder, 12.
Arms.
Heaviness of the upper arm, which is easily fatigued, 20.
Heavy tense sensation in both upper arms, 13.
Pain on the inner side of the left upper arm, 32. [630.]
A rheumatic pain in the left upper arm, waking him from sleep, disappearing during the day, 32.
Tension, weary pain, in both upper arms, 13.
Tension and pressure in the right upper arm, with sensation of weariness extending to the hand, 13.
Tearing in the right upper arm, and afterward in the right shoulder-joint, 14.
Sudden tearing pain in the left upper arm, especially in the deltoid muscle, lasting two hours (after four hours), 32.
Elbow.
Boring pain in the left elbow at noon, 14.
Forearm.
Drawings in the right forearm, 14.
Tearing in the left forearm, 14.
Wrist.
Drawing above the right wrist; in the evening, 14.
Fingers.
Drawings and tearings in the left middle finger, 14. [640.]
Tearing pain in the finger-joints of the right hand, lasting several hours, 30.

INFERIOR EXTREMITIES

Weariness and exhaustion in the lower extremities, 13.
Prostrated and exhausted feeling in the legs, 13.
Hip.
Tensive pain in the left hip-joint, which makes it difficult to rise from the seat, 11.
Thigh.
Paralyzed feeling in the left thigh, 14.
Awoke, after midnight, feeling as though the thighs were as heavy as lead, 13.
Burning and swelling of the nates where they approximate by the anus, after moving about, 14.
Itching burning in the middle of the left thigh, 14.
Especially painful pressure in the thighs, 13.
Sore pain between the left thigh and the scrotum (second day), 30.
Knee. [650.]
Tension and prickling in the knee-joints, 13.
Cramplike pain in the right knee-joint, transient (after ten minutes), 32.
Crawlings in both knees, 13.
(Crawling and tearing in the knee-joints), 13.
Leg.
Twitching of the legs during the midday nap, 14.
Pains in the legs and feet, 36.
Tearing in the left leg, 10.
Ankle.
Heaviness and pressure in the ankles, in the evening, 14.
Sticking extending from the right external malleolus to the forepart of the foot, 14.
Foot.
The feet failed him on going upstairs, 14. [660.]
Feeling of nervous weakness in the feet, 12.
Sticking on the margin of the left foot, as though she had turned it, while sitting, 12.
Rheumatic tearings in the left foot, 14.
Frequent pain, as if sprained, in the left foot, 32.
Jerking in the left foot, while sitting, 14.
Frequent cramplike pain in the sole of the left foot, and on the inner side of the foot, 32.
Jerkings and tearings at times in the sole of the left foot, 10.
Toes.
On walking he is attacked, three times in succession, with sticking and tearing pains as if sprained, especially in the left metatarsal bone of the great toe, so that he is unable to step fairly upon it, 14.
Violent sticking in the left great toe, and after a quarter of an hour also in the right, 14.
Rheumatic tearing in the right great toe, 14. [670.]
Painful prickling and sticking in the right great toe where the nail enters the skin, 14.
Crawling in the right little toe, 14.
Jerklike crawling in the right great toe, 14.

