Gelsemium

[Not Gelseminum.]

Gelsemium sempervirens, Ait. (Gelsemium lucidem, Poir.; G. nitidum, Michx.; Bignonia sempervirens, Linn; Lisianthus sempervirens. Mill.).

Natural order , Loganiaceæ.

Common name , Yellow Jessamine.

Preparation , Tincture of the bark of the root.

Authorities.

1 , Dr. Henry took tincture, 30 drops first and third days, and then gradually increased the dose daily for one week, Inaug. Dissert., Phila. Hom. Coll., 1852; 2 , Dr. Joshua Stone took tincture, 6 drops first day, 50 drops fourth day, 50 drops eleventh day, Inaug. Dissert., Phila., ibid.; 3 , Dr. F. Bigelow took tincture, 20 drops daily for one week, Inaug. Dissert., Phila., ibid.; 4 , Dr. William E. Payne took fluid extract, 4 drops first day, 5 drops and 6 drops second day, 6 drops third day, 10 drops and 6 drops fourth day, 6 drops fifth and sixth days, 10 drops seventh and eighth days, 3 drops thirty-second day, 5 drops twice and 6 drops thirty-third day, 8 drops twice thirty-fourth day, 6 drops and 8 drops thirty-fifth day, Am. Hom. Review, 2, 80; 5 , Dr. J. S. Douglass, provings on "at least fifty people," mostly with tincture, in doses of 1 to 5 drops, a few took 3d dil., West. Journ. of Hom., 1, 1, and introductory letter in Hale's Monograph; 6 , Dr. J. C. Morgan took tincture (saturated pellets) several times, then 4 drops four times, 5 drops and 6 drops first day, 7 drops second day, 5 drops third day, 5 drops and 7 drops fourth day, 8 drops and 9 drops fifth day, 10 drops and 15 drops sixth day, 21 drops seventh day, Shipman's Am. Journ. of Mat. Med., 1861, No, 4; 7 , Dr. B. Fincke; Mrs. S. took one drop of 1m (centes.), N. A. J., 15, 413; 8 , Dr. Fincke himself tool 3/36m (centes.), ibid.; 9 , Dr. E. M. Amos's proving with 6th dil., 1 drop every two or three hours, then 2 drops per dose, Inaug. Dissert., Hom. Med. Coll. of Missouri, 1860; 10 , Dr. E. M. Hale, symptoms from various observers, Monograph on Gelsemium, 1861; 11 , Dr. F. L. Vincent's proving, Hale's Monograph; 12 , Dr. M. E. Lazarus's proving, Hale's Monograph; 13 , Dr. E. M. Hale, provings on several persons, Monograph (additional); 14 , Zumbrock, proving with tincture, 3 drops first day, 8 drops fourth day, Brit. Journ. of Hom., 21, 419; 15 , Dr. J. J. Douglass, symptoms obtained by repeated provings on self and seven or eight others with tincture, in doses of 1 to 5 drops (Hale's Domestic Medicine), Brit. Journ. of Hom., 21, 414; 16 , Dr. L. A. Fallagant; a surgeon chewed the root in mistake for licorice, Hahn. Monthly, 5, 20; 17 , Tully, effects on a girl, aged 11 years, of eating the inner bark, with the sap, from the stem, Boston Med. and Surg. Journ., 7, 122; 18 , Dr. King; a Mississippi planter took, by mistake, an infusion of the root for bilious fever (Dispensatory) Hale's Monograph, p. 10; 19 , Dr. Langren, a lady took tincture, 10, 11, and 12 drops in three hours, for typhoid pneumonia, Hale's Monograph, p. 11; 20 , A steamboat waiter partook freely of a strong decoction of the root, Nashville Med. Journ., 1866, p. 225; 21 , Dr. Pattee; a condemned prisoner attempted suicide with 1 1/2 oz. fluid extract (Tilden's Journ.), Brit. Jour. of Hom, 21, 407; 22 , Dr. J. T. Main took, by mistake, 1 drachm fluid extract, Boston Med. and Surg. Journ., April 15th, 1869, p. 185; 23 , Dr. R. P. Davis, effects on Mr. B. of a tablespoonful fluid extract (Med. Press and Circular), Am. Journ. of the Med. Sci., 1867, p. 271; 24 , the same, effects on Mr. S. of a like dose, ibid.; 25 , Dr. T. G. Wormley, effects on a healthy woman, several weeks pregnant, of 3 tablespoonfuls fluid extract, Am. Jour. Pharmacy, 1870, p. 14; 26 , Dr. Pinkham, Mrs. F. took "probably much more than 40 drops" of fluid extract, Boston Med. and Surg. Journ., 1871, p. 89; 27 , Dr. W. W. Clap; a man, 27 years old, reduced by remittent fever, was given 22 drops fluid extract within ten hours, Ohio Med. and Surg. Reporter, 5, 302; 28 , Dr. J. T. Boutelle, effects on a man, aged 24 years, of 2 teaspoonfuls fluid extract, in fifteen minutes, for neuralgia, Boston Med. and Surg. Journ., 1874, p. 321; 29 , Dr. J. A. Munk; a child, aged 2 years, tool a teaspoonful of the tincture (Am. Med. Journ.), Am. Hom. Observer, 1875, p. 12; 30 , Dr. Hale, effects of 10 drops of tincture, every four hours, for hysterical convulsions, Brit. Journ. of Hom., 21, 414; 31 , Dr. E. M. Hale, effects experienced by a lady, five months' pregnant, after second dose of 20 drops of 1/10th dilution, and renewed by every repetition of the same, Hahn. Monthly, 6, 125; 32 , effects (Tilden's Journ.), Hale's Monograph; 33 , Dr. Langren. Dr. B. took 30 drops tincture for toothache, Brit. Journ. of Hom., 21, 408; 34 , Holden, experiment with fluid extract, 6 drops twice, then 10 drops at half hourly intervals "The Sphygmograph," p. 150.

MIND

• Emotional.
• Intoxicated feeling, with painless, but slightly diarrhœic stool, 11.
• General vivacity after rising (second morning), 6.
• In one case (it is not said at what stage), great and almost uncontrollable mirthfulness, 5.
• Depression of spirits, with dull, uncertain pains in the head, in the afternoon (fourth day), 6.
• Depression of spirits, 11.
• Melancholy, desponding mood (first day); worse (third day), 1.
• Gloomy and disinclined to exertion of any kind, 3.
• Hypochondriac mood all day, dull, stupid (fourteenth day), 2.
• Anxiety, 11. [10.]
• Irritable, impatient, 5.
• There was at first a cheerful, careless morale, afterwards depression of spirits, 12.
• Intellectual.
• She seemed to know all that was going on; described her symptoms, 19.
• Symptoms lasted several hours, but all the while I retained a clear state of mental activity, 16.
• Dulness of all the mental faculties, 5.
• For several days, rather dull and stupid, with disinclination to conversation, which was remarked by friends, who knew nothing of my taking medicine (fifth day), 2.
• Very dull and stupid, with aversion to study (fourth day), 2.
• Dulness of mind, alleviated on profuse emission of watery urine, 10.*
• Incapacity to think or fix the attention, 5.*
• Mind listless and incapable of reflection, as after ague, with a not severe, dull headache all day, and digging in the right ear all the afternoon (seventh day), 6. [20.]
• The sensorial modification consisted of a mistiness within the brain, not much affecting the lucidity of thought, but somewhat confusing the perceptions, so that I experienced some difficulty in attending to the physical details connected with my practice, 12.
• Inability to concentrate the mind, 11.
• Found it to affect the power of concentration very materially; I could not fix my mind on the contents of a newspaper, although the matter was of an exciting character; I could not pursue one train of thought for any time, the ideas would vanish and leave a vacancy of mind which was quite annoying, 10.
• Confusion of mind, 5.
• Incoherency of thought, 11.
• Stupid, intoxicated feeling, 5.
• Unconsciousness, 29.*
• He threw himself upon the floor and soon became unconscious (after half an hour), 28.
• Totally unconscious, 23, 26.
• Totally unconscious, and could not be aroused (after three hours), 28.

