Formula , CHCl3.

Preparation , for internal administration, solutions in alcohol.

Authorities.

1 , Lembke, provings with repeated doses of 1 to 22 drops, A. H. Z., 39; p. 369; 2 , Dr. Board, effects of 4 ounces internally, Br. Med. J., 1866; 3 , Dr. Busey, effects of a teaspoonful internally, Am. J. of Med. Sc., Oct. 1872; 4 , Chereau, effects of 37 1/2 drachms, Med. Times and Gaz., 1857; 5 , Dowling, effects of 1 1/2 ounces, B. and F. Med.-Chir. Rev., July, 1864; 6 , Dunereicher, effects of inhalation, Lond. Ed. M. J. of M. Sc., 19, 372; 7 , Fricke, effects of a tablespoonful internally, Phil. Med. Times, May, 1871; 8 , Haffoldt, chronic effects of habitual inhalation by an asthmatic patient, L'Art Méd., 6, 378; 9 , Hammond, inhalation, fatal, Med. T. and Gaz., 17, 174, n. s.; 10 , Lamm, fatal case of drinking considerable for sleeplessness, A. H. Z. (M. B.), 5, 42; 11 , Langenbeck, inhalation, Deutsche Klin., 48; 12 , Mackei, effect of 12 1/2 drachms internally, Union. Med., 1864; 13 , Richet, fatal inhalation, Med Times and Gaz., 18, 142; 14 , C. H. Smith, 2 ounces internally, Am. J. M. Sc., Oct. 1857; 15 , Spence, 2 ounces internally, Lancet, Aug. 1856; 16 , Yvonneau, general effects, Hirschel's Archiv., 1, 158; 17 , Holmes, effects of 3 1/2 ounces, Assoc. Journ., 1856; 18 , Journ. de Toul., 1857, a woman swallowed 2 ounces; 19 , Pringle, effects of 2 ounces internally, Lancet, 1856; 20 , Robert, Gaz. des Hôp, 1853; 21 , Santesson, inhalation, Hygeia, 2, 599; 22 , effects of inhaling for extraction of tooth, All. Med. Zeit. (from Am. Obs., 7, 528); 23 , Berridge, effects of inhalation, M. H. Rev., 16, 38.

MIND

Emotional.
Wild excitement, followed by complete insensibility, 17.
On waking from its effects she felt almost tipsy, frequently laughing, and not understanding what she said or did, 23.
Laughed and talked; told how the medicine burnt her tongue and hurt her (after half an hour), 3.
Talked nonsense, but spoke grammatically, 23.
In two provers obscene language was used under its influence, 23.
In two cases they sung comic songs, and one addressed the surgeon in a most familiar manner, 23.
Afterwards she could scarcely be persuaded to leave the piano, of which she was very fond; she would have continued playing all night if permitted; she could scarcely be persuaded to go to bed, 23.
Intellectual.
Seemed scarcely to understand anything said to him, and kept on muttering, 2.
The patient pronounced some incoherent words, and sought to get away from the chloroform, 13. [10.]
Insensible, still continuing to vomit (soon after), 12.
Could not be roused from insensibility (after ten minutes), 14.
Remained unconscious for ten hours, and felt no uneasiness on awaking, 8.
Entirely unconscious (after eight minutes), 7.
Lying in a state of perfect unconsciousness (apparently in a profound sleep), from which she could not be roused (after twenty minutes), 15.
Complete unconsciousness, 19.
Utter loss of consciousness, 12.