CROTON TIGLIUM. GENERAL SYMPTOMS

Objective.
Sudden emaciation, 36.
Trembling of whole body, 12.
Weakness, 26, 33.
Great weakness, 32, 36.
Great weakness on rising in the morning, with trembling of hands and feet, 11.
Very great debility, 48.
Prostration, 13. [680.]
Prostration of whole body, with frequent slight nausea, 18.
Stool followed by prostration, and some pain in abdomen, 13.
General prostration, 36.
State of collapse, 40.
During vomiting, and for two hours after, constant tendency to faint, and deathly, indescribable feeling of prostration (one case), (after eighteen hours), 55.
Attacks of faintness, 16.
Lay in a lethargic state, sometimes drawing himself up as if in pain (after three hours), 60.
Very restless; tossing convulsively about as if in pain (after one hour and three-quarters), 60.
Generally lying quiet on belly, but occasionally tossing about (after two hours and three-quarters), 60.
Anxious oppressed tossing about in bed, with loss of sleep, 13. [690.]
Uneasiness, 34.
Subjective.
Disinclination for every exertion, 13.
Weariness, 26.
Weariness, with prostration of the limbs, in the morning, on waking, 13.
General weariness and exhaustion, with ill-humor, 13.
Feeling of weakness, 32.
Sensation of complete dulness of the whole body, 13.
General sick feeling, 26, 34.
General sick feeling, worse after eating bread and butter; she was obliged to lie down, 9.
Discomfort after dinner, 31. [700.]
Malaise, which is soon allayed; but a sort of nausea remains a long time after (in one hour), 1.
Frequent stitches, with profuse sweat on the forehead, 39.
Tearings in left side, extending from groin up to the right nipple, lasting several minutes, 12.
The pain causing nausea is aggravated while lying, 13.

SKIN

Objective.
Redness of the skin (from triturating the seeds in a mortar), 41.
Slight redness of the skin, with a sensation of coldness, at last followed by slight warmth, 18.
Rubescence to a greater or less extent dependent upon the individual susceptibility; this gradually increases until a general, though moderate, tumefaction occurs, apparently affecting parts deeper seated than I have seen occur from the use of any other external irritant; this is succeeded, in a period varying from six to twelve hours, by numerous vesicles, some distinct, others confluent, differing in size and shape; at first containing merely limpid serum, afterwards distinct and consistent pus, and terminating in slight scabs. The redness produced is not of a vivid, but of a dull brickdust hue. These circumstances, though regular in their course, vary in extent according to the parts upon which the oil is applied; thus, on the abdomen, I have never been able to excite so active a rubescence as in other parts of the body. Over the muscular region of the arms and legs the effect is not so violent as where the bones are more superficially situated. The most powerful effects are produced upon the face, scalp, larynx, and chest, according to the observations I have made, in the order enumerated. When Croton oil is applied to the face and scalp it is frequently succeeded by erysipelas, but I have never seen any destructive or suppurating process established; whenever applied only erysipelas followed its use upon any part of the neck, abdomen, or extremities. In general, its effects are certain when applied to any part of the body, with the exception of over the abdominal muscles; at least I have never seen it fail of producing the sequelæ described when applied upon any other part of the body, 38.
Enlargement of a cutaneous gland in the right lower lid, half an inch from the caruncula lachrymalis; the skin is reddish and elevated, as large as a mustard-seed; disappearing after four days, 14.
Eruptions, Dry.
Eruption of red pimples as large as millet-seeds, with corrosive itching and sore pain when touched or rubbed (from external application), 29.
Erythema, with pustules (second day), forming crusts the next day, 28. [710.]
Eruption on the right side of the septum of the nostrils; when washing in the morning the spot was painful to touch, was red, of the size of a pea; on the same day it formed a small slightly elevated crust, which desquamated on the sixth day; the epidermis continued red and tender, and again desquamated, 14.
Burning-itching eruption round about the neck; some pimples appear seated on a red base, small, hard, and slightly elevated, lasting four or five days (after seven days), 31.
Papulous eruption on the face, 14.
Erythema of the face (not unusually), often symmetrical, lasting for a few days, with distinct heat; and this when there could have been no direct application of the remedy to the face, 56.
Eruptions, Moist.
*Vesicular eruption on the scrotum and penis (the patient's hands not having touched the parts), (from rubbing the oil upon the limbs), 49.
Eruption of small vesicles on the labial commissures, right upper eyelid, and left buttock (caused by touching these parts when the hands were covered with the ejecta), (second day), 53.
Erysipelas phlyctenoides of the face, ending in desquamation in four hours (from an external application to the neck), 43.
Several itching vesicles on the chin, which coalesce and form a scurf, which becomes moist on pressure; after about five days the crust desquamates and leaves a red spot which lasts a long time (after four days), 32.
On the left thigh opposite the scrotum, a red moist spot, exuding an offensive moisture; it is painfully sore to touch and on walking, which also causes troublesome biting, 30.*
Eruptions, Pustular.
The eruption which is brought out by the external use may be divided into 5 stages: 1. Rubefaction of the skin; 2. Formation of vesicles; 3. Conversion of the vesicles into pustules; 4. Desiccation of the pustules; 5. Desiccation and falling off of the crusts.