HEAD

• Vertigo. [30.]
• Transient vertiginous sensation, after breakfast (second day), 6.
• *Dizziness of the head and blurred vision returned, and gradually increased, so that all objects appeared very indistinct , for three hours, then gradually abated (one hour after second dose, fifth day), 4.
• Sense of giddiness (one hour and twenty-five minutes after third dose), 34.
• Giddiness is pretty constant; an intoxicated feeling and tendency to stagger; often with dizziness or imperfection of vision, 5.
• Swimming sensation in the head, 32.
• My head began to have a swimming, turning sensation, as if I were going to be seasick, 16.
• Light head, 9.
• Lightheaded and dizzy, much increased by sudden movement of head and walking (one hour after first dose, third day), 4.*
• Lightheaded, and dim vision, continuing for one hour (after first dose, third day), 4.*
• Her head felt very light, 19.* [40.]
• Head felt very light, with vertigo, 32.*
• General Head.
• Head cool to the touch, in the afternoon (eighth day), 7.
• He cannot hold the head erect, 32.
• Dulness of head, at 11 A.M. (fifth day), 6.
• Dulness of the head, with stupor, dry mouth, coated tongue, bitter taste, pulse full and strong, intoxication, vertigo unto falling, 11.
• Heaviness of the head, in the afternoon (tenth day), 7.
• Heaviness of the head, with dulness of mind, 10.
• Heaviness, with sensation of fulness in the head, which increased to a severe headache, relieved on the third day of the proving by copious urination; after which a pleasant languor pervaded the system for some hours, 11.
• Great heaviness of head; sensation as if the brain was heavy, 10.
• *Heaviness of head alleviated on profuse emission of watery urine, 10. [50.]
• A very disagreeable sensation in the head was felt, even before the muscles came under the influence of the drug, but the mind was clear, 22.
• Fulness about the head (sixth day), 4.
• The head feels full and excited or feverish, 9.
• Full feeling of the whole head, with some throbbing and uneasiness of the occiput, 9.
• Full and crowded feeling in head, with pain as if the brain were bruised, and accelerated pulse (90), (eighth day), 4.
• Full, crowded feeling in head, and heat in face (one hour after first dose, third day), 4.
• Full and crowded feeling in the whole head, and a sensation of feverish heat in the face, nevertheless the temperature of the skin did not appear to be augmented, at 2.30 P.M. (fourth day), 4.
• Tightness of the brain, 5.*
• A bandlike pain surrounds the head, with shooting pain in both jaws and parietal bones (third day), 1.
• Dull pains in the head and limbs (third day after six drops), 2. [60.]
• Pain in the head is a very constant symptom, generally dull, stupefying and pressive; more frequently in the forehead and temples, 5.
• Headache beginning after dinner and lasting till evening, 3.
• The headache is very distressing, 3.
• After breakfast dull aching in the head, becoming more severe as the day advanced, in the occiput; headache increased till after dinner, when it was much relieved, but about 4 P.M. returned worse than before, and seemed to increase in severity until in the evening it became excruciating, accompanied with slight nausea; shaking the head seemed to slightly relieve it (sixth day), 2.
• Not severe, dull headache (part of S. 19), 6.
• On waking in the morning, pressure in the whole sinciput, as if too narrow, better by pressing with the hand; compelled to close the eyes (seventh and eighth days), 7.
• Pressive pain in the head, principally the temples, at times in the occiput, at others all over the head, 15.
• Sensation of weight and pressure in the head, 3.*
• *The sensitive bruised sensation of the brain continued for two days (after eighth day), 4.
• *Head symptoms are aggravated by smoking, 5. [70.]
• Headache ceased by sitting, in the evening, as at other times (ninth day), 6.
• During the day tendency to headache on moving, especially on going upstairs (second day), 2.
• The sensitiveness of the brain continued for several hours, and it appeared as if every step and sudden movement of the head would excited pain, but this did not occur (after second dose, third day), 4.
• Head symptoms are felt very soon, sometimes within five minutes, 5.
• Forehead.
• Severe pain in the forehead and vertex, with dimness of vision; roaring in the ears; a sensation of enlargement of the head, and a "wild feeling," a confusion, almost amounting to delirium; the pain in the head, which was of a pressing, heavy nature, would at times disappear, the concomitant symptoms being at the same time ameliorated, and severe, sharp, laborlike pains would set in, in the uterine region, extending to the back and hips ; these pains would in turn leave, and the pain in the head would recur immediately after, 31.
• Some fulness in the anterior part of the head, soon disappearing (after a few minutes), 6.
• A feeling of contraction in the scalp on the centre of the forehead (after first dose, first day), 6.
• Awakened at 2.30 A.M. by most intense aching pain in the left frontal region, extending to the right occipital region, and occasionally over the entire head; it lasted and hour (seventh morning), 2.
• Dull, slight headache all over the front and top of the head, after a sleep in the forenoon; also after sleep in the evening, 9.
• Pressing in the forehead as if too narrow, with pressing upon the eyes, as if too large (sixth night), 7. [80.]
• Severe and pressive pains in the forehead and vertex, 3.
• Sense of weight over the forehead (quarter of an hour after third dose), 34.
• Stitch in the middle of the forehead passing inwards, at 12 M. (tenth day), 7.
• Stitch in the middle of the forehead, passing inwards, in the afternoon (tenth day), 7.
• Now and then a violent stitch in the middle of the forehead, entering as far as half the brain, in the afternoon (seventh day), 7.
• Violent stitches in the middle of the forehead, as far as half of the brain, on turning the eyes, on stooping, and on turning the head, in the evening (eighth day), 7.
• Pains of shooting character in the frontal sinus extending to the eyes and jaws; in the eyes the pains are pricking, extending from the middle of the eyes to the canthi (first day); on the right side the pains seem to roll about in the eye, much more violent (third day), 1.
• Violent stinging pain in the whole forehead, and pressing of the eyes, as if they were too large, with external coldness of the forehead (third day), 7.
• Temples.
• Pressive pains in right temple, with dizziness and blurred vision, such as may follow the use of intoxicating liquors, but without the exhilarating effects (half an hour after second dose); the dizziness and blurred vision were attended by nausea, and continued for three hours (third day), 4.
• Vertex.
• When writing, headache in the top of the head; afterwards in the left occipital region, directly on both sides and in the upper cervical region, and again on the top, and then in the left side, all whilst engaged in writing a few minutes; afterwards a settled, dull, dragging headache, mainly in the occiput, in the mastoid and upper cervical region, extending to the shoulder, relieved while sitting, by reclining the head and shoulders on a high pillow; in the afternoon (seventh day), 6. [90.]
• Drawing on the right side, on the crown towards the occiput (twenty minutes after 5 drops), 14.
• Pains over the whole top of the head, extending to the occiput, with a general dizziness and a disagreeable painful sensation in the whole of the head (first day), must more violent (third day), 1.
• Parietals.
• Pains in the left side of the head, extending from the prominence of the parietal bone to the mastoid process of the temporal, periodically (third day), 1.
• Dull pain on the right side of the head (sixth day), 6.
• Dull ache on the right side of the head, at breakfast (second morning), 6.
• (As usual, after exercise without breakfast, [During the night sat up a long time a patient; slept for five hours on hard chairs, and rode home before breakfast.] headache on the right side, with occasional throbbing from exertion; better after a sleep of a few hours, but renewed by exertion; ceased in the evening when sitting, as at other times (ninth day); the semilateral headache returns (tenth day); continues, doubtless caused by the exciting news of the day (twelfth day)), 6.
• Dull pain in the region of the occiput (fourteenth day), 2.
• Dull, heavy pain in the region of the occiput (first night), 2.
• On rising, dull pain in the occiput and slight tendency to throbbing, on the right side of the head; previously at breakfast, transient slight cutting pressure on the left side (third day), 6.
• At 11 A.M. severe aching pain in the occipital region for a few minutes (fourth day), 2. [100.]
• Dull aching in the occipital region, occasionally extending into the os frontis (third night), 2.*
• During the day dull aching in the occiput, increased by movement, especially on stooping; much worse towards evening (second day, after 6 drops), 2.

EYE

• Objective.
• Dull eyes, in the forenoon (eleventh day), 7.
• Eyes transiently bloodshot (third day), 6.
• Strabismus, and constant inclination to squint (one case), 10.
• Eyes fixed, and inability to raise the eyelids (after five hours), 25.
• Eyes much inflamed and weak, with great flow of tears at intervals, 3.
• Subjective.
• Dryness of the eyes, 5.
• Heaviness of the eyes , as after night-watching, 11.*
• Pains deep in the left eye, extending from above downwards (first day); more violent (third day), 1. [110.]
• Burning of the eyes, as if they were too dry, in the forenoon (eleventh day), 7.
• Burning in the eyes, with weakness of sight and heaviness in the forehead (fifth day), 7.
• The eyes felt quite sore; it is as if some foreign body were irritating the conjunctive, in the evening (third day), 2.
• The eyes quite sore at night; not much pain, but merely soreness, with sensitiveness to light and lachrymation (third night), 2.
• Brow and Orbit.
• Drawing over the eyes (four minutes after three drops), 14.
• Drawing over the right eye (eight minutes after five drops), 17.
• Pain in the orbits, sometimes excessive, 5.
• Dull full feeling (attended with some aching) in the whole of the orbits, 1.
• Bruised pain above and back of the orbits, 5.
• Lids.
• *Drooping of the eyelids, 29. [120.]
• Eyelids partially closed and motionless, 26.*
• Eyelids half closed, with apparent inability to move them, 23.*
• Eyes close in spite of him, on looking steadily at anything, 5.*
• Difficulty in opening the eyes, or in keeping them open, 5.*
• Heaviness and congestion of the lids, 5.
• Great heaviness of the lids, 5.*
• Burning sensation around the inner canthus of the right eye, 9.
• Eyelids are as it were puffed and swollen, and have also the appearance of being so, 15.
• A stitch traversing the right eyelids vertically (fifteen minutes after first dose, first day), 6.
• Lachrymal Apparatus.
• Eyes suffused (after second dose, fifth day), 4.
• Ball. [130.]
• No spasmodic movements except the eyeballs, which kept up a continual twitching motion while the effects of the medicine lasted, 29.
• Sharp stitches through the left eyeball, from within outward, 9.
• Pupil.
• Dilated pupils, 21, 34.*
• Pupils dilated, but corresponding to the different degrees of light; afterwards widely dilated, 23.
• Pupils dilated, not responding to the light, and could be touched without producing any contraction of the lids (after three hours), 28.
• Pupils expanded and insensible to light (after five hours), 25.
• Dilatation of the pupils, amaurosis, blindness, dimness of sight, 11.
• Pupils moderately dilated, 26.
• Vision.
• Slight affection of sight, during the forenoon (eighth day), 6.
• Till 4 P.M. the disturbance of sight was great (seventh day), 6. [140.]
• Dimness of vision (part of Ss. 74 and 257), 25.*
• Dimness of sight and vertigo, 10.
• Dimness of sight alleviated on profuse emission of watery urine, 10.
• Distant objects seemed indistinct as I rode or walked, and one evening I could read but with difficulty (these symptoms are characteristic, as the sight is perfectly good, and I have never had anything the matter with my eyes), 12.
• Misty or glimmering appearance before the eyes, 5.
• *Smoky appearance before the eyes, with pain above them (third day), 1.
• She complained of being partially blind, while eating a hearty dinner (after half an hour); this symptom rapidly increased, and in a short time she could scarcely see at all, 17.
• Nearly blind; control over the upper eyelid was almost entirely lost, 23.*
• Blind, 24.
• Total blindness very soon after the dose, with violent dizziness (third day), 1.* [150.]
• Became perfectly blind, eyes set, etc., 27.
• She could not see any one in the room, although persons stood close by the bed; the eyes were wide open; pupils dilated, 19.
• *He said, "I cannot see you;" but his eyes were wide open, with dilated pupils (after ten minutes), 34.
• Confusion of sight (one hour after first dose, third day), 4.
• Slight more or less confused all day (fifth day), 6.
• At 4 P.M. took a dessertspoonful of red wine; directly after, for the first time to-day, a return of the confusion of sight, lasting an hour only, but so extreme that some one must suspect inebriation (fourth day), 6.
• After the stool in the morning, a marked renewal of the confusion of sight, with heavy looking eyes; found this symptom much less when holding a finger vertically beyond the nose, also when either eye is closed (third day), 6.
• The confusion of sight much increased in the evening (sixth day), 6.
• Confusion of sight diminished, in the evening (third day), 6.
• Confused vision, especially of distant objects (following vertiginous sensations after breakfast), when turning the eyes the sight is tardy in following the movement, things for several seconds seem to be blurred, the eye remains unfixed in its, new direction, yet no sensation of gauze or film, [This symptoms attended a tardy convalescence from a fever (not treated by Gelsemium, except the first day), last year, continuing a week; relieved by Nux vom, 3 , in part, and finally cured by Acon, 3 ] it is accompanied with a disposition to partially close the eyes, as if to steady the eyeballs by the pressure of the orbicularis palpebrarum muscles; the visual confusion might be compared to that produced by alcohol, and gradually wore off by night (second day), 6. [160.]
• Objects appeared double ; by degrees she grew completely blind, 26.*
• Things seem double on raising the head from a stooping position, or on looking sideways, but not when looking directly at them (one case), 5.
• Diplopia, which I could control by an effort of will, 12.*
• Diplopia when inclining the head towards either side, but vision single when holding the head erect (in one case), 5.*

EAR

• Rush of blood into the ears, 10.
• The pains which ascend from the back to the occiput often affect the ears, 10.*
• Heavy feeling in the ears (a quarter of an hour after third dose), 34.
• Digging in the right ear (part of S. 19), 6.
• Near noon, while sitting, a stitch in the external auditory meatus (eighth day), 6.
• Hearing.
• Sudden and temporary loss of hearing, 10. [170.]
• Humming in the ears (after eighteen minutes), 14.

