Volume IV — Main text

THUJA. Thuja tcciJtnlalii, Willd. American arbor vitat. Nat. Ord„ Camferm.

Provings, — i. Hahnemann, Rtine 4rzneimitttlUhre^ vol. v of original, vol. ii of translation. Contains 334 symptoms from self, and 300 from 10 fellow-observers.
a. BoHM, Nov. 1 2th, 1844, took 5 gr. of ist trit. of dried twigs an h. before breakfast (bread and milk) ; in forenoon he experienced slight vertigo and dull pain at root of nose, with feeling of warmth as if a cold would set in ; in e. several times fleeting stitches in heel and in ball of the r. foot, a sensation which he had never before experienced, 13th. — No medicine. 14th. — In m. took 10 gr. In forenoon an increased feeling of warmth over forehead and pressing in f, temple from without inward ; bleeding at nose in e. 15th. — In m. took TO gr. Drowsiness p.m. and e. ; restless sleep at night, and firequent urination. i6th and 17th, — Took no medicine. l8th. — In m. took again 10 gr. Aching in forehead, with obstruction of nose, from which a quantity of blood was blown in e. ; painful stitches in glans. 19th. — No medicine. 20th. — Took togr. in m. Great flow of saliva into the mouth, frequent sneezing, bleeding at nose, and remarkable drowsiness after dinner. 24th. — ^Took again 10 gr, in m. Untuur* dryness in both nasal cavities ; frequent urination, with urging at first, though there was always more water to come away, afterwards without urging ; fleeting stitches in heel and big toe of I. foot. Took no medicine for seven days. Dec. ist. — 20 gr. Dryness of palate ; slight swelling of tonsils, painful, and inducing frequent deglutition ; small white vesicles on tongue, resembling miliary rash. 4th. — Took another 20 gr. Above-mentioned vesicles on tongue^ which had

•Tmost vanished, reappeared, with burning, especially after eating warm food. This was acconipanied with painful compression in region of both malleoli of 1. foot, and slight burning during urination, urine being redder than usual. 8th. — Another 20 gr. They produced frequent eructations, as of rancid grease ; desire to urinate ; great drowsiness in e. 1 2th. — Another 20 gr. in m. They occasioned rancid eructations, violent bleeding at nose almost every time he blew it, and frequent urination, with burning in fossa naviculars.

b. After an interval of more than 2^ months B. instituted a second proving with the tincture. He diluted lo dr. with 6 oz. of distilled water, of which he took two table-spoonfuls on m. of 3rd March, 1845, before breakfast. After 2 h. he experienced frequent eructations j frequent urging to urinate in daytime. Next d. obstruction of nose, which began to bleed as soon as he attempted to expel air through it. 5th. — In m., B. took four table-spoonfuls of the above-mentioned dilution. Headache in forehead with warmth, frequent urination with urging, slight burning under sternum, painful pressure at root of nose. These symptoms disappeared gradually within 3 d. joth. — Eight spoonfuls. Continued rancid eructations ; oppression of chest ; frequent hawking and hacking ; continued burning along whole length of sternum ; frequent urination followed by long-continued urging. 15th. — B. took, as a final experiment, 10 dr. of the undiluted tincture on sugar. The effects were rancid eructations (for 8 h.) ; fluent coryza, disturbing night's rest ; weight on chest ; painful stitches in big toe of I. foot; frequent urination with urging. All these symptoms increased on d. following, subsequently decreased, and disappeared entirely in a few d. (Mayrhofer's provings, (Est. Zeitschr., ii, 309.) 3. Frohlich instituted six separate provings with Thuja. a. 1S44, Dec. 20th. — F. began by chewing a few fresh twigs, and swallowing the juice. He experienced no change in his feelings. 2ist. — In m. he repeated the experiment, and experienced, p.m., protrusion of hzmorrhoidal vessels, with sticking in them when walking; in e., 10 h. after swallowing juice, he felt tearing in 1. knee-joint, extending to middle of calf, commencing while sitting and lasting only a short while. 22nd. — In m. experiment was made a third time. Soon after he felt continuous digging and burning pain in two upper hollow molars of r. side ; in e., 10 h. after swallowing juice, he experienced short but frequently returning paroxysms of lancinating pain from I. acetabulum down to calf, deep in bone (while walking in the street). The toothache was removed by a dose of mere. sol. 3. No chewing on 23rd, lest the toothache should occur again. It returned, nevertheless, whenever he entered a warm room from the street and remained there a little while. He tried nitrate of silver 6, with but temporary relief; and the troublesome toothache, for which cold water wa» the only palliative when the pain was very violent, disappeared gradually in some d.

^. The symptoms of the former proving having entirely ceased for several d., on 2nd Jan. F. took 3 dr. of 3rd dil. in a table-spoonful of water before breakfast. No result. 5th. — In m., 6 dr. of same. A painful stitch through middle of 1. eye, commencing in centre of brain ;

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a few stitches in external tuberosity of I. thigh when walking; the above-mentioned toothache again made its appearance, but only under similar circumstances. I2th. — -12 dr. After walking in open air for \ h., he entered a warm room, when above-described toothache again made its appearance, but soon abated, and disappeared on using cold water. This symptom returned as often as F. entered a closed apartment, even though not heated, and remained in it for a while. The toothache was immediately diminished by inhaling the air at an open window for a few moments. On same day following symptoms were observed : Drawing tension in nape of neck (more on I. side), recurring several times ; feeling of weakness in chest ; frequent emission of flatulence which had not much smell ; drawing, and fleeting deep stitches (resembling slight electric shocks) in various parts of the body.

No medicine was taken from 8th to 19th-, the toothache recurred during all this time under the circumstances indicated above, although several remedies, such as mere, sol., camph.,sabina and nux were taken to remove it.

c. Jan. 22nd. — After the toothache had entirely subsided, F. took 20 dr. of tinct. in a glass of water. That same forenoon the toothache returned torn, after having entered a room without fire ; after dinner he experienced a piercing stitch in 1, hypochondrium, and a continuing squeezing sticking pain in concha of I. ear. 23rd. — In m. 30 dr. .'Vt noon he was unable to distinguish by the taste what sort of soup he was eating (room was dark). Nor was he able to discern the vegetables by the taste, and black coffee tasted like warm water, without aroma. 24th. — 40 dr. : stitches in region of liver when sitting. 25th. — The same dose produced slight colicky pain in small intestines and a few stitches in r. thumb. 26th. — Another 40 dr. : painful stitches in inner side of 1. knee-joint when standing. 27th. — 60 dr. In forenoon he experienced a few deep stitches in I. hypochondrium. 28th. — 80 dr. In forenoon pinching pain in stomach, and feeling of fulness and of being bruised in chest under sternum, which last symptom he had observed for several d. past. No Thuja was taken from 29th of Jan. to 3rd of Feb. During this period the following symptoms were observed : Single deep stitches in hypochondria ; gnawing-stinging pain in stomach (coming on in bed and going off after rising) ; drawingsticking pain in head oft. femur; dulness of senses of taste and smell. Feb. 3rd, — F. took 100 dr. of tinct, in a tumblerful of water before breakfast. An h. after, he experienced a single stitch through lower portion of lungs from behind forward. This was accompanied by bruised sensation in the chest, with dulness of the head, sad mood and discouragement, alike in the open air and in the room. Afterwards the well-known toothache made its appearance again in the usual paroxysms, and in e,, while sitting in a crowded theatre, he experienced a drawing-sticking pain in r. forearm, extending from elbow to wrist' ■ joint. 4th. — Painful stitch through occiput from above downward." 5th. — The troublesome toothache came on again as often as F, entered a closed apartment from the open air, and continued until the 23rd. During that period F. had several characteristic sym* ptoms of Thuja, especially in the limbs, but which were not not

^^Ewn because he had taken several remedies, such as sabina^ rhus and ^Katztreum against the toothache with only transitory relief.

d, April 4th. — Before breakfast F. took 20 dr. of the llth dilution

in 3 oz. of distilled water. While proving the attenuations he avoided

e^erv kind of spirituous beverage^ and partook of the plainest food.

blh.—He felt vertigo with fulness in head, and hands became easily

♦liiFand tired when moving them. 7th. — 12 dr. of the nth potency

produced the following result : In forenoon, while walking in the

itTCCt, he felt a few deep stitches in r. groin ; afterwards he felt

a violent drawing tearing from I. clbow-joint as far as the two middle

fingers; vertigo at home, with vanishing of letters when reading,

and continued digging pain in two hollow upper molars of r. side,

relieved by cold water, but increased by warm soup and tobacco-smoke.

8th.— Feeling debilitated all over as by fatigue, and gloomy, was

compelled to take a little wine, after which all the above symptoms

^^ diuppeared.

^H (. April 22nd. — After all the symptoms of Thuja had ceased and ^^ the carious teeth had become entirely free from pain, F. took 80 dr. of the tinct. before breakfast, after which he swallowed a glass of water. No effects were observed either this or the next d. On 24th and 26ih he took icX) dr. each d. On the latter d. prover experienced considerable dulncss of head and mistiness of sight ; on dorsum of r. foot a small blotch was discovered with a red areola, which rendered walking in boots dificuU. 28th. — Another 100 dr. The blotch is diminishing, and nothing remains of it except a dark red, somewhat elevated spot with slighter areola, still impeding walking. General weariness during d. uifhe had not slept all n. These symptoms are accompanied by duiness of head, sad mood, dulness of taste, indistinct sight, and bad, sunken appearance. Nevertheless, on 30th F. took another 100 dr. In forenoon : dulness of head^ with vanishing of objects when attempting to fix them. In afternoon : painful stiftness of nape of neck when moving head, bruised sensation in chest, dulness of taste and very gloomy mood. The efflorescence on the dorsum of the foot began to »ubside. May 2nd. — Another 100 dr. elicited no new symptoms. No medicine was taken on 3rd and 4th ; during this period F. observed the following symptoms: Dulness and feeling of fulness in head, with ill-humour and drowsiness ; after a siesta of | h., vertigo so that he could scarcely walk without holding on to something ; great sensitiven«ss of skin to cool air. 5th. — F. took the last too dr. Result: 'ticking tearing in tarsal joint in forenoon, while walking. Another little blotch makes its appearance in the still existing red spot on the dorjutn of the r. foot, impeding walking very much. 6th. — In m., in ^d, sticking beating in r. hand extending as far as tips of fingers, and in anterior part of r. foot. Towards noon, pressive headache with PRHure in both eyes, accompanied with gastric uneasiness and reddened urine. F. had to lie down on account of increasing debility, *nd WAS not able to go to sleep for several h. 7th. — He felt a general debility as from fatigue; feeling of fulness in head ; a paralytic burn- '"g tcnsation, which had been felt already for some d. past in all muscles of forearm, and which extended as far as tips of Hngers, was

aggravated headache At 8 p.m. : aching vertigo when walk-

particularly troublesome (coming on when moving arm, going off in rest). In the afternoon and c. : feeling of coldness through back, with debility and stiffness in all the limbs; duJness of head ; sticking pain in 1. patella when going up stairs j great debility in sacrum and lees, and feeling of weakness in chest. 8th. — After having spent a n. full of dreams, F. woke greatly improved ; head continued dull^ and he was attacked with turns of vertigo after talking long ; at noon he felt chilly all over, especially on extremities; he was ill-humoured and restless, and had canine hunger without thirst. A small quantity of wine which he took at an unrelished dinner very much, and smoking increased it to vertigo.* pain, especially in frontal eminences and temples ing ; bruised pain in shoulder-joints and upper arms ; weak feeling in chest with pressure under sternum and difficulty of breathing, especially while going upstairs. 9th. — F. felt better in every respect, and all the symptoms disappeared within a few d., except the wealc feeling in chest and difficulty of breathing in going upstairs, which did not entirely leave him until the end of the month.

f. May 2i3t. — F. swallowed before breakfast a table-spoonful of recently expressed juice, obtained by crushing the twigs of Thuja and pouring upon them a mixture of equal quantities of distilled water and alcohol. Of this nauseous juice F. took one table-spoonful on the Itt and and of June, and two table -spoonfuls on the 3rd. On the lastd. he experienced in forenoon frequent paroxysms of tearing and sticking in both hands, which became so violent in middle of r. ulna while he was writing that he had to give it up. P.m., while driving in a carriage, he experienced very violent tearing in 1. forearm, which wa» especially violent in anterior tuberosity of humerus, that region becoming vzx'^ sensitive to touch. Moreover, prickings in fingers of same hand. These symptoms continued while driving, and did not abate until F. got into a profuse perspiration in e. while in a crowded theatre. Upon moving hand quickly and strongly he felt burning pain in all muscles of forearm. 4th. — F. again took two table-spoonfuls of juice, which did not produce any new symptoms. The tearing pain in anterior tuberosity of 1. humerus continued, was increased by motion, and was heightened to a burning pain by contact, especially after the painful spot on the arm had been knocked against something, though only slightly. The red spot on dorsum of foot impeded his walking very much. Under sternum he experienced oppression, with bruised sensation in chest. These symptoms were accompanied by frequent hawking of mucus, dulness of taste with great appetite, and swelling of hiemorrhoidat veins. 5th. — The following symptoms were observed : Sensitiveness of anterior tuberosity of 1. upper arm, especially when touched ; in afternoon, feeling of fulness in head with drawing pain in nape; feeling of weakness in chest; painful stiffness in I. forearm extending as far as fingers, and impeding motion ; pressing sensation in the turgid hemorrhoidal veins ; sticking burning pain in external tuberosity of 1. tibia (coming on when sitting and increased by pressure).

• As the use of wine was beneficial previouiily, thisaggravalion seems to be rather atrnbutable to the effecti of a meal eaten with canine appetite. — Mayrkoftr.

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Al] these symptoms disappeared gradually on the following days except the great sensitiveness in the tuberosity of the humerus, which seemed to become more and more circumscribed every day, but which only entirely disappeared in the course of a week. The last to yield was the hemorrhoidal congestion, to remedy which he used several bottles of a mineral water. {Ibid.)

a. Caroline P — , act. 45, took 10 pellets, moistened with 3rd dil., Nov. 1 2th, 1 844, before breakfast. Two h. after, she experienced drawing froTa I. axilla as far as elbow-joini ; afterwards drawing along vertebral coiumn and in calves, with feeling of weakness in legs. 13th. — Prover again took 10 pellets, which elicited following symptoms : Drawing from r. wrist as far as tips of fingers, and from r. calf as far as malleoli, with sensation as if foot were lame ; afterwards drawing from r. elbow as far as wrist ; then transient paralytic feeling in both thighs as far as knees. 14th. — After another 10 pellets she experienced weakness in knees and decrease of appetite. No medicine was taken on 15th, i6th, and 17th; during first two d. above symptoms were yet slightly felt. From i8th to 23rd, Caroline took 10 pellets every d., and observed following symptoms : Drawing sticking in r. upper arm as far as elbow, and in r. thigh as far as knee ; sticking in r. forearm as far as finger-joints ; drawing in both scapulx in direction of nape of neck, in both legs from knees to malleoli, and at same time in both forearms from elbows to wrist. These symptoms generally appeared 3 or 4 h. after taking drug, and lasted from 10 to 16 h. Prover discontinued medicine until 26th Nov., when she took another 10 pellets. On that d. she experienced sticking in 1. thigh as far as knee, single stitches in 1. tarsal joint, and in e. drawing in both thighs. 27th, 28th. — She again took 10 pellets each time, after which she experienced tearing in I. upper arm, afterwards in 1. leg ; sticking in 1. wrist extending as far as tip of index finger; drawing in 1. calf, afterwards in r. forearm from elbow as far as wrist. Dec. 5th, 6th, and loth. — She took 10 pellets each time without experiencing any new symptoms. Same drawing and sticking was experienced in various parts of limbs. On inner surface of 1. forearm a red, round, itching spot was observed, with white vesicles raised upon it, which burst, poured out clear lymph, and left a yellowish crust behind.

b. Dec. I2th. — Before breakfast, F. gave prover 10 pellets of 202nd dil., without her knowing that preparation was different from what she had previously taken. Results ; drawing in both hands and feet, afterwards only in forearms as far as wrists, and sticking in both sides of chest. 13th. — She took another 10 pellets, with same result. 19th, 20ch. — She took usual number of pellets, and observed, besides symptoms mentioned above, drawing in both hips from without inward, d from above downward toward genital parts. After an interval of 2 d. prover took to pellets of same on 2nd, 3rd, 4th, 6th, 7th, and th Jan., 1845. After every dose she experienced tearing, drawing or sticking sensations, accompanied with repeated attacks of vertigo, and feeling of stiffness in legs and back, as far as nape of neck. Prover having taken cold, in consequence of which she was attacked with toothache and swelling of the cheek, the experiments were concluded.

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F, mentions that prover had frequently asserted with great positive* ncss that she had experienced with more intensity all her former symptoms ever since 1 2th Dec, when she took the 1st dose of Thuja 202. Wc ought to state that prover observed a very plain diet during whole period of proving. {Ibid,)

William Huber, of Lint, instituted three provings upon himself with Thuja.

a. 3J of 3rd attenuation* which H — took on ilth September^ 1844, ac 8 o'clock a.m., produced no effect. He took a similar dose on 13th at 5 o'clock a.m. ; after i^ h,, while lying in bed, he experienced a momentary starting in epigastric region, in direction of the J. hypochondrium, as of something alive. Next d. he took a 3rd dose of same dil., but observed no further symptoms. Sept. 15th. — At 6 a.m. H. took5J of 5th dil. One h. after dinner he experienced a fine transitory stitch in posterior surface of the 1. ulna near elbow; soon after a sudden starting bounding sensation in r. iliac region, as though from something alive; in ^ h. afterwards he experienced painful drawing in outer surface of 1. upper arm near olecranon, recurring several times at short intervals. At 8 p.m. H. experienced sensation on glans near frenulum praeputii as if spot had been excoriated, although no change was visible. 16th. — Took a similar dose, after which same feeling of soreness on glans, only when touching it ; at 4 p.m. a few fine stitches in fossa navicularis of urethra; an h. afterwards, during siesta, he experienced a second time a sudden bounding up in abdomen, accompanied with starting of whole upper part of body, as if from fright. 17th, — After a similar dose drawing intermittent pain in I. side of forehead, and at same time symptoms of colic, accompanied by emission of flatulence^ 1 8th. — 5J of 4th dil. a.m. and p.m. ; this caused in n. profuse secretion of insipid saliva, and painful tension in r. side of nape and in sacrum. 19th. — Dose was repeated, causing slight tension in 1. side of nape, and a pretty severe sticking crosswise where radius and carpus unite, from without inwards (in rest). 20th. — In m. H — repeated dose. After lapse of an h. he felt as if stomach were deranged, with pressure over scrobiculus, which impeded respiration. At 9 he experienced pain in 1. side of forehead when writing, which continued the whole a.m. ; upon being waked from the siesta H. became giddy, and had great trouble in collecting his thoughts. 2ist, 22nd, and 23rd. — H. took 3J of 3rd dil. at 7 a.m. On ist d., towards 9 a.m., he experienced aching in epigastrium, towards r. hypochondrium, for \ h. (more in rest than when walking). On m. of 2nd d. duEness of head, and at 10 painful drawing in 1. thumb, lasting only short while, but returning frequently. On 3rd d. sudden sensation of giddiness was experienced at 11 a.m. while writing. He felt as if a current of air was ascending from occiput and penetrating towards forepart of head, causing vertigo and loss of thought. 24th, 25th, and 26th. — H. took gj of 2nd dil. in m. Result : after 1st dose he experienced a momentary tearing in dorsum of I. hand, at noon, while writing ; after 2nd dose several stitches were experienced periodically inl. side of chest, apparently deep in peccoralis

All th«« dils. were on the decimal yc»\t.

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major muscle. 3rd dose was without result. 5J of ist dil., taken on 27ih, 28th, and 29th of same month, was likewise without result.

b. Second proving was made with the tinct. Five dr. on m. of 30th Sept. produced no effect. Oct, 1st. — 8 dr. In e. while chewing a piece of bread, H. experienced intense sticking pain between 1. ear and zygomatic arch, as if jawbone had become suddenly dislocated, extorting a scream. This pain was experienced every time he attempted to chew, continued whole e., and was still felt next m. 2nd. — In m. 10 dr. As soon as he awoke he felt an extremely disagreeable, painful sensation in nape of neck, close to occiput, as if he had been lying on a hard couch. In course of d. this pain spread over whole of r. side of back, as if muscles in that part of body were sprained, and was felt especially when bending head forward and raising r. arm.* In e. pain moved more into region of r. shoulder and neck i upon chewing bread before-mentioned pain in muscles of mastication was again experienced. 3rd. — In m. 16 dr. After dinner voluptuous itching in forepart of urethra, while penis was relaxed. The pain in r. posterior cervical and dorsal muscles continued whole d., accompanied with whizzing and buzzing in r. ear. On bending head forward he experienced sensation as if muscles were too short, and as if pain was caused by tension of the muscles. Had quiet n. after taking 40 dr. in e. 4th. — 26 dr. Shortly after taking drug pain in nape of neck, shoulder and back was increased to such an extent that raising of r. arm and carrying hand behind head caused most exquisite pain. He was unable to bend head forward or turn it } in order to accomplish this he had to move whole upper part of body. Pain was a sort of tumultuous digging, as if muscles had been crushed, and as if a gathering were taking place in subcutaneous and intermuscular areolar tissue. On same d. he had two papescent fetid stools, and in e., after eating a warm soup, a vaporous perspiration broke out all over body, continuing for { h., and followed by diminution of pain in nape of neck -, on following d., however, H — was not yet able to tie his cravat behind, or to hang the chain of his watch around his neck. On looking at r. shoulder in glass, it was found to be somewhat more elevated than ].,and swollen ^ taste in mouth was insipid, with sensation as if stomach were disordered. 5th. — 30 dr. At 8 a.m. he had a large evacuation, at first hard, afterwards papescent, clayey and fetid. The disagreeable sensation in stomach continued all d. At 7.30 p.m. painful tension in bottom of 1. orbit for several m. 8th. — 60 dr. After lapse of \ h. several painful stitches in forepart of urethra, penis being relaxed ; afterwards transitory cramp-pain in r. ear, and several times fine prickings in various parts of skin as if with needles, which sometimes changed to burning ^ also painful burning sensation between prepuce and glans, continuing from 6 to 7 seconds, and returning several times at short intervals, without any change in parts perceptible to eye. At 10 a.m. he experienced painful drawing in 1. frontal eminence (while walking in open air), and itching of anus, which induced scratching. At 4.45 p.m., while sitting, sensation in urethra

• Dr. Huber observes that he had never been affected with rheumatism of the nape of the neck. — Mayrhoftr.

