Sanguinaria Canadensis, Linn.

Natural order , Papaveraceæ.

Common names , Blood-root, Puccoon, etc.

Preparation , Tincture of the root.

Authorities. (Nos.

1 to 6 , from Dr. Downey's Thesis).

1 , Dr. William Downey, Inaugural Diss, "An Experimental Inquiry," etc., Philadelphia, 1803, two hours after breakfast took 20 grains of recent root; 1 a , same, took 8 grains of "the saponaceous or extractive matter;" 1 b , same, took 8 grains of the resin; 1 c , same, took 8 grains of leaves made into pills; 1 d , same, took 4 grains of extract obtained by decoction with water; 1 e , same, "having procured 2 drachms of immature seed-vessels and seeds, 6 ounces of water were boiled with them and evaporated to 2 ounces; of this I took 2 drachms, repeated after twenty minutes, and 3 drachms after forty-five minutes;" 2 , same, proving by Mr. Young, took 23 grains of powdered root made into pills with honey; 2 a , same, took 8 grains of aqueous extract; 3 , same, proving by Mr. Rees, took 8 grains of alcoholic extract of dried root; 4 , same, proving by Mr. Bartram, took 8 grains of gummous extract; 5 , same, proving of Mr. Pendergrast, who took 4 grains of powdered leaves; 6 , same, proving of Mr. Woolton, who took 5-drachm doses of the decoction; 7 , Dr. William Tully, Prize Essay (American Med. Recorder, Jan. 1828), effects of the continued use of the tincture; 7 a , same, in Bost. M. and S. Journ., 1832, 6, 243, general effects; 7 b , same, proving of Dr. Terry, who took a scruple of the Tartrate of san guinarin at once; 8 , Smith, Lond. Med. Trans., Vol. 1, general effects; , Bird, Dissertation on Sanguinaria, N. Y., 1822, and other American authors, general effects. ( to , provings from Hering's Compilation, N. Archiv f. Hom., 2, 2, 114); , Bute, effects of 1st dilution; , proving by Dr. Freitag, "K.;" , same, "K. &;" , Jeanes, symptoms observed after expressing the juice; , proving by Dr. Husemann with 6th dilution, "J. H.;" , same, 6th dilution, "F. H.;" , N. Y. Journ. of Commerce (Am. J. of Med. Sc., 1841, 2, 506), "three women and one man drank a large quantity of the tincture; all died the next day;" , Dr. George D. Gibbs, Glasgow Med. Journ., 1860, p. 121, general effects; , fatal effects in three women (compare No.

16 ); 19 , Dr. Tinker, Trans. Am. Inst. of Hom., 1870, proving with tincture of dry root, 10 drops first and second days; 20 , Dr. B. Fincke, from "Compilation by Dr. A. K. Hills," N. Am. J. of Hom., N. S., 3, 359 (symptoms); 21 , Dr. M. McFarlan, symptoms (from Hills); 22 , Dr. Henry H. Pilling, Thesis, proving with tincture of fresh root, repeated doses for eighteen days, increasing from 5 to 150 drops; 22 a , same, "on the fifth day, after all effects had disappeared, took 200 drops of tincture;" 22 b , same, "three weeks later took tincture for fourteen days, repeated doses of 25 to 500 drops."

MIND

The depressing sensation on the nervous system not so marked as yesterday (fourth day), 19.
Great anxiety, 7.
Great anxiety before vomiting, 10.
Extreme moroseness, 10.
Very irritable and morose, and impatient at the least trifle, with severe dyspnœa, in the afternoon (third day), 19.
Irritable, easily excited (first day), 20.
Irritability, in the morning; she could break things to pieces without any cause (fourth day), 20.
Inability to fix the mind on any subject, in the afternoon (second day), 19.
Inability to attend to any business during the fever (third day), 19. [10.]
The stupor continues, making it almost impossible to continue my studies (ninth day), 22.

HEAD

Vertigo.
That terrible vertigo, which had been so prominent during the whole proving, returned (after one hour, first day), 22a.
Vertigo, in the morning (fourth day), 22.
Vertigo, immediately (ninth day), 22.
Vertigo on rising from a sitting position (after the dose, twelfth day), 22.*
The vertigo, which had partly left immediately returned (after the dose), with a dull heavy feeling in the stomach, as if caused from some hard substance there (sixteenth day), 22.*
Distressing vertigo (eighth morning), 22a.*
Vertigo and headache in the forehead, as from coryza, with sneezing and vomiturition; (perhaps increased by lime used for whitewashing, which always caused her headache), (sixteenth day), 20.
Vertigo, long continuing, with debility, 10.
Vertigo, with sounds in the ears, immediately, 10. [20.]
*Vertigo, 7a, 18.
Stagger as if intoxicated (after the dose, twelfth day), 22.
Very dizzy, immediately (seventh and fifteenth days), 22.
Head feels dizzy and cannot turn quick, without fear of falling , in the afternoon (second day), 19.*
Head is dizzy at times, and vertigo and faintness on rising quickly from a stooping position, or turning the head quickly, in the morning (fourth day), 19.*
General Head.
Confused and dull feeling in the head, which became better after eructation (soon), 10.
Heaviness in the head, from the vertex to the middle of the forehead, with pressing in the glabella and buzzing in head; eyes have a dull expression (fifth day), 20.
Heaviness of the brain, 10.
Head feels dull and inclined to ache in the temples, right side most (after one hour), 19.*