NOSE

• Objective.
• Sneezing and dull headache, at 9.30 P.M. (sixth day), 6.
• Sneezing, followed by tingling and a sense of fulness of the nose, at 11.30 P.M. (first day), 6.
• Watery discharge from the nose (in a few cases), 5.
• Mucus accumulates in the nose and upper part of the trachea; the mucus slips into the trachea while talking, which keeps up a hacking cough, 9.
• Bloody mucus in the nose (eleventh day), 6.
• While sewing, lively action, as of a worm or a fish, in the region of the nose, at 6 P.M. (twelfth day), 7.
• Pain extending from the bridge of the nose to the eye (third day), 1.
• Tingling in the nares (eleventh day), 6.

FACE

• Objective.
• Looked strange, staggered, and feel (after half an hour), 29. [180.]
• Heavy besotted appearance of the face, 13.*
• Countenance miserable, sunk, grayish-yellow, with dull dusky eyes (second day), 7.
• Face flushed and hot to touch (after second dose, fifth day), 4.*
• Yellow color of the face, 5.
• Complexion yellow, also the eyes, 1.
• Countenance of livid paleness, 26.
• Face somewhat congested, 23.
• The muscles of the face seem to contract, especially the orbicularis oris, somewhat impeding breathing, 11.
• Subjective.
• Numbness of the face, 11.
• Cheeks.
• Whenever she was roused from her sleepiness she felt burning in the zygomatic region and eyes (afternoon), (seventh day), 7. [190.]
• Burning at the left zygoma and in both eyes, more in the left one (fifth day), with red swelling of the zygoma, a little before 2 P.M. (sixth day), 7.
• Burning in the left zygoma, with swelling; and in both eyes, more in the left; later, also in the right zygoma at 1 P.M. (seventh day), 7.
• Burning in the left zygoma, then in the right, drawing down to a gland at the anterior right side of the neck, where it swells, and pains as if an ulcer were forming, in the afternoon (eighth day), 7 . [At this very spot she had twenty-two years ago a glandular abscess, which opened internally.]
• Lips.
• Pale lips, in the forenoon (eleventh day), 7.
• Lips dry and heated, at 11.30 P.M. (seventh day), 6.
• Chin.
• Lower jaw drooping, 23 ; (after three hours), 28.
• Lower jaw drooping, leaving the mouth wide open, 26.
• His lower jaw began wagging sideways; he had no control over it, 27.
• Sensation of stiffness in the muscles of the jaw, 13.

MOUTH

• Teeth.
• Pain in the last back tooth on the right side up towards the temple (first day), 1. [200.]
• Stinging and burning in the left lower hollow back tooth (otherwise her teeth are good, of the ivory variety) through the lower jaw, as far as the left ear and left zygoma, at 6 P.M.; relieved by Chamom. 2/30 in watery solution (twelfth day), 7.
• Tongue.
• Thickly coated tongue, 11.*
• Tongue coated yellow (first day), 1.
• Light whitish coating on the tongue (seventh day), 6.
• Yellowish white fur on tongue (third day), 2.*
• Yellowish-white coating of the tongue, with fetid breath, 11.
• Tongue red, inflamed in the middle, 30.
• *Numbness of the tongue, 11.
• I so lost the use of my tongue that I was unable to utter an intelligible expression, and my tongue felt like some foreign body clogging my mouth, 16.
• His tongue, to use his own expression, was so thick he could hardly speak, 23.* [210.]
• His tongue felt very thick; he could not articulate, 27.*
• Burning upon the tongue immediately, which after a few minutes went over the whole mouth and throat, feeling hot like an oven, and thence through the œsophagus into the stomach and abdomen, when the same burning pain passed around in all the intestines; simultaneously with the descent of the burning pain into the œsophagus, burning in the chest came on, following soon by a stitch in the anterior left lower side of the chest, going through the chest into the left shoulder-blade, and accompanied by weakness and a fluttering and beating of the heart, irregular as to quantity and quality; these symptoms lasted about three hours (first day), 7.
• Peculiar sense of constriction at base of tongue (twenty minutes after third dose), 34.
• Mouth.
• Clammy, feverish feeling and taste, 5.
• Astringent sensation in the mouth, 11.
• Dryness of the mouth, 11.
• Slight dryness in the mouth and throat, with disposition to swallow frequently; the dryness is like that produced by eating salt bacon , but no bacon has been eaten to-day, 9.
• Saliva.
• Several times during the day he found the saliva colored yellowish, as if by blood (seventh day), 6.
• During the fits, sanguineous brown mucus ran out of her mouth, 39.
• Taste.
• Mawkish taste in the mouth, 5, 11. [220.]
• All the latter part of the day, bad, foul, spoiled taste and breath, with a frequent need to rinse the mouth or spit (seventh day), 6.
• Bitter taste, 11.
• Slimy, disagreeable, bitter taste in the mouth, 15.
• Speech somewhat affected, 22.
• After the return of consciousness, intelligible speech was at first only possible when the jaws were supported. The tongue was stiff and the voice thick and guttural, 26.
• Ineffectual efforts to articulate, 10.
• Inability to speak or move, 21.

THROAT

• Hawking up of bloody matter, 30.
• The burning at times seemed intolerable, and swallowing was painful, 30.
• Sore feeling during deglutition, about the root of the tongue and larynx, with accumulation of mucus in the upper part of the trachea, causing frequent clearing of the throat, 9. [230.]
• Dryness and burning in the throat, 30.
• Fauces and Œsophagus.
• Painful dryness of the fauces, 11.
• While sitting at studies a rising of tasteless semi-solid matters in the œsophagus, with flatus and a sense of something lodged therein, slightly painful, at 12.30 (one hour after 9 drops, fifth night), 6.
• Violent burning in the gullet from the mouth quite down to the stomach, 30.
• Spasmodic sensations and cramplike pains in the gullet, 30.*
• Tried to swallow but could not, 27.*
• *Owing to paralysis of the muscles of the throat the patient could not swallow when the physician was called, 20.
• External Throat.
• Pains in the neck, which confine themselves to the upper part of the sterno-cleido-mastoideus directly back of the parotid glands (first day), 1.*

STOMACH

• Appetite.
• Great hunger (one case), 5.
• After a moderate meal, experienced a sudden satiety (ninth day), 6. [240.]
• Want of appetite in the afternoon (seventh day), 7.
• Alternate increase and loss of appetite, 11.
• Thirst.
• Thirst during the sweat, 5.
• Eructations and Hiccough.
• Eructations, 5.
• Eructations of wind and bland fluid, at 11.30 P.M. (first day), 6.
• Sour eructations, 11.
• Hiccough, 5.
• Heartburn.
• At noon, slight heartburn and pain at the cardia, whilst riding (first day), 6.
• Nausea and Vomiting.
• Nausea, 5.
• Nausea and vomiting, 21. [250.]
• Slight nausea, 11.
• Considerable nausea (after three-quarters of an hour), 17.
• More or less nausea, with headache, 5.
• Stomach.
• Feeling of emptiness and weakness of the stomach and bowels, 5.
• A sensation as of something wanting in the epigastric region (third day), 2.
• Rumbling and dull pains in the epigastric relieved by expulsion of flatus, 11.
• Pain in the stomach, extending from the pyloric end of it to the axilla and under the scapula, and down the right arm to the external side of the forearm, it terminates about a hand's breath from the elbow; this passed off after taking biscuit and coffee, 9.
• Pain in the stomach, nausea, and dimness of vision (after two hours); these symptoms were soon succeeded by ineffectual efforts to vomit, great restlessness, and free perspiration over the body, 25.
• Gastralgia and colic, coincident with the intoxicated feeling, in the afternoon (fourth day), 6.
• Cardialgia, when driving, at 11 A.M. (fifth day), 6. [260.]
• Continued cardialgia, and eructations, when sitting in the evening (sixth day), 6.
• Burning in the stomach and abdomen (part of S. 211), 7.
• Seized with violent cramplike pains in the epigastrium, causing an involuntary cry, lasting but a moment, and then subsiding, leaving a constricted sensation for one hour (three hours and half after first dose); followed by a sensation of heat and burning in the stomach (third day), 4.
• Gastric oppression; had to loosen the waistband, after which colicky sensation to the left of the navel, as if a stool would shortly follow, at breakfast (second morning), 6.

