[Symptoms taken from patients have been selected with care, and only when clearly the effect of the drug. Cases have been selected with a view of furnishing a complete account of the action of the drug; many cases that added nothing new and only increased the bulk of the matter, have been omitted here as elsewhere.]

Potassium iodide.

Preparation , Triturations.

Authorities.

1 , Symptoms from Hartlaub and Trinks, Mat. Med., 3, 37; 2 , Houat, "Pathogenesis nouvelles Données de Mat. Méd.," etc.; 3 , effects of salve, consisting of 1 drachm to 1/2 ounce of fat, rubbed on a small goitre for a long time, in a girl 10 years old; 4 , Dessaiques, a young woman took 1 1/2 drachms in solution, J. de Chim. Méd., 1828; 5 , Bost. Med. and Surg. Journ., 1838, effects of an overdose; 6 , Horst, Hufel. Journ., 1843 (Frank's Mag., 2, 763), a man aged 40, "with constriction and induration of bowels," experienced symptoms in a few minutes after every spoonful of a solution of 1/2 drachm in 6 ounces of water; 7 , Dr. J. Adair Lawrie, effects of 7 1/2 grains in three doses (could take no more) in secondary syphilis, Lond. Med. Gaz., July, 1840; 8 , Bain, effect of long-continued use, Bost. Med. and Surg. J., 11, p. 320; 9 , Dr. Carson, effects of 3 grains three times a day, Lond. Med. Gaz., 1840; 10 , characteristic effects in syphilitic patients, Ricord, Bull. de Thér., Sept. 1843; 11 , characteristic effects in patients, Laroche, Ann. de Thérap., 1844; 12 , effects of four or five doses of a solution of 12 grains in half pint of sarsaparilla, in chronic articular rheumatism, Dr. Lord, Bost. Med. and S. Journ., 1847; 13 , effects of six weeks' use of drug administered for hypertrophy of cervix uteri, in a nursing woman, Dr. Cullier, Br. and Fr. Med.-Chir. Rev., 1848; 14 , characteristic action in syphilitic patients, Drs. de Lowry and Costilhes, Gaz. Méd. de Paris, 1848; 15 , same reference, fatal effect of doses gradually increasing from 3/4 to 15 grains, Dr. Biechy; , effects "in usu morbis," Dr. Flagg, Charleston Med. J., 1848; , effects in chronic rheumatism, Dr. O'Reilly, N. Y. Journ. of Med., 1854; , same reference, effects in chronic rheumatism (patient had formerly suffered from syphilis treated with ); , effects of 8 grains, three times a day, in rheumatism, Dr. Phillips, Bost. M. and S. J., 1853; , general effects, Wood, N. Am. J. of Hom., 1856; , effects of 10 grains, two or three times a day, for 10 years, Dr. Parker, Edin. Month. Med. J., 1852, from B. J. of Hom., 11, 681; , effects of large continued doses in "venereal taint," same as last; , effects of 6th dilution in water, night and morning, Robinson, B. J. of Hom., 25, p. 324; , effects of 1/2 grain doses, every two or three hours, in acute hydrocephalus, Dr. Fluder, Bost. M. and S. J., 27, p. 216 , experiment on Mr. Rosenthal, with 4 grains to 1 drachm daily, Prof. Schneider, Wien. Med. Halle, 1862 (from Syd. Soc. Yr. Book, 1862); , effects of 10 and 12 grains in a case of gastralgia, Dr. Mecklenburg, N. Z. F. H. Kl, 12, p. 8; , effects of four doses, of 9 grains each, in lumbago, otherwise in good health, Dr. Orth, Nass. Med. Jhrb, 15-16, p. 747 (Syd. Soc. Yr. Book, 1861); , effects of a spoonful, morning and evening, for a week, of a solution of 2 scruples in 4 ounces of water, A. H. Z., 45, p. 64; , effects of a spoonful, morning and evening, of a solution of 4 grains to 4 ounces, in a girl with goitre, from same as last; , effects of using Kali iodatum, triturated with the salt used for seasoning food, in proportion of 1 to 1000, for patients with goitre, two ladies over 60, and a gentleman of 45, Rilliet, l'Art. Méd. and U. S. J. of Hom., 1860; , same man as last passed several weeks at the seashore, had return of former symptoms, and developed others; , a lady at seashore suffered from Iod. in air or in the salt, same source as last; , effects in young woman with chronic rheumatism, Dr. Cartwright, M. Hom. Rev., 12, 411; , same, effects in young lady with amenorrhœa; , same, effects in a man; , a woman with pelvic abscess was twice obliged to suspend the drug on account of "Iodism," Dr. Ferrand then applied a shirt dipped in a solution and dried, changed after three days, producing symptoms, Ed. Med. J., 1869, p. 468 (from Bull. Gén. de Thérap.); , effects of drug (with other alkalies) in a man with light-colored stools (5 grains three times a day), Lancet, 1867, Dr. J. B. Curzeman (when the iodide was omitted and the other alkalies continued the bad effects disappeared); , effects of a single dose in the daughter of the previous lady; , effects of 3 grains, three times a day, for enlarged testis, Dr. Roods, Lancet, 1860, p. 479; , same, effects on another, similar case; , case, effects in ovarian dropsy; , same, effects of 1-grain doses in a daughter of last; , same, effects of a 5-grain dose in facial neuralgia (which it removed); , same, effects on self for a rheumatic affection of acromio-clavicular joint, 3- to 5-grain doses; , same, general effects; , general effects, Tilbury Fox., Lancet, 1867, p. 455; , effects in a patient, Dr. Hodges, Lancet, 1865; , same, effects in amenorrhœa; , proving with 15 1/2 grains daily, Rabuteau, Practitioner, 1869, p. 188 (from Centralblatt); , general effects, Dr. Casey, Bost. M. and S. J., 32, p. 41; , ; , effects of 28 centrigrammes daily, six times, in a lady for sleepiness and anorexia, Dr. Maunoir, from Rilliet, Mémoire sur l'Iodism, 1860; , Gautier, from Rilliet, poisoning of a many by 6 or 7 centigrammes, in less than five days, taken for goitre; , D'Espine, from Rilliet, effects of 12 1/2 centigrammes, in sixteen days, for goitre; , Rilliet, effects of 60 centrigrammes, in four months, in a lady with goitre; , same, effects of 90 pills, each containing 2 milligrammes, in a woman; , same, tox. of a man aged 45, by sea-salt (20 centigrammes of Kali iodatum); , same, tox. of woman aged 55, by three weeks' use of "Challes" water (containing Kali iodatum 1 centigramme to 1 litre); , effects of large doses in case supposed to have old syphilitic taint, Dr. Lomon, Gaz. Méd. de Paris, 1875; , proving with one dose of 15 grains, Dr. Colby, by Dr. J. Heber Smith, N. E. Med. Gaz., 1872, p. 25.

