Picric acid (Carbazotic acid), a trinitrophenol.

Formula, C6H3

(NO2 )3 .OH

Preparation , Solutions in alcohol (or triturations).

Authorities.

1 , Parisel, Thèse, Paris, 1868, took three pills, each containing 1/10 grm. of P. acid, and half an hour later took two more; 2 , same, proving on a man by a dose of 5 grms; 3 , same, proving on a woman with a dose of 4 grms; (Nos.

4 to 10 , L. B. Couch's provings, N. Y. Journ. of Hom., 2, 149, 1874.); 4 , Lance, took one dose of 30th cent. dil. on first, fourth, and seventh days; 4 a , same, another proving, one dose of 30th; 5 , L. B. C., took 30th dil. first day, two doses of 10th dil. third day, a dose of 30th fourth and sixth days; 6 , Sullivan, took a dose of 5th dil. first day, a dose of 30th dil. fourth day; 6 a , same, subsequent proving, a dose of 30th dil.; 6 b , same, subsequent took 30th dil. first, third, and fifth days; 7 , W. S. F., took 30th four days in succession, without result, then a dose of 1st cent. dil. in morning of first, third, and fifth days; 8 , J. E. T., having taken the 30th, 15th, and 5th, without result, took the 1st on the first, third, fifth, eighth, eleventh, twelfth, and fourteenth days; 9 , Anderson, took 30th first and second days, without symptoms, then took the 25th on third day; 9 a , same, took same dose once; 9 b , same, three weeks later, took 2d cent. on first and second days; 10 , Gallup, took a dose of 5th dil.; 10 a , same, repeated; 11 , T. F. Allen, proving on a man, aged thirty-five, took one dose of 30th on first, second, third, seventh, and eighth days; 12 , same, an unmarried woman, aged twenty-six, took 30th on first, second, fourth, fifth, seventh, ninth, tenth, and thirty-sixth days; 12 , same, subsequent proving, a dose of 30th dil. first, three doses second, one on the third and fourth days; , Dr. John S. Linsley, MS. to Editor, proving with a dose of 30th, subsequently repeated; (Nos.

14 to 18 , provings by Prof. S. A. Jones, MS. forwarded for this work.); 14 , J. O. Garmon, aged thirty-two, weight 172, took 10 drops of 2d dec. dil., 2 A.M., first day; 12 drops, 9 A.M., second day, 20 drops third and fourth days, 16 drops fifth day, 25 drops sixth day, 30 drops seventh day, 25 drops eighth day, 20 drops ninth, tenth, and eleventh days; 15 , J. A. Baker, took 10 drops of 1st dec. dil. morning of first, second, third, fourth, and fifth days, 15 drops sixth day, 10 drops seventh day, 15 drops eighth, ninth, and tenth days; same, three times, eleventh day; 20 drops, three times, twelfth day; 25 drops 9 A.M., 30 drops 1 P.M., and 20 drops 6 P.M., thirteenth day; 16 , J. D. Baker, aged thirty-seven, took 10 drops of 1st dec. dil. daily for ten days, same twelfth day, 20 drops thirteenth and fourteenth days; 17 , E. E. Adams, took repeated doses of 1st dec. dil. for sixteen days (usually four doses a day), 10 to 40-drop doses; 18 , Geo. A. Taber, aged twenty-three, took 1st dec. dil., 8 P.M., first day; 10 P.M., second day; at 12 M., 2 and 3 P.M., and 20 drops at 4 P.M., third day; 18 a , same, twenty-five days after last dose took 20 drops at 9 P.M., first day; 20 drops of 2d dec. dil. 8 A.M., and several times during the day pellets saturated with the 1st dec. dil., second day; pellets of 1st third and fourth days, two powders of 1st dec. trit. eighth and ninth days; 18 b , same, took 3d trit., 10 grains, 7 and 9 P.M., first day; 6.30 A.M., second day; 10 grains 2d dec. trit. 3, 6, and 9 P.M., second day, and 6.45, 9.30, and 11 A.M., third day; 10 grains 1st dec. trit. at 2.15, 4, and 9 P.M., third day; 20 grains 10.15 A.M., 10 grains at 3 and 6 P.M., fourth day, and 1 P.M., fifth day; 20 grains 4.45, fifth day; 30 grains 7.45 A.M., 4.45 P.M., sixth day; 20 grains 8.30 A.M., seventh day; 40 grains 10.15 A.M., eighth day; 20 grains at 9 and 11 A.M., ninth day, and at 10 A.M., tenth day.

