Spurred rye; Ergot of rye.

The fungus Claviceps purpurea , Tulasne, is the cause of this disease in rye (and in other grasses), see Lolium. Moisture favors the development of this fungus; epidemics, known as Raphania, Kriebelkrankheit, etc., are traced to the use of rye flour poisoned by this fungus.

Preparation for use, Tincture.

Authorities. (Nos.

1 to 80 , from Trink's collection, Hartlaub and Trinks, Annalen der Hom. Klinik, 3, 228).

1 , Caspar Schwenkfeld, Theriotrophæum Silesiacum, Lignit, 1604, giebt die erste Nachricht von dem Vorkornum der Kriebelkrankheit; 2 , Barbeck, de morbis convulsis. Duisb., 1763, 4; 3 , Perrault, Lettre de Dodart in Journ. des Savans, ann. 1676, T. IV, p. 79; 4 , Thulier, in Journ. des Savans, ann. 1676, T. IV, p. 79; 5 , May, Bericht, wie die sich ereigwende Grimmund Krampfsucht zu kuriren. Kassel, 1683, 4; 6 , Fr. Hoffman, med. rat. system, T. II, p. 300; 7 , Geoffroy, Tractatus de Mater. med. Venet., 1665, T. II, p. 2; 8 , Wepfer, Eph. Nat. Cur. Dec., III, Ann. II, p. 300; 9 , J. Scheuchzer, Miscell. Lips, T. V; 10 , J. H. Hoffmayer, Sendschreiben von der bisher an vielen Personen in seiner Gegend gefundenen Kiebelkrankheit, krummen, oder schweren Nothkrankheit, deren Ursachen und Heilmitteln, Berlin, 1702, 8; 11 , Mémoires de l'Académie de Paris, 1710; 12 , Lang, descriptio morborum ex clavorum secalinorum usu, etc., Lucern, 1717, 8; 13 , W. H. Waldschmidt, de morbo epidemico, per Holsatium grassante, Kilon, 1717, 8; 14 , Haberkorn, unvorgreifliche Gedanken von der Ziehe--oder Nervenkrankheit, welche durch das inficirte Korn in Sachsen und der Lansitz eingerissen, Budissin, 1717, 8; 15 , G. Budæi., consilium medicum von d Krampfkrankheit, Budissin, 1717, 8; 16 , G. W. Wedel, de morbo spasmod. epidem. maligno in Saxonia, Lusatia, etc., Jenæ, 1717, 4; 17 , J. D. Longolii, judicum medicum de corruptione lymphæ per frumentum corruptum, oder medic. Gedanken von der Kronstaupe, welche ann., 1716-17, an verschiedenen Orten in Sachsen unter dem Titel des Reissens und der Ziehkrankheit, etc., bekannt. S. k., 1717, 8; 18 , C. G. Wilisch, Bericht von der Krampfsucht, oder spasmod. Krankheit, so an verscheid. Orten im vergang. Jahre sich ereignet., Pirna, 1718; 19 , Breslauer Sammlung von Natur-, Medicin-, Kunst- und Literatur-geschichte, I, II, Vers., 1718; 20 , G. Schober, epitome diss. med. de sem. loliac. et secalis nigri corrupt., cum farina commixt. et alimenti loco assumtis varios morb. epid. ann. 1722, etc., producent. in Act. Cand. Lips., 1723; 21 , C. Vater, observationes selectæ de morbo spasmod. popillari Silesiaco. Viteberg. 1723; 22 , Noel, in Histoire de l'Acad. des Scienc. ann. 1710, page 80; 23 , Fontenelle, in Histoire de l'Acad. des Scienc. ann. 1710, p. 81; 24 , H. Ludolf, diss. sistens casum novi morbi spasm. convuls. vulgo dicti: Steifenfuss, steife Krankheit, Krampfsucht, ziehende Seuche, Grübelkrankheit, Erford, 1727, 4; 25 , ---, diss. de affectu spasm. vago maligno epidem. vernac. Grübelkrankheit, Erford, 1756, 4; 26 , F. E. Brüchmann, relatio de clavis secal. morbor. inde exort. epidem., quem die Kriebelkrankheit vocant, etc., in Comment. lit. Novimb., 1734, heb. VII, Nr. III; 27 , C. A. Bergen, dissert. de morbo epidem. convulsivo, contagii experte. Francofurt. ad Viadr., 1742, 4, auch in Haller, Samml. prakt. Streitschriften, B. I, p. 87; 28 , Rosén a Rosenstein, diss. de morbo spasmod. convulsivo epidem. Goth, 1749, 4; 29 , Cothenius, Nachricht von der Schädlickheit des Mutterkornes in Schreber's Samml. verschied. Schriften. halle, 1756, 8, Th. II, p. 413; 30 , P. J. Bergic, diss. de epilepsia acuta epidemica, Holm, 1756, Mater. Med. e regno veget. T. I., p. 49, obs. VI; 31 , Tissot, epistola ad D. G. Baker, de morbis ex usu secalis cornuti, data Lausannæ, 1764, anmehren Orten in's Deutsche uebersetzt; 32 , Müller, in Act. med. Berol. Dec., II, vol. vi, p. 50; 33 , Burkhardt, in Satyr. med. Siles. Spec., III, Obs. IV; 34 , Ant. Scrinc, in Satyr. med. Siles. Spec., IV, Obs. V, p. 35; 35 , Salerne, Mémoire sur les maladies que cause le seigle ergoté in d. Mém. de Math. et de Phys. de l'Acad., T. II, p. 155; 36 , Dodart, im Journal des Savans, 1769, ch. 16, Mars.; 37 , Linné, Diss. de Raphania, Upsal., 1763, 4; 38 , Sauvages, Nosol. Method. Amstelod., 1763, T. III, P. I, p. 547; 39 , Th. Aug. Schleger, Versuche mit d. Mutterkorne, Cassel, 1770, 4; 40 , M. Vetillart, Mémoire sur une espèce de poison sous le nom d'argot, seigle, ergotés, blé cornu, mane, etc., Tours, 1778; 41 , Du Bourrix, Mémoire sur la nature et les effets du seigle ergoté, pour servis de réfutation au mémoire de M. Schleger, Paris, 1771; 42 , Wichmann, Beiträge zur Geschichte der Kriebelkrankheit im J., 1770, Leipz. u. Zelle, 1771, 8; 43 , Vogel, Schutzschrift für das Mutterkorn, als einer angelblichen Ursache der Kriebelkrankheit, Götting., 1771, 8; 44 , Leidenfrost, diss. de morbo convuls. epidem. Germanorem, caritatis annonæ comite, vulgo; die Kriebelkrankheit, Duisburg, 1771, 4, und in Baldinger's Magazin, 1776, St. IV; 45 , L. E. Eschenbach, Bedenken vor der Schädlichkeit des Mutterkornes, Rostock, 1771, 8; 46 , Baldinger, Programma ad diss. de metastasi in morbis, præfatio docet, secale cornutum perperama nonnullis ab infamia liberari, Jenæ, 1771, 4; 47 , Taube, Geschichte der Kriebelkrankheit, besonders derjenigen, welche in d. Jahren, 1770, u. 71, in den Zellischen Gegenden gewüthet hat. Gott., 1782, 8; 48 , Marcard, von einer der Kriebelkrankheit ahnlichen Krampfsucht, die in Stade beobachtet ist., Hamburg, 1772, 8; 49 , Focken, Versuche, Beobachtungen, Erfahrungen und Kurarten in d. sogenannten Kriebelsucht, Zelle, 1771, 8; 50 , C. L. Nebel, diss. de Secale cornuto, ejusque noxa, experientia atque experimentis chemic. nixa., Giess, 1771, 4; 51 , Ejusdem Progr. quo diss. suam de Secali cornuto a noxiis ac temerariis et contumeliosis objectionibus Schlegeri vindicat, Giess, 1772, 4; 52 , B. W. Roeder, gründliche Abhandlung von der in Deutschland hin und wieder grassirenden Seuche, die Kriebelkrankheit oder Krampfsucht genannt, worin deren Beschaffenheit, Ursachen, Vorbauung und Heilung beschrieben, Frankf. und Leipzig, 1772, 8; 53 , J. L. Herrmann, Abhandl. u. gegründ. Wahrnehm. von der Kriebelkrankheit, so in Niederschlesien, 1771, u. 72, epidem. grassirt hat, Kassel, 1774, 8; 54 , Read, Traité sur le seigle ergoté, Strasbourg, 1771, 12; 55 , Tessier, Traité de maladies des grains, Paris, 1783, 8; 56 , ---, Mémoire sur les observat. faites en Sologne en 1772, in Mém. de la soc. roy. de Méd., A. 1776, p. 417; 57 , Sangiorgio, diss. sur la gramigna che nella Lombardo infesta la segala, Milan, 1772; 58 , C. L. E. Hartmann, Berichte und Bedenken, die Kriebelkrankheit betreffend, etc., Kopenhag., 1772; 59 , Berichte und Bedenken, welche von den schleswigholstein, Physicis and d. kön. d. Kammer zu Kopenhagen sind gesandt worden, nebst d. Respons. des k. Coll. med., und ein Unterricht für d. Landvolk, Kopenhag., 1774, 8; 60 , G. M. Brawe, Beiträge zur Geschichte der Kriebelkrankheit im Jahre 1771, Bremen, 1772; 61 , Dreyssig, Handbuch d. med. Diagnost. Bd., 2; 62 , Haase, Handbuch der chron. Krankheiten, T. II; 63 , Jahn, Klinik d. chron. Krankheiten, T. I, p. 253; 64 , Richter, Spec. Therap., T. IV; 65 , Haller, Mat. med, übers. von Vicat. T. II; 66 , Spielmann, Institut. mat. med.; 67 , Keyl, Diss. de Secali corn. ejusque vi in corp. human. salubri et noxia, Berolin, 1823, 8; 68 , C. Knape, über die zweckmäss. Schutzmittel gegen d. nachtheil. Wirk. des Mutterkornes, in Hecker's Jahrb. d. St. A. I. B. 2, Th. p. 240; 69 , J. C. Lorinser, Versuche u. Beobacht. üb. die Wirk. des Mutterkornes auf d. menschl. u. thier. Körper, Berlin, 1824, 8; 70 , Henning; 71 , Waghas; 72 , Nolten; 73 , Class; 74 , Evers Taube; 75 , Œltze; 76 , Osswald; 77 , Roemhild bei Lorinser; 78 , Cordier bei Froriep; 79 , Uensler; 80 , Acta Eruditor; 81 , Bigelow, N. E. Med. J., 1816, p. 162, effects in seven cases, from doses of over a scruple; 82 , Wessener, Hufel. J., 1817, effects of eating rye bread poisoned with it; 83 , Villeneuve, A. H. Z., 1, 131, Histoire sur Secale Cornut., Paris, 1827, general effects; 84 , Hartmann, A. H. Z., 1, 27, symptoms; 85 , Perrotton, Hirschel's Archiv, 1, 156, effects of large doses, in labor; 86 , Puchstein, Hirschel's Archiv, 1, 235, effects of "ergot bread;" 87 , same, in a man; 88 , Lorenz, A. H. Z., 1, 131, general effects; 89 , Wagner, A. H. Z., 1, 129, from Hufel. J., 1832, epidemic poisoning; 90 , Swett, Bost. M. and S. J., 1834, p. 420, general effects; 91 , Munsell, Lond. Med. Gaz., 14, 605, a woman in fourth month of pregnancy took a drachm; 92 , same, another woman took a drachm in two doses; 93 , same, a woman in labor took 2 drachms in two doses; 94 , Hooker, Bost. M. and S. J., 10, 299, a man took 1/2 drachm of the light oil at 2 P.M., and 1 drachm at 3 and 4 P.M., also another man experienced the same effects from 40 minims; 95 , same cases, the symptoms that continued apparent for a week; 96 , same, a man took 14 ounces of infusion, and another man 8 ounces within two hours; 97 , Hulse, N. A. Archives of Med. and Surg. Sc., 1835, p. 81, a woman, just delivered, suffering from hæmorrhage, took 12 ounces of infusion in doses, every half hour; 98 , Jacoby, Archiv. de Méd. Strasbourg, 1835, effects of drachm doses of powder during pregnancy; 99 , Thompson, Lancet, 1836-7, p. 854, effects; 100 , Schramm, Berlin Kl. Wach., 1837, p. 378 (from Helbig Heraclides, 1, 56); 101 , Roullin, Froriep, Notizen, 1829 (from Helbig); 102 , Jansen, Rust's Mag., 1829 (ibid.); 103 , Cottmann, Am. Med. Intell., 3, 329, experiments on healthy lunatics, with scruple and 1/2-drachm doses; 104 , Beckwith, Am. Med. Intell., 3, 213, a woman in labor took 30 grains; 105 , Allier, Bull. de Thérap. (Am. J. of Med. Sc., 25, 210), effects in cases suffering from paralysis of the bladder; 106 , Ann. de Méd., 1, 839, effects in a healthy man, of 24 grains; 107 , Chavasse, Transact. Prov. M. and S. Assoc., 4, injurious effects; 108 , De Gravina, Annali Univers di Med., 1839 (Br. and F. Med.-Chir. Rev., 1840), the author took 24 grains; 109 , Jablanczy, A. H. Z., 30, 295, provings on self, with a dose of 50 drops of tincture; 110 , same, on Mr. Matzeka; 111 , Maisonneuve, Gaz. des Hôp., 18, 711; 112 , Barbier, Recherches sur Secale (A. H. Z., 20, 143), a person took several drachms; 113 , Wright, Edin. M. and S. J., 1840, p. 9, effects of a dose of 2 1/2 drachms; 114 , same, a woman, flooding, took 1/2 drachm three times a day for a fortnight, then 1 drachm four or five times a day for five days; 115 , same, a woman in labor, took an infusion of 2 drachms; 116 , Holt, Lancet, 1842-3, 1, 712, effects on infant, when administered to mother during labor; 117 , Cotlet, Edin. M. and S. J., 1842, 1, 83, effects of 1/2 drachm, repeated in twenty minutes, in a woman in labor; 118 , Med. Times, 1843, 419, effects of 3 drachms, in a woman with cancer of neck of uterus; 119 , Bost. M. and S. J., 1843, 168, from Gaz. des Hôp. dysentery in twenty-seven persons, caused by eating diseased rye; 120 , Gibbon, Am. J. of Med. Sc., 33, p. 244, 1844, a healthy man took 16 grains of powder in a decoction; 120 a , same, took a scruple in a decoction; 120 b , same, 1 drachm; 121 , Gibbons, took aq. ext., 10 grains; 121 a , same, took 30 drops of the ethereal oil; 122 , Parola, Gaz. Med., 1844, No. 19, effects of 30 grains (symptoms after two hours); 123 , same, experiment on self with 20 grains; 124 , Patze, Med. Zeit. Preuss., 1844 (Br. J. of Hom., 3), effects of a drachm of powder; 125 , Pardu, Annali Univers di Med., 1844, effects of 30 grains, in a man suffering from a trifling disorder; 125 a , same, repeated with same and additional symptoms; 126 , same, another in health took 20 grains of powder; 126 a , same, took 30 grains, after a hearty meal; 127 , Med. Zeit. Preuss., 1845, a man took a drachm of powder; 127 a , same, repeated; 127 b , same, 2 drachms; 128 , same, another man took a drachm; 128 a , same, repeated; 128 b , same, took 2 drachms; 129 , Ker, Br. J. of Hom., 8, 462, effects; 130 , Arnal, Mem. Royal. Acad. de Méd., 1849, experiment on self, took 1 1/2 drachms of powder, kept quiet, and counted his pulse every fifteen minutes; 130 a , same, another experiment; 131 , Nuttal, Med. Times, vol. 16, p. 391, effects of eating poisoned bread; 132 , Œst. Med. Woch., 1847, No. 42, effects of poisoned bread; 133 , Bonjean, Lancet, 1845, 1, 701, a family poisoned by bread; 134 , Pratschke, Casp. Woch. (Lond. Med. Gaz., 1850, p. 579), poisoning of a woman by bread; 135 , same, a girl aged eighteen; 136 , same, a girl aged seven; 137 , same, child aged four; 138 , Ungefug and Strahler, Zeit. Verein Œst., 2, 252, ergotismus, in a boy; 139 , same, in a man; 140 , Huss-busch, Frank's Mag., 4, 687, cases of ergotismus; 141 , same, effects of a teaspoonful taken to produce abortion; 142 , Hussa, Vjs. Prag., 1856 (A. H. Z., 52, 167), poisoning of three persons by flour, one sixth ergot; 143 , same, in a boy; 144 , same, in a girl; 145 , Heusinger, Deutsch Klin., 1856, epidemic ergotismus; 146 , Zabari, Œst. Zeit. f. ver. Ærzte, 1, 117, effects of poisonous bread, in a child; 147 , same, in a woman; 148 , Dietz, Zeit. f. ver. Ærtze Œst., 2, 252, effects of 2 drachms; 149 , Channing, Bost. M. and S. J., 1859, p. 138, effects of quarter of a pound, in a pregnant woman; 150 , Meyer, Wien Wochbl., 1861, epidemic of ergotismus; 151 , Neubert, Journ. of Pharmacod., 2, 4, a woman poisoned; 152 , Ricker, Nass. Med. Jahrb., 15, 748, a family poisoned by bread; 153 , Casp. Vjs., 20, 1862, effects of large doses, in a woman; 154 , Poyet, Annal. de Soc. de Méd. de St. Étienne et de la Loire, 1863, effects of ergoted bread; 155 , Hill, Trans. N. Y. Hom. Med. Soc., 2, 214, effects of 1/2 an ounce of powder, in a woman suffering from continued menstruation, death on eleventh day; 156 , same, from N. O. Journ. of Med., a woman six months pregnant took powder of ergot, 40 grains every half hour, for about two hours; 156 a , same case, two days later, took 3/4 of an ounce in six hours; 157 , Stephens, Brit. Med. Journ., 1864, p. 503, fatal effects of tincture, taken to produce abortion; 158 and 159 , omitted; 160 , Flinzer, Vjs. f. ger. Med., 8 (1869), a boy poisoned by bread; 161 , same, another boy; 162 , a girl, aged sixteen; 163 , same, a woman; 164 , same, a girl, aged twenty-two; 165 , Possart, Am. Obs., 6, 21, effects of poisonous doses; 166 , Dr. G. S. Oldright, Canada Med. Journ., 6, 404, effects of ergot administered three days after delivery for slight flooding; 167 , Nicol, Br. and F. Med.-Chir. Rev., 1872, 2, 203, effects of drachm and 1/2-drachm doses of fluid extract; 168 , Heuschel, Med. Rec., 9, 471, an infant, born about the eighth month, received by mistake, 30 drops of Squibb's fluid extract; 169 , Wernich, Einige Versuche ueber das Mutterkorn, Berlin, 1874, effects of a large amount, in a woman three months pregnant; 170 , Smith. Pharm J., 1874, p. 622, effects of 3 to 7-grain doses.