ABDOMEN

• Hypochondria.
• Slight pains in the left hypochondriac region (third day), 2.
• Frequent sharp drawing pain through the left hypochondriac region, 5.
• Pulsative pains in left hypochondrium, continuing for one hour, at 3.30 P.M. (fourth day), 4.
• Umbilical.
• Rumbling in the region of the umbilicus, 5.
• Dull aching in the umbilical region, which lasted till I go up (seventh morning), 2.
• Sharp stitches around the umbilicus, 9. [270.]
• Colicky pains below the navel, extending down to the testes, caused by flatus, and relieved by its expulsion, in the evening (fourth day), 6.
• Two little painful spots on the right side of the umbilicus, extending down into the bowels; the pain is increased by pressure, 9.
• General Abdomen.
• Rumbling and rattling in the abdomen, with emission of flatus above and below (first day), 1.
• Evacuation of flatus both ways, frequently (first day), 6.
• Palpitation of the abdominal muscles about three minutes (tenth day), 2.
• Weak nauseated feeling in the bowels, 9.
• Heaviness, and feeling of weight in the bowels, 3.
• Pain in the bowels towards morning (third night), 2.
• Slight pain in the transverse colon, with yellow color of the skin of the face (one case), 5.
• Burning in the abdomen, the pain going round in the intestines, towards 12 o'clock (second day), 7. [280.]
• Slight griping pains through the abdomen, mostly in the umbilical region, after supper, 9.
• Dull pains in the abdomen, 11.
• Dull pain in the bowels, which became very severe towards morning (first night), 2.
• Sharp pains in the bowels, with stools of a light creamy color and pappy consistence, 11.
• Sleep disturbed by lancinating pain in the abdomen, relieved by copious discharge of flatus, 11.
• Colic, in the evening (ninth day), 6.
• Slight colicky feeling as if the bowels would be moved, at 11.30 P.M. (first day), 6.
• Tenderness of the abdominal parietes, 10.
• Gnawing pain in the region of the transverse colon, all the afternoon, 5.
• Movement of flatus in the lower bowels, at 11.30 P.M. (first day), 6.
• Hypogastrium and Iliac Regions. [290.]
• After experiencing chills, headache, feverish and prolonged sweating seventeen hours after taking the drug, awakened by severe moving pains in the lower abdomen, soon followed by a very large but natural stool, without relief of the pains, and soon after a deeply bilious discharge, with instant relief of the pain; nine hours afterwards another bilious evacuation without pain (one case), 5.
• One of the right inguinal glands became swollen and tender to touch, 9.
• Pain in the left iliac region (first day), 1.
• Slight pain in the left iliac region (two cases), 5.

RECTUM AND ANUS

• The piles returned with raw, smarting pain, 9.
• Exciting news caused, apparently, urging to stool; stool papescent, of dark-yellow color (sixth day), 6.

STOOL

• Diarrhœa.
• Bowels loose, but great difficulty in discharging anything; there seems to be great strength in the sphincter muscles (first day), 1.
• After breakfast a good stool; after supper a second stool, consistent (third day), 6.
• Bilious stools (twelfth day), 6.
• At 9.30 A.M., a soft bilious stool, preceded by threatenings of diarrhœa; the latter renewed at noon by exciting news, and afterward when walking (seventh and eighth days), 6. [300.]
• Deep yellow, soft stool, after breakfast (tenth day), 6.
• A stool, at first consistent, then papescent, bilious, homogeneous, a few minutes past 10 A.M., preceded all the morning by flatulence (fourth day), 6.
• Tea-colored, semi-solid stool (eleventh day), 6.
• Stool of deep yellow color (papescent), after breakfast (fifth day), 6.
• After breakfast, a tea-colored stool, more consistent (ninth day), 6.
• Constipation.
• At 11 A.M., having put off the usual defecation, had a slow stool, leaving a sensation of more remaining to be passed, and abdominal repletion (second day), 6.
• Insufficient stool, at 10 A.M. (first day), 6.
• Attempted to pass a stool, but much wind only passed, in the evening (ninth day), 6.
• Relief of constipation (several cases), 5.

URINARY ORGANS

• Urethra.
• Painless redness about the orifice of the urethra (eighth day), 6. [310.]
• Agreeable sensation during micturition throughout the course of the urethra, 11.
• A feeling as if something remained behind when urinating; the stream stops and commences again, 9.*
• Micturition.
• Frequent micturition; wants to urinate every half hour.
• *Frequent emission of clear limpid urine, with seeming relief to the dulness and heaviness of the head, 11.
• Urine increased in quantity, clear and watery, 5.*
• Urine much increased in quantity (first night), 2.
• In nearly every instance the profuse emission of watery urine was accompanied by transient chilliness, tremulousness, and an evident alleviation of the sensations of heaviness of the head, dulness of mind, and dimness of sight (several, who made partial provings for me, noticed the same symptoms, with the alleviations), 10.
• Urine.
• Urine at times clear and limpid; at times milky and turbid, 11.

SEXUAL ORGANS

• Male.
• In connection with the general prostration, accompanied by diuresis, there was always much flaccidity, with coldness of the genital organs, 10.
• Irritation of small spots on the mucous surface of the prepuce, with surrounding congestion (third night), 6. [320.]
• In the afternoon and evening some irritability of the right testis, afterwards dragging pain in the same, extending into both groins and the hypogastrium, followed by discharge of flatus and relief of the pain (first day), 6.
• *Emission of semen without erection (twelfth night), 2.
• Female.
• Severe, sharp labor-like pains in the uterine region, extending to the back and hips (part of S. 74), 31.
• A discharge of blood per vaginam; came on about 4 P.M., after the symptoms had subsided, lasting one hour (second day); after 6 P.M. (third day), 7.

RESPIRATORY ORGANS

• Larynx and Trachea.
• Paralysis of the glottis, with difficulty of swallowing, 10.
• When eating, the food drops into the trachea, causing strangling, 9.
• Burning in the larynx and down into the chest under the sternum, 10.
• Voice.
• Voice seems weak, 5.*
• Voice thick, as if the tongue were too large, 10.
• Paroxysms of hoarseness, with dryness of the throat, 5.
• Cough and Expectoration. [330.]
• Cough from tickling, and dry roughness of the fauces, 10.
• Cough, hacking, with a feeling as if a drop of liquid had entered the windpipe, with frequent clearing of the throat, 9.
• Inability to expectorate, 27.
• Breathing slow, sighing, and at time sobbing, 29.
• Breathing slow and superficial, with now and then a deep inhalation, 9.
• Slow breathing, with rapid pulse (primary), 10.
• Breathing unnaturally slow, 10.
• Peculiar slowness of respiration, seven to the minutes (fifty-five minutes after third dose), 34.
• Respirations somewhat diminished in number; afterwards breathing spasmodic, 23.
• Respiration almost imperceptible, 10. [340.]
• Irregular breathing and slow respiration (part of S. 510), 25.
• Sighing respiration, 10.
• Respirations of a sighing, catching character, 10.
• Respiration gasping, three or four per minute (after three hours), 28.
• Breathing stertorous, and very imperfect, 26.
• Fetid breath, 11.
• Offensive breath, slow breathing, and slow pulse (primary), followed by rapid breathing and quick, weak pulse (secondary), 10.
• Heavy breathing (in the morning), (eighth day); (in the afternoon), (seventh day), 7.
• Heavy and labored respirations, 10.
• Sudden sensation of suffocation, as in hysteria, 10. [350.]
• He complained of choking (after half and hour), and soon rose struggling for breath, pushing his fingers into his throat, as if trying to tear it open, 28.

CHEST

• Great weakness in the chest on speaking (second day), 8.
• Heaviness upon the chest in the afternoon (seventh day), 7.
• Burning in the chest (part of S. 211), 7.
• Burning in the chest, with fulness, sighing, and anxiousness, going into the pit of the stomach, and radiating all over the whole abdomen like a tree the stem of which is in the pit of the stomach, and the branches of which burn asunder towards the abdomen; this burning is different in kind from the one observed on the first day; it is to her feel, not in the intestines, but in the parts covering them; at 12 M. (fifth day), 7.
• Constrictive pain round the lower part of the chest, 5.
• Short paroxysmal pain in the superior part of the right lung on taking a long breath; it sticks from above downward; this pain is one of the prominent symptoms (first day), 1.
• Stitches in the chest, 5.
• A sensation of soreness in the chest when coughing, 10.
• Pain behind the fifth rib to the left of the sternum, from flatus, relieved by eructation (third night), 6. [360.]
• Burning under the lower part of the sternum, with heaviness of the chest, drawing towards the place of the stitch in the left lower anterior side of the chest, which also now is repeated, and pain like ulceration, tender to touch; as soon as the burning went over to the left side, the chest felt easier; in the afternoon (eighth day), 7.
• Burning like fire at the very spot where she lately had the stitch in the left lower anterior side of the chest, as large as a dollar, and painful to the touch, like an ulcer, and from the pressure of even a loose dress, with fulness, at 8 A.M., lasting five minutes, and repeated four times (fifth day), 7.
• Cramp in the right side of the region of the last short ribs, 9.
• A dull, full aching, extending from the ensiform cartilage along under the free ends of the right short ribs to the lumbar region, as if the liver were congested; the worst pain is about a hand's breadth from the lower end of the sternum, 9.
• At 2 P.M., when lying down, pain under the floating ribs of the left side, suddenly, as if thrust with a sharp instrument; in an instant the pain disappeared, but appeared as suddenly in the left temple, causing an involuntary contraction of the brow (fourth day), 4.
• Stitch in the anterior lower left side of the chest in the afternoon (tenth day), 7.
• Stinging in the left lower anterior side of the chest through to the left shoulder-blade, and irregular beating of the heart on sitting quiet, and worse than yesterday (third day), 7.
• Stinging though the left lower side of the chest into the left shoulder-blade, also more severe than yesterday; at the same time irregular beating of the heart, with dyspnœa, worse than yesterday (second day), 7.
• Mammæ.
• Shuddering pain in the right breast, 5.
• Periodical pains in the pectoral muscles (third day), 1.