HEAD

Vertigo.
Sensation of vertigo rising from the spine into the occiput (fourth day), 1.
Vertigo, 16.
Dizziness, 7. [20.]
Whirling of the head; sensation as if he would fall forward (second day), 1.
Sensation as if the ground were waving, on closing the eyes (third day), 1.
General Head.
Empty feeling in the head (fourth day), 1.
The head is light, with a peculiar sensation of clearness (first day), 1.
Heaviness of the head (fourth and fifth days), 1.
Heaviness in the head and pain in the forehead (sixth day), 1.
Felt a rush of something to the head, 7.
Headache, 16.
Violent headache (after sixteen hours), 16.
Pressure in various places in the brain (fifth day), 1. [30.]
Pressure in various parts of the brain (sixth day), 1.
Temples.
Pressing in the temples (fifth day), 1.
Pressure upon the temples (second day), 1.
Occiput.
Heaviness of the occiput (fourth day), 1.
Heaviness in the occiput, with vertigo (fifth day), 1.

EYE

Lids.
Inclination to close the eyes (fourth day), 1.
Eyes closed involuntarily (fifth day), 1.
The eyes close in spite of one (fourth day), 1.
Lachrymal Apparatus.
Moisture of the eyes (third day), 1.
Moisture, almost lachrymation of the eyes (third day), 1.
Conjunctiva. [40.]
Conjunctivæ injected, 13.
Conjunctiva quite insensible (after twenty minutes), 15.
Ball.
The eyes were suddenly turned up, 9.
Eyes fixed towards upper and inner angle, 5.
Pupil.
Pupils dilated (third day), 1.
Pupils dilated (just before death), 20.
Pupils dilated and insensible, 5, 11, 16.
Pupils widely dilated and insensible, 4.
Pupils very much dilated, 2.
Pupils enormously dilated, 12. [50.]
Pupils very large (third day), 1.
Pupils contracted (second day), 1.
Pupils at first contracted (soon), (fifth day), 1.
Pupils very much contracted (after twenty minutes), 15.
Pupils greatly contracted, 18, 19.
Pupils variable, now dilated, now contracted, 17.
Pupils during narcosis dilated; afterward, before death, contracted, 10.
Vision.
Everything seemed more distinct than usual (immediately), 1.
Dimness before the eyes (sixth day), 1.
Darkness before the eyes (fourth day), 1. [60.]

EAR

Ears seemed stopped with cotton (fifth day), 1.
Ringing in the ears (fifth day), 1, 16.
Roaring in the ears (sixth day), 1.
Roaring in the ears like boiling water (fifth day), 1.

NOSE

Objective.
Nostrils obstructed by swelling of the mucous membrane, 8.
Bleeding from the left nostril a teaspoonful of dark blood; if afterwards bleeds easily (fifth day), 1.
Smell.
Sense of smell is weaker than usual (third day), 1. [80.]
Entire loss of smell (lasted two months), 8.

FACE

Cadaverous countenance, 4, 12.
Expression that of a person partially intoxicated (after half an hour), 3.
Some flushing of the face, 9.
Face flushed, 13.
Face livid, 6 ; (after two hours), 11, 19.
Face became turgid, 9.
Trismus, 6.

MOUTH

Teeth.
Teeth smooth, as after acids (fourth day), 1.
Tongue.
Tongue pale, 8. [90.]
Tongue covered with frothy saliva (third day), 1.
Tongue dry and parchment-like, 4.
General Mouth.
Mouth half open, 4.
Mucous membrane of mouth and throat flaccid and swollen, 8.
Foamed at the mouth, 6.
Complained of the burning sensation the dose produced (immediately), 7.
Complained of the pungency of the medicine, 3.
Saliva.
Much saliva (second day), 1.
Thin saliva (fourth day), 1.
Taste.
Soapy taste in the mouth (third day), 1. [100.]
Altered taste of all food and drink, especially coffee (lasted two months), 8.
Sense of taste abolished, 8.
Speech.
Could hardly articulate, 2.

THROAT

Jugular veins distended, 4, 11.
Scraping and dryness in the throat (second day), 1.
Prickling sticking in the throat, especially on swallowing (soon), (second day), 1.
Fauces.
Fauces very red, with scraping in them (fourth day), 1.
Violent burning in the fauces and heat in the stomach (immediately after 20 drops), (sixth day), 1.
Scraping in the fauces (third day), 1.
Violent scraping and coldness in the fauces, on inspiration (fifth day), (soon after taking), 1.
Swallowing. [110.]
Deglutition interrupted, slow, and difficult, 3.

