Kreosotum

Volume III — Main text

KREOSOTUM.

A product of distillation of wood tar. Exact composition unknown,

1. Provings, — i. Dr. Hartung, set. 40, took, 8 a.m., 3 dr. rubbed up with 3J augar. Eructation for J h. Increased peristaltic action with discharge of* flatus. After i h., cough with expectoration of gelatinous mucus. After I h., restlessness of whole body, all limbs vibrated. After 2 h., vertigo, all goes round with him. Gnawing feeling of hunger. Prickling pain in bowels. After 5 h., slight pain in forehead. After 24 h., rheumatic stiffness of nape. {A. h. Z., xii, 33.)

2. Immisch, medical student, act. 18, took, 8 a.m., 1 dr. All d. as if stupefied. Dull pain in r. side of head. Shooting pains in abdomen. {Ibid,)

3. Lange, chemist's assistant, set. 22, took 8 a.m. 1 dr., and 2 d. later

2 dr. at 8 and 10 a.m. Chilliness all afternoon. Slow pulse, 47, for 2 d. Beating in head. Tearing pains in crown, in afternoon. Dull pressure in eyes. Shooting pain in 1. eye for J h. Pale face. Taste of cubebs and cold feeling on tongue. Violent drawing in 1. forearm. Soon, violent eructation. After 5 m., whirling vertigo in crown lasting 5 m. After 1 h., hammering pain in crown. After 8 h., violent throbbing constrictive pain in r. side of chest, lasting till he went to sleep. After 24 h,, blue rings round eyes. After 36 h. exhaustion and weakness. [Ibid.)

1. Koch, chemist's assistant, xt. 17, took, 8 a.m. and 9 p.m., i dr. and 2 d. later, 10 a.m., 2 dr. Slow pulsCj fell from 81 to 63. Immediately, pressure over r, eye for I h. Soon vertigo, i h, after e. dose, pressure over both eyes, lasting f h. After 12 h., blue rings round eyes. Restless sleep. Repeated cpistaxis. [Ibid.)

2. HeiNEMANN, shoemaker, xt. 33, took for caries of superior maxilla, Kreos. gtt. iv, Sp. vin., 3J, Aq. distil, giij, m. and e. 15 dr. He also drew into nostril a portion of a lotion made with Kreos. gtt. xx, Sp. vin. ^'^ss, Aq. distil. 3^U' ^^^^ bloated face, white furred tongue, constipation for 5 d. Scanty and painful discharge of urine. After

3 d., dizziness so that he could not walk or stand long. Blue rings round tycs. Anorexia, distension of abdomen. After 4 d., large, painful, protruded piles. After 5 d., general weakness and faintncss. After 6 d., oedematous swelling of feet. {Ibid.)

1. SuNDERSTEDT, ropcmaker, aet. 55, had recently been castrated for scirrhus of testicles, took m. and e. i dr. Drawing in whole body, stupefaction, vertigo ; pressure over root of nose for 10 h. Epistaxis. (Ibid.)

2. Dr. Syrbius, aet. 38, took, 8 and 10 a.m., 2 dr. Slow pulse all d., 60. Pressive pains in eyeballs, especially r., felt all afternoon as if he must tear out eyes, changing in e. to throbbing pain in r. eye. Taste of cubebs with cold feeling on tongue. Dull throbbing pain in 3rd upper molar, which is becoming carious. Dryness in fauces, it feels stuck together, all afternoon. Burning in ccsophagus, great appetite. Desire for tobacco at unusual time. Pressure in rectum, causing urging to stool, when only Batus was discharged. Dull pain in chest for I h. at noon. Rheumatic stiiihesi of nape all afternoon. Dull

pain behind I. icapula for i h. Pmsive pain 2 inches Pain of r. shoulder when moving it^ all d. Dull, dmott gnawing in r. humerus, with lame heaviness of upper arm. Piinnil drawing in 1. forearm along ulna. Immediately (after 2nd dote) shooting teanoc pain in 1. eye lasting } h., recurring after i) h., but sotng offiocMa ana alternating with transient tearing pain in r. eye. After a m. whiiling vertigo lasting ^ h.j weight in chest with flying stitches. After | h^ backache, tearing pain in 1. temple. Slight pain deep in forehead, wl d. Pressure over both eyes, worst over r. for 5 h. Eructation of air (aftsr 2nd dose). Whirling vertigo. After } h., throbbing pain in a Hnall spot, behind pectorales minores. After i h., obtuse pain Dehind r.acapala, with feeling of a peg sticking in there, sometimes throbbing, lasting afl d. After 3 h., fulness and tightness of chest, causing him to bteadie deeply, lasting several h. After 4 h. (2nd dose), phlegm in iarjrax making him cough. After 6 h., chilliness, earache (also after 10 and 24 h.). Pain in T. tonsil when swallowing. Dull pain in I. iliac lasting i K, recurring 4 h. later. After 10 h., obtuse gnawing in outer side of 1. thigh and leg, worse when sitting. {Sid,)

1. Dr. EicHHORN'took Kr. from February 15th to April aoth^with few interruptions. He began with 3X, then 2x, which produced hardly any effect, then he took ix, 5 to 50 dr. pro dosi, once or times a d. The primary symptoms were : nausea, inclination to flow of water into mouth, slight retching, pressure in gutric _ empty eructation, pressure over hypogastrium, pinching, discharge of flatus with relief. The following symptoms occurrra frequently : pressive pains in one or both temples, sometimes pretty severe, preaauie and tension in forehead up to crown, confusion of head with slight vertigo, frequently out-pressing or dull shooting and also ringing in ears. All these symptoms lasted but a short time, from some m, to ^ ' dis

h., most of them disappeared at once in open air. When he had the drug 3 weeks, the following symptoms in addition were nharrwid. Though usually constipated, a stool every 2 to 4 d., after the 3 proving became quite the opposite, had a copious, soft, pappy stool once or twice a d. At same time had uneasinesS| and urging in rectum, which was only relieved by stool. Also si more from flatus, which came away with stool and was very ill-ameUii^ After a few weeks became distinctly thinner and the hair grew muS greyer. On March 19th, i.e. 5 weeks after commencement wi proving, observed a pimple the size of a pea on r. spina scapulari^ painful from pressure of clothes ; in 3 d. it had changed to a which soon fell off.— 20th. Observed on r. lower eyelid a tender spot, which next d. was swollen and formed towards ii canthus a projection the size of a hemp seed on a whitish surface ; the surrounding conj. palpebralis was highly reddened, the lid externally bluish red and swollen ; in e. there were shooting pains in the affected part. — 22nd. Herpetic vesicles commence to form under nose, without previous catarrh. A small pustule appears in the fold of the r. ala nasi. The pimple on the eyelid continues unaltered till the beginning of April, when, on account of catarrh, the proving was interrupted for 8 d*. bj which time the redness had disappeared. (Zeitsch, d. rer. d. hi Oesterr.^ ii, 24. 1857.)