HEART AND PULSE

• Præcordium. [370.]
• Stitching sensation in the region of the heart, 5.
• Shocks at the heart, with heavy breathing, at 12 M. (tenth day), 7.
• At every exertion, shocks at the heart, throbbing of the pulse through the whole body, tremulousness, weakness, and sweat, in the forenoon (eleventh day), 7.
• Heart's Action.
• Irregular beating of the heart form 12 M. till 5 P.M . (eighth day), 7.*
• Beating of the heart irregular as to quantity and quality (part of S. 211, 367), 7.
• Irregular beating of the heart , less violent than before (during the shaking, trembling of the body), in the afternoon (fifth day), 7.
• Palpitation of the heart in the afternoon (eighth day), 7.*
• Pulse.
• Pulse continued accelerated (after second dose, third day), 4.
• Pulse rapid and feeble (after three hours), 28.
• Pulse very rapid, small, and weak, 29. [380.]
• All the afternoon pulse very small and quick, 5.
• Directly after the reaction has followed the chill, the pulse rises a as far above the normal state as it has been previously below it, 15.
• On the 12th of November, at 9 P.M., six drops were taken, at 9.30 six drops more, and at 10 o'clock ten drops; the results, which were as follows, more also indicated on the chart. Not being perfectly well, there existed either a recoil or dicrotic wave in the preliminary tracing, which in thirty minutes seemed rather to become more prominent, and, but for the records that follow, might be at once set down as a true dicrotous wave, as at this time there will also be seen diminution of compressibility, as shown by diminished amplitude under the same pressure; the prominence of the waves, whatever its explanation, must be ascribed to a morbid condition, viz., that produced by the influence of the poison administered; the pulse at this interval has reached a minimum as to frequency, and in ten minutes more shows slight impairment of rhythm; the new dose of ten drops exhibits its first influence in the tracings in thirty minutes, by increased arterial tension and nervous stimulation, followed however in five minutes by diminution of both, and great decrease in frequency; from this time on to the end of an hour the tension in the arterial system slowly increased, although the frequency remained nearly the same, and after one hour and a half the appearance of some obstruction, as shown in the flattening of the conjoined apices of the first and second events, was manifest, and irregularity of impulse and of rhythm exhibited the effects of the poison upon the heart. The simple deduction from this investigation, apart from what is already known of the remedy, lies in this, that while reducing the frequency of the pulse, it does so with an increase of arterial tension , and after awhile impairment of the heart's action, indicating a toxic influence upon the nervous system, 34.
• Some depression of the pulse, 27.
• Pulse very uniformly depressed, and rendered less frequent by 10 to 20 beats per minutes, within the last five or ten minutes, if the subject remains quiet, but subject to great variations from exercise; in one case the pulse increased from 60 to 70 in the first five minutes, but in the next trial it was diminished 10 beats in five minutes, 5.
• Within a few minutes, sometimes within two or three, a marked depression of the pulse, which becomes 10, 15, or 20 beats less in a minute if quiet; greatly disturbed by movement, 10.
• Within a few minutes (sometimes two or three) a marked depression of the pulse is observed, with a diminution of 10, 15, or 20 beats per minute, but this only in a state of rest; when moving it is variable, 15.
• Pulse slow and full, or slow and soft, 13.
• Pulse slow and weak, 9.
• Pulse 100, regular, but weak, 26. [390.]
• Pulse, when sitting, 76 at 11 A.M. (third day), 6.
• Pulse 72 in the evening (sixth day), 6.
• Pulse 65 in the forenoon (eleventh day), 7.
• After writing awhile, pulse 64 to 68 at 11.30 P.M. (seventh day), 6.
• On lying down, pulse 54 to 60; when sitting up, 64 to 68, in the afternoon; when sitting, 72, and always full and strong, as usual, in the evening (third day), 6.
• Pulse 53, small and weak, at 12.30 P.M. (fifth day), 7.
• Irregular pulse in the afternoon (tenth day), 7.
• Pulse feeble, irregular, and sometimes intermittent (after five hours), 25.
• Pulse 58, weak, wiry, unequal; when the first stroke is stronger than the preceding one, the second one is scarcely perceptible, or vanishing altogether; irregular double action of the heart, as described above, with intermittent pulse, shaking of the heart, so that she feels it as far as the neck, at 12 M. (ninth day), 7.
• Pulse 60, hardish, intermittent, after about 10 beats; during the intermission of the pulse, two quicker double strokes of the heart are observed by auscultation, changing in rhythm, but not in time, at 12 M. (eighth day), 7. [400.]
• Fluttering pulse, 13.
• Pulse full, 120, 13.
• Pulse regular and full, 19.
• Weak pulse, 21.
• Pulse small and feeble; afterwards, almost imperceptible, 23.
• Pulse soon becomes very feeble in many cases; sometimes scarcely perceptible, with chilliness, cold feet, heat and pain of head, etc., 5.
• Pulse frequently soft, weak, so feeble as to be sometimes imperceptible, 13.

NECK AND BACK

• Neck.
• Rheumatic pain in the left side of the neck, on lying down, soon passing off (one hour after 15 drops, sixth day), 6.
• Aching and soreness of the muscles of the neck and shoulders continued for four days (after eight days), 4.
• Aching on the left anterior part of the trapezius muscle (in the neck), when leaving a warm room (eighth day), 6. [410.]
• Contractive sensation in the right side of the neck at 5 P.M. (seventh day), 6.
• Back.
• Feeling of weakness in the back and limbs, with sleepiness, 15.
• Pain in the back, as in the cold stage of ague (many cases), 5.
• Dorsal.
• After breakfast, sharp shooting pain from the right shoulder to the dorsal vertebræ (seventh day), 2.
• Soreness of the trapezius muscles on moving (eighth day), 4.
• Lumbar.
• Dull pain in the lower lumbar and sacral region (tenth day), 2.
• Aching in the loins (eighth day), 4.
• Sacral.
• Dull pain in the sacral and lower lumbar region (first night), 2.
• At supper-time, going into a warm room, aching in sacro-iliac and lumbar regions and lower part of left thigh, with languor and thirst, as when a fever is commencing; felt the pains more when eating (ninth day), 6.
• Dull aching pain in the sacral and lumbar regions, which came on about 3 A.M. (third day), 2.

EXTREMITIES IN GENERAL. [420.]

• Trembling in all the limbs ; in the afternoon (eighth day), 7.*
• Trembling in the limbs, with chill, at 1.30 P.M., followed by violent stinging in left mamma, from inside outwards, along the lactiferous ducts, especially in one spot, in the sternal half of the breast (second day), 7 . [When seventeen years of age she had a sore breast, with ulceration, pain on touch; this was the result of a cancerous tumor from a contusion by a cows horn, and drawn out by an application of a black paste of a veterinary surgeon, Dr. Lang; the breast got well, though it became smaller in size than the right; she afterwards nursed her six children and never had any trouble in it; yet there was not so much milk in it and the children did not like it as well as the right; twice during pregnancy she had stinging in the place mentioned, after taking cold, but without further consequence; also from homeopathic remedies she had never observed any pain there; still in feeling with the finger, she can detect a kind of cavity, which is always somewhat sensitive on pressure, probably from rough handling at the first confinement.]
• I gradually lost the control of my limbs, so that I could not direct their movements with precision, 16.
• Weakness of the limbs towards 12 o'clock (second day), 7.
• Heaviness in all her limbs (after four hours and a half), 7.
• A sensation as if a galvanic current were passing down the forearms and hands; the same also in the feet; while sitting (after one hour, fifth day), 4.
• Awakened by pains in the limbs, at 4 A.M. (seventh day), 2.
• During the night pains in the extremities, worse after midnight, abating during the day (ninth night), 2.
• During the night pains of the limbs as usual, especially forearms and calves; also in the elbow and knee-joints, all similar to the previous, only less severe (eleventh day), 2.
• Pains in left elbow, wrist, and knee, and in both ankles (after second dose, third day), 4. [430.]
• Slight pain in the muscles of the extremities (thirteenth night), 2.
• Awoke about 3 or 4 A.M., with severe pains in both the upper extremities, which seem to be seated deep in the muscles; also severe in the left arm and forearm, and in both the calves (fifth morning), 2.
• Deepseated pains in the muscles of the extremities, relieved by movement (seventh morning), 2.
• Rheumatic pains in the extremities (sixth day), 2.
• Rheumatic pains in the bones and joints of the extremities and back (third night), 2.
• Burning, running through all the limbs, with burning in the first joint of the left index finger, as if the blood would come out, in the afternoon (eight day), 7 . [This joint is stiff and anchylosed from a wound, incised, when she was three years old.]
• Dull pain in the humeral region, and also in the lower extremities, which seems to be in the bones or deep in the muscles, at 10 A.M. (second day), 2.
• Dull aching pain (deepseated), both in the upper and lower extremities, and joints generally (third day), 2.
• Pulsative pains in the left hand and joints of the fingers, and at the same time in the right foot, more severe in the ball of the great toe, continuing for two hours; when lying down (after five hours, fifth day), 4.

SUPERIOR EXTREMITIES

• Arm.
• Spasmodic pains extending from the inner condyle of the right arm to axilla (third day), 1. [440.]
• Dull pains in the muscles of the right arm and shoulder, and some of the time in the left arm and lower extremities (twelfth day), 2.
• Elbow.
• After writing for a few minutes, crampy pain in the bend of the right elbow while waking (ninth day), 6.
• At 7.30 P.M., violent aching in the left elbow (thirteenth day), 2.
• At 3 P.M., in a draughty church, felt a drawing and aching about the left elbow, for a quarter of an hour (fourth day), 6.
• Sensation as if a galvanic current were passing through the forearms, at 6 P.M., continuing for half an hour (eighth day), 4.
• Pain in the flexor muscles of the right forearm (first day), 1.
• At 9 P.M., pain in the right wrist of a full kind, with great weakness of the same (fourteenth day); the pain less severe, but still it is still quite weak (fifteenth day), 2.
• At 6 P.M., sharp pain in the right wrist (thirteenth day), 2.
• The flexor muscles of the hands and arms were paralyzed, while the extensors were nearly so, 22.
• Sensation in hands and arms blunted, but not in proportion to the loss of motion, 22. [450.]
• Drawing stitches in the dorsum of the right hand, running down into the middle and ring fingers, 9.
• Pain in the little and fourth fingers (first day), 1.
• Early in the morning sharp shooting pains in the joint of the last phalanx of the right thumb (twelfth day), 2.

