An alkaloid, obtained from several species of Strychnos, especially from Strychnos nux vomica, L.

Formula

, C21H22N2O2

Preparation , Trituration of the alkaloid, or solution of its salts.

Authorities. ( 1 to 18 , from Noack and Trinks.)

1 , Andral, in Magendie, Journ. de Physiol., July, 1823; 2 , Hirl, in Dierbach's Neuesten Entd., 2, p. 536; 3 , Richter, Preuss. Med. Vereins-zeitg., 1834, 36, vom salpeters Strych.; 4 , Blumbach, Würtemb. Med. C. Blatt., 1837, 1, bei einem 17 Jähr Burschen v. 2 scrupel Strychn. pur.; 5 , Burdach, Preuss. Med. Vereins-zeitg., 1837, p. 115; 6 , Weyland, Casp. Wochenschr., 1840, 24, vom Strychn. nitr.; 7 , Behrend, Preuss. Med. Vereins-zeitg., 1840, vom Strychn. nitr.; 8 , Beck, Würtemb. Med. C. Blatt., 1844, Nr. 25; 9 , Provinc. Med. and Surg. Journ., 1845, December; 10 , Schmidt, Preuss. Med. Vereins-zeitg., 1845, 9; 11 , Sichel, Annal. d'Oculist, 1846; 12 , Theinhardt, Casp. Wochenschr., 1846, Nr. 9; 13 , Huss; 14 , Civinni; 15 , Oppler; 16 , Pritzou; 17 , Trousseau and Pidoux; 18 , Carron de Villard; 19 , Dufresne, Bibliothèque Homéopathique (Lond. Med. Gaz., vol. 10, 1832), a lady, æt. 40 years, took for facial neuralgia a hundred millionth of a grain of Strychnine; 20 , Philalethes, Lancet, 1834-5 (1), p. 256, a woman took five pills containing an unknown quantity of Strychnine; 21 , Dr. Epps, Lancet, 1836-7 (1), p. 133; 22 , Dr. Wegeler, Casper's Med. Woch., 1840 (A. H. Z., 19, p. 222); 23 , same, Nitrate of strych.; 24 , Wehand, Casper's Med. Woch., 1840 (A. H. Z., 19, p. 223), a woman, æt. 35 years, subject to epilepsy, took 3 grains; 25 , Ludicke, Journ. für Pharm., 4, p. 199, a woman, æt. 40 years, took 1/24 grain Nitrate every three hours, then 1/12 grain six times in succession; 26 , Schmied, Schweizer's Zeit. für Nat. und Heilk., vol. 6, 1841 (Journ. für Pharm., 4, p. 199); 27 , Scheible, Annal. des Staats-arzneik., etc., 1843 (Brit. Journ. of Hom., 3, p. 61), death of an apothecary; 28 , Fohr, Zeit. Für Rat. Med., 1844 (Journ. für Pharm., 4, p. 199), a man, æt. 60 years, took of a solution of 2 grains Acetate to 1 ounce, 15 drops three times a day, increasing by 2 drops daily, until at last he took 40 drops at a dose; 29 , Wimmer, Neue Med.-Chir. Zeit., 1844 (A. H. Z., 28, 158), effect of inunction of a much as 1/4 grain Strychnine in the temporal region; 30 , James Watson, Lond. Med. Gaz., 1846, fatal poisoning of a girl, æt. 13 years, by three pills, each containing 1/2 grain; 31 , Prov. Manchester Courier, abridged in Dublin Med. Press, 1846 (Month. Journ. Med. Sci., vol. 6, p. 141); 32 , Comach's Month. Journ., February, 1846, p. 141 (Guy's Hosp. Rep., 1856 (2), p. 348), a woman, æt. 35, took 3 grains of powder in tea, death in three-quarters of an hour; 33 , Cattell, Brit. Journ. of Hom., vol. 11, p. 173, Nitras; 34 , Report of Drs. Allen, D. Warner, and Russell, on death of Dr. William Cullen Warner, Bost. Med. and Surg. Journ., vol. 36, 1847, p. 209; 35 , Hampshire Independent (Lancet, 1848 (2), p. 543), Mrs. S. swallowed some Strych., death in an hour and three-quarters; 36 , Dr. Thomas Anderson, Am. Journ. of Med. Sci., 1848 (1), p. 563, a man took 3 1/2 grains for tic douloureux, and five hours later a second dose; 37 , Pharm. Journ., vol. 8, 1848-9, p. 298, a woman took 3 grains in liquid, death in an hour and a quarter; 38 , A. B. Shipman, Bost. Med. and Surg. Journ., vol. 41, 1849, a medical gentleman took 1/4 grain of Sulphate; 39 , A. W. Munson, Bost. Med. and Surg. Journ., vol. 42, p. 43, Mr. G., æt. about 40 years, swallowed probably 1 or 2 grains of Strych.; 40 , George Bennett, Lancet, 1850 (2), p. 259, Amelia H. took 5 drachms of a solution of 10 drachms of cinnamon-water and 3 grains of Strych.; 41 , Jahrbuch für Prakt. Pharm., 1850, vol. 21, a boy, æt. 7 years, having worms, was given Strych. instead of Santonin; 42 , Dr. Dresbach, Western Lancet, 1850 (Am. Journ. Med. Sci., New Ser., 19, 1850, p. 546), a man, æt. 24 years, took 3 ounces of a solution containing 1 grain to the ounce; 43 , Edward G. Bartlett, M.D., North Am. Journ. of Hom., vol. 1, 1851, p. 469, a man, æt. 22 years, took 3 grains dissolved in water; 44 , J. C. Foster, M.D., Lancet, 1852 (2), p. 33, S. S., æt. 52 years, swallowed a solution containing 1 grain; 45 , I. Pidduck, M.D., ibid., p. 80, a man took two doses of 1/6 grain in sugar; 46 , T. Hillier, Med. Times and Gaz., 1854, p. 316, A. B., æt. 18 years, took 2 grains; 47 , Henry Lonsdale, M.D., Lond. and Edinb. Month. Journ., 1855, p. 116, death of a man, æt. 59 years, in an hour after 1 1/2 grains; 48 , Pharm. Journ., vol. 15, 1855-6, p. 478, poisoning of a woman æt. 28 years; 49 , G. J. Hinnell, Med. Times and Gaz., 1855, p. 413, T. M., æt. 33 years, ate 4 to 5 grains on bread; 50 , J. J. Lescher, M.D., Am. Journ. of Med. Sci., New Ser., 29, 1855, p. 269, E. W., æt. 30 years, took 4 grains after a hearty breakfast; 51 , F. Ryland, Assoc. Med. Journ., 1856, p. 500, a man took 1 1/2 grains, death in five hours; 52 , Dr. Geoghegan, Dublin Med. Press, June, 1856 (Guy's Hosp. Rep., 1856 (2), p. 352), a man took 5 grains, death in twenty to twenty-five minutes; 53 , A. S. Taylor, M.D., Guy's Hosp. Rep., 1856 (2), 352, John Parsons Cook took an unknown quantity, death in one hour and a quarter after last pills; 54 , Drs. Lawrie and Cowan, Glasgow Med. Journ., July, 1856 (Brit. and For. Med.-Chir. Rev., 1856 (2), p. 407), a man, æt. 22 years, took 3 grains; 55 , Dr. Stevens, ibid., a man in the habit of taking 1/8 grain in solution twice a day took more than the usual quantity; 56 , Dr. Bruce, ibid., a man took 4 grains in solid form; 57 , G. M. Jones, Esq., Lancet, 1856 (2), p. 302, Jane D. took 1/2 grain commercial Strych; 58 , Times, February 18th, 1857 (Pharm. Journ., vol. 16, 1856-7, p. 485), William Gummow took 3 grains; 59 , T. W. Craster, Lancet, 1856 (2), p. 107, a woman took 1/4 grain; 60 , R. W. Martyn, ibid., p. 117, a lady, æt. 45 years, took 1/4 grain; 61 , James Campbell, ibid., p. 695, Mrs. M. took an unknown quantity; 62 , same, a man, æt. 30 years, took about 10 grains; 63 , Morse Stewart, M.D., Peninsular Med. Journ., October, 1856, p. 186, a man, æt. 45 years, took a quantity; 64 , same, Mrs. E. A. P. took from 5 to 15 grains in water or ice-cream, death after five hours; 65 , Lewis H. Steiner, M.D., Trans. Am. Med. Assoc., vol. 9, 1856, p. 755; 66 , same, Dr. George A. Gardiner swallowed a paper package containing commercial Strych. or a mixture of Strych and Brucia; 67 , James Kirk, M.D., Med. Times and Gaz., June 14th, 1856, p. 609, a young man took, it was supposed, 6 grains; 68 , Med. Times and Gaz., August 23d, 1856, poisoning of a child; 69 , R. Adams, ibid., Mr. D., æt. 65 years, took 20 grains; 70 , ibid., p. 274, Mrs. Harriet Dove, æt. 28 years, took Strych. in jelly; 71 , S. A. Gus. Shaw, M.D., Am. Journ. of Med. Sci., New Ser., 31, 1856, p. 547, a woman, and a child 2 years old, ate the Sulphate on dried beef; 72 , Tarchini-bonfanti, Gaz. Lomb., 1856 (S. J., 91, p. 300), poisoning of a man, æt. 45 years; 73 , Palmer, Arch. Gen., July, 1856 (ibid.); 74 , Perini, S. J., 91, p. 302, a person took 3 grains; 75 , Gaz. Med. Italian, from Gaz. Méd. de Paris, 1856 (Zeit. für Verein Hom. Aust.), poisoning by an indefinite amount; 76 , Hencke's Zeit. für Staät, 1856 (Zeit. für Verein Hom. Aust.), case of poisoning; 77 and 78 , same, others cases; 79 , Rochester, Am. Journ. of Med. Sci., October, 1856 (Brit. and For. Med.-Chir Rev., January, 1857), a man, æt. 32 years, took 4 grains; 80 , John H. Claiborne, M.D., Virginia Med. and Surg. Journ., 1857, p. 460, a man, æt. 30 years, took a quantity in water; 81 , G. W. Arnett, M.D., Charleston Med. Journ. and Rev., vol. 12, 1857, p. 86, a man, æt. 28 years, took a quantity; 82 , H. O. Jewett, M.D., Bost. Med. and Surg. Journ., vol. 56, 1857, p. 491, a boy æt. 15 years, took probably 2 grains; 83 , Dr. McClintock, Dublin Med. Journ., 1857 (2), p. 215, a boy, æt. 16 years, took 11 grains spread on bread and butter; 84 , H. L. Givins, M.D., Am. Journ. of Med. Sci., 1857 (1), p. 63, a young man took 10 or 12 grains; 85 , George Hodgetts, Pharm. Journ., vol. 16, 1857, p. 389, Mr. M. took 4 grains; 86 , Ernest P. Wilkins, Lancet, 1857 (1), p. 551, Mr. G., æt. 23 years, took 3 grains on a biscuit, death in six hours; 87 , J. R. G., New Orleans Med. News and Hosp. Gaz., 1858, p. 451, Mrs. L. G., an elderly woman, took a large dose; 87 a , same, a few days later took another dose; 88 , J. F. Ogilvie, M.D., Med. Times and Gaz., October, 1858, p. 443, M. C., æt. 21 years, took 4 grains, after drinking largely of pure brandy the previous evening; 89 , Thomas O'Reilly, M.D., Med. Times and Gaz., January, 1858, p. 600, Mr. Johnson took 6 grains in beer; 90 , Douglass A. Reid, Med. Times and Gaz., December, 1859, p. 663, Mr. S. allowed the mouth of a bottle containing Strych. to touch an abrasion of the cuticle of last phalanx of thumb; 91 , Douglass Bly, M.D., New York Med. Journ., 1859 (2), p. 423, a man took 4 grains; 92 , Mr. T. Orton, Pharm. Journ., 1859, p. 245, a girl, æt. 16 years, died from effects of Strych.; 93 , Dr. Davies, ibid., p. 247, Robert. G. Visick died from Strych.; 94 , Dr. S. S. Harris, Am. Med. Times, vol. 1, 1860, p. 100, Thomas W., æt. 28 years, took 6 or 8 grains; 95 , J. B. Dunlap, M.D., Med. and Surg. Rep., 1860, p. 227, Miss S. R., æt. 24 years, swallowed 4 grains; 96 , Pharm. Journ., July, 1860, a girl, æt. 11 years, took Strych., death; 97 , J. R. Smith, Am. Journ. of Med. Sci., New Ser., vol. 40, 1860, p. 278, a man took an unknown quantity; 98 , L. A. Lawrence, Lancet, 1861 (1), p. 571, a woman, æt. 30 years, took an unknown quantity; 99 , George Harley, M.D., ibid., p. 480, W. B. Carleton describes the case of a boy, æt. 12 years, who took 3 grains in a pill, death; 100 , George Harley, M.D., ibid., p. 397, a girl, æt. 11 years, took an unknown quantity of pure Strych.; 101 , Dr. Henrie, Brit. Med. Journ., 1861 (2), p. 400, a child, æt. 4 years, took the powder in preserves, death in half an hour; 102 , Dr. M. Schuppert, New Orleans Med. Times (Med. Times and Gaz., 1861 (1), p. 499), poisoning of a man; 103 , Dr. Langenbeck, Gaz. de Paris, 1861 (S. J., 112, p. 171), 6 milligrams were injected into lachrymal gland, in a man suffering from amaurosis; 104 , Schüler, Gaz. de Paris, No. 6, 1861 (Syden. Year-book, 1861, p. 427), 1/10 grain was introduced, without result, at various times into the eye of a man æt. 50 years, who had suffered from amaurosis, then 1/20 grain was injected into lachrymal canal; 105 , Martius, Memorabilien, 1862, p. 67 (S. J., 131, 235); 106 , Lancet (Brit. Journ. of Hom., vol. 20, 1862, p. 173), poisoning of a woman, æt. 28 years; 107 , J. B. Wilmot, M.D., Med. Times and Gaz., March, 1862, p. 250, poisoning of a girl æt. 18 years; 108 , Blumhardt, Wurt. Corr.-Blatt., vol. 7, No. 1, 1863 (Journ. für Pharm., vol. 4, 199), a boy, æt. 17 years, took about 2 scruples; 109 , Dr. Laukester, Pharm. Journ., 1863, p. 378, George Heimsath, æt. 43 years, drank beer containing Strych., death; 110 , same, Collis drank a small quantity of same, recovery; 111 , W. D. Buck, M.D., Am. Med. Times, vol. 7, 1863, p. 205, Mary Ann Gibney took a quantity of Strych.; 112 , Dr. Frankel, Vjs. für Ger. Med., 1864 (S. J., 131, 235), a man took 5 or 6 grains; 113 , Genets de Serviere, Gaz. Heb. Dom., 1864 (S. J., 131, 235), a woman was poisoned; 114 , same, second case; 115 , Joseph Wilson, M.D., Am. Journ. of Med. Sci., New Ser., 48, 1864, p. 70, a man, æt. 22 years, took probably 40 grains; 116 , George T. Barker, Am. Journ. of Med. Sci., New Ser., 48, 1864, p. 399, poisoning of a woman; 117 , Bertholle, Am. de Hyg., 1865 (S. J., 131, 235), poisoning of a man; 119 , Norman Cheevers, M.D., Indian. Annals of Med. Sci., 1866 (Ranking's Abstract, 1866 (2), p. 225), a girl, æt. 11 years, swallowed an unknown quantity; 120 , Dr. Tracy E. Waller, Phila. Med. Reporter (Pharm. Journ., 1866, p. 533), Dr. --- swallowed 4 grains in water, taking several drinks of whisky before and two afterwards; 121 , S. A. McWilliams, M.D., Chicago Med. Exam., 1866, p. 726, Mrs. T., æt. 31 years, took 5 grains; 122 , Dr. Maschka, Prag. Vjs., 1867 (S. J., 137, 293); 123 , Holmes Coote, Brit. Med. Journ., 1867, p. 513, a woman, æt. 40 years, took 3 minims; 124 , Julian S. Sherman, M.D., Chicago Med. Exam., 1867, p. 138, Charles W., æt. 23, took 2 grains; 125 , omitted; 126 , Stacy Hemenway, M.D., Chicago Med. Exam., 1867, p. 528, James G., æt. 28 years, took a quantity in milk; 127 , Henry Robinson, Month. Hom. Rev., vol. 12, 1868, 252, R. R., æt. 29 years, robust and very healthy, took in all about 7 1/2 grains of Liquor strych. (off. prep.), 20 drops in a tumbler of water, in two doses, one in the morning, one in the evening (first day), 30 drops in three doses (second day), three doses of 12, 15, and 10 drops (third day), four doses of 10 drops each (fourth, fifth, sixth, and seventh days), 48 drops in four doses (thirteenth, fourteenth, and fifteenth days), 60 drops in four doses (sixteenth day), 60 drops in three doses (seventeenth day), 60 drops in four doses (eighteenth to twenty-second day), occasional doses of laxative medicine as required (after twenty-three days), took Camphor and Gum arabic (forty-first day), 1/6 grain of Morphia twice, 20-drop doses of Hyoscyamus, and a large quantity of Linseed tea (forty-sixth day); 128 , same, A. F., a woman, æt. 34 years, very healthy, took 15 drops in a wineglass of water (first day), 20 drops as before (fifth day), 25 as before (eleventh day), 30 as before (fourteenth, seventeenth, twenty-first, twenty-fourth, twenty-seventh, thirty-first, thirty-fourth, and thirty-seventh days), 35 as before (forty-first day), 30 as before (forty-third and forty-seventh days), 445 drops in fifty-three days; 129 , Most's Denkwurdig., 1, 147 (Hom. Exam., vol. 3, 1844), a boy, æt. 4 years, took 4 grains every three hours; 130 , Med. Times and Gaz., 1868 (1), p. 499, poisoning of a child; 131 , James T. Newman, M.D., Med. and Surg. Rep., vol. 20, 1869, p. 234, Miss Kate Pindar took two pills of Strych.; 132 , Tardieu and Roussin, Ann. d'Hyg., 34, p. 128 (Syd. Year-book, 1869-70, 461), a woman survived 15 grains for eighteen hours; 133 , Dr. Keyworth, Glasgow Med. Journ. (Pacific Med. and Surg. Journ., 1869, p. 569) a woman took 3 grains; 134 , James J. Rooker, M.D., Cincinnati Lancet and Obs., vol. 12, 1869, p. 333, poisoning of Mr. A.; 135 , Med. Times and Gaz., 1869 (1), p. 613, poisoning of a man; 136 , Dr. Cameron, Med. Times and Gaz., 1869 (2), 491, M. A. B., æt. 17, took probably 3/4 grain; 137 , J. H. Grimshaw, M.D., Pharm. Journ., Second Ser., vol. 11, 1869-70, p. 45, a child æt. 1 1/2 years, was poisoned by a powder; 138 , omitted; 139 , C. B. Gillespie, M.D., Am. Journ. of Med. Sci., 1870 (2), p. 420, a man swallowed 2 1/2 grains; 140 , W. W. Hewlett, M.D., New York Med. Journ., vol. 13, 1871, p. 297, a man, æt. 30 years, swallowed 5 grains; 141 , Cephas L. Bard, M.D., Phila. Med. Times, June, 1871, p. 316, a man ate cakes made from flour containing Strych.; 142 , Brighton Daily News (Pharm. Journ., Third Ser., vol. 2, p. 16), Mr. Miller ate sweetmeats containing Strych.; 143 , same, S. A. Baker, æt. 4 years, died from effects of eating same; 144 , Thomas Moore, Lancet, 1872 (1), p. 431, a young man took over a grain; 145 , S. Haughton, M.D., Brit. Med. Journ., 1872 (1), p. 660, a man, æt. 19 years, ate an egg in which some Strych. had been placed; 146 , S. A. Turner, M.D., Med. and Surg. Rep., vol. 26, 1872, p. 529, a Sioux Indian, æt. 45 years, took a quantity of Strych. in food; 147 , E. H. Coover, M.D., Med. and Surg. Rep., vol. 26, 1872, p. 520, Mr. E. R. Burke took 1 grain; 147 a , same, account of same as reported by Mr. Burke himself; 148 , Schmid, Memorabilien, 1873 (S. J., 163, 131), poisoning of children; 149 , G. W. Copeland, M.D., Brit. Med. and Surg. Journ., 1873 (2), p. 450, a man swallowed 5 grains; 150 , G. D. O'Farrell, M.D., Phila. Med. Times, February, 1873, p. 311, J. W., æt. 50 years, took 2 grains; 151 , Report of Brooklyn City Hospital, Med. Rec., vol. 9, 1874, p. 345, a person took 5 grains; 152 , Dr. Carbert, Canada Lancet, vol. 7, 1874, p. 10, George Finlayson took 3 1/4 grains; 153 , Dr. C. Bivine, Phila. Med. Times, 1875, p. 720, poisoning of a girl æt. 16 years; 154 , J. B. Sim, Lancet, 1875 (2), p. 310, a woman swallowed 6 drachms Liquor strych.; 155 , J. C. Ogilvie Will, M.D., Edinb. Med. Journ., 1875, p. 907, G. S., æt. 18 years, swallowed not less than 4 grains probably 5 or 6; 156 , W. W. Hays, M.D., Pacific Med. and Surg. Journ., January, 1875, p. 389, a woman took a dose; 157 , H. P. Cole, U. S. Med. Invest., New Ser., 2, 1875, p. 432; 158 , W. F. McNutt, M.D., ibid., November, 1876, p. 251, a middle-aged woman took 14 grains; 159 , Dr. Hippel, Hom. Times, vol. 4, 1877, p. 86, effects of doses of 2 to 4 milligrams; 160 , H. G. Landis, M.D., Phila. Med. Times, October, 1877, p. 6, a man, æt. 29 years, took over 2 grains; 161 , O. G. Shelden, M.D., Med. Rec., vol. 14, 1878, p. 87, A. Manning, æt. 44, somewhat insane, took, it was alleged, between 7 and 8 grains.