EYE

Redness of the eyes, in the morning (eighteenth day), 20.
Staring and protuberance of the eyes, 7a.
The eyes are sunken, dull, and burning, with slight injection of the bloodvessels (seventeenth day), 20. [100.]
Dimness of the eyes, in the afternoon, with a feeling as if there were hairs in them, 10.
At first dryness and violent burning in the eyes, with difficulty in opening the lids, then copious lachrymation with burning, as from hot tears, in the evening (fourth day), 20.
Burning dryness in the eyes (third day), 20.*
Burning dryness in the eyes wakes her from sleep (fourth day), 20.
Eyes feel very weak and lids smart on closing them tightly, and tears start if opened to the ordinary light of day; eyeballs tender to the touch (third morning), 19.
Sensation as of acid fumes in the eyes, 15.
Pressive pain in the left eye, 12.
Pain in the right eye, 10.
A pain suddenly shoots into the inner corner of the right eye and thence to the forehead, 10.
Pain over the eyes (twelfth day), 22b.* [110.]
Dull pain directly over the eyes (after seventy-five minutes), 1d.
Lids.
Stitches in the upper lid, 12.
Lachrymal Apparatus.
Profuse lachrymation of the right eye, which is especially painful to touch, soon followed by fluent coryza, with flow of clear water from the right nostril; afterwards, in the evening, two diarrhœa-like stools, followed by cessation of all symptoms (after five hours), 10.
Profuse lachrymation of the right eye, that is painful to touch, followed by coryza, 10.
Lachrymation, with burning in the eyes, 10.
Ball.
Both eyeballs very sore, with frequent sharp piercing pain darting through them, with dimness of sight (after three hours, second day), 19.
Right eyeball very painful, especially on attempting to roll it outward or upward, in the afternoon (second day), .

EAR

Pains in the ears, with headache, 10.
Pain deep in the left ear, only for a short time, during the pain in the forehead, 13.
Slowly sticking pain in the left ear (after ten minutes), 13.
Every stroke of a hammer heard near a blacksmith's shop is painful in the right ear, 10.
Throbbing under the ears at irregular intervals, often only two single beats, 10.
Cracking in the right ear, noticed while stroking the right cheek with the finger tips (third day), 15.
Beating whizzing in the left ear, 10.
Singing in the ears, with vertigo, 10.
Humming in the ears, with determination of blood, 10.

NOSE. [140.]

Profuse fluent coryza in the right nostril, 10.
Fluent coryza, with frequent sneezing, 10.
Watery acrid coryza, making the nose sore, 10.
Alternations of fluent and dry coryza, 10.
Painful coryza, during the fever (fourth day), 19.
Dry coryza, as from a sudden cold (thirteenth day), 22b.
Much sneezing, 10.
Sneezing very frequently, with tingling in the nares (after three hours, second day), 19.
When snuffed up the nostrils it proved stenutatory, and left a sensation of heat for some time, 8.
Snuffed into the nose it excites sneezing, and an increased secretion from the Schneiderian membrane, 7. [150.]
Dull heavy pain at the root of the nose, with a dizzy sensation, somewhat like the effect of alcoholic stimulus, with same feeling of lassitude (after six hours), 19.
Dull heavy pain about the root of the nose, with considerable coryza; with stinging sensation in the nose, causing considerable rubbing (second day), 19.
Dull pain at the root of the nose, with tingling sensation like coryza, in the afternoon (second day), 19.
Severe pain about the root of the nose (third day), 19.
Sensation of heat in the nose, 10.
Odor of roasted onions in the nose, 10.
Aversion to the smell of syrup, 10.
Loss of smell and taste, 10.

FACE

Peculiar haggard expression of the countenance, 7a.
Face flushed (after twenty-five minutes), 1c. [160.]
Redness of the face, 10.
Countenance pale (after forty-five minutes), 6.
Face very pale (after forty minutes), 1.
Paleness of the face, with disposition to vomit, 10.
A worn appearance (seventeenth day), 20.
Puffiness of the face, with bright redness and feeling of stiffness, 10.
Pale swollen countenance around the eyes and temples, more on the left side (sixth day), 20.
Feeling of fulness in the face, 10.
Violent burning heat and redness of the face, 10.
Severe pain in cheek-bones (third day), 19. [170.]
Towards evening, swelling of the lips (fourth day), 20.
The under lip burns, is swollen, hard, and becomes covered with blisters, which dry up next morning and form crusts, which drop off after four days (fifth day), 20.
Sensation of dryness of the lips (in three provers), 10.
Stiffness of the jaws, 10.
Jerking in both superior maxillary bones, extending towards the eye, 10.