MIND

Delirium, 20, 91, 161.*
Delirium; she abandons her relatives and does absurd things, 42.
Delirium; he makes no answer (in a child eight years old), 42.
Muttering delirium, very restless, agitated, and fearful of death (first day), 155.
Muttering delirium (in six hours), 93.
Delirium with violence, 37.
Confusion of mind, with delirium bordering on mania; every patient raved and could be restrained only with great difficulty; followed after some hours by violent involuntary vomiting, and by continued deep sleep; after this there remained excessive vertigo, as after intoxication, with a feeling of exhaustion and powerlessness, 72.
Rage, 165.
Raving, 32, 34 , etc. [10.]
Raving, with an attempt to jump into the water, 71.
Raving, so that she must be restrained, 73.
In two hours delirium came on, succeeded by heavy sleep and snoring. She could be roused, not to consciousness, but to low muttering, wanderings, 104.
Extreme excitement, with wild look and impaired vision, 98.
Excited and confused, 166.
Transient delirium with the headache (second and third days), 156a.
Slight attacks of delirium, 64.
Mild delirium, 64.
A considerable degree of exhilaration, with preternatural wakefulness, both of them lying awake, with a very pleasant train of sensations and thoughts, through nearly the whole succeeding night, 96.
Sensorium disturbed in the night; could not get rid of the impression that there were two sick persons in the bed, one of whom recovered and the other did not (fifth night), 155. [20.]
She was conscious, but the room presented to her the impression of water excessively agitated on its surface. She could compare it only to the "foaming of a troubled sea," 115.
Illusions of sense, 62, 145.
Imbecility, 165.
Mind weak for a long time, 47.
Foolishness, 32.
Those usually sad become jolly and even foolish, 89.
Cheerful and constant joyous mood, 109.
Strong desire to recover (eighth day), 155.
Constant moaning and fear of death , with strong desire to live (eleventh day), 155.*
Constant moaning and swaying of the arms to and from the head (first day), 155. [30.]
Moaning, sighing (tenth day), 155.
Extreme sadness, 64 ; (after one hour), 126a.
Sad mood, 84, 89.
Loathing of life; despair (tenth day), 155.
Desire to be left undisturbed (first day), 155.
Great depression, 125.
The greatest depression of mind and loss of strength, a very sick feeling, 61.
Depression of spirits, 64.
Constant despondency and fearfulness, 61.
Increased despondency, 64. [40.]
*Anxiety, 70, 125, 134, 138, 160.
*Great anxiety, 71, 84.
*Frightful anxiety, 63.
Anxiety and difficult respiration, 48.*
Anxiety, obstinacy (tenth day), 155.
*Anxiety and fear of death (tenth day), 135.
Melancholia, 34.
Hypochondria; patient says she must have something to relieve her or she must die (ninth day), 155.
Excessively nervous and irritable, 114.
Obstinacy, in a boy eight years old, 42. [50.]
Indifference to everything, 64.
Disinclination for work, 84.
Disinclined to answer, 153.
Great weakness of thought, 84.
Thought disturbed, 70.
Thought and speech difficult, 70.
Intellectual languor (after three hours), 126.
The only expression that he gave utterance to was a stupid kind of "I am hungry," 87.
Forgetful, weak-minded, 61.
Weakness of memory (first day), 153. [60.]
Memory lost, forgot what he had just said, 139.
Diminution and loss of the senses, sight, hearing, etc ., 64.*
All the senses benumbed, 47.*
Great dulness of sense, 70.
Gradually became insensible and died without struggling (eleventh day), 155.
*Consciousness seems to continue till the last breath, and just before death it seems as though the patient would improve, 64.
Apathy, 108.
Felt ill at ease, stupid, sleepy (after one hour), 126a.
Mind stupid, 33.
Stupor, with dilated pupils, 42. [70.]
Stupefaction, 12, 32, 64, 65, 74, 86.*
Stupor, 84, 92, 152.*
Chronic stupor, 62.
Complete loss of senses, 64.
Loss of consciousness, 143.
Incomplete coma (in six hours), 93.
Coma, 34.

