Ammonium bromatum

Volume I — Main text

Ammonimn bromatnm, bromide of ammonium, NH.Br. I. Provings. — i. A. M. Gushing, M.D., Feb. 20th, 1808., 7 a.m., took 5 gr. of ix trit, ; 9 a.m., 5 gr. ; 12 m., 5 gr. ; 8.15 p.m., 5 r. ; 10 p.m., 10 gr. 21st. — A sudden short cough when rising from cd in m., from sensation of mucus in throat. 7 30 a.m., took 10 gr. ; it is a warm morning, and in the house I am troubled more with cold than I have been at any time during the winter ; have to warm my feet even in a warm room. 10 a.m., biting sensation on 1. side of tip of tongue. I p.m., stringy, tasteless mucus in mouth. 2.15 p.m., took 10 gr. ; 8 p.m., 10 gr. ; 10.4S p.m., \o gr. 22nd. — 7.30 a.m., 10 gr. ; feet cold J 9 p.m., 10 gr. ; 10.30 p.m., 20 gr. j at times during d. felt as if band were tied around head above ears. 23rd. — 8.30 a.m., 15 gr. ; feet very cold, head feels tied as before, pressing hardest just above ears ; 3 p.m., 10 gr. At II a.m. and 3 p.m., a sharp, twisting pain just above crest of ih'um, r. side; e., feet cold 5 10 p.m., 15 gr. ; sudden cough \ the cough and inclination to cough come suddenly. 24th,

8 a.m., 20 gr. ; 3.30 p.m., 10 gr. } 1 1 p»m., 20 gr, ; during e. suddeti, hacking cough, with watery discharge from the nose; 12.30 a.m.,20gT. 25ih., 8 a.m., 20 gr* ; feet cold, legs ache, accumulation of mucus in posterior fauces ; fauces and top of tongue fur half Its length feci as if thev had been scalded ; accumulation of mucus in fauces, stinging in fauces^ with inclination to cough, but relieved by sneering i feet cgid ^ repeated sharp pains in baclc of r. leg, midway from hip to knee ; urn., 20 gr. ; in 20 m. sudden urgent desire for stool, with loose stool. 26th. — Tickling in throat in m.,with inclination to cough j tongue very sort as if burnt j cannot talk or read without pain ; mouth filled withsalisa ; tickling in throat j 1 145 p.m., 20 gr. 27th. — Tongue stiff and sore ; irritation of throat with inclination to cough ; tongue sore all d. ; some pain in posterior of J. leg, midway from hip to knee ; tighrness across chest with pain in lungs ; inclination to draw long breath ^ 12 m., when walking, had to hold mouth open on account of heat in throat and lungs. 28th. — In m. tongue dry, sore, and stiff. 9 a.m., 20 gr. ; irritation of fauces with desire to cough 5 stomach feels bad ; food does not digest, can taste it several h. ; pain in left leg gone, but is in same localityof r. leg; an old harmorrhoidaJ tumour which had not appeared for some time returned, and was quite hard, sore, and very small, but soon disappeared. 29th. — In m., tongue smarts severely, as if just burnt; inclination to cough (rom low down in the throat ; distress ^ sore^ lame feeling in the stomach ; white, thick, mucus in throat ; sudden, deep cough ; swallowing anything cold causes distress entire length of ocso* phagus and into stomach ; flashes of heat over body^ as if perspiration would come on. ii p.m., terrible distress in upper part of epigastrium j could not sit still, — had to walk the room ; during this time much belching of wind ; pain went through to back and extended to both hypochondrta ; could scarcely get breath ; pain was so severe that it produced perspiration over whole body ; took a dose of cuprum met., which wholly relieved pain in 4 h. March 1st. — In m., mouth fcch as if just burnt ; tickling on both sides of throat, causing deep cough ; distress in stomach. 8 p.m., something seems to rise from pit of stomach, almost stopping breath, causes faint and very disagreeable sensation, partially relieved by raising wind, tasting of food eaten several h, before j bcaid feels a!> if band were around it, 2nd. — In m.j mouth feels as if justburnt ; stomach easier ; sudden inclination to cough, from tickling in both sides of throat just below tonsils. During afternoon and e. seti^tion of fainting or suffocation, beginning at epigastrium and rising on both sides of sternum to the throat, causing him to sigh and walk around the room ; feared he might die j pain under middle ofl. clavicle, above ears ; inclined to be chilly, with flushes of heat ; occasional belching of small quantities of wind, slightly sour ; sensation of hot air pa^s* ing up throatj on r. side, thougli stomach feels cold ; pain around both eyes, into head {took i dose of carbo. veg,J. Back and feet cold in z warm room 1 mouth filled with white, frothy, stringy mucus. 3rd.-^ Mouth feels as if burnt ; while eating, a sensation in stomach similar co that experienced last e. i pain around orbits ; r, eye full of white, stringy mucus ; much redness between orbit and inner canthi \ looks as if 4 membrane were growing over it (pterygium) j sharp pain m K side af