These different periods or stages are not uniformly to be observed; there are most conspicuous when the friction has been made with 10 or 12 dorps of the oil on a part of the skin where there is much subjacent cellular tissue. The patient at first experiences a tingling warmth, which is quickly followed by a considerable redness, extending an inch or so beyond the sphere of the rubbing. These appearances are generally noticed within seven or eight hours, sometimes one or two, at other times not for ten or twelve hours; the differences of time required depending, no doubt, on the delicacy of the skin. In from fourteen to twenty-six hours myriads of small, close-set vesicles make their appearance upon the inflamed skin; occasionally a few of the vesicles become greatly magnified, forming true phlyctenæ, filled with a turbid lymph, which speedily changes into a purulent matter. In twelve out of thirty-one case, reported by our author, the vesicles passed to desquamation without undergoing the suppurative process. The usual period at which the serum becomes puriform is from thirty-six to fifty-four hours after the application of the oil. In one or two days subsequently the pus begins to exude, and forms grayish crusts over the pustules, and the desquamation is generally over by the eighth or ninth day. If the Croton oil is rubbed upon any part which has been recently vesicated the eruption is, as we might expect, more speedy and abundant, 51. [720.]

A peculiar pustular and vesicular eruption (external application), 57.
Papulo-pustulous eruption (second day), 50.
The pustules are riper; their bases are inflamed; some are larger than others, and have already lost the inflammatory areola, but are full and tense. There are large phlyctenæ on the scrotum, and some pustules on the pubis; the glans penis is partly denuded of its epidermis (from the contact of the patient's hand covered with the oil). The urine is darker-colored; urinating causes pain at the end of the penis, owing to the condition of the glans and prepuce (third day), 50.
Not much smarting in the eruption; there is some heat. A general redness in the affected part, which is covered with numerous white, glossy, tense pustules, having but slight areolæ. Those which were in the same stage of development yesterday are now desiccated. Some small papulous vesicles have newly appeared; others, with areolæ, are just changing into true pustules (fourth day), 50.
The pustules which desiccated yesterday have left only a yellowish spot or crust, formed of pus and dried epidermis; those which were then at their height have sunken; there are visible very small elevations, without areolæ, remarkable for their regular shape, their small size, and the complete absence of surrounding redness; these are pustules developed between the laminæ and the horny layer of the epidermis ( intra-epidermic pustules ), (fifth day), 50.
General redness diminished. The pustules are less numerous, and among them are some which are projecting, sensitive, surrounded by areolæ, and whose contents are of a reddish hue, owing to blood-globules mingled with the pus; these are dermic or pustules. A pustule was noticed surmounted by another smaller one. This is the two-story pustule . There are some thick, crusts caused by the patient's scratching open the pustules (sixth day), 50.
Diminished eruption and redness; more crusts from torn pustules. An herpetic spot, which was situated at about the centre of the eruption, has almost disappeared (seventh day), 50.
The evolution of the latter pustules seems more speedy than on the first days, so that those which were fully matured yesterday have now hardly left a trace; even the raised epidermis has subsisted.

The two-story pustule , already observed, is developed; the top story, formed by an intra-epidermic pustule, has increased in size, probably from the effect of endosmosis; its circumference is no longer even with that of the lower pustule (eighth day), 50.