HEAD

Confusion and Vertigo.
Confusion of the head, 64.
Confused feeling in the head, 170.
*Vertigo, 20, 64, 70, 71, 76 , etc. [80.]
Chronic vertigo, 142.
Vertigo and reeling, so that the patients could not stand upon their feet, 100.
Vertigo and reeling as if intoxicated, 100.
Vertigo for twenty-four hours after a dose, 84.
Reeling as from intoxication, 34.
Vertigo, that often lasts more than a month, sometimes disappearing for a short time, at other times more violent than ever, especially after eating bread, 72.
Constantly increasing vertigo, 34.
Vertigo, 74 . [Caused by the odor of the fungus in the meal.]
Vertigo (after half an hour), lasting twelve to twenty hours, and even obliging the patient to remain in bed several days, 75.
Vertigo and stupefaction, 61, 70. [90.]
Vertigo and heaviness of the head, 34.
Reeling, with inability to stand upright, 75.
Dizziness and weakness (after two hours), 166.
Dizziness of the head, on moving (sixth and seventh days), 135.
Head dizzy and heavy (ninth day), 155.
Dizziness and heaviness of head (tenth day), 155.
Giddiness and whirling of the head (tenth day), 155.
Could scarcely walk, owing to the giddiness which had succeeded to the confusion of the head (fourth day), 124.
Giddiness and sensation as if about to fall, on the slightest movement (first day), 155.
Intoxication, 22, 65, 75.
General Head. [100.]
Pendulum-like movements of the head, 147.
Pendulum-like movements of the head, from side to side, 146.
Head sometimes heavy and throbbing, and again so light and giddy that she could scarcely stand, 114.
Weight of head (after one hour), 126.
Uneasiness and heaviness in the head, 134.
Heaviness of the head (after one hour), 64, 123 ; (seventh day), 155.*
Head heavy and dizzy (eleventh day), 135.
Stupefaction of the head, 148.*
Congestion to the head, 98.
Great dulness of the head, 145. [110.]
Great dulness of the head and vertigo, so that they could not keep erect, and either fell to the ground or were obliged to hold to something, 72.
Great oppression in the head, with incapacity for any mental exertion, 108.
Dulness and stupefaction of the head, 35.
Dulness of the head, 47, 61, 84, 127, 128.*
Dull headache, 64.
Headache, 64, 70, 71 , etc.*
Violent headache, 91, 92, 99 , etc.
Excruciating pain in head, 157.
Left-sided headache, 84.
Burning headache, 140. [120.]
Slight headache, 113.
Pain in the head (first day); became intense, with transient delirium (second and third days), 156a.
Peculiar feeling of lightness of the head, particularly of the occiput (after a quarter of an hour); on the following morning, the confusion of the head continued, 124.
An agreeable sensation in the head (seven minutes after first two doses), followed by an unpleasant, heavy, confused feeling, particularly in the posterior part of the head, and a slight general exhilaration (after each dose), 94.
Head seemed perfectly empty, and the sense of hearing had become so heightened that every word spoken in the lowest tone reverberated through the head, and passed through every nerve of the whole body, 97.
Unpleasant sensation in the head, but no pain (fifth day), 155.
Head vacant, with feeling as if something whirled round in it (ninth day), 155.
Sharp pain in the head, with dizziness after the chill, relieved by the diarrhœa; the pain returned the next morning, after the diarrhœa had ceased, 156.
Throbbing in the head (sixth day), 155.
Biting sensation on the head, 89.
Forehead. [130.]
Violent burning pain in the frontal region, so that he would willingly die, with a sad expression, mouth drawn and constantly filled with saliva from the submaxillary glands, which were swollen, 100.
Burning pain in the frontal region, day and night, 100.
Throbbing frontal headache (after one hour), 126a.
Vertex.
Heaviness in the sinciput (after two hours), 130.
Occiput.
Dull headache in the occiput, 64.
Headache in the occipital region (ninth day), 155.
Severe pain in the back of the head (first day), 155.
Pressive pain in the occiput, 110.
Lightning-like pain in the occiput, extending down the nape of the neck, 146.
External Head.
The hair fell out, became dry and gray, 132. [140.]
Falling of the hair, 101.
Sensation as if the hair was pulled, 89.

EYE

After the epidemic an unusually large number of cataracts occurred in young people, twenty-three of whom gradually became blind (fifteen men and eight women), associated with headache, vertigo, and roaring in the ears; of the cataracts two were hard, twelve soft, and nine mixed, 150 . [Out of 283 persons attacked, 198 died.]
*Eyes sunken and surrounded with a blue margin (fifth day), 156.
*Eyes lay deep in the head (fourth day), 124.
Eyes staring and wild, with dilatation of pupils (second day), 135.
Eyes wild and distorted, with pupils much dilated (first and second days), 155.
*Staring look, 139.
Wild staring look; face red; inarticulate moans and movements of the head to and fro; arms rigid and immovable the hands drawn over to the chest, 87.
Eyes wild, distorted, 42. [150.]
Staring and blindness, 37.
Spasmodic distortion of the eyes, 63.
Fixedness of the eye (soon after second dose), 117.
Glistening eyes, 83.
Right disk decidedly paler, with retina also of a paler tint. Left also paler (in one hour). Right disk paler; on apparent inner side decidedly; on outer side also a little. Left eye altogether a little paler (in one hour and twenty minutes). Retina and disks of both eyes decidedly pale, and this is especially observable in the right eye (in one hour). Retinæ not quite so pale; disks the same as before (in one hour and a half), 167.
Eyes very yellow (sixth day), 155.
Rolling of the eyes about the orbits, 64.
Squinting, 64.
Light painful to the eyes (eleventh day), 155.
Pain in the eyes (first day), 156a.
Conjunctiva. [160.]
Conjunctiva and sclerotic coat yellow and injected (second day); conjunctiva bright yellow (fifth day), 155.
Ball.
Pressure in the eyeball, 84.
Pupil.
Remarkable dilatation of the pupils, in a boy eight years old, 42.
Remarkable dilatation of the pupils, 47.
Pupils much dilated, 131.
Dilatation of the pupils, during the remission, 61.
Dilatation of the pupils, 48, 86, 94, 95 , etc.*
Pupils somewhat dilated and rather sluggish, 157.
Slight dilatation of the pupils, 96.
Pupils greatly contracted, in a girl eight years old, 70. [170.]
Spasmodic contractions of the pupils, 64.
Pupils contracted, almost entirely closed, with frightful distortion of the eyes, 64.
Vision.
Weakness of vision, 143.
Slight impaired (fourth day), 124.
Dimness of vision, 142.*
Greatly diminished power of vision, 84.
Dimness and confusion of sight (after half an hour), soon followed by double vision and then entire blindness, 104.
Troubled vision (soon after second dose), 117.
Vision imperfect, at times almost total blindness (second and third days), 156a.
Partial blindness, after the chill, 156. [180.]
Eyes blurred, with dimness of vision (eleventh day), 155.
Dimness of vision, especially when rising or moving in bed (tenth day), 155.
Great darkness before the eyes, 48.
Objects seen double, 34.
Objects seen double and triple, 75.
Frequent double vision, 84.
Photophobia, 166.
Blindness, 34.
Amaurosis, 62.
Veil before the eyes, 61. [190.]
Everything looks black when moving the head (tenth day), 155.
When rising up in bed everything turns black before her eyes (seventh day), 155.
Sparks appeared to flash before her eyes, 114.
Frequent flashes of light in the eyes (after forty-five minutes), 94.
Flickering before the eyes, 63.
Mist and sparks before the eyes, 62.
Sees stars, 48.

EAR

Sensation as if the ears were stopped, 110.
Roaring in the ears, with great difficulty of hearing, 61.*
Roaring in the ears, 62, 84, 145.* [200.]
Difficulty of hearing, 70, 84.
Hearing impaired (fourth day), 124.
Transient deafness with insensibility of the fingers of the whole hand; frequent falling asleep of the limbs, 48.
Deafness (soon after second dose), 117.*

NOSE

*Constant nosebleed, 12.
*Nosebleed, 28, 64 ; (fourth day), 124 ; (eleventh day), 135.
Hæmorrhage from the nose (third day); worse than before (fourth day); epistaxis (fifth day), 155.*
Dryness of the nasal mucous membrane, 139.
Olfactory nerves very sensitive (tenth day), 155.

FACE

Shortly the palpebræ began to swell, likewise the lips and fauces; the tears flowed copiously; the Schneiderian membrane seemed much stimulated, and there was coryza, great difficulty of breathing through the nose, and injection of the vessels of the conjunctiva. The lips and palpebræ began to puff, as if stung by a bee, and gradually assumed a livid appearance. The power of deglutition was nearly lost; the voice became feeble; she said her jaws were fixed, and shortly after it was with greatest difficulty that an answer of yes or no could be elicited. Previous to arriving at this point, she had complained of pain in every nerve, and a sensation of emptiness of the head, 97. [210.]
The face and head suddenly became intensely congested, being of a purplish-red color, after stimulants and warmth were applied, 166.
Face and abdomen swollen, 32.
Face puffy, 98.
Face sunken, often discolored, 47.
*Features sunken, 64.
*Face drawn, 142.
Risus sardonicus, 165.*
Suffering expression, 48.
Face hippocratic, discolored, 61.
Stupidity of expression (soon after second dose), 117. [220.]
Countenance had a remarkably heavy idiotic expression (after second dose), 94.
*Expression of face most anxious, 157.
Face pale and haggard, 138.
*Face pale and collapsed (next morning); ashy (fourth day), 124.
*Face pale, 122, 125, 151, 153.
*Face very pale, 108.
*Face pale, sunken, hippocratic, 64.
Transitory paleness (in one hour), 167.
Face flushed and livid at times (first day), 156.
Flushing of the face, 99. [230.]
Faces warm and red, 127b, 128b.
Redness of the face, 83.
Face red, with thirst and some delirium, in children, 76.
Face dark red, 64.
Face yellow, 35.
Face yellowish, sunken, and distorted, 47.
Livid face (in six hours), 93.
Countenance generally more livid at birth, 116.
Cheeks pale (after three-quarters of an hour), 106.
The lips were retracted so as to expose the teeth, 135. [240.]
Lips bluish, 116.*
Distortion of the mouth, 37.
Trismus, 61, 64.

MOUTH

Teeth.
Gnashing of the teeth, 64.
The teeth became loose and fell out, 101.
Bloody sordes (tenth day), 155.
Sordes on the teeth (seventh, eighth, and ninth days), 135.
Toothache, to which he had been subject, on exposure to cold (after one hour), 126a.
Tongue.
The patient frequently bites the tongue, 61.
The tongue is often torn during the most violent convulsions, 34. [250.]
Tongue a good deal swollen (second day), 104.
Twitching and swelling of the tongue, with a suffocated voice and a constant flow of saliva, 34.
Tongue heavy, tremulous, white, difficult to protrude between the teeth, so that speech was almost unintelligible, 100.
Tongue dry, scarlet at the edges, crimson and black in the middle (second and third days), 156a.
Tongue white, 138.*
Tongue white and moist, 135.
Tongue heavily coated white at noon, dry and brown at the tip (first day); coated with a heavy brown fur and pointed at the end (second day); heavily coated with a brownish fur, dry at the tip, edges stiff and swollen (third day); dry and brown (fourth day); dry, brown at the tip, and lead-colored at the root (fifth day); covered with a brownish lead-colored coat in the centre, red at tip and edges (sixth day); clean, very dry, and red at the tip (seventh day); dry, glazed, and stiff, appearing as if baked, to the touch, with a hard crust formed on the surface (eighth day); clear, red, and somewhat more moist than last night, pointed at tip (ninth day); red and dry (tenth day); red, dry, cracked, and bleeding (eleventh day), 155.
Tongue covered with a whitish-yellow, dry, thick coating (next morning), 124.
Tongue discolored brown, and at last quite black, 64.
Tongue covered with mucus, 64. [260.]
Tongue clean, 42.*
Prickling in the tongue, 84.
The tongue was often terribly bruised and bitten, 37.
Tongue slightly creamy on the surface, 131.
Very painful crawling in the tongue, the tip of which was spasmodically moved about, 42.
General Mouth.
Fetid breath and exhalations, so that it was almost impossible to remain in the room even with a constant circulation of air (eleventh day), 155.
Fetid breath (tenth day), 155.*
Mouth either spasmodically drawn or closed, 63.
Mouth sore and bleeding; passive hæmorrhage (ninth, tenth, and eleventh days), 155.
Dryness of the mouth and nose, obliging him to drink much, not relieved thereby, 127. [270.]
Dryness of the mouth and nose, 127, 128b.
Scalding and burning in the mouth, throat, and stomach (eighth day), 155.
Sensation as of boiling water running from the vulva up to the mouth (seventh day), 156.
Mouth sore, as if salivated (ninth day), 155.
Saliva.
Constant salivation, 139.
Accumulation of saliva (after one hour), 127.
Salivation, 127b, 128, 128b.*
Increased salivation, lasting two hours (after one hour), 148.
Expectoration of bloody saliva (ninth day), 155.
Frequent running of water from the mouth, 84. [280.]
Froth from the mouth bloody, yellow, or green, 34.
Flowing of frothy bloody mucus over the lips, 47.
Constant inclination to spit (after half an hour), 94.
Taste.
Fetid taste in the mouth (tenth day), 155.
Nauseous taste, 152 ; (after one hour), 128.
Taste very much blunted, 84.
Taste flat, disagreeable, 64.
Much sour-tasting salivation (fourth day), 124.
Taste bitter, spoiled, 12.
Nauseous bitter taste, 170. [290.]
A peculiar taste in the mouth, as if he had smoked tobacco for a long time, or taken some ethereal oil (after a quarter of an hour), 124.
Inability to taste or bear food, 90.
Bitter taste in the mouth, in the morning (second day), 126a.
Speech.
Stammering and hesitation in answering questions (first day); the same hesitation still observable, but mind clear (eighth day), 155.
Stammering speech, 139.
The patient stammered unintelligible words between the teeth, 64.
Speech difficult, stammering, 70.
Inability to speak distinctly, 70.
Speech slow and weak, with a feeling on every motion as if there were always some resistance to be overcome, 48.*
Speech difficult, 142.*

THROAT. [300.]