1. Wahle proved drug on 3 healthy girU, ^ married women, and 2 men. None of the pruvers took more than 1 dr, of itr. 5 to 10 dr. of ist dil. cauwd noteworthy symptoms. Some experiments were made with the ind and 3rd dils., which also caused symptoms. In the schema ihe provers are not distinguished, and the doses are not given.

a. Without indication of time : — Whirling in head ; if she rums quickly, she is like to tall. Thoughts leave her easily, they fly away. Wcakncsn of memory, her thoughts leave her. Headache, a* if she had drunk too much the previous day, — like a board before forehead, — with weak memory. Headache, a^ if she had been intoxicated, all d. Mental emotions cause her to have headache. Head confused, throbbing at crown. Slight throbbing under crown anteriorly. Painful pressing in head. Out.prr?i>ting pain in centre of head. Very painful pressing under crown. Painful out-pre^&ure under 1. parietal bone. Twitching and jerking pains in upper part of r. hemisphere of brain, occurring at intervalv Confusion ot 1. side of head, with prickinij in it, which later involves upper molars. Headache with drowsiness. Tearing in bead and drawing in eye*- Tensive pain in head, aggravated by stooping. All occiput as if too full, heavy, with feeling^ as if she should fall backwardv. Headache, with heat of forehead. In middle o( forehead a continual throbbing and beating, fur several d. Tciring in whole head, on 1. side it goes through temples down into cheek, but on r. Hide i( extends only to superior maxdia. Tearing in head, with great heat of face and tearing in 1. upper molars ^ the headache commences when she awakes in m. and la^ts 14 h., the toothache intermits, but always returns, and lasts so long .«he cannot sleep all n., with heat all over body, great exhaustion, cross and lachrymose humour and irascibility over every trifle. In sinciput weight at if something would come out. Drawing shooting pains in head, going through temples into superior maxillx, with whirling feeling in head. Wakes at 5.30 a.m. with throbbing pain in forehead, heat ot face, wcarinos of legs, with formication in thighs and feet, bitter ta%te, even food tastes bitter. On stooping, rush of blood to forehead, and she feels as if she should fall forvtar^l. An ulcerative pain under occipital bone, 1. side. In centre of forehead an outward pressing pain. A twitching pulsating pain over I. mastoid process. Under centre of temporal bone an out-pressing pain. In I. temple a tearing drawing as if some parts would be squeezed our, lasting several h. Beating pain in forehead. On stooping all n;shes 10 forehead, at if everything will be forced out there. Shooting pains in r. temporal bone. Drawing pains in I. temporal bone, which involve whole head, she feels dazed in head. In I. temporal bone beating and throbbing as in a gathering linger, extending up to ciuwn and downward to middle of lower jaw, also quivcrirg and contraction in eyelids, with feeling as if they liad grown smaller. Under I. temporal bone outward^-prcsvjng pain, c. On r. side of sinciput an ulcerahve pain. The whole iorehcid is full of miliary papules, which cause shooting pain ; they arc persistent and never fill with fluid. The hair falls out very much. She feels increased heat of face with sensation as if perspiration would break out, but face keeps dry. Great heat of face during noon siesta, with throbbing in cheeks and forehead, the whole face is brownish red ; after resting >some time the heat of face goes off, but the head

f rains remain and only go off after a cup of coffee or nux vomica 30, at same time frequent call to make water tilt next noon. Constant heat of face, in the warm room she has dyspnoea, she must go into open air to avoid tainting. Tearing in r. side of face, commencing at angle of lower jaw and extending up to temple, e. Quivering of e^'etids. On eyelids and round mouth itching and smarting, aggravated by rubbing, it then becomes red ; after 8 d, the parts desquamated, the whole lasts it d. Eyehds are red and swollen. Heat in eyes, on looking at bright light the eyes water. Pressure, burning, and flashing in eyes, with heat and watering, with feeling as if something were in them j alttr these pains had lasted 5 h. she lay down, slept J h., aud on waking the eyelids were stuck together. Eyes always wet, swimming in leais Itching in eyes, she must rub them j after rubbing smarting in eyes and the white of eyes is quite inflamed, with pressure as if sand were in them. After rubbing eyes they water, the tears arc quite hot, and cause smarting of checks as from salt water. Lachryination ; when she rubs eyes they become dr)-, look inflamed, and smart and btirn. The tears are as acrid as brine. Eyes look as il she had been crying. On waking, m., the eyes weep, tears are hot and acrid. Watering of r. eye and smarting of it, whilst the lids of 1. eye quiver and twitch, afternoon. Tasting 4 h. Dim, dull

eyc«, like a veil betbre them. AU the outer eir it inflamed, dlo considerably swollen, with tenuve burning paia. In 1. coooia superiorly n from which the whole auricle becomes inflamed, twclU, is hoc to the feel»wich pain ; the whole 1. »ide of neck i» stiff, with icrmvc wan, he cannoc easily mm head towards the 1., but can to the r., slight pain through shoulder and down to middle of arm, at same time inward &shooting through all limbs, heat in fbrelMad aid pressure over eyes, as though they would be parrly closed. Single pridu as wilk a needle in interior of 1. ear. Shoots in r. ear. Itching in cart and also m laki. Cramp pain in 1. ear. A bubbling, pressing-asunder pain in r. ear. Bubblnig tad pinching in r. ear, frequently recurnng. Humming in both ears, wont in L, with hardnes!) of hearing ; sometimes the humming ceases for instants, and then she hai tingling and hiKsing in head. Indescribable oad sntcH before nose, vrirh anonxia. Nose always moi^t, »he must often blow it. Epistaxis of thin, brighc-red bloods ■. EpiNtaxis of thick black blood. Dryness of lips, upper lip desquamates, is ahms hot and ten^e. Upper lip pains as if sore, and is chapped, Diyncsi ot lips as ilFtkaj were very hot internally, no thirst. Round r. angle ot mouth cooiracti'rc ceUBOB ana burning, with feeling as it r. half of lower lip were drawn towards comer of SBanAtC^ On chin and r. cheek pustules, on which yellow, honey.like scabs ftma. At a. tearing in ramus of r. lower jaw, which wakes him up, it czteads to the cnr» awl causes shooting there. In skin under chin formication, she most rnb the plao^ hat this does not remove it. Drawing pains in gums of 1. upper jaw, the

inflamed. Jerking pains in a 1. carious lower molar, with frequent yawning. Wakas L.m. with drawing tearing in teeth of 1. upper jaw, whkh lata

up at 5 a.m. with drawmg tearing in teeth ot 1. upper Jaw,

facial muscles and temples of same side, and lasts till noon, the teeth fcci laaea m and too long. Drawing pains in all incisors, all d. Drawing pain, begiania^ in ], lower molars, then extending to upper molars ; when these pams cease tbci^ thw come into upper incisorv. Drawing pain in teeth extends over tcmpoial Slimy in moutn, must always spit much, c. Dry feeling in oeac^hagus, with at lasting some h. Scrapy in throat, Scrapy and rough in throat, rressmv in rl of throat when she swallows. Rough, hoarse voice, with scrapy fieelmg in On 1. side of throat, when swallowing, a sore pain, with feeling as if aonwthi^w woe hanging there which hinders him in swallowing. A choking, painful fieeliag den in oesophagus extends through chest to venebrae. Lust of taste. Eructation ofw after dinner, followed by spitting of filthy saliva and scraping and raw IccGu ia throat for ^ h. Sour eructation. She ieels sick, with spitting of saliva andoU^ feeling all through body, not followed by heat or thirst. On nsing, m., bekhi^waf tasteless water and mucus, with dryne%s of nose, heat in fore part ci head, aa^f aM wovild come out at forehead, cold hands and feet, with thirst. Complete an When >hc goes without breakfast she has a gnawing, followed by retching^ goes off after eating. She must dress quite loosely on account of tightnei stomach and scrob. cordis. Violent stitcnes in hean, causing him to CfT ont> often leave off for 3, 4, or 8 d., and then recur by d. as well as by n. Fam in men, &uch as often attacks her after eating sour things, it is a still pain fonni navel. Ulcerative pain in abdomen on drawing a deep breath. Painfiil