MIND

Emotional.
Delirious; she however, possessed sufficient lucidity to state that a certain person had given her a white powder in a glass of wine (after eighteen hours), 132.
She was much like a mad woman all night, 19.
Shouted out, "They are coming for me," 63.
A species of imbecility arising from an excessive acuteness to impressions, 21.
A peculiar nervous erethism, almost resembling what I had seen in a case of hydrophobia several years before. The patient was very much alarmed and excited, slightly delirious, answering questions correctly when asked, but wandering when left to himself, and begged most piteously that I would not hurt him. I was forcibly struck with the very marked resemblance of the delirium in this case to that which I had often seen in mania a potu . The same nervous restlessness and fear of being injured, the same hyperæsthesia and shrinking from currents of air, made the similarity very striking (after seven hours), 161.
Nervous agitated feeling, with sensation of stupor and headache (twenty-first night), 128.
Extreme nervous excitability, ugly face passing before the eyes (twentieth night), 128.
Extreme nervous excitability; she felt light and nonsensical (thirty-seventh day), 128.
Mental condition agitated, but consciousness perfect throughout, 63. [10.]
Excessively nervous and alarmed (after two hours and a half), 36.
Painful nervousness (fiftieth day), 128.
Involuntary idiotic-like chuckle (seventeenth day), 127.
Immoderate fits of laughing (thirty-fourth day), 128.
Fits of laughing, with the light swimming sensation and giddiness (after one hour, forty-first day), 128.
Extreme nervous excitability (forty-first and forty-seventh days), 128.
Screaming, 96.
Loud groans, convulsive sobbing (after fifteen minutes), 167.
Moaning (in fifteen minutes), 52.
Loud moaning (after one hour), 69. [20.]
Constant moaning, with complete consciousness, 77.
Exceedingly low-spirited (eighth day); very low-spirited and gloomy (thirteenth day); low spirits, gloomy, and desponding (twenty-seventh day); extremely low and gloomy (twenty-eighth day); low spirits, gloominess (thirty-fifth day), low spirits, gloomy, and desponding (forty-first day); low-spirited and gloomy (fifty-second night), 128.
Rather morose and wholly uninclined to answer any questions in explanation of his symptoms, 43.
Anxiety, 71 ; (after second powder), 129.
Great anxiety of mind, 21.
Great anxiety and restlessness, 108.
Anxious and agitated, 47.
Excessive anxiety and uneasiness, 4.
General depression of spirits, 65.
A tendency to despondency, 21. [30.]
He had a feeling of dread, and begged he might not be left alone, 56.
A fear of something about to occur, 21.
Great fear, and anxiety for relief, 30.
Mind harassed with dread; he is afraid, and sheds tears all the while; when asked why, replies, "I don't know," 43.
Irritability of temper (forty-third and forty-ninth days), 128.
Short, irritable temper (fifty-fourth day), 128.
Intellectual.
Mind active and anxious, 43.
Muddled, confused feeling, in the morning (seventh day), 128.
Slight confusion of ideas (second day); considerable (after second dose, third day); slight (seventh day), 127.
Confusion of ideas, 132. [40.]
His answers to my inquiries were rapid and unconnected (after three hours and three quarters), 50.
Peculiar muddled vacant feeling, forgetfulness; she felt disposed to sit still and sleep (first day), 128.
Vacant feeling, forgetfulness (second day), 128.
Loss of memory, with a confused giddy feeling, at intervals (thirteenth day), 128.
Loss of memory and drowsiness, with extreme giddiness (seventeenth day), 128.
Feeling of stupor and drowsiness, with the severe pains in the head, at 8 P.M. (second day), 128.
A feeling of stupor and great weariness, with dull pains in the head and eyes (fourth day), 128.
A feeling of extreme stupor, at 10 A.M. (seventh day), 128.
A feeling of extreme stupor (eighth day), 128. [50.]
Feeling of intense stupor (twenty-seventh night), 128.
A feeling of stupor and giddiness (after forty minutes, forty-third day), 128.
Consciousness perfect, till death, 3.
During every violent paroxysm there will be temporary loss of consciousness, accompanied by a cessation of the act of respiration, the wide opening of the eyelids, and extreme dilatation of the pupils, 65.
Unconsciousness, 3, 147.
Stupefaction, with complete loss of consciousness, body stretched out stiff upon the bed, the paroxysm recurring at short intervals, followed by death, 4.
The patient suddenly fell down unconscious, 25.
Insensibility ensued and lasted three hours, although the convulsions hardly ever ceased, 152.