Hawking up of tenacious mucus, with pressive pain in the right tonsil, 109.
Dryness in the throat, 138, 152, 170.*
Great dryness and irritation of the throat, which was intensely injected with blood, and on the left side of the soft palate was a dark patch looking as if blood was effused beneath the mucous membrane, 157.
Throat sore, with difficulty of swallowing, at 10 A.M.; œsophagitis; inability to swallow while lying down, at 8 P.M. (second day); not as sore (third day), 155.
Soreness and tightness about the throat (second day), 204.
Violent burning in the throat, 84.
Intolerable crawling in the throat, 48.
Burning in the fauces and along the œsophagus to the stomach (second and third days), 156a.

STOMACH

Appetite.
Excessive appetite; ate enormously of whatever was given him, 32.*
Very great appetite in girls, two, five, and eight years old, 70. [310.]
Ravenous appetite, 86.*
Insatiable appetite, 77, 82.*
Unusually great appetite, 70.
*Unnatural appetite, even when dying from exhausting discharges from the bowels, 35.
Increased appetite, 84.
Ravenous hunger, with improvement after eating, 106.
Ravenous hunger, 138.*
Constant ravenous hunger after the spasms, special desire for bread, 142.
A kind of ravenous hunger and mental weakness for a long time, 76.
Greediness; anything satisfied him; constant longing for food, 139. [320.]
Extreme greediness, especially for acids, 47.
Patients eat a great deal without being nourished, 32.
Bulimia, 34.
Increased hunger, 76.
Desire to eat through the whole illness, 42.
The appetite is either natural or ravenous, 61.
Ate more than usual (second day), 124.
Appetite moderately increased, 64.
Loss of appetite, 90, 95, 100 , etc.
Great aversion and inclination to vomit (after two hours), 69. [330.]
Aversion to food, 64, 84.
Complete disgust for food, with an occasional feeling of coldness at the stomach that thence pervaded the whole frame, 108.
Loathing of food and drink (tenth day), 155.
Anorexia, for two days, 151.
Thirst.
*Constant and intense thirst, 157.
Intense thirst, with no abatement by iced water or lemonade (second and third days), 156a.
*Great thirst, 84, 160.
Great thirst, but unable to drink much on account of its causing distress in the stomach (eleventh day), 155.
Great thirst and dryness of the mouth and throat, with burning and tingling of the tongue (seventh day), 155.*
Urgent thirst, with a desire for acidulated drinks (first day); loathes everything except sour drinks; desires acids (third day); great thirst and desire for sour drinks (fourth, fifth, and sixth days); thirst (seventh day), 155. [340.]
*Unquenchable thirst, 61, 64, 100, 153.
Excessive thirst , for two days, 151.*
Violent thirst, 47, 135, 153.*
Thirst, 131, 155, 161.*
Desire to drink undiluted wine at dinner, an unusual circumstance, 126.
They constantly long for drink, and desire to have the limbs stretched; with incessant pain and oppression, and pressure in the pit of the stomach, and constant ineffectual efforts to vomit, 47.
Thirst and dryness in the throat, 64.
Eructations and Hiccough.
Eructations having the odor of ergot, 108.
Frequent eructations of offensive flatus (fourth day), 124.
Frequent eructations (after one hour), 128. [350.]
Sour eructation, 148 ; (fifth and sixth days), 155.
Eructations, 64 ; (after one hour), 127 ; (after two hours), 130.
Singultus (fifth, seventh, and following days), 155.
Heartburn.
Heartburn, 64.
Nausea and Vomiting.
Nausea, 64, 66, 71 , etc.*
Excessive nausea and debility, with very little vomiting of a dark-brown, coffeegrounds fluid (first day); incessant vomiting of a brownish water, with occasional streaks of blood (second and third days), 156a.*
Nausea, after the chill, relieved by the diarrhœa, 136.
Constant nausea, all day, 78.
Nausea, caused by the odor of the plant, 74.
Nausea, after eating, 127. [360.]
Either nausea, and consequently sedation, or diminished frequency of the pulse, without nauseating, in twenty-five or thirty minutes, 103.
Slight nausea (after thirty minutes); nausea increased (after forty minutes); vomiting (after forty-five minutes); slight nausea (after one hour); no nausea (after two hours), 120b.
In three cases it produced slight nausea but no vomiting, 103.
Transient slight nausea (after each dose), 96.
A sensation resembling nausea alternated with the heavy confused feeling in the head (after half an hour), 94.
Nausea for twenty-four hours, 84.
Nausea and vomiting, 98 ; (after three-quarters of an hour), 106.*
Nausea, with occasional vomiting, 100.
Constant retching and vomiting of raw very offensive bilious substances, 61.
Incessant retching, with pressure in the pit of the stomach, 70. [370.]
Constantly retching, and could not retain a particle of either food, drink, or medicine on her stomach, 157.
Inclination to vomit, 126, 128, 128a.
Sinking and sickness at the stomach (sixth day), 155.
Sometimes sickness of the stomach, 81.
Sensations similar to those, attending sea-sickness (after half an hour), 94.
Fruitless efforts to vomit, 127.
Violent vomiting, followed by death, 143.
Violent vomitings, 118.
Sudden attacks of incessant vomiting, at night, with most violent headache and pain over the whole body, 140.
Vomiting, followed by relief, 127a. [380.]
In two, violent emesis (in one hour), 103.
Easy vomiting, 78.
Vomiting, 28, 64, 67, 76 , etc.*
Vomiting of dark-brown slimy mucus, and also of everything taken into the stomach (first day); greater irritability of the stomach, and more difficulty of retaining food and medicine is observed at 8 P.M., than in morning (second day); vomited twice (second night); some nausea and vomiting, at 8 P.M. (fourth day); nausea and vomiting of sour dark-green matter (fifth day); vomited a pint of matter, in the morning, very sour, and of a dark-green color (sixth day); vomited sour dark-green mucus, containing shreds of disorganized membrane (seventh day); matter vomited contained shreds of mucous membrane (eighth day); vomiting of dark bilious matter, at intervals of a few minutes; constant nausea and vomiting; matter vomited is of a dark-green color, containing mucus, bile, and shreds of membrane, in the evening (ninth day); stomach can not retain even medicine or water (tenth day); vomiting of blood , bile, membrane, and coffee-grounds matter; inability to retain anything on the stomach; vomiting ceased eight hours before death (eleventh day), 155.
Vomiting of mucus or of worms, giving relief, 61.
Hæmorrhage from the stomach (tenth day), 155.*
Frequent vomiting of food, 153.
Mucous and biliary vomiting, 152.
Occasional vomiting of coffee or chocolate colored matter, for two days, 151.
Vomiting of chocolate-colored substances, 153. [390.]
Vomitings of bilious matters; intermixed with blood, 119.
Violent vomiting of tenacious bilious mucus, at times affording relief, 47.
Vomiting of tenacious mucus, in the morning fasting, 82.
Vomiting of sour matters or of tenacious mucus, 64.
Vomiting of hardened black bile, 64.
Vomiting without great effort, soon after eating the bread, especially after a hearty meal, without diminished appetite, 72.
Vomiting of a slimy substance and frequently of round or thread worms, 64.
Stomach.
Tenderness of the epigastrium (second and third days), 156a.*
Great weight and oppression at the pit of the stomach, as if a stone were in the stomach (tenth day), 155.
Weight and oppression of the stomach (tenth day), 155. [400.]
Great distress and oppression at the stomach (tenth day), 155.*
Oppression at the stomach, 134.
Epigastric oppression, 152.
Oppression at the stomach, 134.
Feeling of weight at the epigastrium, 125.
A sensation of weight in the epigastrium, which, slight at first, became in a short time very painful, 108.
Unpleasant pressure at the stomach, which increased to such an extent as to obstruct his breathing; along with this there was a strong desire to eat (after three-quarter of an hour); the pain in the stomach was very tormenting, and attended with pyrosis (next morning), 124.
Pressure in the epigastric region (after three-quarters of an hour), 106.
Pressure in the stomach, 70.
Pressure and disagreeable sensation in the pit of the stomach, a kind of cardialgia, without loss of appetite, 42. [410.]
Frightful pressure in the stomach for four days after a dose, 84.
Pressure in the pit of the stomach, 47, 48.
Violent pressure in the stomach, 34.
Great irritability of stomach, toast-water, lemonade, and ice-water being ejected almost as soon as swallowed (second day), 156.
Very irritable stomach, 85.
Gangrene of the stomach, lungs, and liver, preceded by inflammation, 15.
Cardialgia, 34.
Spasm of the diaphragm (pleurospasmus), associated with suffocative loss of speech and twitching of the muscles, 61.
Painful sensation in the epigastric region, 64.
Violent pain in the epigastric and hypogastric region (first day), 155. [420.]
Pain and soreness in the stomach (seventh day), 155.
Pain in the stomach and bowels (sixth day), 155.
Pain in the pit of the stomach, 127, 127b, 128b.
Little pain or soreness in any part of the body except the stomach (eleventh day), 153.
Pain in the stomach, 132.
The pain in the stomach and waterbrash were most distressing (fourth day), 124.
Pains in the stomach and abdomen, 100.
Pain and cramp of the stomach, 99.
Attacks of violent cramps in the stomach, 61.
Cramp in the stomach, 62. [430.]
Gastric disturbance, 64.
Spasmodic constriction of the stomach, with nausea and vomiting, 146.
Painful constriction at the epigastrium (after one hour), 126.
Uneasiness at stomach (after one hour), 126a.
Warmth in the epigastric region (after one hour), 127.
Sensation of warmth and excitement in the epigastric region, 69.
Prickling in the stomach almost agreeable, relieved in the open air, recurring in a warm room, 109.
Sensation of burning in the internal organs, 64.*

ABDOMEN

Hypochondria.
Tenderness in the right hypochondriac region (ninth day), 155.
Pain in liver, stomach, and bowels (tenth day), 155. [440.]
Torpidity of the liver (tenth day), 155.
General Abdomen.
Abdomen tympanitic (first and fifth days), 155.*
Meteorismus, 64.*
Abdomen tense, 146.
Abdomen distended, 42.*
Abdomen very soft, 135.
Abdomen hard, tense, painful to touch, 42.
Soreness, bloating, and rumbling of wind in the bowels (seventh day), 155.
Rumbling of wind in the bowels (fifth day), 155.
Borborygmi (after two hours), 130. [450.]
Convulsive colic, 63.
Violent colic, 77.
Colic, 76, 113 ; (after two hours), 130.*
Griping pains accompanied stools, 166.
Complained urgently of abdominal and epigastric pain, 151.
Severe paroxysms of abdominal pains, recurring every fifteen minutes, and lasting hardly sixty seconds (after one hour), 168.
Abdominal pain, 170.
Pain and soreness in the bowels (seventh day), 155.
Patient describes the pains in the bowels as if a hundred knives were drawn through the parts down to the womb, ovaries, urethra, and vulva (eighth day), 155.
Severe pain in abdomen, which was swollen, tense, and exquisitely tender, 149. [460.]
Pain in the abdomen and burning in the stomach, 153.*
Painful contractions in the upper abdomen (after one hour), 123.
Spasmodic tension of the abdomen, 142.
Pressure as from much flatus in the abdomen, 110.
Pressure and drawing into the abdomen, relieved by slight stroking with the hand, 109.
A coarse stitch suddenly extending from the abdomen into the right testicle, while coughing, 109.
Paralysis of the intestines towards the last, 139.
Sensation of remarkable coldness in the abdomen and back, 61.*
Sensation of coldness in the abdomen and back, 47.
Sensation of disagreeable coldness, horripilation of the abdomen, back, and limbs, 64. [470.]
Increased warmth in the abdomen, especially in the epigastric region, 69.
Hypogastrium.
Pressure and dragging in the hypogastrium, as from flatus, extending into the scrotum, in the evening, two days in succession, 109.
Sudden circumscribed pain in the lower abdomen (after delivery), 98.
Pains in hypogastrium region, 105.*
Occasional pain in hypogastric region, 81.
Burning pain in the lower abdomen, 98.

