Opium

Papaver somniferum.

Natural order , Papaveraceæ.

Common names , Opium, Mohnsaft.

Preparation , Tincture of the gummy exudation from the unripe capsules.

Authorities. (Nos.

1 to 99 , from Hahnemann, R. A. M. L., 1, 278, with critical annotations in brackets, by Dr. Hughes.)

1 , Hahnemann; 2 , Cubitz; 3 , Gutmann; 4 , Schœnike; 5 , Stapf; 6 , Act. Nat. Cur., IV, Obs. 145 (observation by Hasenest); 7 , Eph. (not Act.) Nat. Cur., Cent. I, Obs. 54 (from a large dose of "Theriaca," given to a child of six weeks, observation by Hoyer); 8 , Æpli, Hufel. Journ., XXV, 3 (from mixture of opium and rhubarb, given to a baby for colic); 9 , Alibert (not accessible); 10 , Alpin, Med. Ægypt., IV, Cap. 1 (general statement as to Egyptian opium-eaters); 11 , Alston (Essays and Obervations, Edinb., V, 93, observations); 12 , Baglivi, Prax. Med., Lib. I, p. 65, from too many and too large doses (statement); 13 , Bard, Diss. de vir. Op., Edinb., 1765 (p. 15, experiment on self with 1 1/2-grain doses); 14 , Bauer, in Act. Nat. Cur., II (Obs. 93, observation); 15 , Bautzmann, Misc. Nat. Cur. Dec., II, Ann. 8 (Obs. 44, observation); 16 , Bellonius, Libr. 3, Obs. Cap., 15 (p. 431, from opium-eating); 17 , Berger, de vi opii rare facient (general statement from authors); 18 , Bergius, Mat. Med. (p. 458, general statement from authors); 18 a , Boerhaave, prælect. (general statement); 19 , Bohn, de officio med., p. 362 (symptoms not found); , Bonetus, Sepulcret. Anatom. lib. I, sect. 1, p. 214 (symptoms not found); , Borellus, Cen. 4, Obs. 57 (observation); , Büchner, diss. de Opio. Hal., 1748, § 45 (not accessible); , Büttner, Unterr. Ueber. d. Tœdtlichk. d. Wunden (p. 204, observation); , Charas, Pharm. Reg. Chym., C. 51 (symptoms not found); , Chardin, Voyage en Perse, Amst., 1771, Tom. IV, p. 203, 204 (statements as to opium-eaters); , Charvet (Act. de l'Opium, Paris, 1826, experiments with various doses); , Clerk (In. Essays and Obs., Edinb., III, 121, poisoning of a man by 20 grains); , Clauder, Eph. Nat. Cur., Dec. II, Ann. 5, Obs. 178 (experiment with an extract prepared with sulphuric acid); , Cocq, in Stalpaart v. d. Wiel, Observ., Cent. II, Obs. 41 (symptom not found); , Crumpe, Nature and Properties of Opium, 1793, [From the original, as quoted in Sharp Essays on Med., p. 15. -T. F. A.] effects of 1 grain of opium, taken in a teaspoonful of warm water, pulse 70, normal; , from same, a healthy man took same dose, ; , Crumpe, took 2 1/2 grains of Opium, pulse 70; , Delacroix, Journ. de Méd., XXXIX, 1773, p. 313, from 2 grains, in a clyster, taken by a woman; , Eph. Nat. Cur., Dec. II, Ann. 10, Obs. 80 (should be Misc. Nat. Cur., statement); , Ettmüller, Diss. de vir. Opii Diaphor., Lips., 1694, Cap. I, § 5 (general statement); , Freind, Opera, Tom. I, Emmenol, p. 139 (general statement); , Garcias ab Horto, Hist. Aromat., I, Cap. 4 (observation); , de Garter, Med. Dogm., Cap. I (not accessible); , Geoffroy, Mat. Med., II (general statement); , Grimm, Act. Nat. Cur., III, Obs. 19 (experiments on self, with grain i-iij); , Guiand (not accessible); , Haller, Prælect. in Bœrh. Inst., IV, p. 519 (general statement); , Haller, de Part. Corp. Viritab. et Sensib., Sect. 2 (not found); , Hamberger, Diss. de Opio, Jen., 1749, § 16 (a general statement, cited from Geoffroy); , Hargens, Hufel. Journ., IX, 2 (observation on a patient); , Hecquet, Réflexions sur l'usage de l'Opium, Paris, 1726, p. 184 (not accessible); , omitted; , de Hellwich, Bresl. Samml., 1702 (not accessible); , Hist. de l'Acad. des Sc., 1735 (not accessible); , Hoffmann, Diss. de op. Opeii, Hal., 1700 (general statement); , ibid., Diss. de Corr. Opii, Hal., 1702 (not accessible); , ibid., Med. Rat. Syst., II (p. 273, general statement); , Hufel. Journ., VIII, 4, p. 134 (not found); , Hunter, uber d. vener. Krankh., p. 640 (observations on patients); , Jœrdens, Hufel. Journ., XVII, 1 (observation on self when taking laudanum to procure sleep); , Jones, the Mysteries of Opium Revealed (observations); , Juncker and Böhmer, Diss. Sistens Casum. Matrone Largissimo usu Opii Tract., Hal., 1744 (not accessible); , Kämpfer, Amœn. exot. Fasc., III, Obs. 15 (observation on self in health); , Kilian, Med. Annal., 1800 (not accessible); , Knebel, Hufel. Journ., XXVI, 2 (p. 148, observation on a child with hooping-cough); , Lassus, Mem. de l'Inst. National des Sc. et Arts, Tom. II (from gr. 26, taken by a woman of sixty); , Leroux, Journ. de Méd. (from nearly a drachm, in a woman of fifty-one); , Levesque-blasource, Journ. de Méd., 1808 (vol. 16, pt. 1, p. 21-24, from large doses in a man); , Lindestolpe, de Venen., p. 591 (general statement); , Journ. Encyclop., I, pt. 2, p. 72, also Recueil period, p. 74 (observations and statements); , Martin, Vetensk. Acad. Handling, 1773, P. II, Nr. 7 (observation); , Matthai, Hufel. Journ., XI, 2 (observations on patients); , Manchart, Eph. Nat. Cur., Cent. I, Obs. 15 (from a grain of crude O. taken by self): , Mead, de Venen., in Op. D., II, p. 190, edit. Götting. (general statements); , Monno, Essays Phys. and Lit, vol. III (Art. 13, experiments on frogs); , Müller, Hufel. Journ., XVIII (p. 55, from a mixture of tinct. Thebaica and Hoffmann's anodyne, given for a nervous affection); , Murray, App. Med. II, p. 282 (general statement); , Muzell, Wahrn., II, p. 131 (from a mixture of Opium and Spr. Cornu cervi); , d'Outrepont (from a large dose taken by a woman eight months pregnant); , Ouwens, Noctes Hayanæ Vorr., p. 14 (from laudanum taken for spasms of legs); , Pitcairne, Diss. de Circul. in Animal., etc., also Element. Med. (observations); , Plater, Obs., Lib. I, p. 127 (not found); , Pyl, Aufsätze, Samml., I, p. 95 (from a large dose of the extract, in a man of fifty or sixty); , Rademacher, Hufel. Journ., IV, 3, p. 587 (from tinct. Thebaica given in dysentery); , Reineggs, in Blumenbach's Med. Bibl., I (an account of the effects of Opium-eating); , Renodæus, Mat. Med., Lib., I, sect. 13, Cap. 2 (statement); , Riedlin, lin. Med. Ann., IV, Decemb. Ob., 16 (observation); , de Ruef, App. ad Nova Acta Nat., Cur., V, p. 63 (general statement); , Saar, Reise n. d. Orient (statement as to use of O. by Chinese); , Sachs v. Lewenheim, Misc. Nat. Cur., Ann. 2, Obs. 69 (general statement); , Sauvages, Nosol. method, I, p. 847 (a drachm and a half of laudanum drunk by a boy of fifteen); , Schelhammer, Misc. Nat. Cur., Dec. II, Ann. V, Obs. 12 (from pills of styrax and Opium); , Schweickert, Hufel. Journ., VIII, 3 (not found); , Stalpaart, v. de. Wiel, Cent. II, Obs. 42 (from half a drachm of solid Opium); , Stentzelius, de Venen., I, § 46 (not accessible); , Stütz, Hufel. Journ. (X, 4, 35-7, from Opium given in a convulsive attack); , Van Swieten, Comment., I, p. 878 (general statements); , Thomassen a Thuessink, Diss. de Op., use in syphilitide, L. B., 1785 (not accessible); , Thompson, Diss. de Opio, p. 121 (observations and statements); , Tralles, de usu et abusu Opii (observations and statements); , Vermendois (not accessible); , Vicat, Plant. Vénén. de la Suisse, p. 226 (from overdose of laudanum mixed with amber and nitre. N.B. All the symptoms referred to Vicat belong to this case, which is in the work mentioned); , Waldschmid, Monita Med. Circa Opium, Marburg, 1679 (not accessible); , Ward, Neues Journ. d. Ausländ. Med.-Chir. Lit., IV, 1 (from external applications); , Wedel, Opiologia, p. 165 (not accessible); , Wepfer, de Apoplexia, p. 24 (not accessible); , Whytt (Essays, Phys. and Lit., II, 308, experiments on frogs), omitted, T. F. A.; , Willis, Pharm. Rat., p. 305 (observations and statements); , Young, treatise on Opium (observations and statements), ( to , Jörg's provings from Materialien, 1825, all provings with Opium combined with Magnesia, omitted); , Guntz, took 1 drop of tincture, afterwards 2, 4, 6 and 9 drops, and subsequently repeated doses of 2 to 18 drops; , same, took doses of 1/2 to 1 grain of crude Opium; , Kneschke, provings with tincture, doses of 1 to 9 drops; , Lippert, provings with tincture, 1 to 36 drops; , Otto, tincture, 2 to 4 drops; , Pienitz, tincture, 1 to 6-drop doses; , Siebenhaar, tincture, 1 to 12-drop doses; , Jörg, took tincture, 1 to 3-drop doses; , Edwd. Jörg, tincture, 1 to 2-drop doses; , Theo. Jörg, tincture, 1/2 to 2-drop doses; , Mrs. Ch., tincture, 1/2 to 2-drop doses; (Nos.