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as if a drop of viscid fluid were pressing forward. At 5 drawing pains were experienced directly below r. internal malleolus (lor a few seconds). On m. of following d. orifice of urethra was closed with slimy fluid, consisting of a serous liquid and a lump of mucus, which could be drawn into threads by fingers. After removing this liquid slight burning was experienced on urinating, gth. — 7 a.m. H. took 80 dr. After lapse of 15 m. 1. eye began to water, r. one remaining dry i confusion of head whole a.m. ; whizzing in 1. ear ; painful pressure in superior and posterior angle of 1. parietal bone, as if a small convex button were pressed against that part (going off rapidly when touching it). At 10 a.m. painful drawing, extending from bend of r. thigh to internal surface of thigh for a (ew seconds (in rest). After dinner pain in r. parietal bone, as if a pointed nail had been driven in ; violent vertigo when sitting and closing eyes, as if sofa upon which he was sitting were balancing to and fro (going off immediately when opening eyes). At 4.30, during siesta, he experienced a momentary darting pain in gums of r. upper jaw. (The affection of bacic and nape of neck had now by degrees wholly disappeared.) loth. — lOO dr. After lapse of 2 h. transitory jerking formication in fossa navicularis of urethra, accompanied with voluptuous feeling without erection ; dulness of head whole a.m., with paroxysms of drawing pain in middle of forehead, which was especially violent in 1. frontal eminence, and thence extended to posterior portion of 1. eyeball, and at times as far as occiput, and at 3 p.m. passed into constant digging pain. This headache was as violent in open air as in room, and lasted until 10 at o. Occasional sensation in r. epigastric region as of something alive moving there ; frequently painful jerking in penis, accompanied by sensation as if viscid liquid were exuding from urethra, which, however, was not the case. He fell asleep after midnight ; on following m., when waking at 6.30, dull drawing pain was experienced in r. frontal eminence, extending as far as r. orbit and r. nasal bone, setting in in paroxysms and ending at 8. R. eye was dry, and in margin of lower lid there was a burning spot as if a stye were about to form. He felt, besides, whizzing in I. ear, and once a fleeting stitch in 1. testicle, nth. — At 8 a.m. H — took 120 dr. After an h., a jerking, voluptuous formication was experienced in forepart of urethra (while walking in street)^ penis being relaxed. At 10 a.m. painful drawing in r. side of forehead, ceasing and returning several times, At 12.30 painful drawing in 1, posterior cervical rcgionj close to occiput, alternating with similar pain in r. frontal eminence. Afterwards creaking in both ears when swallowing, resembling turning of a wooden screw, accompanied with sticking and feeling of dryness in r. outer canthus, as if a grain of sand had got into it. At 2 p.m. he experienced frequent attacks of painless twitching in back towards 1. loin, like a muscular twitch. On waking next m. scrotum, perinxum, and inner surfaces of thighs were dripping with sweat,* and, a few minutes after,

• Dr. H — ob«:rvc« that this swca^ of the genital organs reminded him invoIun> tarily of the assertion of hi* teacher, Von HiMcnbiandt ; "Jmatit andjittiwla lee* tUa, ut fungi."

roxystns of drawing pain were experienced in bottom of r. orbit,

itinuing ^ h. The same phenomena continually recurring, H — concluded provings h tinct. by taking 140 dr. of it at 8 a.m. on 12th. After ^ h, ing of dryness in both eyes, with painful sticking and creaking in li cars, as when a wooden screw is turned, especially during empty lutition. In ^ h. after, a short painful drawing in 1. side of ■put. Two h. after, clawing aching pain in 1. frontal eminence becoming fixed in a small place (for a few m.\ accompanied with rumbling in bowels. After 9^ h. colicky pain in r. iliac region for a kw m., while walking in room ; shortly after a (ew shooting stitches in urethra, and drawing headache in r. forehead. These symptoms , lasted with more or less intensity during subsequent days, and a few more were fielt on 2ist^ such as feeling of soreness about hard palate, I as if burnt and covered with vesicles ; periodical pinching in middle of I 1. calf as if convex button were pressed upon part, the same sensation I being experienced in mastoid process of r. side 5 shooting stitches from neck of bladder towards urethra. These phenomena became gradually weaker, though some of them were yet experienced on 30th Nov., ^Bore than six weeks after prover had taken his last dose of Thuja. ^B e. After all symptoms produced by increasing doses of tinct. had ^entirely disappeared, H — experimented with the 60th dil. (i : 99), not, PBowever, without a pre-formed conviction that the experiment would ' be wholly without result, and was therefore much astonished at again experiencing not only many of the old symptoms, but also others which he had never before felt. Jan. 16th, 1845, H — took 10 dr. of 6otb dil. at 1 1 a.m. After ^ h. a slight pressure in pit of stomach and in chest, impeding respiration. Sticking tearing pain in muscular parts of r. side of nape of ncckj in e., extending as far as scapula (continuing only a short while, but returning several times with considerable violence). Soon after, a similar pain in 1. forearm, where ulna joins carpus. On m. of d. following, H — experienced sensation in abdomen as if a child's knee were pushing against anterior abdominal walls from within. 17th and l8th. — 10 dr. produced no symptoms. 19th. — Same dose occasioned following symptoms : — voluptuous itching in forepart of urethra, penis being relaxed, accompanied with sensation as if a few drops would flow out ; jerking in 1. hypochondrium, towards epigastrium ; transitory pain in 1. frontal eminence as if nail were driven in. This pain disappeared at once on touching part, returning, however, immediately at superior posterior angle of I. parietal bone, as if a convex button were pressed against part. 20th. — 12 dr. at 10 a.tn. i frequent lachrymation of 1. eye (when walking in open air) ; digging headache in 1. frontal eminence at 5 a.m., returning several times at short intervals, and alternating with sensation as if a convex button were pressed upon parts near vertex. This same sensation, which ceased immediately upon parts being touched, and returning again as soon as contact ceased, was experienced several times in r. mastoid process, in 1. parietal bone, and under r. clavicle. In e. he perceived a painful little tubercle in middle of I. eyebrow, and, after he had gone to bed, a digging-tearing pain was experienced in muscles of

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r. side of nape of neck, extending momentarily as far as r. scapuli, uni being relieved by touching, accompanied by roaring in 1. ear and creaking when swallowing saliva. On following m.^ after waking, pressure and tension in 1. and afterwards also in r. orbit. 2 1st. — Took 15 dr. P.m., the well-known pressure as with a convex button over 1. parietal bone. E., H — suddenly experienced a momentary pressure, as of a nail which had been driven in, in 1. frontal eminence (while walking in street), and after returning home and entering the room, a luminous disc size of a pea hovered before his eyes j it shone like a fire-fly {Lampyris noctiluca). 22nd. — No medicine was taken. In e. he experienced a transitory pain in I. frontal eminence as of a nail which had been driven in. 23rd. — H — concluded his provings with 17 dr. of 60th dil. At 10 a.m. drawing-sticking pain in 1. temporal muscle, increased by mastication and diminished by contact. This pain continued for 2 h., and in open air as well as in room. At same time H— experienced a beating-tearing, with sensation of heat, in r. frontal eminence, and a pinching pressure in dorsum of 1. foot, occurring frequently during d. 24th. — On waking, drawing pain in 1. frontal eminence (this pam had made its appearance already in e. after lying down), and profuse sweat about genital organs. A.m., while walking in open air, headache in forehead over 1. eyebrow, extending as far as r. side of forehead. In e. continuous drawing and tension below mastoid process of r. side, accompanied with occasional drawing in I. frontal eminence towards temple, and with roaring in 1. ear. 25chand 26th. — No symptoms observed ; but on 27th, a few moments after waking, H — had a complete hemicrania* in I. side of forehead. It was a violent drawing pain, commencing directly over 1. upper eyelid, extending perpendicularly upward through middle of 1. eyebrow, and dividing in I. frontal eminence into a number of threads and rays which penetrated deep iivto brain. This symptom lasted a few m., and dis* appeared as rapidly as it came, Feb. 13th. — On this date, clear T. symptoms having been constantly present in intermediate period, H — discovered a painless nodule near borders of hair on I. side of nape, disappearing again on following d., except a small rough place. t6th. — A tubercle was observed on inner side of r. thigh 1^ in, from perinscum, which felt like a wart and looked dark red, size of a hemp-seed, tip having a dingy-white appearance, and base being surrounded with a bright red areola of some 3 or 4 lines wide; it was somewhat painful when touching or moving it, and was filled with pus on d. following. A few d. afterwards it changed to brown scab, which came off spontaneously. The most remarkable thing in the provings of Huber is the length of time during which he observed effects. Even as late as 10th March, 46 d. after he had taken any of the drug, he distinctly, although feebly, felt several of the effects of T. The symptoms of head lasted longest and were most frequent, especially sensation as if a nail had been driven iii at angles of parietal bones ; as this sensation ceased an itching-gnawing was experienced in same region, which induced him to scratch. The sensation as of something alive in abdomen, and seeing of a luminous disc shining like a fire-fly, lasted as long. This was sometimes per* • H — had never had any hemicrania before. — Mayrhojtr,

ceived in daytime, but most frequently at twilight in room. Afterwards this luminous circle, which followed movement of eyeball, and Was hovering at various distances now before one, now before both eyes, assumed a more elliptic form, and had a dark violet or blackish nucleus in centre. Sometimes disc was size of millet or hemp seed only, but always luminous on edge. {Ibid,)

W. HuBER, brother of former prover, surgeon at Kleinzell, proved T. on 6 persons ; on himself, on 2 females, one of whom was bis own wife, and on 3 of his children. W, H. instituted 2 provings on his own person.

a. April 19th, 1845, W. H. commenced with the 30th dil., taking every m. before breakfast 100 dr., and descending scale of dils. until he had reached the ist on 18th May, when first proving was concluded. After taking 21st dil., he for first time experienced slight pressive headache over superciliary eminence ; after 20th, violent pressive headache, commencing in post, and inf. angle of 1. parietal bone, and extending as far as r. frontal eminence. The pain only lasted while vcr remained in state of rest ; every movement diminished it, and it turned immediately after movement ceased. This pain became espeially violent after 19th dil. It commenced \ h. after taking medicine, and lasted all d. Even on d. following he was awakened by it at 5 a.m. and was compelled tu rise, after which it ceased ; the head, however, remained stupid and full. This was accompanied on same d. by frequent attacks of boring pain in region of bladder, with painful

I drawing up of testes. From 1st until 12th May, W. H. took from ilie 18th to the 7ih dil. Headache continued with more or less Bolence ^ on last d. it was accompanied with roughness of voice and scraping sensation in throat, which, however, continued only a few h. ■rom 13th to 1 8th May he took from 6th to istdil. Headache gradually Hsappeared. In place of this, H. had almost daily attacks, and sometimes several attacks a d., of boring pain in region of bladder, with painful drawing up of testes, which was accompanied with occasional urging to stool. All these phenomena were but slightly marked ^^during last period of proving, and disappeared in a few d. after medi- ^B|ne was discontinued.

^^ b. June i8th. — W. H. took 10 dr. of tinct. before breakfast, increasing dose every d. by 10 dr. During Jst days above-described headache again made its appearance, but it was less violent, and ceased I entirely after 4th d. On 5th d., an h. after taking drug, he cxpe- ^Bienced sensation in r. side of throat as (hough it were abuui 10 inflame ; BVuring whole of that d. he experienced stinging pains when swallowing, which disappeared again entirely in subsequent n. Nosymptoms made their appearance from 6th to 1 0th d., except nausea on taking drug; this nausea was excited even by mere sight of medicine. July 7th H. took 200 dr., and repeated that dose on gih and 12th of same I month. Every time he took dose he felt nauseated and disposed to ^Bpmit. The above-described headache appeared again immediately PHfter taking ist dose, but it never reached the violence it had while proving attenuationtj although it continued until 15th July. Thegiddiness and obtuseness of head, on the contrary, were more violent. These

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symptoms were accompanied with want of disposicion to do anything, ill-humour and inclination to anger, pain in throat during deglutition, and sour-smelling sweat almost every n. These phenomena continual in greater or less intensity during proving, and even a few d. beyond.

c. H.'s wife made two experiments with Thuja. From the 19th April to i8th of May, Mrs. H. swallowed 100 dr. of the various diU. from 30th to 1st, at the same time and in same order as her husband, without experiencing any other symptoms except slight vertigo and some headache in forehead. The second experiment was likewise instituted simultaneously with that of her husband, from 1 8th to 28th June, with this difference, that, whereas he took progressively increasing doses, she took 10 dr. a d. for 10 d. in succession. The prover was but little affected by those doses. On 5ih d. after com' mencing proving, several wart-shaped excrescences, of size of a poppyseed, made their appearance on both hands, gradually increasing during proving, and amounting in number to 16. At conclusion of proving they varied in size according to the different periods when they had made their appearance. Their shape was that of a truncated cone j their surface was smooth, and they appeared to be seated in epidermis.* A fortnight after concluding proving, the warts ceased to grow. The largest were of size of a small pea, and their formerly smooth surface had become rough and split. The remainder were smooth and of various sizes according to their respective ages. They remained in that condition until about the middle of August, when the larger ones became depressed in centre, and resembled a little pit surrounded by an elevated ridge. This ridge disappeared gradually, together with the wart. The smaller warts disappeared without going through this process. On TOth Sept. 8 warts still remained, and on nth Dec. (more than 5 mos. after proving had been concluded) all the warts had dis* appeared except a small one on 3rd joint of 1. little finger.

d. Three of the children of W. H. likewise proved dils. of Thuja, from 30th down to the ist ; two boys, of 5 and 10, and a girl of 7. No symptoms were discovered in any of the children, except warts of above-described shape on hands, of which elder boy had 6, the younger 5, and the girl 3. On 14th Sept., after results of proving bid been sent in, new warts continued making their appearance in elder boy, and on nth Dec. he still had 22 of different sizes ; while on that day the warts of younger boy had all disappeared but one. No further information has been received in relation to the 3 warts of the girl.

e. Prover is 40 years old, of a stout make, middle size, and safl* guine temperament. Her menses appeared early, she married at age of 20, and has 5 healthy children. Except during periods of pregnancy and lactation, her menses were very profuse for 3 or 4 days; her health was constantly good. Three years ago she was attacked with horny warts, one on tip of I. ring-finger, 2 in palm of 1, and one in palm of r. hand ; they troubled her a good deal in her domestic affairs ; while Washing, either in cold or warm water, they became cracked, and

• Ruber's wife had formerly been troubled with wans, and, when she cotxv nienced the proving, she had one on the dpniiiin of the iett hand, which had bccfl in existence for several years. — MayrAofer.

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[exhibited deep painful rhagades on the surface. Being informed that

»he might possibly get rid of her warts by proving Thuja, she consented

toundertaice it. From 3rd May until 30th June, she took 6 dr. of

ilinct. every d., ajid from 1st to 26th July, 10 dr. a d. The prover

living at a distance, H. could only see her occasionally, and he recorded

blowing observations at those intervals: — May 1 ith.^Prover com-

■^ned of frequent attacks of vertigo and diminished sleep. Her mood

tt2s anxious, and the menses, which appeared on 6th, were inconsider-

ibie and lasted only one d. 19th. — Her complaints were the same.

The vertigo frequently made its appearance when sitting or lying down ;

during d. &he frequently experienced a transitory tremulousness over

whole body. 26th. — The above-mentioned phenomena continued,

especially the anxiety. She thought she could not continue drug,

because she had almost entirely lost her appetite, and suffered con-

ilifltly from a sweetish taste ; even streaks of blood were occasionally

Men in saliva, and warts became still more painful. She consented,

however, to go on with the drug. June 3rd. — The former symptoms

continue. Moreover, wart-shaped excrescences of size of poppy-seed

were discovered on dorsum of either hand, 6 on the 1., 4 on r. in

<ii/time she is frequently attacked with chilliness, feels very weak, and

ha a slight leucorrhceal discharge, which she never had before. The

old, homy warts arc very painful when touched, or while she is at

•oflt, but the new ones are painless. loth. — The chilliness has been

tloiwt constant since the 3rd, the prover has no appetite, is quite unwell,

^t, debilitated as by fatigue, without being able to state what ails

l>er. The warts look as if split up, and exhibit deep, painful rhagades^

especially while washing. To her great dismay, the new, painless

*i:ts became larger every d. The leucorrhora lasted until 8th, when

t^c menses made their appearance, which, however, lasted only a single

iijy and consisted in the discharge of a small clot of black blood of

*iz« of hazel-nut. On 9th, the leucorrhcea reappeared. It is but

*canty, but obliges her to wash herself frequently in daytime. It is

"Und, yellow-green, and leaves spots of a similar appearance on her

Wii. 1 6th. — The leucorrhoea increases. Every d. she feels a pain

•J if bruised, at times in shoulders, at times in thighs. When stepping

*lie feels an ulcerative pain in soles of feet, and they sweat constantly.

The homy warts become more painful every d., and the skin around

'liein becomes slightly reddish. The new warts are painless, almost

ss large as the old, of shape of truncated cones, have a smooth surface,

and appear to be seated in epidermis only. Besides these, traces of

^lewwans are perceived on dorsa of hands and on fingers. a6th. —

Tbe pctin in shoulders and thighs ceased 6 d. ago, the ulcerative pain

insoles of feet continues, the leucorrhcea and the chilliness continue

'ilccwise. The painful old warts are still surrounded with a red areola,

^^d the rudimentary traces above mentioned have been developed into

•Onew warts of size of poppy-seeds. 30;h. — The ulcerative pains in

'olevoffcet have ceased. The other symptoms continue. July 8th.

'"Having taken 10 dr. of tinct. every d., she has felt worse ever since

Otdosc. She complained of being faint, chilly, anxious, and that she

W lost her appetite. This condition continued until 7th, when

menses appeared, after which troubles diminished. Nlcnscs lasted only one day, and consisted in the discharge of 3 clots of black blood, of size of a hazel-nut. Lcucorrhora continued after menses. i8th. — Last 10 dr. had affected prover very much. The frequent chiUincss with debility was now accompanied with difficult breathing, short and hacking cough, and momentary palpitation of heart. These symptoms were especially troublesome in daytime: nights were quiet. The old warts presented same appearance as before : the new ones (ftrst crop) have assumed an irregular shape, and exhibit a rough surface. The mo&t recent warts (2nd crop) had become somewhat larger, and traces are even perceived of a 3rd crop. The leucorrhaea continues, and prover thinks she has become thinner during period of proving. 26th. — All symptoms continue in an increased degree. The difficulty of breath* ing and the feeling of anxiety attending it are especially troublesome. The appetite is almost entirely wanting ; every meal causes pressure at stomach. The debility is worse. The prover looks pale and sickly. Her dresses have become loose. There are 4 sets of warts : the oldest are still surrounded with red areolx ; the next have a rough surface and an irregular shape ; the smaller warts of the 2nd crop have smooth surfaces, and the shape of truncated cones ; and lastly the warts of the 3rd crop, which arc very small, from size of a poppy-seed to that of a millet-seed. As she not unreasonably feared that continuing the experiment would produce further trouble, and increase the number of her warts, she put an end to the proving on 26th July. All symptoms continued with diminished violence until 3rd Aug. Warts remained unchanged, except that last crop seemed to have ceased to grow. On 7th Aug. menses made their appearance; they were somewhat more copious than last time, and lasted a d. and n. On their appearance aJl other symptoms diminished, even the old warts became less painful, and red areolae paler. All recent excrescences remained unchanged 1 8th. — Most symptoms had disappeared ; she had a good appetite, breat. ing had again become easy, and leucorrhcea had ceased. The old wa, had become smaller and less painful, and they ceased to crack duri washing. The 3 subsequent crops continued unchanged. By 3 Aug. health and good looks of prover had entirely returned. The old warts had ceased to be painful, had much diminished in size, were even scarcely raised above skin ; several of the new warts had disappeared without leaving a trace, and remaining ones were much diminished. Sept. 8th. — The old warts had almost entirely disappeared, and rcccn^j warts likewise. The menses, which appeared on 5th Sept., lastd^| 3 d., and flowed as before the proving. By Dec. 1 ith, 138 days aft^^ conclusion of provings, the old horny warts had disappeared without leaving the least trace in the epidermis. Of the recent warts nothin<' was left at that time except a very small trace of one only. {Ibid.)

a. F. LacK-NER, student of medicine, 22 years old, of melancholic choleric temperament and robust constitution, had dysentery when boy, also scarlet fever and measles ; was frequently affected with won and toothache) and had a violent ophthalmia when he was 16, which left a great disposition to congestion to head and eyes, continuing present time. For last 4 years L. has enjoyed excellent health, 18,

t. loth. — He commenced proving Thuja with 6 dr. of tinct., which took in m. They caused eructations, colic towards noon, and diarrhoea, nth. — 8 dr. had same effect. 12th. — 10 dr., after which colic became exceedingly painful ; it diminished gradually after a ^ copious evacuation. In hypogastrium prover experienced a sensation ^B of pressure, especially directly above symphysis pubis. 13th and ^Kth. — L. took 12 and 14 dr., and no medicine on 15th. On all chose ^K> colic was less, but sensation of pressure m hypogastrium from within ^Btwards remained same. i6th and 17th. — 16 and 18 dr.; the colic ^Bd diarrhoea increased. i8th. — 20 dr. ; had slight colic and felt ^^K)wsy whole d. 19th. — 25 dr., after which he experienced constant gurgling in bowels. 20th, 21st, and 22nd. — 30, 35 and 38 dr., which increased colic and diarrhoea. 23rd. — 40 dr. After lapse of 2 h. colic became so violent that he was scarcely able to stand straight, and had to sic with trunk bent forward. These pains lasted upwards of an h., and diminished after a copious evacuation accompanied with emission of a quantity of flatulence. In e. pains became again more severe,

Kthouc, however, reaching former degree of violence. His sleep was ticss and full of dreams. 24ch. — No medicine was taken, colic »abated, and sleep became more quiet. 25th and 26th. — 45 and 50 dr., which again brought on slight colic, which was considerably increased on 27th, after taking 55 dr. L. now discontinued proving for 3 d. On 28th the colic kept increasing, and disturbed even his sleep ; it was accompanied with distension of abdomen and constipation. On 29th in m. he had eructations ; towards 10 great nausea with accelerated pulse, debility of limbs as from weariness, and cold sweat over whole body. This condition improved during a walk, by raising a quantity of wind. Colic, on the contrary, increased until noon, but abated towards e. In m, and after dinner he had a copious fluid evacuation. Appetite was less, sleep restless and disturbed with dreams. On 30th, in m., he had a scanty liquid evacuation ; colic was very slight and

tetite diminished. On 31st Oct. and on ist Nov. he took 60 and r., which did not produce any symptoms, but on 2nd Nov., after ig 70 dr., he had again colic and diarrhoea, which became so violent on following d., after a dose of 75 dr., that he was scarcely able to stand straight at noon. While driving home, the colic, which was now accompanied with headache and chilliness, became more intolerable. After it had lasted almost an h.,it abated somewhat after a very copious id evacuation, which was accompanied with free emission of flatuce ; but again increased towards c. Nov. 8th. — L. had continued taking the Thuja, increasing the dose by 5 dr. every d., so that at this lUte he took 1 00 dr. 1 he most constant symptom was the colic, which ased from m. until noon, intermitted after dinner, but reappeared e. and continued until midnight ; this was accompanied with sensation of pressure in hypogastric region. 9th. — IIO dr. During d. he had colic; in e. burning in eyelids, and sight was less distinct ; in n. pain in head and eyes, pressure in pit of stomach, and hurried breathing. He did not sleep till towards m., after which symptoms disappeared. loth and i nh. — 120 and 130 dr., after which he experienced burning Id eyelids with obscuration of sight ; the sleep was interrupted and

restless. The same symptoms appeared on I2th, after taking 14^ dr. In c, pupils were dilated. On 13th no medicine was taken; isodr.j which were taken on 14th, were not followed by any new symptoi

15th 160 dr. After dinner he suddenly felt a shrill ringing in r. ear,

which, after a few h., as suddenly changed to dull buzzing and groaning, latter sensations gradually changing to a noise as of a bubbling liquid, which continued all n. In e. and n. he emitted a large quantity of flatulence and yellowish wine-coloured urine ; his sleep was disturbed by voluptuous dreams ; in m. he felt excessively drowsy, and was loth to leave the bed. No alvinc evacuation. l6th. — 170 dr. The whole

d. he emitted a quantity of flatulence without any motion of bowels; his mood was especially cheerful ; he slept quietly at n. 17th. — i8odr. These caused emission of an excessive quantity of flatulence d. and n. In m. he had scanty evacuation with some colic. i8th. — 190 dr., after which he had a scanty papescent stool (after dinner) and then violent burning at anus. In e. he had colic and emitted a quantity of flatulence. 19th and 20th. — 200 and 210 dr., which occasioned nothing but colic and a liquid evacuation. 2ist. — 220 dr. That occasioned a papescent stool, a.m. In e., moderate colic, and, dunng n., constant desire to urinate and emission of a large quantity of light yellow urine. Every urination was followed by violent burning pain il urethra, and in fundus of bladder. In m. he had a hard stool, and soon after violent colic. 22nd. — 230 dr., after which colic lasted all d., the desire to urinate likewise ; the pain after urinating was, however, le$i 23rd. — 240 dr., after which he discontinued drug until 30th. During this period of time he observed following symptoms : — every d., ahef dinner, a papescent stool, with emission of a quantity of flatulence; hoarseness and secretion of mucus in fauces, obliging him to spit; obscuration of sight with dilatation of pupils and burning of eyelids. 30th. — 150 dr., after which he discontinued drug until 7th Dec. The same symptoms appeared as on previous d., but in a less degree, and they disappeared, finally, altogether. Dec. 8th, gth, loth, and nth.— j 260, 270, 280, and 290 dr. The only symptoms occasioned by thi doses was slight cotic. 12th. — 300 dr. At noon he felt slight coli in e. he suddenly felt violent pain in whole abdomen, as if all bowels were pulled towards point behind "umbilicus. This was accompanied with distension of abdomen, headache and accelerated pulse. This colic lasted 6 h., and abated gradually after a liquid evacuation accompanied by emission of a large amount of flatulence. i3ih.— j 310 dr. Colic continued until e. ; on 14th, after takmg 320 dr., experienced all d. occasional shooting stitches in abdomen. Took no medicine on 15th and i6th, and had no symptoms. From i7th to 24th Dec. inclusive, L. took a dose daily, increasing every dose 10 dr., so that on the last d. he took 400 dr. The symptoms eliat were meagre and one-sided. He was attacked with colic every d., noon and e., which increased from d. to d.,and became extremely violent on 23rd Dec. (as on 3rd Nov.). Colic abated considerably on the emission, during a walk, of a considerable quantity of flatulence upwards and downwards, and after a copious liquid evacuation at noon. P.m. and

e. he occasionally suffered from sticking, gurgling, rumbling «fld

thai

» of flatulence in abdomen, and he had a sleepless, restless n. 2t4th. — These symptoms abated ; on the 2 subsequent d.,when L. took no medicine, he complained of nothing but debility. 27th and 28th. — 410 and 420 dr. did not occasion any new symptoms ; on the following d., 430, 44.0 and 450 dr. occasioned no other symptoms than constant rumbling and shifting of flatulence in abdomen, accompanied with tooting stitches in all parts of body.

b. Persuaded that the Thuja had been prevented from manifesting its proper effects upon the organism by the rapid succession of large scs, L. discontinued proving for a icvf d., and even during first days Jan., 1845, perceived traces of the last-named symptoms. Jan. 8th and 9th. — No symptoms being any longer observed, L. took 460 and 470 dr. without any results. loth. — 480 dr. 2 h. after taking drug, he had eructations, desire to vomit, and a peculiar feeling of qualmishness in pit of stomach ; these symptoms continued until midnight, and were accompanied with constipation, restless sleep, and vivid dreams. I ith and 12th. — 490 and 500 dr., which occasioned following symptoms:— drawing and tearing in pericranium, at times in vertex, at times in occiput ; one scanty stool every d. ; confused dreams about the most absurd things. On e. of last d. burning and stinging in both eyes and eyelids, with injection of cornea ; these symptoms continued on 13th after taking 510 dr. 14th and 15th no medicine was taken. On waking on I4.th he was for a long time unable to open his eyelids. They were painful and closed again involuntarily. After rising he felt debilitated all over, especially in upper arms and thighs ; clouds and streaks (muscx volitantes) were hovering before his eyes whole d., accompanied with indistinctness of sight, which continued next d. On 16th and 17th, 520 and 530 dr. occasioned warm feeling in region of stomach; 540 dr., which he took on 1 8th, occasioned feeling of qualmishness, eructations, and emission of a quantity of flatulence. No medicine was taken from 19th Jan. until 6th Feb. inclusive. On first d. region of stomach was very sensitive, even to least pressure, especially in c. ; there was frequent and continuous rising of wind from stomach, and continual emissions of copious flatulence from rectum. These symptoms gradually abated on following days, and finally ceased entirely. Feb. 7lh and 8th. — 550 and 560 dr. j the only result obtained was eructations tasting of resin, accompanied with aversion to drug, which became so invincible that he had to conclude his provings after having taken 15,920 dr. of the undiluted tinct. in the space of 122 d. {Ibid.)