RECTUM AND ANUS

Paralysis of rectum (tenth day), 155.*
Anus stood wide open, 87.*
Stinging-cutting pains in the rectum; great irritability of the sphincter ani, with spasms (ninth day), 155.
Severe cutting pain in the rectum (tenth day), 155. [480.]
Pain and spasm in rectum (tenth day), 155.
Excruciating pain in hæmorrhoidal veins (tenth day), 155.
Distressing itching in the anus, 110.
Frequent ineffectual efforts for stool, 47.
Urging to stool, with pressive pain in the abdomen, relieved after a normal evacuation, in the morning (second day), 109.
Ineffectual desire for stool, 153.

STOOL

*Diarrhœa, 32, 47, 50 , etc.
Diarrhœa, lasting from five to fourteen days, very exhausting, 42.*
Very offensive diarrhœa, 64.*
Pernicious diarrhœa, 64.* [490.]
Diarrhœa; frequent, brown, and slimy discharges from the bowels (first day); diarrhœa continued, discharges from the bowels very fetid, and dark-colored (second day), 155.*
Diarrhœa; the stools were of a dark-gray color, looked as though meal had been stirred through them, and had a peculiar sickly indescribable odor, 166.
Sharp diarrhœa (after four hours); this yielded to repeated hot baths; but for two weeks there was constant tendency to diarrhœa, 168.
Three or four hours after the chill, spontaneous diarrhœa commenced, continuing five or six hours, 156.
Thin involuntary discharges from the bowels, 62.*
*Stool thin, olive green , for the second time in the forenoon, without colic, followed by persistent burning extending, high up in the rectum, itching in the anus, making him almost beside himself (second day), 109.
Stool at first mucus, afterwards bilious or sanguinolent, 119.
Discharges from the bowels of a great quantity of disorganized mucous membrane, resembling that thrown off in dysentery (eighth day); movement from the bowels of watery feculent matter (eleventh day), 155.
Hæmorrhage from the bowels (ninth day), 155.*
Hæmorrhage from the bowels (tenth day); hæmorrhage; the blood does not clot, and is very thin and almost black (eleventh day), 155.* [500.]
Evacuation of worms, 47 ; in children, 48.
Motion of the bowels for the first time since taking the Secale (fourth day), 124.
Constipation, 64, 82, 145, 155.*

URINARY ORGANS

Great sensitiveness of the bladder and ovarian region (sixth day), 155.
Paralysis of bladder (tenth day), 155.*
Spasm of meatus urinarius (ninth day), 155.
Cutting pain and smarting in the urethra, as if a knife were drawn through the parts, when attempting to urinate (fifth day), 155.
Burning in the urethra during micturition, 84.
Frequent desire to urinate, though not without effort, 84.
Violent but ineffectual urging to urinate, 153. [510.]
Obliged to urinate at night, contrary to habit, also no desire to urinate, in the morning, yet a large quantity of clear urine was vigorously passed during stool, 109.
Copious micturition, 115.
Involuntary micturition, 87.
Micturition difficult, with constant desire in the bladder, 42.
Micturition seldom, dribbling and without relief, 47.
Retention of urine, 145.
Inability to pass water, 151.
Increased discharge of urine, 84, 146, 147.
Frequent and pretty copious discharges of urine (after second dose), 94.
Urine somewhat increased (after two hours), 130. [520.]
Urine scanty and dark-colored (first day); urinary discharges of a dark wine, or "prune-juice" color (second day); suppressed; on introducing the catheter, about a gill of dark prune-colored urine passed, which appeared to be full of gritty sediment, and emitted a very disagreeable odor (third day); suppressed but on using the catheter, about a teaspoonful escaped, which was very dark and fetid; a few drops falling on the linen stained dark brown; only a few drops passed during the day (fourth day); suppressed , passed three tablespoonfuls of urine by means of catheter, of a lighter color than formerly (fifth day); procured a tablespoonful of urine by the use of the catheter, at 9 A.M.; passed a tablespoonful containing albumen, at 8 P.M. (sixth day); scanty discharges from the bladder of a yellow color, and very fetid; contained a large amount of albumen (seventh day); thought we detected casts of the uriniferous tubes in the ounce of albuminous urine obtained by means of the catheter (eighth day); albuminous, but of better color and larger quantity than at any time since the suppression commenced, containing mucus and albumen (ninth day); kidneys more active; urine more copious, but albuminous, fetid (tenth day); passed involuntarily for the first time in her sickness, more copious and containing blood and albumen (eleventh day), 155.
The urine has a white sediment like cheese, 85.
Profuse thick red sediment to the urine, that colors the vessel, 84.
Urine scanty, watery, clear, 64.
Urine as clear as spring water, at times turbid, 51.
Urine clear, like water, 12.
Urine pale, 135.

SEXUAL ORGANS

Male.
Numerous erections, even after coition, 109.
Strong dragging in the spermatic cord, so that the testicles seemed drawn up to the inguinal ring; this lasted for half an hour (after three-quarters of an hour), 124.
Female.
Abortion, period about two months, mass perfectly black, 149. [530.]
Abortion, 83.*
A six months' fœtus was born; the discharge of the placenta was immediately followed by profuse vomiting, violent jactitation, præcordial pain, pallor, coldness of the surface, the uterine contractions recurring at irregular intervals; this continued for half an hour, until unconsciousness and strabismus ushered in death, 151.
Death of the fœtus, 107.
Miscarriage, followed by tearing pain in the extremities, 141.
Miscarriage between the seventh and eighth months, 163.
Uterus and right ovary much congested and very sensitive to the touch ; sphincter vaginæ and vagina very much relaxed (eighth day), 155.*
On examination per vaginam found the os tinca open so as to admit the first phalanx of the index finger, very sensitive to the touch, hot, and engorged, with profuse flowing (first day), 155.
Os uteri wide open, thick, soft (before delivery), 98.
The uterus, that had previously been in a normal condition, descended so that it almost protruded from the labiæ, was hot and painful; the os was open as large as the middle finger; the patient complained of excessive desire to urinate, and of labor pains, only relieved by wet bandages or by pressure upon the abdomen; this lasted three days. She did not miscarry, though the os remained open during this period; afterwards the uterus gradually ascended, the pains diminished and after five or six days the os again contracted. The woman went on to the eighth month, when she miscarried, 169.
Retention of the placenta due to hour-glass contraction of the uterus and subsequent sterility, 107. [540.]
Uterine hæmorrhage, 149.
Hæmorrhage from the uterus, and apparent death of the new-born child, 88.
Incessant metrorrhagia, 153.*
Gangrene of the whole vaginal mucous membrane; on holding a part the labiæ this membrane was found of a dark slate-color, emitting the characteristic odor, 118.
Vagina hot, 98.*
Discharges from the vagina almost black, fluid, and very fetid (second day), 155.*
Vaginal and urinary discharges of a dark wine or "prune-juice" color (second day), 155.
*Cessation of the lochia, with fever, inflammation of the uterus; subsequently an abscess that opened through the vagina, 98.
Pains in ovaries and uterus (tenth day), 155.
*Pains of an expulsive character in the uterus (first day), 155. [550.]
*The drug causes, not regular intermittent, but irregular stormy contractions of the uterus, 107.
*Violent labor pains, 163.
Tenderness of the vulva (fifth day), 155.
Great tenderness of the vulva (tenth day), 155.
Pain in the vulva (sixth and tenth days), 155.
Pain, soreness, and throbbing heat in the vulva (seventh day), 155.
The menses are too profuse; congestion of blood to the uterus; metrorrhagia; excessive uterine contractions, so that the uterus seemed ready to burst; all the symptoms are worse previous to the menses, 129.
Suppression of the menses, 47, 111.

RESPIRATORY ORGANS

Voice.
The voice became weak, unintelligible, stammering, 64.*
The voice is weak and unintelligible, stammering, 61.
Cough and Expectoration. [560.]
Loose cough, with easy expectoration of much tenacious mucus, 109.
Blood was sometimes expectorated during violent efforts to breathe, 64.*
Respiration.
Respiration costal (first day), 155.
Respirations 15, 125a.
Respirations, 21 (before experiment); 20 (after one hour), 126.
Respirations, 19 (before experiment); 8, slow and small (after three hours), 94.
Respiration fell from 18 to 13, 106, 108.
Difficulty of breathing caused by contractions of the diaphragm, 145.
Respiration difficult, 64.*
Difficult respiration, as if a weight were lying on the chest, in consequence of which he was obliged to take deep and forced inspirations (after one hour), 126a.* [570.]
Laborious breathing, 115, 149.*
*Constant sighing (sixth day), 155.
The respirations decreased from 18 to 13 per minute, 108.
*Anxious respiration, 64.
Anxious difficult respiration, 42.*
*Anxious breath, sighing, and hiccough, 61.
Most violent asthma appeared after the suppression of the itch, and ceased on the reappearance of the eruption, 79.
Dyspnœa, 42, 122.*
Great dyspnœa before death, 138.

CHEST

Oppression of the chest, 47, 50. [580.]
Sharp pressure in the sternum, 109.
Pressure in the chest, 132.
Pain in thorax, 99.
The whole upper portion of the left side of the chest, with the sternum, was painful, 110.
Suppression of milk; this effect has been noticed in six nursing women, 154.
The milk will not flow from the breast of a nursing woman, 42.