MOUTH

Teeth.
Looseness of the teeth, 10.
Toothache when picking the teeth, 10.
Pain in the upper teeth, 10.
Pain in a hollow tooth, especially when touched by food, 10.
Pain in the right lower hollow molar after cold drinks, two mornings in succession, 15. [180.]
Awoke with toothache in a right upper hollow tooth, and headache in the right side of the forehead, extending into the ear; the toothache was aggravated by cold water (and also by hot drinks), but relieved by warm water, 14.
A slow short and long-thrilling sensation, ending in a gnawing, in an upper molar (after twenty minutes), 13.
Pain in one or several incisors and in a hollow molar (after twenty minutes), 13.
Gums.
Sores on the gums and roof of mouth (Fincke, 10m), 21.
Tongue.
Yellowish white coating on the tongue, with bad taste in the mouth (second day), 22a.
Light yellow coating on the tongue, in the morning (fourth day), 22.
Tongue coated yellowish white (eighth and ninth days), 22.
Tongue coated white, with loss of appetite, 10.
Tongue feels burnt, 11.*
Crawling in the tip of the tongue, followed by an astringent sensation that extended over the whole tongue, on waking (first day), 14. [190.]
Prickling on the tongue and hard palate, as if he had been chewing Mezereum (after twenty-five minutes), 13.
Dry and raw sensation of something acrid, beginning in the right side of the tongue and extending over the whole tongue, soon after waking, in the morning, 15.
Stitches in the left side of the tongue, 15.
Prickling in the tip of the tongue (after fifteen minutes), 13.
General Mouth.
Mouth clammy and feverish (second day), 19.
Mouth clammy, with very disagreeable taste, with abundant accumulations about the teeth, and very fetid breath (third morning), .

THROAT

Feeling of swelling in the throat on swallowing, 10.*
Sensation as if the throat were completely closed by swelling, with pain on swallowing, as if he would suffocate , with loss of voice (after three hours), 10.*
Pain, with sensation of swelling, in the throat, worse on the right side, and especially on swallowing, 10.*
Throat very dry, with tickling cough (after three hours, second day), 19.* [210.]
Dryness in the throat, with a teasing dry hacking cough, in the afternoon (second day), 19.*
Dryness of the throat , not relieved by drinking, 10.*
Throat feels raw; some difficulty in swallowing; mouth and throat feel almost denuded of mucous membrane ; in the morning, at 12.30 P.M., mucous membrane of mouth, fauces, etc., very sensitive, as if having held very hot water in the mouth, making it quite difficult to masticate food (fourth day), 19.*
A spasmodic constriction directly beneath the lower jaw and across the throat, very distressing in character, lasting for two or three hours, in the afternoon (second day), 19.
Tickling in the throat, with hacking cough and headache, in the evening, 11.*
Transient, very peculiar feeling in the throat, as though he had swallowed something sharp (after twenty minutes), 13.
Heat in the throat; inspiration of cold air is very agreeable; in the evening, from 6 to 7 P.M., 15.
Burning in the fauces, after eating sweet things, 10.
A small quantity dissolved in the saliva and swallowed, produces considerable irritation in the fauces, which continued for several hours, (Aqueous extract.), 1.
Burning sensation in fauces, especially on soft palate, extending downward to about centre of the sternal region, in the afternoon (second day), 19. [220.]
Warming sensation in the fauces, and especially on soft palate, with slight relaxation (after fifteen minutes), 19.
Burning in the pharynx, 10.

STOMACH

Appetite and Thirst.
Craving appetite; could not eat enough to satisfy my hunger; in the morning (fourteenth day), 22b.
Appetite craving, in the morning (twelfth day), 22.
Ate quite heartily in morning (eighth day), 22.
Longing for indefinite things , with loss of appetite, 10.*
Longing for spiced food, 10.*
Appetite poor (sixth day), 22.
Appetite very much impaired (second day), 19.
No appetite for breakfast (seventh day), 22. [230.]
Almost a total loss of appetite (third morning), 19.
Loss of appetite, with uncertain cravings, 10.
No desire for food (fourth day), 19.
Loss of appetite, 16 ; (sixth day), 20.
Sometimes violent, though transient, gastrodynia, 7a.
Aversion to butter, which leaves a sweetish taste, 10.
Tormenting thirst, 16, 18.
Eructations.
Frequent eructations of a bad odor, with some qualmishness and paleness of the face, 10.
Spasmodic eructations of air, 10.
Eructations of gas, followed by tickling in the throat, provoking cough, immediately, 10. [240.]
Regurgitation and disposition to vomit, 10.
Flatulent eructation, 10.
Eructations of wind from his stomach (after forty-five minutes), 3.
Hiccough.
Hiccough on smoking, 15.
Nausea and Vomiting.
Deathly nausea, with much salivation, 10.*
Nausea while sitting at the breakfast table (thirteenth day), .