110 to 120 , Austrian provings, Zeit. des. Ver. Hom. Ærzt. Aust., 1862); 110 , Dr. Alb, effects of tincture, 5 drops, one dose; 110 a , same, subsequent proving, 25 drops of tincture; 111 , Dr. Bresslauer, provings with 30th and 12th dils., doses in the morning; 112 , Duditsch, proving with 30th and 12th dil.; 113 , Eidherr, provings with 1st dil., 4 to 24-drop doses; 113 a , same, tincture, 5 to 20-drop doses; 114 , Dr. Freud, tincture, 6-drop doses; 115 , Jenitschek, 1st dil., 3 to 15-drop doses; 115 a , same, tincture, 30-drop doses; 116 , Wm. Jenitschek, aged nine and a half years, 1st dil., 3 to 20-drop doses; 116 a , same, tincture, 2 to 20-drop doses; 117 , Dr. Schauer, tincture, 20 drops; 118 , Stern, tincture, 5 to 20-drop doses; 119 , Szontagh, tincture, 5 to 40-drop doses; 119 a , same, 1st trit., 12 to 12-grain doses; 120 , Tedesco, 6th dil., three times a day; 120 a , same, 1st dil., 5 to 25-drop doses; 120 b , same, tincture, daily doses of 5 to 30 drops; 121 , Smith, Med. Museum, 1763, a man in the habit of taking 3 drachms of O. daily, took 1 1/2 drachms morning and noon, also statement of general effect in same man; , Kennedy, Edinb. Med. and Surg. J., 1794, effects of 155 grains, in a man; , Pfundel, from Schlegel Materialien, 1800 (Frank's Mag., 3, 600, a man took 12 to 15 grains in beer); , Lassus, Med. and Phys. Journ., 1801, p. 491, effects of 36 grains of O. in a woman of fifty-six, death after eleven hours; , Schlegel, Materialien, 1801 (Frank's Mag., 3, 600), a physician took 1/2 an ounce in beer; , same, another man took 1 1/2 drachms in beer; , McKechnie, Edinb. Med. and Surg. Journ., 1811, p. 305, effects of an ounce of laudanum, in a woman aged twenty-eight; , Vincent, Thesis, 1816 (Wibmer), effects of a large dose; , Ward, Med. and Phys. Journ., 1802, p. 130, effects of inunction (in right leg and foot) of 2 drachms of tincture of Opium with olive oil; , same, repeated two days later in left leg; , Weber, Med. and Phys. J., 1803, p. 435, effects of single doses large enough to produce effects; , same, effects of 2 grains, in a young lady; , same, effects of 4-grain doses, in eight healthy men; , same, effects of 3-grain doses, in three men; , same, effects of 4 grains, given the next morning to two of the preceding cases; , Shephard, Med. and Phys. Journ., 1808, 1, p. 497, effects of 2 1/2 drachms of O.; , Kinnis, Edinb. Med. and Surg. J., 1818, effects of 1 1/2 ounce of laudanum, in a man; , Percival, Dubl. Hosp. Rep., 1818, 226, effects of 2 ounces ofcamphorated tincture of O., in a delicate old lady, antidoted by green tea; , Lond. Med. Repos., 1818, vol. 9, p. 525, effects of 3 ounces of tincture; , Polinieri, Bibl. Med., 1820 (Wibmer), effects of 2 grains, in a glass of wine; , Desruelles, Journ. Univers., 1820 (Frank's Mag., 4, 660), effects of 2 drachms; , Leigh, Med.-Chir. Rev., vol. 2, 1821, p. 888, effects of 30 and afterwards 90 drops of laudanum; , Richardson, Edin. Med. and Surg. J., 1821, p. 226, effects of 3 drachms, in a woman seven weeks after confinement; , Howison, Edin. M. and S. J., 1822, p. 49, effect of about 2 ounces of laudanum, in a girl aged eighteen; , same, effects of 1-2 ounces laudanum, in a girl aged seventeen; , Ross, Edin. M. and S. J., 1823, p. 247, effects of 2 ounces in laudanum in two doses, in a man; , Bost. Med. Intell., 1824, 1, 203, effects of about an ounce of tincture of Op., in a man; , same, vol. 2, p. 135, effects of an ounce in coffee, in a woman; , same, vol. 3, p. 132, 1825, effects of four teaspoonfuls of laudanum in a child of three years; , Gottel, Rust's Mag., 1825 (Frank's Mag., 1, 597), effects of fresh juice of a poppyhead, in a child four weeks old; , Olivier, Archiv. gén. de Méd., 1825 (Frank's Mag., 3, 299), effects of 1 1/2 ounce of laudanum, in a man; , Suchet, from Alibert, Eléments de Thérap. (Wibmer), effects of a teaspoonful of laudanum, in a child seventeen months old; , Kopp (Wibmer), effects of two poppyheads in milk, in a child aged six months; , Williams, Lancet, 1828, 2, 764, effects of a large dose, in a woman aged forty; , Lancet, 1828, 2, 254, effects of 2 ounces of laudanum, in a man; , Bally, Mem. Roy. Acad. of Med., 1828 (Frank's Mag., 4), effects of 20 grains, in a man; , Bardsley, Edin. M. and S. J., 1828, vol. 30, p. 306, effect of a large dose, in a man; , Edin. Med. and S. J., 1828, vol. 29, p. 450, from J. de Chim. Méd., effects of application of a poultice containing about an ounce of laudanum to an erysipelas; , Wibmer, experiments on self, took 1/4 grain first day, 1 grain second day, 2 grains third day; , Purkinje (Wibmer), took 5 grains; , Madden, Travels in Turkey (from Bost. M. and S. J., 1829, 2, 503), experiments on self; , Root, Lond. Med. Gaz., 1830, vol. 5, p. 703, effects of a large quantity, in an intemperate man; , Mart, Lancet, 1831, 1, 710, effects of habitual used of Opium, 1/2 drachm daily for fifteen years, in a woman; , same, habitual use in another woman; , same, habitual used in a man, aged sixty, who had use it thirty-five years; , same, habitual use in a man of forty, had taken 1 1/2 ounce of laudanum daily for ten years; , same, habitual use, in a woman aged fifty-five, who took 20 grainsdaily for fifteen years; she died of tuberculosis pulm.; , Werner, Rust's Mag., 1832 (Frank's Mag., 1, 597), effects of the juice of a poppyhead, in a girl aged seven; , Lancet, 1832, 1, 639, effects of 12 drops of laudanum with marshmallow, introduced into rectum after cauterization; , Strohl, Hufel. J., 1833 (Wibmer), effects of poppyheads, in a boy; , Oppenheim, Hamb., 1833 (Wibmer), effects of sleeping near a field of poppies in blossom; , same, took 7 grains of O. as an experiment; , Lancet, 5, 218, effects of an ounce of laudanum, in a woman of twenty-two; , Lancet, 6, 124, effects of 2 ounces of tincture, in a woman; , omitted; , Lancet, 10, p. 732, effects of six drachms of laudanum, in a young woman; , Lancet, 1833, 1, 268, effects of about an ounce of laudanum, in a man; , Thomson, Bost. Med. and S. J., 1835, p. 133, habitual use of laudanum, in a woman; , Montault, Journ. Univers., 1836, effects of about 5 drachms of laudanum in a woman (Frank's Mag., 4, 660); , Yound, Lond. Med. Gaz., 1834, vol. 14, p. 655, effects of about an ounce of laudanum, in a pregnant woman; , Christison, Lancet, 1836, 1, 631, effects of about 2 or 3 drops of laudanum, in an infant three days old; death in twenty-four hours; , Lancet, 1836, 1, 271, effects of about 2 ounces of laudanum, in a man; death after nine hours; , Bost. Med. and S. J., 1834, p. 284, effects of about an ounce of Opium, in a man; , Kiles, Lancet, 1837, 1, 304, 4 drops of laudanum, in a child nine months old; death in nine hours; , Bullock, Lond. Med. Gaz., 1837, p. 264, 1 ounce of laudanum, in a girl aged twenty-one; , same, same dose in another girl; , Sigmund, Bost. M. and S. J., 1837, p. 101, effects of habitual use among the Turks; , same, effects of 4 grains, in divided doses; , Smith, Am. J. M. Sc., 1837, p. 450 (Med.-Chir. Trans., vol. 20), effects in a woman; , Koch, Rust's Mag., 1837, 15 drops of laudanum Sydenhami, in a child aged four weeks; , same, effects of a poppyhead in milk, in a child with hiccough; , Lancet, 1838, 1, 389, 20 drops of laudanum daily for six days; no effects till after last dose, in a woman accustomed to take it for uterine pain; , Bost. M. and S. J., 1838, p. 128, general effects of opium-eating; , Am. J. Med. Sc., 1838 (J. de Chim. Méd.), effects of application of a cerate containing 15 drops of laudanum to an excoriation in a fold of skin; , Hubbard, Bost. M. and S. J., 1838, p. 31, effects of a drachm of tincture, in a child six months old; , Strecker, A. H. Z., 12, 134, proving, dose of 1 grain; , Semple, Lancet, 1840, 2, 186, effects of 1 1/2 ounce, in a girl aged nineteen; , Harrison, Lancet, 1840, effects of about six dessertspoonfuls, in a woman aged thirty-two; , Boisragon, Lond. Med. Gaz., 1840, vol. 25, p. 878, effects of a teaspoonful of laudanum, in a child under two years; , Vanderkeere, 2 drachms of laudanum, in a child aged thirteen months; , Williams, Lancet, 1840, 2, 661, effects of 1 1/2 ounce of tincture, in a woman; , Erichsen, Lond. Med. Gaz., 1840, vol. 28, p. 390, effects of 1 ounce, in a girl aged twenty-two; , Shipman, Am. J. Med. Sc., 1840, vol. 26, p. 508, effects of a wineglassful of laudanum, in a woman eighty years old, recovery; , Hygeia, 13, 393, effects of injection of 20 drops of tincture, for spasms of uterus; , Pupke, Med. Zeit. Ver. Preus., 1841, effects of a poppyhead, in a child aged four; , Choune, Lancet, 1841, 2, p. 705, effects or more than an ounce, in a man who had been drinking; , Hill, Lancet, 1841, 1, 820, effects of smoking O., in a Chinaman; , Hensley, Lancet, 1841, 1, 88, effects of 1/2 ounce, repeated after a quarter of an hour; , Cowper, Lond. and Ed. Month. J., 1841, 1, 71, a person took 2 1/2 ounces of liq. op. sedativ. (death after an hour and twenty minutes); , Buck, Bost. M. and S. J., 24, p. 126, a woman, aged twenty-two, took 1 ounce; , omitted; , Morris, Am. J. Med. Sc., 1842, p. 148, effects of some laudanum with castor oil, in a child four months old; , G. H. Smith, Lancet, 1842, p. 707, opium-smoking among Chinese; , Walth, A. H. Z., 22, 160, experiments, first took 1/2 a grain after each meal, then 1 grain, and afterwards 2 and 4 grains; , Everest, Lancet, 1842, p. 758, effects of 12 minims of tincture of Op., in a child two days old, death after fourteen hours; , McCune Smith, Lond. Med. Gaz., 1843, 1, 878, effects of habitual use of laudanum, in a woman aged twenty-four; , same, habitual, use, in a man; , same, habitual use; , same, habitual use; , Russell, Lond. Med. Gaz., 1843, 1, 924, 12 drops of laudanum, in a child two months old; , Pharm. J., 1843, vol. 3, p. 261, effects of laudanum, in two children; , Taylor, Guy's Hosp. Rep., 1844, 2, 32, effects of 1 1/4 grain of opium, divided into five doses, in a girl aged five and a half, death thirty-seven hours after first dose; , Gaz. des Höp., 1845, (Écho de la Frontière), effects of unripe poppyheads, in three children; , Sharkey, Ranking's Abst., 1846, effect of two pills, each containing 1 1/4 grain of ext. Op., in a man; , James, Lancet, 1847, 1, 639, effects of an ounce of laudanum, in a woman; , Barry, Ranking's Abst., 1847, 25 minims of laudanum, in a child aged nine months; , Lancet, 1848, 2, 696, 2 ounces of laudanum, in a woman; , Iliff, Lancet, 1849, 2, 874, an indefinite amount of laudanum, in a boy aged seventeen; , same, an indefinite amount, in a woman; , Wooten, Bost. M. and S. J., 1849, p. 133 (from Southern Med. and S. J.), effects of 1 drop of laudanum, in a child five days old; , Stevens, Bost. M. and S. J., 1849, p. 120, effects of repeated use of laudanum when children (now aged twenty-three, twenty, and eighteen); , "Confessions of an English Opium-eater," Prov. M. and S. J., 1848; , Little, Month. J. of Med. Sc., 1850, p. 524, general effects of Opium-smoking; , Wright, Am. J. Med. Sc., 1851, p. 540, effects of about 10 grains on self; , Boecker, from Bernardi and Lœffler, 1851 (Frank's Mag., 4), experiments, effects of increasing doses, in a healthy man; , same, a man aged forty-seven took 3 grams twice first day, 4 grams twice second day, 5 grams three times third day, same twice fourth day, 5 grams thrice and 6 grams once fifth day, 5 grams thrice sixth day, 6 grams thrice seventh day, 6 grams four times eighth day, 8 grams four times ninth day, 8 grams four times and 9 grams once tenth day; , same, subsequent proving, took 6 grams; , Herpath, Lancet, 1852, 1, 303, a teaspoonful of laudanum, in an infant nine days old; , Deguise, Month. J. of Med. Sc., 1852, 14, p. 88, effects of 200 minims of laudanum in a clyster; , Woodson, Am. J. Med. Sc., 1852, p. 573, effects of "Bateman's drops" (Opium and Camphd. tinct. op.), in a child five days old; , Kirk, Lancet, 1853, 1, 80, effects of a few drops of laudanum, in a child; , Smith, Lancet, 1854, 1, 419, effect of 1/20th grain Op., in a child five days old; , Anderson, Month. J. Med. Sc., 1854, p. 377, 2 drachms laudanum, three drachms more after one hour and a half, in a woman; , Bullock, Am. J. Med. Sc., 1854, p. 575, about 2 ounces of laudanum, in an intemperate man; , Hodges, Bost. M. and S. J., 1856, p. 23, 1 ounce of laudanum in a girl of fifteen years; , Blanc, Rev. de Thér. Méd.-Chir., 1857 (S. J., 97-37), effects of three injections of Sydenham's laudanum; , Gibbs, Lancet, 1857, 2, 80, effect of 1 1/2 ounce of laudanum in a man aged seventy-two; , Corbett, Lancet, 1857, 2, 220, 30 minims of tincture, in a child one day old; , Channing, Bost. M. and S. J., 1857, vol. 56, p. 449, from three to six teaspoonfuls of laudanum, in a man; , Bost. M. and S. J., vol. 56, p. 526, 1857, effects of drinking some laudanum, in a child aged six; , Wood, Bost. M. and S. J., 1857, vol. 57, p. 78, effects of a few drops of "paregoric" (probably laudanum), in a child aged nine months; , Chamberlin, Bost. M. and S. J., 1857, vol. 57, p. 357, about 1 1/2 grain of Op., in a child six days old; , Pharm. Journ., 1857, vol. 16, p. 195, effects of laudanum, in a woman aged twenty-four; , O'Rorke, Gaz. des Hôp., 1858, a spoonful of Sydenham's laudanum, in a child seven months old; , Schützenberger, Gaz. des Strasburg, 1858, 40 grams of laudanum, in a woman; , Murray, Edinb. Med. J., 1858, 72 drops of l., in a child one year old; , same, 1 drachm of solution of muriate of Morph., in a child seventeen months old; , Mushet, Med. Times and Gaz., 1858, p. 292, Opium, in a child of three months; , Gallagher, Am. J. Med. Sc., 1858, p. 559, 2 ounces of tincture, in a woman; , Jackson, Am. J. Med. Sc., 1859, p. 75, a tablespoonful of laudanum, in a youth of nineteen; , Lister, Br. Med. J., 1859, p. 692, 2 drachms of laudanum, in a woman of thirty; , Am. J. Med. Sc., 1859, p. 281, repeated effects of Op. in slight uterine inflammation; , Crook, Br. Med. J., 1860, p. 341, 40 minims of l., in a child twenty-two days old; , Pearson, Med. Times and Gaz., 1860, 2, p. 72, an indefinite amount of l., in an infant eight weeks old; and , Campbell, Bost. M. and S. J., 1860, p. 101, effects of 1 1/2 ounce of l., in a man; , Andrews, Pharm. J., 1860, p. 387, fatal effect of a black draught containing liq. Op.; , Pharm. J., 1860, p. 287, effects of a piece of Op. as large as a pin's head, in a child five weeks old; , Duchek, Wien Med. Woch.-Bl, 1861 (S. J., 113, 165), a man took a large amount of tinct. Op.; , Beaupoil, J. de Chim. Méd., 1861 (S. J., 110, 294), three-fourths of a poppyhead, in a child; , Maschka, Prag. Vjs., 1861, effects of 1 ounce of tincture; , Duncan, Lancet, 1861, 1, 637, effects of 1 1/2 ounce of l., in a woman; , Pharm. J., 1861, p. 46, effect of a lare dose, in a woman; , Murray, Braithwaite's Ret. of Med., 1862, 2, 266 (Austral. Med. J.), effects of 1 1/2 ounce of l., in a man aged fifty; , Duncan, Am. J. Med. Sc., 1862, p. 272, 2 ounces of l., in a woman; , Lee, Ranking's Abst., 1862, effects of Op., in a child two years old; , Ellis, Lancet, 1863, p. 126, 1/2 ounce, in a girl four and a half years old; , Pharm. J., 1863, p. 186, a teaspoonful of l., in a child six years old; , same, p. 136, fatal dose of Op. in a man; , Taylor, Guy's Hosp. Rep., 1865, effects of 1 1/2 ounce of laudanum, in a girl aged eleven and a half; , omitted; , O'Sullivan, Dublin Quart. J. of Med. Sc., 1865, p. 221, effects of 1 scruple, in a child twelve weeks old; , Walley, Lancet, 1866, p. 35, habitual use of l., for fourteen years; , Radcliffe, Lancet, 1868, p. 312, 3 drachms of l., in a woman aged thirty nine; , same, two tablespoonfuls of l., in a woman of sixty; , Finlay, Lancet, 1868, p. 664, effect of an indefinite amount of l. (probably used as an enema for pain in abdomen); , Ogle, St. Geo. Hosp. Rep., 1868, p. 222, about 2 ounces of l., in a man; , same, an indefinite amount, in a man; , same, in another man; , Young, Phil. M. and S. Rep., 1869, vol. 20, p. 157, about 2 ounces of tinct. Op., after a drunken spree; , Farnsworth, Phil. M. and S. Rep., 1869, p. 87, about 30 grains, in a man; , Hemecourt, West. Hom. Obs., 1869, p. 89, about 1/2 ounce of l., in a girl; , Dobbie, Br. Med. J., 1870, p. 33, 2 ounces of l., in an insane woman; , Olivier, Gaz. des Hôp., 1871, effects of 30 grams of the tincture, on account of erections after circumcision; , Spooner, Trans. Hom. Med. Soc. St. of N. Y., 1871, 2 ounces of l. with 6 grains of Morphia, in milk; , Murdock, Med. Rec., 6, 343, effect of 1 1/2 ounce of l., in a woman of thirty; , Johnson, Med. Times and Gaz., 1872, 2, 268, 4 drachms of ext. of Op., in a woman; , same, 3 drachms of extract, in a man; , same, 1 1/2 drachm of Op., in a man; , same, 3 drachms of extract, in a woman aged twenty-four; , same, 2 drachms of extract, in a man; , same, 2 drachms of extract, in a woman of twenty-nine; , same, 1 drachm of extract, in a man; , same, 4 drachms of extract, in a woman; , same, 2 drachms of extract, in a man; , same, 1 1/2 drachm of extract, in a woman of thirty-seven; , same, 3 drachms of extract, in a man; , same, Med. Times and Gaz., 1873, 10 drachms of extract, in a girl aged sixteen (death in nine hours); , same, 3 drachms of extract, in a man, death in seven hours and a half; , same, an unknown quantity, in a woman; , same, 2 drachms of extract, in a woman of thirty-six; , same, 1/2 ounce of extract, in a woman of twenty-seven; , Walker, Am. J. Med. Sc., 1872, p. 283, tincture of Op. (equal to 6 or 8 grains of pulv. Op.), in a girl of fifteen; , Chatarion, Gaz. des Hôp., 1873, effects of 20 grains of Sydenham's laudanum; , Pharm. J., 1873, p. 138, effects of a large dose of laudanum, in one habituated to Opium; , Price, Hahn. Month., 1873, p. 474, effects of discontinuing the use of the "black drop." that had been used for pain in an ulcer; , Stockman, 3 ounces of laudanum, in a man, vomited and recovered, but next day took 2 1/2 ounces, Phil. M. and S. J., 31, 164; , Hartley, Lancet, 1873, p. 684, 1/2 ounce of laudanum; , Parrish, Phil. M. and S. Rep., 1873, p. 343, effects of habitual use of Op., as suppository; , Pehell, Phil. Med. Times and Gaz., 1873, p. 134, effects of 1 1/2 fluid ounce of l., in a young woman; , Hart, Am. Hom. Obs., 1873, p. 31, about an ounce of laudanum, in a child; , Sharp, Essays on Med., 1874, p. 724, experiments with 1st dil. and with tincture; , Heaton, Med. Times and Gaz., 1875, p. 413, large dose of laudanum, in a man; , Clark, Med. Times and Gaz., 1875, p. 185, a large dose of l., in a man; , Pharm. J., 3d ser., vol. 5, p. 179, a large dose of laudanum; , Sharp, Essay on Med., No. 32, experiments a man took 1 drop of 1st cent. dil. of tinct. of Op., night and morning, for ten days; , same, subsequent proving, 5 drops, night and morning; , same, subsequent proving, pulse 72, took one dose of 10 drops of tincture; , same, subsequently, pulse 54, took 6 drops of tincture; , same, Dr. Sharp, took 1 drop of tincture; , same, a man, well, pulse 68, took 5 drops of tincture; , Cameron, Am. J. Hom. Mat. Med., 1876, p. 251, proving by inhaling Op., 60th dil.; , C. Wesselhœft, N. A. J. of Hom., 1876, p. 17, habitual use of Op., in a man aged fifty; , Fitzsimmons, Toledo Med. and Surg. Journ., May, 1877, p. 134, effects of about 2 drachms of laudanum, in a child two years old; , Skae, Edin. M. and S. J., 1840, p. 151, effects of 2 drachms of laudanum, in a man; , Toogood, Prov. Med. and S. Journ., 1841, p. 129, effects of 10 drachms of laudanum, in a woman (recovery); , Ryan, Lancet, 1845, p. 476, effects of 1/2 drachm of laudanum, in a man; , omitted; , Lyman, Am. J. of Med. Sc., 1854, p. 383, effects of an ounce of laudanum, in a woman, death in three-quarters of an hour; , Jackson, Am. J. of Med. Sc., 1854, p. 385, effects of 2 drachms of Op., in a woman; , Cleveland, Med. Times and Gaz., 1855, p. 82, a man took 2 ounces of liquor Op.; , Sloane, Med. Times and Gaz., 1855, p. 445, effects of 1/2 ounce of laudanum, in a man; , Slayter, Lancet, 1862, p. 326, laudanum, in a woman; , Ludlow, Brit. Med. Journ., 1866, p. 15, an overdose of laudanum, in a man; , Bowstead, Lancet, 1873, p. 468, effects of 8 ounces of tinct. Op., in a woman; , Taylor, Med. Jurisp., 1, p. 349, an ounce and a half of laudanum, in awoman; , Daniel Wilson, Inaugural Dissertation on the Morbid Effects of Op., Phil., 1803, 2 drachms of Opium, in a man; , ibid., an ounce of laudanum, in a woman; , ibid., same, in a man; , ibid., effects of habitual use of 50 to 90 grains of Opium, in a man; , ibid., another case; , ibid., Baron de Toth, observations among the Turks.