J. Landesmann, chief physician to a battalion of grenadiers, made two experiments upon himself with Thuja.

a. The unquestionable effects which L. had experienced from a few dr. of ist dil. of bryonia induced him to commence the proving of Thuja with the smallest doses of the higher dils., and to descend by ;ntlc degrees to the lower. After he had discontinued taking bryonia >r 3 weeks, and had felt free from any drug-symptoms for 2, he took, rem 4th to 20th Sept., 1844, regularly every m., i h. before a milk breakfast, 3 globules moistened with 27th dil. of Thuja (i : 100) prepared by himself 5 years before. Sept 4th and 5th. — L. remarked no

3*8

change in his sensations. 6th. — A.m., drawing tearing in r. arnii lasting several h. 7th. — Same sensation. 8th. — Drawing, sticking pains in r. index and middle fingers, gth. — Renewal of the drawing tearing in r. arm, in m. ; later, at about 10. 30, debility and lamencM in r. forearm, and violent trembling of r. hand, in which the vein* swelled without any apparent cause. This appearance lasted { h^ and disappeared while writing. loth. — Violent itching on different parts of skin, particularly on breast, with sensation as if skin at those spots was pierced with many very fine needles, which irresistibly obliged him to scratch. On e. of same d. there came on, without cause, a heavy cold preceded by dulness of head and frequent sneering. 1 ith. — At 10 a.m. sticking pain in ring-finger of 1. hand j towards noon stinging itching on breast again, and on both sides of neck, and at 9 p.m. drawing pains in 1. shin-bone. 12th. — A slight pain was observed in r. side of pharynx, extending to ear, somewhat aggravated by swallowing. i3th. — The morning pain in neck had entirely disappeared, but returned p.m., with feeling of dryness and increased thirst, and wholly vanished again in e. Remaining days presented no new symptoms. It is particularly to be remarked, however, that the catarrh was troublesome through the whole of this proving, and had this peculiarity, that it often completely disappeared for hours together, and then suddenly returned without cause, with renewed severity, and with much sneezing. From 20th to 28th L. took every m. 6 globules moistened with 6th dil., which had no other effect than that they seemed to sustain the still continuing catarrh. From 29th Sept. to 3rd Oct. L. took again the 27th dil. and of this 5 dr. every m., but without effect. Oct. 4.th, 5th, and 6th. — He took every m. 5, and from the 7th to 17th 10 dr. of 6th dil. Whereupon, besides the still continuing catarrh, the following symptoms appeared : 5th. — P.m., cutting pains in vesica for some m. 6th. — In m., sticking cutting pains in 1. side of neck, as far as 1. ear, which soon disappeared again. 7th. — P.m., drawing pain in 1. middle finger. 8th. — Repyeated drawings in I. great toe, and at n. lascivious dreams with a pollution. From gth to 1 2th, except the constant catarrh, no symptoms. 13th. — Dryness in throat ; soreness of chest, with aggravated catarrh, and in n. confused lascivious dreams. 14th. — In m. and at noon feeling of stoppage in 1. ear, with diminished power of hearing, each time lasting several m. 1 5th. — In m. distinct violent stitches from anus into region ofl. iliac bone. i6th. — At various times drawings in I. little finger. From i8th to 22nd Oct., L. took, every m., 15, and from the 22nd to 29th 30 dr. of ist dil. i8th. — The catarrh, which had remitted, became worse, with frequent sneezing. Afterward on the same d.^ p.m., a sharp lancinating pain in 1. frontal eminence, and soon after, sharp tearings in inside of r. ankle. 19th. — There were perceived, at several times, tearings in little finger of r, hand, and in c. dulness of head in front. 20th. — Frequent quiverings of lower lid of 1. eye. 2 1st. — Again, frequent quiverings of same eyelid; further, drawing in little finger in r. hand, and restless sleep with lascivious dreams. The following days passed without symptoms. But on 26th frequent quiverings came on p.m. and in e. — pulse-like Jerks in muscles of r.

3^9

arm, especially in deltoid. L. was, also, the whole d. causelessly excited and inclined to be angry, contrary to all his previous habits, 28th. — At about 10.30 a.m., while walking, he was attacked with such ^^deadly hunger that he came near Fainting, and was obliged, at a very ^unwonted time, to eat something in a neighbouring tavern. This ^^ymptom made the more impression on him, as it was repeated in e. of same and of following d. He had likewise, in r. nostril, a feeling of soreness or ulceration, which was aggravated by pressure upon the ala, but disapp>eared on following d. 29th. — L. took 40 dr. of 1st dil., but was prevented by circumstances from pursuing experiment from that d. No further symptoms developed themselves which could be attributed to the drug. The catarrh lasted until middle of December, and prover has much less hesitation in ascribing it to power of drug, because a catarrh had never lasted him so long before.

b, Feb. 1st, L. began a new experiment with the tinct., of which he took on the ist d. 10 dr. and increased the dose daily by 5 dr., so that on the 15th of the month he had reached 80, and had taken in the ^^rhole 67 s dr. Not the slightest change in his feelings followed any ^Bose of the tincture. {Jbi/i.)

^^ 9. Dr. and Prof. LiEOBECK, from Upsala, aged 42, of a sanguineobilious temperament and narrow build, often suffering from catarrhs and hzmorrhoids, made an experiment with Thuja during his residence in Vienna.

1844, Sept. 14th, he took, at about 5 p.m., a teaspoonful of the undiluted tincture. Thereafter, eructations with the taste of the remedy and, an h. later, transient pain in forehead and in 1. side of the face, a sort of twitching. — 15th. After having taken 60 dr. in m., eructations tasting of the drug, then a repeated transitory stitch in L frontal eminence, and a sensation of dryness in mouth ; after another 60 dr. taken the same afternoon, a gloomy, melancholy state of mind came on, which was still apparent on waking next m. i6th. — 70 dr. ; followed by eructations, strong aversion to meat, which had already been perceived on preceding d., difficult swallowing, without any apparent cause in the throat, stitches in both sides of thorax under mammx, both during respiration and when not respiring. The melancholy frame of mind continued. These symptoms disappeared in course of following d., excepting the stitches in thorax, which often returned and did not seem to be connected with the respiration. 25th. — L. took 140 dr. of tinct. Eructations followed, and a feeling as though perspiration was about to break out. 26th. — The same symptoms followed a like dose. It is to be observed, that the prover thinks that he passed more urine during the experiment than at other times. The departure of our northern brother in the faith unfortunately prevented the further prosecution of the experiment. {Ibid.)

kio. Dr. Maschauer instituted two experiments upon himself with e Thuia. a. 1 844, Sept. 2ist, M. began the proving with i o dr. of tinct. taken rly, fasting. He perceived no effects but an unpleasant taste. 22nd and 23rd. — T^ach d. 10 dr.; followed p.m. of ist d. by rumbling in abdomen with emission of flatulence, copious limpid urine and consti-

pation ; on and d,, scraping in throat and inclination to cough. P.nt!, the uvula seemed to be lengthened, and tonsils were vividly reddened, but swallowing was not worse. 24th and 25th, — 30 dr.; on 1st d. dryness of palate with inclination to cough, sidelong stitch in lovifcr half of I. chest; in e. aching in forehead with fiailure of sight; at n. frequent urination. On following d., continued scraping in throat with frequent cough; the headache and increased urination also persisted, and were accompanied by a stitch in I. testicle. 26th. — 40 dr. ; scraping in throat much less ; at noon, a double stitch in chest; want of appc* tite with great thirst and dryness of mouth ; at n. copious urine, with itchings in urethra. 27th. — When nothing had been taken, restless sleep, interrupted by straining cough ; the urine continued copious. 28th. — M. took 50 dr., and discontinued the dose for two days. Effects, nauseous taste ; eructations with smcIJ of Thuja ; frequent hawking with sensation as if throat were sore, continuing whole 3 d. In e., headache in vertex, remaining until midnight ; itching ui urethra when urinating; restless nights, Oct, 2nd and 3rd. — M. took on each d. 60 dr. on an empty stomach. On ist d. frequent hawking with cough ; p.m., stitches in lower part of 1. breast, and debility, with feeling as if beaten in limbs. On 2nd d,, soon after taking dose, dryness of tongue ; throughout d. much thirst and itching in anus; in e. considerable headache which lasted until midnight; constipation. On 3rd d,, itching in anus passing into a severe burning after a hard evacuation ; scraping in throat compelling him to cough, accompanied by itching in urethra. During the whole 3 d. firequent and copious urine, especially at n. 4th and 5th. — M. rested. The itching in anus occurred at times in both days, and evacuations were absent. 6th. — 70 dr. The itching in anus and the hawking and cough again became worse, — the latter with oppression of chest, which seemed somewhat to embarrass breathing ; also copious urine, hard stool, and restless sleep. 7th and 8th. — 80 dr. each d. On e. of ist d., a repeated, violent stitch in 1. side of chest j on both d., frequent raising of mucus with cough and reddened tonsils, without pain ; disagreeable itchings in urethra and anus. 9th. — After taking 100 dr., lastine pressing headache in forehead with burning in eyes, which were pained by light. Continuance of itching in anus and redness of tonsils; copious urine, failure of an evacuation (M. was accustomed to have a regular passage every m.), and a restless n. On the 3 following d. he took no medicine, and the above symptoms, except occasionally itching in anus, disappeared. 13th. — M. took again 100 dr. P.m., itching through the whole urethra during urination, and headache on awaking after a restless n. 14th. — 120 dr. The headache continaed all d. P.m., a violent stitch in 1. side of chest, increased by inspiration. Afterward, a hard evacuation with subsequent burning in anus ; urine was copious, rest good. 15th.- — 140 dr. Two h. after, a violent evacuation with bellyache and burning in anus ; in e., headache in forehead ; at n., another evacuation and rumbling in abdomen ; also, general debility and copious urine, with itchings in urethra. 16th. — 140 dr. Shifting of flatulence wiih constipation ; scraping in the throat with cough ; in e., headache followed by a restless n. During

3^1

following d., no medicine being taken, evacuations became again regular, but urine remained increased, and sleep was restless. 20th.— After taking l6o dr., no evacuation, but a strong urging towards it, with itching in anus and into urethra ; urine still copious ; in e., headache, which lasted until about midnight ; after that, quiet sleep. 2tst. — Another i6o dr. (taken fasting and diluted with water, as was always done) ; swelling in region of stomach, diminished by emissions of flatulence; p.m., a hard stool and itching during urination; in e., return of headache. On the 2 following d. no dose was taken, and no symptoms were perceived. 24th. — 1 80 dr. were followed by these symptoms : — uneasiness in region of stomach with eructations of the drug; scraping in throat with frequent cough; p.m., headache with burning in r. eye, which disappeared on repeatedly washing it with cold water ; copious urine, especially at n. 25th — M. closed his proving of the tinct, with 200 dr. After 2 h., a sudden debility with pain in calves ; then an internal chill in whole body, with dry and hot skin, which compelled him to lie down. He could not, however, keep warm in bed, and the debility increased to such a degree that he could with difficulty move his limbs. At about 10 p.m. this chill first began to disappear, merging in a dry and burning heat, and towards m. a sweat broke out over the whole body. He had no appetite, much thirst, passed no urine during the whole d., and had during the access of heat a full, quick pulse and intolerable headache. On m. of following d. he passed a small quantity of dark red urine ; the sweat continued until noon, and prover could not leave his bed on account of his extreme weakness. A chill came on again in e., followed by a sleepless n. 27th. — The debility continued ; he had no appetite, his tongue was furred, and he urinated copiously. On the 28th, for the first time, M. felt better, but could not bring himself to continue taking the tinct. ; for the simple smell of the drug disgusted and horri< fied him. 29th and 30th. — The itching in anus was again perceived and the copious urine persisted. By Nov. 8ch prover considered the action of Thuja to be exhausted, as all the vital functions were then favourably reinstated.

i>. Forty d. after last dose of 200 dr., M. began his second proving. Dec. 5th, — He took 10 dr. of the 3x dil., and increased the dose daily by 10 dr. until the 15th, without noting the least variation in his ordinary sensations. From 16th to 23rd, M. tried daily 10 dr., m. and e., of 2nd dil., with a similar want of result. From the 24th to the 27th, he took twice ad. 10 dr. of i^ dil. After doing this 3 d. in succession, the well-known itching in anus developed itself, and was especially troublesome a.m. 28th. — After twice taking 15 dr. of same dil., a slight stitch in urethra, increased urination at n., and dampness at anus. 30th. — M, took in m. 30, and in e. 15 dr. of i, dil. ; afterwards uneasiness in stomach, eructations of wind, bitter taste ; in c. violent headache, lasting until 10 ; copious, limpid urine, itching and sweat at anus. Jan. 2nd, 1845. — He observed, after 30 dr., from time to time stitches in urethra, with urgent desire to urinate, loss of appetite, vertigo, and headache in forehead in e. From 3rd to loth, M. took daily 30 dr. of i, in m., and 20 in e. The constant symptoms

were urgency to urinate, with stitches in urethra and itchings in anus. This very promising experiment was unfortunately broken off in consequence of the death of a person nearly connected with the zealous prover. {Ibid.)

II. I (Dr. Mayrhofer) proved the arbor vita upon myself and on my wife.

a. I began the proving of T. with the 2nd dil., making no change^ in my manner of life. Sept. 8ch, 1844. — At 3 p.m. 1 took 50 dr. without experiencing the slightest change in my sensations ; 1 00 dr. taken early, fasting, on 9th, produced no further effect, nor did 150 more taken in c. of same d., or aoo dr. taken on loth. I tried then, on I ith, at 6 a.m., 100, and in e. 200 dr. of ist dil., wichout observiag any morbid phenomena. 12th. — The want of susceptibility of my tough system to the power of the dilutions determined me to try the undiluted tincture, of which, on this d,, I took 50 dr. m. and e. each, but waited yet in vain for any signs of life in the "tree of life." I3tli. — After 100 dr. taken early and fasting, I first perceived, during d,, swelling of haemorrhoidal veins, with tenesmus, itching, and burnitig in anus. In e., on repeating the too dr., I had 2 slight passages, ending with discharge of mucus, itching, and burning. 14th. — In m. 100, and in e. 200 dr. The itching and burning in anus increased, and were especially troublesome in e. after a stool. During n., more frequent and copious urine than formerly, and, immediately after urinating, I felt a renewed inclination, whereby a few dr. were dis. charged without pain. 15th. — 200 dr., taken both m. and e,, produced no new symptoms. i6th. — At 6 a.m., 300 dr. Immediately afterwards, nauseous taste and confluence of much saliva in mouth. After \ h., dull headache over whole frontal region (lasting an h.). At 6 p.m., a stool, with subsequent burning in anus, and shortly after a reiterated discharge of mucus, attended with very violent stitches in rectum in direction of a line from anus to sacrum. As the stitchei ceased, the itching and burning returned, and lasted until 10. 17th. — 300 dr. Itching and burning in anus remained the prominent symptom, lasting till midnight and preventing sleep. Three stools followed, ending always with discharge of mucus ; urine was plainly increased, and after urination the inclination returned, attended with the voiding of a few dr. more. 18th, — At about 6 a.m., 600 dr. were taken in a glass of water, with the following result: Eructations of the drug for some h., confluence of saliva in mouth, headache in frontal region, and in e. 3 stools, with subsequent itching and burning in anus and irritating stitches up rectum. On following d., on which I took no dose, I frequently felt flying stitches under r. shoulder-blade, and in e. had 3 stools with the accustomed accompaniments. As in course of 20th, the following d., 1 perceived no drug affections, I took 400 dr. at about 9 p.m. Before midnight sleep was destroyed by emission of much flatulence, by itching and burning in anus, accompanied by flying stitches in rectum and by repeated urination ; sleep, however, came on after midnight, and on awaking I found myself better than I could have expected after a bad n. I took no medicine on the next 3 d, ; regularly every c. the itching and burning in anus set in ; every d. aJso I

^ud 2 stools ending with discharge of mucus. 23rd. — In e., 500 dr. Increased warmth in face with dull confusion in head (effect of the alcohol) ; unrefreshing sleep, interrupted by terrible dreams (of the dead) and by frequent urination. On following m. dull confusion in head, with general debility. Through d. flying drawing pains in various parts, especially in hands, and in e. return of itching and Wning in anus. From 25th to end of month I ceased to take the drug, and made the following observations : On c. of 26th, 3 round red spots size of a lentil, which itched and obliged me to scratch, appeared on inner surface of r. forearm near wrist. The itching became burning when they were scratched. On following m. they had disappeared without leaving a trace ; on 28th I remarked a painful tubercle of about the same size in neighbourhood of anus, on raphe ofperinaeum, which likewise disappeared in a couple of d. Flying drawing, now here, now there, and troublesome itching in anus, especially in e., developed themselves every d., gradually, however, wearing off. Oct. ist. — At 5 p.m., 500 dr., followed by nausea, eructations of the remedy, and (after ^ h.) itching and burning in anus. During n., discharge of much flatulence and copious urine; at 6 a.m. of following d. an evacuation with burning in anus ; through d. felt well. 2nd. — On taking 500 dr., the constant burning and itching in anus reappeared, and night's rest was as usual disturbed by frequent urination and restless dreams. On following d., no other symptoms were perceived except debility and occasional flying stitches in rectum. 4th. — I took, at about 3 p.m., Mother 500 dr. In e. dull confusion of head and burning in anus ; on lollowing n. abundant urine, much flatulence, and dreams. On following d. I felt pretty well again ; while urinating, however, I made the ""pleasant discovery that the glans penis was entirely covered with a f'^cnish-yellow, ill-smelling secretion, and after I had cleansed it, I observed on dorsum of glans, near hinder border, 4 tubercles about size ^''> flaxseed, with a vesicle on their summit, and in the sulcus, near ^'f^chment of foreskin, was a small eroded spot, surrounded by a red 'J"^*^le, about size of a lentil. 6th. — Nevertheless, I again took 500 '^■> upon which the symptoms already described again appeared, and I ^ tubercles on the glans had increased by 2. The urine, since the ^'"ge doses, had become turbid, and, in cooling, deposited a flocky, •"Ucous cloud. Urination was performed without pain, but a sensation ^s often experienced, while seated, as if the glans had been bruised. '^•^, — No new symptoms were developed by a fresh dose of 500 dr., ^^«pt that the vesicles of the elevations before described were broken, ^<1 left behind little painless erosions, surrounded by a red margin, and ^.' aiding the secretion alluded to. During the 3 following d. no medi- ^■^«was taken, and the protuberances became flatter, the areola paler, and ^^ last the sore spots disappeared also. Pains, at one time drawing, at ^^c»ther tearing, were repeatedly felt, especially in extremities, for the ^'^'^st part while at rest, but In r. tibia also while walking, so as to "^^kc me limp. ilth. — At 3 p.m., 600 dr. Besides the usual phcno- °^^na, I noticed on the following d. granular, elevated red spots on the E>%iu penis, which was uncommonly sensitive, and on 13th sebaceous &**nd9 of prepuce appeared swollen and inflamed ; but, on 14th, the

inflamed spots were paler again, the clustered, prominent tuberdes flatter ; and on I5lh appearance of prepuce and glans was again natural. i6th. — At 3 p.m. I drank looo dr. in a pint of water. Immeiliaiely afterwards, nausea with vomiturition and confluence of saliva in moulh. After an h., headache in frontal region with heat in cheeks ; and, { h. later, general feeling as if beaten, with chill over whole body in so remarkable a degree, that I was obliged to go to bed, although it wa only 6 p.m. The n. was disturbed by many dreams and frequent urination. On the 3 following d., no medicine being taken, I felt uncommonly debilitated. I was especially annoyed by itching and burning in anus, attended by several violent stitches in rectum (particularly in e.). I also had, at times, drawing pains in hands and feet, which still continued even after 8 d., growing, however, weaker anl weaker. No change was perceptible in the glans penis, but 1 felt a burning pain in perinxum, raphe of which was more prominent thaa usual, and one inch from the anus a tubercle size of a pea appeared, which increased for 3 d., became moist, smarted in walking, and then day by day became smaller and disappeared in about 10 d.

i. Nov. 8th. — After I had desisted for three weeks, and felt myself pretty free from the effects of the drug, I began a new proving, by taking 300 dr. of the tinct. at 4 p.m.; whereupon the well-known Thuja symptoms made their appearance, as transitory drawing, perceptible now here, now there, itching and burning in anus, copious urine, sensitiveness of glans, &c. Qth. — 300 dr. in e. In n., increased sexual desire, which, during the whole course of preceding proving, had been rather diminished than exalted. lOth. — On following d., soon after waking, I was annoyed by an itching, burning pain in hollow below OS coccygis, lasting all d. j the same phenomenon recurred on taking 300 dr. in e. Three d. subsequently glans became sensitive, and sebaceous glands of the prepuce swollen, as on I2th Oct. On the 4th d. I remarked a red tubercle between scrotum and r. thigh ; violent itching in hollow below os coccygis was again very troublesome, and the anus became as sensitive after a slimy discharge as though the skin were cracked and chapped there. 19th. — When most of the Thuja symptoms had ceased, I took at about 3 p.m. 1200 dr. of tinct. (in weight ^^j and 3ij) in a pint of water. The effect of this draught was at first the drunkenness induced by alcohol ; heat in the head and face, uncertain gait, reeling of surrounding objects, &c. In e., a general feeling as if beaten, which drove me to bed at 8 p.m. Sleep was interrupted, as before, by dreams and frequent occasion to urinate. On following d,, besides the occasional drawing in limbs, I was annoyed by my most constant Thuja symptoms, itching and burning in anus with tenesmus, especially in e. 23rd. — Deep red spots showed themselves on glans, and inner surface of foreskin was inflamed and swollen. 24th. •^The 5th d. after the large dose of Thuja, a slight burning pain was perceived in glans, which in the furrow behind the corona was entirely covered with a thin, yellowish, ill -smelling secretion, on the removaiV of which two deep red spots were discovered, which appeared to be eroded, and from which the fluid alluded to transuded. 2Sth. — The two spots had increased in size, run together, and were covered with

(

granular elevations ; the glans was rendered uncomfortable, but urination was performed without pain. 26th. — The whole furrow as far as the ftcnulum was sore and covered with papillx size of a poppy-seed. The lecretion from the glans was very copious. 27th and 28th, — Secretion «» diminished in quantity, but some twelve or fifteen reddish excrescences arose on the hinder border of the glans, largest of which was about the size of a flax-seed ; and inner surface of the prepuce was full ofgrtnular tubercles. On next d., elevations on glans disappeared, as vrell ai sore spots in the furrow, with a steady diminution of the purulent discharge ; sebaceous glands of the prepuce remained, nevertheless, ^^foriome time swollen and prominent.