STOMACH

Thirst.
Thirst (second day), 18.
Great thirst at first, 11.
Eructation and Hiccough.
Eructations tasting ethereal, 1.
Frequent eructations smelling strongly of chloroform, and causing prickling in the nose (fourth day), 1.
Constant hiccough, 17.
Nausea and Vomiting.
Nausea (sixth day), 1 ; (second day), 18.
Nausea, with much saliva (fifth day), 1.
Urging to vomit (fifth day), 1.
Vomiting, 9. [120.]
Vomiting (soon after), 12, 14.
Violent vomiting, 17.
Stomach.
Pain in the epigastrium (during convalescence), 19.
Severe pain about region of stomach and spleen, 5.
Burning in stomach, 3.
Burning in the stomach alternating with chilliness (fifth day), 1.
Pressure in the stomach (third day), 1.
Pressure in the stomach, increased by external pressure (third day), 1.
Pressure in the stomach, with nausea (fifth day), 1.
Dull pressure in the stomach (third day), 1.

ABDOMEN

Objective. [130.]
Abdomen tense (before death), 10.
Rumbling, with passage of flatus (fifth day), 1.
Rumbling in the abdomen (fourth day), 1.
Rumbling in the abdomen, with passage of flatus (third day), 1.
Much rumbling in the abdomen, with warmth (third day), 1.
Passage of much flatus (third day), 1.
Abdomen painful (second day), 18.
Cuttings deep from the stomach to the navel (second day), 1.

RECTUM AND ANUS

Although the rectum and intestines were as torpid as the genital organs, yet the sphincter ani preserved its contractility, 8.

STOOL

Diarrhœa.
Bloody diarrhœa (during convalescence), 19. [140.]
On two occasions, I have noticed involuntary discharge of fæces, 23.
Much blood in the stools (second day), 18.
Constipation.
Constipation sometimes lasted eight days, but without giving rise to uneasiness, 8.
The torpidity of the large intestine was such that he was obliged to resort continually to cathartics, 8.

URINARY ORGANS

Urethra.
Emission of urine painless, but accompanied with a curious sensation along the urethra, 8.
Stitches in the urethra (fifth day), 1.
Voluptuous tickling at the orifice of the urethra, with erections and desire to urinate (fourth day), 1.
Much desire to urinate (fourth day), 1.
Micturition.
Urine increased in quantity (third and fourth day), 1.
Bladder distended, and bedclothes stained by urine that had escaped, 4. [150.]
When the bladder was distended, the urine was only expelled after much effort, 8.
Urine suppressed, 10.
Urine.
Urine dark yellow (fourth day), 1.
Specific gravity of urine rather lower than normal; it contained a large proportion of triple phosphates, and traces of uric acid crystals, 8.

SEXUAL ORGANS

Genitals as if much shrivelled (third day), 1.
On one occasion erection of the penis occurred, 23.
No erections for two months, 8.
Sexual desire, with a peculiar feeling in the testicles, which made him believe that the spermatic secretion still continued, and that the impotence was owing to paralysis of the perineal muscles, 8.
Sexual appetite wanting, and the generative functions in a languid state, for several weeks, 8.