HEAD

Confusion and Vertigo.
Confusion and slight giddiness (twenty-seventh day); confusion and slight giddiness, at noon (twenty-eighth day); confusion and giddiness, with slight trembling (after one hour, thirty-seventh day); muddled feeling in the head (thirty-ninth day); confusion in the head, with feeling of intoxication, at night (forty-first day); confusion and loss memory (forty-third day), 128.
Vertigo, 10, 23, 28 , etc. [60.]
Vertigo and inclination to fall forward (after three to four minutes), 104 ; (after a few minutes), 103.
Vertigo, with roaring in the ears, 3.
Excessive vertigo, even while lying down, associated with nausea, 25.
Great dizziness, 152.
Giddiness and nausea, a sensation as if the brain had been overworked, with great weariness (third day); slight giddiness, at intervals (tenth day); sudden giddiness and extreme drowsiness while walking in the street; she felt as if a cloud was coming over her (after one hour, eleventh day); confused giddy feeling, at intervals, with loss of memory (thirteenth day); giddiness (fourteenth day); giddiness, at intervals (fifteenth day); extreme giddiness, with loss of memory and drowsiness (seventeenth day); giddiness, at intervals, with tremulous feeling, in the afternoon (nineteenth day), extreme giddiness, with a tremulous sensation down the back (after three-quarters of an hour, twenty-first day); extreme giddiness (after three-quarters of an hour, twenty-fourth day); giddy bewildered feeling (twenty-seventh day); extreme giddiness (thirty-first day); extreme giddiness, with fixed stiff sensation in the eyes (after half an hour, thirty-fourth day); giddiness; light swimming sensation, with fits of laughing (after one hour, forty-first day); sudden momentary giddiness, with dull pains in the head and eyes, at noon (forty-second day); a feeling of giddiness and stupor (after forty minutes, forty-third day); giddiness; light swimming sensation in the head (after three-quarters of an hour, forty-seventh day); extreme giddiness; light swimming sensation in the head (two hours after first dose, fiftieth day), 128.
Extreme giddiness and confusion in the head (after half an hour, fifty-third day), 129.
General Head.
Jerking of the head forwards (twenty-fourth day), 128.
Head jerked backwards, 154.
Head drawn backward, 76.
Veins of the head, neck, and face became highly turgid, 152. [70.]
Violent congestion of the head, so that the face looked bluish-black, with very red protruding eyes, 22.
A feeling of weariness in the brain; she felt a great desire to lie down and sleep (fourth day), 128.
Dull pains in the head and eyes, with a feeling of stupor and great weariness (fourth day), 128.
Dull pains in the head and eyes (forty-third day), 128.
Slight dull pain in the head, behind the right ear (after two hours, fifth day), 128.
Headache, 9, 29.
Violent headache, with bursting pains in the forehead, especially the left side, at 10 A.M. (eighth and ninth days), 128.
Stupid headache, with extreme drowsiness (fifteenth day), 128.
Violent bursting headache, with stiff contracted feeling in the eyes, in the morning (sixteenth day), 128.
A feeling as if a bad headache was coming on, with extreme fulness of the head and ears, in the afternoon (twenty-second day), 128. [80.]
Slight headache, with dull pains in the forehead and eyes, in the morning (twenty-third day), 128.
Distressing headache, in the morning (forty-third day), 128.
Slight headache (forty-seventh day), 128.
Headache, with pains in the eyes (fifty-second day), 128.
Constant headache, sleeplessness, and slight fever, caused by nervous apprehension and dread of the rectal spasms, which came on very suddenly, and without previous warning, 127.
Headache coming on suddenly, especially in the left half of the head and left eye, at 4 P.M. (third day), 128.
On rising in the morning, severe headache, a sensation as if the head would burst when stooping (second day), 128.
Severe pains in the head, generally in the left eye and behind the ears, with a feeling of stupor and drowsiness, at 8 P.M. (second day), 126.
Violent pains through the head, from the back to the front (eleventh day), 128.
Violent pains in the head, especially in the forehead and over the left eye, in the morning (thirty-third day), 128. [90.]
Violent pains in the head and muscles of back of neck, in the morning (thirty-fourth day), 128.
Violent pains in the head and eyes (forty-first day), 128.
Momentary darting pains, in the head and under the jaw, left side (third day), 128.
Severe darting pains, in the head and back of the neck (eleventh day), 128.
Sharp pains flying about the head; at times a fixed pain at the vertex (second day), 128.
Sensation as if an iron cap was on the head (twenty-fourth day), 128.
Racking pains seized her whole head, 19.
Violent thumping pains, in the head, especially the right half, and over the left eye, lasting about two hours, in the evening (nineteenth day), 128.
Shattered sensation, in the head, with drowsiness (thirty-third day), 128.
Darting pains, in the head and eyes (fifty-third night), 128. [100.]
Convulsive jerkings and shocks transversely through the hemispheres of the brain, associated with pain extending into the eye, 29.
Feeling of a cold in the head, in the evening (thirty-fifth day), 128.
Felt strange sensation in head (after twenty minutes), 30.
Throbbing pain in head; less pain about the forehead than in any other part of his head, 43.
Forehead.
Headache, especially in the forehead and eyes (twenty-ninth day), 128.
Headache, in forehead and eyes, in the morning (thirtieth day), 123.
Temples.
Sharp darting pains in the left temple and round to back of left ear (sixth day), 128.
Rapid pulsation in left temple and in left hypochondrium, in the morning (fortieth day), 128.
Vertex and Parietals.
Sudden pain and pressure at the top of the head and in the left eye (twelfth day), 128.
Peculiar paralyzed feeling in the left half of the head and face (seventh day), 128.
Occiput. [110.]
Dull pains in back of head and temples (fifteenth day), 128.
Feeling of pressure in the back of the brain, with nausea, at noon (thirty-fifth day), 128.
Constant pain in the back of head and nape of neck, lasting the whole day (thirty-fifth day), 128.
Boring pain in the occiput, 3.
Pains in the back of the head, extending down the entire length of the spine (seventh day), 128.
Sharp pains in the back of the head, extending to the left eye, and to the back of the right ear (eighth day), 128.
Sharp pains in the back of the head and in the glands of the neck (seventeenth day), 128.
Darting pains in back and top of head (forty-first day), 128.
Sharp darting pains in back of head and neck, in the afternoon (fifty-second day), 128.
External Head.
Sore pains in the scalp, as if the hair had been pulled (twelfth day), 128. [120.]
Intense itching of scalp and nape of neck (thirty-sixth day), 128.

EYE

Objective.
Eyes highly injected, and in constant motion, as from seemingly great affright, as, indeed, his mind fully evidenced (after three hours and three-quarters), 50.
Eyes injected, and protruding, 82.
Eyes a little suffused, 63.
Eyes sunken, 6, 24.
Eyes sunken, and moved with a rapid motion, 89.
Rolling of the eyes, as if they were two cold bullets (twenty-fourth day), 128.
Torsion of the eyes (after second powder), 128.
Eyes turned to one side, quite staring, 78.
The eyes were drawn upward and greatly congested, 147. [130.]
The eyes appeared to be starting from their sockets, the head was forcibly drawn round, the arms and legs horribly convulsed, she being conscious at the same time, 60.
Protruding eyes, 3, 4, 47, 62.
Eyes staring, 158.
Eyes protruding, turned towards the right, and fixed, with dilated, insensible pupils, and red conjunctiva, 108.
Eyes protruding, rigid, turned to the right, 4.
Eyes fixed, and turned upwards, 30.
Dimness of the eyes (third and fifty-fifth days), 128.
Dimness and aching of the eyes (thirty-fourth day), 128.
Subjective.
Dull pains in eyes and head (forty-third day), 128.
Aching and smarting of the eyes, in the afternoon (thirty-sixth day), 128. [140.]
Aching of the eyes, with dull misty vision (forty-third day), 128.
Severe pain in the left eye, at 8 P.M. (second day), 128.
Sudden pain and pressure in the left eye and at the top of the head (twelfth day), 128.
Violent pains in left eye (thirty-fifth day), 128.
Boring sensation in the eyes, especially the left eye (forty-third day), 128.
Weight in the eyes, with sharp pains in the left half of the head, and in the left eye (seventh day), 128.
A feeling as if the eyes were suddenly stiffened and drawn back, lasting a few minutes (seventh day), 128.
Stiff sensation in the eyes; she felt unable to look up (seventh day), 128.
Stiff contracted feeling in the eyes, with violent bursting headache, in the morning (sixteenth day), 128.
Fixed stiff sensation in the eyes, with extreme giddiness (after half an hour, thirty-fourth day), 128. [150.]
Heavy stiff sensation in the eyes (thirty-sixth day), 128.
Stiff fixed sensation in the eyes, with burning and itching (forty-first day), 128.
Stiffness of the eyes, with burning and itching (forty-third day), 128.
Fixed feeling in the eyes (fiftieth day), 128.
Stiffness of the eyes, with stinging and smarting (fifty-third day), 128.
Burning in left eye and left ear, in the afternoon (second day), 128.
Eyes very hot and painful (ninth day), 128.
Burning heat in the eyes (eleventh day), 128.
Burning heat in the eyes and eyelids (twelfth day), 128.
Hot fixed sensation in the eyes (fourteenth day), 128. [160.]
Burning heat in the eyes (sixteenth day), 128.
Intense burning of the eyes (twenty-first night), 128.
Intense burning of eyes and ears, at night (forty-seventh day), 128.
Sudden burning and itching of eyes, (fifty-third day), 128.
A feeling as of a cold in the eyes, at night (forty-eighth day), 128.
Orbit.
Tender, bruised feeling over the left eye, with fixed pain, toward evening (ninth day), 128.
Rapid pulsation over left eye (fiftieth and fifty-second night), 128.
Lids.
Eyes widely opened, 130.
The eyelids are closed, as though to shield the eyes from an intense glare of light, 63.
Eyelids closed all the time, as though the light was intolerable; in fact, the lids were only separated during the convulsions, and then the pupils were widely dilated, 66. [170.]
Keeps his eyes always shut (after twelve hours), 43.
Violent rapid pulsation in the left upper eyelid, with weakness and watery discharge from the eye, lasting for eight hours (thirty-second day), 128.
Rapid pulsation in the left upper eyelid, lasting for several hours (thirty-first day), 128.
Lachrymation.
Increased lachrymation, 29.
Conjunctiva.
Conjunctiva injected, 4.
Ball.
Aching of the eyeballs (twenty-seventh night), 128.
Sharp, sore pains in balls of eyes, in the evening (sixteenth day), 128.
Sharp needlelike pains in the balls of the eyes (twenty-seventh day), 128.
Sharp pains in the balls of the eyes (twenty-eighth day), 128.
Pupil.
Pupils slightly dilated, 47. [180.]
Pupils dilated, 30, 67, 78.
Pupils greatly dilated, 3, 121, 148.
The pupil was somewhat dilated and the eye staring, its motion tremulous and both orbs constantly oscillating in their orbits, like the eyes of the albino; there was no suffusion, however, throughout, 64.
Pupils dilated to their fullest extent; the eyeballs appeared to be protruding out of their sockets, 68.
Pupils dilated during the spasms, 100, 136.
Pupils dilated and insensible, 4.
Pupils, at one time dilated, at another contracted, 13, 16.
Pupils contracted, 14, 50.
Contracted pupils, during paroxysms, pupils dilated, 145.
Pupils about natural, or, if anyway abnormal, rather contracted, 63.
Vision. [190.]
Dimness of vision (after twenty minutes), 42 ; (thirty-sixth day), 128.
Sense of sight became much impaired (soon), 146.
Confused misty vision (thirty-ninth day), 128.
Persistent amaurosis, 18.
Numerous sparks before the eyes, sometimes blackish, sometimes white, sometimes red, 17.
1st. Increased peripheric sensibility for blue. 2d. Temporary increase of visual power. 3d. More distinct perception of peripheric points. 4th. Lasting enlargement of the field of vision, 159.