H^ c. Dec. 1st. — At about 3 p.m. I took 3 dr. of oil of Thuja on a ^Itnnpof sugar; the oil had been obtained (jj from 4 lbs. of leaves) by distillation of tender twigs of the tree; it tasted exceedingly sharp, ind caused eructations for several h. In n. frequent urination, with wy hasty, incessant urgency, and on following d. redness of glans at Jperture of urethra. After talcing 10 dr. of the oil in e., the eructations continued into n. 3rd and 4th, — A dull pain developed itself in I. testicle as though it had been bruised, and was perceptible both when seated and when walking. On 6th an eroded spot appeared apin in middle of furrow of glans, which discharged a pus-like fluid. ^thandSth. — The discharge from the glans had attained its former '"'tight, The whole furrow was covered over with pus, so that it was necessary to cleanse it often. 9th. — After moderate use of wine the condition was still worse. The inner surface of the prepuce was sore ■Dtpots, highly inflamed at frenulum, glans was sensitive and painful *hen walking. I was now content with the painful present thus nude to me, and closed my proving of Thuja. The discharge from the glans was not entirely cured, after several alternations of better ud worse, till end of 4 weeks. Itching and burning in anus lasted 'ongest, and was still felt at times after the lapse of months. I must ^n repeat the observation that during the whole duration of the Kxperiments with Thuja [unica mete exempta) the sexual impulse was diminished even to indifference. {Ibid.)

1845, June 17th. Maria Anna M — •, 35 years old, sanguineo-

■"melancholic temperament, tall and slender form, mother of six healthy

^ildren, began the proving of Thuja, 4 months after the birth of her

V"t child, by taking 200 dr. of the 2nd dil. This was at about 3 p.m.,

^^^ experienced no effect from the dose, nor from another of 20O dr.

^^hz 1st dil. 19th. — P. m., she took 30 dr. of tinct., and on awaking

■""^t in. complained of painful tension in I, side of neck, darting up-

y*^* to cxrciput and downwards to the scapula, and preventing her

^'tj turning her head. On 20th (on which d. she took nothing) the

'^lajon seemed somewhat to remit, but returned in greater severity on

.''•*, after uking 40 dr. In c. there also came on a crushing pain in

**er side of 1. wrist, in head of radius, which last was plainly swollen

f^*^ painful to touch. 22nd. — P.m., she took 50 dr. In e. she felt

l**^sion in both knees and heels, especially when rising after being

'^'^g seated. The stiffness of nape of neck continued. 23rd. — The

'^^^e symptoms continued on taking 60 dr. She compared the tension

in knees and heels to a feeling as if feet had been rendered irtil over-exertion in walking. She took nothing on the last days of June and the tension in nape of neck and in knees and heels diminished, bul did not altogether cease. July ist. — After a pause of 8 d. she tinued the proving by taking 70 dr. of tinci. The tension patellae and in heels (at point of attachment of tcndo Achillis) imi diately increased. The rest at n. v^as good, and no change was ceived in urine or stools. 3rd. — 80 dr. were taken in afternoon ST usual, upon which a dull stunning headache, in frontal region uui vertex, came on, which, however, did not last long. Sth and 8d| — Nothing new was produced by go and 100 dr. The tension fl knees and heels continued, but was only troublesome while walking, not while sitting ; the tension in nape was still occasionally scnMbIc, especially in m. gth and loth. — 120 and 140 dr. of tin ct. having been taken, no new developments occurred, and the prover, stifFened in neck and legs, concluded her experiment. 12th. — The mcnw appeared at their regular period, but were weaker than ordinarily. Tfc stiffness of 1. side of neck, and the tension over knees and in he diminished only very slowly, often disappeared and then suddenly! in again, and first completely vanished at the expiration of 3 mond {Il^id.)

Dr. Reisincer. instituted on himself three experiments ffitl Thuja.

a, 1844, Nov. 5th. — R. took in m. 10 dr. of tinct., and increased 1 dose daily until he arrived at 100 dr., which he then repeated every I other d. until 1 0th Dec, without experiencing the slightest influence.1 Various hindrances prevented the prosecution of this experiment.

b, 1845, March 1st. — R. recommenced proving Thuja with l" dr. of tinct., and added lOO dr. every other day, so that on 15th do was 800 dr. The sole symptom which he ascribed to the drug w»' tolerably strong, jumping, sticking pain in a hollow tooth of I. un ' jaw, which had never ached before. 1 his pain appeared only up d. of taking drug, and about 3 — 4 h. after its administration. Buttiiill very probable symptom of Thuja disappeared again under the sul»^| quent remarkably large doses. 15th. — After taking 800 dr., R. j*''] ceived in e. slight oppression of chest, with inclination to cough. i/i"i 19th, and 21SC. — 1000, 1200 and 1500 dr. produced no effect whaH ever. R. now discontinued the doses for 8 d., and waited, but I'l vain, for the after effect of the remedy. 29th, 30th, and 31SI.— Hij took, each d., 1500 dr. of tinct., and remarked afterwards slip vertigo (effect of the alcohol), continual eructations, dryness of [ frequent hawking up of mucus, and pressing, tensive feeling m lungs, that became more perceptible and sticking on taking » d«?l inspiration. The other functions remained normal. April isl.-'l Encouraged by this impunity, R. took from 1st to 5th April, in dwn increasing doses, 1600 to 2000 dr. of the tinct., without perceiving^'' slightest change in his sensations, except a feeling of dulncss andi fusion in head. gth. — R. drank at one draught ^'j of tinct. Oft^ subsequent symptoms, the increased warmth in the stomach and wh frame, the vertigo, the headache in whole frontal region, and the vio

phirynJj

', are rather to be set to the account of the alcohol. Thuja will

the credit of the following : Swelling of the veins, especially of

aim ; eructations of wind, smelling of the drug ; oppression of

chest with some pain on inspiring ; frequent hawking up of a

gh mucus i restless sleep with confused dreams and excited sexual

pulse.

f. As was to have been expected, no results followed an experiment titutcd by R. with the first twelve dilutions (i : 99). He began with 100 dr. of the first dilution, and took daily the same quantity of the succeeding dilutions in regular order, closing his resultless experiment with 100 dr. of the twelfth. He had now taken some 25,000 dr. of the Thuja tinct., and was well weary of it, but not ill. [Ibid.) If. Dr. Sterz made two short experiments with Thuja. fl. 1844, Oct. 13th. — He took tinct. every forenoon between 10 and II, upon a lump of sugar. He began on 13th Oct., 184.4, with 5 dr., took 10 on 14th, and increased dose each d. by 10 dr., until, on 19th, he took 60 dr., but perceived not the slightest effects. 20th. — An h. after taking 80 dr., a sensation of roughness in throat came on and lasted until midnight. 2lst. — 100 dr. Immediately after dose, ^^ietiing of roughness on tongue, hard palate, and in throat ; at noon ^■ensitiveness of gums of molares ; at 7 p.m., colic-like pain in hypo- ^Rutrium and movings in the bowels as if preceding a diarrhoea, which, B indeed, came on very violently at 8.30 with severe bellyache : the pains ^ then remitted, but the hypogastrium remained tender for several h. I His sleep was quiet after midnight, and towards m. much flatulence wu discharged ; the throat was still rough and fauces dry. He was ' 'tquently obliged to hawk and throw off white, tough mucus. After <oa,m. he took a fresh too dr., upon which, frequent eructations with iJuseaj at noon, dull confusion in forehead, which disappeared at oiidnighi i in e. a copious evacuation, with discharge of much Aiitulence. All the morbid sensations had vanished on next d. after a L^mct night's sleep.

^H h. Dtc. 7th, 8th, 9th, and loth. — No effects were perceived from ^'toodr. of the isth dil.* (the dilutions were prepared with one part of *lcohol and four of distilled water) taken daily, nor from the same Sumtity of 12th dil. taken on nth. 12th. — S. took m. and e. 200 dr. of lith. At noon feeling of dryness on palate, and next d. drawing in IfKli thumbs on awaking, 1 3th. — 400 dr. of 1 2th. Thereupon rough- Oess of palate and drawing in r. thumb, which last continued alld. l4th.~Nothing new was developed by 400 dr. of 8th dil. The draw- ^^gin r. thumb extended into the wrist-joint. On 15th no dose was ^Bwen, and except dryness of the throat no symptoms appeared. 16th. ^r^OO dr. of 6th dil., which were repeated on 19th ; after which, ^•ti^ping and roughness in throat, and drawing in r. knee. After a piuse of 28 d., S. also experimented with the 4th and 2nd dil. 1845, ^J"n- l6th, i8th, igth, and 21st, he took 400 dr. each d. of 4th ; and Hp 5th, 6th, 7th, and 8th Feb. 200 dr. of 2nd. The following slight ^'•ymptoms appeared : Feeling of dryness in throat, with frequent hawking and spitting of a tough white mucus and confluence of much saliva * The dilutions were all decimal.

*'0L. IV.

into mouth ; the taste was injured by it, and food tasted as if i not salt enough. [Ibid.)

Wachtel proved Thuja in the dilutions only.

a, 1844^ Dec. 1 0th. — Our associate, so remarkably sensitive to the effects of this drug, began his proving by taking 30 dr. of the 3X dil. about an h. before breakfast. He observed, in forenoon, a sudden thrust from before backwards in r. half of chest ; at noon, complete loss of appetite ; in afternoon, itching and biting in prepuce ; afterwards, tearing pressing in upper part of r, thigh and 1. arm, which grcatljr resembled the effects of bryonia, with this difference, that the pain produced by Thuja seized the middle of the affected member, was confined to a small spot, and was mostly in the muscles, while that produced by bryonia seemed to prefer the joints and tendons. In e. be felt maddening twitching in r. frontal eminence. An h. later this piin attacked the r, eyeball much more violently, but shortly disappeared, leaving behind a sensibility of the eye to touch of hand, which remained a long while. Sleep of following n. was good ; but immediately 00 waking the same pain re-established itself in r. eye. i ith. — 10 dr. of same di),, producing return of chest>pain of d. before, but this time in 1. half. Afterwards, an unsatisfactory, hard stool, with subitching and biting in anus. P.m., drawing through whole L; the outer surface of thigh ; in e., pressing pain in frontal and occipitil regions ; itching in corona glandis when walking (for \ h.). His sleep was good and comfortable, with lively and pleasant dreams. Feeling of health on awaking, except weariness and lameness in legs. On 1 2th, no striking symptoms followed repetition of dose; W. onlf remarked in middle of 1. parietal bone a spot, size of a sixpence, sensitive to touch, and a drawing from crest of r. iliac bone to upper part of thigh. 13th. — Pressing in occiput was only symptom after taking 10 dr. On 14th, after a similar dose, pressing in fore- W. now discontinued the Thuja from the 15th 7 th Jan., 1845, in order to see how long the would continue ; and acknowledges his astonishment at the duration of its action. During this time he observed the following symptoms : ii|th. — Violent drawing and pressing in sacnl region for 2 h. in forenoon. On l6th, while writing, drawing pressing in r. thumb (for 5 or 6 m.) ; then in index ; later in middle, and finally in little finger. In afternoon same sort of pain appeared in 1. arm, shifted then to upper part of thigh of same side, soon after appeared in both mastoid processes, then in frontal eminences, where the pain took more of a digging-twitching character, and finally reappeared in extremities. This wandering about of the pains continued through following d. On 18th, for several h. in forenoon, the pain remained in neighbourhood of 1. wrist ; and, during whole afternoon, in upper p»n of 1. thigh. 19th. — While lying down, the pressing in sacrum wai fixed iu same spot for a whole h. It diminished and disappeared on motion ; but afterwards appeared while lying in bed in lower part of 1. thigh, in the same spot where it had already appeared once before. The prover remarked this d., on edge of upper lip, two small, dark rcii, burning spots, size of a lentil ; on which, during the 3 following d.,

head, lasting all d. Dcc.^ 1844, until effects of the drug

spc

tir

re elevations were developed, which dried up and fell off. Later, ) new spots appeared, which ran same course. He observed, in dition, feeling of stiffness on side of the nape of the neck, which had en already perceived during the first days of the experiment, but had en attributed from the beginning, by the prover, to an uncomfortable sition in bed. 24th and 25th. — W. was often tormented by a very painful tearing drawing in I. chest, in neighbourhood of fifth and sixth ribs. This pain appeared when standing and sitting, disappeared when moving, and was rather diminished than increased by a deep inspiraon. 26th. — Crawling drawing in 1. zygoma, which left behind for a ng time a feeling of deadness. This symptom appeared again on 27th, on same, and afterwards on r. side. In e., drawing tearing in mastoid process of 1. temporal bone, and then in both eyeballs, where the pain ceased. 28th. — Prover was annoyed through whole d. with a crawling pressing pain in I. side of sternum, which was confined to a spot about size of a thaler, remained the same in rest or motion, and '^"finally left the feeling as though spot was sore. After 3 weeks lated symptoms were still perceived. The pains were, for the most rt, drawing, tearing, or crawling, seldom pressing, and least of all ticking. They were mostly confined to a small spot, seldom continued long, frequently changed their location, and came on distinctly when ar rest as well as during motion.

b. 1845, Jan. 8th, — After W. had almost ceased to perceive the symptoms produced by the proving of the 3rd dil., he took, at 7 a.m. this ., 3 oz. of the I2X dil. In 1 1 h. afterwards appeared (weakly marked) the characteristic tearing drawing pains, sometimes in frontal eminences and occipital protuberances, sometimes in middle of 1. arm and thigh (only when at rest). The crawling and drawing in both zygomata, and in I. upper maxillary bone, came on instantaneously, and disappeared again as rapidly as it had appeared. 9th. — Rather violent drawing in r. shoulder, and later, without the slightest cause, cutting and griping in 1. side of abdomen. loth. — No abnormal sensation was perceived, but on ilth extraordinarily violent tearing in 1. concha, and soon after in 1. eye, which ended with a darting stitch through middle of eyeball. Copious urination also came on. 12th. — Prover remarked in region of heart a small spot, sensitive to touch, with pain as if it were sore, and on following d. a similar spot upon vertex, on which skin was somewhat reddened. At lO o'clock he went to bed in good health, but after i h. was suddenly seized with anxiety, after which a slight perspiration broke out ; whereupon he fell asleep, but continually stirted up again. Finally, drawing pains in arms and legs, and especially in sacrum, came on. These having ceased, he had quiet sleep till m. 14th. — W. found himself tolerably well ; only general weakness and frequent accesses of drawing pain in different parts of body annoyed him. In e. the general debility increased, and he was obliged to go to bed at 7 o'clock. After some m. his feet became as cold as ice, whereupon he became again anxious. It was a very striking symptom that in no position of the body, whether sitting or lying, could he feel the pulsation of his heart. Slight shiverings, which spread themselves by little and little over whole body, came on.

At last, after J h,, he experienced a trembling of the heart, after which a general sweat broke out, so that in the course of a m. whole body was wet. This was followed by dozing for an h., unrefreshing, and disturbed by frequent starting and horrible images. When he awoke from this he was tormented with drawing and tearing pains in hands and feet, and when these last suddenly disappeared, the anxiety and heart-trembling returned. It was only after i h, that his heart again beat regularly ; but then drawing tearing pains in epigastrium, in hypochondria, on chest, but worst in sacrum, came on, ending in a slight perspiration, and finally in sleep. On awaking, W. was very weak, and every part of his body felt as though it had been bruised ; head, however, was free from pain ; the weariness, too, nearly disappeared in course of d. 15th. — He went to bed later than usual. After he had lain quietly for a ^ h. his feet began again to grow cold, anxiety again came on, and in an instant, in place of the regular beat, he felt a trembling of the heart. The sweat that then broke out was interrupted by the prover's being called to a patient : on his return at the expiration of an h., he slept tolerably well until m, i6th. — During d. drawing pains, now here, now there ; weariness, with apparent loss of sensation in limbs ; in e., after lying down, cold feet again, with anxiety and palpitation, but less in amount and of shorter duration. Isolated symptoms were still remarked by the observant prover six weeks after the 3 ounces of the 12th dil. had been taken. The following were daily visitors, — the drawing pains in hands and feet, in sacral region, and between the shoulders. The crawling drawing in zygomata and the tearing in occipital protuberances and in petrous portion of temporal bone were among the oftenest perceived. No chest or abdominal symptoms appeared, but wart-like excrescences frequently appeared on back of r. hand, on chin, and other places. A furunculus behind r. car especially continued a long while, and formed a scab, from which exuded a glutinous moisture. This soon dried and fell off, when another formed ; it was sensitive to touch, and lasted 4 whole weeb. Finally, W. repeats the observation that the symptoms of Thuja came on almost exclusively during rest, remained but a little while, and were either rendered worse or caused to break out afresh by the use of spirituous liquors, except the customary beer. [Ibid.)

Watzke instituted four experiments with Thuja; and of all the drugs which he has assisted in proving. Thuja seems to have found the least sensibility to its specific effects in him. He experienced no regular drug sickness, although isolated Thuja symptoms were clearly developed.

a. 1844, Nov. 26th and 27th. — '* I took,*' says W,, "on these days, twice in the forenoon, 6 dr. of the I2th dil., and during the two following d. the same dose in like manner of the gth, and observed a strict diet. Whether the symptoms which then appeared were certainly produced by the Thuja or not, I do not know ; but of this I am confident, that they were such as I had never before experienced, and such as almost constantly returned when I subsequently experimented with larger doses of the drug. There appeared, especially during the time of proving, repeated, short, dry cough without throat

34«

symptoms or pain in the chest. The h3'pogastrium appeared the whole time somewhat inflated and sensitive to pressurCj and even to tiiejarof the foot on the ground. It seemed to me as if I perceived the vesica to be larger, and I was obliged to urinate oftener than usual ; but neither had I pains in the urethra^ nor was the urine at all changed. From 2nd to 14th Dec. I took nearly every d, a dose of Thuja ; until the 6th, 6 dr. of the 9th ; until the loth, 6 dr. of the ' 6th; and on the 13th and 14th, 6 dr. of the 3rd dil. Although during this time I did not altogether observe a strict diet, still some certain symptoms of Thuja manifested the working of the drug ; certain because they were renewed with renewed intensity under the larger doses. These symptoms were dry cough ; pain in the patellae, Frequently returning whether sitting or walking, a twitching as if a tendon were slowly drawn out and then suffered to return ; a similar pain in temples; outer malleolus of r. foot was painful while walking, as if after a false step ; circumscribed pain in inner side of the thigh, Sfcs if after a long walk; swelling in region of hypogasirium, with Frequent urgency to urinate.

"^. From 19th Dec, 1844, to 2nd Jan., 1845, without changing rny ordinary mode of life, which was not confined to a very severe diet, I took, at about noon of every other d., a dose of the tinct., k>cginning with 10 dr., and increasing it each time by 10, until, on the Jast-named d., I arrived at 80 dr. The abnormal sensations which I experienced during the duration of this experiment were the following : Contractive pain in r. temple, pretty severe, often returning and always •asting several seconds j pressure in r. eyeball ; biting in corner of r. *y«. Once at about 5 p.m. (without any cause affecting the eyes) the *surrounding objects, which I wished to regard, suddenly swam before '''y eyes i I could not see clearly, much less read. This lasted nearly * h. Sensitiveness of isolated spots on thorax j feeling of weight, and "^uent cramp-like constriction in chest ; dry cough, increasing in •^'fect ratio with duration of experiment, becoming constantly more *'oub|csomc, and finally obliging me to lay aside the proving for a ^liile; sensitiveness and feeling of inflation in region of vesica with '^frequent urgency to urinate ; violent itching in distinct points on inner *side of thigh and on parts of genitals covered with hair j sensibility of K'lns and darting stitches through it ; remarkable indifference to the Opposite sex ; several times, on awaking, drawing pain in great toe ; ■feeling in little toe as if skin were lacerated in spots ; weariness of °*er limbs, especially remarked in the lower part of the thigh.

'*f. From the i6th to and including the 20th January, I took daily

'Oo drops of the tincture without noticing any new symptoms ; those

'^eloped under the previous proving again appeared with less violence,

^'•^ept the dry, frequently returning cough, which rendered me so

"*^ious about mv health that I was induced to discontinue the experi-

*^</, Feb Sth. — I took 150 dr. of tinct. ; on 6th, 300; on 7th, ^5^ ; on Sth, 600 1 on 9th, 700 j on lOth, goo : each time between '® and II a.m. These doses produced nothing new j they simply *^*U^sed tnost of the symptoms developed by the second experiment to

return more markedly, and with greater force. The last dose 900 dr. was followed, during whole afternoon, by frequent eructations of food with taste of drug, and several times by violent^ nearly watery, but painless diarrhcea.