RESPIRATORY ORGANS

Tracheal râle, 12.
He spoke in an altered drawling voice, 23. [160.]
Loss of power of speech; could not utter any sound whatever; remained in that state for five weeks, after which she began to speak in a low tone, 22.
Respiration stertorous, 12 ; (after ten minutes), 14, 16.
Breath smelt of chloroform, 5.
Short, quick, irregular, and superficial breathing, 3.
Breathing slow and stertorous, 5.
Respiration became very slow (2), and stertorous, 19.
Respiration very slow and deep (sixth day), 1.
Respiration became very slow, full, and deep, 21.
Respiration very slow and difficult, 11.
Respiration very slow, with plainly perceptible beating of the heart internally (fourth day), 1. [170.]
Respiration 15 (usually 22), (soon), (sixth day), 1.
Respiration fell to two in a minute, 18.
Deep, slow respiration (after one hour); respiration very slow, fifteen to the minute, superficial, with at times deep inspiration (after one hour and a quarter), (fifth day), 1.
Frequent deep breathing (fifth day), 1.
Respiration during narcosis feeble and slow, afterward before death it became rapid, deep, and rattling, 10.
Irregular respirations, 6.
Respirations sometimes irregular and short, at others deeper and separated by longer intervals, 4.
Some oppression of breathing, 5.
Respiration appears embarrassed, 5.
Respiration arrested every now and then, 12. [180.]
Eight or ten inspirations were distinctly remarked after the complete and entire cessation of the cardiac movements, 13.

CHEST

Slow, but regular, heaving of the chest, with some subsultus of the muscles, 4.
Moist crepitation over lungs, 5.
Tension in the chest and bruised feelings in the joints (fourth day), 1.
Oppression of the chest, with slow respiration for a long time (fifth day), 1.
Sternum.
Pain in the right margin of the sternum, deeply seated (fourth day), 1.
Pressure behind the sternum (fifth day), 1.

HEART AND PULSE

Præcordium.
Pressure on the heart (sixth day), 1.
Stitches in the region of the heart and upper half of the left lung (sixth day), 1.
Internal pulsation of the heart, like a trembling, rather more while sitting, with oppression of the chest, nearly the whole day (fifth day), 1.
Heart's Action. [190.]
Action of heart occasionally tumultuous, 12.
Beating of the heart powerful, rapid, felt through the whole chest into the arms, and moving the book held in the right hand (first day), 1.
Beating of the heart felt in the chest without being noticed in the hand (fourth day), 1.
Heart beat so feebly that it required sustained attention to perceive its weak and rare contractions, 4.
Heart-sounds feeble, 5.
Pulse.
Pulse frequent and undulating, 6.
Pulse rapid and weak, 17.
Pulse more rapid than usual (immediately), 1.
Pulse at first increased, afterwards small and indistinct, 11.
Pulse 78, soft and tolerably full (after twenty minutes), 15. [200.]
Pulse 100 and feeble; afterwards insensible, 12.
Pulse 100 to 120, soft (second day), 18.
Pulse slower than normal (at first), 21.
Pulse became slower, and suddenly stopped, 21.
Pulse 64, usually 75 (third day), 1.
Pulse about 60 (after ten minutes), 14.
Pulse 60 (after half an hour), (fourth day), 1.
Pulse 56 (after one hour), (fourth day), 1.
Pulse 50, very weak, 16.
Pulse weak and slow, afterwards, just before death, it became full and strong; then rapid (160), and weak, 10. [210.]
Pulse 95 (after ten minutes); 65 (after half an hour); 70 (after three-quarters of an hour); 54 (after one hour and a quarter); 66 (after two hours and a half), .

NECK AND BACK

Veins of neck swollen, 13.
Dull pains in the region of the kidneys (second day), 18.

EXTREMITIES IN GENERAL

Objective.
During commencing anæsthesia, twitching of the muscles of the extremities, especially of the arms, 21.
Cracking in the joints and loss of power in them, on moving (fifth day), 1.
Excessive weakness in the limbs (fourth day), 1.
Complete resolution of the limbs, 12.
Subjective.
Compressed sensation in the right ankle and left elbow (second day), 1.
Bruised pain in the shoulder and ankle-joints (third day), 1.
Feels very much bruised in all the limbs (sixth day), 1.

SUPERIOR EXTREMITIES. [230.]