ABDOMEN

Hypochondria.
Pain in the hypochondria, violent, persistent; vertigo and weakness, 10.
Pain in the hypochondriac region and right side of chest is severe (second day); almost as severe (third day), 22a.
Dull burning pain in right hypochondriac region and chest (right side), in morning (seventh day), 22.
The pain in the hypochondria is quite severe (ninth day), 22.
Awoke in the morning with a severe pain in the region of the spleen (fifteenth day); this pain continues (sixteenth, seventeenth, and eighteenth days), 22.
Pain in the hypochondrium (left), very severe (eighth, ninth, and tenth days), 22b. [330.]
The pain in the spleen was often distressing, but I did not notice any enlargement of that organ, but a constant soreness upon pressure, 22b.
Umbilicus and Sides.
Griping in the umbilical region, lasting two hours (after three hours and a half, third day), 22.
Griping pain in umbilical region, the remained of the day (after two hours, sixth day), 22.
Severe griping pains in umbilical region, with considerable flatulency and fulness in the head, at 5.30 P.M. (seventh day), 22.
Griping in the umbilical region (eighth and ninth days), 22.
Painfulness of the abdominal walls as if ulcerated, with burning around the navel, as if it was chafed (eighteenth day), 20.
Twisting pain in the left side, not far from the pubis and crest of the ilium, worse while sitting, standing, and bending towards the right side; also on pressure; better on walking erect; the pain afterwards extended from this place around to the left hip and up behind the short ribs; especially noticed on bending to the right (eighth day), 15.
General Abdomen.
Discharge of flatus, then of excrementitious matter, with abatement of the nausea, etc., 13.
Frequent emission of very offensive flatus, afterwards, in the evening, a hard stool follows, 10.
Flatulency (eighth and ninth days), 22. [340.]
All night, colic as before the menses, 10.
Paroxysmal colic, .

RECTUM AND ANUS

There is still, at times, the return of that distressing, cutting, spasmodic sensation low in the rectum, in the evening (third day), 19.
Ineffectual desire for stool, followed by vomiting, 10.
Ineffectual desire for stool, with sensation of a thick mass in the anus; the sensation was repeated several times during the day without stool, 10.
Frequent desire for stool, with emission of only flatus, in the afternoon, 10.
Desire for stool, with emission of much flatus, 10.

STOOL

*In the evening, diarrhœa, with disappearance of the coryza, 10. [360.]
Diarrhœa stool after the colicky pain, 10.
Diarrhœa like stool mixed with much flatus, 10.*
Stool at first of wind, afterwards of a very scanty discharge of fæces, relieving the desire for stool (after twenty-five minutes), 13.
Purged gently two or three times (after about three hours), 1.
Single watery stool after severe cutting pain in the bowels, 10.
Five natural evacuations in one day, 10.
Two scanty stools (first day), 15.
Undigested stool, 10.
Stools soft (first days); hard (latter days), 15.
The discharge from the intestine was noticed to contain a very unusual quantity of bright-yellow bile, 7b. [370.]
Evacuation of the bowels semisolid, with considerable griping before stool (twelfth day), 22.
It produced only two motions and those very gentle, 2a.
It is remarkable that though Sanguinaria does not seem to be capable of purging, or even of proving directly laxative, yet when taken in large quantities by itself, and for a considerable length of time, it will, for the most part, obviate habitual costiveness, and even when conjoined with Opium, it will not unfrequently prevent any constipating effect from that article. Whether it was employed with or without Opium, the fæces became of a bright-yellow color, and a free state of the bowels took place, 7.
Bowels constipated (sixth day), 22.
Bowels constipated; fæces natural in color, but in hard lumps, in the morning (eighth day); constipation continued (ninth day), 22.
Bowels remain constipated (thirteenth, fourteenth, and eighteenth days), 22.