All the pustules have sunken; desquamation is beginning with the small pustules without areolæ (ninth day), 50.
Desquamation is proceeding; the herpetic spot appears again (tenth day), 50. [730.]
Here and there new pustules, glossy and tense, arrive at maturity, whilst others are desiccating; the herpetic spot has cleared off (eleventh day), 50.
When the scabs fall off from the scratched pustules they are succeeded by pits, while they leave the others still elevated, so that the hand perceives a roughness. Long after the scabs have gone their places are marked by a brownish discoloration, like the coppery hue of syphilides (twelfth day), 50.
The redness diminishes, and the desquamation continues to extend (fourteenth day), 50.
Formation of pustules and almost general inflammation of the walls of the abdomen, followed after several days by desquamation, 28.
Pustules thickly covering the whole scrotum and face; the pustules on the side of the scrotum were flattened and became suppurating ulcers; in other parts the pustules dried and desquamated, 35.
The whole abdomen, even where the oil had not been applied, was covered with numerous small elevated pustules, surrounded with bright-red areola, but without itching, and with no general symptoms (after two hours); violent itching began in the night, disturbing sleep and causing general discomfort; on the next morning the redness was less marked, and every pustule had a tip somewhat paler than the skin around it; pressure upon the eruption was not painful, but somewhat sensitive; gradually the pustules became pale, and disappeared, without crusts or desquamation; on the eighth day only a few pale-red spots remained, not larger than a grain of corn, 17.
Slight redness, soon followed by burning; on the next morning, while lying in bed on the left side, throbbing, tension, and frequent jerking in the left upper arm, extending to the fingers; this spasmodic jerking involuntarily contracted the fingers; they noticed a large number of large and small, isolated, red-pointed, and roundish pustules; the itching and burning were worse on touch or motion, especially on rubbing with the hand; the arm and shoulder felt heavy; the whole skin was slightly red; the place felt rough and uneven; the small pustules disappeared as whitish, shiny, small elevations; the whole skin became whitish; the large pustules remained red even after five days, when they gradually diminished, with only a very slight whitish desquamation, only noticed when rubbing with the hand, when a few small scales were found upon the hairs of the arm; an itching, which provoked scratching, remained for some two weeks, and also an alternating sensation of heaviness and tension in the upper arm, 18.
On the second day there was some itching in the place where the oil had been rubbed, but the surrounding skin, even where the oil had not touched, was still more red; an eruption of very numerous, isolated, large and small, dark-red pustules; movement of the arm causes some itching and burning; touch, or uncovering the part, even in the room, increased the painful burning and itching; the whole spot was elevated, uneven, and rough; the small pustules disappeared after a few days, leaving a slight elevation of the skin; the large ones remained for five days isolated and red, 18.
Herpetic eruption on the scrotum (from rubbing it into the abdomen), 28.
Subjective.
Itching after half an hour, followed by painful burning, 28. [740.]
Prickling in the lower third of the left lower leg, 14.
Prickling in the first toes of the right foot, 14.
Crawling in the lumbar region, as from beetles, 6.
Itching of the left upper lid, 14.
Itching on the right lower lid, 14.
Itching on the scrotum, 32.
Itching on the left middle finger, and on the right ring finger, 14.
Frequent itching, or rather smarting, as from vermin, in the pubic region, and on the glans penis (second day), 30.
Very troublesome irritating itching on the scrotum (second day), 29.
Prickling itching and burning on the sole of the right foot, 14. [750.]
Corrosive itching on the scrotum, disturbing sleep, relieved by rubbing, which, however, caused erections (third day), 29.
Corrosive itching on the scrotum, and a moist, offensive spot on the thigh; these places afterwards become dry and desquamate, 30.