EAR

Creeping tingling sensation in the external ears (second day), 128.
Sudden burning and itching of ears, eyes, and nose (fifty-third day), 128.
Burning in the left ear and left eye, in the afternoon (second day), 128.
Sudden burning heat in the left ear, and along the lower jaw of same side, at 10 P.M. (eighth day), 128. [200.]
Intense burning of and bruised feeling in the ears (twenty-second day), 128.
Intense burning and itching of the ears, nose, and eyes (twenty-fourth night), 128.
Burning and tingling in the ears nose, and lips, at noon (twenty-fifth day), 128.
Intense aching behind the ears and down the spine (twenty-fourth day), 128.
Sharp darting pains behind the right ear (twentieth day), 126.
Sharp darting pains in and behind the ears, and back of the head and neck (thirty-sixth day), 128.
Cracking in the ear and jaw; it is very painful to move the jaw, as in clenching the teeth (forty-fifth day), 128.
Digging pains deep in the left ear (eighth day), 128.
A feeling of intense fulness in the ears (second day), 128.
Hearing.
The ears become appreciative of the slightest sound in the room, 65. [210.]
Hearing very acute, and remarks made in a very low tone of voice were replied to quickly, 66.
Roaring in the ears, 29.
Noise in the left ear like wind (seventh day), 128.
Humming in the ears (twenty-third day), 127.

NOSE

Frequent fits of sneezing, with itching and stinging of nose (forty-seventh day), 128.
Peculiar stinging in the nostrils, as if a cold were coming on (thirteenth day), 128.
Burning and tingling in the nose, ears, and lips, at noon (twenty-fifth day), 128.
Sudden burning and itching of nose (fifty-third day), 128.
Intense itching of the nose, as if in the bone, lasting the entire day (second day), 128.
Intense itching and stinging of the nose (thirty-fourth night), 128.

FACE. [220.]

Face swollen and burning hot; I was exceeding surprised at the appearance she presented, in the morning, her eyes were half closed with swelling, and I could only compare them with those of a person stung by bees; but the next evening everything looked favorable, with a decided abatement of the swelling and pain, 19.
Face puffy, covered with perspiration, 75.
Face puffy and red, 76.
Face puffy, pale, distorted, 4.
Face puffy and bluish red, with open mouth, 2, 3.
Face puffy, dark-violet colored, lips dark blue, 4.
The muscles of the face and about the mouth became rigid and drawn, as in risus sardonicus, it became impossible to utter articulate sounds, 108.
Hard stiffness of the muscles of the face (sixth day), 128.
Hard rigidity of the muscles of the face (thirty-fourth day), 128.
Contorted countenance, 62, 42. [230.]
Expression of extreme terror, 49.
Expression of extreme sadness and despondency, 43.
Anxious expression of countenance, 63, 119, 126, 130.
Countenance expressive of intense anxiety and distress, 64.
Countenance extremely anxious (after one hour), 124.
Expression indicative of great suffering, 158.
Expression of countenance hideous (after six hours), 150.
Face exhibiting an almost maniacal expression, 40.
Wild look with dilated pupils and red face, 28.
Face became gradually pale, from above downwards, lips remaining livid, 30. [240.]
Pale sunken look, 62.
Face deathly pale, 6, 24.
Face pale, anxious, 122, 145.
Face pale and distorted, 108.
Countenance pale and blue (after three to four minutes), 104.
Face somewhat flushed (between the spasms), 68.
Face flushed, 121, 135.
Face suffused and red, 131.
Face much flushed (after twenty minutes), 20.
During the day, flushing and heat of face (second day), 127. [250.]
Face flushed and bathed with cold and clammy perspiration (after three hours and three-quarters), 50.
Countenance suffused and livid, 82.
Face livid, 132, 133, 158.
During the spasms, the countenance, and in the last and fatal convulsion, it suddenly became almost black, 100.
Face of livid red and covered with profuse sweat, 89.
Features livid, congested, 88.
Face blue, 148.
Face bluish red, 23.
Face of a dusky hue (after one hour), 34.
Face of a dark-purple hue, 154. [260.]
Face and hands livid, 47.
Purple color of the face (after two powders), 129.
Face began to become black (immediately), 143.
Tremulous feeling in the muscles of the face (seventh day), 128.
Cheek.
Sharp needlelike pains in the cheek-bones and under the jaw, left side (thirteenth day), 128.
Keen sharp pain in the left cheek-bone, shooting to the upper teeth (twenty-second day), 128.
Lips.
He was making constant motions with his lips as though he desired drink (after three hours and three-quarters), 50.
Lips retracted, 141.
Lips blue, 9.
Lips livid (after twenty-minutes), 30. [270.]
Lips livid and retracted, 130.
Lips and tongue purple, 158.
Lips tumid, 88.
Burning and tingling in the lips, nose, and ears, at noon (twenty-fifth day), 128.
Chin.
Jaw partially set, and the handling caused an abortive convulsion, 150.
Trismus, 4, 8, 47 , etc.
Lower jaw spasmodically closed, 75.
The muscles of the jaws remained so rigid between the spasms as to prevent their being opened sufficiently to admit the tube of stomach-pump being introduced, 40.
Jaws locked and deglutition impossible, with foaming at the mouth similar to that observed in patients suffering from hydrophobia, 147.
Trismus and constriction of the throat on swallowing, 149. [280.]
Periodic attacks of trismus, 108.
Considerable stiffness of muscles of mastication, and difficulty in opening and shutting mouth (second day); slight stiffness of muscles of jaws and hands (fourth day), 127.
Stiffening of the jaws and neck (fourteenth day), 128.
The jaws were suddenly stiffened for a few minutes, and then in a moment became relaxed (fifth day); stiffening of the jaws (seventeenth day); stiffening of the jaws, and afterwards of the muscles of the face and hands (twenty-first day); stiffening of the jaws and muscles of the face and neck (twenty-fourth day); stiffening of the jaws and muscles of the face and neck (twenty-seventh day); stiffness of the jaws and muscles of the face (thirty-fourth day); slight stiffening of the jaws (thirty-seventh day); stiffening of the jaws and muscles of the face (forty-first day); stiffening of the jaws (forty-third day); momentary stiffness of jaws (forty-seventh day); stiffening of the jaws, muscles of face, and throat (fiftieth day); stiffening of jaws, affecting the speech (fifty-third day), 128.
Stiffening sensation in the jaws (sixth day); stiffening heavy sensation in the jaws and muscles of the face (eleventh day); stiff tight sensation in left articulation of jaw, with much pain at times; also a similar feeling in muscles of neck and down the spine (forty-eighth day); tight feeling in jaws, with hard rigidity of the muscles (fiftieth night), 128.
Pains in the articulation of the jaws and muscles of the back of the neck (twelfth day), 128.
Pains in the articulation of the jaws and in the back teeth (thirteenth day), 128.
Dull pains in the articulation of the jaws, shooting into the temples, in the evening (twentieth day), 128.
Dull aching and stiff sensation in the jaw and muscles of neck, in the afternoon (forty-fifth day), 128.
Dull aching in articulation of jaw, with tight sensation about the jaw and ear, in the morning (forty-sixth day), 128.
Rheumatic-like pains, especially in the articulation of the jaws and extensors of thighs (nineteenth day), 127.
Severe tearing pains in the articulation of the jaws, with sore stiffness in the muscles of the face and nerves of the teeth (thirty-sixth day), 128. [290.]
Sharp pain in articulation of jaws and in the muscles of neck, left side, at noon (forty-fifth day), 128.
Sharp needlelike pains under the jaw, left side (fifteenth day), 128.
Sharp needlelike pains in lower jaw, left side (twenty-eighth day), 128.
Tremulous sensation in the jaws, with peculiar creeping chilliness all over (third day), 128.
Shooting pains under the jaws and in the muscles of the chest, left side (second day), 128.
Sharp needlelike pains under the jaws, especially the left side, at 8 P.M. (twelfth day), 128.
Peculiar pulsation in the chin, as if in the nerves of the lower front teeth, at short intervals (forty-second day), 128.
Pulsation in the chin (forty-third and forty-ninth day), 128.

MOUTH

Teeth.
Clenching of the teeth, with twisted sensation in the jaws (forty-first day), 128.
Severe toothache, at midnight (third day), 128. [300.]
Violent attack of toothache in the upper teeth, left side, shooting to the cheek-bone (twenty-third day), 128.
Sharp attack of toothache in left half of the teeth (twenty-sixth night), 128.
Toothache in the upper teeth at intervals, a sensation as if the teeth were loose and too long (thirty-second day), 128.
Toothache in the upper teeth at intervals, they feel too long (thirty-third day), 128.
Sharp attacks of toothache, worse in the right upper teeth, coming on at intervals, at night (thirty-fourth day), 128.
Severe pains in the teeth, as if the nerves were suddenly pulled out, at night (thirty-fourth day), 128.
Sharp pains in nerves of teeth, in the evening (thirty-eighth day), 128.
Sharp pains in the nerves of the teeth (forty-fourth night), 128.
Drawing toothache in left upper teeth (fiftieth day), 128.
Violent shooting pains in upper teeth (thirty-fifth day), 128. [310.]
Sharp pains in the back teeth and jaws (fourth day), 128.
Sharp pains in the back teeth and in the articulation of the jaws (fifteenth day), 128.
Pains in the back teeth and articulation of jaws (nineteenth day), 128.
Tongue.
Tongue, gums, and lips violet, 12.
Tongue dry and papillæ erect, 49.
Tongue dry with white moisture on the edges, 26.
Tongue much coated, bad taste (seventh day), 178.
Tongue coated, bad taste (twenty-ninth day), 128.
Tongue felt hot (after thirty minutes), 123.
Soreness of the tongue and roof of the mouth (thirteenth day), 128.
General Mouth. [320.]
Mouth distorted, 76.
The mouth was closed, but apparently not as rigidly as in tetanus, for the will could control it to a certain degree; yet as it seemed, they fearing exciting uncontrollable spasms by any motion of the jaws, its muscles were held tense and tight, 64.
Frothing from the mouth, 22.
Violent itching in the roof of the mouth (thirty-fourth day), 128.
Taste.
Bad taste (several days), 128.
Feverish taste (several days), 128.
Hot and bitter taste in the mouth and fauces (after one hour and three-quarters), 136.
Very bitter taste in the mouth constantly, 43.
Dry taste in the mouth, 145.
Saliva.
Flow of saliva, 32. [330.]
It caused a great quantity of saliva to flow, and she shook her head, seemingly much disgusted, 31.
Excessive spitting of frothy saliva (after twelve hours), 126.
Mouth filled with frothy saliva (after one hour), 124.
Teeth covered with frothy saliva, 141.
Mouth covered with saliva, which ejected by spasmodic jerks, 89.
Speech.
Difficult to articulate with distinctness, in the interval between the spasms, 34.
Articulation difficult (after twenty minutes), 39.
Articulation extremely difficult (after twenty minutes), 42.
Speech indistinct, 24.
Unable to speak, muttered only unintelligible sounds, which seemed to correspond to the rhythmical movements of the lips, which, however, were soft and mobile, and moved as though he wished to speak, 6. [340.]
Complete loss of speech (after a few minutes), 103.
Speechless but conscious, 133.