MIND

While enjoying the society of gentlemen, the idea of marriage seemed unendurable, 12a.
Low spirits (second and twelfth days), 15.
A great desire to be alone (eleventh day), 16.
Very irritable (after third dose, thirteenth day), 15.
Great indifference and lassitude (fourth day), 9a.
Great indifference; lack of will-power to undertake anything (fourth day), 9.*
Disinclination for mental or physical work; desire to sit still; aversion to talking or movement, with the headache (second day); dulness and indifference; disinclination to talk and study; takes no interest in surrounding things (third day), 10.
Can't collect thoughts at all or study (fifth day), 4.
During the day could not keep my thoughts to study; I could read for a little time, then my mind would seem to be played out (sixth day), 13a. [10.]
Prostration of mind after writing for a time (eighth day), 18b.

HEAD

Vertigo.
At 6 P.M. vertigo, with nausea, on least motion; at 9 P.M., vertigo and nausea , with the intense pain in frontal region and vertex; could not sit up; greatly aggravated by even raising the head (second day), 6a.
Vertigo worse, in the evening (thirteenth day), 17.
Vertigo, on stooping or bending of the head and on lying down (eleventh day), 17.
Dizziness and vertigo, lasting half an hour, worse when rising up from sitting position, at 12 M. (thirteenth day), 8.
General Head.
Head felt congested (eleventh day), 17.
Sensation of fulness and heaviness of the head, with disinclination for mental or physical work, at 12 noon; fulness and heaviness increased until 2 P.M., when it developed into a severe throbbing headache; worse on the left side, but chiefly in the left eye and occipital region markedly aggravated by going upstairs, which causes an intense throbbing pain in the eyeball; headache relieved at 4 P.M. (second day); fulness and heaviness of the head, followed by throbbing pains in the eye and occiput (left), but not as marked as before (third day), 10.
Heavy (fulness) dull pressing pain in the head, as if full of blood (after nine hours), 4a.
Fulness and heaviness of the head, with disinclination to do anything (after four hours); headache increases, and finally develops into an intense throbbing pain in left side of the head, chiefly in the eyeball and forehead, and extending backwards to occipital region; better from keeping quiet; worse from motion, and greatly aggravated by going upstairs, 10a.
Heaviness of the head, alternating with a sensation of emptiness (after half an hour), 1. [20.]
Head feels heavy (first, second, and third days), 15.
Head feels dull and heavy (after seven hours, twelfth day), 8 ; (third day), 11.
Dull heavy feeling in the head (third day), 6a.
Head feels as if falling forward (after four hours, fifth day), 7.
Headache of a heavy blinding dizzy character, with great fulness; head feels as if it would burst open; head feels as if too small; pains mostly in the vertex and frontal regions; stooping aggravates the pains, and causes vertigo; headache comes on at 9 A.M., and steadily increases until I go to bed; scalp sensitive to touch; sore aching in infraorbital region (after one hour, fifth day), .

EYE

Bright yellow color of the sclerotic, skin, and urine (second morning), 1.
Eyes to-day markedly yellow, being stained by the acid (seventh day), 18b.
Yesterday I observed a slight dryness of my eyes, and a slight tingling or smarting, worse by constant use and lamplight. This morning there was some thick acrid matter in the corners of my eyes, worse by constant use and lamplight (ninth day); eyes smart and are dry, same acrid mucus in corners (tenth day), 17.
On waking, and for an hour afterwards, eyes felt as though there were sticks in them; inflammation of eyes has partly subsided (eighteenth day); felt all the evening as though there were sticks in them (twentieth day), 18a.
Sensation as if sand was in the eyes, with smarting pain and acrid tears (fourth day), 7.
Eyes feel dry, as if full of sand (seventh day), 12. [110.]
Eyes have felt throughout the proving as if dry, and inner surface of lids feel rough (tenth day), 12.
Awoke with sharp stinging pains in both eyes, at 7 A.M. (sixth day), 7.
Eyes feel sore (tenth day), 16.
Eyes feel worse on moving them, or turning them upwards (fifth day), 4.
Gaslight hurts the eyes (after ten hours), 4a.
Orbit.
Pressure over both eyes, worse from studying and motion, better from sitting still (after eleven hours, eleventh day), 8.
Pain over right eye in supraorbital region, sharp and vibrating, stopping a moment or so, and beginning again (lasted half an hour), (after five hours), 7.
Dull pain in the supraorbital region, coming from the occiput (after four hours), worse from movement and stooping (second day), 8.
Dull, heavy headache in supraorbital region, as before (after six hours, eighth day), 8.
Slight pain in supraorbital region and in the back of the neck (after three hours and a half), 5. [120.]
Severe aching pain in the left supraorbital notch, at 6 P.M. (eighth day), 5.
Head feels disagreeable and sore, especially the supraorbital region, at 5 P.M. (second day), 6a.
Dull pain in supraorbital region (sixth day), .