MIND

Emotional.
Half mad all night (after first dose), 37.
Troublesome and unreasonable mental impressions, easily strengthened into fixed ideas, 55.
She is very talkative and quarrelsome (after twelve days), 1.
Weeping from the slightest cause, 54.
Sadness, 55.*
Inclined to sadness and weeping, 51.
Depression, 55.
Anxiety, 6.*
Very easily frightened, 2. [10.]
She is frightened at every trifle (after five days), 1.
Very apprehensive and lachrymose, as if some evil were impending, in the evening, lasting two hours, 1.
He dreads the return of dawn, and the most trivial details of daily life seem insupportable to him, 55.
Very great irritability, and unwonted harshness of demeanor, 54.
Previously an affectionate father, his children instead of diverting his mind from care, now became simply burdensome to him; he had to force himself by a strong effort to attend to them, and his irritable temper was shown towards them especially; this was the more remarkable, as being quite opposed to his ordinary disposition, for he had always been a fine example of the "mens sana in corpore sano," 55.
Very passionate and spiteful temper, 2.
Very peevish and excited; everything goes wrong, and she is ready to quarrel with every one (after seventeen days), 1.
Feelings easily disturbed, as if something was always happening to trouble her, 54.
Morbid sensitiveness; easily and frequently moved to tears, 55.
Stubborn obstinacy, 2.
Intellectual. [20.]
Intellectual weakness, and paroxysms of dementia, accompanied by severe headache, 2.
Mind incoherent, 17a.
Inability to thin connectedly or to follow a train of reasoning, 2.
Loss of memory, .

HEAD

Vertigo.
Vertigo, 6.
Vertigo, especially mornings or evenings or after meals, 2.
Vertigo, with reeling, 2.
Vertigo, with confusion of the head, 2.
Vertigo and dulness, frequently with stomachache, and pains in the kidneys and bowels, 2.
Violent vertigo (after one hour), 4. [30.]
Sensation of intoxication; he cannot keep his head from falling on his breast, 2.
General Head.
Congestion of the head, 6.
Congestion to the head, with symptoms, threatening apoplexy, especially after meals, 2.
Cerebral excitement, evinced by mild intoxication, and sometimes cerebral congestion, 16.
A degree of cerebral excitement has occasionally shown itself; symptoms of slight congestion, which have given rise to a condition analogous to that of the intoxication produced by alcoholic drinks, 10.
Sense of weakness in the head, with drowsiness and inability to collect his thoughts, 2.
Dulness and heaviness of the head, 1.
Heaviness of the head (second day), 14.
Heaviness of the whole head after dinner, making her very fretful (after six days), 1.
The head is very heavy on stooping (after thirteen days), 1. [40.]
Head very uncomfortable (after a few doses), 39.
Sensation of fulness in the brain, as if it were full of fluids, with frequent and copious discharge of mucus from the nose, which seems to relieve the head, 2.
Sensation as if a great quantity of water was forced into the brain, with heaviness of the head, and drowsiness without being able to sleep, 2.
Headache, 12 ; (after one hour), 4.
Headache, with inclination to vomit, and sensation as if a nail had been driven into each temple, 2.
Headache, as if from metastasis, with delirium, weakness of mind, loss of memory, and paroxysms of fright and dementia, 2.
Constant headache, .

EYE

Objective.
Fixed look, 55.
Ferrety eyes (second morning), 37.
Dark rings around the eyes, 52. [90.]
Dark circles under the eyes, 54.
Eyes swollen, red, and painful, with great lachrymation and photophobia, 2.
Swelling of the cornea, as from an internal tumor, wich is pushing its way out, 2.
Sunken eyes, surrounded by blue rings, 56.*
A condition of the eyes resembling catarrhal ophthalmia, 16 . Obscuration of the cornea, as if it was entirely covered by a cataract, 2.
Peculiar state of the eyes; pupils dilated, and both eyes were in a state of incessant motion; these motions strongly resembled those of a child who has congenital cataract, that is, constant oscillation; he found himself quite unable to fix them on any object, 5.
Purulent mucus in the canthi, 1.
Discharge of purulent mucus from the eyes in the evening, 1.
Subjective.
Woke in the morning with an uneasy feeling of the left eye; the edge of the orbit at the external part tender on pressure; eyelids swollen and infiltrated on that side. The following morning, right side similarly affected; the tenderness was evidently seated in the periosteum of the orbit, and exclusively at the outer side. On the following day, a strange sensation was felt; it appeared like a pain extending in a direct line from the external border of one orbit to that of the other at the same spot; the sensation was very peculiar and difficult to describe; it was pain and something more, 42. [100.]
After an hour he awoke with violently increased pains in the eye, with profuse lachrymation and burning in the nose and throat, 25.
Burning of the eyes and redness of the lids, with lachrymation of the right eye, 1.
Burning in the eyes, in which purulent mucus is secreted, in the evening (fourth day), 1.
Violent burning in both eyes in the afternoon (fourth day), 1.
Pressure and burning in the eyes as if proceeding from the forehead, 2.
Cutting pain in the right external canthus in the evening (second day), .

EAR

Otorrhœa of yellow matter often mixed with blood, 2.
A feeling as though something had fallen in front of the ears, or as if a leaf were lying in front of them; still she heard well, 1.
It seems as though something had fallen in front of the ear, with tearing in the ears, 1. [140.]
Distensive pain and digging in the ears, as if an insect had got into them, 2.
Painful boring in the right ear, 1.
A violent pain in the left ear, as if one were boring about in it (after sixteen days), 1.
Cutting pains in the internal ear, 2.
Lancinating and tickling pains in the ears, with desire to cough, 2.
Transient sticking extending into the left ear, making her start (second day), 1.
Violent sticking in the right ear, frequently during the day (after five days), 1.
An extremely violent stitch in the left ear extending into the head, in the evening in bed (third day), 1.
Tearing, now in the right, now in the left ear, for a long time, 1.
Frequently repeated tearings in the right ear, which becomes very sensitive on account of them, in the evening (after four days), 1. [150.]
Painful tearing deep in the right ear, in the forenoon (second day), 1.
Violent tearing in front of the right ear, extending into the temple, so that the whole side becomes painful on account of it (second day), 1.
Some violent tearings in front of the left ear, extending into the temple, in the bones (second day), 1.
A painful gnawing within and behind the left ear, 1.
Itching in the left ear, 1.
Hearing.
Hardness of hearing, 2.
Hearing almost gone (fourth day), 15.
Ringing in the ears, 24.
Buzzing and ringing in head, 49 ; (three hours after third dose), 26.
Vibration and roaring in the ears, 2.