feeling in abdomen, with scanty urine. Pain intermingled with shooting

navel, as though she had eaten fruit and then drunk. Distension of abdomen, ^ jf she had eaten too much. Wakes up between a and 3 a.m. on account of contnctiva sensation in ab<1omen, she feels as li a lump lay in umbilical region and was twiMld tightly. Drawing pain in abdomen during menstruation. A still obscure fSa* In aUlomcn, which she cannot describe. Her whole abdomen is distended amt ^gH_ Distension of abdomen after menses. Stitches from abdomen down to vagina. Jifat electric shocks, recurring after some h. Cutting round navel as though she have diarrhaa, she must double herself up, it left off tor awhile and then r periodically. In umbilical region she feels a painful lump, which seems tobc together. In umbilical region a pain as h'om a chill, and as if diarrhcea would on. Painless drawing in upper part of abdomen, extending to sacrum, there caui labour-like pains, with pressing down towards lumbar vertebrx, at same time fliai of heat in face, palpitation ot heart, quick pulse, ineflfectual urging to urinatCL urine comes at last after much pressing, but is hot and scanty; after the chilliness, cannot get warm, no thirst ; these attacks came on every ^ or^ 14, h. ; they are in connection with the lachrymation and disorders of vision in^

way, that the eye-symptoms cease when the labour-like pain% come on; when the pressing ceai>es, milk4ike leueorrhtra iliops tVom vagina. When she rises eailv and sits down immediately, she gets a pres-iive pain in region ot spleen whii-h exftauKT^ her, but if she walks about wben she ri«ef in m. the pain doe^i not come ; the ftlightc^t pressure there if> painful. Prcnive pains in hepatic region and gnawing under 1. short ribs a& if a worm were gnawing their. The upper anterior lobe of liver (?) pains as if from a blow, and causes feeling of tulnes^i, so that ^he mu-it constantly raise up her clothes there. Shooting pain* in muscles of I. renal region. Tensive pain in both inguinal region* when walking. Several successive stitches in rectum during mensem, which dart iipwirds to 1. iliac region and stay there socnr time, during which she must remain standing. Sbe must go tn stool twice daily, nmtrary to custom, stools (|uite normal, 15 u^ually ron'.tipatcd. Two or 3 stools daily, not loo^e. Hard, dry lumpy stool, with much pressing, only every 3 or 4 d. Scanty urine, she passes st^arcefy halt the u«ual quantity, though she drinks more than usual. Urine in a feeble stream. Very scnaty urine. Frequent urging to urinate, but little is passed, and that is clear. Along with the diminished quantity of urine tenseness of abdomen. At n. must rise to urinate, but passes little. Frequent micturition, but only a tablespoonful of urine passed at a time. Urging to urinate towards c, and must frequently rise tu urinate at n. Chestnut. brown urine. Ill smelling, colourless urine. Hot urine, it smokes, smells acrid, and has a re<ldish sediment, Rtddish urine, with sediment. Uvine often has much white sediment. Frequent micturition at n. Frequent discharge of hot urine. Must pass water every h., and each time much clear urine pas«yes. Frequent calls to urinate, .ind each lime before doing so she has a discharge of teucorrhcea, wtiich stains her iinen yellow. Urine very hot, and scalds her between labia. When urinating burning in vulva. Urinates six or seven times daily, she has urgent calls, and much urine passes. Spasmodic pains in external genitals, lasting several fa. Smarting itching between lah<a and in vagina, she must rub, after which there % burning and swelling of labia, then itching came evtrf)' i to ^ h..and la>ted 4. d. Soreness between labia, and smarting pain. Excoriation betwixt thighs and labia, with burning and smarting pain. Violent itching and smarting between labia, she cannot refrain tVum rubbing. Voluptuous itching deep in vagina. Electric stliclic^ in vagina, which seem to come from abdomen, making her start, all d. In the m., betncen sleeping and waking, a desire for coitus, which she has not had for years. During coitus an ulcerative pain at ntck of utenis, where there is a hard lump posteriorly, less pain in these parts c, than m. During coitus both itun and wife felt burnins; pains in genitals, and the man became impotent, the next d. he had ^welling of the penis and his wife had her menses, the discharge was copious and dark coloured ; after they had continued 4 d. she had leucorrhoea, which stained the linen grey, and swelling of external genitals, with itching, eroding, burning pains. Prolapsus va^nae. A d. or two before menses eructation of tasteless white froth, if she has not this she has vomiting of mucus Three d. before menses, hearing dull. Before menses great distension of abdomen. One d. before menses a scraping and digging pain round navel, relieved by stooping forivards ; when the pain sulfides there is white leucorrhoea. Some d.beforemcnsesexcttedand restless. Mens«& 4 d, too MKjn, very profnsc tor 3 d.,then ceased i d,,and next d. came on very profuse. Menses 9 d. too soon. Menses from $ to 10 d. too soon, discharge dark, profuse, and lasting 8 d. Menses every 3 weeks, come on slightly, continue 4 or 5 d,, and are very profu*e, then for 2 to 4 d. there is bloody ichor, which smells acrid and causes itching and smarting of eenltals. During mrnses, flatus smells of rotten eggv During menses the stool and flatus remain longer in rectum than usual, she feels tneir pressure with discharge oi flatus, then her menstnial flow is very prutuse and in clots. During menses dull of hcaiing. During menses, humming and buzzing in head, with our-pressing pain, much aggravated by stooping. Duiing menses, much chilliness. The menses came on with pain in left side ot' chest interiorly and cutting pain above navel. The menstrual discharge is in clots, and very profuse. On the 3rd d. of menses she got K.r. 6 at 8 a.m., by 4 p.m. the discharge ceased without any discomfort, and reappeared at the regular time. The menses, which had ceased 4!! h., return with violent pains in abdomen, the discharge is then bright red, lasts 14 h., and then goes off" quietly. The menses, which usually are 9 d. too early and combined with much sacral pain, were very profuse, and lasted g d., were DOW scantier, lasted hardly 3 d., and were without sao^ pain. Menses not nearly so