EAR

Ears began to burn and look puffy, with a sensation as if worms were crawling on them; these symptoms lasted two hours (after six hours), 4.
Burning sensation in external ears, with the headache (first day), 16.
Pain behind the right ear, running down right side of neck (after four hours, seventh day), 11.
Buzzing and hissing in the ears (after half an hour), 1.

NOSE

Bleeding of the nose (right nostril), with heat and congestion of the head (after six hours and a half); bleeding of right nostril again (after seven hours and a half, fourteen hours), 5.
Nose filled with mucus; can breathe only through the mouth; relieved by going into open air (third and fourth days), 7.
Small furuncle in the left nostril, 10a.
Stinging pain in right side of nose (after four hours, seventh day), 11. [160.]
Sensation as if something were pressing greatly on the bridge of the nose (fifth day), 10a.

FACE

Tingling sensation of lips (after thirty minutes, first day, after one hour, second day), 14.
Irregular dull pain in inferior maxillary bone, with beating in molar teeth (after two hours and a quarter), 14.

MOUTH

Saliva white, frothy, and stringy; hangs in long strings to the floor (eighth day), 4.
Taste sour; bad taste in mouth (after four hours fifth day), 7.
Sour bitter taste in the mouth (third day), 7.
Bitter taste in the mouth (second day), 6a.
Bitter taste in mouth, with great thirst (twelfth day), 16.
Bad taste in mouth of gas (fourth day), 7.

THROAT

Throat sore, feels rough and scrapy on swallowing, better while eating; feeling of soreness only felt on empty deglutition (eighteenth day), 18a . [Took a dose of Cocculus 30/x to-day, for throat.] [170.]
Throat sore, worse on the left side, a rough scrapy sensation on swallowing; better after eating, worse after sleep (seventeenth day), 18a.
Sore throat; disagreeable sensation back of an above soft palate, at 10 A.M. (second day); still continues with great debility (third day), 9a.
Throat feels raw, scraped, stiff, and hot, as if burnt; throat red; collection of thick white mucus on tonsils; great difficulty in swallowing, with sensation as if throat would split open (eighth day), 4.
Raw feeling in the left side of the throat, extending from behind forward to the submaxillary gland; worse when swallowing (second day), 6a.
Rough, raw, scraped sensation in the throat (left side), (second day), 6b.
A feeling as though a plug were in the throat, while swallowing saliva, also immediately after swallowing (fifth day), 18a.
Throat dry and husky (fourth day), 7.
Sensation as if something was in lower part of œsophagus (second day), 4a.

STOMACH

Appetite.
Appetite increased till to-day; have no desire for any kind of food, though I eat as usual, but without relish (eighth day), 14.
Very hungry, in the evening, obliged to eat (eighth day), 12. [180.]
Appetite poor, disgust for food (eleventh day), 16.
No appetite for breakfast; could not eat anything (eighth day), 12.
No appetite (third day), 9a ; (fourth day), 9.
No appetite; disgust for food; at noon (second day), 4a.
No appetite; aversion to food (second day), 6a.
Thirst.
Great thirst, with bitter taste in mouth (twelfth day); thirst continues (thirteenth and fourteenth days), 16.
Very great thirst for cold water, which is drank in large quantities without relief (eighth day), 4.
Some thirst (eleventh day), 16.
Some thirst with the headache (first day), 16.
Eructations.
Frequent eructations (third day), 15. [190.]
Sour eructations of gas and ingesta (after eleven hours and a half, third day), 7.
Intense raising of wind (tenth day), 16.
Bitter eructations after breakfast (second day), 4a.
Nausea.
Awoke at 5 A.M., with a deathlike, faint, nauseated feeling in stomach and abdomen, aggravated on rising and moving around; went back to bed, fell asleep, and on waking a second time, experienced the same sensation as on first waking (eighth day); awoke with the nauseated feeling this morning, but not so bad as yesterday morning (ninth day), 12.
Nauseated faint feeling at epigastrium most of the time (eleventh day); occasionally throughout the day (twelfth day), 12.
Nausea, accompanied by intermittent griping pains in the epigastric region, continuing until night (second day), 10.
Nausea (second day), 4a.
Nausea followed the dry cough (after three hours and a half), .