URINARY ORGANS

Pain from the kidneys seems to penetrate into the right iliac fossa, and then to shoot through to the sigmoid flexure of the colon, then extending down to the rectum (after three hours, second day), 19.
Dull heavy pain across the kidneys (third morning), 19.
Pain in the bladder (thirteenth and fourteenth days), 22b.
Some difficulty in discharging urine, having somewhat of an ardor urinate, 2, 2a. [380.]
Increased desire to urinate, voiding only a little at a time, but as often as every hour during the day (eighth and ninth days), 22.
Constant desire to urinate, but there is not any increase in the amount of urine voided (twelfth day), 22b.
Frequent micturition, even at night, 10.
Frequent micturition at night, always of much watery urine, 10.
Urinate often, quantity natural, color dark-yellow (thirteenth day), 22.
In the evening, the urine is a little more copious than during the day, very high-colored, and throws down a reddish sediment on standing (third day), 19.
Increase in the quantity of urine (ninth and tenth days), 22b.
The urine increases in quantity about one-half and was voided often (first day), 22a.
Increase in the quantity of urine (ninth and eleventh days), 22.
Urine higher-colored, and not quite as easily voided (third morning), 19. [390.]
Urine scanty, red, and high-colored, in morning (eighth and ninth days), 22.

SEXUAL ORGANS

Male.
Burning sensation in the glans penis (twelfth day); the pain continues (thirteenth day), 22b.
Emissions two nights in succession, after which he felt very well, 15.
Female.
Menses appeared a week too early, with black blood, 10.
Sometimes it excites the catamenial secretion, and it has occasionally been known to produce uterine hæmorrhage, 7.
*Menses much more profuse than usual, with less pain and weakness in the small of the back than usual; but with headache in the right side of the forehead and side of the head, with a sensation as if the eyes would be forced out of the head, worse in the right eye (second day), 14.
Catamenia at the right time; very offensive putrid smell, bright red; the blood deposits clots in the vessels like lumps of flesh; towards the end the blood became darker, and the offensive odor abated; the first four days the flow was very copious, and the catamenia lasted ten days (seventh day), 20.
Cessation of the menses (fifteenth day), 20.

RESPIRATORY APPARATUS

Voice.
Aphonia, with swelling in the throat, 10.
Cough and Expectoration.
A dry cough, awakening him from sleep, which did not cease until he sat upright in bed, and flatus was discharged both upwards and downwards, 10.*
*Dry cough, with considerable tickling in throat-pit, and a crawling sensation extending down beneath the sternum; cough becoming very severe, causing considerable pain beneath the upper part of the sternum, with no expectoration; lasted about two hours (second day), 19. [400.]
Dry cough, and some pain in the chest, in the morning (third day), 20.
Dry cough, caused by incessant tickling in the stomach, with shortness of breath, for fifteen minutes (fifth day), 20.
*Teasing, dry, hacking cough, with dryness in the throat, in the afternoon (second day), 19.
The dry hacking cough was persistent after the proving, 19.*
Frequent hacking cough, especially while eating, for several days, 14.
*Hacking cough caused by tickling in the throat, several evenings after lying down, 14.
*Hacking cough, 10.
Paroxysm of coughing, which lasted about ten minutes, in the morning (eleventh day), 22.
Slight cough, 10.
*Tickling cough with very dry throat (after three hours, second day), 19. [410.]
Slight cough, caused by a tickling sensation in the larynx, with expectoration of a thick tenacious mucus (second day), 22a.
It sometimes promotes the excretion of mucus, or muco-purulent matter from the bronchial membrane, and sometimes it restrains these discharges, according to the different circumstances of the case, 7.
Respiration.

CHEST

Constant pressure and heaviness in the whole of the upper part of the chest, with difficulty of breathing, 18.*
Pressive pain in the chest and back, 10.
Severe pain in the chest under the fifth rib (thirteenth day), 22b. [420.]
The pains in the chest were rather peculiar; while they were deep they were not as sharp as I had supposed pleuritic pains to be; nor was there any soreness in the pectoral muscles; the pains were as severe on one side as the other, but never on both sides at once, 22b.
Slight pain in the chest (after nine days), 22.
A simple pain in the thorax, 10.
Soreness in the chest felt during inspiration (ninth day), 22.
Pain under the shoulder-blade with chill, 10.
Front and Sides.
The pain beneath the sternum and in the right breast continued very persistent during the whole proving, and for several days after, 19.*
A slowly sticking pain beneath the sternum (after fifteen minutes), 13.
Intense burning pain between the breasts, most severe on the right side, in the afternoon (second day), 19.*
Burning sensation under the sternum, soon (eleventh day), 22b.*
A sickening sensation from the right breast downward to the stomach, causing qualmishness, as from Tart. emet., in the afternoon (second day), 19. [430.]
Pain in the right side of chest and hypochondriac region is very severe (second day); almost as severe (third day), 22a.*
Sharp piercing pain, midway between the sternum and right nipple, myalgic in character, and the surface feels tender on pressure (after forty-five minutes), 19.*
Hot burning streaming in the right side of the chest, commencing below the right arm and clavicle, and extending down to the hepatic region, at 4 P.M . (third day), 15.*
Acute stitches in the right side of the chest, near the nipple, .*

HEART AND PULSE. [460.]