THROAT

Choking sensation in the throat, 71.
Dreadful sensation of choking, 57.
Choking sensation, as if something were tied round the throat tightly (seventeenth day), 128.
Most uncomfortable sensation about the throat and head and slight spasms of the muscles, 38.
Sensation of spasm in the throat and stomach, associated with ineffectual efforts to vomit, 72.
Stiffness about throat, 145.
Constriction of the throat and tightness of the chest, with rigidity of the muscles on attempting to move (after five minutes), 34.
There seemed to be some constriction about the throat, as it was difficult for him to swallow, 34. [350.]
Constriction of the muscles of the throat and larynx, 80.
Contraction of throat (after five minutes), 33.
A feeling of contraction in the throat, left side, shortly after rising in the morning (sixth day), 128.
Spasmodic feeling of contraction in the throat (eighteenth day), 128.
Contraction of the throat, with intense difficulty of swallowing (twenty-seventh day), 128.
Suddenly a sense of contraction in the throat; a feeling as if something were constantly rising in the throat, with sickness, in the afternoon (forty-eighth day), 128.
Feeling as of a lump in the throat, in the evening (thirty-sixth day), 128.
Painful dryness and contracted feeling in the throat (eleventh day), 128.
Painful dryness of the throat (twelfth day), 128.
Dry contracted feeling in the throat (fifteenth day), 128. [360.]
Dry contracted feeling in the throat, in the morning (forty-ninth day), 128.
Hot pains and dry sensation in the throat, coming on at intervals and lasting a short time (second day), 128.
Dry hot feeling in the throat (third day), 128.
On rising in the morning, a slight sensation of a sore throat, left side, with a general dry heat in the throat (fourth day), 128.
Soreness in the left half of the throat (seventh day), 128.
The throat begins to feel much worse; hot pains shooting from the left side of the throat into the ear and eye, at 8 P.M. (seventh and eighth days), 128.
Throat painful and sore, with redness and slight swelling (eighth day), 128.
Throat sore and painful the entire day (ninth day), 128.
Scraping in the throat, 29.
Spasmodic pains in throat and chest, with sick faint feeling, in the evening (fifty-fourth day), 128. [370.]
Burning and suffocating sensation about throat and chest, 119.
Fauces.
Sense of constriction in the fauces, and at times could only swallow with difficulty (after one hour), 124.
Constriction of fauces with difficulty of swallowing (after twelve hours), 126.
Swallowing.
Deglutition almost impossible, 141.
Every attempt at deglutition produced violent spasms of the muscles of the pharynx, 152.
Swallowing with some difficulty, 43.
He swallowed with difficulty, even in the intervals of the most complete remission of the convulsions, 80.
External Throat.
Severe dull pains in the muscles and glands of the neck, and at times shooting up into the head (thirteenth day), 128.
Dull shooting pains in the glands of the neck, and at the back of the ears (second day), 128.
Dull pains in the glands of the neck and behind the ears (third day), 128. [380.]
Sharp pains in the glands of the neck and in the back of the head (seventeenth day), 123.

STOMACH

Appetite and Thirst.
Unusually good appetite, she enjoys her food amazingly (third day), 128.
Feverish thirst (sixteenth day), 128.
She asked for drink, 57.
Great thirst, 49.
Intense thirst, dry mouth and tongue, 43.
Eructations.
Eructations of bitter wind before vomiting, 43.
Eructations of tasteless wind, 43.
Bitter greasy risings, with bad taste (fourteenth day), 128.
Nausea and Vomiting.
Nausea, 43 ; (sixteenth day), 128. [390.]
At times felt great nausea (ninth day), 128.
Nausea and bad taste (twenty-first night), 128.
Nausea and bad taste, in the forenoon (twenty-seventh day), 128.
Nausea, with a feeling of pressure in the back of the brain, at noon (thirty-fifth day), 128.
Tendency to nausea, actual vomiting being only kept off by constant spitting (forty-fifth day), 127.
Nausea and vomiting (after first powder), 129.
Almost constant retching, 87.
Frequent effort to vomit, 73.
Vomiting, 62, 110, 121, 126.
Violent vomiting, 5. [400.]
Immediately became violently ill and cried and screamed in a most alarming manner, 143.
At times vomiting of thin colorless liquid, 23.
The chamber vessel contained about a pint of coffee-colored fluid, mixed with a more solid brown material, the whole supposed from its odor to have been vomited, and to contain most of the Strychnia (having drank coffee at supper), 113.
Vomited small quantities of some alcoholic fluid, 132.
Stomach.
The digestive functions were somewhat disordered, 127.
Heavy feeling in the stomach, 43.
There appeared to be much pain in the epigastrium, 132.
Intense pain in the stomach and bowels, 87.
Intense pain in pit of stomach (after six hours), 130.
Complained of pain at the pit of the stomach, 67. [410.]
At intervals, deep pains at the pit of the stomach (tenth day), 128.
Spasmodic pain about the pit of the stomach, extending to the heart at intervals, in the afternoon (twelfth day), 128.
Sharp pains at the pit of the stomach, extending round to region of liver (fourteenth day), 128.
A kind of internal twitching and nervous feeling radiating as it were from the pit of the stomach (sixteenth day), 128.
Sharp pains at the pit of the stomach (seventeenth and forty-eighth day), 128.
Jerking sensation in the stomach, when opening the mouth (thirty-seventh day), 128.
Violent jerks at the pit of the stomach and in the chest, on attempting to open the mouth (forty-first day), 128.
Sudden jerks in the stomach, (forty-third day), 128.
Violent attack of spasm at the pit of the stomach, coming on suddenly while at dinner and lasting about an hour; it was attended with very severe pain and feeling of suffocation, so much so that she had to unloose her clothes, in the afternoon (thirty-third day), 128.
Spasms of diaphragm very marked (after twenty minutes), 30. [420.]
Heat in the stomach, 71.
Burning along the œsophagus and in the stomach, 80.
Sense of burning about the stomach (after twenty-minutes), 42.
Burning pains at pit of stomach, at noon (forty-ninth day), 128.
Sensation of burning in stomach, 87.
Immediately felt a burning sensation in the stomach for about a minute, and then felt as if his blood grew cold, 121.
At times, hot pains at pit of stomach (fifty-second day), 128.

ABDOMEN

Hypochondria.
Peculiar aching sensation in the right hypochondrium, at intervals, with sick, faint feeling (forty-third day), 128.
Tense pain in right hypochondrium (first night), 127.
Sharp cutting pains in left hypochondrium (twelfth day), 128. [430.]
Sharp pains right hypochondrium (twenty-seventh day), 128.
Keen, needlelike pains in the right hypochondrium, at the pit of the stomach, and also at intervals in the right knee-joint (thirtieth day), 128.
Sharp pains in left hypochondrium, at times, shooting to the pit of stomach, in the morning (nineteenth day), 128.
Rapid pulsation in left hypochondrium and left temple, in the morning (fortieth day), 128.
General Abdomen.
Abdominal muscles and those of neck and back in a state of tetanic spasm, 145.
Bowels much distended, 143.
Distressing flatulence, (twenty-ninth, thirty-sixth, and forty-eighth days), 128.
Distressing flatulence with sick feeling, at night (thirty-fourth day), 128.
Rumbling in the bowels, with a feeling of diarrhœa; also deep pains in the abdomen generally, at 7 P.M. (eleventh day), 128. [440.]
Rumbling in the bowels, with feeling of threatening diarrhœa, in the forenoon (eighteenth day), 128.
Sore, contracted feeling in the muscles of the abdomen generally (after one hour and three-quarters), 128.
Sore, contracted feeling in the muscles of the abdomen, especially the upper half (twenty-seventh day), 128.
Sore, bruised sensation in the muscles of the abdomen (twenty-eighth day), 128.
Painful soreness of muscles of upper half of abdomen, with sick feeling (thirty-seventh day), 128.
Painful soreness of the muscles of the abdomen, upper half, and at the pit of the stomach (forty-third day), 128.
Deep, sore pains in the muscles of upper half of abdomen (forty-first day), 128.
Severe, sharp pains in the muscles of the abdomen (fifth day), 128.
She seized her abdomen as if to tear it, such was the intense pain there, 116.
Griping pains in the bowels (second day), 128. [450.]
Momentary griping pains in the bowels (third day), 128.
Griping pains in the bowels and constipation (fourth day), 128.
Griping pains in the bowels, with feeling of diarrhœa, in the morning (twenty-second day), 126.
Griping pain in the bowels, at daybreak (twenty-seventh day), 128.
Griping pains in the bowels, with feeling as of diarrhœa (thirty-ninth day), 128.
Griping pains in the bowels, with feeling of diarrhœa (forty-third day), 126.
Griping pains in the bowels, with feeling of diarrhœa, in the morning (fifty-fourth day), 128.
Intense aching round the waist, in the morning (fifty-first day), 128.
Pressing down in the bowels, 43.
Pains in abdomen (after two hours), 140. [460.]
Sore pains in the bowels, with a sensation of threatening diarrhœa (sixteenth day), 128.
Sore pain in upper half of abdomen (thirty-eighth day), 128.
Deep, sore pain in abdomen, especially the lower half, at noon (fifty-fifth day), 128.
Deep pains in the abdomen, at intervals, generally beginning at the lower half and afterwards going upwards (thirteenth day), 128.
Deep, bruised sensation in the abdomen, from the groins over the hips and across the back, with external tenderness, in the morning (thirty-second day), 128.
Dull gnawing pains in abdomen and pit of stomach, in the morning (fifty-fourth day), 128.
Sharp cutting kind of pains in the right lower half and left upper half of abdomen (third day), 128.
Violent cutting pains in the bowels, with feeling of diarrhœa, in the morning (twenty-ninth day), 128.
Sharp cutting pains in the bowels, with feeling of diarrhœa (forty-fourth night), 128.
Severe cutting pains in the bowels, in the morning (forty-fifth day), 128. [470.]
Uneasiness in the bowels, with constipation (twenty-fifth and twenty-sixth days), 128.
Warmth in the bowels, 43.
Hypogastrium and Iliac Regions.
Fixed, deepseated pains in the lower half of the abdomen (first day), 128.
Deep pain in the left lower half of the abdomen, coming on at intervals during the day; also occasionally the same kind of pains at the pit of the stomach (tenth day), 128.
At times spasmodic pain in the lower abdomen, in the afternoon (twelfth day), 128.
Violent cramplike pain in lower right half of abdomen (nineteenth night); in the morning the same kind of pain in the abdomen as during the night; in addition, severe cutting pains in the bowels, with a feeling of diarrhœa coming on (twentieth day), 128.
Deep-boring pains in the right lower half of abdomen, changing suddenly from one part to another (fifteenth day), 128.
Deep, sore, contracted feeling in the left lower half of abdomen (twenty-fifth day), 128.
Deep aching pains in the lower half of abdomen, right and left sides, passing through to the back, with aching over the hips (thirty-first day), 128.
Dull sore pain in lower half of abdomen, followed by a peculiar momentary pressure in left iliac region (forty-fourth night), 128. [480.]
Deep sore pains in lower half of abdomen (fortieth day), 128.
Deep painful soreness in lower half of abdomen (forty-second day), 128.
Deep cramplike pain in the lower left half of abdomen, at night (forty-sixth day), 128.
Deep boring pain in lower half of abdomen (forty-ninth day), 128.
Sharp cramplike pain in lower half of abdomen, in the morning (forty-eighth day), 128.
Deep sore pain in lower half of abdomen (fifty-fourth day), 128.
Burning pains in lower half of abdomen, at intervals (fifty-third day), 128.
Sharp needlelike pains in the left groin, lasting a few minutes (forty-seventh day), 128.