INFERIOR EXTREMITIES

• Objective.
• Staggering like one intoxicated, 32.
• Gait staggering and very infirm (one hour after first dose, third day), 4.
• He tried to walk, but staggered as if drunk, 29.*
• He staggered, reeling from one room to another, as in intoxication (after half an hour), 28.
• *Fatigue of the lower limbs, after slight exercise, 11.
• During and after a walk, it seems as if the limbs could not be moved another step, 3.
• Loss of voluntary motion of the lower extremities, 11.
• Subjective. [460.]
• Pain in the lower limbs (very common), 5.
• Paroxysmal pain in the left lower extremities (first day), 1.
• Dull pain in the lower extremities, 2.
• During the headache excessive drawing, contracting, and crampy pains in the lower extremities, extending from the thighs to the toes; the pains appear to proceed from the bones as well as the muscles, 3.
• Hip.
• Pain in the left hip, only in the joint; it at times extends to the outside of the thigh; it is a sharp drawing pain, much worse on movement (first day), 1.
• Thigh.
• Transient crampy pain in the inner part of the thigh when walking (sixth day), 6.
• At 7 P.M., dull pain in the left thigh and under the left scapula (thirteenth day), 2.
• Aching of the left rectus femoris muscle and drawing in the right calf, at 11.30 P.M. (first day), 6.
• Drawing pain in the lower third of the left thigh (part of S. 559), 8.
• Drawing pain in the left hamstring, extending across the joint to the origin of the gastrocnemius, 9. [470.]
• Sharp stitches of pain, as of drawing or cramping of single fasciculi of muscle, about the origin of the gluteus maximus, on the left side; the stitches run in the direction of the hip-joint, 9.
• Continual jerking from the right sartorius muscle about the middle of the thigh, 9.
• Slight jerking about the middle of the rectus muscle of the right thigh, 9.
• Slight jerking in the vastus externus muscle of the right thigh near the knee, 9.
• Knee.
• When walking, a feeling in the knee-joint as if the relation of the bones were deranged, and they did not fit, as in a partial luxation (seventh day), 6.
• Pain under the right knee when walking, 5.
• Rheumatic pains in the right knee on walking, soon passing off (one hour after 15 drops, sixth day), 6.
• Sudden catch or twist on the inside of the patella, when sitting down to breakfast (eleventh day), 6.
• When the pains are felt above the knee, they are not felt below, and vice versâ, 3.
• Leg.
• A slight, sharp crampy pain in the left gastrocnemius, about the largest part of the muscle, 9. [480.]
• Excessive drawing and contracting pains in the gastrocnemius muscle of the left leg, which do not go off in a sitting posture as all the other pains in the limbs; no position relieves it, 3.
• At 3 P.M. sharp shooting pain in the right calf (thirteenth day), 2.
• Violent shooting pain in the leg in paroxysms, every one is more violent midway between the knee and ankle (first day), 1.
• Soreness of the gastrocnemii muscles, as if they had been beaten, 11.
• Ankle.
• Pain in the left ankle, with spasmodic contraction of the toes and drawing pains in them (first day), 1.
• Foot.
• Excessive crampy pains in the whole of the right foot, 3.
• Cramp in the instep of the right foot, 9.

GENERALITIES

• Objective.
• He was lying on the left side, 23.
• Tremulousness (accompanying profuse urination), 10.
• Trembling and weakness in the afternoon (seventh day), 7.* [490.]
• Trembling, with chill in the whole body, at noon (third day), 7.
• Shaking, trembling in the whole body, and whimpering (tingling) in the legs, as if asleep, in the afternoon (fifth day), 7.
• Muscles relaxed (after three hours), 28.*
• *Complets relaxation of the whole muscular system, with entire motor paralysis, 29.
• Mental and bodily inactivity during the afternoon (ninth day), 6.
• Listless and languid, 5, 29.
• At 10 A.M. I went to the Penn Hospital, where I saw a number of severe wounds; I am not usually affected much by the sight of wounds, but to-day, that or something else caused very unpleasant sensations; I became very weak, and my friend remarked that I was very pale, accompanied with nausea and trembling of the lower extremities ; these continued some ten minutes, but disappeared in the open air (sixth day), 2.
• When reclining, some languor and drowsiness (just before a heavy shower), (third day), 6.
• Languor and drowsiness on reclining for the purpose of study; slept and hour, and when aroused felt at first unwilling to move; less languor after stirring around awhile, in the afternoon (third day), 6.
• Great lassitude, 5.* [500.]
• General fatigue (eighth day), 4.*
• Easily fatigued, especially the lower limbs, 5.*
• Became tired and greatly exhausted very easily, 3.*
• Weakness at 12.30 P.M. (fifth day), 7.
• Weakness and a fluttering (part of S. 211), 7.
• *Weakness and trembling through the whole system, 5.
• Weak and dizzy (second morning), 24.
• Very weak, as after severe sickness, in the afternoon (eleventh day), 7.
• Great feebleness, 21.*
• Great prostration and muscular weakness, particularly of the elevators of the lower jaw and eyelids, and the muscles of the arm, 26. [510.]
• Great prostration, with irregular breathing and slow respiration (after five hours), 25.
• Complete prostration of the system, with emaciation, 1.
• Complete loss of muscular power ; was unable to move the limbs or even to raise his eyelids, although he could hear and was cognizant of all transpiring around him, 18.*
• Paralytic symptoms made themselves manifest through the muscular system, first experienced in the knee, and then in the inferior tibial region, increasing unto falling, 11.
• General restlessness, with chill after breakfast (fifth day), 2.
• Great restlessness (par of S. 257), 25.
• Subjective.
• General vigorous feeling at 8 A.M. (third day), 6.
• Sensation as though the blood had ceased to circulate, 13, 19.
• Feeling of lightness of the body and sense of instability of the whole system, 5.
• Feeling of relaxation of the whole body, especially of the hands and feet, with indisposition to move, 9. [520.]
• Inclination to lie down (after three-quarters of an hour), 17.
• Languid feeling of the whole body, especially of the hands and feels, 9.
• Feeling of danger of stumbling or falling, 5.
• One feels as though he had had "a fit of sickness," 5.
• General feeling of illness, as in fever, 5.
• Running in all "nerves," especially in the fingers, and a sensation of jumping, as from ant-bites, in the finger-ends; on looking at them, she found the nail blue halfway up from the root, at noon (third day), 7.
• Feels as if she had risen from a severe sick-bed in the forenoon (eleventh day), 7.
• Dull pains of a shifting character all day (thirteenth day), 2.
• Erratic pains of a rheumatic character (seventh day), 4.
• Fugitive or fixed pains here and there, 5. [530.]
• Drawing and aching pains, which seem to come from the bones, 3.
• In my own provings, I have frequently experienced a succession of acute, sudden, darting pains, evidently running along the single nerve branches in almost every part of the body and limbs, sometimes so sudden and acute as to make me start; at one time, a quick succession of these acute sudden pains coursed down the outside and front of the tibia for over half an hour, leaving a line of considerable tenderness marking its track, 5.
• The effects were dissipated within a few hours, 12.

SKIN

• Objective.
• Yellowness of the skin in the forenoon (eleventh day), 7.
• Pale yellow color of the face and of the whole body in the afternoon (eighth day), 7.
• Eruptions.
• Gelsemium produces a peculiar and very marked eruption in most of the provers; it appears most on the face, less frequently and less conspicuously on the back between the shoulders, etc.; it is papulous, very much the color of the eruption of measles, which it considerably resembles, but the papulæ are larger, more distant and distinct; although very conspicuous, they are attended with little or no sensation, the subject being unaware of their existence until he happens to see himself; persons have frequently been asked what was the matter, if they had the measles, etc., when they were not aware of the eruption; this generally appears on the second or third day of the proving, and would seem to be more constantly produced by the 2d or 3d dilution than by the tincture; the eruption continues one or two weeks, or longer, 5.
• Erythema of the face and neck, 13.
• Papulous eruption on the face, very nearly resembling measles, 13.
• A sore pimple on the left side of the neck at 8 A.M.; the pimple is sore, and has an areola embracing the diameter of a pea, quite red and inflamed (such an eruption not experienced at any other time), (sixth day). Two more pimples, on at the right corner of the os hyoides, the other at the left anterior temporal ridge, above the brow (eighth day). Another pimple, sore to touch, on the left side of the larynx; the first one less sore, like a small cutaneous induration; these are like minutes furunculi; thus far no suppuration (ninth day). The first pimple sorest, the other less so (tenth day), 6.
• Eruption of vesico-pustules, painless, but having no other analogy to measly, appeared on the inside of the thighs, 12.
• Subjective. [540.]
• Sudden stinging in the skin over the whole body, as if an eruption would break out, with greenish-yellow color of the skin, then burning, then itching, with profuse sweat, at 4 P.M. (eleventh day), 7 . [At fourteen years old she had a similar sensation, when she had a dangerous "Rösselausschlag," as they call it in Upper Austria, with sore throat, the body being densely covered with red granules, except the anterior part of the chest.

Rossalia squamosa?

Cf. Schmalz's Diagnost. Tabellen, 2014; or Scarlatina miliaris?]

• Itching about the elbows and forearms at 11.30 P.M. (first day), 6.
• Intense but transient itching of small points in the face and at the edge of the hair, on the forehead, right side, and elsewhere on the scalp, at 11.30 P.M. (first day), 6.

SLEEP AND DREAMS

• Sleepiness.
• Disposition to yawn; a sort of stupor; cannot keep the eyes open; is obliged to lie down and sleep, 5.
• Drowsiness in the forenoon, 9.
• Drowsiness, with dimness of vision; a kind of drunken stupor, 11.
• At first it seemed to cause drowsiness, afterwards aggravated the habitual sleeplessness, 12.
• Slightly drowsy (half an hour after first dose); increasing (forty minutes after third dose), 34.
• Sleepiness, like a lethargy, came on after 2 P.M., lasting all the afternoon and evening (seventh day), 7.
• Sleepiness and long and sound sleep are very general symptoms, 5. [550.]
• Inclined to sleep, with deep respiration and numbness of the whole body, 24.
• Early sleep after supper (seventh day), 6.
• Sound sleep until 7 A.M.; difficult, weary waking (second morning), 6.
• Sleeplessness.
• Sleeplessness the whole night (sixth night), 7.
• Wakeful till 1 in the morning, with desire to study; sound sleep the last half of the night and weary waking (third night), 6.
• Very little inclination to go to sleep, and when it does come on, he dreams much about business, etc., 3.
• Very restless night (first night), 2.*
• Very restless during the night, especially towards morning (forty-third night), 2.*
• Had a very restless night, with unpleasant dreams after midnight (first night), 2.*
• Could not get asleep for a long time; on falling asleep, a sort of nightmare awoke me again, so that no sleep came; at last it was like falling asleep, when a second time a kind of nightmare came on, never experienced before; it was as if the whole left side from the neck along the chest, trunk, and thigh, as far as the knee were a kind of soft muscle, spasmodically jerking up and down, somewhat with the elasticity of a mass of jelly; this motion extended deep into the interior of the chest, and the centre of this motion seemed to be in the region of the heart; it was, indeed, one great motion which concerned the whole left side as a mass, with the exception of the head and foot; this whole half of the body seemed to me to be going up and down, while the right side of the back, on which I lay, was quiet; I wondered in my mind at this turmoil going on in my body, but was unable to stir; when I wake up from this condition, I was well aware of what had happened, and found myself quietly lying on the same spot where I had fallen asleep, and the pulse, with everything else, was quiet; I certainly had not moved, and all, then, was my imagination; I only felt a drawing pain in te lower third of my left thigh, which was repeated the next day, 8.
• Dreams. [560.]
• Dreamy sleep and early waking (ninth night), 6.
• Dreams of working and of many people (first, second, and third nights), 7.
• Many dreams of hard work (seventh night), 7.
• During the night, much annoyed with unpleasant dreams (first night, after 6 drops), 2.