NOSE

Objective. [160.]
Ineffectual efforts to sneeze, 1.
Sneezing (first day), 35.
Frequent sneezing with running of clear water from the nose (third day), 1.
Frequent sneezing with lachrymation, 2.
Running from the nose, 24.
Coryza (fourth day), 34.
Symptoms of severe coryza, and of bronchitis, with the exception of fever and muco-purulent expectoration, 16.
Acute coryza; great redness of the mucous membrane of the eyes, nose, throat and palate, with profuse lachrymation, violent sneezing, and running of water from the nose , frequent irritation to cough and swelling of the upper lids; this coryza lasted for a long time, 25.*
Fluent coryza, the head being badly stuffed up, 2.
He can get scarcely any air through the nose on account of catarrh, in the morning after waking (after twenty-three days), 1. [170.]
(The catarrh previously existing disappeared), (after eight days), 1.
Found him in bed with his head wrapped up in a flannel nightcap; he had got a desperate cold, somehow, the day before, with which he woke up, but was getting better (second morning); he took no more Iodide, and was free from his desperate cold the next day, 38.
*Accumulation of very tenacious mucus in the nostrils, 2.
Profuse discharge of thick yellow mucus from the nose, 1.
*Discharge from the nose of greenish-black or yellow matter, of a foul and sickening smell, 2.
Burning water runs profusely from the nose and makes the skin sore, 1.
Nosebleed, whereby she lost more than half a pound of blood in two hours (second day), 1.
Violent nosebleed, which could not be stopped by anything (after eleven days), 1.
*Discharge from the nose of decomposed greenish-red blood, 2.
Subjective.
Feeling in the upper part of the nose as though a leaf were lying in front of it, with burning (sixteenth day), . [180.]

FACE

Objective.
Look characteristically quick and anxious, 52.
Remarkably earnest, wild, uncertain look, 51. [190.]
Remarkably sad and dejected expression of countenance, 51.
Looks sometimes excited, sometimes depressed, 54.
Paleness of face (after one hour), 4.*
(Great paleness of the face, with the spasmodic attacks), 1.
Face colorless and transparent-looking, like a porcelain mask, 2.*
Discolored complexion, 51.
Earthy-looking complexion, 52.
Bistre-colored complexion, 56.
Complexion rather yellow, 55.
Yellow, bilious complexion, with black circles around the eyes, 2. [200.]
Complexion more yellowish-green than dead white, 54.
Face yellow, greenish, dark, and much emaciated, 2.
Red, puffy, inflamed face; with a phlyctenoid eruption, 2.
Face very red (after three hours), 25.
Swelling of face, 49.
Swelling of the face, particularly of the eyelids, and of the submaxillary region (three hours after third dose), 26.
Inflammation and swelling of the facial bones, 2.
Emaciation of face and neck, 52.
Lengthened visage, 54.
Subjective.
Face very sensitive to air, which also aggravates all the symptoms of that part, 2. [210.]
An indescribable pain extending out from the left ear, and if she only moves the hand towards the ear without even touching it, it creeps over the whole side of the face, as though it were mesmerized; in the evening, 1.
Cheeks.
Wrinkled, flabby cheeks, 51.
Swelling of the left cheek for three days (after fourteen days), .

MOUTH

Teeth.
A feeling as if the teeth were too long, with painfulness of them, in the evening, 1.
Grumbling in a left lower hollow back tooth (after thirteen days), 1.
Grumbling in a hollow tooth, when walking in the open air (sixth day), 1.
Toothache, with swelling of the cheek, 2.
Painful griping in a left lower hollow back tooth, in the evening (first day), 1. [230.]
Painful drawing in a left lower back tooth, 1.
Tearing in the left upper row of teeth (fourth day), 1.
Painful tearing in the right upper back teeth and in the margin of the right orbit (twelfth day), 1.
Feeling of tearing in both lower rows of teeth, and a feeling as if a weight hung from the lower jaw, in the evening (first day), 1.
Violent ulcerative pain in the teeth, beginning in the evening and continuing the whole night, and even the next morning (after five days), 1.
Gnawing in the right upper teeth, afterwards in the left ear, and at last in the tendons of the hollow of the left knee, in the forenoon (second day), 1.
Violent jerking or shooting in the right eyetooth, scarcely to be endured, frequently lasting for an hour but worse in the evening after lying down till midnight, and from 4 to 5 A.M.; aggravated by cold, relieved by warmth; at times the pain is so great that it seems as though the tooth would break off, or as if a worm were digging in it (after twenty-five days), 1.
Gums.
Tumefaction of the gums, 16.
The gums is swollen and painful (after twenty-five days), 1.
Swelling of the gum about a hollow tooth (after fifteen days), 1. [240.]
Painful stitches in the gum, frequently during the day (after eighteen days), 1.
Slight though strongly marked, soreness of the gums , with headache and nausea, 12.
Ulcerative pain in the gum of the right lower row of teeth (after eighteen days), 1.
The gum of the right side is painful as if ulcerated and swollen, for several days (after eight days), 1.

THROAT

Objective.
Inflammation and swelling of the whole throat and even of the neck, 2.
Yellowish-gray spots and ulcers in the throat, 2.
Subjective.
Dryness and frequent cramp in the throat, with apprehensiveness, 3.
A feeling of dryness and itching was experienced in the throat, with burning at the epigastrium, copious salivation, running from the nose, intense injection of the conjunctivæ, and lachrymation, 24.*
Disagreeable dryness and irritation in his throat (third day), 7.
Burning and rawness in the throat, as from heartburn (thirteenth day), 1. [290.]
Feeling of constriction in the throat, 6.
Choking in the throat, as if something were sticking in it; on hawking, a piece of thick mucus was raised, and the choking ceased (after six days), 1.
Dull stitches and ulcerative pain in the left side of the throat, only when swallowing, worse in the evening, 1.
Sore throat; sticking and a feeling of pressure in it on swallowing; even on reading she experiences pain (twenty-first and twenty-second days), 1.
Scraping sensation in the throat, with sanguineous congestion, 2.
Rawness and scraping in the throat, 1.
Rawness and dryness in the throat, with frequent hacking cough, in the morning in bed (third day), 1.
Sense of occlusion of the posterior nares (fourth day), 34.
Burning and uneasy sensation in the œsophagus and stomach, 18.
The act of swallowing was painful and difficult, and there were redness and swelling of the soft palate and tonsils (particularly the right), 24.
External Throat. [300.]
The glands in the neck enlarged, 31.*
The glands in the neck suddenly enlarged, and to a degree highly disfiguring; at least two months elapsed before the swellings showed the slightest symptom of subsidence (after three weeks), 32.
Swelling of the whole thyroid gland, increasing very rapidly, with some sensitiveness to touch, and pressure (after eight days), .*