HEART AND PULSE

Heart.
Præcordial tenderness, but no fulness, 157.
The sounds over the præcordial region are perfectly normal, but convey an impression of slowness of time-taking action, 131.
Pressure in the præcordial region, 64.
Painful sensation in the præcordial region, 64. [590.]
Great præcordial anxiety, 100.
Præcordial anxiety, 153.
Disagreeable sensation in the præcordial region, 67.
Spasmodic throbbing of the heart, 64.
Violent palpitation, with contracted, frequently intermittent pulse, in an acute form of poisoning, 61.
Palpitation of the heart (after half an hour), 104.
Distressing palpitation, 110.
Her heart she described as having beat very rapidly for a long time, and her breathing as having been exceedingly laborious. After some hours the heart beat more quietly for a time, and then fell into inordinate activity as before; intermitting in this manner throughout the day, during the earlier part of which she lay perfectly motionless, but without pain, recovering gradually towards evening the suspended animal function, 45.
Pulse.
Rapid pulse, 127b, 128b.
Pulse rapid, small, hard, 149. [600.]
Pulse rather quick, but very small and feeble, 157.
Pulse very feverish, 48.
Rapid pulse, 153.
Accelerated pulse, followed by sleepiness, 148.
Pulse accelerated, 83.
Pulse quick, 151.
*Pulse small, very rapid, contracted, frequently intermittent, 64.
Pulse 112, 87.
Pulse 90 and small, 135.
It appeared to excite rather than diminish the pulse, in twenty-five or thirty minutes; in fifteen or twenty minutes, however, the pulse lost a few beats in a minute, but not to the same extent when given in larger doses, 103. [610.]
Pulse weak and rapid, 119.*
Fall in the pulse, 170.
Pulse weak and slow, diminished by 7 beats, 122.
Pulse slow, falling 75 to 52, 106.
Pulse small and contracted, 145.
Pulse small, soft, and slow, 146.
Pulse small, 138.*
Pulse small, slow, and suppressed, 100.*
Slowness of the circulation, 85.
Pulse small, contracted, 54. [620.]
Pulse slow, 32 (beats), 70.
Pulse slow, indolent, 70.
Pulse slow, at times full, at other times small and tense, 71.
Pulse slow, weak, in three girls, 70.
Pulse slow, small, at times intermittent and scarcely perceptible, during the spasms, 47.
Pulse slow, small, thin, 164.
Pulse slow, 147.
Pulse very small accelerated, 166.
Weak depressed pulse, 92.*
Pulse and respiration very slight and infrequent, 95. [630.]
For three days the pulse continued below 50, with a proportionate infrequency of the respiration, 95.
A diminution in the frequency of the pulse, and in several of the volume, were the only phenomena observed, except in three cases, 103.
Pulse 58, 125a.
Pulse depressed, very quick, and fluttering, ranging to 120 per minute (first day); 120, small and compressible (second day); 110, somewhat fuller than the day before, at 9 A.M.; 100, quite full, at 7 P.M. (third day); 90, full, but easily compressed, at 8 P.M. (fifth day); 90, appears to have more volume, but easily compressed, at 9 A.M.; 100, not as full and wiry, at 8 P.M. (sixth day); 100, small and feeble, at 9 A.M.; fuller with more volume, at 4 and 8 P.M. (seventh day); 92, full, at 8 P.M. (eighth day); 80, full, while quiet, but quick and very feeble while making the least exertion (ninth day); 80, moderately full, but easily compressed (tenth day); 80 to 90, weak and variable, at 10 A.M.; feeble, intermittent, ranging from 80 or 90, at 3 P.M. (eleventh day), 156.*
Pulse, before taking, 84; counted every fifteen minutes was as follows: 76, 74, 72, 68, 70, 68, 66, 66, 64, 62, 62, 62, 64, 64, 64; afterwards perfectly regular, only somewhat depressed, 130.
Pulse, before taking, 84; counted every quarter of an hour was as follows: 80, 80, 80, 78, 78, 76, 78, 76, 76, 74, 76, 74, 72, 70, 70, where it remained for over an hour, without variation, 130a.
Pulse 82 (before experiment); 36, slow and feeble (after three hours), 94.
The pulse, usually about 80, sank to about 40, with frequent intermission, and so continued through the night (after half an hour), 104.
Pulse 79 (before experiment); 72 (after one hour), 126a.
Pulse 74 (before experiment); 62 (after one hour); 60, small and weak (after three hours), 126. [640.]
Pulse 70 (before experiment); 60 (after thirty minutes and one hour); 57 (after one hour and a half); 60 (after three hours), 121.
Pulse 70 (before experiment); 64 (after thirty minutes); 60 (after one hour); 56 (after two, and three hours), 121a.
Pulse 67 (before experiment); became soft, small, feeble, and fell to 60, 125.
The pulse, which before the experiment was 65, fell to 54, small and slow, 108.
Pulse 64 (before experiment); 58, moderately full (after twenty minutes); 48, small (after thirty minutes); 48 (after forty-five minutes); 52 (after sixty minutes); 55 (after seventy-five minutes); 60 (after six hours), 120.
Pulse 64 (before experiment); 52 (after twenty minutes); 46 (after thirty-minutes); 45 (after forty minutes); 60 (after forty-five minutes); 46 (after on hour); 50 (after two hours), 120b.
Pulse 60 (before experiment); 52, full and tense (after twenty-five minutes); 51 (after thirty-five and forty-five minutes); 54 (after one hour); 56 (after one hour and a half), 120a.

NECK AND BACK

Stiffness in the nape of the neck, 48.
The cervical muscles of the right side were stiff and painful on turning the head (second morning), 109.
Pain in the back and small of the back, with dragging and pressure in the lower abdomen, relieved by stooping (second day), 109. [650.]
Pain in the back (second and third days), 156a.*
Pain in the small of the back, 138.*
Violent pain in the small of the back (first day), 155.

EXTREMITIES

Most violent convulsive movements of the limbs occur several times a day; during the intervals the fingers are numb and often contracted, 70.*
The extremities were alternately violently flexed and extended, with an irresistible desire to stop the spasm by the force of the will, which he was imperfectly able to do, 64.
General convulsions of all the extensor muscles, and indeed a perfect access of puerperal convulsion under its peculiar form (soon after second dose), 117.
Sudden periodic contractions of the limbs , with tensive pain, 33.*
Convulsive movements of the limbs, 70.*
The limbs were very stiff, affected by the most violent spasms; yet there was an irresistible inclination to overcome the spasmodic contractions, so that as long as the spasm affected the extensor muscles there were constant attempts to flex the limbs, and when the flexor muscles were affected to extend them, 61.
Wonderful distortions, alternate flexions, and distensions of the limbs; even the fingers were violently bent backward, 64. [660.]
Contractions of the hands, feet, fingers, and toes, which the strongest man cannot prevent, 34.*
Various slow pandiculations and distortions of the hands and feet, especially in children, 42.
Spasmodic contortion of the extremities, 165.
Contraction of the flexor tendons, as though we would hop about, 165.
General trembling of the upper and lower extremities, especially on exertion, 140.
Trembling of the limbs, with bitter taste, 1.
The limbs trembled easily, 64.
Trembling of the limbs, 71, 142.*
Trembling of the limbs for several days, 72.
Indolence in the limbs, 3. [670.]
Distortion of the hands and feet, 77.
Arms and legs rigid, in a semiflexed and semipronated posture; pain on attempting to straighten the limbs, 138.
Paralysis of different limbs, 64.
Paralysis of the limbs, 62.
Complete inability to walk, and remarkable inability to give the slightest grasp of the hand, or to execute any movement, even though the patient did not seem excessively weak, 48.
Immobility and stiffness of the limbs, 48.
Rigidity of the limbs after the spasms, 34.
Complete stiffness of the limbs, 48.
Rigidity of one or another limb, 33.
Loss of all power in the extremities, so that the patient could raise neither the arms nor legs, was obliged to lie in bed, 140. [680.]
Swelling of the upper and lower extremities, sometimes with rash, vesicles, furuncles, ulcers, and exanthemata, after the spasms have lasted a long time, 61.
Gangrene of the limbs, the limbs suddenly became cold, leaden-colored, and lost all sensation, 12.
Real gangrene of the fingers or toes, 64.
Cold gangrene of the limbs, 80.
True anthrax, rapidly changing into gangrene of the limbs, 64.
The parts affected by gangrene spontaneously separated from the body, 35.
The dead extremity separated at the joint, 54.
Hands and feet swollen, with a gangrenous, black, and suppurating eruption, 15.
Hands and feet swollen, covered with blisters, 111.
Lost both feet and nearly all his fingers, 159. [690.]
The fingers and toes first became discolored and then actually gangrenous; this gangrene soon became general, even penetrating to the bones, in consequence of which, frequently, even during the life of the sufferers, the limbs fall off, 64.
Some lose their fingers or toes from cold gangrene without pain, and find them in their stockings or gloves, 80.
Pain, with some swelling, without inflammation, followed by coldness, blue color, cold gangrene, and death of the limb, 3.
*The limbs became cold, pale, and wrinkled, as if they had been a long time in hot water, 80.
After excessive lassitude, more or less protracted, and unaccompanied by fever, the extremities become painful, cold, and rigid; benumbed and almost insensible, the limbs were yet capable of movement, though with difficulty; the patients were afflicted with grievous internal pain, which was greatly increased by heat, whether of the bed or atmosphere, but abated somewhat when exposed to a cooler atmosphere, though even then it was scarcely tolerable; the pain extended by degrees from the toes to the legs and thighs, and from the fingers to the arms and shoulders, till sphacelus supervening, the affected parts, dead and black, dropped from the trunk or the adjacent members, 158.
The nails have fallen off his thumbs and all the fingers of both hands, as well as one of the lesser toes of the left foot, the denuded parts being covered with flabby granulations, secreting a fetid discharge, 131.
Nails purple, 132.
No blood followed the separation of the limb by the gangrene, 22.
The person generally experiences not the slightest pain in the gangrenous limb, whenever pricked or cut, though frequently motion is not entirely lost, 12.
Absolute insensibility of the tips of the fingers and toes, 140.* [700.]
Insensibility of the limbs, 37, 47.*
Numbness of the limbs (eleventh day), 155.*
Anæsthesia of the limbs or fingers, lasting a long time after the attacks, 145.
*Numbness, insensibility, and coldness of the limbs, 54.
Great weariness of the limbs; he could scarcely drag along the feet, 84.
Weakness of the limbs, so that movement of the fingers was painful (after one hour), 123.
Weakness of the limbs, 86.*
The father and mother merely experienced lassitude in the limbs, 133.
Heaviness of the limbs, 48 ; (after three-quarters of an hour), 106.*
Limbs heavy, as if embarrassed with a great weight, and the calves painful (after one hour), 126a. [710.]
*Numbness of the fingers and toes, 140.
Disagreeable sensation of sleep and formication in the extremities, 98.*
Cramps in the legs, arms, and chest (after two hours), 166.*
Cramps in the hands, and feet, which were painfully contracted, 139.
Cramps of the limbs, accompanied with excruciating pains and formication, 99.
The limbs are affected by violent pain, 65.
Spasmodic pains in the limbs, 48.*
Incessant spasmodic pains in the feet and hands, changing from place to place, with constantly crying, 42.
Pains in the limbs, 48, 54 ; (second and third days), 156a.*
Pain in the upper and lower extremities, 138. [720.]
Pain and bruised sensation in all the limbs, 140.
Pains in all the extremities; cramps in the flexor muscles, 147.
Periodic drawing pains extending downwards in the knees and elbows, with loss of sensation, coldness of the skin, and difficult movement of the parts, 146.
Drawing in the hands and feet, 145.
Painful drawing and tearing in the limbs, 100.
Drawing and tearing in the hands and feet, 100.
Drawing and crawling in the limbs, 89.*
Drawing in the limbs, especially in the arms, 89.
Drawing or tearing pains in the limbs or joints, sometimes associated with a crawling sensation in the extremities, 64.
Violent jerking in the limbs, so that the patient was unable to separate or approximate the fingers, 20. [730.]
Severe pains in the limbs (first day), 155.
Tingling in the extremities, 165.*
Tingling in the fingers and feet (after two hours), 168.
Jerking pains in the limbs and gum, 70.
Violent burning in the hands and feet, and especially the fingers and toes, which were bent and stiff, 135.
Sensation of burning fire in the hands and feet, 34.
Burning in the palms of soles, 147.
Burning of the hands and feet, 34.*
Consuming fire in the hands and feet, 142.
*Fuzzy feeling in the limbs, 162. [740.]
Extension of the flexed limbs afforded some relief, 48.