MIND

• Emotional.
• Delirium.
• *Delirium, 71, 169.
• Sometimes delirium, 348.
• Delirium and rage, 17.
• Raging delirium, with distortion of the mouth, 60 . [Caused by applying Opium to the temples. -Hahnemann.]
• Violent delirium, with red face, glistening eyes, and great physical activity, 62.*
• Furious delirium (fourth day), 267.
• He rolls about the floor in delirium, burning with anger, threatens, does not recognize his friends, with swollen head and face, reddish-blue swollen lips, with protruding, inflamed eyes, 90.
• While delirious he talked about all sorts of things with open eyes , and afterwards remembered them only as in a dream, 63.*
• Talked of his business, cast up columns of figures, and started up at any noise (after three hours); much better (after six hours), 289. [10.]
• *Her laudanum was left off for three days, and, in addition to the other symptoms, she appeared to see the most frightful animals and other objects, 177.
• Delirium lasted twenty-four hours, 191.
• His joyfulness and mental bliss increased until he became irrational and delirious, 90 . [From large doses. -Hahnemann.]
• Evidently delirious, but, by persevering in our endeavors, he became capable of giving very pertinent answers, though he uttered them with much labor and difficulty (after half an hour), 122.
• Made delirious attempts to resist any treatment, but soon relapsed into unconsciousness, 321.
• Delirium with the spasms, 290.
• He said many disconnected things, and pointed with his fingers to masked people who seemed to approach him . At one time he broke into loud laughter; at another he started up in affright on account of fancied swords em, who threatened to stab him; became angry if any one argued with him or thought him delirious; however, he blamed himself while in delirium for his folly, 90 . [From Opium given fro dysentery-like diarrhœa. -Hahnemann. Render "fechtern" swordsmen. -Hughes.]*

Theriaki (opium-eaters) represent as the acme of happiness, 192.