head, near eye; feet cold. 11.30 a.m., feeling over r. kidney as if something were pressed hard against it, relieved by pressure, but leaving a pulling sensation ; sudden cough, from tickling in throat just below tonsils ; stomach feels badly in afternoon, but easier than on previous c. ; eye smarts in e., but not during d. 4th. — R. eye sore ; lids swollen ; eye full of white, stringy mucus. During afternoon and e. cough is deep from tickling in throat as before, causing pain in tonsils. R. eye quite sore ; feels large, and smarts ; have to wear shade in e. to read or write ; sore spot over r. kidney ; feet cold in warm room ; fauces slightly sore. 5th. — Both eyes sore, very red ; lids stuck together in m. ; throat sore ; fauces dark fed and congested ; feet. cold in warn) room ; occasional, sudden cough, with expectoration of white mucus ; throat sore ; tongue feels as if burnt. 6th. — Tongue sore on top, both sides and tip ; throat sore, — looks mottled, as if diphtheritic deposits were commencing ^^ frequent sensations (which occur daily), as if something were rising from stomach, but not like wind^ causing faint sensation, but disappearing in a moment. 10 g.m., sharp, cutting paip in stomach; throat sore, wofse on I. side ; slept but 2. h. last night ; have been in wind all d. ; eyes much better. 7th. — Was out mo5t of the n. (6th), still my eyes and throat are much better, and I coughed less. 8th. — Close application to (>ooks last e. did not cause any feeling of pain in eyes. Throat is well, and no desire to cough. 10 p.m., took 25 gr. 2nd trit. 9th. — In m., pyes red and sore, with white mucus in corners ; 1. eye worse. Throat sore, with expectoration of white, sticky mucus, with similar discharge from hose. 6.3Q a.m. and 2 p.m., took same. During e. tickling in tl^roat. Nose stopped up, then discharge of clear fli|id. 11.15 P-"^*) same dose, ioth. — Eyes feel sore, as if sand were in them ; mucus on eyelashes ; no discharge from nose. II a.m,, tickling in throat, ^ith inclination to cough. During e., tickling in throat ; mostly on sides, causing him to cough suddenly. Throat smarts, nose stopped up ; fauces look red. luh. — In m., mouth feels as if burnt, throat sore ]| sudden cough, then a deep cough ; pain in 1. side of head, pear eye, which occurs daily. In e., eyeballs feel large and sore ; sudden, spasmodic cough from tickling in throat ; pain in both tonsils ; pain in ri^ht lung, lung feels cold inside ; an occasional discbarge of watery fluid from 1. nostril \ peculiar pain in head, cannot describe it. j 1 p.m., took 75 gr. of 2nd. 12th. — Eyes smart ; tongue feels as if burnt, worse near the tip. 3 p.m., r, eye feels as if bathed in hot water. Eyes do not feel any worse from not having slept last n. 13th. — Was called up at ^ a.in. Eyes stuck together ; mouth full of white, sticky mucus ; eyes feel badly to-day, though I was not awake but i^ h. last n. ; during d. sudden inclination to cough from tickling in throat ; pain in head (daily), just back of the eyes, worse on 1. side ; in c. eyes feel very large, with constant blur before them. 14th. — Sharp pain in lungs, worse in upper portion of r. lung ; tickling in throat, with cough ; 10.30 p.m., took 100 gr. of 2nd. 15th. — In m., mouth feels as if badly burnt ; sharp pain in both lungs, and, during forenoon, pain seemed to be mostly in pleurae. All forenoon felt as if cord were tied around r. leg midway between hip and knee, making him limp, causing pain. In afternoon pain in r. leg disappeared, and was

•

felt below knee in 1. leg. In e., it was in ankle, then in 1. foot, soon passing away, with inclination to cough returning. i6th, — Eyes and fauces sore ; mouth feels as if burnt ; expectoration of white^ sticky mucus ; L ankle and foot lame ; almost constant desire to cough ; sense of suffocation from lungs, which causes him to move around from fear of suffocating, 17th. — Frequent constrictive pains and tightness across chest ; frequent cough i very sudden desire to cough, coming so suddenly by tickling in throat, it strangles him and almost arrests breathing ; expectoration of gelatinous mucus. i8th.^ 7 a.m., took 50 gr. 9 p.m., sensation in r. shoulder, as if pressed by a weight. 19th. — Throat filled with white, sticky mucus ; have to hawk it up, causing smarting of fauces, 7 am., took 50 gr of 3rd trit. 20th.^ — Expectoration ot white, sticky mucus j feet very cold in warm room, causing legs to ache. 9 a.m., same dose. In e,, feet cold j throat feels sore ; pain in r. side of head, near eye^ as if nail were driven into it i every e., eyelids droop, and it is difficult and painful to raise them. 10 p,m,, lOo gr. of samelist. — In m., mouth and fauces full of white, sticky mucus. 7 a.m., 25 gr. of same. Throat much irritated. 8 p.m., sharp pain in lower portion of h car, extending to cheek and neck ; throat sore ; preparing to swallow is painful, but act of swallowing is not. 22nd. — In m,, mouth very dry; during d, throat filled with white, sticky mucus^ streaked with blood. 23rd. — ^Expectoration of white, sticky mucus, and occasionally blood, (Trans, if Arjver, Init.^f Hom,y 1870, p. 354),