FEVER

• Chilliness.
• Cold on the surface, 21.
• Surface cold and congested, 23.
• Chilliness, especially along the spine, 15.*
• Transient chilliness (accompanying profuse urination), 10.
• Little chilliness, then some heat, then cold sweat, but less than before, all without thirst, between 2 and 4 P.M. (sixth day), 7.
• Febrile chilliness, with cold extremities and heat of the head and face, with headache, an early symptom in most cases, 5. [570.]
• Chilly sensations over the entire body, 1.
• Very chilly at 9 P.M. (sixth day), 2.
• Feels very chilly all day, especially in the morning (second day), 2.
• Chill (part of S. 490), 7.
• Chill after breakfast (fifth day), 2.
• Chill, then cold sweat more than yesterday, but not as much as before, in the afternoon, lasting till 5 P.M. (seventh day), 7.
• Chill, then weakness like fainting, then profuse cold sweat, after 2 P.M. (tenth day), 7.
• A tremor and a chill, which all of a sudden and urgently forced out a general cold sweat, so that the drops were seen standing on the arms quite densely (after hour hours and a half), 7.
• Slight chills during the day (fourth day), 2.
• "Every symptom of ague; would have thought he had the ague," 5. [580.]
• Feels anguish, with pain in and between the bones of the calf of the left leg; not able to go downstairs without holding to something, 5.
• Chilliness and chills running up the back from the loins to the nape of the neck, 11.
• Whilst reading exciting news, a transient chilliness on the upper half of the body, especially in the back and nape of the neck, at 3 P.M. (fifth day), 6.
• Extremities cold, 29 ; (after five hours), 25.
• Coldness of the extremities, especially the feet, often severe, 5.
• Extremities rather cold (after three hours), 28.
• Feet and hands cold, 19.
• Feet feel as if in cold water; this symptom occurs at an early stage, and is generally accompanied with heat of the head and face, and headache, 5.
• Heat.
• After one to several hours chilliness subsides, general heat supervenes, mostly about the head and face, with full pulse, from 80 to 100, 5.
• Directly after the chill comes a flying heat and pricking in the skin, rapidly followed by perspiration, which at times is profuse, and lasting even from twelve to twenty-four hours, 15. [590.]
• Warmth over the whole body, as if sweat would break out, then chilly down the back, in the afternoon (fifth day), 7.
• Feverish, in the forenoon (eleventh day), 7.
• Some heat and dryness of the hands, at 10 A.M. (third day), 6.
• Hands, especially the palms, hot and dry, in the afternoon (third day), 6.
• Feverish heat in the face (eighth day), 4.
• While usually in sickness she has cold feet, they are now constantly warm, in the afternoon (eighth day), 7.
• Sweat.
• Skin moist (after three hours), 28.
• In most cases perspiration follows the febrile reaction, and continues from a few minutes to several hours, 5.
• Walking or other movement easily induced perspiration (first day), 6.
• Free perspiration over the body (part of S. 257), 25. [600.]
• Perspiration sometimes profuse, and continuing from a few hours to twenty-four with languor and prostration, 5.
• Much sweat, with external coldness of the whole body, in the afternoon (eighth day), 7.
• A little cold sweat, chill, with hot running in the legs and burning of the soles of the feet like fire, without thirst, at 3 P.M. (fifth day), 7.
• During the stinging in the left breast, and after the chilly tremor, a profuse cold sweat broke out, more profuse than yesterday (second day), 7.
• A profuse cold sweat broke out suddenly (after the pain in the forehead), so that she was wet all over, still worse than the day before, and lasting until 6 P.M. (third day), 7.
• Skin dry (after five hours), 25.
• Palms dry and heated, at 11.30 P.M. (seventh day), 6.

CONDITIONS

• Aggravation.
• ( Morning ), After breakfast, vertiginous sensation; chilliness.
• ( Forenoon ), Feverish.
• ( Afternoon ), Heaviness of head; chilliness; general warmth, etc.
• ( Evening ), Aching in head; confusion of sight; when sitting cardialgia.
• ( After midnight ), All symptoms; towards morning, pain in bowels; pains in extremities; towards morning, restlessness; unpleasant dreams.
• ( Cool air ), Aching in trapezius muscle.
• ( Eating ), Aching in sacro-iliac regions, etc.
• ( Eating and drinking ), Especially warm things, the suffering.
• ( Lying down ), Pain in left side of neck; pains in hand, etc.
• ( Movement ), Especially in going upstairs, tendency to headache; aching in occiput; pain in hip.
• ( Sudden movement of head ), Lightheadedness, etc.
• ( Sitting ), Sensation in forearms, etc.
• ( When sitting down ), Catch on patella.
• ( After sleep ), Headache over front and top of head.
• ( Smoking ), Head symptoms.
• ( Stooping ), Stitches in middle of forehead; aching in occiput.
• ( Turning head ), Stitches in forehead.
• ( Turning eyes ), Stitches in forehead.
• ( Walking ), All symptoms; lightheadedness, etc.; pain in thigh; pain under knee.
• ( Warmth of bed ), All pains.
• ( While writing ), Headache on top of head, etc.
• ( After writing ), While walking, pain in bend of elbow.
• Amelioration.
• ( Closing one eye ), Confusion of sight.
• ( Holding finger before nose ), Confusion of sight.
• ( Movement ), Pains in muscles of extremities; languor.
• ( Pressure ), Sensation in sinciput.
• ( Reclining head and shoulders on high cushion while sitting ), Headache.
• ( Shaking head ), Aching in head.
• ( Sitting ), Headache; pains in limbs.
• ( Profuse urination ), Dullness of mind; headache; heaviness of head; dimness of sight.

SUPPLEMENT: GELSEMIUM. Authorities.

35 , W. F. Hani, Chicago Med. Journ., vol. xxv, 1868, p. 760, fatal poisoning of a child, æt. eighteen months, by an unknown quantity of the fluid extract; 36 , A. E. Hardin, Rich. and Louis. Med. Journ., June, 1873, p. 621, Dr. J. took about a tablespoonful of the tincture; 37 , Dr. Freeman, Lancet, 1873 (2), p. 475, a boy, æt. three years, took about 50 minims of the tincture (1 in 5), and died; 38 , same, a girl, æt. nine years, took a dessertspoonful of the tincture, and died in two hours; 39 , omitted; 40 , R. N. Taylor, M.D., Rich. and Louis. Med. Journ., 1875 (1), p. 609, a negro, æt. nineteen years took 15 drops of fluid extract at one dose upon an empty stomach; 41 , same, the writer took 5 drops of the fluid extract, and in two hours 10 drops more; 41 a , second experiment; 42 , same, a boy, æt. nineteen years, took 12 drops of the fluid extract; 43 , Ringer and Murrell, Lancet, 1876 (1), p. 661, and (2), p. 569, seventeen observations on six persons; 44 , Geo. S. Courtright, M.D., Cincin. Lancet and Obs., vol. xix, 1876, p. 961, Dr. Bennett, suffering from urticaria, took by mistake 1 to 2 teaspoonfuls of the tincture, and a little wiskey, cured by Morphia used hypodermically; 45 , Dr. Brewster, Hahn. Month., vol. xi, 1876, Mrs. V. took before breakfast a teaspoonful of a strong decoction of the root; 46 , W. Sinkler, M.D., Philad. Med. Times, vol. viii, 1878, p. 150, Mrs. T., æt. forty-nine years, took for neuralgia four doses of 5 drops each of the fluid extract; 47 , Ringer and Murrell, Lancet, 1878 (1), p. 858, Dr. J. B. Hill relates the case of five men taking from half a pint to a pint of the tincture each; 48 , same, ibid., p. 892, a woman, æt. from twenty-five to thirty years, took 15 drops of the tincture; 49 , J. G. Parsons, ibid., p. 953, G. G. P. swallowed about one drachm.

MIND

• Intellect was not impaired at any time, but was slightly confused, 44.
• Aroused with difficulty, 35.
• Loss of consciousness, 49.

HEAD. [610.]

• Giddiness (soon), 49.
• Giddiness was another prominent and early symptom. Some felt it over the whole head, but by far the larger number said it was limited to the brows. Stranding or walking made it much worse. When well marked the patients staggered, and were afraid even to stand, much less to walk. So giddy was one patient that he nearly fell off the form. Some described their heads as going round and round. They felt and seemed drunk, though without any incoherence, still less mental excitement, 43.
• Pain in the head and eyes. Patients described this pain variously. It was generally limited to the forehead, and most marked just over the eyes. Some called it a dull sensation over the eyes; others a heavy pain; and others a giddy pain; and one patient experienced pain over the occiput, with a sensation as though the crown of the head were being lifted off in two pieces. This headache was sometimes absent, and sometimes followed instead of preceding the other symptoms. Dull aching pain in the eyeballs, now and then shooting in character, occasionally worse in one ball, sometimes followed and sometimes preceded the headache. The headache and pain in the eyeballs, intensified on moving the eyes, were often severe. When ptosis was well marked, the effort to open the eyes widely caused considerable pain, and the patient seemed to get relief by closing them, 43.
• I found the doctor sitting on the edge of a lounge, being held by two persons, with the head falling forward, the chin resting on the breast; I at once had his head raised up, but it immediately dropped forward again on letting go of it, showing that the parts were paralyzed; at breakfast his chin had dropped down, and it was with difficulty he could keep his head from falling on the table; could not eat, and with difficulty, on account of his head falling forward, walked into the next room, 44.
• Persistent and distressing numbness in the occipital region, which lasted for some hours after the consciousness returned, 49.