• It causes for a time forgetfulness of the troubles of the soul, and produces ecstasy and refreshing quiet of mind, 90.
• The effects upon her spirits were most exhilarating; she felt lively and cheerful, and could accomplish almost any amount of household work, 281.
• Uncommonly merry and much inclined to noise, 182.
• So exhilarated as to grow careless of occupation and rather inclined to indulge in an excess of gayety (after a short time), 141. [100.]
• Produced an enlivening effect which enabled him to prosecute his study, 141.
• Very good humor (second day), 115.
• At first ecstasy followed by sadness and despondency, 25.
• Contentment, 1.
• Taciturnity, 18.
• He became taciturn (after the smallest dose), 1.
• Excessive anxiety, 68.
• Unusual sensation of anxiety (after two hours), 115a.
• Anxiety, 203.
• Anxiety, 74 . [Omit Tralles. -Hughes.] [110.]
• Transient attacks of anxiety, with short, oppressed respiration and trembling of the arms and hands, 2.
• Melancholy, 18.
• Despondency (fifth day), 113a.
• On waking, depression, 206.
• Depression of spirits, in the afternoon (after three drops), 6.
• Depression of spirits (eighth day), 118 ; (after three-quarters of an hour), 129a.
• Pale and dispirited, next morning, 160.
• Sadness, 1, 117.
• Sad mood (first and second days), 235.
• Sullen mood, 38.* [120.]
• Hopeless, morose mood, fretfulness (after eight, and twelve hours), 1.
• Very morose, angry at everything without reason (fourth day), 235.
• Lamentations and howling during the first hours, 1.

HEAD

• Confusion and Vertigo.
• Confusion of the head, with a sensation of dry heat in the eyes and inclination to close the eyes, without sleepiness, together with a sensation as though he had watched the previous night, 2.
• Head confused , as after intoxicating drinks, 118.* [280.]
• Confusion of the head, after sleep, 50.
• Vertigo, 27, 62, 67, 90, 99 ; (sixth day), 113 ; (eleventh day), 115, 171 ; (second, third, fourth, fifth, seventh, ninth, and tenth days), 235, 235a.
• Violent vertigo obliges him to lie down, 62.
• Violent vertigo (after 4 drops), 103.
• Vertigo; some intoxication, 170.
• Vertigo and dulness of the head , transient (after 4 drops), 103.*
• Vertigo; was scarcely able to keep upright; even while sitting it seemed difficult to hold up the head (after 16 drops), 102.
• Vertigo, on looking to the right or left (looking straight ahead, on bending the head forward, did not cause vertigo), (after half an hour), 113a.
• Vertigo, with swaying back and forth of the body, 116a.
• Vertigo, as if everything were turning about with him in a circle, 82. [290.]
• Vertigo, caused by stooping (after twenty hours), 1.
• Vertigo, and stupefaction of the head, 62.*
• Slight vertigo (after two hours and three-quarters); relieved after vomiting (after three hours and a half), 30b.
• Vertigo, with numbness of limbs (after five minutes), 191.
• Dizziness, with vanishing of thoughts (after 4 drops), 163.
• Dizziness, with confusion of the head, 99.
• Dizzy, anxious, irrational, 90.
• Dizzy, as if intoxicated, after waking from sleep (first day), .

EYE

• Eyes very red; pupils dilated, with staring look (after forty-eight hours), 167. [450.]
• Eyes rotated upward under brows (after four hours), 236.
• Eyes turned upward under the upper eyelids, 183.
• Eye prominent and motionless (second day), 290.
• Eyes open, turned upward, 73.
• Eyes wide open, 222.
• Eyes open, and altogether distorted, 92 . [Original revised by Hughes.]
• Eyes distorted, 149.
• Eyes fixed (after two hours), 276.
• Eyes fixed; pupils contracted, and altogether unaffected by light (after one hour and three-quarters), 185.
• Eyes dark and glassy, 165. [460.]
• Glassy, deep-sunken eyes, 192.
• Eyes glistening, 155.
• Eyes glistening, sparkling, 62.
• Eyes sparkled, 126.
• Staring look, 203.
• He stares at the bystanders with watery eyes; does not know what he is looking at, and cannot recognize individuals, 75.
• Eyes staring, with excessive lustre, 66.
• Eyes wild and staring (after one hour), 127.
• Eyes became full and sparkling, 206.
• Eyes look heavy (after twenty minutes), 129. [470.]
• Eyes glassy and lack lustre, 162.
• Heavy, uneasy eyes (after 4 to 6 grains), 130.
• Eyes heavy and languid (second day), 144.
• Dull, unimpressive eye, 232.
• Eyes dim (after two hours), 175.
• Eye lost its expression, 182.
• Eyes sunk, 232.
• Eyes sunk, and often glassy (after six hours), 127.
• Eyes sealed up, or dropping rheum, 232.
• Eyes only half closed; pupils dilated, insensible, 54. [480.]
• Eyes half open, drawn forcibly upward and outward; pupils contracted, did not dilate when light was removed, .

EAR

• Pressure toward the external meatus auditorius, 119a.
• Jerking within the ears, first in the left, then in the right, 112.
• Throbbing in both ears, 112.
• Hearing.
• Hearing more acute than usual (after half an hour), 113a.
• It was very remarkable that, when the torpor and comatose heaviness were as such a height, he appeared to have almost no command of any of his muscles, nor the smallest perception of what was passing around him; his hearing was nevertheless remarkably acute, and he repeatedly requested that we would no speak louder than usual, saying that it disturbed him exceedingly to hear the loud talking, 122.
• Hearing somewhat indistinct, as in slight intoxication, 119a.
• Difficulty of hearing in the left ear, lasting four minutes (after three hours), 110a.
• Hearing so deficient that she could hardly detect the voice of any one who spoke; yet her own voice sounded most disagreeably loud to her, 177.
• Difficulty of hearing, 269. [600.]
• The hearing remained weaker for some time after the proving, 235a.
• Violent roaring in the ears (sixth day), 235.*
• Great roaring in the ears, in the evening while sitting still, 119.
• Roaring in the ears, 116, 119, 119a.
• Some roaring in the ears, 119.
• Dull roaring in the ears after eating (after four hours), 26.
• Ringing in the ears, 67, 99 ; (eleventh day), 115.
• Disagreeable humming in the ears, when talking or whistling, 119a.
• Humming in the ears (very soon), 26.

NOSE

• One symptom never failed to accompany any attempt to renounce Opium, viz., violent sternutation. This now became exceedingly troublesome, sometimes lasting for two hours at a time, and recurring at least two or three times a day, 231. [610.]
• (Violent coryza, with some cough), 114 . [Apparently the result of taking cold from the damp weather, as in other respects I was perfectly well. -Freud.]
• Bloody liquid exudes from the nose and mouth during the convulsions, 151.
• Copious secretion of mucus from the nose, 232.
• Frothy mucus ejected from the nares (after four hours), 275.
• A large quantity of frothy-looking fluid tinged with arterial blood escaped from the nose (after seven hours and three-quarters), 306.
• Stoppage of the nose like stopped catarrh, in a warm room, after walking in the open air, 3.
• Great dryness in the nose, the whole afternoon and evening (after 2 drops), 106.
• Sense of smell of impaired that she could perceive no pungency in snuff, 177.

FACE

• Face swollen, skin hot and dry, tongue white, hoarseness, respiration very much impeded, spitting of blood, 99 . [From Opium taken for incipient cold when in a plethoric state. S. 666, 1271, 1286, 1451, 2250 alll belong to this. -Hughes.]
• Swelling of the face, 151. [620.]
• Face greatly swollen, and had an unmeaning ghastly expression, 335.
• Face swollen, violet-colored, like the rest of the body, 244.
• Spasmodic motions of the facial muscles (after seven days), 58.
• Spasm of the facial muscles, 55 . [With stupor. -Hughes.]
• Muscles of the face affected with spasm, and those of the limbs with convulsions, 157.
• Convulsive trembling of the facial muscles, lips, and tongue, 8.
• Face altered, eyes haggard, cheeks furrowed, pale, 292.
• Features distorted, taciturn, with open eyes, 8.
• Features distorted, 149.*
• Face purple and the features distorted (after fifteen minutes), 208. [630.]
• Face bloated, red, and rather livid, 181.*
• Countenance bloated (after one hour and three-quarters), 185.
• Face bloated and dark, 228.
• Face much congested, 316.
• Distended veins in the face, 75.
• Face full, and the skin of it having a smooth glassy appearance (second day), 144.
• Gave a new air of life and brightness to his face, 121.
• Wild and fierce-looking (after a quarter of an hour), 140.
• Look horrid (second day), 296.
• Fixed look, 290. [640.]
• All the muscles of the face seem relaxed, which gives the face a stupid expression; the lower lip is inclined to hang down relaxed, the nostrils are widely opened, and the upper lid can be raised only with difficulty, 4.
• He looks as though he had not slept enough, or had been revelling all night, with sunken, blinking eyes, 2.
• Countenance presented that peculiar vacancy or want of definite expression which is characteristic of the influence of Opium, .

MOUTH

• Teeth. [750.]
• Looseness of the teeth, 1.
• Toothache, 1.
• Fine gnawing pain in the nerves of the teeth (after eight hours), 1.
• Gum.
• Gums eaten away, so that the teeth stood bare to the roots, 14.
• Tongue.
• Rapid tremulous motion of the tongue, 151.
• Tongue in constant motion, 268.
• Tongue thrust forcibly backward and upward against the palate, 211.
• Tongue and lips purple (after one hour), 263.*
• When asked to put out her tongue she did so tremblingly, which was coated with a brown fur, 281.
• Tongue immovable, 156. [760.]
• Paralysis of the tongue, 75.
• Tongue thick, with difficult speech, 203.
• Tongue black, 58.*
• Coated tongue (eleventh day), 115, 116.
• Tongue thickly coated (second day), 115a.
• Tongue coated, with a sticky, pasty taste (eighth and ninth days), 115.
• Tongue white, 38, 99, 232.*
• Tongue coated yellow (second day), 161.
• Tongue thinly coated with brown fur (second day), 155.
• Tongue dry (third day), 184, 232 ; (second day), 235, 273. [770.]
• Dryness of the tongue, palate, and fauces, without inclination to drink, 2.
• Sensation of dryness in the anterior portion of the tongue, without thirst, in the morning, 1.
• Tongue dry, red on its edges, and covered on the centre with a coat of thick white substance (second day), 290.
• Tongue, as far as the fauces, completely dry, . [This dryness of the mouth was noticed on waking from sleep, when I found myself lying on my back, quite contrary to habit, with open mouth. I had apparently lain in this position for a long time. -A. L. B.]

THROAT. [830.]

• Rattled in throat, and immediately after breathed deeply (after five hours), 219.
• Râles in the throat, 292.
• Pain in the throat on swallowing (fifth day), 235.
• Choking in the throat, followed by eructations (third day), 235.
• An anxious sensation of constriction in the throat, 203.
• Sensation as if a tight band were about the throat, associated with a stupid feeling in the head (after 18 drops), 100.
• Distressing sensation of constriction or strangulation in the throat; the patient thought that she would die, with inability to swallow, 203.
• Remarkable dryness or burning in the throat, which urges them to repeat the Opium-smoking, 212.
• Parched throat, 232.
• Dryness of the throat posteriorly, 18. [840.]
• Dryness in the throat and on the tongue, 33, 67.
• Throat dry (after two days), 283.
• Pharynx and Fauces.
• Sense of constriction about the pharynx (second day), 284.
• Fauces red (second day), 273.
• Scraping and constriction in the fauces, immediately, 110.
• Sensation of dryness in the fauces and larynx, 233.
• Scraping raw sensation in the fauces, 120a.
• Dryness of the fauces (second day), 235.
• Œsophagus.
• Cramp in the œsophagus always on swallowing, 119.
• A kind of cramp in the œsophagus, that made swallowing, even water, difficult, 119. [850.]
• Cramp in the œsophagus during and after swallowing, 119a.
• Swallowing.
• Inability to swallow, 8, 221, 222, 229, 240 , etc.
• Inability to swallow, with dryness of the throat, 203.