Pressive pain beneath the præcordial region, 10.
Palpitation of the heart, 7.
Pulse increased eight beats per minute (first day), 22a.
Pulse accelerated by small doses, 17.
Rapid pulse, 10.
Pulse very quick, without much fulness (after fifteen minutes), 2.
Pulse feeble and quick; very easily compressed (third morning), 19.
Pulse 60 (eighth and ninth days), 22.
Pulse 72 (before the proving); 86 (after three hours, second day); feeble and quick in morning; 95 at 2 P.M.; 65, and easily compressed, at 10 P.M. (third day); 75 (fourth day), 19.
Pulse 58 (before the experiment); 62 (after twenty minutes), 2a. [470.]
Pulse 74 (before the experiment); 75 (after five and ten minutes); 76 (after fifteen minutes); 77, a little fuller (after twenty minutes); 77 (after twenty-five minutes); 76 (after thirty minutes); 75 (after thirty-five minutes); 77 (after forty minutes); 75 (after forty-five minutes); 74 (after fifty and fifty-five minutes); 73 (after sixty minutes); 74 (after sixty-five and seventy minutes), 1b.
Pulse 78 (before the experiment); same (after five and ten minutes); 80 (after fifteen minutes); 81 (after twenty minutes); 80 (after twenty-five minutes); 83 (after thirty and thirty-five minutes); 82 (after forty minutes); 80 (after forty-five and fifty minutes); 78 (after fifty-five minutes); 82 (after sixty minutes), 4.
Pulse irregular (twelfth day), 22b.
Pulse 76 (before the experiment); same (after five minutes); 78, full and strong (after ten minutes); 80 (after fifteen minutes); 84 (after twenty minutes); 86, very irregular and not so full (after twenty-five minutes); 86 (after thirty minutes); 87 (after thirty-five minutes); 84 (after forty minutes); 82 (after forty-five minutes); 85, extremely irregular in fulness and force, from the nausea (after fifty minutes); 80 (after fifty-five minutes); 77 (after sixty minutes); 74 (after sixty-five minutes); 75 (after seventy minutes); 73 (after seventy-five minutes); 72 (after eighty minutes); 73 (after eighty-five minutes); 74 (after ninety minutes), 1.
Pulse 76 (before the experiment); same (after fifteen minutes); 78 (after twenty minutes); 80 (after twenty-five minutes); 82 (after thirty minutes); 83 (after thirty-five minutes); 84, small and quick (after forty minutes); 80 (after forty-five minutes); 78 (after fifty minutes); 76, somewhat fuller (after fifty-five minutes); 75 (after sixty minutes); 74 (after sixty-five and seventy minutes); 73 (after seventy-five minutes); 77 nearly natural (after eighty minutes); 76 (after eighty-five minutes), .

NECK AND BACK

Stiffness of the nape of the neck, 10.
Rheumatic pains in the nape of the neck, shoulders, and arms, 10.*
Pain in the nape of the neck, 10.
Sore pain in the nape of the neck when touched, 10.
Pain in the right side of the neck, as if strained, 12.
Pain in the left side of the nape of the neck, 10. [490.]
In the night, severe backache between the crests of the iliac bones (fifteenth day), 20.
Pain down the back, and very severe in the lumbar region, and then down the extremities to the feet (third day), 19.
Soreness down the muscles of the back; feels it more when he draws his breath, pain shifts about (Fincke, 10m), 21.
Stitches from the back, beneath the left shoulder-blade, towards the shoulder-blade, worse than the stitches in the spleen (second day), 20.
Pain through the loins (third morning), 19.
Quite severe pain in the loins and down the extremities, in the morning (fourth day), 19.
Pain in the sacrum and bowels, 10.

EXTREMITIES

Convulsive rigidity of the limbs, 7.
Tetanic rigidity of the limbs and even of the whole body, 7a.
Stiffness of the limbs and rheumatic pains, with headache, 10.
Rheumatic pains in the limbs, 10. [500.]
Burning in the soles of the feet and palms of the hands, 10.
Violent pain in the right hand, so that the whole arm was sore, though lying quietly and warm in bed; also felt in the left foot several times, only on the top of the foot, afterwards in the heel and toes, 11.
Pain in the extremities (third morning), 19.