STOMACH

Appetite.
Improvement of the appetite, 24.
Appetite usually increased; it is remarkable how soon after taking Iodine the desire for food arises (first day); diminishing or disappearing (second day), 14.
Great hunger, but he can scarcely eat on account of bad digestion, nausea, and vomiting, 2.
Bulimy, 52.
Desire for milk, wine, and spirits, 2.
Loss of appetite, 27.
Total want of appetite; or rather she was convinced she could not eat, 56.
Anorexia, 24, 53. [320.]
Aversion to all food, 2 ; (after seventeen days), 1.
Aversion to broth, 1.
Thirst.
Thirst, 24 ; several evenings in succession (after five days), 1.*
Constant thirst (after fourth dose), 9.
Great thirst; the whole day and even at night (after three and fifteen days), 1.
Eructation and Hiccough.
Eructations with taste of food long after eating, 2.
Frequent gulping eructations of a large quantity of air, 1.
Frequent regurgitations of bitter matter, with desire to vomit, 2.
Raising of phlegm morning and evening, and often after meals, 2.
Hiccough, in the evening (after four days), 1. [330.]
Very frequent, empty, hiccough-like eructations, 1.
Constant inclination to waterbrash, without its really occurring, 1.
Nausea and Vomiting.
Nausea (immediately), 4.*
Nausea in the stomach, even vomiting, 1.
Nausea, with pressure in the stomach, 1.
Nausea, with great straining, and tearing sensation in the chest, .

ABDOMEN

Hypochondria.
Pains extending from the liver into the stomach and chest, and giving rise to frequent suffocative paroxysms, 2.
Violent burning externally in the left hypochondrium and afterwards in both groins (after six days), 1.
Sensation of swelling and distension in the hepatic region, with throbbing and cramplike pains, 2.
Sensation of fulness and heaviness of the spleen, 2.
Painful constriction in left hypochondrium, on a line with the cardiac orifice of the stomach (soon after); this sensation was felt after each daily dose of a spoonful, for five days, 51.
Stitches in the left hypochondriac region, 1.
Sharp stitch in the right hypochondrium, and at the same time in the left side of the chest, on talking (twelfth day), 1.
Umbilical and Sides.
Distension about the umbilicus and movings in the abdomen, followed by two soft stools (sixteenth day), 1.
Great painful distension beneath the umbilicus, disappearing after a stool, 1. [380.]
Gripings and movings about the umbilicus, 1.
Griping and burning about the umbilicus (after eighteen days), 1.
Cutting and burning about the umbilicus, with qualmishness in the stomach and inclination to eructate, which afterwards even occurs; violent itching externally about the umbilicus, and inclination to emission of flatulence; in frequent attacks, lasting a quarter of an hour, in the afternoon (after seventeen days), 1.
Cutting pain in the left side near the umbilicus (second day), 1.
Stitches in the left side of the abdomen at the side of the umbilicus (fourteenth day), 1.
Violent tearing, extending from both sides of the abdomen towards the umbilicus, as if the flesh would be torn off, in the afternoon (fourth day), 1.
General Abdomen.
Swelling of the abdomen as in ascites, with emaciation, constipation, constant thirst, and scanty, turbid, red, and brown urine, 2.
Sudden distension of the abdomen as if it would burst, disappearing after emission of flatus , afterwards diarrhœa twice, in the morning after waking (seventh day), .*

RECTUM AND ANUS

Inflammation and swelling of the rectum and anus, 2.
Hæmorrhoids, with very painful pimples at the anus, 2. [420.]
Great itching at the anus, especially at night, 2.

STOOL

Diarrhœa.
Diarrhœa (second day), 14.
Serous diarrhœa, unattended by febrile action, 16.
Diarrhœic stools mixed with glairy matter, bile and blood, with anorexia, great weakness emaciation, and strong and painful beating of the heart, 2.
Purging and vomiting at the same time (after four doses); purging lasted several days, notwithstanding the exhibition of demulcents and opiates, 9.
Red, dark, semiliquid stools, as if caused by intestinal hæmorrhage, 2.
Light green and yellow watery stools, 2.*
Slimy and bloody stools, 2.
Stools with constant tenesmus, and spells of weakness, 2.
Stool hard (fifth day), 1.
First hard, then soft stool, preceded by some colic (third day), 1.
Constipation. [430.]
Constipation, 50, 54, 55.
Obstinate constipation followed by diarrhœic stools, 2.
Stool very hard; it is only with extreme exertion that she can pass a few small fæces (first day); after five days the stools became more natural and occurred more frequently, 1.
Stool omitted (second day), 1.

URINARY ORGANS

Bladder and Kidneys.
Burning and throbbing pains, as from an abscess, passing from the kidneys into the abdomen, 2.
Cramps in the kidneys, with yawning, nausea, vomiting, raising of phlegm, urging to urinate and desire to remain in bed, 2.
Digging in the kidneys, with heat and distensive pains, 2.
Lancinating and burning pains in the kidneys ineffectual urging to urinate, and tenesmus, 2.
Nephritic colic, with inclination to ease the pain by clenching and grinding the teeth, digging and weakness in the spine, and complete retention of urine, 2.
Sensation of congestion and heaviness in the neck of the bladder, with priapism, 2. [440.]
Contraction of the neck of the bladder just as urination begins, and during its continuance, 2.
Irritable bladder, 43.
Urethra.
Muco-purulent discharge from the urethra, of a gummy consistency, with inflammation of the penis, 2.
Discharge resembling blennorrhagia, with tearing and burning pains in the penis, constant priapism, colic, and feeling of exhaustion, 2.
Burning and tearing pains in the urethra, frequently with emission of blood, 2.
Micturition.
Frequent urging to urinate, 2.
Painful urging to urinate (fifth day), 1.
(The urging to urinate which usually accompanied menstruation was wanting), 1.
She is obliged to rise at night to urinate (after four days), 1.
Frequent and profuse discharge of urine as clear as water (after three days), 1. [450.]
Greatly increased discharge of urine (sixteenth day), 1.
The emission of urine was materially increased, the patient passing from forty to fifty quarts in the course of twenty-four hours, drinking in the same proportion; each time the Ioduret of Potas. was suspended this accidental supersecretion ceased, but it was reproduced as soon as its use was resumed, 10.
The absolute quantity of urine discharged was not increased unless, owing to the dryness of the throat, more water was ingested, .