STOMACH

• Appetite.
• Appetite increased, 1.
• Decided increase of appetite, 325.
• A considerable increase of appetite, 324.
• Appetite for supper better than usual, 129.
• Ravenous hunger; distension and distress in the stomach after eating, 63 . [Said by the reporter to be a common occurrence with him. -Hughes.]
• He never felt so hungry in his life; he ate his breakfast greedily, and was soon relieved of every disagreeable sensation, 129a.
• Frequent paroxysms of ravenous hunger, at times with a flat taste in the mouth (after three, and several hours), 1.
• Ravenous hunger, 53. [870.]
• Ravenous hunger, with dread of food, 38.
• Excessive hunger, with great weakness, 94.
• Sensation of hunger, which, on taking food, changed to a sensation of emptiness and pressure in the stomach (third day), 113.
• Feeling of emptiness in the stomach and an unusual sensation of hunger about 11 A.M. (after six hours); although I ate as much or more dinner than usual, at 1 P.M., this sensation of emptiness continued until after 3 o'clock, during which time there were frequent eructations of air (first day); sensation of emptiness in the stomach and decided hunger by 10 A.M., in order to assuage which I took two eggs, some bread, and a glass of beer, which, however, did not suffice; at noon I ate a hearty meal, as yesterday, but the sensation of hunger and emptiness was not relieved; it only disappeared after two hours of itself (second day), 110a.
• Capricious appetite, 232.
• Appetite either destroyed or depraved, sweetmeats and sugar being the articles that are most relished, 212.
• Appetite bad (after four days), 155.
• Want of appetite for food and drink, 67.
• Appetite diminished (after 4 drops), 100 ; (fourth day), 235.
• Appetite diminished, though food had a natural taste (second day), 235. [880.]
• Appetite extinguished, and in place of it craving for one thing only, and that is, for another draught of the poison, which soothes but for the moment, 232.
• , , , , , , , , .*

[Revised by Hughes.]

• Acute throbbing, with visible rising and sinking, rhythmical with the pulse, of the full stomach, while lying down, after dinner; it made lying on the back intolerable; was obliged to rise and walk about, after which it gradually disappeared (thirteenth day), 115.
• Fulness of the stomach, 50.
• Rumbling in the stomach and abdomen (seventh day), 235.
• Complains of tenderness and pressure in the epigastric region, and says she feels a pain there on inspiration (third day), 135.
• Great tenderness on pressure at the epigastrium (after five days), 201.
• Stomach hot, and painful on the slightest pressure, 155.
• The stomach would not tolerate more than a quarter a week, 281.
• The stomach is insensible to emetics, 67.
• Considerable indigestion, after an early dinner, at 1.30 (after six hours), 329. [980.]
• Digestion becomes much impaired, 232.
• Slow digestion, 98.
• Makes digestion slow and diminishes the appetite, 37.
• Disturbs digestion; causes in the stomach a sensation of heaviness and compression, and an indescribable distress in the pit of the stomach, 33.
• Causes weakness of the stomach, 1, 40.
• Accumulation of flatus in the stomach and intestines, 67.*
• Sensation of emptiness in the stomach, not relieved by a glass of water; this distressing sensation was relieved for about twenty minutes after breakfast, but it was renewed and continued with only slight interruptions during the whole day, though I ate frequently (fifth day), 113a.
• Uncomfortable feeling in the stomach, somewhat like that after a purge, extending into the ileum, but not causing actual colic (after 1/2 drop), 109.
• Sensation of streaming warmth, commencing in the epigastric region and extending over the whole body (third day), 113.
• Coldness in the stomach (fifth day), 235. [990.]
• Feeling of constriction in the stomach, with constipation, 116a.*
• Sensation of constriction in the stomach (first day), .

ABDOMEN

• Hypochondria.
• Pain in the hypochondria, especially in the right, 38.
• Pressive pain in the left hypochondrium, 116.
• Painful sensations in the region of the spleen and the back; also affecting the thorax (after 1 drop), 108.
• Umbilicus and Sides.
• Colic in the region of the umbilicus, followed after a few hours by a diarrhœa-like stool (after 8 drops), 100.
• Acute cutting pain in the region of the umbilicus, soon followed by desire for stool, with an evacuation that was not hard (after 3 drops), 106.
• Dull pressive pain in the umbilical region (seventh day), 235.
• Pain in the umbilical region caused by slight pressure (fifth day), 235. [1020.]
• Sensation as of a weight in the abdomen, in the umbilical region, with anxiety; sensation of flushes of internal heat, and stupefaction of the head (after one hour), 1.
• Stitches in the left side of the abdomen, even when not breathing (after three hours), 1.
• Stitch in the left flank (fifth day), 235.
• General Abdomen.
• The abdomen became distended, especially in the umbilical region, 31.
• Abdomen distended, 31, 90, 190 ; (after 2 drops), 108 ; (after forty-eight hours), 167.*
• Abdomen distended, tympanitic (fifth day), 235.*
• Abdomen tense, distended, 151.*
• Abdomen very hard and tense, 199.
• Abdomen hard, 155.
• Abdomen hard swollen and sensitive to touch, 280.* [1030.]
• Rumbling in the abdomen (fifth day), 235.*
• Rumbling and moving about in the intestines (second day), 235.
• (first day), .*

RECTUM AND ANUS

• Pressive pain in the rectum as from hæmorrhoidal congestion, aggravated by touching the anus, 119. [1090.]
• Sensation as if the passage through the rectum were closed on making exertion at stool, 1.
• Sensation as though the anus were suddenly and spasmodically constricted; not relieved by making an effort, as in urging to stool; external touch caused the most acute burning pain; this sensation lasted about ten minutes, disappeared gradually, but was renewed upon every touch (first day), 113.
• Excessive pressing-distending pain in the rectum (after four, and six hours), 1.
• Anus spasmodically closed during the colics, with very difficult emission of flatus (ninth day), 236.*
• Spasmodic closure of the anus (eighth and previous days), 235.
• Persistent tickling in the anus, ending with itching (second day), 113.
• Increased ineffectual efforts to evacuate the bowels (after 1 drop), 109.
• Dulness or difficulty of evacuation, 98 . [Ibid.]
• Two or three evacuations of the bowels, with unusual desire following the first dose (1 drop); after 2 drops the bowel seemed indolent and as if it could not evacuate its contents; in the evening there was an evacuation, not hard, 106.

STOOL

• Diarrhœa.
• Persistent diarrhœa; the discharges are not frequent, four or five times in twenty-four hours, whitish, pasty, and causing excessive burning in the anus, that frequently lasts a quarter of an hour after the movement (after twelve to twenty-four hours), 195.* [1100.]
• Diarrhœa comes on, relieved only by fresh indulgence, and dysentery sometimes supervenes, 232.
• Bilious diarrhœa, attended with severe pain extending from the right hypochondrium to the umbilicus (third day), 254.
• Diarrhœa for two days (after sixteen days), 155.
• Watery diarrhœa, 15 . [as soon as she took Opium for toothache. -Hahnemann.]
• Opium causes diarrhœa at times (secondary action), 41.
• Evacuations passed involuntarily, 286.
• Involuntary evacuation of stool and urine, 149, 341.*
• Slight diarrhœa (third day), 278.
• Occasional diarrhœa, 278.
• Bowels slightly relaxed, 281. [1110.]
• The bowels, which are usually costive, became freer, continuing so for many days, 330.
• Diarrhœa-like stool, preceded by colic (after eighteen hours), 100.
• Diarrhœa-like stool in the afternoon (after 6 drops taken in the morning), 100.
• Diarrhœa-like evacuation of the bowels, preceded by colic (after 12 drops), 100.
• The first part of the stool hard and difficult, the last part diarrhœa-like (after about a week); two days after he was awakened about 5 A.M. by necessity to go to stool, followed by a copious, pasty, dark-colored, almost odorless evacuation, without pain, 119.
• Stool in the morning, followed by a second after eating, and again after an hour (third day); in the evening (fifth day); followed by constipation, 118.
• Thin stool, 120.
• Stool thin, frothy, profuse, followed by great relief (second morning), 115a.
• Three thin stools, with some dragging and burning in the anus, in the evening (fourth day), 115a.
• Very thin stool in the evening (third day), . [1120.]

URINARY ORGANS

• Kidneys and Bladder.
• Among affections of the kidneys Bright's disease is not uncommon, 232.
• A kind of tenesmus in the bladder; when beginning to urinate he was always obliged to wait a long time on account of twitching of the sphincter vesicæ; this symptom always occurred on urinating, 119. [1170.]
• *The bladder became distended, but not having power to expel its contents, a catheter was introduced and gave great relief (second day); great pain and difficulty in expelling urine, and also pain in the bladder when it becomes distended (third day); passes a small quantity of urine at a time, with difficulty and pain (fifth day); micturition still painful, and accompanied by a sensation of bearing down (tenth day); pain and difficulty in voiding urine are increased, and from straining in the attempt has forced her womb down, which gives much additional pain (fourteenth day); had received a kick in hypogastric region some time ago, and had difficulty in passing urine at different times since, 153.
• *It weakens the expulsive power of the bladder, 40a.
• Urethra.
• Some spasm on urinating in the morning; on the two following days there was acute constriction of the urethra as far as the bladder; after urinating the pain gradually disappeared; on the third day blood was passed with the urine; this continued three days, then gradually disappeared; the spasmodic constriction of the urethra continued, after which it gradually disappeared, 111 . [There was no visible alteration in the orifice of the urethra, except a very slight redness or irritation. Had never experienced such urinary symptoms before in my whole life. -BRESSLAUER.]
• The patient complained of pain as from need to urinate without being able to accomplish it, 150.*
• Sensation on evacuating urine as if the passage through the urethra were closed, 1.
• Micturition.
• Frequent involuntary micturition, 267.
• Emission of urine violent (after second day), 155.
• Desire to urinate, with difficult discharge (ninth day), 235.
• Micturition much more frequent than usual, always scanty, and evacuated easily, 235a.
• Micturition difficult, , ; (one case), . [1180.]

Urine 286.

Normal While taking Opium Amount, Water, Solid constituents, Urea, Uric acid, Inorganic salts, Phosphates, Phosphate of lime, Phosphate of mangnesia, Volatile salts and extractives, 1485.900 1435.887 50.513 11.693 0.091 23.906 1.113 0.726 0.387 14.823 1637.500 1590.089 47.461 11.059 0.000 21.986 0.547 0.334 0.218 14.416

Urine, 235.

First five days.

Second five days.

Amount, Water, Solid constituents, Urea, Uric acid, Inorganic salts, Phosphates, Phosphate of lime, Phosphate of mangnesia, Volatile salts and extractives, 1691.600 1642.842 48.758 10.197 0.000 24.313 0.618 0.388 0.230 14.248 1583.400 1537.287 46.168 11.921 0.000 19.658 0.476 0.280 0.196 14.584

SEXUAL ORGANS

• In both sexes the procreative power is greatly lessened, and in those women who, nevertheless, do bear children the secretion of milk is defective. The influence of the habit on the generative functions is, indeed, so decided that, were it not for fresh arrivals from China and other parts of the East, the population of Singapore would very soon be seriously diminished, 232.
• The sexual organs, at first preternaturally excitable, gradually loose their tone, 232. [1230.]
• All opium-smokers become impotent at a much earlier period of life than others, 212.
• Male.
• Cutting pain in genitals when passing water (after seven days), 155.
• Male impotency, 35, 75.
• Impotency, 26, 192.
• Gradu impotentiæ (after 4 to 6 grains), 130.
• Excessive erections, 24.
• Violent erections (after two hours and a half), 112.
• Frequent erections in sleep, at night, 119.
• Erections during sleep, and after waking, impotency, 84.
• Erection during sleep, and after waking, complete impotency, 84. [1240.]
• It excites sexual desire, with erections, emissions, and lascivious dreams, 67.
• Amorous ecstasy; erections for twenty-four hours; lascivious dreams; nightly emissions, 90.
• Excitement of sexual desire; erections; nightly emissions, 37.
• Nightly emissions (first night), 1.
• Amorous fancies; emissions at night, 45.
• Excitement of sexual desire, 1, 95.
• Immoderate lasciviousness, 79.
• It is considered to enervate and weaken sexual desire, 95.
• In some, excitement; in others, diminution of sexual desire, 80.
• No inclination for coition during the whole proving, 235a. [1250.]
• Sexual desire indolent, 76.
• It cools the desire for coition, 75.