RECTUM AND ANUS

Gurgling sounds in the rectum, with sudden darting pains of greater or less severity. Some few days afterwards the symptoms in the rectum became much more marked; there was a constant gurgling sound, as if a considerable amount of fluid was there, in closed in a loose sac; the spasms of darting pain became more frequent, and were sometimes so unbearable as to force him down on the ground as if shot, 127 . [Sulphur 30 in globules, taken dry on the tongue three times a day, brought about rapid and almost complete relief of all the rectal symptoms.]
During the night, two most agonizing darts of pain in the rectum (forty-fifth day), 127. [490.]
Before going to bed, two darts of pain in the rectum, resembling shocks from a strong galvanic battery (forty-seventh day); excruciating pains in the rectum, of the same character as before (forty-eighth day), 127.
Slight twinges of pain in the rectum (fiftieth and fifty-first days), 127.
Spasmodic jumping in the anus, at night (fifth day), 128.

STOOL

Diarrhœa.
Copious watery diarrhœa, 89.
Purged copiously during the night, 50.
Sharp attack of diarrhœa (twenty-seventh day), 128.
Fæces discharged involuntarily during the spasms, 49.
The dejections lumpy and dry, the flatus having a smell as of fresh putty; dejections afterwards lumpy and accompanied by mucus, 127.
Constipation.
Very obstinate constipation, 33.
Constipation and griping pains in the bowels (fourth day), 128. [500.]
Large doses of cathartics were at first necessary to procure a movement of the bowels, and the black draught seemed to do better than any other form of cathartic, 161.

URINARY ORGANS

Bladder and Urethra.
The bladder seemed to participate in the general contraction of the voluntary muscles, and expelled small quantities of urine as fast apparently as it flowed into the viscus, 44.
After about ten days, perfect paralysis of the coats of the urinary bladder came on, and the regular use of the catheter was necessary for about two weeks, when the normal function of the bladder was gradually restored, 161.
Painful pressure in the bladder and rectum, 103.
Uneasiness about the bladder and urethra, at first slight, but daily increasing, aggravated by walking or sitting on anything hard (thirty-first to fortieth day), 127.
Occasional darting pains from the bladder down the thighs (thirty-first to fortieth day), 127.
Shooting pains about the neck of the bladder and down the rectum forty-fourth day), 127.
Shooting pains down the front wall of the bladder, and thence along the urethra (forty-first day), 127.
Unable to leave the house on account of the burning pain caused in the urethra by walking (forty-first day), 127.
On the forty-fourth day the pains left the bladder and settled in the glans, where they became constant and very severe, 127. [510.]
Renewal of scalding pain in the urethra (forty-seventh day), 127.
Occasional scalding pains in the urethra (fiftieth and fifty-first days), 127.
Micturition and Urine.
Constant urging to make water, the urgency not being removed by the act (thirty-first to forty-first day), 127.
No rest at night, being continually obliged to rise and attempt to make water (thirty-first to fortieth day), 127.
Very copious secretion of urine, 3.
Passes some urine under her, 132.
Urine scanty, with constant urging (twenty-fifth day), 128.
Urine very variable in character, sometimes natural in appearance, sometimes as dark as bad table-beer, sometimes with a thick red sediment, and sometimes with albuminous-looking masses floating in it (forty-fourth day), 127.

SEXUAL ORGANS

Male.
Left spermatic cord painful and the testicle swelled (forty-fifth day); testicle still swelled and painful (forty-sixth and forty-ninth days); testicle remains as before, swelled, but causing no pain, except in standing up or walking about (fifty-second day), 127.
The testicle continued in the same state, hard and swollen; eventually there came on burning pain in the left side of the scrotum, where the skin was tense over the testicle, and a large abscess formed in the dartos and cellular tissue. This was opened by a small incision, and yielded a very large quantity of semitransparent fluid, partly mixed with blood, after the discharge of which the size of the testicle became somewhat less; there was apparently no connection between the testicle and abscess, 127.
Female. [520.]
While falling asleep, quite suddenly several hysterical jerks as from the womb, with burning, irritating heat and violent pulsation in the passages; also a feeling of great pressure and bearing down (twenty-seventh night), 128.
Darting pain and thrilling sensation in the vagina, with momentary pulsation coming on at short intervals (thirty-first day), 128.
Violent tearing pains in the womb, coming on at intervals and lasting a few minutes (thirty-sixth day), 128.
The menstrual period came on the fifth day and lasted for the usual time, quite unaffected apparently by the proving. The menses came on again at the proper time, but lasted only two days, and were very scanty, 128.

RESPIRATORY ORGANS

Spasm of the muscles about the larynx and those of one arm; she felt and looked as if strangled; the muscles on each side of the larynx became tense like chords, 20.
Spasm of the respiratory muscles, so that breathing was irregular, intermittent, and difficult, 4.
Voice.
He spoke in a very low voice, which was somewhat indistinct, not only from his weakness, but from the frequent interruptions his utterance was subjected to from the violent jerks his whole frame suffered from tetanic spasms, 69.
Hoarseness, with a feeling as of a cold on the chest, lasting about two hours, in the morning (thirty-eighth day), 128.
Complete aphonia (soon), 104.
Cough.
Occasionally spasmodic explosive cough (seventh day), 127. [530.]
Dry spasmodic cough (forty-eighth day), 128.
Respiration.
Accelerated respiration, 12, 122.
Respiration quick and difficult, and attended with great pain in the præcordial region, 89.
Respiration rapid, with hard, rapid pulse, 26.
Breathing rapid and difficult, but larynx quite free (after twenty minutes), 30.
Breathing hurried, catching, and difficult, 63.
Respirations 35 per minute during the spasm, 136.
Inspiration deep, 71.
Short breathing with dry cough (fifty-fourth night), 128.
Respiration short and labored, 88. [540.]
Short breathing with dry cough (thirty-fifth day), 128.
Deep respiration, without convulsions, with loss of consciousness, followed by death, 26.
Respiration became irregular, intermittent, and short, 196.
Respiration sobbing and difficult, 122.
Choking character of breathing (after fifteen minutes), 107.
Difficult and interrupted breathing, 103 ; (soon), 164.
Respiration difficult, 25, 97.
Breathing difficult, there being short spasmodic efforts at inspiration, and the expiration accomplished by a sort of moan or sound indication of anxiety or pain, or both, 64.
Difficulty in breathing during the spasms, 136.
Respiration difficult, rattling, 3. [550.]
Breathing becomes always more and more difficult, with increasing spasms, until at last it ceased entirely for a short time, associated with arrest of the beating of the heart, 4.
Respiration difficult, stifled, tight, 33.
Respiration very difficult (after six hours), 150.
Respiration very difficult, with much motion in the larynx, 24.
Oppressed breathing, 62.
Tightness of breath, 29.
Complained of want of air, and requested the window to be opened (after five minutes), 33.
Great want of breath after the spasms, with sighing, 43.
Respiration seemed entirely suspended; no respiratory murmur detected, but the heart's sounds were quite audible, 79.
Great dyspnœa, 141. [560.]
Excessive dyspnœa, with screaming, followed by convulsions, repeated every ten minutes; the extremities became rigid; the patient could not sit; the hands were clenched; the head drawn backward; the patient was perfectly conscious and sensitive; spoke a few words, 73.
Respiration suspended during the spasms; 19, in the intervals of rest, at the close of each fit, 28, 49.
He died asphyxiated during a violent convulsive attack, which fixed all the respiratory muscles, 86.

CHEST

Walls of chest fixed, 130.
Spasmodic contraction of the muscles of the chest, about four times in a minute, with a feeling of impending suffocation (after twelve hours), 126.
Considerable oppression of the chest; constriction when taking a long breath (after twelve hours), 43.
Oppression in chest after meals, with flatulence (fifty-fourth day), 128.
Tightness about the chest, 33, 42, 49.
Soreness of the muscles of the chest and shoulders (twenty-second day), 128.
Sharp contractive pains in the muscles of the chest (first day), 128. [570.]
Severe, sharp pains in the muscles of the chest and in the shoulder-joints, at 7 P.M. (third day), 128.
Sharp pains in the upper part of the chest, right side, and in the top of the shoulders, coming on a short intervals (fourth day), 128.
Deep spasmodic pains in the chest and back, at 2 P.M. (eighth day), 128.
Sharp, deep pain in upper part of chest (twelfth day), 128.
Sharp darting pain in the lower part of the chest, in the evening (twenty-second day), 128.
Sharp darting pains in upper chest (twenty-seventh day), 128.
Spasmodic pains in the muscles of the chest and back part of shoulders (thirty-third day), 128.
Violent pains in the muscles of chest and neck (forty-third day), 128.
Gnawing and darting pains in the muscles of the chest and abdomen, accompanied by a sick, faint feeling (fifty-third day), 128.
Shooting pains in the muscles of the chest, left side, and under the jaws (second day), 128. [580.]
Sharp needlelike pains in upper chest and muscles of neck (thirty-fourth day), 128.
Sides.
Keen, sharp pains in the upper part of the chest, right side (eighteenth day), 128.
Keen, needlelike pains in right upper chest, in the forenoon (thirtieth day), 128.
Sharp pains in the left side under the ribs (thirty-fourth day), 128.
Severe, fixed pain in the upper part of the chest, left side (third day), 126.
Mammæ.
Severe stabbing pains in the right breast, passing through to the back, at intervals (thirty-fifth day), 128.
Violent tearing pain in the left breast, at intervals (thirty-sixth day), 128.
Sharp pains in the left breast (twenty-eighth day), 128.

HEART AND PULSE

Præcordium.
Tightness about the præcordia, 63.
During the day, dull pain shifting along the line of the aortic arch (fourth day), 127. [590.]
Fluttering sensation about the heart, with faintness, in the morning (fifty-fifth day), 128.
Heart's Action.
The heart's action was distinctly felt by the hand applied to the præcordia, 64.
Sudden palpitation of the heart, lasting a short time (forty-fourth night), 128.
Palpitation of the heart (twenty-seventh night), 128.
Tumultuous action of the heart, 9.
Impulse of heart strong (after twenty minutes), 30.
Irregular action of the heart, 145.
Pulse.
Pulse 88 and regular, 79.
Pulse regular, about 90 (between the spasms), 66.
Pulse accelerated, 3, 4, 29. [600.]
Pulse weak and rapid, 25.
Pulse very rapid, small, 122.
Pulse very rapid and easily compressed, 6.
Pulse quick, 119.
Pulse rapid, small, 106.
Pulse more rapid than usual between the spasms, 57.
Pulse about 150, 64.
Pulse frequent (about 130), but soft, 63.
Pulse 130 per minute, 121.
Pulse 120, small, regular, and corded or tense, and strong (after three hours and three-quarters), 50. [610.]
Pulse varying from 120 to 140, 131.
Pulse 115 to the minute (after one hour), 124.
Pulse 110, very compressible, 24.
Pulse 110 (after one hour and three-quarters); 140 during the spasms, 136.
Pulse 96, rather small and very irregular (after one hour), 94.
Pulse full and rapid, 138.
Pulse full, about 100, 43.
Pulse large and full, 73.
Pulse full and strong, but irregular, 82.
Pulse hard, full, slow, intermittent, 3. [620.]
Pulse weak, rapid, and almost imperceptible, 130.
Pulse 70, hard and contracted, 139.
Pulse small and frequent, 42, 97.
Pulse small and slow (after one hour and a half), 46.
Pulse small, suppressed and rapid, 4.
Pulse imperceptible, 147.
It was impossible to count the pulse during the convulsions, and it was very little more than a flutter during the interval, the slightest touch throwing the patient into a paroxysm, 138.
Radial pulse imperceptible during the spasms; in the intervals of rest 110; at the close of each fit 128, 49.
Nearly pulseless (after one hour), 69.