SEXUAL ORGANS

Male.
Penis swollen, inflamed , with constant semi-erections and sexual desire, 2.* [470.]
Extensive swelling of the glans penis , with paraphimosis, 2.*
Erection even after an ejaculation, 2.
Chancre-like ulcers, with raised edges on the penis, with burning in the urethra, 2.
Raised, suppurating, syphilitic-looking condylomata on the penis, 2.
The penis is excoriated by the least friction, 2.
The left testis had almost entirely disappeared; it was reduced to the size of a pea, 21.
The right testicle was found to have disappeared; the left was about the size of an almond; coition was accompanied by pain, erection taking place slowly and lasting a long time; the duration of the venereal act was much prolonged, and no emission of semen took place (after twelve months), 57.
Descent of the testicles, with serous effusion into the scrotum, 2.
Compressive pains in the testicles, with sensation as if they were returning into the pelvis, 2.
Lancinating and throbbing pains in the scrotum, frequently after coition, 2. [480.]
Greatly increased sexual desire, 2.
Seminal losses, and frequent profuse nocturnal emissions, 2.
Tardy or premature ejaculation of semen, 2.
Female.
Inflammation and swelling of the uterus, with sensation as if its walls were being scraped, 2.
The cervix uteri is swollen and contracted, 2.
Chancre-like tumors on the cervix uteri, 2.
Cramps, burning, and contractions of the cervix uteri, 2.
Constrictive pains in the uterus, impeding parturition, 2.
Severe burning, tearing, and twisting pains in the ovarian region, especially on the right side, 2.
Sensation of congestion and swelling in the ovaries, with pain as from a corrosive tumor there, 2. [490.]
Biting in the pudenda with leucorrhœa, .

RESPIRATORY ORGANS

Larynx, Trachea, and Bronchi.
Accumulation of mucus in the larynx and bronchi, 2.
Considerable accumulation of mucus, and of what seems like false membranes, in the throat and larynx, with difficult respiration and rattling, 2.
Affection of the mucous membrane of the air-passages, 12.
All the symptoms of severe spasmodic croup (fourth morning), 7.
Sticking in the air-passages and a feeling of rawness in them, which obliges hawking, whereby she expectorates mucus, 1.
*Raw pain in the larynx, as if from granulations, 3.
Voice. [510.]
Occasional and trifling alteration in the sound of the voice, 2.
Voice as in catarrh, 1.
Hoarseness and frequent aphonia, with much obstruction in the throat and larynx, and weakness of the chest, 7.
Her voice is short, like her answers, 54.
Voice feeble, at times rather tremulous, 51.
Loss of voice (third day), 7 ; for a long time, 41.
Cough and Expectoration.
Inclination to cough, 6.
Constant provocation in the larynx to a dry cough (after six days), 1.
Cough worse in the evening or at night and preventing sleep, 2.
Severe cough, especially towards evening, 2. [520.]
Short hacking cough caused by rawness in the throat (soon), 1.
Whistling cough, as in croup, or spasmodic, as in hooping-cough, 2.
Dry cough, several mornings in succession (after six days), 1.
Dry cough, with a feeling of soreness in the larynx, in the evening (after fourteen days), 1.
Dry cough, morning and evening (after sixteen days), 1.
Deep, hollow cough, with whitish and greenish expectoration, , .*

CHEST

Objective.
Emaciation and debility of the right side of the chest, as from pulmonary disorganization, with very copious purulent expectoration, 2.
Inflammation of the chest, with sensation as if the lungs were swollen and obstructed, fever and great dyspnœa, 2.
Subjective.
Pains in the chest, as if the lungs contained large tubercles or cavities, 2.
Oppression, with cramplike pains in the chest, and suffocative paroxysms; inability to remain lying, especially at night, 2.
Constant oppression of the chest, 6.
Pains in the chest as if cut to pieces, in the evening (third day), 1.
Dull sticking in the middle of the chest, disappearing on moving about (after five days), 1.
Sharp sticking in the left side of the chest, in the evening (fifteenth day), 1.
Fine transient stitches deep in the middle of the chest, 1.* [540.]
Sharp stitches in the upper part of the left chest, while sitting bent over, disappearing after becoming erect, 1.
Sharp stitches in the right costal region, behind the breast, 1.
An extremely violent stitch in the middle of the chest, while walking, 1.
Sore pain with sticking low down in the chest, in the lowest right ribs, at 8 P.M., 1.
Front.
Sharp sticking and pressure in the middle of the sternum, in the afternoon (sixth day), 1.
Violent stitches in the middle of the sternum, extending to the shoulders, 1.*
Sides.
Several sharp stitches in the right side of the chest, 1.
Pain in the left side of the chest, as if sore externally, worse when touched (after twelve days), 1.
Mammæ.
The breasts began to diminish in size, but the supply of milk was especially diminished (soon), 13.

HEART AND PULSE

Præcordium.
Heart feels as if enlarged and heavy, and beats very slowly, 2. [550.]
Sensation as if all the vessels of the heart were dilated, with inclination to take deep inspirations, and to sigh as if fetching breath, 2.
All the symptoms of endocarditis; oppression, faintlike exhaustion, tumultuous, violent intermitting, and irregular action of the heart and pulse, with tensive pain across the chest, especially affecting the right ventricle, which gradually became dilated (after two weeks), 27.
Lancinating, cutting, and burning pains in the heart, 2.
Lancinating, burning, and rheumatic pains in the heart, with sensation as if it were surrounded by water, 2.
A few sharp stitches in the region of the heart, frequently while walking (fifth day), 1.
He is afraid to stir; the least movement aggravates the pains in the heart, 2.
Heart's Action.
Palpitation, 29, 50, 54, 55.
Strong palpitation of the heart, 2.
Very annoying palpitation, 52.
(Cure of palpitation of the heart, which she had previously been subject to), 53. [560.]
Intermitting beats of the heart, with lancinations, cramps in the chest, stupor, and loss of breath, 2.
Pulse.
Accelerated pulse, 29 ; (tenth day), 24.
Pulse rapid and small, 52.
Pulse very rapid and irregular, 56.
Quick and very full pulse (after four doses), 9.
Pulse almost always strong and quick, 2.
Pulse quick and small, 17a.
Pulse very quick, at least 120, but varying every moment, 54.
Pulse 130, 30.
Pulse hard, tense, not frequent, 6. [570.]
Pulse small, soft (after three hours), .

NECK AND BACK

Neck.
Hard, painless tumor, like a wen, on the nape of the neck, 2.
Stiffness and swelling of the neck, with cramplike pains and great difficulty in moving the head, 2.
Sticking in the right side of the nape of the neck, while lying down, 1.
Back.
Curvature of the back, with weakness of the chest, 2.
Lancinating and burning pains in the back, with inability to remain lying, 2.
Dorsal.
Throbbing several times between the shoulders (after seventeen days), 1.
Lumbar.
Pain in the small of the back like that before menstruation, with two diarrhœa-like stools (after fourteen days), 1.
Violent pain in the small of the back, so that she could not lie quietly anywhere (after sixteen days), 1.
Feeling as if screwed in in the small of the back, very painful (after three days), 1.* [580.]
Frequent sharp stitches in the small of the back, while sitting (third day), 1.
Constant pain in the small of the back, almost as if beaten, especially when sitting bent, 1.
Violent pain in the small of the back the whole night as if beaten, so that she does not know how she shall lie (after five days), 1.
Digging in the kidneys and loins as if they were stroked with hot iron rods, 2.
Sacral.
Pain in the coccyx as if she had fallen upon it (after six days), 1.