RESPIRATORY ORGANS

• Spasms of the respiratory muscles at times, 263.
• Larynx.
• Tickling in the larynx, with violent dry racking cough, lasting ten minutes; both the dryness and cough relieved by a glass of water; they however, returned after a quarter of an hour, with so great violence that tears came to the eyes; again relieved by drinking water , after which he fell asleep for over two hours, and was again awakened by paroxysms of cough, which, however, were less violent and accompanied by some expectoration of mucus, at 3 A.M. (after five hours and a half). Tickling in the larynx, causing dry cough, which lasted more than six minutes, with lachrymation, relieved by drinking water (this cough was the same as that which woke him from sleep at 3.45 A.M.), (after 3.15 P.M., second day).*

*Tickling in the larynx and dry cough, soon after 2 A.M., that ceased after five or six minutes, without drinking water (second night). Dry cough, with tickling and scraping in the larynx woke me at 3 A.M.; this time it lasted scarcely five minutes (fourth night), 110.

• Bronchi.
• Bronchial irritation and expectoration (after eight hours), 223.
• Voice.
• Voice harsh and hollow, 165.
• Voice deep and harsh, 166.
• Voice gruff, 162.
• Voice quivering, 232. [1270.]
• Extreme hoarseness, 99.
• Hoarseness, 99, 189.
• Hoarseness, with a very dry mouth and white tongue, 38.
• Hoarseness, as if caused by mucus in the trachea, 1.
• Cough and Expectoration.
• Paroxysms of violent dry cough, followed by yawning and a sudden loud cry (after thirty-six hours), 1.
• Dry cough, with tickling and scraping in the larynx, woke him from sleep very early in the morning (second day), 110a.*
• Cough hollow, very dry, immediately after a dose, soon disappearing, 1.
• Cough on swallowing, 31.
• Cough caused by swallowing a liquid, 31.
• Cough aggravated after eating, 1. [1280.]
• During the whole period of years through which I had taken Opium, I had never once caught cold, not even the slightest cough, but now a violent cold attacked me, and a cough soon after, 231.
• Cough, with scanty tenacious expectoration, with much rattling in the chest (fifth day), 267.*
• Expectoration of large quantities of mucus and pus, 162.
• Constant expectoration of mucus, 162.
• Expectorates frothy mucus, 62.
• Expectoration of thick bloody mucus, 62.
• Expectoration of blood, 99.
• It restrains the expectoration of blood and evacuation of stool, 89.
• Rapid respiration, 22 ; (first day), 235.

CHEST

• Lungs somewhat oppressed, 135, 345. [1440.]
• Oppression of the chest, 203 ; (first, third, fifth, and seventh days), 235, 235a.
• Indescribable oppression in the chest, 232.
• Oppression of the chest, making respiration difficult, and lasting a quarter of an hour (after 12 drops), 100.
• Anxiety, with contraction and tightness of the chest, 62.
• Heaviness in the chest, with frequent need of taking a deep breath, with at times gasping for air; the clothes were too tight; the beat of the heart could not be felt (after two hours), 115a.
• Pressure in the thorax frequently occurring, causing hacking cough, which always relieved it for a short time (after 3 drops), 106.
• Pain in the chest (fourth day), 267.
• Violent pain in the chest (tenth day), 235, 235a.
• Very violent pain in the chest, lasting through the afternoon, and making respiration difficult (sixth day), 235.
• Pain in the chest, and a cough, which has continued ever since, five or six years (after the discontinuance of the drug), 177. [1450.]
• Tensive pain beneath the short ribs, along the attachment of the diaphragm, while breathing, 1.
• Constriction of the chest, as if it were stiff; difficult respiration, 99.
• Recurring stitches starting from within the thorax and extending outward, especially towards the right scapula (after 3 drops), 106.
• He feels heat in the chest (perceptible to himself), 16.
• Front and Sides.
• Constrictive (pinching) pain in the sternum and back, felt on motion, 1.
• Drawing-tearing pain in the side of the chest, 1.
• Excessive pressive pain in the right side of the chest, even when not breathing, with stitches in the same side during inspiration (after one hour), 1.

HEART AND PULSE

• Heart.
• Violent beating of the heart, 155, 203.
• Pulsations of heart accelerated (after fifteen minutes), 191.
• Circulation increased in rapidity, with a sensation of heat, 67. [1460.]
• The imperfect and irregular action of the heart became now more alarming than ever, and was more so when in a reclining than in a sitting posture (after five hours), 263.
• Heart's sound exceedingly weak, 263.
• Heart's action healthy, but feeble, varying with the respiration, 322.
• Heart's action could not be felt, 286.
• Heart's action suspended, 173.
• Anxiety about the heart and restlessness (after two hours), 99 . [Constantly renewed doses of Opium was the only palliative, even then for only a short time. -Hahnemann.]
• Sensation of faintness and failing about the heart, seizing him as often as he was dropping asleep, 99 . [Revised by Hughes.]
• Burning, as from glowing coals, in the heart, so that she thought that she would die, 52.
• Painful stitch in the region of the heart (fourth day), 235.
• Pulse.
• Pulse between 70 and 80, never above 84; in strength it was as remarkable for its healthy character as for its number (after seventeen hours), 247. [1470.]
• Pulse regular (after three hours); 102, weak (after fourteen hours), 296.
• In every instance the pulse has been quickened, and sometimes rendered sensibly fuller, in two or three minutes, e. g ., from 66 to 68, and from 70 to 76; after a longer or shorter interval, e. g ., in from five minutes to an hour, determined by the dose, the beats return to what they were at the beginning, and sometimes afterwards descend a little below this; the manifest effect, in all these experiments, is increase of frequency, and often of fulness also, 320.
• Pulse accelerated, full, and hard, 242.
• Acceleration of the pulse by 10 beats (soon after 25 drops), 119.
• Accelerated pulse, 171, 213, .

NECK AND BACK

• Great swelling and violent pulsation in the veins of the neck, 269.
• The back was stiff and straightened (a kind of tonic spasm), (between one and two hours), 1.
• Bending of the spine, frequently to such a degree as to assume a circular form, 192.
• The back was curved like an arch, from the violent trembling motion of all the limbs , that irritates all the nerves, 52.*
• Back painful (after one hour), 129a. [1630.]
• Drawing-tearing pain in the back, 1.
• Sensation of heat, alternating with coldness, along the spine (after half an hour), 113.
• Sensation as if there were pressure inward in the back and in the thorax up to the nape of the neck; the muscles and vessels seem contracted (after 3 drops), 106.
• Pressive pain between the tip of the right scapula and the posterior wall of the thorax (after 2 drops), 106.
• Pains in the dorsal muscles, at times extending into the thorax (after 2 drops), 106.
• Pain in lumbar region (after five days), 201.

EXTREMITIES

• Trembling of the hands and feet (tenth day), 118.
• Tremulous motion of all the limbs, 52.*
• Convulsive trembling of the limbs, 8.
• Trembling of the upper and lower extremities (sixth day), 235. [1640.]
• Spasmodic trembling of the limbs, 36.
• Limbs agitated by a nervous trembling, 290.
• Clonic spasms of the extremities, 267.
• Involuntary motions of the arms, fingers, and toes, 177.
• General spasms of extremities (after three hours), 229.
• A good deal of tremor of the various limbs, 286.
• Tremors in the limbs, 177.
• Convulsive movements of the extremities (after two hours), 219.
• Nails quite purple, 343.
• Limbs drawn up, 277. [1650.]
• The limbs lie immovable and remain wherever they are placed, 54.
• Limbs immovable, 168.
• Joints flexible (after six hours), 124.
• Limbs flaccid; unable to walk (after four hours), 201.
• All the limbs quite flaccid, and would remain wherever placed, 286.
• Limbs flaccid, 287.
• Relaxation of the limbs, and weakness, 41.
• Limbs relaxed and the body felt quite flaccid (after four hours), 275.
• Muscles of limbs relaxed (after eleven hours), 240 ; (after one hour and a half), 257.
• The limbs hang down relaxed (after forty-eight hours), 167. [1660.]
• Increased immobility of the limbs, 82.
• Limbs powerless (after fourteen hours), 298 ; (after two hours and a half), 302 ; (after six hours), 303 ; (after six hours and three-quarters), 306.
• Weakness of the upper and lower extremities, 119.
• Weariness in the legs and forearms, .

SUPERIOR EXTREMITIES

• Superior extremities shook violently, 164.
• Arm. [1680.]
• Automatic motions of the arms, 139.
• Attacks of trembling in the left arm (after three hours), 1.
• A convulsive motion, back and forth, in one or the other arm, 1.
• Arms hung motionless by her side (after two hours), 196.
• Some twitching of the arms, 174.
• The left arm is paralyzed (after forty-eight hours), 58 . [Revised by Hughes.]
• Feeling of numbness, extending from the left shoulder to the tips of the fingers, most severe on the palmar surface of the hand, thumb, and little finger, lasting six minutes, returning after twenty minutes, though less severe, and lasting only four minutes (after six hours), 110a.
• Drawing and tearing, now in the right, now in the left forearm, in the evening (seventh day), 118.
• Hand.
• Tremors in my hands (after two hours and three-quarters), 30b.
• Trembling of the hands, 88, 292.* [1690.]
• Hands of a purple color, 156.
• Hands livid (after eighteen hours), 226.
• Transient twitching in the hands (tenth day), 118.
• Numbness and sensation of swelling in the hands and forearms (second day), 282.*
• Touch so much affected that she could not execute any needle-work, 177.
• Fingers.
• Fingers blue, 286.
• Fingers and wrists occasionally jerked by spasmodic twitchings of the tendons, 284.
• Sensation of numbness in the left little and ring fingers, extending from the second joints to the tips of the fingers; it felt as though the fingers had been constricted for a long time, a sensation lasting only about four minutes, and disappearing after rubbing with the other hand, in the evening (second day), 110.
• A sudden drawing-tearing pain in the second joint of the right ring finger, aggravated by motion relieved by rest, lasting ten minutes, and gradually disappearing and extending above the wrist to the head of the radius, where it lasted for more than two hours (second day), .

INFERIOR EXTREMITIES. [1700.]

• Lower extremities very much flexed and cold (after three hours), 280.
• Trembling of the lower extremities (ninth and tenth days), 235.
• Trembling, especially of the lower limbs and about the lumbar region (first day), 235.
• Stiffness in legs (soon), 251.
• Legs stiff and with difficulty separated, 228.
• Stumbling gait (first, fourth, and tenth days), 235.
• Weakness of the lower extremities, 203.
• Lame gait, 192.
• Heaviness and weariness of the legs; his gait became stumbling, so that though he made but a few visits he was a weary as after a long journey on foot (second day), 110.
• Sensation of weariness in the lower extremities, 117. [1710.]
• Weariness of the lower extremities, especially of the knee-joints (eighth day), 235.
• Violent pains in the knee and hip-joints, which became so excruciating that I could neither sit nor lie, once (after 8 to 10 grains daily for a fortnight); removed by 8 grains in two pills, 130.
• Long-continued sensation of numbness and prickling in the left lower extremity, occurring after sitting only a short time, and not relieved by walking about (after two hours), 112.
• Crawling in the lower extremities, 235a.
• Thigh.
• Trembling of the thighs (second day), 235.
• Creeping shivering on the anterior surface of the right thigh, extending down to the knee, lasting a few seconds; after a quarter of an hour it commenced in the nape of the neck, and extended down the back to the sacrum, lasting only a few moments, without subsequent heat, disturbance of the circulation, or thirst, at 6.30 P.M. (first day), 110a.
• Drawing on the outer side of the right thigh (within ten minutes), 112.
• Tensive pain in the flexor muscles of both thighs, extending to the hollows of the knees, lasting only twelve minutes, in the forenoon (second day), 110.
• Rheumatic pain in the thighs (after 1 drop), 106.
• Sensation as if some liquid were moving up and down in the left thigh (first day), 235.
• [1720.]