" e. On Feb. 2Sth I took in the forenoon two, and on the 27th three table-spoonfuls (about 1350 dr.) of the tinct., at the same time observing a strict diet. The somewhat numerous symptoms that constitute my last proving began to appear for the most part some hours after the doses, and connned themselves principally to the first 24. or 48 h, ; but, nevertheless, they did not run an acute course, nor vanish, like meteors, after a single appearance, but returned separately during a period of from 8 to 1+ d. They seemed to have a chronic character, and a marked though irregular periodicity. It was more especially i.-pon the thoracic organs, as in the former provings, on the muscles, head, especially occiput, and upon the organs of generation, that Thuja exerted its influence. The peculiarity of the muscular pains was that they generally affected the middle instead of the tendinous portions of the muscle. Most of the symptoms came on during rest, many of them on waking in m. To prevent a tedious and unnecessary repetition, I confine myself to a description of one d., the 27th of Feb., which was one of the richest in symptoms. At ll a,tn. I had taken 3 tablespoon fuls of tinct. Immediately after dose, head felt cloudy, I felt my spirits excited and became lively and loquacious (effect of the alcohol ?). Soon I perceived a slow-drawing, sometimes darting pain in r. half of face, from temple to teeth ; then the whole became sensitive, and increased in sensitiveness with the subsequent symptoms in course of afternoon. Occiput was externally warmer to touch in a particular spot, corresponding with which I felt heat and pressure in brain. At times dull stitches ran through brain, generally in direction of eyebrows, and from eyeball to occiput. Chest smarted internally, as if sore, especially during the dry cough which appeared from time to time. In some spots I had a feeling as if thorax from without, and corresponding portions of lungs from within, were strongly and continuously constricted; a feeling which returned frequently and strongly on the following days, especially during rest, induced frequent deep sighing, and annoyed me not a little. There were spots here and there on thorax and extremities painful as if from a thrust, cspcci»lly during movement. In other spots I perceived a stitch, leaving behind an itching, as if they had been bitten by fleas or ants ; in forearm several times a coursing and gurgling, as of single drops of blood rolling one after another. I had frequently, for a m. at a time^ a pain which in axilla, in dorsum of foot, and on various points of external chest, was pinching and pressing, in patellar and heels was stinging, and in extcrnil ear compressing. Violent twitching came on in isolated muscular parts, which was strongest in the middle of upper part of r, thigh and of 1. arm. In ends of fingers and toes, twitching was finer and morr transient. This muscular twitching was frequently repeated on the following days in different parts, and was one of the most troublesome symptoms : for example, it still came on on 13th March, and lasted for almost 10 m. in chin. The stinging pain in heel often returned,

liking (for \ h.). Inner side of

was especially troublesome ii upper thigh and parts of genital organs covered with hair were very unpleasantly affected with itching and scraping, frequently lasting from 5 to lo m. Frequent stitches darted through glans and whole member, especially glans, was constantly sensitive. An uncomfortable sensation of fulness in region of bladder forced me to frequent urination; quantity of urine did not seem increased, and quality was perfectly normal. My digestion and evacuations seem to have been left nearly or quite undisturbed. The most lasting and most troublesome symptoms in my case, as may be gathered from foregoing account, were those which affected muscles and chest. The dry cough, the constriction in spots on thorax and in corresponding parts of lungs (frequently returning, very irritating and annoying, compelling frequent deep inspirations, and ameliorated by wine and beer), only entirely disappeared in course of about 8 weeks. The striking indifference to sexual intercourse, by no means customary to me, continued during the whole experiment, and, in fact, still longer." {Ibid.) fj. Dr. WuRMB instituted 5 experiments with Thuja, 4 with the tinct. and i with dils.

a. 1 844, Sept., W. took, from 17th until and including 21st, at about 5 p.m. of each d., a coffee-spoonful of the tinct. of Thuja ; omitted it on 22nd ; took same dose at same hour on the two following d. ; omitted it on 25th ; and from 26th to and including 30th again repeated it. The 'following were the results. i8th, — in m., after urinating^ burning in urethra j very painful stitches from urethra to anus ; pressing in region of neck of bladder, with urgency to urinate. These feelings, which prover thought similar to those usually perceived at the beginning of a clap, or after drinking new beer, lasted about 20 m. 19th. — Soon after dose, tearing in outside of r. ankle; then in I. elbow ; then drawing in inner side of upper thigh, and finally tearing in 2nd joint of r. thumb. On 20th, soon after dinner, violent pressing in 1. temple, which continued all e., but in less degree. During proving the stools were softened, more copious, and took place from 2 to 3 times a d. After a cessation of 8 d. W. took from 8th Oct, to and including 14th, at 5 p.m. eachd., 2 coffee-spoonfuls of tinct., with following result: ilth. — Soon after dose, feeling of roughness in throat, lasting some h, ; pressing in r. chest, particularly noticeable when breathing deeply, and when bending body ; at 7 p.m. drawing in ist joint of r. thumb, especially during rest, instantly disappearing on moving finger, and returning as quickly on cessation of motion. This symptom continued nearly i h. ; several times drawing in 3rd joint of r. ring finger, and pressing to the 1. under short ribs. 1 2th. — The pressing pain appeared at lower extremity of r. chest, after getting up ; it was somewhat violent at first, but decreased very much during the d., without, however, entirely disappearing. In m. a very copious soft stool. In e., on going out, after taking drug, vertigo, drawing in inner surface of r. thigh, in r. knee, in r. calf, in bend of elbow, in both popliteal spaces, especially 1. The feeling of roughness in throat was less than d. before. 13th and 14th. — The sexual impulse was exceedingly importunate (without any known cause).

34+

He thinks he passed more urine than usual. 15th. — Frequent, and on every occasion copious urination. i6th. — The prominences of r. elbow were painful, as if after a severe knock, and this feeling did not entirely disappear until i8th. From 20th to 30lh W. took daily, at 9 ».ni. and 5 p.m, 2 cofFee-spoonfuls of the tinct.,and observed as follows; On 22nd, in m., after getting up, painful drawing in 2nd joint of I. thumb (only during rest) for about 2 h. The same feeling, but not lasting, and much weaker, appeared in course of forenoon in almost all finger-joints (but only during rest). For an instant this drawing appeared in inner side of 1. foot, as far as sole. In m. he had th( usual, and at 1 1 a.m. a papescent stool. At 6 p.m. sudden drawingon inner side of I. foot in metatarsus. 23rd. — No evacuation. In e., before going to sleep, drawing in 1. side of neck. Restless night; he awoke at ^ a.m., and for i h. could not go to sleep ; then fell into 1 sleep which was interrupted by frequent waking. He had besides » feeling of stoppage in r. nostril, with frequent sneezing and chilly feeling in feet, which were externally warm to touch. 24th. — Immtdiately after getting up, a very troublesome drawing in I. side of neck and in 1. shoulder, which only disappeared p.m. At 10 a.m. drawing in r. heel, and, ^ h. later, in r. index finger (disappearing tnstantljr on movement). Symptoms of nose continued, with dull confusion in head. As W., according to his own observations, is but little sensible to changes of temperature, and can trace no cause for this cold, he thinks that these symptoms must be ascribed to Thuja. 25th. — The cold, with its accompaniments, sneezing, dull confusion in head, &c., continued. At about 11 a.m. transient drawing in index finger. In 2 h. subsequently a similar drawing in 1. sup. maxillary bone. At 8 p.ra. troublesome drawing in I. side of hypogastrium (for 2 m,), which spot was also painful to touch. 26th, — The catarrh is still present, only somewhat diminished in degree. In forenoon, sudden drawing in 1. thumb and r. little finger (immediately disappearing on movement and is quickly returning in rest). At about 10 a.m. drawing in hypogastrium on 1, side, and tenderness on pressure. At about 2 p.m. troublesome clawing in sternum, frequent short dry cough and increased discharge of urine. Frequent waking at n. ; towards m. a pollution. 27th. — On rising, drawing in r. thumb; at 10 a.m. drawing and pressing in hypogastrium on 1. side, particularly when touching it ; during d^ drawing, now here, now there, and frequent hacking cough ; p.m., drawing in r. arm and forearm ; towards e. painful drawing in r. great toe ; at 6 p.m. pressing in middle of sternum. 28ch. — Perfect health. 29th. — Immediately after dose, drawing in lower incisors ; about II, drawing in r. thumb ; at 5 p.m. drawing in I. sup. maxillary bone; in e. feeling of roughness in throat, and frequent short dry cough. 30th. — In forenoon, drawing in r. sup. maxillary bone, in inner side of I. forearm, and In fingers of r. hand ; feeling of roughness in throat, and frequent dry hacking cough. The catarrh, which had vanished, shou-ed itself anew by an increased secretion of mucus from nose. Copious urine. 31st. — Increased urination; catarrh worse. Nov. 1st. — In m. a loose stool, and after it a troublesome pressing in anus, which rc> mained whole d. Catarrh became very severe, and one or the other

nostril was almost constantly obstructed. At 3 p.m., sneezing, succeeded by very violent sticking in lower part of r. lung, which lasted until II p.m., when, although very severe before, it disappeared at once. This sticking was greatly aggravated by sneezing, deep breathing, and coughing (but not by movement). Pain, as if parts were sore, in region of ribs on touching them. At 4 p.m. drawing in fingers of r. hand, and afterwards in r. elbow. 2nd. — Drawing in r. calf whole d. Catarrh reduced to a minimum. At .4 p.m. a hard scanty stool, and pressing and itching in anus for almost whole e. Jfd. — The running from nose is again pretty copious ; frequent sneezing ; at about 4 p.m. sneezing, and then some painful stitches in side *>f chest, within. 4th. — At 6 a.m. very severe stitches in lower part ^ r. chest ; about 5 p.m., drawing tearing in r. knee.

h. Dec. From 7th to 14th W. took every d. at about 9 a.m. a table-spoonful of the tinct. Effects : 7th. — A pollution in n., and after, a troublesome burning in urethra. 9th. — Want of appetite, especially in e. On loth a pollution in n. nth. — Feeling of roughness in throat, which soon went off; then for i h. feeling in throat as if there were a painless tumour there. At 4 p.m. a papescent stool, and transient drawings often flitted about, now here, now there, especially in upper part of thigh. Urine increased. 12th. — Pressing in 1. breast, as if towards lower lobes of lung, especially when breathing deeply ; frequent urination ; no evacuation. 13th. — Chills, even in warm room ; in e. felt well } no evacuation. 14th. — On waking in m. drawing in 1. side c^neck ', then drawing in upper part of 1. thigh (lasting 2 m, and rendering walking painful). Two stools followed, one hard and unsatisfactory, afterwards another, papescent, which left behind a long continuing burning in anus. 15th. — In forenoon 3 papescent stoob (at 6, 9, and 11). Dinner nauseated him. Chills even in warm room, and apprehension of becoming ill. At 6 p.m. these symptoms vanished, and the feeling of health was restored. i6th. — Sudden drawing here and there, especially in fingers of r. hand ; no evacuation j at 4 a.m. a pollution. 17th. — Sudden drawing in limbs. i8th. — In m. a hard unsatisfoctory evacuation ; drawing in limbs. At i, feeling of dryness and sense of constriction in throat. It was the same sensation that is perceived when one is for a long time exposed to heat of sun without drinking. In n. a pollution. 19th. — After rising, burning in external canthi and in urethra. Drawing pain in inner side of 1. forearm during whole forenoon, particularly when arm was at rest. The feeling of dryness and constriction in throat appeared again in a slight degree. Drawing in inner side of 1. upper thigh, in r. knee and r. hip. At 6 p.m. a very unsatisfactory stool after much straining. 20th.— Feeling as if eyelids were swollen and a foreign body were in eye ; drawing now here, now there, in extremities ; in e. pressing towards back in chest, with oppressed breathing; no stool. 21st. — In forenoon an unsatisfactory stool ; drawing in extremities, especially on inner surface of upper part of 1. thigh and forearm (only while at rest). 22nd.— P.m., another unsatisfactory stool ; drawing in different parts of extremities, not lasting long, but frequently quite troublesome.

c, 1845, Jan. — After a pause of 5 weeks, W. on 27th, 29th, and

30th, took each d., about 6 p.m., 2 table-spoonfuls of lath dil.of Thuji, and on lOth Feb., at about 5 p.m., he took 3''j of same dil. The dil$. were prepared with distilled water. 30th. — He first perceived, soon after taking drug, feeling of dryness in throat, lasting 2 h. ; in e., drawing in r. thumb and forearm, then in 1. thumb and in upper teeth of r. jaw. The increased secretion of mucus obliged him frequently to blow his nose. 31st, — In m., frequent sneezing, stoppage of r. nostril, alternating with running. This catarrh lasted 2 h., then suddenly vanished ; it appeared again for a little while in e.,andccaie(l suddenly as if cut off. Feb. 1st. — The same symptoms. lOth.— Immediately after dose, feeling of dryness in throat, which lasted all d. Ilth. — Feeling of dryness in throat whole e. ; pressing in I, side of chest, particularly troublesome in region of ribs; several times, drnring in lower incisors, and in ist joint of r. index finger; violent itching in lower part of sacral region ; at n., sticking from r, velum palati Into internal ear ; secretion from Schneiderian membrane increa»ed. 27th. — As a closing experiment, W. drank Jiij of 30th dil. (prcparni with distilled water) at a draught. This was at about 5 p.m. ; he perceived no result whatever.

Dr. F. Zeiner, 42 years old, of delicate constitution and phlegmatico-sanguineous temperament, healthy from childhood (except the usual diseases of that period), for the last two years frequently troubled with hasmorrhoidal affections, instituted four experiments upon himself with Thuja. (It was his first essay with drugs.)

a. 1844, Nov. 7th. — Without making any alteration in his ordinary mode of life, Z. took, at 9 a.m. (2 h. after cafg au lait), I dr. of the tinct. in water. Immediately after dose he experienced vertigo, soon disappearing, scraping in throat, slight griping above navel, sticking in r. temple, numbness of 1. foot, and feeling of weakness in it in walking up and down room ; feeling of coldness over whole body, i h. after, the griping drew from umbilical region towards r. groin, and occasioned there transient, often-returning pressing. The vertigo, scrap* ing in throat, and lame feeling in 1. foot still continued. 2 h. after having taken dose the vertigo and griping in abdomen disappeared in open air, but single stitches were repeatedly felt in r. groin and between sacrum and anus. Frequent urination in course of d. At 6 p.m., inflation of abdomen for i h., which disappeared by eructations. I h. afterwfards (10 h. after taking drug) single stitches were perceived in anus, alternating with burning in prepuce. At about 9 p.m., the prover*s odour was exceedingly, almost intolerably, increased, so as to become perceptible to those about him. The night's rest was good ; but soon after waking the stitches in anus came on, and the biting in prepuce also was troublesome for I h. 8th. — At 9 a.m. Z. took another dr. in water ; some m. after, griping above navel, and during ist h. single stitches in r. frontal eminence, scraping in chest forcing him to cough, quivering in upper eyelid, pressing pain in r. side of forehead, biting on upper surface of glans and io prepuce, feeling of weariness in 1. leg when seated. At 10 a,n>. another dr. Soon after, he felt shivering in back ; the feeling of weariness in 1. leg, the sticking in r. side of forehead, and the griping

h ibdomcn continued. Towards ii, drawing in 1. testicle and (re-

<\uent eructations of wind. At z p.m. (4 h, after dose) the itching on

prepuce became almost intolerable. Z. also observed during d. fre-

i^uent urgency to urinate, with passage of copious urine. Stools regular

on both d. 9th. — At 9 a.m. Z. took 4 dr. on sugary soon after,

;ht vertigo, griping about navel, itchings on prepuce, scraping in

hea, obliging him to cough ; with quivering of r. upper eyelid,

baniing in I. eye near internal canthus, compelling him to rub it, weak-

ness of eyes, single fine stitches in temples, feeling of weakness in 1.

leg when seated, pressing in small of back. At 2 p.m. increased

»<c:etion of sweet saliva (lasting 5 h.), drawing in 1. testicle, urgency

to urinate^ with copious urine, swelling of cervical glands, pains in

sacrum. On following d., on which nothing was taken, he felt in

forenoon the pains in sacrum, quivering in r. eyelid, and feeling of

•wfcikness in 1. leg; in e., burning in orifice of urethra and frequent

Hiitchcs in anus, i rth, — 8 dr. of tinct. Soon after taking dose,, quiver- Bg again in r. upper eyelid, feeling of coldness with numbness of 1. iw, solitary stitches in shoulders, and frequent chills over whole body. A 3 p.m. a general chill ; drawing in I. testicle, in 1. thumb, in occiput ; sticking in temples, in r. side of forehead, and in 1. knee ; pressing in sacral region. 12th. — Z, took nothing. In e., sticking "ow in 1. knee, now in head, and now in elbow and finger-joints; then general debility, with such weakness in legs that he thought he should fall. On following d. he observed a red spot on inner surface of prepuce, which itched violently and disappeared after 24 h.

b. Nov. 25th. — After omitting drug for 14 d., Z. commenced again at 9 a.m. by taking 4 dr. of 3rd dil. on sugar. Soon after, he perceived griping about navel, itching on r. knee, on 1. shoulder, Scrotum, and divers other places, and burning on inner surface of prepuce. After 1 h. violent drawing in testicles; vertigo; greatly increased secretion of saliva (of metallic taste), lasting 2 h., with swelling of salivary glands. At 4 — 5 p.m., sticking pains in glands of groin. During whole d. slight chills in warm room ; increased urgency to urinate. 27th. — At 9 a.m., 8 dr. of 3rd. After ^ h., itchings on prepuce, griping about navel, sticking in 1. side of forehead, pressure on f. shoulder ; weakness of eyes, particularly observable when writing.

hct l\ h., renewed increase of saliva (of acid taste) during 2 h.;

icking in anus and violent stitches in 1. side of chest, which frequently urned throughout d, ; continual slight chills and increased secretion urine. 28th. — The symptoms of preceding d. were repeated after ing 12 dr. of same dil.

c. Dec. 17. — Z. ceased taking drug for 18 d., and commenced n by caking 15 dr. of the undiluted tinct., whereupon, in course of h€ observed following symptoms : Pressing in forehead, frequent

itches in frontal eminences, sticking, at one time in r., at another in ' side of chest, griping about navel ; scraping in throat, intolerable biting in anus, drawing in 1. testicle, obscuration of eyes while writing. i8tb. — 20 dr. Soon after dose: staggering while walking in air; pressing in middle of forehead; sticking in both frontal eminences (lasting whole d. and continually increasing) ; general debility and

weakness in legs ; sticking in shoulders and in r. knee ; stitche region of groins, often repeated during d., with feeling as if inguinal glands were swollen ; intolerable itching in anus, lasting almost entire d. ; hasty urgency to urinate, with copious urine. 19th. — No medicine. On awaking, sticking pain in I. frontal eminence, as well as violent pressing between shoulders, which feeling had entirely disappeared 8 d. before ; frequent twitching in middle finger of r. hand. The itching in anus appeared but seldom. 20th. — After 35 dr., dull confusion in head, weakness in legs when walking j stitching in forehead and in different parts of body, especially in shoulders, arms, and legs; in e., spitting of much saliva. The itching in anus is almost gone, tongue and palate are very sore. On the following 3 d. no dose. list. — On awaking, sticking in 1. shoulder, and in course of d. flying stitches in glans ; there was also an increased secretion of saliva. 22ttd and 23rd. — The whole of the symptoms gradually disappeared, tai prover no longer perceived the troublesome itching in the anus which had so much annoyed him during whole continuance of experiment,* 24th. — Z. took 30 dr. During the two succeeding h. burning and itching in anus, griping about navel, painful constriction in hypogaS' trium, weakness in legs, cracking in knec-jomts, drawing in r. groin, and pressing in renal region. At 6 p.m. pressing in forehead^ sticking in 1. frontal eminence, acid taste with increased secretion of saliva, swelling of one of the cervical glands.

d, 184.4, Jan. 4th. — After having rested 10 d., Z. took 10 dr. of I2th dil. During first 2 h. he observed during rest: transient griping about navel, repeated stitches about anus, which continued to increaie in violence during d,, eructations of wind, sticking in I. side of chest, on I. scapula and r. temple, failure of eyes when reading, transitory chill over whole body with cold hands in a heated room, pressinj

one time in r., at another in 1. arm, drawing in fingers, pain in na[

neck, stitches in 1. side of forehead, numbness of I. foot while sitting, crawling in toes, extraordinary weakness in 1. leg when going <M, slight reeling, pains in small of back, and increased secretion ofsalinu At 4 p.m. drawing in 1. testicle with feeling of weight in it, ur| to urinate with copious passing of water. During the 3 follow! no medicine being taken, frequent pressing in forehead, sticking in frontal eminences and temples, pressing between shoulders. 8th.— 15 dr. of 1 2th. During first 2 h. pressing and sticking in forehead, sticking in shoulders, stitches in anus, numbness of 1. leg, drawing in 1. testicle, feeling in testicles as if they moved, drawing in fingers and pressing in 1. upper arm. All these symptoms disappeared while walking in the open air. 9th. — No dose. Frequent itching on glan* and prepuce, alternating with stitches in anus, and the urgency to urinate was frequent and hasty. I2th. — The proving was concluded by taking 25 dr. Thereupon he observed pressing in middle of forehead, sticking pain in r. axilla, increased salivary secretion, which lasted all d.f stitches in inguinal glands, itching in anus, flying stitches io

In my case this itching in the aniu was the most durable symptom, and 1 pearcd only after the lapse of several weeks. — Mayrftaftr.

weakness of eyes when readings pressing between shoulders and ^vUng in toes of I. foot, which were painful in treading. In after- "mi, while seated, feeling of lameness in 1. leg. At 7 p.m,, when Iking, uncommonly violent stitch between coccyx and anus. 13th. »A(tcr waking, sticking in 1. side of chest, lasting all d. On disitinuing drug, all abnormal manifestations disappeared. Dr. Zeiner accompanies his beautiful and instructive proving with remark, that during its whole period the sexual desire was cometcly asleep; and he further made the observation, in accordance with : experience of other provers, that the greater part of the drug-symoms were most clearly developed during rest. {Ibid.) 19, The boldest and most indefatigable prover of Thuja was Prof. Zlatarovich, who tookj in 155 d., 42,260 dr. of tinct. in large

a. 1844, Sept. 6th. — Z. began his proving with 6 dr. of tinct., which, as also the succeeding doses, he took in the m. fasting. On 3 following d. he took 8, 10, 12 dr., and experienced no effect. lOth, after taking 14 dr., he first perceived, in e., a transient pain I vertex, as though bone were repeatedly pierced with a needle near l^inal suture, nth. — No effect after 16 dr. 12th. — After 18 dr., e., pressing and burning in haemorrhoidal vessels and frequent olent sneezingj which returned on m. of 13th after 20 dr. From fth Sept. to 5ih Oct. Z. increased dose daily by 2 dr., and observed following results: Sept. 14th. — After dinner, frequent violent ftneeting without catarrh (a thing very unusual with himj. 15th. — In m., several times, short, dry, barking cough. i6th. — In afternoon and t, pressing in a small spot under sternum, which gradually extended to scrobiculus. 17th. — At n., and on waking, several times short, interrupted, convulsive cough, excited by an irritation in larynx, and leaving an unpleasant dryness in it. At noon, moderate appetite^ head somewhat confused, especially in forehead, throat dry and rough, and some difficulty in swallowing. In e, he felt very weak and unwell, with heaviness and tension in legs, so that walking was painful ; head '^^■J in that part of anterior half which was covered with hair, as :h compressed; nevertheless a very good n. succeeded. i8th, — U( ihc catarrhal symptoms, nothing is left except a little roughness in throat. This also disappeared by noon, and he felt well again. Until this point in the experiment the sexual impulse had been much wired. 19th. — A good night's rest was followed by a d. destitute of fiptoms. 20th. — On rising, inconsiderable cough and roughness in l^rott, disappearing by noon. In its place appeared troublesome dryland sensitiveness of nose, as at commencement of catarrh. This *cn$jtion extended by degrees into frontal sinuses, and eyes also became seniitive. These catarrhal symptoms disappeared again during afternoon. At commencement of dinner a jerking constrictive pain was felt hairy portion of head, and in afternoon painful tension in r. popliteal "ce. 21st. — In forenoon dull confusion of head; slight burning in Qnuch, and in 1. external canthus. At 2 p.m., violent burning in eyes and eyelids ; frequent sneezing. Roots of hair of 1. eyebrow are sensitive when passing hand over them. At dinner, burning tear-

ing in whole 1. side of the face, apparently in periosteum. After dinner, general uneasiness for 2 h. In e. burning pressing pains in I. eye, on whole upper surface of globe, aggravated by touch ; sensitiveness of I. temple; slight drawing in nape, and repeated sticking from nape to r. ear and axilla. After supper, dull confusion in head for as h. On lying down, r. leg was so painful that he was obliged to pbce himself on 1. side, contrary to his usual habit, and so to lie duri;)^ whole n. For several d. the sicin on vertex has been sensitive to touch, and shines so clearly through the hair that the proven was afraid he was becoming bald. 22nd, — On awaking, some headache in for^ head ; after rising, same feeling in 1. nostril and r. frontal sinus came on that had been experienced 2 d. before j but now r. nostril wit entirely free from it. At noon, frequent blowing of thick mucus from nose. Whole r. leg was painful. Repeated urgency to urinate, even when there was but little water in bladder. In e., all morbid symptoms had vanished, except that a little spot upon the vertex itilL remained sensitive to the touch, 23rd. — No symptoms ; two liquA $tools which were evacuated soon after taking the dose seem to hire: prevented their appearance. 24th. — He had no other syraptooisa to-day than slight burning in haemorrhoidal vessels, and copious secrc — tion of mucus from nose. 25th. — In m., oppression in head, especiiH in region of forehead and temples, which an h. after began to incros-* and extended over vertex, but subsequently entirely disappeared ; sligl» burning in canthi. After dinner, general weariness with slight ha(M. ache in forehead. In e., tension in extensor muscles of cxtrerait)^ and trunk, now here, now there ; subsequently heat. 26th. — Nornu^' feelings during d. In e., drawing and sensation of weariness »*> limbs, especially in upper arm, and forearm near wrist ; oppressio" in the head, especially in forehead. Intellectual exertion soon fatigues ; tobacco smoke is not as agreeable as at other times; frequent yawning- 27th. — P.m., slight dulness in head ; no other symptom. 28th,-- In n., frequent cough with raising of thick mucus. After dinner, general uneasiness, restlessness, swelling of abdomen, feeling as if beaten in upper arms. In e.,good health. The cough ceased in d. agth.— On awaking, glans is very sensitive, drawing back prepuce causes pain; frequent dry hacking cough. Soon after dose, general uneasiness iwi stretching of limbs. In e., frequent violent sneezing and tickling '» the nose. 30th. — In m. frequent sneezing again, with increased secretion of mucus, accompanied by frequent dry hacking cough. Oct, i St.— During d., frequent dry hacking cough ; in forenoon, when walkingj some itching in hieraorrhoidal vessels ; after dinner, strong inflation « abdomen, 2nd. — In forenoon, violent itching and pressing in the haemorrhoids. 3rd. — In forenoon, on upper lip, an elevated, red, violently itching spot, which compelled him to scratch, but was gone without a trace at expiration of an h. 4th. — In m., frequent viicnt sneezing, which in a short time ends with dulness of head ; aftef dinner, extraordinary distension of the abdomen, which seriously embairassed respiration. 5th. — No symptoms after taking 64 dr. 6th.— 70 dr. At night, much flatulence was discharged. In m., sneezing! burning in skin of r. lower leg. After breakfast, frequent eructatioot