EXTREMITIES IN GENERAL

Objective.
Burning, red swelling of the arms and legs, with great tendency to suppuration, 2.
Gouty swelling of the joints, with inability to move them, 2.
Rapid growth of the nails, 2.
Tremor of the limbs, 5.
Trembling of the limbs and unsteadiness of the extremities, as in an intoxicated person, so that the patient was obliged to lie down, 6. [590.]
Spasms and convulsive movements of the arms, hands and legs, 2.
Jerkings of the limbs, especially violent in the left arm, also in the whole of the face, especially on the left side, with great anxiety, apprehensiveness, and palpitation; this attack was repeated six times on the first day and twice on the second day, but was more violent and lasted an eighth of an hour and ended with vomiting and violent headache; on the second day violent rolling of the eyeball, both pupils contracted, the facial muscles contracted, the left corner of the mouth drawn downward, the mouth opened and closed numberless times while uttering unintelligible words; violent palpitation, short rapid respiration, pulse hard and full, forehead, neck, and chest covered with perspiration, face fiery red, with loss of consciousness; after the paroxysm, trembling, weeping, complaints of heaviness of the left arm, abdomen small, soft, tongue white rather than yellow; efforts to vomit relieved by vomiting; these attacks were repeated on the two following days, after which there were no spasms, only cramp in the throat with a sensation of dryness, 3.
Subjective.
Pains in the joints as if dislocated and bruised, 2.
Sprained pains in the joints of the arms and legs, 2.
Tearing just above the right malleolus, in the left index finger and right arm, though not in the joints (tenth day), 1.

SUPERIOR EXTREMITIES

Paralytic rigidity of the arms, 2.
Arms lost all power (fourth day), 15.
Lancinating and cramplike pains in the arms, with œdematous swelling, 1.
Shoulder.
Pain in the tendons of the right shoulder, on motion and touch, like a tension and as if swollen, 1.
Paralytic pain in the shoulders, only on moving them (after four days), 1. [600.]
Transient tearing in the right shoulder and afterwards extremely violent tearing in the right ear, 1.
Violent tearing in the left shoulder, 1.
Transient bruised pain in the left shoulder, 1.
Elbow.
Tearing in the left elbow, now in the shoulders, now in the right elbow (after seventeen days), 1.
Forearm.
Pain like a tension and sticking in the articular extremity of the radius, on moving the right index finger, 1.
Feeling of cramp in the right forearm above the wrist, on moving it (second day), 1.
Wrist.
Tearing in the right wrist, afterwards itching on it, not relieved by scratching, followed by the appearance of an itching vesicle (after twelve days), 1.
Hand.
Swelling of the hands as if from chilblains, 3.
Very characteristic trembling of the hands, 54.
Tearing in the metacarpal joints of the fingers of the left hand, in the evening (third day), 1. [610.]
Bruised pain in the margin of the right hand above the little finger, 1.
Fingers.
Very painful swellings on the fingers, like paronychia, 2.
Pinching on the first (metacarpal) joint of the left thumb, 1.
Tearing in the index finger, from the base to the tip, 1.
Tearing in the inner surface of the right ring finger, which is thereby involuntarily flexed and for a long time cannot be extended, .

INFERIOR EXTREMITIES

The gait is disturbed, 54. [620.]
Affected in his lower limbs; his legs gave way under him (fourth day), 15.
Legs stiff, or very weak and unable to support the body, 2.
Painful weakness of the legs, 53.
Hip.
A sharp stitch in the left hip on every step, so that she was obliged to limp, 1.
Gnawing in both hip-bones, 1.
Thigh.
The upper part of the thighs seem to be compressed during menstruation (after fourteen days), 1.
Some sharp stitches in the upper part of the left thigh (after sixteen days), 1.
A stitch frequently, now in the thigh, now in the tibia (eleventh day), 1.
Tearing in a small spot in the middle of the left thigh, whereupon the thigh as far as the knee was painful, as if paralyzed (third day), 1.
Tearing and sticking in the posterior portion of the right thigh (third day), 1. [630.]
Tearing pain in the left thigh-bone (second day), 1.
Extremely painful tearing in the thigh, extending to the knee, disappearing when lying upon the sound side; lying upon the painful side or the back, was intolerable, on and after waking at 11 P.M. (after thirteen days), 1.
A gnawing pain in the middle of the right thigh, while sitting in the evening with the right thigh over the left (first day), 1.
Knee.
Tearing twitching in the right knee, 1.
Tearing above the hollow of the knee, immediately afterwards also below it (second day), 1.
Tearing in both knees, at night (after six days), 1.
Several transient tearings in the outside of the left knee, while sitting, 1.
Violent tearing in the left knee, as if in the periosteum, with a feeling as though it were swollen, at night, lasting two hours (after six days), 1.
Leg.
Swelling of the legs in the evening, 2.
Violent pain in (after several days), . [640.]

GENERAL SYMPTOMS

Objective.
Nervo-sanguine temperament, 2.
Augmentation of the secretive action of the mucous membranes, especially of those lining the genital organs, 16.
Excessively thin, 30.
Emaciation, 29, 55.
Considerable emaciation, 53. [660.]
Considerable general emaciation, 51, 54.
Great emaciation, with accumulation of water in different internal organs, 2.
Remarkable emaciation, 28.
Marasmus resembling the third stage of phthisis, 29.
Extreme marasmus, 56.
It affects the fibrous structures, as the periosteum, and capsular ligaments of joints, 43.
Ostitis with suppuration, 2.
Trembling, 55.
General trembling, 29.
Some have been affected with spasms, and even a degree of subsultus tendinum, 10. [670.]
Nervous twitchings and facial contortions, 2.
General depression, 24.
General depression, 56.
Languor and weakness, which did not disappear for several days after suspension of the medicine (after four days), 15.
General debility, 53.
Great general debility, 2.*
Marked debility, 54.
His frame greatly debilitated, 17.
Notable diminution of strength, 29.
Extreme weakness, 29. [680.]
Great prostration of strength (after four doses), 9.
The vital powers were prostrated to the lowest degree, every moment seemed about to snap the thread of his earthly career, 17a.
Fell unconscious (fourth day), 15.
He emitted a most abominable smell from his whole person, .