GENERALITIES

• Strong convulsions, which affected the muscles of the trunk and extremities to such a degree as to make him as stiff as a frozen corpse; these spasms would continue from ten to fifteen minutes at a time, and then partially relax for two or three minutes, recurring several times (after fourteen hours); ceased altogether, a warm perspiration breaking out over the body (after fifteen hours and a half), 202.
• Frightful convulsions (after a quarter of an hour), 140.
• Frightful convulsions, with terrible pains, 128.
• Frightful convulsions and images before the eyes, 203.
• General convulsions (after two hours), 151 ; (after three hours), 211, 315. [1750.]
• Convulsions, 83 , [From large doses. -Hahnemann.] 87.*
• Convulsions (soon), 140, 150 ; (after five or six hours), 194, 199 ; (after three hours), 211, 199, 222 ; (after one hour), 288.
• Immediately attacked with a convulsive fit and died, 223.
• Convulsions and death (after five hours and a half), 310.
• Convulsions, with screaming, bending the head backward, at times opisthotonos, 178.
• Convulsions become stronger; the patient utters plaintive groans and tears everything within her reach; bites her hands and arms; four persons are necessary to keep her in bed, 290.
• Convulsions of the extremities and face (after nine hours); death (after nine hours and a half), 309.
• The fits were almost continual (second day), 290.
• After rousing her to give a dose of tincture of belladonna, there was an almost convulsive struggle of resistance, attended by violent excitement, and followed by sudden and complete collapse; entire cessation of respiration; pulse barely perceptible; face pale; lips livid; pupils unchanged and eyes rolled upward and outward, to the extreme limits of their orbits (after four hours and a quarter); relieved by injection of atropia, 318.
• Occasional convulsions, 193. [1760.]
• Convulsive twitches in the muscles, especially of the abdominal extremities, .

SKIN

• Surface of body pale, and covered with profuse perspiration (after four hours), 294.
• Pale (after seven hours), 249 ; (after half an hour), 262, 321.
• Surface of body pallid and contracted, 183.
• Skin livid, 243.
• Great lividity of the skin, particularly of the extremities, 246.
• Color of the skin pale and bluish, 38. [1990.]
• Skin of extremities and face blue (after four hours), 236.
• Blue color of the skin, especially of the genitals, 8 . [During the opisthotonos of S. 1773. -Hughes.]
• The cyanosis became very intense, and more extended than before (third day), 267.
• Cyanosis of the lips, tips of the fingers and toes, 267.
• Blue spots here and there over the body (after fifteen hours), 46.
• Redness of the whole body, 49.
• Skin of a red and inflamed color (he being a fair man, the son of a native of Persia), and all the veins, even to the minutest branches, were uncommonly distended, and had the appearance of being stuffed and gorged with their contents (after half an hour), 122.
• Congestion of the surface, especially about the neck and chest, increased, 339.
• Redness and itching of the skin, 37.
• Red spots on the cheeks, that are pale, 62. [2000.]
• Skin dry, rough, and of a dirty color, 163.
• Skin dry, parched, of a sunburnt color, 165.
• Skin dry to touch and shrivelly, and of a tawny color, 162.
• Skin brown, 166.
• Skin resembled leather, 164.
• Almost black, 265.
• It irritates the skin, removes the hair, and causes itching, 51.
• It removes the hair, causes itching, corrodes the skin, and draws blisters, 37.
• When applied to the skin as a plaster it causes great heat and pain, draws blisters, irritates the skin, and occasions mortification, 18a.

SLEEP

• Sleepiness.
• Yawning twice (after half an hour), 111.
• Yawning frequently repeated (after a few minutes), 111 ; (fifth day), 113.
• Yawning for a quarter of an hour, with pain in the joints of the jaws as if they would break, 5. [2040.]
• Slight drowsiness (after eleven hours), 245.
• *Drowsiness (after twenty minutes), 129 ; (after three-quarters of an hour), 129a ; (after two hours, two cases), 132, 220 ; (after a few minutes), 258 , etc.
• Drowsiness with the headache (after two hours), 30b.*
• Very drowsy (after five hours), 303.
• Constant drowsiness (after two hours), 312.
• Very drowsy, but easily roused up and able to walk about (after five hours and twenty minutes), 309.
• Very drowsy all day, 131.
• Extreme languor and drowsiness supervened, which threatened a deep and perhaps fatal sleep, 332.
• Great disposition to drowsiness (first day), 14.*
• Extreme drowsiness, amounting almost to sopor, 183.* [2050.]
• Exceedingly drowsy (after two hours), 196, 336.*
• Unusually drowsy (after half an hour); exhibited a peculiar facility forgoing to sleep in any possible position (after four hours), 233.
• She soon became very drowsy; she could be aroused by shaking and loud speaking, and then knew every one around her, looking at them with a half-intoxicated expression, understanding all that was said to her (after two hours and a half); could not be aroused by shaking or loud speaking (after six hours and three-quarters); more easily aroused, but instantly falls asleep again (after application of electro-magnetism), (after eight hours and a quarter); now rose up to the sitting posture, and got off the couch to walk across the room, supported by two persons, looking about her with an alarmed and bewildered expression, but apparently not recognizing any one; she was, however, sufficiently awake to drink a cup of strong coffee, taking the cup in her hand (after nine hours and a quarter), .

FEVER

• Chilliness.
• Chilliness immediately, in the evening, in bed, after which, as soon as she fell asleep, she broke into sweat, which was very profuse about the head, 1.
• He complains of chilliness, 75, 98.
• Chilliness over the abdomen, with dryness of the mouth, without desire for drink, 1. [2170.]
• Chilliness in the back, 1.
• Chilliness in the back, with suppressed, scarcely perceptible pulse, 82.
• Body cold (second day), 290 ; (after one hour), 319.*
• Cold and clammy (after seven hours), 258.
• Cold and weak (second day), 201.
• Cold and pulseless (after four hours), 236.
• Cold and lifeless (after five hours and a half), 143.
• Complains of being affected with a greater degree and a different kind of coldness to any he ever experienced before (after one hour), 129a.
• Complains of being cold (after twenty minutes); continues, and is accompanied with disagreeable sensations (after fifty minutes); still complains of being cold (after one hundred and twenty minutes), 129.
• Coldness, with stupefaction, 25. [2180.]
• Cold and shivery (after half an hour); skin feels cold (after half an hour); complains much of being cold all over, but particularly his feet (after three-quarters of an hour), 129a.
• Inclined to shiver, 75.
• Temperature greatly diminished, 244.
• Diminished warmth, 1.
• At first (according to the thermometer) diminished warmth, afterwards increased perspiration, 61.
• Surface of body cold and livid, 287, 340.
• Surface cold (after six hours and a half), 278.
• Surface of body cold and bluish (after one hour and a half), 257.
• Surface of body cold, 181 ; (after two hours), 184 ; (after one hour and three-quarters), 185, , etc.

CONDITIONS

• Aggravation.
• ( Toward morning ), Cold chill.
• ( Morning ), Pale and dispirited; on awaking, headache; dryness in anterior portion of tongue; bitter taste; colic, followed by diarrhœic stool; 5 A.M., urging to stool, with pasty evacuation; stool 8 A.M., tenacious yellowish-brown stool; dry cough and scraping in larynx; on awaking, pain in limbs and loins; gnawing pain in bones; bathed in perspiration; on rising, indolent; could not rouse himself; during sleep, sweat all over; 8 A.M., sleepiness.
• ( Forenoon ), 8 A.M., confused feeling in head; while reading, dimness of vision; 10 and 11 A.M., emptiness in stomach and sensation of hunger; pulse accelerated; pain in flexor muscles of both thighs.
• ( Noon ), No appetite.
• ( Afternoon ), Depression of spirits; inability and disinclination for work; tearing pain in occiput; griping in abdomen; diarrhœa-like stool; 2.30 P.M., tenacious yellowish-brown stool; constipation; copious emission of urine; pain in chest; perspiration over the whole body; strong perspiration.
• ( Afternoon and evening ), Headache; dryness in nose.
• ( Evening ), Pressive headache in left side of vertex and forehead; headache in occiput; burning sensation in eyes; while sitting still, roaring in ears; three thin stools, with burning in anus; thin stool; 6 P.M., hard brown stool, with great exertion; hard evacuation, with difficulty; copious yellow urine; drawing and tearing in forearm; numbness in left little finger; itching on the legs; unable to fall asleep; in bed, chilliness; burning heat in face.
• ( Night ), Weeping; headache and heat; griping in abdomen, followed by emission of flatus; 9 to 12 P.M., liquid stools; in asleep, erections; 2, 3, and 3.45 A.M., tickling in larynx, with cough; sleep restless; desire to slumber; sleepiness; easy and great perspiration.
• ( About midnight ), Awakened by oppression of chest; liquid stool; profuse perspiration.
• ( Midnight ), Rumbling in abdomen; desire for stool; burning in rectum; watery evacuation.
• ( After midnight ), Evacuation of large quantity of urine.
• ( Open air ), Eyes seem moist.
• ( On awaking ), From a nap, feeling of intoxication; headache and stupefaction; languid and stupid expression of countenance; from a dose, nausea; breathing heavy and oppressed; from a nap, difficult micturition.

SUPPLEMENT: OPIUM. Authorities. ( 351 to 353 , from Franklin Scott, Inaug. Diss., Philad., 1803, p. 18); 351 , gave Mr. J. A., æt. twenty-three years, 40 drops of tincture; 352 , I took 2 grains, rubbed down, with a little water; 353 , Mrs. H. took 6 drachms of tincture; 354 , Dr. Dufresne, Bib. Hom., vol. i, 1833, p. 227; 355 , J. B. Biddle, M.D., South. Med. and Surg. Journ., July, 1851, p. 427, a woman took 2 fluid ounces of Laudanum; 356 , A. Hadden, M.D., Amer. Med. Times, vol. i, 1860, p. 149, Mary McD., æt. twenty-eight years, took a dose of Laudanum; 357 , H. J. Horton, M.D., Med. and Surg. Reporter, vol. xv, 1866, p. 225, Mr. E. H., æt. thirty years, took 3 ounces of Opium; 358 , same, ibid., vol. xiv, p. 336, a child, two weeks old, took 6 drops of Laudanum; 359 , Henry Gibbons, M.D., Pacific Med. and Surg. Journ., 1868, p. 163, Mrs. --- swallowed a gill of brandy, and immediately after 1/2 an ounce of Laudanum; 360 , J. E. O'Brien, M.D., Chicago Med. Journ., vol, xxvi, 1869, p. 720, Emmy C., æt. two years, swallowed 13 pills of gum Opium, each containing about 1/4 grain; 361 , F. W. Campbell, M.D., Canada Med. Journ., vol. vi, 1870, p. 62, A. B., æt. thirty-two years, took about 2 ounces of Laudanum; 362 , J. B. Chaggon, M.D., ibid., p. 409, Mr. A. G. took same quantity; 363 , S. W. Morrison, M.D., Philad. Med. Times, November, 1875, p. 106, a child, æt. four weeks, took an indefinite amount; 364 , J. C. Morse, M.D., Pacific Med. and Surg. Journ., 1876, p. 56, a man swallowed between 40 and 70 grains of Opium; 365 , omitted; 366 , C. H. Morfit, M.D., Phil. Med. and Surg. Rep., 1877 (2), p. 466, poisoning from swallowing 1/2 ounce of Laudanum; 367 , Wm. T. Plant, M.D., New York Med. Rec., vol. xii, 1877, p. 717, a man, while intoxicated, took 1 ounce of Laudanum, and died; , Dr. Janvrin, Amer. Journ. of Obstet., vol. xi, 1877, p. 780, a child æt. five weeks, took 10 drops of Squibb's liq. Opii. com.; , T. G. Nasmyth, M. B., Edinb. Med. Journ., December, 1878, p. 505, a woman swallowed about 12 drachms of Laudanum, and died in thirty-six hours; , F. A. Southain, Brit. Med. Journ., 1878 (1), p. 824, a man, æt. thirty-eight years, took a quantity of Laudanum; , North Carolina Med. Journ., 1879, p. 65, Bettie R., æt. thirty years, swallowed upwards of 1 1/2 fluid ounces of officinal tincture of Opium; , Dr. Miclucho Maclay, Chemist and Druggist (Nature, vol. xix, 1879, p. 492), observations of Dr. Clouth.