with the taste of Thuja ; frequent short, dry, interrupted cough j slight chill. In e., sudden, cramp-like twitching of under lip, and here and there in circumscribed spots on skin. From the 7th to the last of Oct. c increased dose daily by 5 dr., so that on the hrst day he took 75, id on the last 195 dr. The following were the results : 7th. — No Symptoms. 8th. — An h. after dose, squeezing in the hemorrhoids. qth. — No symptoms. loth, — Discharge of bloudy slime from anus, as well by d. as at n. ; frequent discharges of flatulence, which were ilways accompanied by some moisture. Towards e., uncommonly strong appetite, which must be appeased ; subsequently, pressing in the haemorrhoids when seated. nth. — No symptom worthy of mention appeared during whole d., but in e., after much conversation m company, a pressing headache began in forehead, extended gradually towards the vertex, and slowly disappeared. 12th. — 100 dr. Slight dnwing behind r. ear, and some constriction in ear ; ache in forehead, which, after an h., merged in sensation as if a wedge were driven into temple. Sneezing did not aggravate headache, but motion of head and Willowing had that effect. At same time, cheerful disposition and inclination to intellectual exertion. In n. very good sleep. 13th. — Uncommonly comfortable and easy, 14th. — In m., transitory burning in anus. At noon, tension in whole r. leg while walking. After dinner, slight sensitiveness in skin under hair on forehead, where the fool air at the open window was exclusively felt. 15th. — At noon, '^'equent violent sneezing. i6th and 17th. — No symptoms. i8th. — °-m., burning and pressing in stomach, lasting several h. jgth. — Several small, painless tubercles appeared upon head. The hair comes off on the vertex. 20th. — In m., raising of tough mucus ; in forenoon, "ching in perinxum when seated ; slight drawing over 1, eyebrow. 2 1st. — At noon, great dulncss of head ; drawing in both thighs. In ^•> pressing in forehead and in r. temple. 22nd. — On waking, ache in "forehead, which disappeared again after 4 h. After a normal evacua- <on, burning and drawing in of anus. At noon, drawing in lumbar ^nusclcs while walking. 23rd. — At noon, drawing again in loins. Lumbar vertebrs are somewhat painful when leaning forward in sitting ; feeling of soreness in perineum. 24th. — No symptom during whole 25th. — In m,, on rising, drawing from loins towards nates. After inner, very violent itching in anus. 26th. — At n., increased secretion ol mucus in larynx and trachea. 27th. — Slight pressure in the hsemorfhoids i in e., slight drawing in 1. upper arm. 28th. — Drawing, now here, now there, but worst on 1. side of body ; burning in external Cinthi. 2gth. — In m., slight heat and redness, with burning, on upper I'pj drawing in 1. arm. 30th. — On awaking, frequent violent sneez- 'og with tickling in nose and burning in eyes, as though a catarrh were coming on i drawing in r. forearm. 3JSt. — In forenoon, itching and burning in hemorrhoidal vessels when walking ; internal shuddering and 'celing of cold whole afternoon, with dull confusion in head. In sulcus tcr nates, clammy moisture is secreted, Nov. l st. — Dose was omitted ; [nwing in limbs, particularly in r. forearm, aggravated by movement of >i&b; coldness in hands and feet; drawing in whole r. leg -, pressing in tide of chest. 2nd. — 200 dr. In m., roughness in throat with con>

tinual inclination to hawk, and with deeper tone of voice, which disappeared again after breakfast. At noon, burning and feeling of sorcnc« in anus. 3rd. — 205 dr. In forenoon, drawing in r. elbow-joint, ai squeezing in haemorrhoidal vessels. 4th. — No dose. At noon, viola itching and squeezing in haemorrhoids ; tension in the extensors ofr. arm when writing. P.m., normal state. In e. renewal of violent squeezing and pressing in anus ; very earnest frame of mind, in $pit( of the cheerfulness of those around him ; a small suppurating boil on back. 5th. — 210 dr. At noon, drawing in r. lower leg, especially 00 outside towards anklr, and in r. hand, particularly in thumb. From 4 to 6 p.m. severe burning and pressing in stomach. 6th, — 210 dr. A.m., burning in the stomach for an h. At noon, flying stitches on r. side near sternum for ^ h. These stitches had the peculiarity that instead of being aggravated they disappeared on taking % d inspiration, and returned again only on the succeeding expiration. In addition, slight tension in extensors of r. hand, and drawing, in dorsum of r. ring finger. 7th. — 225 dr. ; and he daily increased dose by 5 dr. until i6th Nov., when he took 270 dr. In m., discharge of copious, inodorous flatulence, and hard unsatisfactory stool ; tension in bend of r. elbow when writing. 8th. — In forenoon, pressing and burning in stomach for an h. At noon he perceived a sensation as if lower part of thorax were surrounded with a bandage, which sensation disappeared p.m. In e., very disagreeable pressing in region of heart, confined to a small spot. 9th. — Immediately after dose, r ' and rumbling in intestines; afterwards, frequent dry hacking c^i^ tension in r. hand, especially in thumb ; the same in outside of r. thigh, extending into knee, particularly when walking and bending. In forenoon, r. knee-joint was painful when seated, but pain soon disappeared, and was succeeded by feeling of cold in knee. A transitory pressing and tension in heart then came on, and on its ceasing, the coldness in knee was again perceived, but in less degree. All these symptoms were gone at noon. At 1.30, on closing eyes, a feeling of vertigo. The power of thought was increased, but rather for analytical than synthetical reasoning. loth. — In \ h. after dose, rumbling in intestines, with slight griping j frequent coughing up of mucus, i ith. — In m. roughness in throat, and frequent hacking cough. Upper lip sonaewhat swollen, and burns. After a loose stool, burning in anus. After dinner, dull confusion of head ; afterwards heartburn. These symptoms disappeared in open air. In e. slight burning in eyes. 1 2th. — In m. he felt well. At noon, dull confusion of head ; burning and dryn in r. nostril, up as high as frontal sinuses ; slight burning in r. eyi oppression in lower part of thorax ; frequent, short, dry, hacking cough He feels much better in open air than in room ; the indefinite feeling of uneasiness, however, cannot be exactly described. In e. knees were painful while walking, as though bruised ; weight of body seems to him to be too great for legs. 13th. — At n. he urinated more than usual. In m., after rising, frequent raising of mucus, leaving behind feeling of sensitiveness in larynx j discharge of copious inodorous flatulence. After dinner, drawing behind r. ear, with single stitches in mastoid process of temporal bone. When this symptom had disappeared, as it soon

-1^1

Aid, short accesses of crawling and creeping on 1. side of occipital bone came on j also, burning and pressing in both eyes. 14th, — On waking, *ching in forehead, which disappeared by degrees after rising, but returned at about 9.30, became heavy and pressing, and only vanished after 4 h., after which, pressure on vertex, as if a weight lay there. To ihtse were added, weariness and uneasiness in whole body, coolness and tying shudderings over back. At noon his food had a disagreeable bitter-sharp after-taste, which was salt, especially at root of tongue ind in fauces. The uneasiness became less after dinner, but even black cofFee left behind an unpleasant after-taste. 15th. — Soon after dose, constriction about navel and slight pressing in lower border of r. orbit, soon going off; but orbital edge remained sensitive to touch and to closing of eye for J h. Afterwards, tension in r. anUe while walking. Respiration is not altogether free j thorax ii raised during inspiration with somewhat more difficulty than usual, and a short, dry hacking cough frequently comes on ; a violently Itching tubercle makes its appearance upon upper lip, near r. corner of mouth, 1 6th. — An h. after dose, oppression of chest, troublesome btnthing, drawing between shoulders, burning and pressing in stomach increased by movement and by speaking. Constriction of anus after no ppescent stools. Also heaviness and lameness in r. arm, and dighc drawing in r. masscter, with confluence of saliva in mouth. From the i ~th to the 29th he ceased to take the T'huja, and observed the following symptoms : 17th. — In n., drawing in r. upper arm, axilla, and shoulder, preventing his lying on that side. In m. these pains heamc intolerable, but by warmly wrapping up painful parts, they gradually diminished, and finally entirely disappeared, leaving behind feeling of lameness in arm. At about 9.30, tearing in shoulders and upper arm returned in frequent short attacks. After dinner, general wariness and universal feeling of discomfort. In e. he feels generally better, but pain in shoulder is again very violent, and in r. arm, especially in forearm, there is a condition bordering upon paralysis, with feeling of coldness. Before going to sleep, very gloomy frame of mind. '8th. — At 10 a.m. pain in arm came on in short accesses, was sensibly felt until noon, but was milder than the d. before, and ceased entirely p.m. Mind became more cheerful again. 19th. — The pain in arm is entirely gone, and Z. felt well all d. 20th. — At noon, ♦light drawing in sacrum, drawing in L groin, and frequently dry hacking cough. No trace of pain in arm. 21st. — Burning in whole nose, ■which seems to feel as if swollen, with increased sensitiveness on Jcpiuin, on which several vesicles are to be seen. Upper lip is likewise Jciuilivc. P.m. these symptoms have disappeared again, and vesicles wa nose are dried up. On the two following d. no drug symptoms were observed. 24th. — In e. of 24ch and whole forenoon of 25th an exceedingly troublesome headache came un, which wjs seated in upper »urface ot the vertex, was heavy and pressing, and from time to time came in smgle stitches and thrusts. Brain was apparently unaffected, but head externally was somewhat sensitive to touch, as were also eyes. Cool air diminished the pain ; when it was at the worst he supported bis face in the concavity of his hand, and for some time rubbed his VOL. tv. 23

forehead, eyes and face, whereupon the pain entirely disappeared, anfl in e. his head was wholly free, except a slight crawling and creeping on the places before indicated. On the 4 following d., no symptomi

b. Nov. 30th. — 300 dr. of tinct. Two h. after, slight teann* in ^ nape, and distension of abdomen by flatulence. Dec. ist.— Ko medicine. In m. he remarked on forehead over root of nose a red streak, which did not itch or present any appearance of roughncj>, Mwi was visible until noon. He had feeling over crest of r. ilium, on touching it, as if it had been bruised. At noon, transient drawing came on in first joint of r. thumb, which was, in consequence, somewhat less easily moved. 2nd. — 300 dr. In forenoon the red 5tr«k was again visible on forehead, but no other special symptom manifested itself the whole d. 3rd and 4th.— 300 and 310 dr. produced no effect. 5th. — 320 dr. There appeared in sulcus between nates, not far from anus, a painful spot, which felt sore for an h. 6th. — No drug and no symptoms. 7th. — 330 dr. Immediately after dose, flying stitches in different parts of body ; frequent dry hacking cough ; afterwards, raising of mucus; p.m., pressing and burning in stomach for an h. ; then transient feeling of pressure in heart and single stitches in lower half of r. side of chest. (Not the slightest trace is perceptible of the hxmorrhoidal congestion, which was usual during the earlier days the experiment, and this the prover considers as a curative effect of drug.) 8th. — Nodose and no symptoms, 9th, — 340 dr. P.m., sli burning and pressing in stomach during an h. In e. general wearini and uneasiness, with dull confusion of head ; drawing in joints of han and feet. The abdomen was incommoded by a supper which was eaten with appetite. loth and lith. — 350 and 370 dr. produced no symptoms. 1 2th. — 380 dr. In m., a small, painless, non-itching tubercle near raphe of the perinajum ; eyes on waking were glued with mucus. P.m., relaxation and sleepiness. In e., inclination for work ; frequent slight drawing from mastoid process of r. temporal bone down> wards. Afterwards single, flying, very painful stitches from depth of r. ear through external ear. An h. after, when earache had disappeared, a violent stitch drove suddenly through 1. temple as if an awl had been forcibly thrust into the brain. The pain lasted but a few seconds, but the spot remained for some time sensitive. 13th. — 400 dr. In m., feeling of fulness with stoppage in r. ear without pain, and frequent sneezing, which returned in c., soon after which pretty violent itchi in both nostrils towards point of the nose, after a short continuance which a secretion of a thin mucus followed. Also sticking dra ing on inner surface of 1. forearm towards wrist ; nausea mounting from abdomen, with slight inclination to vomit. (Z. makes the observation that the morbid feelings produced by Thuja are aggravated during rest ; and by remaining quiet, symptoms arc developed which disappear on motion in the open air.) 14th. — No dose and no further symptoms except tension in flexor surface of r. leg and inflation of abdomen^j 15th. — 410 dr. P.m., a couple of transient tearings in tendinous e|^| pansion on r. side of neck. 16th. — 420 dr. During whole foreno^^^ a very unpleasant sensation of cold, the external temperature being + I K. (34® F.). Hands and feet are icy cold, and skin of hands is

lent I

3SS

purple. At noon, before dinner, for a little while oppression of chest with difficult respiration and slight pain in anterior surface of stomach on taking a deep inspiration, as though from external pressure. In ifternoon and c. these symptoms were gone. 17th. — No drug and no symptoms. i8th. — 430 dr. Soon after dose tenesmus and a hard, my unsatisfactory stool ; also transitory pressure on chest ; burning in urethra towards the bulbus for several m. ; in e. some headache ; at n. quiet sleep, igth. — No dose. On awaking, violent pressing headache m vertex, which went off by degrees while he was still in bed, and ^iiappeared entirely after he had arisen. Breakfast did not relish ; hile at table, slight vomiturition ; to which were added general wanness and faintness, with pressure and sensitiveness in eyes. 20th. —450 dr. Not a trace of a symptom appeared in foreaoon ; even the (nictations with the taste of Thuja, which formerly were sure to come Mon after taking the drug, did not once manifest themselves. In ifternoon, general malaise, with sensation as if a chill were about to come on. Dull confusion of head for ^ h. 21st. — No dose. In m., burning in skin of r. lower leg ; slight sensitiveness in vertex and r. eycj feeling of soreness at anus. Towards noon, throbbings in r. temple when rising from a seat. Dinner was devoured with a veriable canine appetite. Two h. afterwards, general malaise, frequent dry lucking cough, and slight dulness of head. In e., pressure in hemorrhoidal vessels when sitting. A painful inflamed tubercle makes its appearance on r. side of forehead, and neck feels as if swelled, so that the loose neckcloth is troublesome. Serenity of mind. 22nd.^ Nodose and no symptoms. 23rd. — 500 dr. In m. before dose, short ^ry troublesome cough, without the former catarrhal symptoms. After it had gradually become quieted by taking sugar moistened with water, [violent burning in stomach came on, which lasted until he got up. In forenoon, uneasiness and sensitiveness to cold air ; at noon, troublesome ■Irawing in r. radius along forearm, as well as in hand into little Hnger. In afternoon, heartburn. 24th, — In afternoon, when passing water,slight l>uniing in urethra. 25th. — In m., on waking, he had a violent erection, with strong desire for coition ; but notwithstanding the existing voluptuous feeling, there was no emission, which does not usually fail with hinj. He felt, besides, weight and tension in r. leg, and in e. burning in eyes, especially in internal canthi. On 26th he felt perfectly well, and 10 on the 27th again took 500 dr. On awaking (before the dose), the fexual impulse was again active, and on this occasion with normal results. After dose, in forenoon, violent tension in r. lower leg, on which skin was painful as though sore and ulcerated, which sensa an wu lessened after dinner. In the afternoon again a very violent )ru Afterwards, a delightful feeling of corporeal well-being and bclination to intellectual labour. In e. his leg was entirely without », and a short, dry, interrupted cough was excited by tobacco smoke. '18th. — 500 dr. again. In forenoon, when walking in open air, slight transient colic. As he came in at n. from the cold air into a room he felt a very violent stitch in r. ear, from external part inwards to internal, which compelled him to hold his breath, and left ear sensitive tot a while. 29th. — Nodose. In m. another but less severe attack of

the pain in ear came on. He had a sensation in ear as if free acctfl

of air were prevented, but without the slightest diminution of heiring

In forenoon ear was well again ; but after dinner he had the feeling t

it as if the external organ were filled with water, similar to the tensi

lion felt when one dips his head under water. Drawing and td

sion in occiput. R. lower leg was twice painful during d. 30ih.-

500 dr. Immcdiatclv after rising, the pain in r. lower leg again est

blished itself. A spot next to the tibia, near a varicose diUiatio

smarted as though it was sore, was very sensitive to touch, and sk

over it was slightly reddened. In forenoon burning and pressing

stomach. At noon but little appetite. P.m., strong inflation of a!

men i burning in stomach ; dry, short, hacking cough, and pecvi

humour. In e. r. lower leg was again painful upon its upper surfai

as if sore. 31st. — No dose. On rising, after a very good night's n

the pain in leg again made its appearance. The spot noticed yestei

is still sensitive, but not more reddened. The ear, which for somedi

has not felt altogether right, is now entirely recovered. In aftcrnoc

heartburn. In e. he felt well. 1845, Jan. Jst. — After a good nigh

sleep he awoke with a very severe pressing headache, which,

commencement, was confined to vertex, after a while extenil

to frontal eminences and eyes, and again returned to vertex and disl

peared. In m. he hawked up thick tenacious mucus from laryi

Although no Thuja had been taken, still the burning in r. lot

leg developed itself in forenoon, as did also, for a little while,

reminiscence of earache of 29th Dec. In afternoon, severe bul

ing on inner side of r. lower leg was again troublesome, In

head and ear were entirely relieved. But when he especially dire

his attention that way, head- and ear-ache threaten to come on aga

which is not the case when he intentionally fixes his mind upon ot|

suffering parts. 2nd. — 500 dr. In forenoon, frequent eructations

wind, preceded each time by painful constriction of stomach. Insn

of r., 1. ear has, to-day, a touch of the sticking pain. R. lower 1^

still sensitive in the spot upon tibia heretofore indicated. 3rd.

500 dr. Heavmess in r. leg, with burning on whole inner surface

lower leg. At 2 p.m., slight searching and griping about navel, Ifl

great drowsiness. 4th. — No dose. In m., after much strainina

very hard evacuation, followed by pain in anus. At same time 0

borygmus, and, 3 h, after, a couple of liquid stools, with subseqa

burning in anus (for over an h.). Pressing and burning in stomach, 1

after dinner. R. leg is less painful than yesterday. Several infian

tubercles are visible on face. 5th. — 500 dr. In m , frequent ha*

ing up of thick mucus. The burning in r. lower leg is drawl

nearer to ankle. After breakfast a very unpleasant sweetish-salt tai

especially in back part of mouth and on root of tongue. At 10 aJ

pressing and burning in stomach for J h. ; afterwards repeated oot^

ing up of mucus. In e., heaviness and burning again in r. loi

leg. Hinges of under jaw crack when he yawns, a wholly unia

occurrence. In n., whole r. leg up to hip-joint was ptini

heavy, and less moveable. Pain was drawing and tensive. 6th.

500 dr., after which dose was omitted for 6 d. Sooa after the diti

burning in throat, obliging him to hawk; then slight raising of thick "tucus i frequent sneezing, with obstructed nose and roughness in throat. These catarrhal symptoms became more severe in e., and tre accompanied by aching in forehead, with weight and pressure in tyes, and were followed by a very restless n. 7th. — According to the 'Sport of his wife, he has slept very uneasily, has constantly rolled about in bed and moaned. On waking, his throat is entirely coated with phlegm, and after hawking, larynx and trachea are painful. Then, pneral malaise, both of body and mind ; head aches in forehead, eyes ''burn, nose is obstructed, and voice is hoarse. At noon he felt better when walking in open air, but when at rest aggravation again returned. ^ There was much flowing from nose, feet were cold, and the general jftcling of illness sent him to bed early in e. It was, however, a long tptac before he could get warm, and dulness of the head, frequent cough, stoppage of nose, and, in short, all the symptoms of a slight itarrhal fever set in. 8th. — This m. he felt very uneasy and weak, »nd Jay in bed until 10. Afterwards he felt better. At noon, "Z2,iiig in head, which feels dull, frequent dry cough, pressure in P^rriorrhoidal vessels ; for the rest, good appetite. After dinner, burn- "g >M stomach lasting until e., when a short, jerking, dry cough took place. Nevertheless he was incomparably better in e. than on cviousd. The febrile symptoms came on again at n., but ceased V'" midnight, whereupon quiet sleep succeeded, and towards m. per- P'ration broke out. 9th. — During n. burning in stontach. On ''lcing, frequent dry hacking cough, and somewhat deeper and '«"ser voice. At noon, buzzing and roaring in head, and feeling in **"emities as though they had been bruised. In c., troublesome dryin nose up into frontal sinuses. loth. — In n., grumbling and ■•^ tiling in intestines. In m., frequent coughing up of thick mucus, rising, burning in eyes. At noon, a great improvement over pre- **«^g d. ; at I p.m., while sitting, single, flying, very painful stitches ^r^us, as if from a fine needle. I'hese stitches returned from time ^>rnc, but not in so frequent a succession as at first. Troublesome '^ess in nose. After dinner, great inflation of abdomen, to which added roaring in head. On movement in open air these sym- 'ks disappeared, nth. — On awaking, frequent coughing up and ing from nose of thick mucus ; subsequently, return of the trouble- ^'^e dryness of nose with sensitiveness of eyes. At ii p.m., violent fcssure in hsemorrhoidai vessels. In e., the former catarrhal sym- ''^'^'^s returned, accompanied by sensitiveness of eyes and frequent dry ^"K- 1 2th. — No symptoms to-day, except frequent dry cough. l^^ . — 500 dr. In forenoon, squeezing and pressing at anus; in '■f '""oon he felt well. No cough came on, notwithstanding he smoked * spoke much. After supper, flying tearing in separate jerks from 'S'c of under jaw to os hyoides, pretty deep in integuments. 14th. — '^ ^<Ir. Again troublesome dryness in nose with tickling ; then grip- ?6 iTi intestines, burning in r. lower leg, and after a very well-relished .^*fast a bitter sharp-salt taste in the mouth, particularly about root **^rigue. In forenoon, dryness and pressure in nose and frontal imuses so increased, that he was very much incommoded by it in

3S8

his lecture. At noon a catarrhal flowing came on, and disappeared again entirely in an h. after. Soon after, pressure on root of nose and copious secretion of mucus returned. The pressure on root of noae afterwards drew off towards ears, where it produced tension in auditory passages and stoppage of ears. This symptom vanished again after some time, and in place of it transitory pressure in hzmorrhoidal vessels was perceived. After supper, pressing and burning with occa> sional painful constriction of stomach. 15th. — 500 dr. Immediatclr after dose dryness and tension in nose, with feeling as if whole mucous membrane were swollen ; the taste in mouth alluded to yesterday also appeared. These symptoms disappeared after an h. At 2 p.m. cmiv sion of scanty and exceedingly dark'Coloured urine, causing burning in urethra. i6th. — A mucous cough set in in m. ; no dose was taken, and with this exception no symptoms were perceived. 17th. — 500 dr. In m. frequent coughing up of thick mucus. At noon, while sitting quietly in room, the familiar troublesome dry feeling in nose appeared, which was much ameliorated in the open air, but returned, though less violently, on coming into house again. The nose Hrst became moist after he had smoked a cigar. He noticed, in addition, two painless» tubercles about size of a hemp-seed in sulcus between nates not far from anus. In e. he perceived some painful spots on head, at most the size of a penny. The pain seemed to be seated in the bone itself, hf 8th. — 550 dr. On awaking he felt his head all over, but could noc detect yesterday's sensitive spots ; the tubercles near the anus were also missing. In forenoon, frequent cough, with raising of thick mucus ; in afternoon and e. short dry cough. 19th. — 575 dr. Dit* charge of much loud inodorous flatulence, and frequent raising of thick mucus with slight cough. 20th. — 600 dr. In m. frequent violent sneezing, with cough and raising of mucus, and slight burning of eyes. He remarked, on accidentally touching raphe of |>erinzum, that on r. side it was sharply prominent, and felt thickened as if skin were ia> durated, without being in the least painful. Violent heartburn an h. after dinner, lasting two m., then lulling for several m.,then returning, and so coming on in frequent accesses. Through whole d. the nasal secretion was tolerably copious, and thick mucus was thrown ofF by frequent coughing. Pressure in stomach was occasioned by roast meat eaten in e. He also perceived, here and there, a slight drawing under skin in tendinous expansions, and on making certain movements with his head a creaking in cervical vertebrae. This symptom had already been frequently observed by the prover without any particular attention being paid to it, but to-day it was troublesome in a much greater degree. 21st. — No dose. He slept remarkably well during n. In m. he coughed up mucus once or twice. Towards noon a very nnpleasant pressing headache came on in vertex, which diminished p.m., and disappeared in e. At 6 p.m. slight burning in stomach and frequent coughing up of mucus. 22nd. — 600 dr. Thereafter frequciit slight coughing up of mucus. At noon, burning in lower border of r. nostril, which was sensitive to touch (for | h.). 23rd. — 6ao dr. During whole forenoon he could not get warm, and twice, while walking, spat blood, the origin of which he supposed to be in the

cavity of the mouth, but could not trace it with certainty. In afternoon burning and pressing in stomach (for an h.) ; in the air tearfulness of eyes. 24th. — 650 dr. In m. slight coughing up of mucus; otherwise he felt well all forenoon. Afterwards, in the room, a watery catarrhal flow came on, and, after dinner, frequent short dry cough. For a long time the urine, on emptying the chamber, has been found thick and turbid, with a sediment at the bottom of the vessel. 25th. — No dose. In forenoon an especial feeling of malaise with general discomfort. He frequently coughed up thick mucus, and had pain in stomach and heaviness in r. leg. 26th. — 700 dr. During n.