EYE

• Eyes closed, 47.
• Eyes staring, 48.
• Strabismus, 49.
• Dropping of the eyelids, especially the left, 49.
• Pupils large and dilated, 35. [620.]
• Pupils largely dilated and insensible to light; eyes had a fixed stare; sclerotic congested; lids drooping, so that it was necessary to pull them apart to see the eye, 44.
• A few drops of the solution of the alkaloid were put into one eye, and in each case the trial pupil became widely dilated, the dilatation usually beginning in about thirty minutes. Not only does the pupil dilate, but the muscle of accommodation becomes paralyzed and the sight affected. In twenty-four hours vision again becomes nearly natural, but the pupil remains dilated much longer, sometimes, indeed, for a week, or even a fortnight, 43.
• Dimness of vision, 38, 40.
• Vision slightly indistinct, 42.
• Some difficulty in sight before he had walked two squares, 44.
• In every case the sight was affected. At first the sight without being misty, is not as clear as usual; then slight mist comes before the eyes, one patient comparing it to "a lot of smoke rising before his eyes," and another to a "thick veil." The sight at last becomes so affected that it fails almost completely, failing first with distant objects, then, as the sight becomes more impaired, nearer and nearer objects become hazy, 43.
• Double vision, 37, 38.
• The drug seems to produce two kinds of diplopia, one much more persistent than the other. As to the transient kind, we find it on many occasions a very passing phenomenon, lasting only a few seconds, then disappearing, then, after a few minutes, reappearing. In this form images in the median vertical line appeared double, distant objects at first undergoing the duplication. Sometimes the patient was conscious that the diplopia was coming on; thus one woman said: "I know that it is now coming on; I feel such a heavy weight under my upper eyelid." The double vision then came on, and, with the heaviness, ceased in a few seconds. One image was higher than the other; in this respect the images varied much. The following descriptive notes were taken down rapidly from the patient, the phenomena occurring as fast as they could be written: "One gas-jet appears about six inches above the other, and there is six inches above the other, and there is six inches between them horizontally; the upper one is to the left; now the right is upper most; now the left slightly again; going over to the right now again; exactly over one another now, and quite close together; now again separated, left the highest; now over one another." With other patients the two images seemed on a level. Sometimes the drug produces only this transient kind of diplopia; at other times both kinds; and sometimes one kind preceded the other, the transient usually preceding the more constant form, and continuing to recur from time, while the constant form lasted. The phenomena of the constant form of diplopia follow a definite order, and take place in the upper half only the field of vision. They occurred first with objects held at the extreme right or left of the visual field; and as the patient passed more under the influence of the drug, then with objects held nearer and nearer the middle line, and at last, usually for a short time only, objects in the median vertical plane seemed double. As the effects of the drug wore off, the double vision disappeared in the inverse order. The outer lateral image was the higher, and the further the object was carried to the right or left the greater was the horizontal and vertical distance between the images. When a colored glass was placed before either eye, the outer and higher image was seen by the covered eye. When the object was carried high above the head, the two images gradually coalesced, and the object looked very much thinner, "like a thread." With well-developed diplopia there is impaired movement of the eyeball, chiefly affecting, as far as we could ascertain, the external and internal rectus, especially the external, for the outward and inward movement of the eyeball was less free than before the action of the medicine. The ball appeared to be moved by greater effort, so that when carried as far as the weakened muscles are capable, the ball oscillates, as though the patient with great effort moved it as far as he could, and then the tired muscles gave way a little, but being roused to an effort they carried the eye back again; the frequent repetition of this effort gave rise to an oscillation. The external rectus is generally first affected, and not unfrequently one rectus sooner and in excess of the other. Even when the diplopia is strongly marked, the loss of power over the muscles is not very great, and there is no obvious squinting. Then, as the patient becomes still more affected, ptosis supervenes, and a great part of the whole of the upper half of the field of vision is cut off. The loss of power in the eye-muscles is then more marked, but without the occurrence of obvious squinting. At this time the symptoms no longer follow the order previously described, but assume various phases, often changing rapidly. Thus, whilst on one side the outer image is the higher, if the object is carried to the other side of the field the inner image becomes the higher; or, perhaps, for the first few seconds the outer and then the inner is the higher, 43.
• Visionless (after one hour and a half), 36.

FACE

• Face congested, 44, 49. [630.]
• Face and lips blue and livid, 35.
• Lips of a livid color, 44.
• Jaws rigid, 48.

MOUTH

• The mouth was partially open, and the lower jaw hanging as an almost useless appendage; could move the tongue slightly, but unable to articulate distinctly, 44.
• Paralysis of the muscles of the mouth and throat, 49.
• Foaming at the mouth, 48.
• Interior of mouth and fauces moist, 44.
• Muffled speech, 49.
• Speechless (after one hour and a half), 36.

THROAT

• Difficulty of swallowing, 44. [640.]
• Deglutition impossible, 49.

STOMACH

• Considerable nausea (in three hours), 40.
• Retching and vomiting, 35.

URINARY ORGANS

• Abundant flow of urine, this secretion having been scanty for a few days (in five hours), 41.

RESPIRATORY ORGANS

• Expectoration of a thick yellow pus for six or seven days, 44.
• Respirations slow, 44.
• Respiration 20 (before experiment); 14 (in three hours and a half); 12 (in four hours and a half), 41.
• Slow, catching respiration, 48.
• Difficulty of breathing, with oppression in the præcordial region; the difficulty of breathing rapidly increased, consisting of a series of short and rapid inspirations, followed by three or four prolonged gasps, 49.
• Struggles for breath, 46. [650.]
• Thought he was going to die from suffocation, until I had his head thrown back, when he said the air rushed into his lungs and relieved him for a time, 44.
• Respiration scarcely perceptible, 47.

CHEST

• Pain in chest, 48.

HEART AND PULSE

• Pulse 98 to 100, and very weak, 44.
• Pulse 83 (before experiment); 78 (in three hours and a half); 53, rose to 65 on walking across the room (in four hours and a half); 53 (in five hours); 63 (in five hours and a half), 41.
• Pulse 87 (before experiment); 64 (in three hours); 84 (in four hours), 40.
• After the lapse of one hour the pulse had fallen twenty beats per minute, 42.
• Pulse weak, 47.
• Pulse slow, 48.
• No pulse at the wrist or carotids, 35. [660.]
• Pulseless at the wrists (after one hour and a half), 36.

SUPERIOR EXTREMITIES

• Could not pour coffee from a cup, 44.
• Complete insensibility to pain in both arms, 44.

INFERIOR EXTREMITIES

• Staggering fait, 37.
• Weakness in knees (in four hours and a half), 41, 42.

GENERALITIES

• Paralysis, 47, 48.
• Extremities cold, the pulse small and feeble, respirations sighing and jerking, pupils dilated, and the eyes suffused. There was paralysis of the bladder, the urine dribbling away constantly, and although there was general muscular enfeeblement, it was most marked on the right side, in the arm, and leg, 45.
• In a few minutes she said she could not see; her head felt strangely. She took an emetic of mustard, which caused vomiting before the writer arrived. Found the patient in the following condition; Could not see; the blindness was complete. Neither could she talk or swallow; the glottis was spasmodically closed. She could moan, which she did almost continually; but the power of articulation was gone. Great trembling, with anxiety; was afraid she was going to die, and was very anxious to know if anything could be done. Face swollen and of dark color; eyes distended; pupils dilated; great prostration; pulse small and rapid; tongue and throat very dry, 43.
• At 4.30 P.M., having swallowed two ounces of whiskey, with a view to its stimulating action upon my pulse, and having walked rapidly some distance, I had a full, strong pulse of 100 per minute, my normal pulse being 85 per minute. I injected under the skin of my left arm five minims fluid extract. I examined my pulse at 5 o'clock, and it had fallen to 84; vision a little indistinct; at 5.30 pulse was down to 80 beats per minute; vision more disturbed. At 6 o'clock pulse 76, and temperature 98 1/5°; disturbance of vision very great. It seemed almost impossible for me to fix my gaze upon any object, and when I succeeded in doing so, the object, whatever it happened to be, would fade away at first, and then reappear again. There was a sensation of fulness in my head, and a feeling of great weight and heaviness about the eyelids. When I opened my eyes to their fullest capacity, it seemed as through they were but half open. At 6.15 pulse was 72, no change in the other symptoms. At 6.30 pulse stood 69. At 7 o'clock I partook of a light supper. At 7.45 pulse was 60, and respiration 15; no change in temperature. The disturbance of vision completely passed off at 8 P.M., after which time no uncomfortable symptoms were experienced. At 8.15 pulse 60, respiration 15, and temperature 97 2/5°. At 8.45 pulse 59, and temperature 97 2/3°. At 9.15 pulse 60. At 9.45 pulse 60, and temperature 97 2/5°. I then arose from the half reclining position which I had occupied during the experiment, and walked across the room rapidly for five minutes. On resuming my former position, my pulse during the first minute indicated 67, but in ten minutes it had fallen again to the old rate of 60 per minute. The temperature was not at all affected by the exercise the thermometer recording 97 2/5° as before. At 10.30 pulse 58, and temperature 97 1/5°; at this time I passed eight ounces of rather high-colored urine. I now ascended two flights of stairs and returned, but there was no increase in the pulse or temperature produced by the exercise. At 11 P.M., pulse 63, and temperature 97 1/5°; the former very soft and compressible. At 11.30, pulse 60, and of the same character; temperature 96 3/5°. Retired at 12.30, and slept soundly for five hours. Awaking at 7.30 A.M., I about several times, after which my pulse was 61, irregular and compressible; temperature 97.4°. During the forenoon I passed an unusually large quantity of urine, and my pulse did not regain its normal force and frequency until 10 o'clock in the morning, 41a.
• Vital capacity, average, 185 (before experiment); 217 (after first dose); 230 (after second dose); 237 (after third dose); 236 (after fourth dose); 230 (after fifth dose), 43. [670.]
• Vital capacity, average, 175 (before experiment); 175 (after first dose); 190 (after second dose); 185 (after third dose), 43.
• Vital capacity, average, 193 (before drug); 209 (after first dose); 207 (after second dose); 205 (after third dose), 43.
• Muscular strength, average, 75 (before experiment); 76 (after first dose); 67 (after second and third doses); 68 (after fourth dose); 64 (after fifth dose), 43.
• Muscular strength, average, 87 (before experiment); 65 (after first dose); 75 (after second and third doses), 43.
• Average muscular strength, 89 (before experiment); 87 (after first dose); 79 (after second dose); 80 (after third dose), 43.
• A sensation of general weakness and relaxation pervaded the entire system. Upon attempting to walk, the gait was at first slightly staggering, resembling that of intoxication (in three hours), 40.
• Loss of muscular power, 38.
• Complete muscular relaxation, 37.
• Any movement or touch of the head (which seemed greatly enlarged) most intensely aggravated all the distressing symptoms, as also did the application of any fluid to the lips, the dread of which was nearly equal to that evinced in hydrophobia, 49.

SLEEP

• Drowsiness (soon), 49.

FEVER. [680.]

• Temperature 98 1/2° (before experiment); 95 2/5° (in three hours), 40.
• Extremities cold, 48.
• Profuse perspiration, 49.