profuse as usual. MenKfl ceuc tor 60 h., and then conw on in the ferepoow pain, aiter having flowed normally tor 5^ d. In the 5th n. of the dewhk* thi profusely^ but onlv on bark and cheiC. Three or 4 d. after menses Tiolnu tpi abdomen, especially iliac regions. Some d. after menies forcing and prewnc wards, as though they would return. Leucorrhoea of a yellowish COUNO', witll gem weakness of limbs. A woman who had never had leucorrhoet got, alter ■ ladi dost of Kr. 6, a painless white discharge from vagina, which lasted ieT«r«] d. In addition to men»es, periodical Icucorrhcea. White painless discharge from r Leucorrhtra makes whitish -yellow spots on linen the site of a sisqience^ m mbo and causes itching and erosion on external genitals. LeucorriMEn ntaitis tbe like serum, and has a putrid smell. The Icucorrhceal discharge is often quite and smells of fresh ear* of com. Leucorrhoea goes on 4 d. unintemiputdty sensation. Sneezing. Sneezing in m. Frequent sneezing* «M BOUteeH af In m., hoarstrnes-t, which eoc* off after sneezing. In m^ fnquent snct cor)-za. Fluent coryza, when the air is drawn in by nose it Iveb too initscinc ■& i^ choanx. Stuify cory^a, which becomes fluent after is h., with a acimpuiKf fon^ feeling under sternum. Cough, with difficult expectoration. Dry coun, sin scraping in throat and soreness of che<»t. Cough caused by a fccliag a* if niacai were sticking in the middle of the chest, which cannot be got rid of. Uocicr laryBx a crawling which makes her cough. During cough scrapmg in throat, ^th a inmp of thick expectoration, e. Constant cough, with great drowsiness, i h. of tigoTf^bct dry heat, during which the child continues to sleep. Cough, with WUtc^ kmIj expectorated mucus and a scrapy feeling in throat. Whooping oou^fau In As centre of chest crawling and tickling, causing dry spasmodic cough, which laaca Htfil retching come!> on, m. Whistling dry cougn. Constant easily expectt»ntefl ibocat in throat causes an uninterrupted hollow and rough -sounding cough. Cougjb with retching, but only saliva comes. Cough, with dii«harge of urine. When the u^c coughs come, the urine spurts away from her. On an asthmatic person soSv upstairs the asthmatic breathing resolves itself into an easy expectot^ttoo, —_ Dyspncea, she cannot bring up her breath, it is as if it were held fast 'm the cbca below. In the lower part of chest a feeling of weight, so that she cannot t&ahc a proper expiration. Quickly recurring oppression of chest, with some' ow^^m stitches in the middle of 1. side of chest. On inspiration a transient pain in bimj^^ ^ chest, with dyspnoea. On account of heavy feeling in middle of chctt ihe take a full breath. He must often breathe deeply. Anxious and difficult On inspiration the chest feels internally bruised, on account of which she breathe less deeply. On inspiring deeply a contractive pain in chest. Wr^^^^cm sharp stitches in centre of chest, aggravated by inspiration, thence the itktchrs sjire-nd over r. shoulder and go with a burning sensation to elbow.joint ; on rmi'^lng arm the pains are worst in snonlder. Raw pains in lower parts of chest. On pmkine o«i sternum it is painful in the middle, 2s though pressed by something hard, frit oei inspiration and then spreading to clavicle and muscles of rape. A pam^ Keliag m sternum, a^ though it was very much pressed, felt more during expiration. Wim taking a breath she felt a sharp stitch in I. side of chest, which soon went off mad came into r. side of chest. In the external parts of 1. side of chest a shoodng, whtdl has no effect on rtspiration, when at rest. In interior of r. side of chest aevefv stitches, which take away her breath. At ^ p.m. ^he had some stitches in r«. lide of chest and under r. scapula, which took away her breath and she thought she —yy fall. In 1. side of chest shooting, most observable on turning in bed. In ^nijii^i parts between ribs periodically recurring shooting pain. Painful shooting acvOM middle of chest, recurring on rising in m. and ceasing about noon. Vbtent ititi^^ in lower part oi r. side of chest, lasting several h. tCnife-thrusts in r. side of ^w^. which go off and return by d. and n., he cannot sleep all n. they are so fioleaL causing him to break out in loud groans, they are somewhat relieved by firm prmag^m on the part with the hand, but when he removes the hand they recur as violci^v Al a hemiplegic). Feeling as if milk came into breasts, which are quite soft, jatf m when nursing. Shooting in heart for ^ h. Sacral pains, which go from bdow upwards, witn heat of palms and soles, ^cral pains worse when at test, better moving. Sacral pain as if after stooping much, aggravated by movement stooping. Sacral rains as if her sacrum were broken, which extend to bcl shoulders; it feels like a band between shoulders, so that she cannot move

finger-tips which feel index a pain as if he In 1. index a paralytic Dying away o\ np«t

without pain, and can hardly stoop, all d. Violent pains in lumbar vertebrae as if ulcerated, with preshing down in rectum, zs if Baius wantrd to px^.^, but none does, during rocHKe^ j before iiien&e^ the pain*- in back were relieved by movement. One of. the upper lumbar vertebr* pains a* if ulcerated, or as if the flesh were torn away there, and when ^he standi up !.he teeU as it something would fall out there. Spasmodic drawing from lumbar venebrx, going forwards and down thighs, ju^t like true labour pain^, with great restlessness through whole body. In lumbar vertebrx pain such a» ihe usually has bcfoie mensev. Drawing tension between shoulders. Single stitcher betwixt scapulx, rapidly going and returning. Pains in shoulderi* as though «he had lain with them uncovered at n. Pains in both shoulders as if they had been pressed against sharp comers, tn back parts of shoulders painful drawing. Pinching^ pains tin innrr side of 1. upper arm. On lower part o^ r. foiearm in the muscles of ulna a painful drawing down to lingers, and out there, so that ^he cannot grasp tbing« properly with this hand, and there is a paralysed feeling in it ^ it recurs every half or whole h. Periodical pains in both clbow-joint'* as H the ligaments were drawn together and were too %hort. In lower part of I. ulna a spasmodic pain ex< tending into fingers. Drawing pains in 1. forearm extending to fingers. Desquamation ot !ikin of hands, which arc quite stiff and stark. Very agreeable warmth in palms, followed by warm sweat there in bed in m., and recurring several rime* during d. The whole r. hand is covered with papules which itch violently, the itching i» wor-ie in e., and in bed. The 1. thumb pains as if Miff and sprained. Sprain-pain in ^cond joint of 1, thumb. Drawing paim in I. " as if swollen. Drawing; pains in r. rine-fineer. In ball of I. had gut something sticking in it which is going to suppurate, pain, commencing when at rest, removed by movtmcnt.

phalanx of all fingers; they look quite white, and she has no feeling in them. In I. bip-joint a pain as if the parts were pushed out ; when he stood on r. foot the 1, leg telt as if it were too long. In region of crista ilii stitches which traverse the body. Painfulness of both cristje ilii and of lumbar muscles as though she had run a great di^tance ; this painfulness or bruised feeling extends into thighs and down to calves, when it ends like lightning, but leaves a stiffness or want of freedom in lumbar vertebrte, m. The cristse ilii arc painful when pressed on, as though *)\t had carried something heavy or hard on them. Drawing pains from head of r. femur to knee-joint, so that she can hardly go upstairs, better when at rest, lasting some d. Painful drawing mixed with shooting from thigh through legs and soles, worst in r., aggravated by movement. The posterior parts of thighs are the seat of tensive pains as though she had walked a long distance, most felt when walking and stooping. Blue spots on thighs that look like bruises. Three inches above I. knee in the fleshy parts a twitching pain when at rest. From middle of I. thigh to middle of leg the parts arc painful, as though he had tearing in them and they were still stiff on moving. Painful tension in fascia lata oft. thigh. Thiee inches above I. thigh in muscles a pain as if they were too short, worst on stooping and walking. In 1. kneejoint a dislocaiive pain so that he cannot stand on this leg alone, and always has a feeling as if it would knuckle under him. Tearing, boring, and shouting pains in ]. patella, coming in e. with a chill, and lasting all n. till m., when they go off. Under r. patella an acute pressive pain. Drawing, tearing, and shooting pains, now In r. calf, now in region of hip-joint, lasting 5 m., then ceasing for a long time, and again recurring ; the pain always comes on with great violence, making her start, at same time itching and erosion in eyes making her rub them ; afterwaids the eyes burn, and much greasy mucus comes into their inner canihi, requiring frequent cleansing. In houghs red scaly skin like tetter. On legs and knees down to toes a throbbing like a boil, worst in soles. From knees to ankles, especially in calves, painful tension when moving, not when at rest. Chilliness from dorsum of foot to above knee. Painless jerk through 1. leg ^ the foot was twitched up. Paralytic drawing through I. lower limb. A twisting-out pain on r. outer ankle when at rest. A sprain>Iike pain in I. tendo Achillis. In I. heel, when moving, a violent shoot, making her start and stand still. Weakness of 1, leg, no steadfastness in it. Legs swollen from calf to front of toes, 1, most ; the swelling is oedematous, white, but always cold and heavy, so that it requires an effort to get along. He has twitching and pinching pains in all joints. Tearing-drawing and shooting pains from heels, through soles, out at toes in e. On waking next m, the soles felt like balls when she trod on ibem.