ABDOMEN

Umbilicus. [210.]
Shooting pain through left umbilical region, from before backward (after nine hours), 14.
During the evening, some pain in umbilical region (third day), 14.
Quite a sharp pain about umbilicus, on left side (seventh day), 14.
Stitches through the right side in region of liver; seem to be mostly in the muscles (second day), 9a.
General Abdomen.
Fulness of abdomen (after seven hours), 14.
Much flatus, in the evening (third day), 14.
Flatus during the day (eleventh day), 14.
Wind in the bowels passed up and down, not marked (sixth day), 6b.
Pass a great deal of wind from the bowels on moving (third day), 7.
Flatus, with much rumbling in abdomen (seventh day), 14. [220.]
Rumbling and much flatus (fourth day), 14.
Rumbling in the abdomen, with crampy pain and flatus (after three hours, third day), 9.
Rumbling in small intestines (after one hour), 14.
Awoke at 7 A.M., with dull, rumbling, and coliclike pains in the abdomen (sixth day), 7.
Rumbling pain in the abdomen (after four hours, fifth day), 7.
Awoke with pain in the abdomen, and strong erections (third day), 7.
Crawling-stinging pains in abdomen (fourth day), 7.
Some pain in abdomen and neck of bladder (sixth day), 14.
Pain in bowels, lasting all the forenoon, with very little headache; pain in bowels less than usual (after third dose, third day), 17.
Hypogastrium and Iliac Regions.
Occasionally, all day long in hypogastrium, a sensation of giving way (second day), 12. [230.]
A slight vacant and sore feeling in hypogastric region (first day), 12.
Slight colicky-like pain in lower part of large intestines (second day); colicky pains worse (third day), 17.
Severe pain in the left inguinal region, on walking, and aggravated by going upstairs (after eight hours), .

RECTUM AND ANUS

Sharp pain shooting around the anus, at 9 P.M. (thirty-ninth day), 12.
Stinging and itching at the anus during and after defecation (second day), 5.

STOOL

Diarrhœa.
Diarrhœic stool, with burning and smarting at the anus (fifth day), 6b.
Four thin stools, with great prostration, 3.
Stool twice before 9 A.M., like gruel, slightly yellow or yellowish-gray (third day), 17.
Stool rather copious, oily, yellowish (after one hour); repeated (after two hours); again (after two hours and three-quarters), 1. [240.]
Stools loose, light-colored, with cutting and smarting at the anus, during and after defecating (second day), 4a.
Stools light-colored, and passed with much burning and smarting in the anus, continuing an hour afterwards (eighth day), 4.
Soft, light-colored stool, passed with much straining (sixth day); soft stool, with tenesmus (tenth day), 8.
Scanty, soft stool, with burning at the anus, at 3 P.M. (second day), 6.
Small, ineffectual, soft stool, followed by drawing up of the anus, and accompanied by some tenesmus (third day), 9b.
Stools shoot away in soft plugs, followed by much flatus; bowels move very easily (after eight hours, second day), 41.
For sometime had been quite constipated, but now have a passage every day (seventh day), 11.
Bowels continue regular, passing easily at night and morning; passages very quick, as if greased, followed by much wind; stools have a strange odor, but not disagreeable, rather a sweetish smell, as of boiling sap (seventh day), 14.
Constipation.
Bowels constipated; only one difficult passage to-day (eighth day); very much constipated in evening, no movement of bowels; pressing-down sensation in rectum, with desire for stool, but could pass nothing (ninth day); bowels regular (eleventh day), 14.