Icellcnt sleep. In m., immediately after dose, emission of flatulence th upward and downward. He subsequently observed slight burning [ inner side of r. lower leg. After breakfast, weakness in stomach |h confluence of saliva into mouth. While seated at his writing- Ue he felt influence of drug spreading through his system, and had I doubt that if he remained quiet manifold symptoms would soon make their appearance, but he was obliged to go out, and the developnt of the eftects of Thuja was always hindered by bodily movement. 10 a.m. slight burning in stomach and in eyes, slight squeezing uc anus, and short accesses of drawing in r. arm and leg. In open he felt well. After eating ices scraping sensation in throat, unanc taste in mouth, and constriction in region of os hyoides. In tobacco smoke or reading and writing by candle-light produced er burning in the eyes or cough, an intimation that the catarrhal symptoms were the effect of the operation of the drug. 27th. — On ing, eyelids were slightly agglutinated. Some thick mucus was on by slight coughing, and after a papcscent stool, slight ning in anus was felt. The dose of 725 dr. produced, after break- , an unpleasant, resinous, constrictive taste in mouth. As he was ch in open air no other symptom was developed except frequent freezing. 28th. — In m. coughing up of thick mucus again. Immediately after taking 750 dr., tearing in tendinous aponeurosis on the skull (for some m.) ; in forenoon frequent slight cough with raising of thick mucus ^ at noon, great excitement in genital organs, especially tickling in the prepuce and glans. (Z. remarks, " In my case Thuja operated in a striking manner upon the hsemorrhoidal vessels ; for I felt in them^ at times, congestion, and then again such an emptiness, that it attracted my observation even when I was not paying attention to that quarter; and this alternation of sensations frequently took place twice or 3 times a d,") 29th. ^r775 '^^' ^° symptoms the whole forenoon. After dinner, sleepi- ^^bs i feeling of coldness, especially in legs ; a boring stitch on r. wae of under Jaw ; a couple of erections, and on the emission of some very dark-coloured urine, burning in urethra ; late in e., 2 flying, very painful stitches low down in 1, side of chest, 30th, — In m. he several tinnes coughed up thick mucus. After taking 800 dr., burning in isolated spots under skin, particularly on r. side of chest. Towards noon, while walking in open air, a sudden flying stitch darted through urethra, came out from the bulbus, pressed almost to the middle of the urethra, and was so violent that he was unconsciously obliged to bend

over. At 5 p.m., a laming drawing of short duration in r. shoulder a thumb ; soon after, tearing in palm of r. hand near wrist {for \ h.\ At 8.30 he was seized in the street with general malaise and 1 universal debility, with sinking in stomach, that he took a small of cordial at a coftee-house. After a while he felt better again, bur about 10 he felt an indisposition by no means easy to describe in words ; his mind was at the same time wholly undisturbed. It was 1 long time before he could go to sleep, and he awoke in m. earlier than usual. On 31st and the 2 following d. he took no medicine. 31M.-' In forenoon, burning in anus ; at 7 p.m., violent heartburn. Notwithstanding shortness of preceding night's rest, he felt, all d., no tendency to somnolency. The urine was voided very seldom. On following n., a good sleep. Feb. ist. — In m., frequent hawking upo* mucus, sneezing, slight agglutination uf eyes, and burning in r. lower leg. 2nd. — After rising, drawing tearing in r. arm, especially alona; course of ulnar nerve, in r. thigh, in r. zygoma, and in r. side of chest. After a little while these symptoms passed off, and appeared, but weaker, in 1. side of body. 3rd. — In m., coughing up of mucus and a single sneeze. An h. after 850 dr., dulness in head, on r. side of for head, continuing an h., and dryness of nose. After dinner, sligl burning in stomach, heaviness and weariness of legs with dulness of head and indisposition to any kind of intellectual labour. The eves secrete much gum ; face is wan and appearance bad all d. 4th. — No dose. In m., slight dulness of head ; short drawing tearing, now her^^ now there, but always on 1. side of body. In c, burning of eyes, ^s'^^ room were smoky (for an h.). Subsequently debility of legs, and, 01^^ writing, return of burning of eyes. The secretion of urine is very sparing ; and the urine itself soon becomes thick and turbid by standing, and deposits a copious, clayey sediment. 5th. — 875 dr. Thereupon emission of much flatulence j slight pressing on inner side of r. knee ; transient drawing in I. ankle, afterwards in r. thumb, tnd iinally on radial side of r. upper arm, where pain disappeared after 4 h. ; slight griping in intestines, with feeling as though they were pinched with the fingers in a circumscribed spot, now here, now there ; on smoking a cigar, the dryness of nose, which had been already often remarked, came on, and the mucus hawked up had an unpleasant^ sharp, resinous taste. These symptoms vanished in the open air ; but in walking against the wind his eyes continually watered, a thing which had already been frequently remarked, but had not been specially attended to by the prover. After dinner, great inflation of abdomen {for an h.) and a couple of gripes in intestines. In e., slight itching and pressing in anus. 6th. — 900 dr. Immediately after dose, 2 sneezings, which seemed to be excited by a vapour rising from stomach into nose; then a couple of short, dry coughs, and slight burning on dorsum of r. foot. The eyes were somewhat agglutinated and watery in open air. During lecture his voice was hoarse, with frequent inclination to hawk. On coming into the room from open air in afternoon, he had, for some time, painful thumping and roaring in both ears. An evacuation, followed by violent pressing, was unsatisfactory. 7th.^-925 dr. Immediately afterwards, discharge of

\tncc upward and downward ; burning externally over lower ribs of r.

tide; then burning in the stomach, with eructations having taste of T.

during whole forenoon. Burning in stomach again at dinner, which

WIS eaten with appetite (for an h.). For several days past he has

noticed that while he is smoking a cigar, seated at the writing-table, he

ii obliged to cough, dry and interrupted, which was not usually the

cue. In e., on eating fish, pressing and burning in stomach. 8th. —

9504r. Soon after, inclination to cough, and burning in throat on 1.

side near larynx, which afterwards extended towards 1. ear, with more

of a feeling of soreness, and soon after disappeared. Slight constriction

and compression of lower half of chesty and transient stitchy pains on

both sides of thorax extending co armpits. Towards noon, burning at

inus and in r. leg. He felt well in the air. After dinner, slight

burning in urethra when urinating. In e., burning and stinging in

fdges of eyelids (even the smoke of tobacco burns in the nose), with

sticking in nape over joint of atlas (for i h.). The following n. he

iltpt well, and perspired, on awaking, so strongly on the inner side or

thighs and legs, that skin was completely wet, while rest of body was

dry. 9th, — Z, concluded his second experiment by taking 1000 dr.

After dose, burning in stomach (for ^ h.) ; then feeling of coldness over

whole body in a warm room, especially in hands ; rumbling and slight

8''iping in intestines ; somewhat later, creeping shudderings, particu-

'*r/y in back, with hot face ; heaviness of eyelids, with slight burning

of eyes and heat in r. ear. Breathing at same time was easy, and pas-

**ge of air through nose free. The temperature of the open air, 3° R.

'39° F.), affected him so unpleasantly that he trembled from head to

root with cold. After dinner, transient pressing headache in vertex ;

'filing drawing in r. armpit, coming on by fits; occasional drawing in

^* thumb. lOth. — His voice was hoarse during his lecture, and his

^"'■oat so choked with mucus that he was frequently obliged to hawk.

'^fter dinner, burning of eyes again, and somnolency also ; slight com-

P''"^«sion and crawling externally on occiput. After a short and very

refreshing nap, burning in stomach, eructations of wind, discharge of

I "*tulencc, frequent dry cough. lUh. — In m., after a hard scanty

'fool, pressing and burning at anus; also soreness in bend of r. arm

^*^hen extending it (the whole forenoon) ; pressing headache on vertex

*^nd in temples (whole e.) ; feeling of coldness, especially in hands and

'cct, and on anterior surface of thigh down to knee, when seated in

I ^*^arm room. I2th, — In m., coughing, with raising of mucus. In

[ forenoon there was a return of the soreness in bend of arm, but in 9

I less degree than yesterday.

^H (. Z. now instituted an experiment with the diluted Thuja. On ^H t3th Feb. he tasted the loth dil., in order to ascertain if he could dis- ^^ cover the taste of Thuja in it, which was not the case. Thereafter, in "« course of scarce 2 m., the same troublesome dryness in nose ^^^nit on which had been perceived on 3rd of month, and remained for ' '. P.m., he perceived burning and pressing in stomach (for an h.). ^J'h. — 10 dr. of loth dil., which had been previously shaken for 5 m. *"h two oz. of distilled water. In afternoon, burning in stomach (for '" h.), and in c., pressing in hemorrhoidal vessels, I4ih. — Same

^mmk

jHH^g

dose. After dinner, sleepiness, but on lying down on the couch, instead of the expected slumber, painful cold runnings from nape, over back, down to sacral region, which were increased by every movement of body, and soon disappeared after rising. 15th. — For the last time, Z. took 10 dr. of the loth dil. immediately before breakfast {cafe au lait). Shortly after he perceived a sharp taste in mouth, and had eructations with taste of Thuja. He remarks at this point : '^ I must confess that I am not in a situation to account for this symptom. How should it be possible for 10 dr. of the loth dil. of Thuja, drunk in two oz.of water, followed by a breakfast of bread and coffee and the smoking of cigars, to affect the gustatory nerves ? "* The drawing in r. shoulder also came on for a little while. After dinner he was again annoyed by dryness in nose already often described, and burning on tongue; in e., burning in stomach. 16th. — An entirely new symptom made its appearance. As he was going to dinner, there was a sudden sparkling before his eyes, and a multitude of black shining points swam before them, so that he could not clearly make out surrounding objecK. After a while this symptom disappeared, first from r. eye. 26th. — In e., tearing and laming drawing in I. axilla, which on following d. extended to r. shoulder, where it remained an h. On same d. he pet' ccived, for a short time, a constrictive feeling in back between scapuls, which somewhat hindered respiration and also motion of the innt. Afterwards he had a feeling in internal canthus of r. eye, as if a grain of sand had fallen into the eye ; this continued until bedtime, and rendered movement of eyelids somewhat painful, though no objective alteration in the appearance of the organ could be detected. 28th.— The eye had entirely recovered ; but in m. a pressing headache in region of vertex came on for a short time, and returned in e., accom* panied by burning in stomach. No further effects of the Thuja were remarked by Professor von Zlatarovich. {Ibid.)

C. R — , at. 23, unmarried, thin, of a nervous excitable consdtution, suffered when a child from scaldhead, and from worms. She was chlorotic from 12 to 19. The catamenia first appeared in her 15th year; but during the first year they appeared very irregularly', and even at the present time are sometimes absent for two or three months, especially on any violent mental excitement. They appeared last on 23rd Sept., and continued for 6 d., which has been their usual duration for some time past. She has suffered for a year with cramps in abdomen at the time. She has had for some years a flat, dry tetter on chin and iips. 1844, Oct. 17th. — She began the proving of Thuja with 10 dr. of tinct., taken fasting in water in m. Two h. after she perceived heat and vertigo (for \ h.). 18th. — 15 dr. In forenoon, pressing in stomach. 19th. — 20 dr. After dinner, transitory coldnest over whole body. 20th. — 30 dr. She felt well during d. In e. chilliness for several h., passing into heat on lying down. 21 at. —

In our opinion, this taste of T. is to be attributed, not to the 10 dr. of the loth dilution, but to the 40,000 dr. of the mother tincture which bad been previou^l^ taken, which had penetrated and, so to speak, ihujacistd the whole body. A tww reaction tollowcd the new and almost immaterial do^e, and that might c[i*ragxge % perceptible portion ot the previous-ly taken mass. — Mayrhoftr.

3s <'>'. No symptoms. 22nd. — 40 dr. In following n. pain in tc»mich, with nausea and vomiturition (for an h.), 23rd, — 45 dr. Fressing headache through d., beginning on r. side, afterwards extending Over whole head. 24th. — 50 dr. In forenoon eructations with taste ^f the drug and slight headache for a couple of h. 25th, 26ih, and th. — 55, 60, and 65 dr. No symptoms. 28th. — 70 dr. Coldness Id.; cutting above navel, extending into sacral region ; before bed- '^••Tie, difficult respiration with pressure on chest, by reason of which Oe could not get to sleep for a long while. 29th. — 80 dr. In m,, on ^^aking, very violent pressing aching in forehead, lasting all d. The "^^ enses, which should have appeared on 2jth, came on for the first time ^^-day, but unattended with colic. The following 6 d. passed without *^king any of the drug. During the first two, she had continued f^^adache, copious eructations of wind, and wandering, drawing pains * «^ hollow teeth. On ist Nov. she was well. On 2nd she had, in m., ^ three hours' headache, at one time in r., at another in 1. temple, ^tid then in vertex. On 3rd, catamenial flow ceased ; it had been ■ess than usual. 4th. — 85 dr. After breakfast, exceedingly violent ^olic, and transient cutting and rumbling in intestines. 5th. — 90 dr. A return of yesterday's colic, but less violent ; accompanied by weariness and general weakness, with heaviness in legs and general feeling of discomfort. She felt as if she were threatened with a severe attack of illness. 6th. — She awoke with a very violent headache, and took 95 dr. During dinner, very severe, but very transitory colicky pains came on suddenly, and also frequent creeping coldness, as during a fever. On the following 2 d. 100 and 105 dr. produced no symptoms. 9th, — no dr. A.m., feeling of colduess ; p.m., frequent feverish alternations of cold and heat. lOth, — 115 dr. Slight headache all d. On the next 2d. 120 and 125 dr. produced no symptoms. 13th.— 130 dr. She felt all d. weak and debilitated, 14th. — 135 dr. Violent tearing on I. side of head, and in teeth of that side. 15th. — 140 dr. For 4 b. after dose she was as if stupefied, sleepy and weak ; rest of d. well, 1 6th. — 145 dr. She then ceased taking the remedy for 16 d. During this time the results were as follows : — On d. of dose, stupefaction again and sleepiness, which did not last so long, however, as on previous d. P.m., frequent eructations of wind and pressing in stomach, which extended through throat into fauces. Late in e., on L going to bed, tearing on r. side of the head, and itching over whole ^■skin, especially on abdomen, as if she were covered with an eruption. ^■Painful inflamed tubercles appeared on various spots on body. 17th. — I In forenoon stomach-ache and melancholy state of mind j in afternoon more cheerful humour. This alternation of humours has already mani> fested itself for some d. past. i8th, — In forenoon, pains in stomach, hawking up of mucus ; stoppage of nose, with nasal sound of voice; biting on whole body ; in e. sticking in head and transient tearing in I. hand. tgth. — P.m., tearing in teeth of 1. side, and afterwards a very restless night, 20th. — Very severe catarrh with increased secretion in air-passages, painful swallowing, and sticking in head. These symptoms disappeared by degrees on following days, and she continued the proving on 2nd Dec. by taking 150 dr. Soon after dose, stupefaction

3^4

(effect of alcohol ? — M.) and extreme drowsiness during whole d. Dec. 3rd. — 155 dr. Stupefaction, sleepiness, and frequent eructations of wind. 4th. — 160 dr. After dinner she was very thirsty, and so inflated that she could not bear the pressure of the strings about her body. 5th, — 165 dr. Same symptoms. 6th. — Nodose. Extreme melancholy. 7th. — 165 dr. After awaking, very violent headache, lasting all d,, and disappearing on next d., on which dose was omitted. On next 3

d. 170, 175 and 180 drops produced no symptoms. I2th. — 185 dr. After dinner extreme thirst ; in c. colic. J3th. — 19O dr. Colic with two fluid evacuations, great thirst and cold over whole body, with drowsi* ness. 14th. — Nodose. She awoke with sticking in I. side of head, which soon went off ; but head was dull all d. She had also drawing from head over nape and back to sacral region, and complained of general weakness with heaviness and coldness of feet, and in e. of general burning heat, whereupon restless sleep followed. 15th. — She awoke with headache, and took 195 dr. In c. coldness in back with alternations of heat. She has made the observation for several d, past, that on bowing she has sticking in I. side of the head, even if she were not just then suffering from headache. 16th. — She closed proving with 200 dr. The headache with which she awoke lasted 3 h., and after it had ceased sticking pain came on when bowing, but on r. side of head. After dinner, pressing in r. side of the chest during whole afternoon, accompanied in e. by sticking, which extended into sacral region. During whole d. coldness, especially \n back, with general weakness and sensation of weariness. In e. manifest fever symptoms developed themselves, as headache, heat of the skin, full, accelerated pulse, besides sticking in r. hypochondrium (especially during respiration), which extended into sacral region. She went to bed on this account^ and general heat came on, succeeded by quiet sleep. 17th. — There was no fever, but she felt weak. She has had no evacuation for 2 d. past, and no appetite ; bitter mucous taste in mouth. The pains in chest are completely gone j borborygmus is frequent in intestines ; in

e. sticking in head and pressing in t. side of chest. These symptoms are diminished by an evacuation. Sleep was disturbed during n. by heavy harassing dreams. i8th. — In m. headache and cough, with copious excretion of mucus; catarrh and bitter taste whole d., thirst with alternations of heat and cold, latter especially in the dorsal and sacral region, with hot head and face. On going to bed pressing on chest, with difficult breathing and sticking in side. Before midnight, cold> ness ; towards m., warmth ; 'finally perspiration. 19th. — On rising, violent sticking in head, especially on moving ; great accumulation of mucus. In forenoon alternations of heat and cold. Towards noon headache became very severe, and remained so for \ h. ; there came on then drawing in sacrum (aggravated while seated), stoppage of nose, burning of eyes, frequent eructations of wind, difficult, almost panting respiration, violent cough with raising of mucus. In afternoon, slight colic, with borborygmus and inflation of abdomen. In e. general chilliness without thirst. Pulse was 100, full and hard. Several inflamed tubercles appeared in face. Her food tasted insipid. 20th. — During n., in which she continually suffered from severe coldness, the

catamenia appeared, 10 d. earlier than usual. In m. she felt very ill ; her bead was dizzjr as if stupefied, her mouth tasted very bitter j all her teeth seemed to be loose ; she frequently coughed up mucus as thick as lard. In forenoon she felt pret^ well. Towards noon, alternad(HU of heat and caid came on, with weakness to the extent of filing. In afternoon she felt well i^n except a slight headache. Catamenia very scanty. She has observed for several d. past that she hecomes hot at dinner, and her body is covered with perspiration. 2ist.— During n. she slept extremely restlessly. So bitter was the t>ste in her mouth that she was obliged to get up and rinse out her ■nouth with water. She awoke at about 3 a.m., and could sleep no "■ore on account of heat. Afterwards a chill came on, and in m. a ^^7 violent headache, lasting all d. Before dinner she fielt weak and y^y, and was cool over whde body. She felt better in e. 22nd. — ^ m., headache, but less than yesterday ; firequent spitting of saliva ^d mucus, with hoUowness at stomach and insipid taste. General . '"ig of discomfort ; she looks very ill, is weak, depressed in body and "^'mind, and is somewhat bloated in ^e. Towards noon, an attack of ^"coughing, with raising of tenacious mucus, vomiturition and strangling ; ^^ this she felt ill and weak for \ h., and had a return of more ^^lent headache. At noon everything tasted insipid. In afternoon, ^'^cti walking, great heat, weight upon chest, breathlessness, and occalotial dry cough, with sticking in head. In e., coldness in the back, ^^ompanying heat in head, with great drowsiness and thirst ; at n. ^^et sleep. 23rd. — ^In m. bad taste in mouth ; less sticking in head ^haii yesterday ; she feels very hot and weak, and is frequenuy obliged ^^ iit down to rest, although she insists upon it that she is better ^p-day than for some days past. She coughs very little ; has shorter ^feath than usual, with weight on chest ; urine is copious, she has had Do evacuation for 2 d. In e. chill again, followed by heat, thirst, and sleepiness. Pulse 120, full and hard; she is very low-spirited. 24th. ^-Tbe same symptoms appeared, accompanied by tearing in hands ; in e. feverish pulse with headache ; a good night's rest. 25th. — In m. headache ; also violent tearing in nape, which extended into axilla, and there remained during whole d. Upper arms are painful, and so weak that the patient can with difficulty hold them up long enough to arrange her hair ; she trembles in hand and foot, looks pale and earthy, is exceedingly out of tune, sad and disposed to weep} respiration very short on walking, cough dry, abdomen very much inflated, taste bitter, increased thirst ; alternations of heat and cold i pulse not so much accelerated, nor so full as yesterday. A hard evacuation. 26th. — Patient feels so weak and powerless that she cannot leave her bed. Her head is very dull ; she is as if stupefied and dozes much ; her tongue is somewhat furred and half dry ; pulse moderately accelerated, full and hard. To these symptoms were added cough and tearing in 1. shoulder. This sute of things, in connection with a very sickly countenance and extreme prostration and depression of spirits, gave Z. reason to apprehend the development of a nervous fever, and he gave her a drop of pub. 30. She continued the same for the rest of d. j she had occasional nape during n., but they were disturbed by tearing

in 1. axilla and slight colic. 27th. — In m., same state of things, but ia somewhat diminished degree. Tongue dry at point. In afternoon, bitter taste, redness of face with cool extremities, irritable humour. She had cocc. 30, one dr. In e., copious general perspiration, with diminution of all the morbid symptoms, and tolerably good sleep at o. 28th. — In m., striking abatement of all symptoms. Skin is agreeably moist, pulse less accelerated, feelings less gloomy ; tongue is »tiU somewhat furred, and tearing in 1. shoulder is still present, but at times it goes to r. shoulder and nape. She begins to feel a little appetite, and has had two stools; but she still feels very weak, dozes much, and speaks very slowly and monosyllabically. She had cocc. 30, one drop in a tumbler of water, with directions to take a tablespoonful every Z h. The improvement continued during d., and she had a good n. 29th. — The pains are considerably diminished ; the fever is slight, tongue moist, taste natural, mind cheerful. At n., sleep and copious perspiration. Cocc. continued. 30th. — In m., patient is excccdtngljr ill-humoured, speaks but little, and keeps her eyes continually closea. For the rest, she complains of no pain, pulse is but slightly accelerated, and there is nothing further worthy of remark. Z. gave her rbus 24. She sleeps much during d. and has no appetite ; tongue is moist and « litile furred ; urine copious and yellow. She slept and perspired at n. 31st. — With the exception of great weakness and prostration, no morbid symptoms appeared to-day. In afternoon, nose bled, after which .head was much relieved. '^ It must be observed," remarks Z. in his relation, " that both those about the patient and she herself had noticed that she was better and worse on alternate d., indications of a tertian type. I must confess," pursues he, '■'■ that I have no hesitation whatever in considering this whole attack as caused by the Thuja. Had it been a natural idiopathic aiFection, there would have been a greater harmony in the symptoms. The febrile symptoms, however, stood in no relation to the extraordinary debility ; there were abdominal pains, no diarrhcea, no delirium, no meteorismus, nor any those symptoms which usually indicate the existence of a typhoid dt ease."* 1845, Jan. ist. After a good night's rest, the patient, with the exception of general weakness, which was still present, felt well. Her appetite returned ; she was not so depressed in mind as on the preceding days : but her speech is still very slow and drawling. She took ignat. 24. At noon she was for a short time out of bed, and remained well during the afternoon. 2nd. — The catamenia appeared without any morbid symptoms, but lasted only one d. 15th. — For the Hrst time the convalescent went into the open air, which seems, nevertheless, to have been too soon ^ for on i6th chills, want of appetite, peevishness and a small weak pulse again made their appearance. She now took nux vom. An h. after, a shaking chill, lasting ^ h. ; heat came on over whole body, preceded by a gradually increasing warmth. She was so weak that she was obliged to remain in bed all d. She bad a thickly

• We do not for an instant doubt but that »he above-described attack wa« the result of the doset of T. ; we recognise in the instability of the symptoms, in their evident discordance, and in the irregularity of the course of the disease, the funda. tnental charactcriuics of the drug.— Ma^Aqfir.

coated tongue with bitter taste, but little appetite, and for 2 d. past no evacuation. The febrile symptoms were slight. The nux was continued. Next d. she was better throughout, tongue cleaner, appetite returned, had a stool, increase of strength. The convalescence now steadily proceeded without any further medication, but it was a full month belore she regained her former health. [Ibid.)