8o

thi$ eoct off Lm. Pinchiiif paint beiv ind tha*. Cold rcct. Swcsiy Iccc ecotiofully. L. foot Mowwhat nrollcn. Hcaviactt ia Icj^ from kntc*- lo «i>kk« wte» moving, m. Wciffht in ill her Unbt with 4rawrinr««. AJJ hrr TimlM arlkr » i( bruised. All her hmtM ache at though the had cai^ht ■ wvcrt coJd. All (tiDht M bruised as though the had run a great diitaacc. A working m 9oU% lu though Ar had walked a long wajr, with great cxhanatiOD, 1. wome. Gonf -tv.jicrp t'eeCttg ia lower limbs. Feeling at if all partt of the boojrinovtii wlirn m rr^. Blows iH through body, nuking her itart, when aalccp at n. Greti ctcirrmcnt at who« body. Buming>ilcbt]W in aolc^ Towardt c, dw- ifching bccoino o viciient » almost to drive her mad. The whok bodycorcicd with Uj^ |>usiuTc« tike utnilpoa. Nettlerash'likc whrak tveafc out» latt s or ] d.^ ^n dii^ppear, during which ttmr fresh ones alwayt appear. A veticolar emption (like tnq{-bitrx) appears all ovct body, only the calvct, chctt and ftce were free bvm lhein» tbr itching r« w<mc between 5 and 7 p.in. and at n. Itching all orcr faody« the ■.-«nr>oc help K-ntrhkng, on the bodv the itching goct oflT after tcntching without Itavm^ any fen^atitifi, bui on lep and armt it is rauowed by violent burning Stir cannot i-Irep at n tor hcai, itching and burning all orer body. After midnight the wakr^s^e lacd ^ccnu toe wann, but if the puti her foot out <^ bed the it caiUeii^ Weary and wrgJc m knw limbs as if the hao walked a long way. If the hat 10 get up \ h. soi>arr tlMB imial she has a fit of faintnett that hntt a whcUe h. Stretching anJ yawning a brfiw aa a^e fit. Frequent nwning at thou^ the had not skpt at all e. Frrt^urnt /awming with chillinets. All d. yawning with watering at eyo. Vrr^ frrqurai yawniag with watering of eyct. Frequent yawning with prr%%ivr fMiin« in forehead ad uneasiness. Verv drowiy, the would like to be ahrat-ii ilrrping. Shr U %'cfy tind, and yet cannot tieep, the toilet d>out in bed all n. tiil 4 A.m., nhm the nienM» com on at regular time, then the ttept 1 h. Cannot get to »leep on ;krcouM of m(lcmie« through whole body. Waket luddenly at a a,m.at if he y>ttt callrd, aJw wv w«dc awake and had got her mcntet. Though the wakci ohai at n. the ictU quite rvM«d in the m. and it quite chcerfol. She waket up 3 or 4 timet at n. mthotjt ranvt, after turning about a little the follt atleep again. Bad klcrp. »lvr canooc finU ui easy position, the eyet are icaled up in m. Sne can teldoin get lu »lrrp hrl'ore midntghc, nas a feeling as if too tired to tlecp, with paint in all limb^. After 3 a.iD. \hr cannot rest, tosses about. Stant up in amriffht from tleep. She tlrrAni<> thttt tomcthtnr Iim happened to her children, which malet her weep and ke) very anvioua : on w^kju she was wet with svreat. Hardly atleep the has anxiciui drrain»» After mrdnigia she laughs in her dream, the knowi not why on wakiii); ; i-he Uy mthout clothes aod was cold, but did not feel chilly. A chokmg feeling in ihrcac during a drram «i q. She dreamt that the fell from a height. She drcami thai »now wa^ tailing. tbi hkt was in the open air, had her baby with her«aad wtK rhrrcforc anXiuttt. Aukioot dreams, she is followed by big men who want to ravish hrr. iilie dreamt that «|ic hi taken poison, and it much emaciated theieby. Atixioui dieains ^hc vim a muO object before her which growi alwayt larger. All n. anximtK drratnk Drrwnc o( fire which burnt brightly, which made her very anxinm 9^t\d noke her up. OrcaiM of erections and urging to urinate, and that on tryinig to du mo the }£bn» pcni» bnjJu off. She dreams of natty dirty linen. Feverish ail through h)»b(KJy, ^Kuddrringall through skin. She is easily chilled. She it alwtjnt chilly, but chirriv >u durtnc menses. As soon as she rettt the hat chilliness all thrimgh budy« Chiiline^ fVir t successive d. Chilliness betwixt dioulders and along b^ck, eanror wArm hcrvrli st the fire, during menses. ChiJlinett beginning between ^houldrn. And ^uin^r c« niuldk of sacrum, then sacral pains so that she can neither Kit nor lie, bur mini aTwnyk^ walk about, whereby the sacral pains are relieved, bur now pain occur in hipiv, wd'u into middle of^thighs and prevent her lying quietly in bed ; ihcv arc tmty rr tievi external warmth, exposure to external air increases the h'\y pairm AUrrnatr and heat with much thirst, uneasiness in all limbt, Cdntlnuuu't eouzh, wm^'i sometimes loose, but very exhautting and painful, it it excited by irritatiol. parts of chest with formication from centre of chest up to throat ; the : stomach is much shaken by the coup;h ; at tame time a prettive pain 00 l| of the top cervical vertebra, which it aggravated by touch. After the lU Internal rigor with red checfci in the warm room. Periodic flutha or cheeks become bright red, the redness is ihaiply circumicribed. Dry forcr cheeks look at if painted) all over body, without thirst, and then

8i

k

sweat i a« soon as cbis t& passed thr mo«t violent drawinff and shooting ^rral pains come on, which allow no sleep at n. and render turning in bed difficult. Small and suppressed pulse. All d. stronger puliation all through body, with a tceling a.'s if whole body waggled when at rt^t. PuUc normal, but when he h at rest he tceU it in rvery part. When sitting and walking a rc^tlesitncss and chilline» through all limbs, so that she would like frequently to breathe deeply, but cannot do w>. In m. she i& very cross. At music or anything that cxcite>cmotiont she tccls a tightness about hcan, and cannot hdp weeping. She is always excited, cr«.s, and wiU'ul. Towards e. her spirits are qiute depressed, and she despairs of ever again becoming well. She ti iick, ardently desires death.