URINARY ORGANS

Bladder and Urethra.
In the evening, a sharp pain in region of bladder, worse on the right side, lasting only a few seconds (fourth day), 18a. [250.]
Some pain in region of bladder and in abdomen generally (fourth day), 14.
Burning during urinating, and after (second day), 5.
A sensation of jerking drawing in the urethra (after second dose, thirteenth day), 15.
Slight pain after micturition (twelfth day), 17.
Micturition.
During the morning more frequent micturition than usual (fifth and sixth days), 18b.
In passing urine it kept dribbling after I got through (second day), 18a.
Urine.
Urine profuse (second day); urine had become scanty (sixth day); dark-yellow, with strong odor (eighth day), 16.
Increased flow of pale urine (second day), 15.
Increased flow of urine (fifth, eleventh, and thirteenth days), 15.
Urine increased, light-colored; specific gravity, 10.23 (ninth day). Before the proving, it had given acid reaction; specific gravity, 1020, 5. [260.]
Urine profuse; color normal; very hot when passed, accompanied with burning pain in urethra (fifth day); urine passed with burning, scalding pain (seventh day), 4.
Urine increased and of a light-amber color (eighth day); increased and of a light color, at 7 P.M. (ninth day); still pale and increased (twelfth day), 8.
Urine yellow in the morning, and of an increased quantity during the day (twelfth day), 15.
Urine continued yellow for some time after discontinuance of drug, 15.
Urine dark-red, in the evening (third day), 14.
Urine dark, specific gravity, 1030; indications of sugar; the test was good with the copper solution, also by fermentation test (fourth day); very highly colored (fifth day), 14 . [As I have not been able to get such testimony from any other prover, I hold his evidence sub judice . -S. A. Jones.]
Urine dark, high-colored; specific gravity 1025 to 1028; quantity about normal; urination followed by burning (fifth day), .

PICRICUM ACIDUM. SEXUAL ORGANS

Male.
Terrible erections, with restless sleep (first night); long-continued and violent erections, all night (fourth night); erections like h---ll; violent, strong, and long-lasting, which I thought would surely rupture the penis; followed by profuse seminal emissions (fifth night); violent erections, all night ; could not sleep for them; had to get up, walk around, and bathe the parts in cold water (eighth night); sleep broken up by violent erections, lasting all night; had to sit up (eleventh night); violent erections (twelfth night); erections, with severe pain in left testicle, as if bruised, extending up the cord as far as the external abdominal rings, at 11 A.M. (thirteenth day), 28.*
This is the fourth morning, in succession, I have awoke with an erection (sixth day), 18a.
Awoke in the night with violent erections, which cold water relieved; returned to bed, and before an hour had elapsed, was again awakened by violent erections, applied cold water, and slept the remainder of the night (I will here remark, that I had been suffering for several months with loss of sexual vigor and entire absence of venereal desire, not having had any erections for several months, but now it is the reverse, altogether too much of a good thing), (third day), 11.
Awoke with very strong erections, and pain in abdomen (third day); awoke with emission and very firm erection, which continued about ten minutes after the emission (fourth day); terrible erections, at 4 A.M. (sixth day), 7. [280.]
Great sexual desire, with emissions (fourth night); great sexual desire, with terrible erections (fifth night), 4.
Sexual desire increased; hard erections, at night; lewd dreams, with emissions (sixth night); great sexual desire, with emissions; emissions every other night (ninth day), 5.
For two weeks following, the drug marked increase of sexual desire. After a second dose, most remarkable and intense sexual excitement, which is not allowed to be gratified by any indulgence. Amorous excitement, impelling the mind to dwell on and revel in imaginary sexual pleasure. Almost constant priapism, night and day, for seven days, impelling to amorous ecstasies and mental analysis of the physiological and psychological aspect of venery, 13.
Female.
An occasional aching pain in left ovarian region (after about four hours and a half, fourth day), .

RESPIRATORY ORGANS

Dry cough, as from dust in the throat, followed by nausea (after three hours and a half), 5.
Can get the breath only half way down (eighth day), 4.

CHEST

Chest feels tight, as if encircled by a band (after nine hours, fifth day), 7. [290.]
In the evening slight pain in left lung, which felt as though there would be a stitch if a deep inspiration was taken, but on taking one three was not (seventh day), 18a.
Numb sensation in lower part of sternum, a symptom experienced much when living in a malarious country (fourteenth day), 17.
Dull stunning pain in the chest, with twitching in the throat, at 9.30 A.M. (second day), 7.
Pain, commencing in the right side of the chest, extending across the left (after twenty minutes, seventh day), 11.
Quite sharp pain under right clavicle (after four hours, second day), 14.
(Sharp pain in both sides of chest, worse in left, had been subject to such pains for several months), (second day), 11.
Twitching of muscles over eighth and ninth ribs (left side), (eighth day), 5.
Muscles on left side, over tenth and eleventh ribs, commenced to throb and jerk, which lasted from 6 till 11 P.M. (after two hours, fourth day), 4.
Heavy throbbing pain under tenth and eleventh ribs, on left side, at 11 A.M., which lasted till noon, then changed to the region of the kidneys, and continued till 2 P.M., when they extended downwards into my legs, especially the left (second day), 4.