2, A student took, at 7 p.m,, 40 gr, in 3j of water* In 3I h. he experienced slight excitement of circulation \ tightness at temples ; flushing of face j and prickling sensation in skin. Next d., at 2.45 p.m., took same quantity by enema in mucilage of starch. In 45 m. had some excitement of circulation as before, with slight nervous exaltation such as he has after taking wine, (Clarke and AMORy,Oif Br^midt of Potassium^ Boston, 1872.)

1. Another student took same dose in a claret glass of water on an empty stomach at 10 p.m. Pulse was 80 ; in 15 m. 88 ; tn 30 m. 80 again. In 40 m. vascular excitement and exhilaration as after taking morphine j this gradually decreased, and was lost in a fit of drowsiness ^ after \ h. he found himself nodding, and retired. Towards e. next d. he had uneasiness in bowels ; on following d. decided diarrhoea set in, and lasted 12 h., without griping or distress, though abdomen was distended with flatus. He never had diarhcea, and could see no cause for this attack but the drug. On another occasion, took 20 gr, on a full stomach before retiring \ again, within J h., felt as if he had taken opium ; dreamed of trying to pass urine into a bottle, but being unable to do so on account of being constantly in a crowd of men and women {Ibid.)

Volume IV — Appendix

AMMONIUM BROMATUM.

(See vol. i, p. 603.)

I. 4. Dr. J, C. Morgan took 3X trit. srveral times daily for 3 d. First symptom noticed was feeling of malaise and fatigue, worse on lying down, relieved after emission of flatus while urinating. Tickling in trachea and bronchial tubes, attended by cough and slight scraping in throat while coughing. Sneezing while moving about in a cool room, or on raising arms. Slight thin discharge from r. nostril, next d. this was thicker. Sensitive to cold air. Chilly feeling in back of chest and nape of neck. Increased mucus in pharynx, causing cough. 2nd d., m,, voice changed as from obstructed nose, in a warm room. Walking in damp air, nose smarted as if raw ; worse when inspiring. Later, sneezing. In e, cough, dry and irritating. 3rd d. — Woke at 3 a.ni. with cough, increased by pressure on throat. Increased discharges from bronchi and nose. Mind more active and resolute. Coughed but little during d., and it was loose. In e., difficult vision and hemiopia^ followed by coughing and right-sided headache, which cough

screases. 4th. — Wakened at 3 a.m. with pain from sternum to spine, relieved by changing position. Later, while writing, misspelled 'words and numbers. Persistent disposition to stoppage of nose in a warm room. Felt timid and discouraged, lacked self-confidence. There was considerable malaise and languor, with nervous restlessness. Desire for external warmth and for hot drinks. Pains in legs at intervals, worse from motion. After a fatiguing walk late in e. irregular action of heart. 1 p.m., whistling expiration^ apparently from 1. stril i sticking pains in r. ear. After these symptoms, there occurred lome d. frequent attacks of colicky pain in lower abdomen ; also thick discharge from nose.

During latter part of proving there was an irritable feeling under finger.nails, relieved only by biting them ; hence this was frequently done. [Trans, of Amer. Imt, of Horn. ^ '890, p. 225.)

1. About 100 healthy persons, male and female, of various ages,

were given doses of the salt, ranging from i to 5 gr.j 3 times or more

id,, in water. The period of its continuance varied from 3 weeks to

several months, and the results were carefully noted. In the greater

lumber there was increase in appetite and improvement of complexion ;

they ate more food, and were able to digest it well — the drug seeming

'o impart a soothing and comfortable sensation. The action of the

oowcls was perfectly natural. The circulation was entirely unaffected.

'n 6 or 7 cases a mild diuretic effect was observed. If the small doses

^*^re continued for some time, these ef)^'ects were not always continued,

And in a few persons slight nausea was produced, with impairment of

'Ppctite; this was especially so when 4 — 5 gr. doses were g^ven. In

3 Only was there a little headache, with giddiness and lightness of head,

put the intellectual faculties were unimpaired, Coincidently with

'^crrease of appetite was a marked cleaning of the complexion, espe-

i?^^lly observable if the face was naturally florid or the skin very red.

•* His redness or flortdity became decidedJy paler, and the skin assumed

_^ne transparent freshness indicative of healthy function. Dinginess,

''^ht sallowness, or a heightened complexion became modified or

^*,^«red, so that a more healthy, slightly pink colour was assumed.

I~ ^ese effects were noticed sometimes when the salt had been taken

y^ ^>*t a few d., and the improvement in the sk<n was so apparent that it

^^« attracted notice. (Gibb, Tram, of Brit. Jtsoc.y i^b%.)