h. Immediately, nausea a& though she would vomit, with buining in mouth. Hunger, which was previously present, goes olf for several h. After lo m., on back of tongue wur taste. After ^ h,, painful prcs>ure over r. frontal protuberance. Over r. eyebrow an obtuse pressure as with a peg, which extends to occiput. Vomiting of sweetish water, m., before food. Twitching tearmg in r. knee, when at rett. Weakness as though she had not slept enough, with warm feeling in eyes. After i h., on the street she had vertigo, causing staggering, she was as if tipsy, and had to return home j the venigo went oH^ in the room. Retching such as she used to have in the first month of pregnancy, m. Sneezes 5 or 6 times in ^ucce^sion. Feeling as if mucus stuck in throat, making her constantly hawk, after a while »he expectorates sweet-tasting white mucus. In the centre of chest feeling of weight, with dy>pnoea, so that she must often involuntarily take a deep breath. Breathing difticuli, ai tliough chest were compressed, causing her to breathe deeply. From centre of chest up to throat a burning as though brandy had been drunk, even the tongue is painful, as though it had been scalded, with heat, rcdnes& and tension of tace. In the middle ot r. side of chest, 1 inch on eternal side of nipple, a very painful and obtuse shooting pressure^ which goes through the chc>t and is felt at apex of scapula. Whilst writing a feeling of cramp in point of r. elbow, nearly preventing him writing. After 1 h., stupid and empty in head ; her thoughts leave her for instants, so that she knows nothing ^ this occurs repeatedly during d. In r. Uiac region a frequently recurring pain, which radiates upwards and downwards and extends ii\to r. testicle. She has a feeling of coryza as though the nasal m.m. would swell. A pricking pain on back of 1. hand betwixt thumb and forefinger. After some h., abdomen very much distended but sofr, with dyspnoea all d. After 1 h., pains in chest as if sternum were pressed in. She is chilly, her hands arc icy cold. Chill all over body, the skin is as if dead, and she feels aU through body as if she had been up all n. and had not slept. Rigor, with flushes of heat in face, drawing and shooting pains in both temporal bones anteriorly, pressure in eyeballs and a veil before eyes, hindering vision and making her rub her eyes, whereupon scalding and acrid tears flow, and the white of the eye looks inflamed. After j h., in r. temple anteriorly tearing and shooting, involving upper and lower molars. Painful feeling in sinciput as if sr\eral hairs were seized and pulled out, felt even next d. After 4 h., in sinciput beating as if with a hammer, and in temples shootings, which occasionally cease, but always reiur ; on stooping, feeling x^ it all would be forced out at forehead (for 1 d.). On r. side of abdomen, between navel and crista ilii, some violent stitches, which take away her breath so that she must cry outj when at work. Urine turbid. In r. palm, betwixt thumb and forefinger, an agreeable itching, lasting i h., not q^uite removed by rubbing. Chill all over body, so that she shivers, with great heat of tace, bright red checks, icy cold feet, feeling of weight from shoulders to elbows, so that she could not raise arms to head, only felt when moving, with great crossness, lasting from 10 a.m. till 10 p.m. f sle]>t well, and wa^ all right next m. A rigor of 5 h. duration, then heat of face and hand!i and cold feet, mingled with chilliness, from 2 to 1 1 p.m. After 5 h., all objects appear dim, like a veil before eyes, lasting several h. Hot, red ears, wtiich burn, as when one comes from the cold into a warm room, with cold feet. Ar 3 p.m. pain in scrobiculus cordis, as if a thread were drawn through or a small muscular nbrc were torn out, which goes through all limbs, when at rc^t. After 6 h., stupid in head, she looks straight before her, she does not know why, and hear^ and scci nothing and is quite without thought. Digging in sacrum as though .>umcthing would conic out. After 7 h., towards e., crawling in upper bronchial tubes, causing cough. After 8 h., when she wants to do something and has walked about a dozen steps, she stops and iLtva^n^

VOL. III. Vk ^^

not what she wanted to do. A «paimoilic duobnag pft'm on Innrr and lovtrr fwn of 1. clbow.joiiit, which occon in wigk6ti| f4B. FM>m r. tuber uchit dowa lo mtHk of thigh on iti outer tidt, dnwisff pain at if ia boBc. »it|) cbtUinc^B. In ifoe ^iddlr of 1. thigh a pcBctntiag twitcmnir paiOy whn at R^t. Alter j^ h^ ftpa«Hdir tr * '

drawing from hunhar rcitcbne to ||cnmli. Afbr > i h,, {inwing teaHn|(, bcgnaiaf

in middle of K}uamoat sotur^ ■"''V ihroogfa Mftplr sml I. *-'tSe of Acc» involriag

upper and lower teeth of that noc, laMiBg levcnl h. Btner u«re in throat, c, take*

away reloh for food. On iBOfinf.the wbok abdomrn U punfui i.« if ulocrwaA

going ofFbymt) theiepain»laataoii.,aBdhiadtr her from tlrrpingvreU mx tt^mthm

she must turn about frequeatl^athc then iScepi ftr a Uttle wfailf and toon wafen agu.

Mutt rise eveiy h. at a. to unnate, and each time nuch dnr urinr inaa ■ Violas

urging to urinate, she cannot ^ out of bed <pUckIv moui;h iu ^o u, with ronirac^

tive pain in vagina. Violent itching in vaguia, htir muit rub heravlf, aircrwardt

•oreness the external genttalt «wcUy bcoooe hot Mud hard, tod oa iirinating the

ragina feels sore,c. Sleep at n. distiiibed bjpitnare and burninj^ in ryr*, lin «wikc

tilfm., then goes to sleep lor a little whik and wak» wiih tyn scaled up. Aftir

]6 h., she sleeps all n. withoot COnsciowWy not mual with hrr, i\ ^uite wvll in m.

After i8 h.,from the petric fegion all thrao^ the upppr yzrt ol ibr bodf a wofkiag

and beating in all bm»d-Te«cts, wone on Boriaf. After to b„ an waking, m^ %

foetid smeU before note. On ritiag, m., rigor wirh bright rrd cptti«u». After

21 h., as if downy featheia hung ofcr eyes, nwr mg h*r wim them cafHt^ntly. Afitn

33 h., 3 d. after menses, a oontra^ve pita in vi^ns, oiaking h?r ■tan, wbcmipon a

white discharge took place from Tuina. After a^ h,* drawing pain in head, bo thai

the eyes are closed. PttiuTe nain u iincipat at it all would come out there. On r

side of head prasiTe pain, which mme to coom fiotn » rvical nitiwles. On loohii^

for a little while at an ol^ect, the eyee bcoome aont, whirh tntcrffrcs with vittois.

A jerking shooting in r. aotitngos which it tookcwhxt swollen ind \riff, and ht*

shooting pain when touched. Toagoe dean bat pate and a^ if withered, with thia

saliva in mouth, no appetite, but nmeh thint| tln«Mt always dry, m> tlut «bc onai

drink much. Bitter taMe, m. She hat appetite but nn relish ior food, ar aankc eimi

feeling of fulness, it tbourii die had alreaay eaten brgrly TisKtnru and dinension

of belly, without pain, nin in abdomen, deep down in abdumrn the pain k Ukc «B

ulcer, mixed with electric shocks in the internal aexiial organ*, which cmuik« plwhinc,

spasmodic oains in eictcmal labia, making her ttan every time the pi.in orcur^ nrcb

a periodical pressine proceeding from tacram fontardK, whh trrqucnt rail to paw

unne, but only little dear urine comet} inelfectna) urging to stool and anxiM

uneasiness through whole body, so that ^nt sweat of anxiety hiraki our cm her.