HEART AND PULSE

Palpitation of the heart (first, second, third days, after first dose, twelfth day, and after second dose, thirteenth day), 15. [300.]
All day long, at intervals of ten minutes, a peculiar fluttering sensation at the base of the heart; it seemed to move; it startles me for a moment, but do not think of it again until the symptom recurs; continued all evening at shorter intervals than during the day; it became very annoying (second day); a slight fluttering of the heart, in the evening (third day); fluttering at the heart (fourth day), 12a.
A slight pain at apex of heart, in the evening (tenth day), 12.
Pulse.
Pulse 70 before taking, fell to 50, when it was very feeble; in the reaction it rose to 80, 3.
Pulse 75 before taking, fell to 52, 2.
Pulse 71 (when taking the dose); 58 (after one hour and a half); 55 (after two hours); 52 (after two hours and a half); 48, small, feeble, and difficult to feel (after three hours); 60 (after ten hours); 65 (after fourteen hours); 75 (second morning), 1.
Pulse 50, weak and small (second day), 4a.
Pulse irregular (first, second, and third days), 13.

NECK AND BACK

Neck.
Terrible pains in neck and occipital region, extending forward to supra-orbital notch, and then down into eyes, the same as before (seventh day), 4.
While lying down, in afternoon, muscles on right side of neck felt as though they would give way (sixth day), 18a.
On lying down in bed, at night, muscles on right side of neck felt as though they would give out, and neck would be dislocated. (I was lying on my right side), (sixth day), 18a.
Back. [310.]
Pains, heaviness, and weakness of the muscles of the back and lower extremities (fifth day), 6b.
Pain in back (eleventh day); continues, especially when sitting (twelfth day), 16.
Pain in back while bending forwards, extending from scapula to lumbar region, on the right side (fifteenth day), 18a.
Dorsal.
Aching in the dorsal region (seventh day), 12.
Pain under right shoulder-blade, as if a sharp instrument were thrust in (after four hours, seventh day), 11.
Burning along the spine, worse from trying to study, better from motion (after third dose, twelfth day), 15.
Very hot feeling in the lower dorsal and lumbar region (first, second, and third days), 15.
Lumbar.
Heavy dull pain in the small of the back, at 6 P.M. (sixth day), 8.
Severe aching pain in the lumbar region, extending down the legs, aggravated by motion (second day), 6a.
Severe, heavy, dragging pains in the region of the kidneys and back of the neck, extending upwards and downwards until they met between the scapulæ, at 2 P.M. (fifth day), 4. [320.]
Great pain between the hips, of a dull, heavy, dragging character, which descended slowly to the left leg, with severe chills, and throbbing and jerking in muscles in different parts of the body (after two hours, fourth day), 4.
Tired sensation in lumbar region and limbs, when waking from sleep, 12 P.M. (first night), 5.
Awoke at 6 A.M., with tired and heavy sensation in small of back and limbs (third day); same, at 4 P.M., with dull, heavy, frontal headache (fourth day), .

EXTREMITIES. [330.]

Weakness and heaviness of the limbs (third day), 6.
Heaviness and weariness of limbs, on walking a short distance (sixteenth day), 18a.
Rheumatic pains in the joints of extremities (after first dose, thirteenth day), 13.
Great heaviness in the arms and legs, especially the legs, on exertion ; legs feel weak and heavy all the time (sixth day), 5.
Great heaviness in the extremities, especially the left; legs feel as if made of lead (after ten hours), 4a.
Weakness of the extremities (fourth day), 9.
Great weakness and debility of extremities (second day), 9a.
Awoke, at 6 A.M., with tired and heavy sensation in limbs and small of back (third day); same, with dull, heavy, frontal headache, at 4 P.M. (fourth day), 5.

SUPERIOR EXTREMITIES

Shoulders feel very tired and sore, as after violent exercise (eighth day), 11.
Right shoulder feels sore and tired (after four hours, seventh day), 11. [340.]
Same sensation in both shoulders (fourth day), 9.
Deepseated pain in the right arm, at elbow-joint, between ulna and radius, continuing for several days (after four days), 9.
Shooting pain in the left arm, at elbow, extending down the arm (after eight hours, sixth day), 5.
Twitching of lower portion of biceps of left arm, lasting half an hour (after twenty-four hours); during the forenoon (third day), 10.
Shooting pains in hands (tenth day), 16.
Left hand goes to sleep, feels as if blood would stop circulating (thirteenth day), 16.