SLEEP AND DREAMS

Sleepiness.
Yawning, nearly the whole forenoon, 14.
Frequent yawning, 14.
Sleepiness, 13.
Sleepiness and prostration, 18.
Sleepiness towards noon, so that he wished to lie down; after lying down after dinner inability to sleep, with some palpitation of the heart, 14.
Great somnolence and weakness (from the effluvia), 49.
Almost irresistible desire to sleep, 26.
Easy falling asleep, followed by chill, especially across the back, 18. [760.]
Falling asleep from weariness, with numerous anxious dreams, 13.
After the vomiting, fell into a deep sleep which lasted four hours, 53.
Sleeplessness.
Sleep uneasy, 12.
Sleep uneasy, with many dreams, 11.
Sleep very uneasy and full of dreams, 18.
Sleep light, disturbed by many dreams, 11.
Sleep, with sudden waking, although he was unable to remember having a dream, 13.
Night restless; full of dreams, 13.
Sleeps lying on the back, and sudden awaking after an emission, 13.
Dreams.
Sleep very dreamy, 13. [770.]
Sleep disturbed by many dreams, 10.
Sleep, with heavy dreams, till 1 o'clock at night, when she was suddenly awakened by violent headache, 13.
Night full of interrupted dreams; he could not remember ever having passed such an anxious night before, 14.
Dreams about the occurrences of the day, during the afternoon nap, 14.

FEVER

Chilliness.
Surface cold, 40.
Surface of the body cool, 33.
Skin cool, clammy, 39.
Chilliness and shivering, 14.
Chilliness, especially in the abdomen, 8.
In the afternoon chilliness obliged him to seek his bed, where he did not get warm for a long time, 8. [780.]
Very transient attacks of chilliness extending especially over the whole of the back, 13.
Easily chilled, 19.
Coldness, especially of the lower extremities, so that she seemed covered with gooseflesh; she was obliged to lie in bed in order to keep warm, 2.
Sensation of coldness, weakness, and prostration, 22.
Shivering all over (in three hours and a half), 1.
Extremities cool, 22.
Extremities cold, 63.
Coldness of the feet, extending as far up as the calves, 14.*
Feeling of coldness in the abdomen, 14.
Sudden coldness and paleness of the hands, with fingers very much shrivelled, 13. [790.]
Feet cold (after one hour and three-quarters), 60.
Feet and legs cold (after two hours and three-quarters), 60.*
Extremities rather cold (after three-quarters of an hour), 60.
Heat.
Increased temperature of the whole body, followed by prickling-burning warm sensation, 14.
Warmth of body, especially of the face, 26.
Warmth over the whole body, followed by feeling of coldness in the region of the abdominal vertebræ, 14.
Warmth of the surface of the body, especially of the hands, which are usually cold, with remarkably swollen and prominent veins, 13.
Generally increased warmth of the whole body, with slight sweat, 13.
Skin, at first cool, becomes warm, and afterwards always profuse transpiration, 33.
Increased sensation of warmth through the whole body, 13. [800.]
Heat of the body, 12.
Heat and sensation of anxiety, so that she sought for a chair, 6.
Feeling of heat, with increased salivation, 46.
Flushes of heat, 12.
Hot and perspiring, with pulse as high as 190 (after five hours and a half), 60.
Febrile symptoms, 36.
Feverish condition (with the eruption of pustules), 28.
Creeping warmth in the parietes of the abdomen, 14.
Itching warmth in the upper third of the right tibia, 14.
Heat of the face, 13. [810.]
Slight febrile excitement across the whole upper abdomen, 13.
Burning in the cheeks, 14.
Sweat.
Sweat, 15.
Skin moist (one case), (after eighteen hours), 55.
Sweat on the forehead, 24.
Sweat stood in drops on the forehead, and she thought she was unable to go to the house on account of the nausea, 2.