with ill humour, so tluit she feels indined to quAirnl wkh and l>eat ftonnvosiei

whtrn these attacks take place while the it seated th? mu«t rUr uf> and w«tk abam,

when the pains gooff; uis state lasts 4 d. Above- aitd ro\ind navrl a iligbt pai^

which she cannot detciibe acciuately, or such at fr>l|QW& drinking wmin aixcr ao«r

food, with ill humour, lasting ]6 h. Drawins^ tearing^ and Ahooiinj; in rcctuns, with

frequent ineffectual urging to stod; after 36 h., with much prcftiing a haid ttoal a

evacuated, when all the paint cease. When she pre*.«»3e 'tool there occur itfxa^nodic

pains from lumbar vertebrc to r. ingtiinal rmon, thry extend to r. hip-joint, and an

a great hindrance to walking. She must often iH^athc dccpty on account ot~ bearr

feeling in chc»t. The whow eztrmal chest pains as it pressed in. Drawing i«c»

pains down along coccyx to rectum and Tagiiu, whrrc they cauMr spasmodic coewiat'-

tive pains mixed with shootinn, pains dimmished by riMne up, but rrium tn fits flQw

labour pains), after tuch tttadc leucorrhoea like whey gu«hr^ i'jom her. A paralylic

pain darts like lightning to 1. hand, so that in a mftrntiit %he hu fall what «be wai

nolding. In middle of 1. femoral mutdet a pain as though sht had rrc^ivcd therv a

hard blow, worst when seiUed. She it very cross, and mu^t frequently wrrp without

cauM. After 39 h., in lower parts of ear pain composed of Keveral a '

ceeding from top df r. shoulder. After 30 h., at b^tk uf Ahouidcr*J|i

which dart through whole arm down to fineeTS) in the latter ihcy cauf.

as if gone to sleep, with insenubility and powerle-iKneivi., w thni ^be'

anything firmly in the hand, if she us no stitches she has jerking ia

creeping and heat <^ them. After 33 h.,the scapulae are painful, at if d

beaten. After 36 h., preisive pain in head, all seemed to be forcing oal

with prchsurc in eyes, extending up to crown. A digging and gn|Mag

«

navel, which goes up into throat and causes her to feel sick and inclined to vomit. On r, wde under false ribs in hepatic region a constant shooting pain for 6 h. Frequent sneezing, noK not stopped up, and yet feeU 2s if she could not breathe freely through it. Nocturnal back pains, 10 that she can hardly tie, they extend over i. hip, settle in flank, and involve I. inguinal region, v) that she can hardly raise herself up, the back pains worse when at rest than when movine. SeveraUucccssive stitches in r. ankle-joint, which radiate out to toes and involve the whole foot. When walking, heaviness of feet. At 9 p.m., chill, first tn feet, then in back, head, and arm when she is chilly up to fingers, with feeling as if those pans were cold, which is not the case, lasts 1 m. After 4* h., spasmodic pains in rectum, which extend upwards to iliac region, so that she must walk bent double and must &it down carefully. After 48 n,, obscure pains in whole abdomen, not increased by touch. Under I. mamma several successive stabs, as with an awl, which radiate upwards and over r. mamma, and severe shootings under r. scapula, hindering breathing and lasting 5 ra. After this pain under I. mamma has lasted ^ h., it darts thence like a sharp knifethrust across scrobiculus cordis towards r. side of chest, r. side of abdomen through thigh and leg, and ends in ankle, all like an electric shock, p.m. On lower part of upper arm on its inside pain as if she had had a blow, only felt on being touched. A quarter of an h. after rising in ra., the first a phalanges of all fingers go to sleep, there is formication in them Tike ants, and they arc quite tvhite like dead hands, no feeling in r. index. Weakness in knee>joints, as though they would knuckle under him, when moving, for i h. In r. ankle shooting, worse on moving. From 9 p.m. till 1 a.m. she lies awake in bed with sacral pains internal chilliness, and strong pulsation in head, and tosses about. She is sacf, and wishes constantly ro weep. After ft h., burning in soles from a p.m. till 3 a.m., these pains recur for 4 successive d. at same time. After 56 h,, drawing shooting on r. side near sternum, betwixt »nd and

?,rd ribs. After 60 h., drawing pain in the upper posterior r. side of ribs spreads forward and causes shooting in mamma of same side. Tearing in legs from ankles up to knees, causing tension in calf. After 7a h., on rising, m., mucus mixed with blood is discharged from vagina. A scrapy, rough feeling under sternum compeli her 10 cough, and after several coughs she expectorated some grey, tasteless mucus, whereupon the cough ceased. After *ome d., when combing hair the scalp is very painful, especially when she combs over temples, with falling out of hair. Violent, constant, and very painful stitches in r. side of chest, lasting several d., and much aggravated by in> and expiration. On waking, m , she telt »acral pains, worse after rising, extending forwards to abdomen, and these cause a pressing like labour pains, they go down into legs, cause anxiety and trembling through whole body, with internal rigor (like irregular labour pains), intermingled with shootings in external genitals, better when lying, wor^e when sitting and tvalklng. During first days she never felt as if she had ^lept enough in in., all her limbs teel paralysed. After a d., she has always much heat and watering of eyes. She wakes in m. with desire for coitus. Periodical drawing in mammic, going from outer side to nipple. Just above knees and for 3 inches up tensive pain in muscles, the parts are painful when pressed on by the hand, as though the flesh were torn, nut felt when at rest, r. worst. Afler J d., drawing pains in head from r. frontal sinus to middle of r. jaw, lasting several h,, beginning in m., ceasing at noon, again becoming bad at 1 p.m., and lasting till e. On r. side of sinciput violent stabs as with an awl, so that she does not know what she is doing, her thinking power is completely gone, she goes with this pain to bed, soon falls asleep, and dreams all n. of indifferent things j in m. all

f>ain is gone; it commences in aftenioon. After the pains in arms and legs have asted 60 h. they cease all at once, but immediately afterwards she has great distension of abdomen, as though she was pregnant, with exhaustion, nevertheless the is cheerful j she went to f>ed at n, with the distension, and in the ra. wa* quite well, A «ig7ag shooting round navel, lightning-like stitches dart sometimes upwards, sometimes downwanls, sometimes across, then a rapid shoot goes to 1. mamma, where it ends, lasting ^ h. In I. iliac region, opposite crista ilii, persistent shooting, which darts down into 1. thigh. At n. pressure and forcing on neck of bladder, such as she usually has before confinement, causing a feeling all through her as though she should be confined; this makes her rise 3 times to urinate; each time much hot, light-coloured urine is passed. After the Icucorrhoea has lasted 14 h. it ceases, and she feels exhausted. At 4 p.m. she bad stitches in r, shoulder, ^ h. later she had

several stitches in I. side of cheM, and at 6 p.m. fthe had a very icveK dcmwiag p«ia in r. foot. For 3 n. never getn to sleep before 1 or a a.ra.,lhen she sleeps with tmuf dreams^ and on waking at 7 a.m. both ann» were asleep up to elbows. After 4. dl* urine hot and ha« a disgusting smell, like boiled juniper wood. Jiwt above ike heart violent stitches in chest, which prevent her breathing ftecif , the | relieved by pressure with the hand, lastt 1 h. afternoon. Drawiag ahootiag short ribs when moving and when at re»t, e. Labour-likc sacnl paioi urging to stool, with distension of abdomen. Burning dravnng i beginning round ankles and going through lioles and toes, the punt mre soles, from a.m.till p.m. Soles ofTeet as if gathering. After 5d., dnvrinf in lower part> of 1. ear, spreading all over auricle. From 4 a.m. till nooa mm every j| h., and half a pint is paused each time. After sacral pains utd htMt of ftcc has white discharge from genitals as profuse as meiues. C<Mitnciivc pun like ciiaip in r. calf down to ankles. Alter 6 d., drowsy, much yawning, with putrid taKeaid little appetite. Bad sleep, ios>es about in bed all n., changes from side to udc« and can asikign do reason for her sleeplrssneM, and on rising m. her whole hodT WM wwuf^ on the lightest corporeal exertion warm sweat breaks out all over boajr, sl^ nvK frequently sit down to rest herself, when she stands up she collapaea, laatins is h. After 7 d., the skin of crown and sinciput is painful when combed and when timrhrd with fingers, as if ulcerated ; when the skin is not touched the pain i* dnHriM^wont on crown, lasting 14 h. After 10 d., the 3rd d. of menses, at 5 ajn. a prnffuv and crackling in abdomen, like dull shots, then very urgent call to stools with r^mlffT diarrhcea ; during d. 7 more diarrhceic stooK, without pain. (Arcitiv^ xvi, a, 1S7.)