NECK AND BACK

Neck.
Neck swollen, the jugular veins distended, 4. [630.]
Marked rigidity of cervical muscles (after one hour), 124.
When she tried to lift her head the neck felt very stiff, 107.
Peculiar contractions of the muscles of the neck, especially the sterno-cleido-mastoids (after a few minutes), 141.
Neck feels stiff, 43.
Painful stiffness in muscles of neck and chest, extending down the back to the waist (forty-sixth day), 128.
Stiffness of nape of neck, with darting pains in the head and neck, in the morning (thirty-sixth day), 128.
Stiff hard feeling of the muscles of the neck (fourth day), 128.
Momentary stiffness in left half of neck (twenty-sixth night), 126.
Hard rigidity of the muscles of the neck (thirty-fourth day), 126.
Stiff sensation in the muscles of the neck, extending down the back to the waist (thirty-fifth day), 126. [640.]
Sharp cramp pains in the muscles of the neck (tenth day), 128.
Violent pains in the muscles of the neck and down the spine, in the forenoon (twenty-second day), 126.
Darting pains in the muscles of neck and to of shoulders (thirty-fifth day), 128.
Keen knifelike pains in the muscles of neck, chest, and abdomen, with sick feeling (forty-first day), 128.
Sharp darting pains in the muscles of the neck, in the morning (forty-second day), 128.
Violent pains in the muscles of neck and chest (forty-third day), 128.
Sharp needlelike stitches in muscles of the neck and in upper chest (thirty-fourth day), 128.
Intense gnawing pain in the left half of the neck, at night (seventh day), 128.
Dull aching pains at the nape of the neck and up behind the ears (first day), 128.
Violent pain in the nape of the neck and down the spine, at intervals, and lasting several hours, in the forenoon (twenty-third day), 128. [650.]
Sharp pain in nape of neck and down the spine at intervals (twenty-fifth day), 128.
Sharp pains in the muscles of the neck and down the spine at intervals, at noon (twenty-sixth day), 128.
Sharp cutting pains in nape of neck (twenty-seventh day), 128.
Sharp stabbing pains in the nape of the neck and down the spine, in the morning (thirty-fifth day), 128.
Sharp darting pains in nape of neck and bottom of left heel (thirty-eighth day), 128.
Violent pains in the muscles of the nape of neck and over the shoulders to the chest (forty-first day), 128.
Shooting pains in nape of neck at intervals, in the afternoon (forty-ninth day), 128.
Darting pains and contracted feeling in the back of the neck and head and behind the ears (fourth day), 128.
Severe darting pains in the back of the neck and head (eleventh day), 128.
Pains in the muscles of the back of the neck and articulation of the jaws (twelfth day), 128. [660.]
Severe pains in the muscles of back of neck (thirty-third day), 128.
Darting pains in back of neck and in left breast (thirty-seventh day), 128.
Sharp darting pain in back of neck and down the spine, in the afternoon (thirty-ninth day), 128.
Sharp pain in muscles of back of neck (fiftieth day), 128.
Pains in the muscles of back of neck (forty-fifth day), 128.
Sharp needlelike pains in muscles of back of neck (fifty-third day), 128.
Back.
Stiffness of the back; it is very painful to move about, in the morning (fifty-first day), 128.
Spine feels stiff, as if an iron rod were pushed from one end of it to the other, 43.
Stiffening sensation down the back (seventeenth day), 128.
Stiffness down the spine and in the knees (eighteenth day), 128. [670.]
Extreme stiffness of the back (nineteenth day), 128.
Stiffness of the back, and the same sharp darting pain at nape of neck, at intervals (fortieth day), 128.
Tight stiff sensation up the spine when bending the head down (second day), 128.
Stiffening of the muscles of the back and neck, following a similar sensation in the muscles of the legs (fourteenth day), 128.
Hard rigid feeling in the muscles of the back and neck; darting pains in the back and neck (twenty-fourth day), 128.
Intense aching and stiffness in back, after standing or walking (fifty-second day), 128.
Convulsive jerks in the back, when attempting to open the mouth (fiftieth day), 128.
Violent jerks in the spinal column, from the waist upwards (fiftieth day), 128.
Great muscular soreness, principally of the muscles along the spine, 115.
Sore pains and stiffness of the back (sixteenth day), 128. [680.]
Deep sore sensation in the left half of the back above the waist (forty-first day), 128.
Intense aching down the spine and behind the ears (twenty-fourth day), 128.
Aching of the back and over the hips (forty-first day), 128.
Extreme aching and stiffness of the back (forty-sixth day), 128.
Rheumatic pains in left half of back about the waist (thirteenth day), 126.
Intense aching and icy coldness of the entire back (thirteenth day), 126.
Intense pain in the back, aggravated by the least exertion; constant aching around the waist, in the morning (fiftieth day), 128.
Violent pains along the spine, followed by frightful twitching, tetanic spasms, and death, 41.
Pains in the back, 25.
Increased pain in the back (fiftieth day), 128. [690.]
A great deal of pain up and down the spine, 43.
Agonizing gnawing pain in the back and neck, and in the muscles of the legs above the knees (fourteenth day), 128.
Intense gnawing pain in the left half of the back from the shoulders to the waist, in the forenoon (eighth day), 128.
Sharp pains and aching in the back (forty-second day), 128.
Sharp tearing pains in the back, down the entire length of the spine, in the morning (twenty-first day), 128.
Sharp cutting pains at times in left half of back (twelfth day), 128.
A single stabbing pain in the upper part of back, passing down the spine, in the afternoon (thirty-second day), 128.
Contracted feeling in the muscles of neck (sixteenth day), 128.
Lumbar.
Pains in lumbar region, 143.
Sudden stiffness in the lower part of back and hips, in the afternoon (forty-fourth day), 128. [700.]
Intense aching in the small of the back (first day), 128.
Intense aching in lower part of back and over the hips, in the evening (twenty-eighth day), 128.
Aching and stiffness in lower part of back, in the afternoon (fifty-fourth day), 128.
Intense aching and stiffness in lower part of back, after standing or walking, in the evening (fifty-fifth day), 128.
Sharp needlelike pains in the back about the waist (forty-eighth day), 128.
Suddenly violent cutting pain in the back about the waist, as though she were chopped in half, extending right and left to the stomach, at night (forty-ninth day), 128.

EXTREMITIES

Fingers and toes violet-colored, the former spasmodically doubled inward and the latter drawn backward, 12.
Extremities outstretched and rigid and at times affected by jerking movements, especially rotating muscles, 78.
The arms became spasmodically drawn over the chest, the forearms immovable at the elbows; the lower extremities became rigid, 106.
During the paroxysms, arms and legs extended and rigid, 145. [710.]
Muscles of legs and arms rigidly flexed, 141.
Stiffness of the limbs, 48, 97.
Hard rigidity of the muscles of arms, legs, face, and neck (twenty-seventh day), 128.
Intense stiffness of the muscles of the legs, shoulders, and upper part of the chest, especially the calf of left leg, with external tenderness (twenty-sixth day), 128.
Stiffness of extensors of thighs and muscles of back of neck and hand, causing inability to write (fifth day), 127.
Slight stiffness of toes and arms (fifty-third day), 128.
A peculiar kind of twitching over her limbs (after one hour), 40.
Violent jerking of all the limbs, 3.
Severe drawing up of the legs and arms (after half an hour), 46.
Twitching of the limbs in bed, and spasms as if the heart was being firmly grasped (seventeenth day), 127. [720.]
Convulsive throwing about of the extremities, especially violent motions of the arms and hands towards the face, so that they had to be tightly held, with perfect consciousness and without pain, 7.
Spasms of the extremities interrupted by painful shocks, 75.
Convulsions of both upper and lower extremities, 51.
After a few minutes he began to feel tingling in his hands and arms, followed by rigidity, and spasms soon set in, 155.
Violent shuddering in the limbs as in paroxysms of ague, only on every attempt to move them; repeated in a tertian type and always ending in perspiration, 2.
Extreme weariness of the limbs, 23.
Extreme prostration and weariness of the limbs, 6.
Cramps in hands, feet, and legs (after thirty minutes), 123.
Pains in the left knee, and in the palms of the hands and left thumb, as if they would be stiffened (after five hours and three-quarters, fifth day), 128.
Violent pain in left upper leg and arm, at night (forty-second day), 128. [730.]
Violent darting pains in the muscles of the arms and hip-joints (thirty-sixth day), 128.
Violent pain in the limbs, especially in the feet, with spasmodic jerkings, 8.
Rheumatic pains in the arms and legs (fifty-fifth day), 128.
Rheumatic pains in right hand and left foot, in the afternoon (twenty-seventh day), 128.
Rheumatic pains in the muscles of the arms and left hand, also in the knees, coming on at short intervals (twelfth day), 128.
Rheumatic pains in front of thighs, and in forearms and fingers (twentieth day), 127.
Sharp cramp pains in the palm of left hand and sole of left foot (tenth day), 123.
Darting pains in the muscles of the arms and in calf of left leg (third day), 128.
Sharp tearing pains in the muscles of the arms and in the right knee, with tremulous feeling (twenty-first day), 128.
Cutting pains in the calf of left leg and in the left wrist-joint (eighth day), 128. [740.]
Sharp cutting kind of pains in the left ankle-joint, and shortly after in the left arm, at 9 A.M. (third day), 128.
Sharp pains in the right wrist, and then in the left arm from the shoulder to the wrist (second day), 128.
Sharp pain in the little finger of right hand, and at the same time such an intense aching in the ankles that she must sit down, at 10 A.M. (third day), 128.
Tingling of fingers and toes (fifty-third day), 128.
Crawling in the limbs after spasms, 10.

SUPERIOR EXTREMITIES

In about a half hour washed his hands, and immediately felt a sense of numbness, extending from the thumb to the whole of the hand and wrist, and rapidly to the elbow and shoulder. After two hours I found considerable swelling of the joints of all the fingers, and also of the wrist, but all numbness had passed off. At the time he despatched the messenger the arm was "enormously swollen and so dead that he could bang it against the wall without feeling it." On the following day the arm had recovered its normal size and appearance, 90.
Arms rigid and extended (after twenty minutes), 30.
Arms stretched out, hands clenched, 131.
Twitching of the arms (after one hour and a half), 46.
Jerking and trembling of the arms (twenty-seventh day), 128. [750.]
He had but little control over his arms; as soon as he let go his grasp on the bedstead they would jerk violently, and continue thus until he laid hold of something solid and immovable, 139.
Stiffening and twisted sensation in the arms and hands (twenty-seventh day), 128.
Rheumatic pains in the hands and arms, coming on at intervals during the day (forty-fourth day), 128.
Spasmodic jumping of the muscles of the arms, passing off suddenly (sixth day), 128.
At night when falling asleep, a peculiar spasmodic jerking, at times in the left arm only, and afterwards in the right hand (third day), 128.
A peculiar sensation about the arms and neck, accompanied with slight twitching of the muscles (soon), 39.
Shoulder.
Soreness of the muscles of the shoulders and chest (twenty-second day), 126.
Rheumatic pains in the back, part of left shoulder, and in the muscles of the arms and legs (fifteenth day), 128.
Sharp rheumatic pains in the socket of right shoulder, in the evening (fortieth day), 128.
Severe sharp pains in the shoulder-joints and in the muscles of the chest, at 7 P.M. (third day), 128. [760.]
Sharp darting pains in shoulders and elbows (sixteenth day), 128.
Sharp momentary pain in top of left shoulder, shooting down to the breast (after one hour, seventeenth day), 126.
Sharp needlelike pains in socket of right shoulder (fifty-fifth day), 128.
Arm.
Soreness of muscles of upper arms, as if beaten, in the evening (thirty-third day), 128.
Soreness in the muscles of the arms (forty-fifth day), 128.
Tenderness of muscles of upper arms (forty-second day), 128.
Keen sharp pains in the back part of left upper arm and in forepart of thighs, in the afternoon (eighteenth day), 18.
Sharp pains in muscles of left upper arm, in the evening (thirty-ninth day), 128.
Sharp pains in muscles of upper arms (fifty-second day), 128.
Elbow.
Sharp pain in the right elbow-joint, coming on at short intervals, at 5 P.M. (sixth day), 126. [770.]
Sensation as though a drop of cold water was dropping off the right elbow at short intervals, at times as if cold water dropped off the right shoulder (thirtieth day), 128.
Wrist.
So much subsultus tendinum, that I was unable to feel his pulse (after six hours), 150.
Hand.
Trembling of the hands, 25, 26 ; (twenty-fourth day), 126.
Visible twitching in the veins of right hand; it seemed as if the blood had stopped and then flowed on again (forty-seventh day), 128.
Hands partially paralyzed, so that he was not able to hold anything between the thumb and fingers; he held the cup awkwardly between the two hands, as a bear might do, 115.
Hands spasmodically clenched, 148.
The left hand feels partially clenched (eleventh day), 128.
Involuntary clenching of the hands, especially when taking hold of anything (twenty-first day), 128.
Involuntary clenching of the hands (twenty-seventh day), 128.
Stiffening of the hands; she feared to take hold of anything, and when she did she could not grasp it firmly; when stretching out her arms, the hands became involuntarily clenched, at 6 P.M. (fourteenth day), 128. [780.]
Slight stiffening of left hand (thirty-seventh day), 128.
Momentary stiffness of the muscles of the hands, with intense itching of the fingers (forty-third day), 128.
Stiffness of the hands (fiftieth night), 128.
Rheumatic pains and momentary stiffness in the hands (twentieth day), 128.
Rheumatic pains in the hands (twenty-third day), 128.
Rheumatic pains in left hand (forty-second day), 128.
Rheumatic pains and stiffness of hands, especially the fingers of left hand (forty-ninth day), 128.
Rheumatic pains in the hands, with stiffness of the fingers (fiftieth day), 128.
Cramplike pains in the palms of the hands; she can scarcely extend them (seventh day), 128.
Contractive pains in the palms of the hands, at 10 A.M. (sixth day), 128. [790.]
Violent sharp pains in the right hand (nineteenth day), 128.
Prickly numbed sensation in the left hand, at intervals during the day (seventh day), 128.
Numbed, prickly sensation in the left hand at intervals, and lasting a short time (twelfth day), 128.
Fingers.
Sharp pain in the right thumb and right great toe, at 5.30 P.M. (fourth day), 128.
Sharp needlelike pains in the ends of the fingers and toes (sixteenth day), 128.
Sudden, prickly, tingling sensation in the fingers (fiftieth day), 128.