SUPERIOR EXTREMITIES

Tonic spasms of the upper extremities, 86.
Shoulder.
Violent tearing pain in the right shoulder and upper arm, as if a string were tightly drawn around it, followed by painfulness of the muscles, for a long time, 109.
Pain in the left shoulder (sixth day), 155.
Very annoying pain in the left shoulder (fifth day), 155.
Arm.
Paralysis of the arm, 139.
Paralytic symptoms in the arms, with stiff and rigid flexion of the fingers, so that they could not be extended with the most acute pains, 100.
The arms fell asleep, 164.*
Wrist.
Soft, painful, watery swelling of the wrists, lasting several weeks, 42.
Hand.
The whole hand is drawn inward, so that the bones of the wrist are very prominent; the forearm is affected by spasms, and the hands are approximated to the chest; relief of the pain follows when one attempts to extend the flexed parts, 42. [750.]
Weakness of the hands; the patient could not hold anything securely, 140.
Contraction of the hands, 165.
The hands can with difficulty be carried to the mouth, the fingers are bent backward, and the eyes distorted, 61.
Crawling sensation in the hands and arms, 106.*
Fingers.
Gangrene, followed by spontaneous amputation of a finger, in one case, 145.
Fingers rigid, cold, shrivelled, painful to pressure, dry; hands covered with red erysipelatous spots, scales, and cracks, 111.
The fingers of both hands were flexed tightly into the hands, so that they could be opened with great difficulty; relief if the fingers were extended by another, but they immediately retracted again into the hand, 42.
Fingers so violently flexed that the strongest man could not extend them, 142.
The fingers were violently contracted, 37.
Contraction of the fingers, 89.* [760.]
Loss of sensation in the tips of the fingers, 35, 47.*
Numbness of the tips of the fingers, 70.*
Numbness of the fingers, 48.*
Most violent pains in the tips of the fingers, 85.
Violent pains in the ends of the fingers, followed by lymphatic swelling, extending up the arms, and by loss of the ends of the fingers, 112.
Cramps in the fingers, frequently lasting several weeks, especially in children, and making it impossible to work, 42.
Drawing in the fingers, 165.
A crawling numb sensation in the fingers for a long time, 100.
Crawling in the tips of the fingers, as if something alive were creeping under the skin, or as if the fingers were asleep, as from pressure upon the arm, 42.*
Peculiar prickling feeling in the tips of the fingers, that are very sensitive to cold ; after awhile they begin to suppurate, and later the nails separate from their matrix and fall off one after another, leaving and unhealthy granulating surface, 132.

INFERIOR EXTREMITIES. [770.]

Two of the youngest were attacked with gangrene. One, a boy, ten years of age, after eating the bread during fifteen days, felt a severe pain from the left groin to the calf of the leg. The feet and legs became tumefied, covered with phlyctenæ, and the gangrene appearing at the inferior third of the legs, descended toward the feet and ascended to the upper part of the legs, where it became limited. The other, aged twenty-eight months, was attacked in the same way, but on one leg only, 133.
Convulsions of the lower extremities and most violent pains, 146.
The patients are able to walk only on the tips of the toes, on account of constant cramplike spasmodic contractions of the limbs, 61.
The lower limbs were flexed; she could not stand upright, and reeled as if intoxicated, yet was perfectly conscious, 42.
Occasionally slight convulsive twitches in the lower extremities were experienced by two of the individuals, 105.
Reeling gait, 145.
Gait difficult, tottering, 70.
Tottering gait, 86.
Inability to walk, 48.
Painful rigidity of the muscles, and an extreme lassitude in the lower extremities, causing considerable difficulty in walking (after second dose), 94. [780.]
Lower extremities paralyzed, 87.
Weakness of the lower extremities, so that the gait was unsteady and stumbling, 140.
Weakness and pains in lower extremities, 42.
Thigh.
Rigidity and soreness of the muscles, the muscles of the thighs and other parts of the lower extremities being more particularly affected, 95.
In the course of the day, a creeping sensation of insensibility upon the anterior part of the thigh and calf of the leg (second day), 124.
Leg.
Great weariness of the legs, followed by lasting pains, though worse at night, and would allow no sleep nor rest, 102.
Sense of weight and want of tone from the knees down, 131.
Painful sensation of weight in the calves and ankles (second day), 126a.
Occasional cramps in legs and feet, 131.*
Cramps in the calves, 165.*
Foot and Toes. [790.]
Gangrenous death of the feet and legs as far as the knees, 35.
Swelling of the feet, 48, 111.
Dropsical swelling of the feet, 47.
Inversion of the feet, 165.
Violent pains in the feet and calves, 140.
Cramps and weakness of the feet, 132.
Anæsthesia of the soles of the feet, 134.
The feet seem asleep and stiff, 100.*
The ends of the toes turned purple, suppurated, and fell off, 132.
Gangrene of the toes and legs, and dropping off of the joints, the cases terminating either in death or fatuity, 99. [800.]
Cramps in the toes, so that walking is impossible, 42.

GENERALITIES

Rapid emaciation, 35.
Child loses flesh, 116.
Hot gangrene, that eats the flesh from the bone, 23.
Cold gangrene and death attacked the nose, fingers, hands, arms, feet, tibiæ, and thighs, 3.
Dry cold gangrene, 34.
The gangrenous parts became black and separated from the body, 12.
Gangrene, 66.
Emphysematous swelling, 64.
Apoplexy, 63. [810.]
Extreme exhaustion, gangrene, or apoplexy, sometimes most violent epilepsy, followed by death, 64.
Hands, feet, ears, and nose became purple, and much of the surface assumed a mottled aspect (after twelve hours), 104.
General adynamic condition, under which the patients commonly succumbed about the tenth or twelfth day from the attack, 119.
Indications of a puerperal state (eighth day), 135.
Secretions diminished, 116.
Opisthotonos, 34, 162.
Emprosthotonos, opisthotonos, risus sardonicus, and raving, 47.
Emprosthotonos, 42.
Convulsive movements and twitching of the muscles and tendons of the limbs; twitchings of the muscles of the face (tenth day); twitching of the muscles (eleventh day), 135.
Violent paroxysms, consisting of contractions of the extremities, repeated at short intervals until the extremities became cold, stiff, and immovable, with violent pains in various muscles; in some cases the attacks became tetanic, with trismus and opisthotonos, or even epilepsy, followed by weakness of memory; the attacks frequently occurred suddenly in the night, 145. [820.]
Most frightful convulsions, followed by tetanus, 143.
Paroxysms usually better at night, so that the patient could at times sleep quietly, 100.
Convulsions, 66, 99, 141, 165.
Convulsions, etc., the convulsions sometimes carrying off the patient, 116.
Strong general convulsions (after twelve hours), 104.
Frightful convulsive movements and spasms, 42.
Spasms, followed by death, 15.
Convulsions, followed by death, 42, 73.
She died in violent convulsions, 135.
Spasms, 28. [830.]
Violent spasms, followed by anæsthesia, complete loss of sight and hearing, and coma, 44.
General spasms, similar to epilepsy, 14, 61.
The spasms are especially brought on by emotional excitement, followed by exhaustion, weakness, and sopor, 142.
Repeated spasms, 139.
Extremely painful tonic contractions of the muscles, with opisthotonos, great anxiety, and loud cries; these attacks lasted from half an hour to several hours, 142.
The whole body was tossed about with the greatest uneasiness, and the person covered with cold sweat, 47.
Clonic spasms, that in some parts of the body changed to tonic spasms or alternated with them, 64.
The most violent spasms seemed to recur periodically, so that the recurrence of a new attack could be foreseen, 42.
The most violent spasms occurred at night; the sweat associated with them seemed to be caused rather by the anxiety than the pains, 42.
Most violent tonic spasms in the muscles of all the extremities, 160. [840.]
Tonic spasms, 161, 165.
Slight tetanic contractions of the face and extremities, which yielded to repeated hot baths (after one hour), 168.
The muscles subject to volition responding irregularly, with occasional violent spasms of the muscles of the extremities and back (second and third days), 156a.
Spasms and twitchings, followed by death, 47.
Spasmodic movements of various kinds, 64.
Painful spasms, that lasted several weeks, 15.
Spasms and twitchings of the upper and lower extremities; spasmodic contractions in the veins, 70.
Sudden epileptiform spasms, with loss of consciousness, 147.
Epileptiform spasms, 32.
Epileptiform spasms in children, followed by death, 48. [850.]
Epileptiform spasms, occurring at intervals of about a month, during which the patient lost her memory, became foolish, and spoke with difficulty, 147.
Completely developed epilepsy, occurring from time to time, gradually succeeded by idiocy, generally fatal after six months, 89.
Epilepsy, especially in children, 42.
Epileptic attacks, 165.
Epilepsy, 34, 48, 62.
In some patients the spasms occurred without remission or without aggravation at any time of day, and these were in great danger, 42.
In most cases the spasms attacked the patient without previous unpleasant symptoms, and if no remission followed the patient died on the third day, 42.
The spasms changed often from clonic to tonic, even to tetanus and trismus, 64.
The spasms generally occurred in the forenoon, lasted a longer or shorter time, were always followed by great weakness, sometimes by complete stiffness of the neck; the patient was relieved by rubbing and stretching the limbs; every emotional excitement caused a new attack, 47.
The spasms occurred two or three times a day; during the interval great weakness, contractions of the lower extremities, so that at times the patient could walk only on the toes, numbness of the limbs, especially of the fingers and toes, 64. [860.]
The spasms lasted usually two to four hours, sometimes twenty-four hours, and ended with profuse perspiration, 64.
Sudden vertigo and blindness; the patients were deprived wholly or in part of their senses, fell to the ground, and suffered the most violent contraction of the joints, twitching of the limbs, trembling, and violent ineffectual efforts to vomit; the elbows were pressed against the chest, the wrists flexed, the fingers doubled into the hands, the heels drawn upward toward the tendo Achillis, the toes bent under the sole of the foot, and frequently two strong men could not stretch out the limbs, 47.
After the spasms there were often distortion of the limbs, dilated pupils, loss of consciousness, delirium, weakness of mind or a certain insensibility, in which she seemed to be lost, staring at any one who spoke to her and answering nothing, as if she did not understand; others seemed paralyzed, were unable to stand or walk, 42.
Violent trembling from every effort, even on stretching out the tongue, 48.
General trembling, 146.
Trembling, weakness, and paralyzed, benumbed sensation, 141.
Trembling, 14, 48, 82.*
Irregular movements of the whole body, especially of the limbs, 98.
Unsteadiness of the whole body, 82.*
Painful stretching, 14. [870.]
Transient twitching, 47.
Violent jerking preceded the sensation of crawling, and was associated with most violent pains; these spasms were accompanied by constant trembling of all the muscles, and the spasms at first clonic became after a time tonic, and developed into a truly tetanic character, 41.
Numerous jerking movements of the voluntary muscles, 44.
Jerkings like electric shocks, almost as in tetanus, 138.
Jerking and spasms, 37.
Jerkings, 65.
Slight jerking and visible movements under the skin, 48.
Complete paralysis, 48.
Paralysis, so that the patient could no longer walk, with weakness in the small of the back and trembling of the feet, 100.
Loss of sensation and paralysis of the parts previously affected by spasms, 61. [880.]
Muscular inertia so great that he could scarcely move the fingers, and had great difficulty in either writing or walking (after one hour), 126.
Paralytic symptoms, 100.
Lost all voluntary motion, and even the power of utterance, 115.
The vital forces were gradually exhausted and paralysis occurred; the skin of the affected parts began to desquamate; erysipelatous vesicles appeared over the whole body; the fingers and toes became gangrenous, with separation of the soft parts; the stools were thin, involuntary, followed by apoplexy and death, 61.
*Restlessness, 142 ; (sixth day), 155.
Great restlessness, 135, 151, 153.*
Restlessness, with frequent wailing or screaming cries, 116.
Extreme debility, 90.*
Extreme debility, numbness (occasionally of complete insensibility of the extremities), 99.
Feeling of complete prostration and vertigo on walking across the room, 108. [890.]
Great depression of strength and temperature of the body, 125a.
Great prostration, accompanied with a slow feeble pulse (second and third days), 156a.
Great prostration (second, fourth, and seventh days), 155.*
*Prostration, 106, 122 ; (after one hour), 126a ; (eighth day), 155.
Faintness, 64.
Exhaustion, 62, 70.
Great exhaustion, having no power to move the lower extremities, and but very little control over the upper, 97.
Great exhaustion after sleep, 84.
Long-continued indolence, with stupefaction, coldness, and insensibility of the limbs, followed by gangrene, 65.
Languor during the whole day (second day), 126a. [900.]
Great languor and lassitude (after half an hour), 94.
Extreme languor, 99.
General languor and lassitude, 95.
General lassitude (after one hour), 126.
Great weakness, 10.
Weakness, 12, 32, 47, 160.
Weakness and dizziness (after two hours), 166.
Very weak; cannot move herself in bed (third day), 155.
Loss of strength, 64.
Loss of strength, caused by exhausting diarrhœa, 47. [910.]
Weariness, 14.
Rapid sinking of strength, 54.*
Indisposition to move or speak; becomes very much exhausted when doing either (eleventh day), 155.
Great sensitiveness to cold, 111.
The parts affected by spasms became somewhat insensible, 64.
After the spasms ceased, loss of sensation, the fingers and hands became numb and the lips pale; the spasms mostly returned on the ninth day, 42.
Rigidity, loss of all sensation, and most violent pains, aggravated by warm air or by the warmth of the bed, somewhat relieved in the cold, but in its place there was a sensation of most intolerable cold in all the limbs and over the whole body, 80.
General discomfort, 100 ; (after two hours), 69 ; (after three-quarters of an hour), 106.
General heaviness, 105.
Great soreness all over the body; could not lie with ease in any position, and could not be moved without taking hold of her hands (second day); soreness of body not diminished (third day), 155. [920.]
Tetanic cramps for several days, and considerable stiffness of the limbs remained, so that she frequently fell in walking, 137.
Tetanic cramps, 134.
Sudden intense pain, so that he cried aloud and ran about as if mad, 142.
Gnawing-boring pains in the flesh, worse at night, permitting no sleep, 140.
Tearing pains and intolerable crawling sensation in the limbs, pain in the head and back, anxiety, and some insensibility in the arms and feet, 61.
Wandering pains over the whole body, especially in the back and small of the back, 63.
Obstinate periodical pains, 61.
Pains recurring every ten or twenty minutes, with slow contraction of the limbs, 76.
Pains causing screams, 63.
Transient sticking tearing moving from place to place, at times with, at times without cramps, 140. [930.]
Sensation of burning, as if sparks of fire were falling upon different parts, 61.
Drawing and crawling, changing sometimes rapidly, sometimes slowly, into violent pains and spasms; the limbs were flexed and the skin covered with sweat, 47.
Twitching tremulous sensation in single muscular fibres and in whole muscles, in the face and hands, 42.
On awaking, in the morning, she had a peculiar tingling sensation all over the body, sometimes merely a slight creeping feel, and at others the symptoms increased even to painfulness, 114.
*Heat applied to any part of the body aggravated his pains; his extreme aversion to warmth was very remarkable, and if on any cold day any additional covering was laid upon him while sleeping, he awakened almost instantly and threw it off; he was generally found in the coldest weather lying in bed with only an old cloak thrown over him, 159.
The symptoms increased for four days, 124.
All the symptoms are aggravated on the appearance of the menses, 33.