SUPERIOR EXTREMITIES

Shoulder.
Pain in both shoulders, 10.
Pain in the top of the right shoulder, 15.
Rheumatic pain in the right shoulder , worse in the morning, as if she had been lying in one position, extending down to the elbow, 14.*
Violent pain in the left shoulder, in the evening, 10.
Violent pain in the shoulder-joint, on every motion, 10.
Sudden rheumatic pain in the shoulder-joint, 10. [510.]
Pain along the inner border of the right shoulder-blade, with heat and chills alternating, and extending down to the kidneys, where there is great heat and pain (after three hours, second day), 19.
Quite severe pain in the right shoulder, and down the shoulder-blade, in the morning (fourth day), 19.
Arm.
Rheumatic pain in the arm and hand, 10.
Rheumatic pain in the right forearm, in the evening, 10.
Hand.
Redness of the hands with violent burning, 10.
Violent ulcerative pain in the palm of the right hand close to the index finger, 10.
Quite severe pain still continues in the right hand, in the morning (fourth day), 19.
Burning in the palm of the hand, 10.
Fingers.
Dull pain in the ball of the right thumb, 10.
Ulcerative pain in the root of the nail of the right thumb, afterwards in the left, then extending to all the fingers, one after another, from the thumb to the little finger, alike in both hands, 10. [520.]
Rheumatic pain in the right ring finger, just above the second joint, 10.
Cutting in the second joint of the left middle finger, 10.
Stitches in the tip of the right little finger, 10.

INFERIOR EXTREMITIES

Great weakness of the lower extremities and pain in the small of the back, relieved by bending forward (second day), 15.
Weakness of the lower extremities, while walking, 15.
Wandering rheumatic pains through both lower extremities, right most severe, in the afternoon (second day), 19.
Rheumatic pain in lower extremities (after three hours, second day), 19.
Severe rheumatic pain in lower extremities, and so severe in right ankle and toe-joint as to cause serious lameness in walking; some swelling in great toe-joint (after nine hours, second day), 19.
Hip.
Bruised pain in the left hip joint, only when walking, but worse when rising from a seat, 10.
Rheumatic pain in left hip, 10.
Knee. [530.]
Extremely weak in the knees and lower extremities, in the evening, while walking, 10.
Stiffness and tension in the hollows and sides of the knees (fourth day), 15.
Leg.
The left leg and foot swell, with inward burning and external coldness, at 4 P.M. (eighth day), 20.
In the evening the leg and foot swelled, with terrible burning pain; she did not know where to lay the limb; external coldness of the limb; the pain lasted until midnight; she had to nurse the limb continually; after midnight the pain became easier, but continued until next day (sixteenth day), 20.
In the morning a stitch from the middle of the right lower leg up through the knee-joint (second day), 20.
Drawing in the calves, extending into the heels, worse in the right, 15.
Cramp and crawling in the left calf (after fifteen minutes), 13.
Sharp pain in right ankle and also in great toe-joint (after three hours, second day), 19.
Ankle.
Constant sticking pain, as from a sting, below the right outer malleolus, 10.
Sticking pain in the right ankle, 10.
Foot. [540.]
Severe pain in the left foot, at the time as the pain in the left side of the head, .

GENERALITIES

Slight involuntary motion of muscles (after fifty-five minutes), 1c, 1d.
Slight tremors (after sixty minutes), 5.
Very restless all night (second night), 19.
Great debility (after forty minutes), 5. [550.]
Debility, with vertigo and pain in the hypochondria, 10.
Great weakness, 10.*
Very great prostration of strength, 7, 9, 18.
The prostrating effects of the drug compelled the suspension of all business, and I kept the bed during the fever, this afternoon (third day), 19.
General sensitiveness and weakness, 10.
Sensation of weariness and lassitude throughout the system (after one hour), 19.
With the pain at root of nose the same feeling of lassitude which induces me to retire early (after six hours), 19.
Feeling of weariness and lassitude pervading the whole system, in the afternoon (second day), 19.
Great lassitude and weakness, with the qualmish, sickening feeling (after three hours, second day), 19.
All the principal symptoms, including the great feeling of lassitude and weariness, increased; scarcely able to keep on my feet; the feeling of lassitude and restlessness continues to increase, and am able to attend to but little business (third day), 19. [560.]
Lassitude, and without ambition, in cloudy damp weather (second day); lassitude (third day); lassitude and sick feeling all day, as if she would have to lie down (eighth day); lassitude, in the morning (fifteenth day), 20.
Great languor, with an irresistible propensity to yawn (after fifty-five minutes); still continuing (after ninety minutes and subsequently), 6.
Extremely languid (after eighty minutes), 1c ; (after seventy-five minutes), 1d.
The dull languid feeling remained for some days after the proving, 22a.
Feel very languid from the fever, this afternoon; scarcely above to sit up, in the evening (third day), 19.
Very languid (eighth morning), 22b.
(eighth morning), .*

SKIN

Ulcer about the nail, 10.
Increased itching of an old tubercle-like eruption on the skin, 10.

