Propylaminum

Volume IV — Main text

TRIMETHYLAMINUM.

An alkaloid found in several plants, .is Ckevcpadium <vulvaria and ArmeSl also in such fluids as herring-brine, from which the commercial T. (k " propylamine ") is most frequently obtained. Its formula is C,H,N.

I. Proving!, — I. Dujardin-Beaumetz took 50 centigr. chloride of T. in water. Pulse before experiment was 78 ; it was 76 ; after i ^ h. 74 ; after 2 h. 72 j after + h. 78 again.

374 (centigrade) before experiment, fell to 372 after 1 h., 37 after '^\ h-, 36*8 after 2 h. (Allen's Encyclopadiay x, 25.)

1. Another person in perfect health took 75 centigr. of same. Pulse, 88 before experiment, was 84 after i h., 82 after i^ h,, 76 after 3 h. Diminished force of heart's action was also shown in

acing talcen. Temp., 37" before experiment, was 36'8° after I h., V4- after i \ ^,, 36° after 2 h. {Ibid.)

1. I cook 10 dr. in water. In ^ h. I experienced a smarting QMCion of tongue and fauces, with much thirst \ there was also a

tingling of the fingers, a sensation of numbness to such an extent that 'm attempting to pick up anything it felt heavy, and I had to use great effort to retain the article within my grasp. This group of symptoms paised off after 3 h. I then took anottier 10 dr., and experienced the ibove symptoms intensified, with the addition of great pain in wristjoi^t^ also great restlessness, yet inability to stand upon my feet from the pain produced in the ankle-joints. I took no more of the medicine, but the tongue became broad and flabby, the mucous membrane of the buccal cavity was pale, appetite gone, no desire for anything ; I became morose, with great desire to be let alone. The pain in the joints was made worse by the slightest movement. In 24 h. after taking the drug 1 was attacked with diarrhoea; stools were thin, watery^ and white. (Chaffee, U. States Med. Invest., June 15th, 1880.)