SKIN

Objective.
Exhalations from the skin, of a vinous odor (fifth day), 155.
Exhalations from the skin fetid (second day), 135.
Desquamation of the whole body three times, in a girl, 47. [940.]
The epidermis begins to loosen from the affected parts, 64.
Skin soft, flabby, 70.
Skin dry, rough, 64.
Dry and withered appearance of skin, 116.
The skin, which in general was inclined to perspiration, was constantly quite dry, 124.
Dryness of the skin, with no trace of perspiration, 139.
Skin dry and cool, 135.*
The capillary action of the skin was remarkably slow, a portion of the skin deprived of its blood, by pressure with the finger, being a long time in recovering its color, 94.
Capillary action very slow, 95.
Capillaries of the skin appear to be empty (seventh day); more blood in the surface veins (ninth day), 155. [950.]
Skin hot, dry, and of a yellowish-brown color, resembling that of a mulatto (second and third days); hot, dry, but not as dark as if was the day before (fourth day); hot and dry, but of a better color, of a natural appearance on the feet and hands (sixth day); soft and more natural to the touch, but still very yellow (ninth day); yellow, soft, and moist (tenth day); most and yellow (eleventh day), 155.
Skin dry and of a muddy-yellow hue (second and third days), 156a.
Skin discolored, 142.
Skin had a yellowish tint, 157.
The child, when born, was in a state of perfect jaundice, and continued so until death, which took place on the second day, 117.
Skin everywhere deep red, 149.
Skin of a roseate hue, 90.
The whole skin assumes a leaden hue, shrinks and wrinkles, and becomes insensible, 64.
The skin of the affected parts becomes leaden-colored and wrinkled, the vessels disappear, the parts gradually become numb and lose all sensibility, so that she can be cut and pricked without pain, or without blood flowing from the wounds, 61.
Petechial exanthema and furuncles on the lower limbs; outer parts of the limbs, especially the fingers, turn dark blue, become gangrenous and died altogether; the gangrene rapidly extended over other parts of the body, was not confined to fleshy parts but affected the bone, so that often the gangrenous parts fell off, 61. [960.]
Petechiæ, 62, 64.*
Furuncles, 62.
Bloodboils, 64.
A slight eruption on the skin changing to gangrene, first on the toes and fingers, then rapidly extending over the arms and lower extremities, 64.
Gangrenous blisters, 64.*
Various eruptions on the skin, 47.
Large ecchymoses, 64.*
Blood ulcers, 47.
Eruption of livid spots over the body, 99.
Spots on the face, 34. [970.]
Numerous boils on the back, nates, and abdomen, with cutting pains, surrounded by erysipelatous redness, and becoming gangrenous; this gangrene extended over the whole trunk and thighs, with separation of the epidermis and a cadaverous odor; followed by bloating of the abdomen, hiccough, coma, and death, 144.
Boils on the neck, discharging a yellow matter, with burning pain, 34.
Boils on the neck, 34.
A painless blister on the left index finger, as large as a nut, that opens and discharges ichor; the base of the sore is blackish; all the fingers are insensible, 42.
Spots like fleabites, on the feet, lasting eight weeks, 34.
Subjective.
Pains in the skin, 65.
*Formication, 143, 155, 161.
The whole course of the disease was accompanied by formication of the feet and other symptoms characteristic of ergotismus, 98.
Formication, with a sense as if mice were creeping under the skin, 142.
Formication on the face, gum, and other parts of the body, 70. [980.]
Formication in the extremities, with tearing-stinging pains, 140.
Formication on the arms, legs, and face, 47.*
Formication of the extremities, 162.*
Formication, not only in the fingers, but over the whole body, 42.
Formication in the tips of the fingers, lasting several weeks, with a partial loss of sensibility, 42.*
Crawling and formication over the whole body, 145.*
Crawling all over the body (first day), 155.*
Crawling between the skin and flesh, 140.
Jerking crawling under the skin, 37.
*Sensation as of something creeping under the skin, 70. [990.]
Sensation of crawling becoming greatly increased, so painful that the patient cried aloud and could rest in no position, 64.
Crawling and creeping in the skin, 82.
Violent crawling and prickling over the whole body, especially on the upper lip, and at times all about the mouth, 89.
Crawling and creeping, 76.
Crawling and insensibility extending even into the forearms, 42.
Violent crawling in the hands and feet, 160.
Crawling sensation, as of formication, or as if the limb were stiffened by cold or were asleep, as if it had been insensible and sensation were returning with returning warmth; this is especially noticed in the fingers and toes, or often over the whole body, also on the tongue, which is then painful, 61.
Crawling in the tips of the fingers, hands, neck, and other parts, 48.
Crawling in the hands and feet, 86.
A burning, torpid, prickly sensation over the whole surface, with much difficulty in moving the extremities, accompanied by a sensation like that produced in a limb by pressure on the trunk of a nerve, when we say that the limb is asleep (first day), 156a. [1000.]
Fine stitches, here and there, in the skin, disappearing on scratching, soon returning; the places scratched were affected for a long time by a disagreeable warmth, 109.
Itching all over the body (sixth day); so as to cause the patient to tear her skin (eighth day), 155.
Distressing itching on the lower extremities, like formication, 34.

SLEEP

Drowsiness and inclination to sopor (fourth day), 155.
Drowsiness (sixth, eighth, and ninth days), 155.
Strong desire to sleep (after one hour); the sleep the following night was disturbed by anxious dreams, 124.
Great sleepiness, 72, 84.
Sleepiness, 64.
Great inclination to sleep, 72.
Inclination to sopor (first day), 155. [1010.]
Stupefied slumber, for days, 47.
Deep and long-continued sleep, 72.
Almost complete sleep (in one hour), 167.
*Somnolency, 162.
Slept an hour and a half in the night, the first she had enjoyed during her illness (second night), 155.
Sleep restless, interrupted by anxious dreams, 64.
Passed a restless, feverish, and sleepless night, in a state of great nervous agitation, 156.
Sleep very restless, 12.
Sleep restless, with heavy dreams, 80.
Little sleep (first night), 126a. [1020.]
Sudden waking from sleep, with a wild staring look (tenth day), 155.
Sudden waking from sleep and looking wild, as if frightened, followed by palpitation of the heart (ninth day), 155.
Entire absence of sleep (second and third days), 156a.

FEVER

Chilliness.
Extremely violent chill, followed by burning heat, especially affecting internal parts, and associated with violent anxiety, so that many lose their reason, with violent, almost unquenchable thirst, 61.
Violent chill, followed by violent burning heat, with unquenchable thirst, 64.
A chill came on, followed immediately by nausea, sharp pain in the head, with dizziness and partial blindness, 156.
Rigors, with cutis anserina, 125.
Rigors, followed by heat and violent thirst (first day), 155.
Shaking chill, 48.
Creeping chill over the extremities (after one hour); chilliness over the whole body (after three hours), 126. [1030.]
General sensation of coldness in different parts of the body, as from cold water or from snow, 89.
Sensation of cold (after one hour), 126a.
Coldness of the surface of the body, and particularly the extremities, 157.*
Diminished temperature of the body, 147.*
*Cold skin, 122 ; (after three-quarters of an hour), 106.
Skin cold, particularly that of the face, 108.*
Temperature of skin low, with free perspiration (after two hours), 104.
Skin cool, 87.
Shivering, 122, 148.
Sudden shuddering, 48. [1040.]
Face cold and pale, 153.
Shivering in the limbs (after one hour), 123.
Temperature beneath tongue 98° Fahr., 131.
Sensation of great coldness over the back and abdomen, 64.
Heat.
Fever (first night and second day), 156.
Fever accompanies the pains in the stomach and abdomen, and pains in the limbs with internal heat, anxiety, and great thirst, 100.
Febrile excitement, 47, 54, 64.
Typhoid symptoms presented themselves (first day), 155.
Intense heat, 149.
Increased heat of body, 81. [1050.]
Heat, 64, 76.
Heat with thirst, 48.
Burning hot skin, 100.
Heat and dulness of the head, 100.
Sweat.
Profuse general perspiration, 146.
Perspiration all over the body except the face (sixth day), 155.
General sweat, relieving all the symptoms, 147.
Very profuse general perspiration, 34.
Breaking out of cold sweat, 63.
Covered with cold sweat, 142.* [1060.]
Clammy sweat, followed by epileptiform spasms and death, 139.
Cold clammy sweat, 64.*
Profuse cold sweat, 160.*
Sweat on the forehead, 148.
Sweat from the head to the pit of the stomach, 80.
Limbs covered with cold sweat, 97.

CONDITIONS

Aggravation.
( Forenoon ), Spasms.
( Evening ), Pressure and dragging in hypogastrium.
( Night ), Spasms; pain in flesh.
( After eating bread ), Vertigo.
( Heat ), Pains.
( On appearance of menses ), The symptoms.
( During micturition ), Burning in urethra.
( On moving ), Dizziness of head; in bed, dizziness of vision.
( Moving head ), Black before eyes.
( When rising ), Dizziness of vision.
( Rising up in bed ), Black before eyes.
( On attempting to urinate ), Cutting and smarting in urethra.
( Warm air ), Prickling in stomach; pains.
( Warmth of bed ), Pains.
Amelioration.
( Open air ), Prickling in stomach.
( Extending flexed parts ), Pain in arm and hand.
( Stooping ), Pain in back.
( Sweat ), The symptoms.

Secale Cornutum