MIND

• In the forenoon of the second day her mind was very much disturbed at intervals and by paroxysms; during one of these she would leap out of bed, and notwithstanding all opposition made by the nurse, would run downstairs and escape from the doors. These exertions would exhaust her strength, and before she could get far would become faint, fall down, and beg to be carried to her bed; she would then be composed for a time, till seized with a second paroxysm. These were repeated several times during the day, 353. [2300.]
• Hallucinations, 366.
• The sleep which he had that night was not natural; he passed the night in some jactitation, attended with delirium and frightful dreams, 351.
• Exhilaration of spirits (after forty-five minutes), 351, 352.
• A sensation which he compared to intoxication (after thirty minutes); had subsided considerably (after sixty minutes), 351.
• The stupor and lethargy were so great that he went to bed at 9 o'clock (after three hours and a quarter), 351.
• Stupor, 352, 353, 360.
• Stupid, livid, and unable to stand, 367.
• Unconscious, 355, 363, 368.
• Perfect insensibility; he could not be roused in the slightest degree by rough handling or loud shouting (after three hours), 361.
• Insensible and snoring loudly (after two hours), 354. [2310.]
• Deep coma, 359, 369 , etc.

HEAD

• Vertigo (after thirty minutes), 351.
• Vertigo, much worse on trying to walk (after two hours), 352.
• Whenever an attempt was made to walk I staggered a little, and felt as if intoxicated with wine (after five hours), 352.
• Turgescence in the head (after ten minutes), 351.
• Sensations of turgescence in the head (after forty minutes), 352.
• Pain in the head (after two hours), 353.
• Pain in the head and over the eyes (second morning), 352.
• At 10 A.M. the pain in the head increased, attended with a sensation of throbbing in the brain, which was almost intolerable (second day), 352.
• First proving: After preparing the 2d cent. trituration, put 1 grain on the tongue. There were no marked symptoms through the day, except a constant sensation of frontal headache, which I attributed to the heat of the day, and not to the Opium. At night I slept badly, and much less than usual. The next morning I took a new dose of the 1st trituration. The frontal malaise increased, the head was heavy, and I experienced loss of energy. That night I slept none at all, but there were no disagreeable symptoms. During the whole time that I remained in bed I had no sensation in the head, but on rising in the morning the malaise returned. Towards 11 A.M. I was seized with vertigo, which seemed to me the precursor of the migraine to which I had been subject for more than twenty years. It disappeared and gave place to a headache, which passed off in about three-quarters of an hour. After this I experienced præcordial anxiety, with pain in the stomach, to which I had formerly been subject with the migraine. I was soon obliged to sit down and rest, and I found myself covered with cold sweat, excessively fatigued, succeeded by nausea. All this, however, was nothing new to me, although I had not suffered from so severe an attack for more than fifteen years, and it was entirely out of proportion to the severity of the head symptoms. These distressing sensations did not last long, and I returned to my house and lay down and rested, 354.

EYE. [2320.]

• Eyes red (after eighty minutes), 352.
• Eyes very red (after two hours), 353.
• Eyes glazed, half open, pupils moderately dilated, and immovable (in half an hour), 371.
• Eyes half open and fixed, 359.
• Eye-lids closed (after two hours), 361.
• Heaviness over his eyes (after thirty minutes), 351.
• Conjunctivæ considerably injected (after two hours), 361.
• Conjunctivæ insensible, 370.
• No reflex action was excited by touching the eye itself (after three hours), 361.
• Pupils insensible to light (after seven hours), 363. [2330.]
• Pupils very much contracted and insensible to light (after one hour and a half), 356 ; (after three hours), 361.
• Pupils contracted to a point (after ten hours), 353, 360 , etc.

EAR

• Ears and back of neck livid (after two hours), 361.
• Tinnitus aurium (after sixty-five minutes), 351.

NOSE

• Nose pinched like a cadaver, and could not inspire through it (after three hours and a half), 357.

FACE

• Face pale (after two hours), 353.
• Face pale and ghastly (after two hours), 361.
• Face suffused (after forty minutes), 352.
• Complexion somewhat cyanotic, 370.
• Lividity of countenance, 355. [2340.]
• Face and lips swollen and livid (after one hour and a half), 356.
• Countenance of leaden, deathlike hue, 359.
• Livid lips, 359, 362.
• Lips and tips of ears livid (after three hours), 361.
• Jaws clenched (after two hours), 358.

MOUTH

• Teeth clenched (after two hours), 361.
• Tongue projected, tumefied, and blue (after three hours), 362.
• Tongue swollen and thrust between the lips, and trembling (after ten hours), 360.

THROAT

• Spasm of the throat, 353.
• Inability to swallow, 353.

STOMACH. [2350.]

• No appetite (after three hours), 352.
• Nausea (after forty-five minutes); increased (after seventy-five minutes), 351.
• Slight nausea (after twenty-five minutes), 352.
• In the forenoon of the second day the stomach became much affected with nausea and vomiting, everything she swallowed was soon rejected, 353.
• In five hours had vomited two or three times, in consequence I felt much relieved, though I continued very stupid. The next day a deadly nausea came on me every half hour, and a puking, at first of phlegm, but soon after a copious discharge of bile ensued; every kind of drink was thrown off my stomach soon after it was taken. At 1 o'clock took a draught of a mixture of a solution of salt of tartar, with lime-juice; this, however, was puked up immediately; it increased the nausea and sickness. I vomited at last a dark-greenish liquid, which deposited in the bottom of the vessel a sediment of the same color, 352.
• In the course of the second night her stomach became much swelled with flatus, 353.
• Unpleasant sensation about the region of the stomach (after two hours), 353.

RESPIRATORY ORGANS

• Respiration slow, but not stertorous (after two hours), 358.
• The breathing 9 respirations per minute (after seven hours), 363.
• Respiration stertorous, irregular, and even sometimes interrupted for a considerable time (after three hours), 362. [2360.]
• Breathing was loudly stertorous; respirations only 3 per minute (after two hours); 5 1/2 per minute, jerking and stertorous (after three hours), 361.
• Respirations consisted of a series of two or three feeble gasps, with complete intermissions of from one to three minutes (in half an hour), 371.
• Breathing stertorous, 369.
• Respiration irregular and not full, 359.
• Respirations about 4 a minute, very feeble, 370.
• Respiration slow and difficult (second morning), 352.
• Breathing extremely slow and interrupted, stertorous, and gasping, 353.
• Respiration feeble and irregular (after ten hours), 360.
• Difficulty of breathing (after two hours), 363.
• Respiration difficult, as if almost suffocated (second night), 353.

HEART AND PULSE. [2370.]

• Anxiety at the præcordia (after two hours), 352.
• Sense of heaviness and oppression of heart (after eighty minutes), 352.
• Strong pulsation in the carotid arteries (second day), 352.
• Heart's sounds very weak (after three hours), 361.
• Pulse imperceptible, the heart's action feebly dicrotic, irregular, with not more than 40 contractions in the minute (in half an hour), 372.
• Pulse very quick and irregular, and so weak as to be with difficulty perceptible, 370.
• Pulse 146, irregular in volume and rhythm (after two hours); 140, very feeble, compressible, and irregular (after three hours), 361.
• Pulse 110 and intermittent (after three hours and a half), 357.
• Pulse 100 (after one hour and a half), 356.
• Pulse 80 on taking the drug; 84 (after five to fifteen minutes); 82 (after twenty minutes); 80 (after twenty-five minutes); 72 (after thirty minutes); 80 (after thirty-five minutes); 76 (after forty to sixty minutes); 80 (after sixty-five and seventy minutes), 351. [2380.]
• Pulse 72, before taking; same (after five to twenty minutes); 78 (after twenty-five and thirty minutes); 80 (after thirty-five to forty-five minutes); 84 (after fifty and fifty-five minutes); decline in force, but was full (after fifty minutes); 72 (after sixty minutes); 68 (after sixty-five minutes); 76 (after seventy minutes); 80 (after seventy-five to eighty-five minutes); 84 (after ninety minutes); 80 (after ninety-five minutes); 76 (after one hundred to one hundred and ten minutes); 72 (after one hundred and fifteen and one hundred and twenty minutes); slow and full, without much tension (second morning), 352.
• Pulse small and frequent (second night), 353.
• Pulse feeble and quick (after two hours), 353.
• Pulse scarcely perceptible at the wrist, 353.
• Pulse slow and full (after ten hours), 360.
• Pulse almost imperceptible and also irregular (after three hours), 362.
• Pulseless at wrists and temples (after two hours), 358.

NECK

• Weakness in those muscles which support the head erect (after one hundred minutes), 352.

EXTREMITIES

• Considerable rigidity of the muscles of the arms and legs (after two hours), 361.
• Power of muscular motion diminished; slight pains were felt in the recti and vasti muscles of the thigh; also pain in the arms and legs when I attempted to move them (after eighty minutes), 352.

SUPERIOR EXTREMITIES. [2390.]

• Fingers and nails congested (after two hours), 361.
• Nails greatly congested (after three hours), 362.
• Thumbs of both hands rigidly extended at right angles (after two hours), 361.

GENERALITIES

• Finding no relief I lost sixteen ounces of blood; in a short time after I felt much better. The blood which was drawn had an inflammatory crust formed on the surface; it coagulated very firmly, and the edges by retracting within the bowl and turning up, exhibited the cupped appearance; there was a large proportion of serum, 352.
• He was in normal health, and had fasted eighteen hours before commencing the experiment. He had never smoked tobacco. Twenty-seven pipes, equivalent to 107 grains of the Opium used by the Chinese, were smoked in two hours and three-quarters, at tolerably regular intervals. The third removed the feeling of hunger caused by his long fast, and his pulse rose from 72 to 80. The fourth and fifth caused slight heaviness and desire for sleep, but there was no hesitation in giving correct answers, though he could not guide himself about the room. After the seventh pipe the pulse fell to 70. The twelfth pipe was followed by singing in the ears, and after the thirteenth he laughed heartily, though without any cause that he can remember. Questions asked at this time were answered only after a pause, and not always correctly. He had for some time ceased to be conscious of his actions. After the twenty-fifth pipe, questions asked in a loud tone were not answered. After the last pipe had been smoked, he remarked, "I do not hear well." Forty minutes later there was a slight return of consciousness, and he said, "I am quite bewildered. May I smoke some more? Is the man with the pipe gone already?" Fifteen minutes later (4.55 P.M.) he was able to go home, and then retired to bed. He woke next morning at 3 A.M., and made a hearty meal, after his fast of thirty-three hours. During the next day he felt as if he had bees in a great hollow in his head, as well as a slight headache. The organs of locomotion were first affected, next came sight and hearing, but Herr Maclay is very positive that there were no dreams, hallucinations, or visions of any sort whatever, 373.
• Spasms of the muscles, 357.
• Twitching of the tendons (after ten hours), 360.
• Violent convulsions, the face, neck, and extremities becoming turgid, livid, and cold, 366.
• Frequent fearful spasms; eyes shut, pupils closely contracted, and breathing stertorous. In the interval between the spasm, he was perfectly limp, and had no control over is extremities, and his head drooped forward or fell backward in a heavy, ungovernable way, 364.
• Relaxation in the muscular system (after one hundred minutes), 352. [2400.]
• Muscular system entirely flaccid, 359.
• Very much agitated, frequently rising from the bed, and walking with haste across the floor (after two hours), .

SKIN

• Skin dry (after three hours), 361. [2410.]
• The skin appears more full, as if elevated or swollen, particularly on the face and hands (after two hours), 352.
• About noon of the second day erysipelas of the face began to be developed; and extended from the face to the head quite rapidly, 358.

SLEEP

• Drowsiness (after two hours), 352, 366.
• While an emetic of Sulphate of zinc was operating, there was a great propensity to sleep, but this was of short duration; she did not sleep till some time in the night ensuing, which was seventeen hours after the Opium was taken; she ten slept four hours, after this was much relieved and tranquil for several hours, 353.
• Profound sleep, from which it could not be aroused (after two hours), 358.

FEVER

• Skin cold (after three hours), 362.
• Slight rigors were frequent (second day), 352.
• Face and extremities cold and livid (in half an hour), 371.
• Skin cold and moist, 370.
• Extremities cold, 353, 357 , etc. [2420.]
• Extremities cold and clammy (after one hour and half), 356.
• Surface hot (after two hours), 358.
• Heat on the skin, particularly of the face (after ten minutes), 351.
• Covered with cold clammy sweat (after three hours and a half), 357.
• Slight perspiration on forehead, of a cold, clammy character (after two hours), 361.