INFERIOR EXTREMITIES

Very great debility of muscular system, especially of the lower extremities, with the sore throat; unable to remain out of bed (third day), 9a.
Great weakness and heaviness of the lower limbs (ninth day), 8.
Great weakness of the muscles, especially those of the lower extremities and back (third day), 6a.
Great weakness in the lower limbs (second day), 8. [350.]
Numb sensation in the lower limbs (after five hours, fifth day), 8.
Great heaviness and weakness of the lower extremities (after eight hours), 10a.
Tired feeling in the limbs, when going upstairs (after five hours and a half), 5.
Hip.
Twitching of muscles on back of left hip, at 9 P.M. (first day), 5.
Great heaviness of the hips and legs, lasting all day (eighth day), 4.
Thigh.
Dull pain in the muscles on the anterior part of the thigh, and in lumbar region, accompanied with feeling of lassitude and weakness in the same, especially in the legs, aggravated by moving (second day), 6.
Pain in left anterior portion of thigh; can hardly flex and extend the legs, lasting fifteen minutes (after three hours, third day), 7.
Knee.
Knees feel weak (sixth day), 7.
Weakness of the legs at the knees (after four hours, fifth day), 7.
Leg.
Great weakness of legs , especially the left, which trembles (fifth day), 4.* [360.]
Legs heavy, like lead ; lifted from the floor with difficulty (left leg worse), after two hours (fourth day), 4.*
Legs felt heavy and very weak; also great weakness in the region of the hips (second day), 4.*
Great heaviness of both legs , at 9 P.M. (sixth day), 7.*
Legs dull, heavy, weak, and moved with difficulty (fifth day), .

GENERALITIES

Veins sunken and small, especially on the left side (fifth day), 4.
(A general feeling of wellbeing, a renewed vigor, in the morning, and an ability to rise much earlier than usual), 21.
Trembling of all the muscles (sixth day), 15.
Great trembling of the muscles (after second dose, thirteenth day), 15.
General debility (after second dose, thirteenth day), 15.
Weakness of muscles (fourth day), 9a.
*Tired feeling (second day), 15.
At 7 in the evening, while walking a tired feeling came over me, as though I had made some great exertion; it seemed as though my strength was all gone; legs felt heavy and could hardly go another step; feet unusually tired all the evening (third day), 18a.
Get very tired on the least exertion (fourth day), 18a.* [390.]
On taking a short walk, in the afternoon, find that I am more than usually tired (fifth day), 18a.
Lame and tired sensations all over the body (sixth day), 7.*
Very tired, lame, and weak sensation, when arising from bed (eighth day), 4.
Very tired on going upstairs (sixth day), 5.
On walking down town, am more tired than common (seventeenth day), 18a.
Awoke at 6 A.M., feeling tired and unrefreshed (fifth and seventh days); awoke at daybreak, feeling tired and heavy (ninth day), 5.
General dull feeling (tenth day), 14.
*General sense of lassitude (after four hours), 8.
The excessive languor began to return and unfitted me for my daily work, so I discontinued the medicine (fourth day), 12a.
Disagreeable feeling generally; lassitude (eighth day), 14. [400.]
Excessive languor throughout the day (the weather may, however, account for that), (fifth day); with a weak feeling in sacral and lumbar regions (seventh day), 12.
Excessive languor (tenth day), 12.*

SKIN. [430.]

Yellow color of the skin persisted for nine days, 3.
Yellow color of the skin, lasting for a week, 2.
Small, painful, reddish elevations like furuncles around the mouth and face; when opened they exude a thin clear serum, which soon dries into a transparent scab; they then become pustular, and very painful, and contain a thick, opaque pus, like condensed milk (eighth day), 4.
Small, reddish elevations, resembling furuncles, on the face, which become pustular, and are accompanied by burning, stinging pains when touched (ninth day), 5.
Have had pimples on the face and neck for several years before taking the drug. On the next day after last dose I noticed they were remarkably increased in number and size, 18.
A sensation as though the skin was drawn tight over the epigastrium (eighth day), 18a.
Itching of body during night (sixth day), 16.