Bruised sensation in the arms (fifth day), 1.
Forearm.
Pressing pain in the muscles of the right forearm and in the flesh above the hollow of the right knee (second day), 1.
Hand.
Peculiar unsteadiness of the hands, with sensation of prostration (second day), 1.
Fingers.
Finger-nails blue (fourth day), 1.
Fingers convulsively pressed against the palms of the hands, leaving impressions of the nails, 4.

INFERIOR EXTREMITIES

Staggered in walking (after half an hour), 3.
Constant painful weakness in the whole left leg, especially the lower leg and calf (first day), 1.
Great weakness in the feet (fifth day), 1.

GENERALITIES

Objective.
Great nervous excitement, 16.
The muscles stiffened, 13. [240.]
Muscles become relaxed, 9.
Frequent stretching and yawning (fifth day), 1.
Very feeble, 7.
Every exertion of the muscles fatigues very soon (third day), 1.
Restless and tossing about before death, 10.
Subjective.
Anæsthesia, with muscular resolution, 13.
Absolute general anæsthesia, 12.
Complete loss of sensibility and recognition, but not of self-consciousness. (Hirschell), 11.
Sense of touch perverted, 8.
When under its influence, felt extremely comfortable; could have remained as she was forever, 23.
She felt as if floating on wings, 23. [250.]
Excessive weariness in all the joints, especially the ankles (third day), 1.
Sensation as if the seat were tottering (fifth day), 1.
While sitting, a sensation as if the chair and table were moving in different directions (third day), 1.
Felt queer twitchings in her body, which lasted over twenty-four hours, 7.
Felt as if hammers were beating all over her, 23.

SKIN

Skin very blue, with coldness of the eyes (fourth day), 1.
Tingling of the limbs, 7.
Crawling in the left fingers (first day), 1.

SLEEP AND DREAMS

Yawning (fourth day), 1.
Much yawning and closing of the eyes, even while walking (sixth day), 1. [260.]
Excessive yawning, as though he would dislocate the jaw (third day), 1.
Great sleepiness and much yawning (fourth day), 1.
A very agreeable sensation of sleepiness, with a very quiet mood (fourth day), 1.
Very sleepy, with chilliness and cold extremities (sixth day), 1.
Much sleep (fourth day), 1.
Apparently deep unconscious sleep, from which she could not be awakened, 18.
Comatose sleep, 16.
After vomiting had been induced, sank quickly and suddenly into a profound and alarming coma, characterized by excessive pallor of the features, sunken eyes, contracted pupils, insensibility of the cornea, perfect and universal muscular relaxation, complete anæsthesia, coldness of the extremities, 3.

FEVER

Chilliness.
Skin cold, pale, 16.
Cold skin, especially on the extremities, with chilliness in the back, during the whole proving, 1. [270.]
Surface of body cold and clammy, 5.
Constant chilliness, with cold extremities (third day), 1.
Internal chilliness (fourth day), 1.
Much internal chilliness, with cold skin (fifth day), 1.
Very cold, 2.
Temperature during narcosis diminished, but before death increased, 10.
Chilliness deep in the back, extending to the temples (sixth day), 1.
Great coldness in the innermost portion of the spine, with coldness and paleness (after one hour and a half), (fourth day), 1.
Extremities cool, 11.
Heat.
Feverish excitement (after sixteen hours), 16. [280.]
Heat in the head (sixth day), 1.
Head hot, 11.
Heat in the occiput (fifth day), 1.
Warmth in the stomach (fourth day), 1.
Sensation of warmth in the bronchi that increases to a biting-burning, with a very troublesome constriction of the larynx, and with difficult interrupted sighing respiration, even amounting to a suffocative anxiety, 16.
Sweat.
Sweat copious before death, 10.

CONDITIONS

Aggravation.
( On closing eyes ), Sensation in head.
( On inspiration ), Scraping, etc., in fauces.
( External pressure ), Pressure in stomach.
( Sitting ), Pulsation of heart.
Amelioration.
( Brandy ), The symptoms.

CHLOROFORMUM.