SKIN

Objective.
Redness of skin, as after strong friction, 2.
Skin dried up, and as if glued to the bones, 2.
Skin in general rough, like hog skin, 3.
Skin easily injured, the slightest wound tends to become a bad sore, 2.
Swellings resembling condylomata or wens, 2.
Eruptions, Dry. [710.]
Different forms of cutaneous disease, as acne, eczema, and purpura, 16.
Cutaneous eruption, sometimes; when these eruptions make their appearance the patient is disquieted; they are generally of the character of urticaria; if the medicine be continued they assume the character of eczema and prurigo; in some cases, especially when the eruption appears on the face, a congestion of the cellular tissue, beneath the skin, is added to the other symptoms, giving rise to slight excrescences, having the appearance of tubercles; the eruption will disappear in a few days, after discontinuance of the medicine, 11.
Different eruptions, and more especially eruptions of a psydracious form, somewhat resembling the pustules of acne, with this difference, that they are not confined to the parts habitually affected with acne; thus they are found not only on the face and shoulders, but on every part of the body without exception; in one case we may have eczema, in the other herpes, while in others it may cause simple erythema; in two patients, at two different periods, there appeared an eruption of papulous erythema on some parts, of erythema nodosum on others, and in a patient affected with cancer of the face, to whom it was given in rather large doses, it on several occasions caused an eruption of impetigo on the hairy scalp, and of a rupia, offering the characters of a cachectic rupia, on the legs and forearms, symptoms which disappeared as soon as the remedy was omitted, and showed themselves again when its use was renewed, 10.
Miliary and urticarious or vesicular eruptions, with itching and burning, which allow no rest, 2.
Purpura, in a predisposed subject, and of course erythema and other symptoms of iodism, 44.
Many small yellow spots appear, now in one place, now in another, which exfoliate, like herpes, 2.
Blotches on the face and other parts of the body (after a few doses), 39.
Red blotches on different parts of the face, 2.
I have seen it produce on three several occasions, after a fortnight's use, a genuine spotted disease on the legs of a gentleman; in the case of a lady I ordered it for removal of very serious tertiary symptoms of syphilis; it caused towards the termination of the cure a petechial eruption on the lower limbs, .

SLEEP AND DREAMS

Sleepiness.
Frequent yawning, as though she had not slept enough, without sleepiness, 1.
Excessive, frequent yawning (fifteenth and sixteenth days), 1.
Invincible drowsiness, after 2 P.M., 2.
Heavy and painful sleep in the morning, and after meals, 2.
Deep sleep during the first half of the night; wakefulness in the morning, 2.
Sleeplessness.
Sleeplessness, 53, 54.*
Night almost sleepless; she was quite wide awake most of the time, and only became sleepy towards morning (after thirteen days), 1.
Nightly restlessness, 50.
Restless sleep (after fourteen days), 1.
Restless sleep, from which he awakes with a start and a feeling of distress, as if caused by some strong emotion, or the sense of a great calamity, 55.
Sleep restless, especially in the morning, with dreams, which are not remembered on waking, 2.
Sleeps much less soundly than usual, but has no nightmare, 51.
She started up during the first sleep, but soon fell asleep again (fifth day), 1. [770.]
She wakes every hour, at night (after fourteen days), 1.
Sleep was disturbed and unrefreshing, 24.
She cried aloud in sleep, towards morning, but after waking remembered nothing of it (after three days), 1.
Dreams.
Joyous dreams, 1.
Very anxious dreams (after thirteen days), 1.
Dream of falling and consequent violent starting up, in the evening, while napping (after eleven days), 1.
Dreams that she would be killed (after fourteen days), 1.
Nightmare, 54.

FEVER

Chilliness.
Chilliness from afternoon till the next morning (after forty-six days), 1.
Chilliness from 6 to 10 P.M., disappearing after lying down (after five days), 1. [780.]
Chilliness with sleepiness, from 6 to 8 P.M., beginning by creeping up the back, and extending over the whole body (after seventeen days), 1.
Chilliness, with shaking, at 10 P.M., lasting half an hour (third day), 1.
Chilliness from 4 to 7 P.M., with thirst; she was able to get warm in bed, but not by the stove (after fourteen days), 1.
Chilliness, which was difficult to relieve by the warmth of a stove, in the afternoon (tenth day), 1.
She was so chilly at night that she could not get warm (after three days), 1.
Shaking chill at night, on frequent waking (after eleven days), 1.
Shivering (first day), 35.
Shivering and coldness all over; he feels frozen, and cannot get warm with any amount of covering, 2.
Violent shivering fit (one hour after fourth dose), 9.
Constant shivering-creeping, with icy coldness over the hands, with pressure and griping in the lower abdomen, during the menses, 1. [790.]
Creeping in the back, followed by coldness of the whole body, in the evening (fourth day), 1.
Coldness of the feet, with swelling, 2.
Heat.
Heat of the skin (after fourth dose), 9.
Heat, followed by perspiration, in the afternoon, from 1 to 3 (third day), 1.
Heat, with copious sweat, malaise, itching, and bruised sensation in the skin, 2.
Great heat, as after overexertion, followed by excessive coldness with trembling, 2.
Flushes of heat, with dulness in the head and discomfort of the body (fourth day), 1.
Symptoms of fever (after some days), 17.
Fever, especially in the morning on waking, in the evening when going to bed, and during the night, 2.
Fever, with languor, coldness of the back and legs, urgent thirst, longing for sugared water, and loss of appetite, . [800.]

CONDITIONS

Aggravation.
( Morning ), Vertigo at 5 o'clock, disappearing after rising; headache; after rising, heaviness in side of forehead; heaviness in sides of head, disappearing in open air; screwing together in head; in bed, stitches from jaw to parietal bone; in bed, when lying on it, tearing, etc., in zygoma; after waking, lips full of mucus; from 4 to 5 o'clock, jerking in eyetooth; after rising, odor from mouth; after waking, numbness of mouth; in bed, rawness, etc., in throat; after waking, distension of abdomen, etc.; after waking, pains in abdomen, etc.; dry cough; restless sleep; on waking, fever; head hot, etc.; in bed, sweat.
( Forenoon ), Sticking in lower jaw, etc.
( Afternoon ), Heaviness in forehead; towards evening, heaviness in occiput; burning in eyes; tearing in abdomen; towards evening, severe cough; sticking, etc., in middle of sternum; from 4 to 7 o'clock, chilliness, etc., chilliness; from 1 to 3 o'clock, heat, etc.
( Evening ), Vertigo; headache; tearing, etc., in forehead; throbbing in temple; stitches in top of head; discharge of mucus from eyes; burning in eyes; burning in lids; in bed, stitch in ear; tearings in ear; pain over side of face; stitches, etc., in side of throat; thirst; hiccough; pain in stomach; beating in epigastric region; cough; dry cough, etc.; pains in chest; sticking in side of chest; tearing in metacarpal joints; tearing in fingers; swelling of legs; tearing in tibiæ; pain in instep; pinching in whole body; itching on instep; from 6 to 10 o'clock, disappearing after lying down, chilliness; from 6 to 8 o'clock, chilliness, etc.; at 10 o'clock, chilliness; creeping in back; when going to bed, fever.
( Night ), The symptoms; heaviness in forehead, etc., after lying down, till midnight, jerking in eyetooth; uneasiness in bowels; itching at anus; emission of urine; cough; oppression, etc., of chest; pain in small of back; tearing in knees; tearing in left knee, etc.; from afternoon till morning, chilliness; chilly; fever.
( Walking in open air ), Grumbling in hollow tooth.
( Sitting bent over ), Stitches in upper left chest; pain in small of back.
( Cold air ), The symptoms; headache.
( After dinner ), Heaviness of head.
( Heat ), Headache.
( After meals ), Vertigo; congestion of head.