SLEEP

Very frequent yawning (after sixty minutes), 5.
Yawning, with disposition to lie down (after one hour), 19.
Disposition to yawn and take deep inspirations, which cause intense tearing pain in right breast, in the afternoon (second day), 19.
Drowsiness coming on gradually, causing an indisposition to move, or to make any mental exertion (after forty-five minutes), 19.
Very sleepy, it is almost impossible to keep awake, while reading (eighth day); the drowsiness continues; did not wake at the usual time in the morning (ninth day), 22. [600.]
The demand for more sleep seems more urgent this morning than before; I yielded to the desire, sleeping an hour more than usual, but the inclination to "sleep on" remained the same (ninth day), 22.
The drowsy sleepy feeling is terrible; it seems impossible to get sleep enough (thirteenth and fourteenth days), 22.
One of the most prominent symptoms has been a sleepy feeling, and this remained until all the other symptoms of the drug had passed away, 22a.
Very sleepy, could not keep awake ten minutes, while reading (eighth day), 22b.
Starting from sleep, caused by a jerk through the whole body, several times (fourth day); restless sleep (sixth day); little sleep, many busy unpleasant dreams (seventh day), 20.
Passed a very restless night till towards morning perspiration broke forth freely, when most of the severe pains abated (third night), 19.
Woke earlier than usual, 15.
Woke at night, in fright, as if falling, 10.
Night sleepless, 10.
Dreams.
Dreams of a frightful and disagreeable character, 10. [610.]
Many dreams of business matters, in which she was the main person concerned (second day); restless sleep, with dreams of business matters (fourth day); many dreams of occupation, with anxiousness (seventh day), 20.
Troublesome dreams and restless tossing all night, with painful sighing respiration, and considerable dyspnœa (first night), 19.
Dreamed of a sea-voyage two nights in succession, although he had never been at sea, 10.
Dreamed of a dead body, which he helped to dissect, .

FEVER

Chilliness.
Chilliness in the evening, in bed, and shivering in the back, as if he had gooseflesh, 10.
Chilliness, with shaking and pain beneath the scapulæ, on motion, 10.
Chill and nausea, 10.
Chill, with the headache, 10.
Light chills at 2 P.M., followed by hot flashes; pulse 95, for fifteen or twenty minutes, when burning fever set in, with exacerbation of all the symptoms; fever subsiding and pains abating, at 10 P.M. (third day), 19.
Coldness, 7. [620.]
Coldness of the surface, more particularly of the extremities, 7a.
Cold and moist skin, with feeling of inward heat (seventh day), 20.
Wrists cold and a profuse sweat on my forehead (after thirty minutes), 1c.
Heat.
Febrile condition came on at 2.30 P.M., not as severe as the day previous, and passed off between 8 and 9 P.M. (fourth day); the fever recurred four or five days, gradually subsiding, yet very regularly between 2 and 3 P.M., 19.
Very feverish state of the system (third morning), 19.
Slight flushes of heat, followed by chills (after three hours); and in less than an hour face flushed, with fever; hands hot (second day), 19.
Great increase of heat through the right shoulder and clavicle to the right breast, extending to the stomach and bowels (after three hours, second day), 19.
Burning heat, suddenly alternating with chilliness and shivering, at short intervals, 11.*
Heat flying from the head to the stomach, 10.*
Feels suddenly warm, it lasts only a few minutes (Fincke, 10m), 21.* [630.]
Glow of warmth over my body (after thirty-five minutes), 1c.*
Sweat.
Perspired freely (after fifty minutes), 1c.
Cold sweat, 7a ; (fifth day), 20.

CONDITIONS

Aggravation.
( Morning ), After cold drinks, pain in right lower molar; after waking up, dry and raw sensation on tongue; pain in shoulder; in bed, stitches in heels; most symptoms.
( Afternoon ), Dimness of eyes.
( Evening ), Headache; tickling in throat, with cough; after lying down, hacking cough; pain in left shoulder; pain in right forearm; while walking, weakness in knees and lower extremities; most symptoms.
( Night ), Colic, with pain in small of back; frequent micturition; burning in soles of feet.
( Hot drinks ), Toothache.
( While eating ), Hacking cough.
( After eating ), Sweet things, burning in fauces; nausea.
( Exercise ), Frontal headache.
( Deep inspiration ), Soreness in chest; constriction across breasts.
( While lying down ), Headache, with vertigo and earache.
( Motion ), Headache; pain in shoulder-joint.
( On moving and turning body ), Stitches in left side.
( A long ride ), The symptoms.
( Rising from a seat ), Vertigo; frontal headache; pain in left hip-joint.
( Rising quickly from stooping ), Vertigo and faintness.
( On smoking ), Hiccough.
( While standing still ), Pain in right side of forehead.
( Stooping ), Headache; nausea; pain in epigastrium.
( Swallowing ), Pain in throat.
( During and after touch ), Pain in beneath right nipple.
( Touch of food ), Pain in a hollow tooth.
( Touch ), Pain in nape of neck.
( Turning head quickly ), Vertigo and faintness.

Sanguinaria