II. Poisonings, — I. a. On Aug. aqth, 1853, being cmlled to a young woman, xt. 24, 1 found her insensible, with a pale lace tyl frothing at the mouth ; the pupils widely dilated, pulse regular, luD, 80 per m. ^ every few m. violent retching, only saliva being brought up. The stomach had been previously emptied by vominng. She had apparently severe paroxysms of pain on the r. side of her lace, co which she violently applied her hand, then again became praatrate. Her breath smelt strongly of creasote. A large molar tooth on r. aide, lower jaw, had a large cavity in it. I removed the tooth, and ahc scarcely seemed to feel the operation ; after administering a mixture of sesquicarbonate of soda and finding her improving, I left her. In tht m. she was better, but pale and weak, the pupils were still much dilated and the vision imperfect ; this lasted several d.

i>. The patient's own account is as follows : — ^^ Whilst putting a piece of lint saturated with creasote into my tooth, I accidCTttur swallowed it. In less than ^ h. I felt myself * going very low.* ny eyesight went from me, giddiness came on, and everything ]ooke«l daiK blue, even the candles, my husband and everything. I relt a dreadfal burning at the chest, and wanted water to quench it. I vomited and brought up the piece of lint and some food. I had great pain in the front of my head, and felt numbed all over. The pain at the cheat. continued 3 or 4 d. I did not know that my tooth had been uken out.^ (J. D. Jeffrey, Jssoc. Med. Joum,^ 1853, p. 929.)

1. While experimenting with creasote on patients suflferiiig ftoe^ phthisis, 5cc., I found that if the first dose exceeded 2 or 3 dr nausea, vomiting, vertigo, headache and heat of head were genei the consequence. One patient who began with the small dose gradi increased to 40 dr. ; any addition to this dose caused extreme giddinctrib insensibility, and vomiting, followed by headache for several d. (£t,LlO|w 50N3 Med.-Chir. Trans, xix, 217.)

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1. A child, act. 2, swallowed from 20 to 30 drops of creasote. It soon lost consciousnesSi was unable to swallow, and its breathing was much obstructed and stertorous, it vomited, and passed urine of a brown colour, and frothed at the mouth. Evidently in great agony> constantly crying our, finally convulsions ensued, and death in 17 h. At the autopsy 51 h. after death, the body gave out a strong odour of creasote; the lips were discoloured, dry, and parchment-like ; the mucous membrane of the tongue, palate, and oesophagus was of a dirty white colour. The brain and the lungs were engorged with blood, and the ventricles of the heart full of clots, {£. Labbee, Diet. Encycloped. dts Sciences Mid.y ire Serie, xxiii, 103.)

2. Labbee summarises its action as follows : — From a small dose there is noticed onlv a stimulant effect on the digestive tract. From a large dose there will first arise gastro-enteritis, with its accompanying pain, vomiting, diarrhoea, &c. ; then will follow vertigo, muscular feebleness, and circulatory and respiratory difficulties, due to absorption of the poison rather than to sympathy with the gastric irritation. Next there ensue effects due apparently to the elimination of the drug, viz. bronchial irritation, diuresis, dysuria, and even strangury, with black colour of urine. After a massive dose, in addition to the above, serious disturbances of the neuro-muscular apparatus arise, such as muscular weakness, profound disturbance of the sensorium and mind, general trembling, spasms, convulsions and coma. The circulation and respiration are profoundly affected, the heart's action being slowed, dyspnoea and sufl^bcation coming on, terminating in asphyxia from excessive bronchial secretion, and arrest of the heart's action. {Ibid.)

3. Mrs. M. D — , xt. 67, took by mistake 2 drachms of creasote in a draught at bedtime. She complained of feeling " all on fire " after taking it. She lingered in great torment from Monday night until the following Wednesday, at 4. a.m. (Times (London), June 17th, 1839.)

4. a. Strl'mpf speaks of a woman of 60 who took ' a considerable qnantity ' of Kr. by mistake. She was immediately attacked by severe colicky pains, and within 3 h. had upwards of 40 very painful and bloody stools. She recovered under the use of oil, milk, and opium.

b. When large doses have been continued for some time, they are apt to occasion dulness, giddiness, fainting, and some excitement of the circulation, with difficulty of breathing, nausea or retching, muscular lassitude, yawning, and constipation. I'he unne is generally augmented in quantity. Sometimes it occasions difficult micturition, and even strangury. The vapour, when inhaled, is said to occasion stupor. Corneliani relates the case of a woman who was attacked with faintness, trembling, efforts at vomiting, palpitation, &c., in consequence of the continued application of Kr. water to a large ulcer of the leg, (S'riLLfe, op. cit.)

1. Dr. Teste was consulted, in July, 1845, about an infant of 6 months, which was cutting its teeth badly. Kreosote 6 was given with great effect for a weekj and a phial of the tincture was left in the parents' hands to use in case of need. Two months later, the child was brought to him in extreme debility ; pulse small and frequent; countenance sadly changed^ eyes red and projecting; breath foetid 2.% vcv

mercurial stomatitis ; entire anorexia, and vomiting ; and acftnty i diarrhoea. The skin was covered with an eruption, prurigo-Hke oa dK forehead, pustular elsewhere ; and the chest, hypogastrium, and upper thighs with round red spots, on some of which phlyctenule appeared. There were also several ulcers with greyish base on gums and at oonmissures of lips, and a notable enlargement of the parotid and submaxillary glands. Inquiry as to possible syphilitic inheritanGc yiddrrf decidedly negative results ; but it came out that, a week previoualjTt ^ child (though pretty well) seemed a little troubled with his teeth, and had been given the kreosote 6 times ad., since which he had &fallen into the condition above described. The medicine was immediately rttrmied, and without further treatment the child speedily recovered its heudk {Journ. de la Soc. GalL^ i, 75.)

III. Experiments on animals, — i. MiGNET gave dailjr to a doc 1 mos. old 8 dr. of diluted Kr. Its depressing emcta were visible in the slow and painful gait of the animal, and the occurrence of Iraqi nausea, with tremulousness and emaciation. Cormack found that

given to dogs in doses of 30 dr. it produced salivation, vertigoi,

twitching, and insensibility. The same dose, administered to a nbbiC| occasioned violent convulsions and speedy death. In Mignct*t espcriments, a dose of ^ij, administered to a young doe, gave rise to etgns of distress, a fixed look, vertigo, dulness, and indifference. Tile 1 tion was laboured, whining, and irregular; a secretba of appeared to obstruct the air-tubes and hung from the mouth ; and violent retching ensued. At the expiration of 2 h. the became extremely laborious and interrupted by long intervals, the 111 were tremulous and jerking, and death speedily ensued. The lesion discovered was universal vascular injection of the gaitR^ini mucous membrane. The lungs were gorged with blood, and j heart and great vessels this fluid was more firmly coagulated than {5/i7//.)