SUPPLEMENT: KALI IODATUM. Authorities.

59 , Belgian Journal (Lancet, 1848 (2), p. 213), a man, æt. thirty-five years, took it for five months for acne indurata on the forehead, which it cured; 60 , Prof. A. Fournier, Med. Times and Gaz., Oct., 1877 (Amer. Journ. Med. Sci., Jan., 1878, p. 263), general effects; 61 , Dr. Colby, Pub. Mass. Hom. Med. Soc., vol. iv, 31, took one dose of 15 grains of Hydriodicum.

He suffered from a painful sensation of heat in his feet; in a few days this increased, and was accompanied by a trembling of the limbs and feeling of intoxication; his movements were uncertain from a tottering of his lower extremities; there were vertigo, dulness of the eyes, feeble, and often double vision, with a sensation of turning round. All these phenomena persisted for several weeks. Shortly after, the power of moving his lips and cheeks was lost, and he was unable to masticate. He had also vague feelings in the head, back, and limbs, which he could not describe. A day or two afterwards his gait was still faltering, with vertigo and feeble vision; the countenance was that of a drunkard; speech thick and indistinct; eyes apparently protruded, and a loss of appetite, 59.
In a paper contributed to the Revue Mensuelle de Méd. et de Chir ., September, 1877, Prof. A. Fournier, of the St. Louis Hospital, observes that while among the numerous and various phenomena which may follow the ingestion of Iodide of potassium, there are some which are of common occurrence and well known; there are others which have either escaped attention, or have only been imperfectly described. Among these may be ranged, he believes, a cutaneous affection, consisting in the production of small miliary, non-pruriginous, sanguinous spots, proceeding after the manner of purpura, and to which he proposes to give the name of iodic purpura, or petechial iodism. That the appearance of the exanthem, and the taking of the Iodide are not a mere coincidence, he concludes from the following observations: 1.

In all cases the purpura has appeared a very short time (from one to six days) after commencing the Iodile.

In some of the patients the same purpuric eruption has been produced several times after each new administration of the Iodile, and in three of these it occurred every time the medicine was used. Two cases are detailed in which this was the case three or four times.

In another case in which te purpura was produced on three successive occasions, it was found in all these that whenever the dose was notably increased, a marked aggravation or additional production of the eruption ensued.

As to the characteristics of this eruption, in all the patients the well-known appearances of purpura, and the impossibility of effacing them by pressure with the finger, were distinctly present, the petechial color due to extravasation being very obvious. The seat of the eruption, with one exception (when it was on the thorax, and that only), was in all the cases on the legs only, being always more confluent on their anterior than on their posterior part. It never descended to the foot, or extended beyond the knee. This purpura seems to assume an eminently discrete form, few spots being usually observed, about a hundred of these on each limb constituting the maximum of confluence, fifty or sixty, or even less, being the number usually observed. On the successive appearances the purpuric spots are even yet fewer in number. This rarity of confluence, and the especial localization of the exanthem about the anterior tibial region, impart to this variety of purpuric affection a somewhat peculiar physiognomy of its own. It is always a miliary purpura, that is, a petechial eruption of the smallest extent, resembling in size a millet-seed, the head of a pin, or at most, and that rarely, a grain of corn, or a small lentil. The spots are usually of a regular rounded form, and less often oval or irregular in form, and notched. The eruption never advances beyond this petechial and miliary condition. The spots are quite level with the skin, seemingly incorporated with the integument, the appearance of which they only modify by their bright color. Like as in purpura vulgaris, these spots give rise to neither local nor constitutional disturbance, inducing neither heat, pain, nor pruritus. Thus there is a great chance of this eruption passing unperceived, and it is always by accident that the patients have observed its existence, while undressing at the bath, etc., so that many cases have no doubt escaped the notice of patients and their attendants. The eruption comes on at an early period of the iodic treatment, and has completed its course in two or three days, at the end of which period it ceases to increase in confluence, even when the use of the medicine is continued. It remains for a certain time in the condition of purpurine petechiæ, after which the spots undergo the ordinary changes of color observed in cutaneous hæmorrhages, finally disappearing at the end of two or three weeks. When under the influence of a large dose of the Iodide, a new purpuric outbreak is produced: the intruding eruption is easily distinguished from that which has preceded it by the bright purpurine color of its spots, contrasting with the faded condition of the prior spots. It has a curious appearance, this intermixture in the same locality of petechiæ of different ages, with difference of color corresponding to the periods of their appearance.

This purpura is certainly a rare accident, or rather phenomenon, for there are few remedies which are more employed than the Iodide of potassium; and if iodic purpura were not almost an exceptional occurrence, it must have attracted the attention of observers. Professor Fournier, who, during the few years since he first became aware of its existence, has carefully sought for it, has not met with more than some fifteen cases.

All the subjects of the affection hitherto met with enjoyed either a flourishing or a medium condition of health; and although some of them seemed affected with a certain degree of "lymphatism," none could be said to suffer from anæmia or scrofula, and none had presented anterior hæmorrhagic proclivities. Any of these who were the subjects of syphilis exhibited only benign or medium forms of this, two-thirds of the cases being exempt from any specific manifestation of this disease at the time when the Iodide, which, in fact, was administered only as a preventive , produced the purpuric eruption. Further, in a negative point of view, neither sex, age, occupation, nor external temperature seemed to have exerted any influence. Nor can the eruption be attributed to excess of dose, since most of these patients had not taken more than 15 grains of the Iodide when the eruption had manifested itself. Still, quantity is not a matter of indifference, for when a given dose has been followed by purpura, a kind of tolerance of the remedy seems to be established, and no further manifestation ensues. But let the dose be much increased, doubled, for example, and a new outbreak of purpura may be immediately produced, although this is less confluent and less important than that which preceded it. But it is probably the individual predisposition which predominates over all the etiology, for however unknown and impenetrable in their nature, the existence of idiosyncrasies in regard to the action of certain remedies and articles of diet is beyond doubt. Iodic purpura in its nature takes its place in the group of affections termed by M. Bazin, provoquées indirectes or pathogénétiques . It is a medicinal eruption which ranges nosologically with the roseola from Copaiba, the erythema from Belladonna, the exanthems from Arsenic, the acne from Iodine, etc., 60.

At night, after retiring, had a terrible spasmodic pain at the root of the tongue, extending to both sides of the throat. For about fifteen or twenty minutes the pain was excruciating, causing a fear that death was impending. There was a sensation as if a spasm would close the pharynx, 61.

Kali Iodatum