Frakz Zoth, medical student, act. 24., choleric-phlegmatic temperament and apoplectic build j at 15 had typhus ; a year ago wu treated for 10 d. at the medical clinique for an inflammation of the lymphatic glands of the r. arm, which had came on in consequence of intoxication with cyanide of potassium ; in other respects was entirely well. Zoth's proving produced very few results, notwithstanding he took 5000 dr. of the tinct. within three months. 1844, Oct. 15th, 16th, 17th and 1 8th. No effects were perceived from 5, 8,11 and 14 dr. 19th. — 17 dr. He perceived single stitches in r. frontal region. On following 2 d, 20 and 23 dr. produced no symptoms. 22nd. — 26 dr. A cough came on, which he regards *s having been possibly caused by an exposure to cold. The cough continued on the following 2 d., on which 29 and 32 dr. were taken. 25th. — 40 dr. To the cough was added swelling of throat, which continued during the following 3 d., on which 50, 60, and 65 dr. were taken. From 29th Oct. to 6th Nov. Z. increased his <ioK 10 dr. each d., so that commencing with 70 on the ist d., he took 'SO on ihc last. The provcr's diary contains nothing remarkable for these 10 d., except that the excretions were increased in quantity, and were less consistent j which remark will also apply to the previous days. From 7th to 22nd Nov. he continued the Thuja in a similar ascending •cale of doses (by 10 dr. ad.), and took on last-named d. 300 dr. The fesults were as follows : 7th. — Painful throbbing in base of glans (for 4 m.); afterwards, pains in lower half of spinal column and in the **crum, continuous, aggravated by bending body ; also in both knees. These pains continued also during following d., and were attended by greit general weariness. 9th. — Having taken much exercise this d, 'he pains became less; on loth, however, they became more violent, decreased by degrees on following days, and finally ceased on ibth, on *hich d. he took no dose, 17th. — These pains returned again, and *ere especially violent in both hips, weaker in sacral region and knees. '8th. — They ceased in sacral region, but continued in hips and knees. 19th. — An eruption upon an inflamed surface appeared on 1. side of chin, 22nd. — Violent buzzing in ears, lasting several h. From 23rd W, to 5th Dec. the Thuja was omitted, and all the previously

scribed symptoms vanished. From 6th to 20th Dec. he again continued the experiment, taking on first d. 310 dr., and daily increasing ^^dosc by 5, until he arrived at 380 dr. on the last d. He observed no ^^BSects. From 22nd Jan. to 2nd Feb. he made a short experiment with ^Tilutlons, and likewise perceived no alteration in his sensations. {Ibid.)

Dr. ZwKRiNA, «et. 36, perfectly healthy, and of a sanguineocholeric temperament, proved the Thuja as follows : 1845, J^''* a3rd. — He began with 40 dr. of tinct., which he took at 9 a.m., an h. after breakfast, and observed no other result than that during the

Biesc

following n. he was obliged, contrary to his usual habit, to rise three times for the purpose of urinating. The urine passed was stnwycllow, and amounted to a full measure. On following d. he took nothing, and observed no symptoms which he could ascribe with confidence to the drug. 25th. — 30 dr. taken at about 9 a.m. At noon, slight burning in urethra, leaving behind a voluptuous feeling, especially after urinating. The quantity of water passed was again increased during n, ; it was clear and straw-yellow. Sensation of great fatigue in groins. His appetite was small, and his customary morning evacuation did not take place. 26th. — To quicken the action of the drug the impatient prover took 50 dr. m. and e. Immediately hereafter, burning in urethra and copious urine ; the customary daily evacuation absent. Disquieting dreams, frequent urination and four pollutions disturbed an unrefreshing night's rest. Sleep came on late, an unusuiJ occurrence with him. 27th. — These symptoms did not deter prover from taking loodr. this d., fasting. Thereupon he experienced headache in region of forehead and eyebrows, such as usually precedes a catarrh ; ill-humour, lasting all d. ; want of appetite, with frequent eructations i repeated shuddering, beginning at head j slight burning in region of kidneys, ceasing after an h., and followed by still more copious urine,, accompanied by burning. The feeling of fatigue in region of groins passed into a drawing pain extending into glans penis, and inguinal glands were perceptibly swollen. A general feeling of malaise, with internal chills, came on, and instead of his usual cheer' fulness, peevishness. For 3 d. he has had no stool. 28th. — Notwithstanding this, he again took 100 dr. early, fasting, "and now," says he, ' for the first time the drug fairly mastered the health that had so far defied it." An h. after the dose, the burning in renal region increased, and was accompanied by drawing along ureters to vesica i the urine diminished in proportion as burning in ureters increased. The glans began to grow moist and to secrete a thin mucus. In e. he had a slight chill, attended by dryness of throat, with painful deglutition, vomiturition, and such a feeling of illness that he was obliged to go to bed before the time. His interrupted sleep was full of anxious dreams, and he continued the fourth d. costive. He was now so we»» satisfied with the pathogenetic effects of Thuja that he dropped the experiment. By degrees his abnormal symptoms disappeared; ftr' the headache, then the dryness of the throat, and lastly the rcn** affection j, on Feb. ist, after a constipation of 8 d., he had a copioii** hard evacuation. {Ibid.)

»j. The following pliysiologicaj proving of T. by our colJeiguc, I'' HoLLECZEK, practising physician in Klagcnlurt, has only reached us while th*^^ sheets are going through the press. It contains, for the most part, only subjece^^^ tymptoms, and adds scarcely any new lines to the portrait of the T. sicknevs dcpice*^ by tne experiments already detailed. Dr. HoUeczek has a strong constitution j f»^ an intermittent fever at twelve years old, but was otherwise well until his «**V— year. He then had a slight attack of pneumonia, and was perfectly restored in a ■'^ days by homoeopathic treatment. He has had no other sickness. At the time o^,^ first experiment he was aj years old. The symptoms below follow in chionolo^* order.

a. Sept. and, 183I. — He drank at one draught Jss of the strong tiocture of ding to Hahnemann's directions, having first well mixed it with 9

prepared accordi

ofwiKr. Violent pressing headache in region of vertex j sensation as though some. thine were squeezed out at both ears ; heat in face (immediately); feeling of heat in whoir chrit ; stitcher in temporal region, in elbow and heels. Pressing pain in ewipul ; head pains^ as though it were stuck through from one temple to the other ; •lighl eructations (all d.). Stitches in metacarpal bone of little finger. Stitches in onb. cordis ; sticking beating in middle of r. side of chest ; stitches in cardiac ttgioo; pressure under sternum i slicking in pit' of throat. Drowsiness; violent

{irwing pain in occiput j feeling, when turning head to one side, as though a piece of tail lay in brain. Stitches from spine through epigastric region, forward to pit of i*»iucli; frequent sticking pains in r. shoulder-joint; repeatedly during d. a cutting pain perpendicularly through middle ot chest from below upward as tar as pit of cKroai ; iticking pains in forehead ; extremely violent sticking pain in metatarsal bone cf middle toe of Both feet ; pressure on r. side near scrob, cordis, as if from a foreign Iwdy, with frequent stitches, worst in m. Itching on inner surface of prepuce j Wrtinely violent pain in middle toe of r. foot ; several stitches in interior of r. ear ; PMful, frequently repeated stitches in r. testicle; dreadtiil tearing pains, which darted '<li( lightning hither and thither through urethra, with simultaneous violent stitches ■nanus (p.m. when seated). Quivering twitching from ear to 1. corner of mouth j ^ciciag pains in I. shoulder-joint ; tearing pains in metatarsal bones of r. foot; dull 'Peking pain in metacarpal bone of middle finger of 1. hand; sticking in great, fourth, and little toe of I. foot. Pressure in larynx; sensation of burning and confiction of larynx; tearing pains in under jaw, which began on both sides, in region *•' joint, ran forward together in a line to chin, united, and instantaneously dis- *pptired. Painless twitching of middle finger of r. hand ; very painful stitch through k Spper part of 1. breast from before backwards, xvhich immeJiately disappeared, and iKft a teeling of twitching in spot ; tearing paires in bones of I. forearm and wrist; **'tchfs in point of third finger of r. hand; sricking in sole of r. foot, from within out^^rds; feeling of dislocation in middle of spine, increased on r. side by strong '*nding of body.

Sept. 4.th. — Same dose as on and. Pressing headache on vertex and occiput, [•!» sensation as though there were lead there, aggravated by moving head and by a ™^l*«<tep, v»ith feeling as though brain were loosely moving about; when lying on "<? It, beating in chest under sternum, extending to sacrum ; while lying on r. side, "^^xiy stitches in same side of abdomen, which aisappearcd on pres^sure, and returned •" vralking in open air ; in e., when walking in open air, feeling of fulness and pres. ?•«■« in occiput j on moving head sideways, vertigo. Constant painful pressure "^^rardt at nipples; painful pressure in r. abdominal region, which disappeared •** making pressure there with hand, but became sensible again (during whole d.) °** taking a deep inspiration, or on forcibly expiring ; constant tearing pain in "'^t-jtirsal bone of r, middle toe; stitches in both knees when walking. Cough, '"•th expectoration of mucus, when eating; after eating, cough with raising of a l^Ugh mucus; sticking headache in region of vertex; painful tension in occiput f''^i5i one ear to the other. Little thirst; urine with a penetrating odour. Stitcnes 1^ r. mlit-joint ; boring from without inwards in region of r. iliac bone; sticking "^ middle of sole of 1. foot, from within outwards; a quick drawing, borine ^>n through forearm and metacarpal bone of index finger; painful tension of Togastric region with occasional sticking pains, aggravated by deep inspiration '** roreniKin with an empty stomach) ; painful stitches in skin of 1. elbow, filling in middle of chest upwards into neck, inducing difficult respiration j "~'ing pains in region of heart ; constant pressure in middle of chest, with sticking > during attempts to inspire deeply ; frequent creeping chills; pressing pains in hk upper part of chest, becoming much more violent by pressure; cuttmg pain SIS spine to pit of stomach. Sensation as though r. side of scrotum had been [oiMistd; cutting pain deep in I. side of abdomen ; seasation when bending forward* T brain were pressed out at vertex ; sticking in r. thumb; tearing in r. tarsus and ;toe: cutting in 1. side of upper lip ; dull pain anteriorly in Tower third of r. _ t ; sticking in bones of lower leg from tarsus up to knee ; tearing in scrobiculus ; An bending body to r. side, tearing in r, popliteal space. Fine sticking in 3rd joint Of ii ' ^ (.1, from within outwards; violent stitches in anterior extremity of uret t urinating ; sticking in external malleolus, hip-Joint, metacarpal bone

0/ niiuuii: linger, on inner edge of foot, in heel; dull sticking pain in joint where VOL. IV. 24

ijo

thumb and index are articulated with meucarpus; dull sticking in interior of r. ta r Twitching ol muscle* on r. forearm j feeling, when seated, as though the chc»' wrn: compressed from before backwards, aggravated by stretching boify ; painful stitches in interior of 1. chest ; dull cutting under 1. shoulder-blade ; cutting paiooO 1. side near scrobiculus. Stitches in i. testicle (for 8 d.) ; when coughing, dull slicking pains in r. inguinal region; violent sticking in region of iplttn, <t"rir.,' ± meal ; very violent stitches in toes, noon and c., on bending body to (. side i Sticking pain in liver, when walking; stickingi pains in r. elbow; sticking i carpal bones of 1. hand ; oppression of chest j necessity of frequent deep breatamgi dull sticking pain in I. panetal bone ; sticking pain in brain from neck up to rma; stitches through brain from below upwards, especially when coughing; stitches m L ala of nose ; vague stitches in I. lung ; burning in forepart of urethra, without mf discharge ; drawing slicking pains in liver; cutting pains in rectum.

f. Oct. 3 1st. — S dr. of ine tinct. in a tablespoonful of water. Sticking in <«robi> cult!-, j sticking beating in fossa navicularis ol urethra (coming on daily for a week* at irregular intcn'als, and frequently repeated in an h.) ; sticking in region of tplffft at indeterminate times, but particularly during dinner and supper (at iotcrrih of 4. d.) i an evacuation early every d., with urging, although only a small quantity of thin fWccs was quickly passed, afterwards feeling of inactivity in tectum. Vcrtig«, coming on of a sudden after dinner (while looking up) ; head.iche in occiput j preBing with stupefaction when moving head to one side. Corroding aching 01 • hi.\f of scrotum. All the diameters of the chest seem to have become shorter ; tension in whole chest when inspiring deeply; sensation of want of plijj thorax and of insufficiency in inspired air; at n. short breath ; necessity to breathing deeply. Violent cutting in point of tongue and on its under cutting in upper eyelid; quivering of muscles of I. thigh just above knee; viokiil pressing pains in 1. ell)Ow, as if in bone.

J. Nov. 15th. — 15 dr. of tinct. at a dose in a tablespoonful of water. Stickiif in middle of r. side of chest near sternum (in i h.) ; stitches like lightning traitsYrrKi^ through chest. Tearing pain in tendo Achillison r. side; strong extenMon of r. knee impossible on account of a sensitive, painful obstacle in popliteal fipace ; Name tyiiw ptom in 1. knee; cutting pains through chest in different directions; utitches in r. tendo Achillis. Twitching pains under heart ; tearing and sticking pain in ill joints ; stitches through whole brain from below upward. Burning when urinating) burning and sticking in forepart of urethra. Cutting in r. iliac region ; tearing in r. hip-joint; tearing in I. little toe; violent sticking on outside of I. knee; violcfit sticking under r. knee; stitches in sole and palm; itching in rectum after iMol; t>oring, as of a worm, in rectum, from within outwards, after an evacuation.

t. 1840, Jan. 6th. — Ten dr. of 4.th dil. (5: 95) in an ounce of water. Vertigo, when seated, returning as though in poussees every ro, (after ^ h.) ; sennation u though brain were raised several time* in succession ; very painful stitcli on r. li^e near sternum on fourth true rib, repeated in only one spot ; dull sticking pain io I. forearm, near elbow : tearing pain in r. shin>bone from knee down, and from tanui up to knee (subsequently repeated) ; sticking pain in r. knee coming from popliteal space ; sticking in 1. elbow. Excevsive rumbling in abdomen j dull sticking inn r. car and under lobule outward; twitching in muscles under 1. scapula; very paitt* ful tearing in r. tibia downwards (whole d.) ; cutting from below upward on r. itde near sternum. Frequent eructations ; tearing in I. leg downward ; pressure on sternum not affecting respiration ; pressing feeling in pelvic region on r. side tat linea alba, as if from a foreign body, 71b. — Fine superficial sticking in points of fourth and little toe; continual dull sticking pain in 1. shoulder-joint ; tearing pain from ischium through posterior part of r. thigh, as far as popliteal space j cutting through the 1. half of under lip, from below upward; twitching in integument of occiput, on r. side ; violent ringing in both ears ; in e., sticking in 1. palm ; teuing in outer border of r. sole.

/ Jan. 8th.— Fifteen dr. of md dil. (5: 95). Dull confusion of occiput, ending in pressing headache which lasted ) h.; sticking on r. side, near the tniddlt portion of sternum ; several stitches coming from interior of chest ; twitching in r. ear with sticking pains ; both ears stopped ; tearing in leg; stitches in brain, frotii (x-cipital foramen upwards ; tearing in r. eyeball ; sticking pain in I. elbow vrveral times during d.; tearing in r. eyeball, coming from brain; sticking on 1. side, Dev

sparing

Krobirulus, from within outwards ; sticking and ringing in r. ear ; sticking pain in r fomrm near elbow ; tearing in meiararpal bone of Tittle finger ; frequent tearing in great toe of r. foot; dull sticking near middle portion of sternum on 1. side; , lejuing pain in metacarpal bone of index finger ; dull sticking in 1, frontal region { 'ng in r. shoulder-joint j stitches in r. metacarpus and in 1. eyeball j cutting I point of I. scapula through chest ro edge of middle portion of sternum ; stitches in founh toe of I. foot, in I. sole, and in r. thigh, gth. — Early, after rising, ringing ia can i sensation of heaviness in occiput J cutting under sternum, which embarrasses rc»pi™hon; rutting in r. side of chest, extending from sternum to r. elbow; very stool, half fluid, with sensation as if rectum were very inactive; feeling in ! as if a nail were driven in there ; very violent cutting in both loins when ting; ringing in ears, frequently during d. loth. — Cutting in urethra from "ioaruai forward ; very violent, dull sticking pain in r. testicle ; tearing in 1. knee; in ears ; evacuation slight, not satisfactory ; sticking pain in pelvic region c. tide near linea alba; sticking in splenic region, nth, — Sticking pains in I. tide, several times during d. ; tearing in r. carpus ; severe cutting pains in urethra swal region) ; dull stitches in rectum upwards ; stitch from foramen magnum ugh brain to vertex; dull sticking pain near lower part of middle portion of lum, on r. side; tearing in r. leg; no evacuation ; cutting in epigastrium, from c outward ; feeling, when laughing moderately, as though ihorax were strongly »pra>ed, with f>hortnes> of breath ; dull sticking in popliteal space impeding oion of leg. lath. — Tearing in r. lower leg; sticking in I. knee, ra. in bed; inldull stitches near scrobicuius on I. side; tearing in metacarpal bones ofr. ^ni; sticking pain on 1. side from sacrum to testicle; tearing in I. lower leg. U'".— In open air, tearing pains in region of heart, and from there into I. scapula j 'ticking in I. knee; tearing in I. lower leg; roaring in ears. 14th. — Tearing in Wh leg and in r. thigh. 1 5th. — Tearing in r. thigh ; ringing in ears several times louring d. ifith.—Tearing in r, foot.

f. 17th, — Ten dr. of 1st dil. in an ounce of water produced no new symptom, Thtilmost exclu-iively subjective symptoms which prover noted from 17th to 10th fli wirmarily as follows: Sticking in and on almost every part of body — on »m?x, through brain, in eyeball, in sternum, under nipples, in ribs, through chest, ^inicapuh through heart, in groins, maxillary bones, shoulder, elbow, and knee. j«imj, 10 ankle and wrist, os ilium, thigh, calf, arm and forearm, metacarpal and metKipjl bones, tendo Achillis, final joint of thumb and great toe, at root of nails ofthumb and index finger. Tearing in concha, eyeball, scrob. cordis, shoulderl'l»<ie,ihouldcr and hip-joints, thigh, from ischia to knee, in leg, in arm and fore- MB; rutting in perineal portion of urethra; twitching in flexor of I. thumb, in r, <W, under scapula ; sensation of dislocation in knee and hip.joints (aggravated by "Hiking in open air) ; painful oppression under sternum (increased by deep inspira- 'ioDland in inguinal region ; ringing in ears for several h. ; roaring in ear (early in k"!); increased urgency to urinate; feeling of compression in testicle; scanty, |>»|>Hctnt stool. (IbU.)

Dr. HOLLECZEK also caused three experiments to be made by his sistei JoHpha, a healthy, active girl, set. 17. Like those of her brother, ihey produced for 'k« tno»t part only subjective symptoms,

a. lt^o, Jan. 6th. — Ten dr. of 4th dil. of Thuja in an ounce of water. During *"ic d,, sensation as though skin on temples and forehead were shrunken and hara, continoing i h. ; drowsiness ; fine sticking in inner malleolus of r. foot ; sticking ■ tgion of spleen, twice in succession, with consequent soreness there; pressing •""J Srit sticking under sternum ; sensation of weakness in both knees (disappearing <o r. in 10 m., in 1. after an h,) ; sticking in region of fifth true rib on r. side; great luitudc and weakness in both arms, with frequent tearing in them ; vertigo ; I ■'ptficiil headache, as if skin were rendered tense on all sides ; frequent yawning ; LCulh over whole body ; sticking in 1, palm, r. axilla, and near pit of chin ; head- Lttiie in forehead, pressivc, the whole d. ; pressing in eyes ; chills in e. in bed ; il stitches in r. axilla and temple. On following d. repeated tearing in forehead •ticking in different parts of body (elbow, tibia, mammse, chin, scrobicuius, mpula, i&hdulder-joinis).

i. Jan. 8th. — Fifteen dr. of ind dil. The same d. tearing (in sacrum, in nape, om tcinple, in knee-joint, in tarsi and some of the finger-joints) ; sticking (in ear.

under jaw, in splenic region, hip-joint, iliac region, in middle of thigh tai tarsus, shoulder-joint, arm and f'orearni, wiist) ; both these feelings lea iiticlcing, most on r. side ; ringing in ear« ; heavinets and tension in back; i of Doreness in scrob. cordis. The symptoms developed from 9th to i6ih more than a repetition of those already given. She had sticking^ And iometiraes in the same pans, sometimes in others (ear, ear-cartilage, ala near sternum, in epigastrium, between shoulder-blades), and sometimes il limbs (on 9th, in e. in bed). She also complained on 9th of stoppage of t and on loth of painful soreness in middle of back, and pain as if bruited shin-bone.

f. Jan. 17th. — Ten dr. of ist dil. in an ounce of water. The 66syinpTai the prover perceived and noted during the experiment, from 17th to »ist Jai mostly also of sticking and tearing, now in this and now in that part of th scarcely a spot was intact. The pain seems for the most part to have been t I only find recorded on i8th a sticking in the left iliac region " lasting all aist she had a tearing in 1. forearm, shooting from elbow to fingers so that suddenly flexed. On 18th she had beside sticking and tearing, " feeling a* ■ in back and buzzing in ears." There is only one objective symptom m ad the sudden flexion of the fingers just mentioned, " increased secretion of ui d. of dose. (IbiJ.)

On lOth July, when taking a walk, I happened to arbor vitse laden with green cones. I plucked one, chewed it and thought no more about it. That same e. I observed a v( agreeable scalding on making water, which continued all next < I was horrified to observe on undressing that my shirt was spo over in a manner extremely repugnant to one's notions of bility. I found a considerable gteety discharge from the ureth was evidently swollen and inflamed, as the stream of urine and split, and the burning had increased. I had quite forgot circumstance of having chewed the Thuja cone, and could not what could have produced in me, a decent paterfamilias, such incongruous complaint. The following d. the discharge had yellow, while the other symptoms remained as before. I now bcred the cone-chewing, and regarded the malady with more coe I resolved to take no medicine to interfere with its course. T charge still continued, though in diminishing degree, till the 15 the scalding and interrupted stream of urine were by that tin and on the i6th I was again quite well. The symptoms wh lasted were precisely those of an ordinary attack of gonorrhoea, b medicinal origin was evidenced by the short duration of the I should add that two colleagues, who, at my suggestion, cl cone as I had done, were unaffected by it. (Dudgeon, Brit, j Horn., xxix, 185.)

Thuja occidentalis

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