SLEEP

Sleepiness.
Drowsiness; slept an hour this afternoon, after which I felt better (after second dose, thirteenth day), 15.
Gaping quite frequently while in church (fifth day), 18a.
Can't keep the eyes open in studying (after four hours); very sleepy; can't keep my eyes open, at 9 P.M. (eighth day); very sleepy and tired, at 9 P.M. (after seven hours, twelfth day), 8. [440.]
In the evening great sleepiness, which was relieved by walking in the open air (thirteenth day), 18a.
Sleep sound, but unrefreshing (second day), 5.
Sleeplessness.
Could not get to sleep last night for a long time, from ideas crowding upon the mind (ninth day), 18a.
Sleep very restless, until 12 (fourth, fifth, and seventh nights), 4.
Sleep restless, until 11 P.M. (fourth day); till about midnight (sixth day); restless and tossing, till 12 (eighth night), 5.
Sleep restless, with terrible erections (first night); sleep restless (fifth and twelfth nights); sleeplessness all night (fourteenth night), 8.
Sleep restless, tossing until 12, then fell into a heavy restless sleep; awoke unrefreshed (after ten hours), 4a.
Awoke this morning an hour earlier than usual, and dozed until time to get up (seven), (ninth day), 14a.
Awoke at 3 A.M., and found it difficult to go to sleep (seventh day), 16.
Dreams.
Was dreaming constantly during the night, dreamed I was pregnant (fifth night), 16a. [450.]
Dreaming all night (fourteenth night), 8.

FEVER

Chilliness.
Severe chills, with the pains between the hips, and with the throbbing and jerking in different muscles (after two hours, fourth day), 4.
Extremities cold (after ten hours), 4.
Cold extremities decidedly marked throughout the whole proving, 9b.
Coldness of the hands and feet (fifth day), 6b.
Great coldness of the feet (after two hours, fourth day), 4.
Heat.
Fever; great chilliness; can't get warm; followed by cold, clammy sweat; chilliness predominates (second day), 4a.
Slight fever (tenth day), 16.
Slight fever, with the pain in vertex (second day), 16.
Heat in head (first, second, and third days), 15. [460.]
Head feels hot (after twenty minutes, seventh day), 11.
Heat and congestion of the head, with the nosebleed (after six hours and a half), 5.
Forehead hot (after seven hours and a half, fourth day), 6.
Great heat in the right side of head (after second dose, thirteenth day), 15.
Heat in lower dorsal and lumbar regions (after second dose, thirteenth day), 15.
Sweat.
Profuse perspiration, 3.
Profuse cold clammy sweats, with great chilliness (fifth day), 4.
Cold clammy sweat of feet, in evening (seventeenth day); feet cold and sweaty all day (eighteenth day); cold clammy perspiration in the evening (twentieth day), 18a.
Cold clammy sweat of hands and feet, in daytime (thirteenth day), 18a.
Cold clammy sweat of hands (fourteenth day); in the forenoon (sixteenth day), 18a.

CONDITIONS

Aggravation.
( Morning ), 8 A.M., headache in vertex; on waking margins of lips red; agglutination of eyelids; on waking, nausea; faint feeling at epigastrium; while eating breakfast, dull pain in cardiac region; on waking, pains abdomen; 6 A.M., awoke with tired, heavy sensation in small of back and limbs; on awaking, pain in legs; renewed vigor; on awaking, tired feeling; on rising, soreness and lameness of left side.
( Forenoon ), 9.30 A.M., pain in chest, 10 A.M. to 2 P.M., the symptoms; cold clammy sweat of hands.
( Noon ), On rising up from sitting position, vertigo.
( Afternoon ), Headache; 5 P.M. pressive headache; 3 P.M., pain in forehead; headache in vertex; pain in right and lower side of occiput; 6 P.M., pain in left supraorbital notch; pain in small of back; 2 P.M., pains in region of kidneys and back of neck; 4 P.M., tired heavy sensation in small of back; pain in calf of right leg.
( Evening ), Vertigo; head symptoms; 7 P.M., frontal headache and vertigo; 9 P.M. pain in frontal region and vertex; 6.30 P.M., on going into open air, contracted sensation of left hemisphere of brain; heaviness of eyelids; 9 P.M., pain around anus; pain in left lung; 6 till 11 P.M., throbbing in muscles of left side; pain at apex of heart; 9 P.M., twitching of muscles on back of left hip; heaviness of legs; symptoms; 9 P.M., sleepiness.
( Night ), 12 P.M., on waking from sleep, tired sensation in lumbar region; pain in leg; itching of body; until 12 P.M., sleep restless.
( Banding head tightly ), Pains.
( Binding head ), Vertigo; headache in vertex; stitch in small of back.
( While bending forward ), Pain in back.
( Bowing the head ), Headache.
( On exertion ), Heaviness in arms and legs.
( During and after defecation ), Stinging and itching in anus.
( Going upstairs ), Headache; pain in left inguinal region; tired feeling in the limbs; tired feeling.
( Lamp light ), Pain in eyes.
( Strong light ), Pain in eyeballs.
( ), Vertigo.

PICRICUM ACIDUM.