CONDITIONS

Aggravation.
( Morning ), Immediately on rising, confusion of the head; on waking, head heavy, etc.; after rising, pain in abdomen, etc.; in bed, urging to stool; cough; on rising, weakness, etc.; on waking, weariness, etc.
( Forenoon ), Pressure in stomach.
( Noon ), Pains in head; pain in elbow; while sleeping, twitching of legs.
( Afternoon ), Eructations; stitches through left chest; palpitation of heart; sticking in kidney region; chilliness.
( Evening ), Lips dry, etc.; bilious eructations; sticking in spleen, colic below navel; passage of flatus; colic; mucus in larynx; cough, etc.; oppression of chest ; drawing above wrist; heaviness, etc.
( Midnight ), Fulness, etc.; at stomach.
( After midnight ), On waking, heaviness in thighs.
( Open air ), Confusion of head; vertigo , etc.; nausea, etc.
( Ascending stairs ), Dyspnœa.
( Beer with bread ), Pains in forehead, etc.
( Bending body ), Pain within anus.
( After bread and butter ), Sick feeling.
( On coughing ), Soreness in abdomen.
( After dinner ), Pains in head; heartburn, etc.; griping; especially when lying down, palpitation; discomfort.
( While eating ), Tearing in abdomen.
( After eating ), Symptoms always aggravated; colic.
( During expiration ), Scraping in throat; burning in fauces.
( Walking ), Sticking in forehead; pains in abdomen, etc.; colic; stitches in anus; pains in great toe.
( During inspiration ), Sticking in chest.
( Deep inspiration ), Pains in walls of abdomen.
( Looking up ), Vertigo.
( Lying ), Pain causing nausea.
( After milk ), Nausea, etc.
( After moving about ), Pain in anus.
( On going out ), Twinging, etc., in umbilicus.
( Pressure ), Pains in walls of abdomen.
( On rising and while rising ), Rumbling in intestines, etc.
( In room ), Vision vanishes, etc.
( While sitting ), Desire to pass flatus; tension, etc., pains in upper abdomen; sticking on margin of foot; jerking in foot.
( Sitting with abdomen bent over ), Pain in umbilical region.
( Before every stool ), Griping in colon.
( After stool ), Scraping in anus.
( Touch ), Griping in intestines.
Amelioration.
( Eating gruel ), Pains in abdomen.
( Inspiration ), Burning in fauces.
( Rest ), Pain in forehead; pain within anus.

SUPPLEMENT: CROTON TIGLIUM. Authorities.

64 , M. Andral, Gaz. Med. (Bost. Med. and Surg. Journ., vol. vi, 1832, p. 194), effect of application to the skin of from 4 to 20 drops in more than thirty cases; 65 , Dr. Maudezin, Gaz. des Hôp., 1869, p. 290, a child, æt. six years, took all at once 3 grams of Croton oil in a cup of coffee; 66 , G. H. Snead, M.D., Rich. and Louis. Med. Journ., 1872, p. 651, Mrs. S. took two teaspoonfuls of Croton oil mixed with two parts of sweet oil.

The child was taken with the most acute pain in the epigastric region, followed by violent, extremely profuse vomiting for three-quarters of an hour. After this she fell into a profound sleep for a quarter of an hour, when she called for food. She had no more pain in the epigastrium or abdomen, and had only two profuse stools. Afterwards there was a fine vesicular eruption on the lips caused by contact of the oil; in other respects the child seemed well, 65.
Burning sensation in stomach and bowels; rapid and drastic purging (soon); pulse 150 and scarcely perceptible; entire surface bathed in cold, clammy sweat; countenance sunken; copious watery choleraic dejections every few minutes (after two hours), 66.
A few hours after the friction (supposing this to have been employed for some minutes) the patients experienced a smart tingling in the part. In some this sensation was transient; in others prolonged, but never to such and extent as to produce troublesome nervous disturbance; at the same time there appeared a great number of little red points, at the apices of which there were soon perceptible little pustules which, within from thirty to fifty hours, had become fully developed. Many of these became united, and there formed large patches filled with white opaque fluid. The eruption increased for three or four days, after which it remained stationary, and subsequently died away like small-pox. In some cases where the oil was applied to the face the eruption was more copious and intense than else where. 64.

Croton Tiglium