INFERIOR EXTREMITIES

Painful convulsions of the lower extremities and nape of neck, with lightning-like pains in the lumbar region constantly shooting, 24.
Very rigid tonic contraction of all the muscles of the lower extremities, rendering them fixed in a straight, extended position; no flexion of the legs could be accomplished, either at ankle, knee, or hip, without making use of greater force than I thought justifiable; the jaws were also firmly set, and the patient could not open his mouth by any effort he was able to make; the muscles of the trunk, chest, and upper extremities were but slightly, if at all, affected (after seven hours), 181.
Lost use of his legs, 152.
Loss of power in the lower extremities, 126. [800.]
Weakness of the lower extremities, trembling and loss of power, without loss of consciousness, 11.
The gait is feeble and tottering, and a general tremor pervades the whole body on attempting to walk, 63.
Hip.
Rheumatic pain and stiffness in the hip-joints (twenty-third day), 128.
Thigh.
Stiffness in the extensor muscles of the thighs, as if they were made of wood (second day), 127.
Stiffening of the muscles of the legs, especially the forepart of the thigh (twenty-seventh day), 128.
Rheumatic pains in the muscles of the thighs, at noon (nineteenth day), 128.
Severe aching in right upper leg (fifty-fourth day), 128.
Sharp cutting pains in the muscles of the left thigh, and in both arms (fourth day), 128.
Sharp needlelike pains in the inner part of the thighs, in the afternoon (twenty-eighth day), 128.
Knee.
Slight trembling of the knees (third day), 127. [810.]
Shaking of the legs, especially the knees (seventeenth day), 128.
Extreme stiffness of the knee-joints (eleventh day), 128.
Stiffness of the knee-joints (twenty-second day), 128.
Stiffness of the knee-joints and calf of left leg, in the morning (twenty-fifth day), 128.
Sore stiffness in the knees and in the calf of right leg (nineteenth day), 128.
Stiff kind of pains in the right knee, when sitting (ninth day), 128.
Rheumatic pains and stiffness of the knees and hips (sixteenth day), 126.
Rheumatic pain and stiffness in the knees and hips (twenty-sixth night), 128.
Rheumatic pains in right knee (thirty-second day), 128.
Drawing pains, starting from the muscles of the knees, 5. [820.]
Keen needlelike pains, at intervals, in the right knee-joint (thirtieth day), 128.
Sharp needlelike pains in left knee (fifty-third night), 128.
Needlelike pains in right knee-joint (seventeenth day), 128.
Sharp cutting pain in the right knee, at night (twenty-third day), 128.
Leg.
He draws his legs towards his body very slowly, they seem very heavy to him, 43.
Trembling in the legs, with a sensation of falling (eleventh day), 128.
Shaking of the legs, with stiffening of the muscles, the stiffness being much worse, after sitting (twenty-first day), 126.
Trembling of the legs; on rising from her chair she almost falls to the ground, so unsteady and powerless does she feel in the knee-joints; immediately (twenty-fourth day), 128.
Trembling of the legs (twenty-seventh day), 126.
Sudden jerking of the legs, at night (eighteenth day), 128. [830.]
Jerking of the eyes, at night (thirty-first day), 128.
Hard rigidity of the muscles of the legs (eleventh, fourteenth, and thirty-fourth days), 128.
Stiffness in the back of the legs (twelfth day), 128.
Stiffness of the muscles of the legs, followed afterwards by a similar sensation in the muscles of the back and neck (fourteenth day), 128.
Stiffness of the legs, with intense trembling of the knees (thirty-fourth day), 128.
Stiffening and trembling of the legs (fiftieth day), 128.
Considerable stiffness of left leg and back, apparently from sympathy with the testicle, which is still swelled, and sometimes painful (forty-ninth and fifty-second days), 127.
Stiff sensation in the legs on going down stairs, especially in the knees (first day), 128.
Weakness in the legs, 145.
Intense soreness of the muscles of the legs, especially the knees, lasting for about one hour (thirty-seventh day), 128. [840.]
Agonizing gnawing pain in the muscles of the legs above the knees, and in the back and neck (fourteenth day), 126.
Intense aching in the shin bones, when walking, at noon (twentieth day), 128.
Intense aching in the shin bones, when walking (thirty-third day), 128.
Rheumatic pains in the legs, with sore stiffness in the knees and hips (twenty-first night), 126.
Rheumatic pains in the legs, from the knees upwards; at times in the joints of the knees and hips, especially in the left leg (thirteenth day), 126.
Pain in the leg, 70, 132.
Hard pain all through the legs, 43.
Tightness in his legs, 110.
Trembling, powerless feel in the legs (fourteenth day), 128.
Strange darting sensation in the calf of left leg, and in the muscles of the upper part of left arm (first day), 128. [850.]
Sharp darting pains in the calf of left leg (second day), 128.
Sharp cutting pain in the calf of left leg (twenty-third day), 128.
Cutting pains in calf of left leg (thirty-fourth day), 128.
Sharp pains in calf of left leg (thirty-sixth day), 128.
Ankle.
Severe pains in the right ankle-joint; it is very painful to walk, in the forenoon (thirty-third day), 128.
Foot.
Feet began to stiffen (immediately), 143.
A very hard steady ache across the instep of both feet, 43.
Intense aching in the feet, when walking (sixteenth day), 128.
Cramplike pains in the right foot and leg (eighth day), 128.
Cramp pains and twisted sensation in the right foot (thirty-fourth day), 126. [860.]
Violent cramplike pains in the feet, soon after the stiffening of the jaws and muscles of the face (forty-first day), 128.
Severe cramp in right foot (forty-second day), 128.
Sharp pain and twisted sensation in the feet, soon after the feeling of stupor and giddiness (forty-third day), 128.
Sharp pains in the feet, especially in the toes, with a peculiar thrilling sensation running up the legs (fifty-fourth night), 128.
Violent darting pains in the feet, especially in the bottoms of the heels (thirty-sixth day), 128.
Sharp momentary pains in the bottom of the right heel, and almost directly afterwards the same kind of pain in the right thumb and right hip-joint (after half an hour), 128.
Sharp darting pains in bottom of left heel, and in nape of neck (thirty-eighth day), 128.
Intense aching in the soles and outer sides of the feet (after three-quarters of an hour, fourteenth day), 128.
Intense aching in the soles of the feet, (nineteenth day), 128.
Violent itching, tingling feeling in the soles and palms of hands (seventeenth day), 128.
Toes. [870.]
Stiffened twisted feeling in the toes (after twenty-five minutes, twenty-seventh day), 128.
Stiffened twisted sensation in the toes (after half an hour, thirtieth day), 128.
Cramplike feeling in the toes of left foot, a sensation as if they would be drawn up, coming on at intervals, and lasting only a short time (second day), 128.
Sharp needlelike pains in the toes, with twitching of the feet and legs (twenty-seventh night), 128.

GENERALITIES

Spasmodic convulsive twitchings, 62 , etc.
Spasmodic twitching of all the muscles, and general tremors, 145.
Every muscle of the body in a state of incessant twitching, which was greatly aggravated by touch, 130.
Twitching of limbs (after two hours), followed by violent tetanic convulsions and opisthotonos; the spasms were provoked by the slightest attempt to move, the entrance of any person in the room, or the closing of a door, 140.
On raising the hand to take hold of a cup, the hand was drawn back suddenly, as if it had been burned, and there came on spasmodic twitchings of both arms; she was obliged to eat with her elbows resting upon the table, the muscles of the forearm being under control, but not those higher up (after second dose, seventeenth day), 127.
Extremely violent twitching, first in the limbs, and then in the whole left side, 3. [880.]
Violent twitching of the whole half of the body that was paralyzed, with attacks similar to apoplexy, 3.
Twitching and paroxysms of tetanic spasm, 1.
Universal muscular twitchings, 30.
Violent starting up and shuddering of the whole body, 4.
During the intervals of his periodic convulsions, sudden and powerful shocks and twitchings occurred; these were produced or increased by the slightest touch. The twitching of the muscles of the face resembled those of epilepsy, 86.
Violent electriclike starting and shuddering in the whole body, followed by opisthotonos, with excessive rigidity, 126.
Shocks, stitches, and convulsive attacks in the paralyzed part, recurring at irregular intervals, always ending with sticky perspiration, 2.
Convulsive shocks passing through the body, with fixed feeling of the jaws and eyes, lasting for at least three hours (twenty-first day), 128.
Sharp convulsive shocks, with stiffening and trembling of the muscles generally, especially of the knees and jaws, at the second shock (twenty-fourth day), 128.
A single convulsive shock in left half of the body, felt first in the left foot and running quickly up to the head (thirty-fourth day), 128. [890.]
Violent convulsive shocks, with increased shaking and stiffening, and cold perspiration (forty-first day), 128.
Extremely violent shocks in the muscles, so that the right thigh was dislocated, 74.
Painful electric like shocks in the muscles, 72.
Sudden shaking of the entire body, with stiffening of the muscles generally, especially those of the legs; she was quite unable to walk for about an hour afterwards (forty-first day), 128.
Jerkings, like electric shocks, throwing the body up several inches, with distressing pain in the limbs and nape of the neck, with alternations of tetanic spasms, asphyxia and paralytic relaxation, 6.
Paroxysms of jerking in various muscles followed by stiffness of the whole body; violent spasms, with shuddering of the whole body and opisthotonos, with groaning, followed by death, 12.
Occasional jerking of the whole body (seventeenth day), 128.
Sudden spasmodic jumping or starting of the entire body, when falling asleep (seventh day), 128.
Frequent startings, and slight pain in the lumbar spine, shooting thence down the legs (after twenty-minutes), 53.
Great muscular agitation, like that of a nervous man when under the influence of fright, 63. [900.]
Constant inclination to bend towards the right side, 11.
Tetanic shudderings (soon), 104.
General tremor over the whole body, 40.
Trembling of the whole body, with dyspnœa, 28.
Suddenly fell to the floor, complaining of inability to move his limbs, while his whole muscular system was in a state of tremor (after one hour), 134.
When going down the stairs she is obliged to hold on by the railing, so violently does she tremble (twenty-fourth day), 128.
Trembling, powerless feeling throughout the entire body, but without any stiffening, except of the jaws and fingers (thirty-first day), 128.
Trembling of the entire body, especially of the legs and hands (thirty-fourth day), 128.
Slight trembling, with confusion and giddiness (after one hour, thirty-seventh day), 128.
Convulsed, nervous, agitated feeling (twenty-seventh day), 128. [910.]
Convulsions, 143.
Convulsions recurring regularly, 2.
The upper limbs were spasmodically drawn across the chest, the forearms flexed at the elbows and immovable, the lower limbs stiff and rigid, and the feet distorted so that the soles looked towards each other, 4.
Spasm, first showing itself in the cervical muscles, then in those of the arm and chest, the latter producing slight opisthotonos, and lastly in those of the face, turning the eyes into their orbits, and setting the lower jaw firmly, 79.
Epileptic spasms for five days, beginning in the back and involving the head, 78.
Sudden spasm, associated with intense pain, lasting several minutes, 73.
Spasms returned on the slightest touch, 76.
Convulsive, spasmodic, and tetanic paroxysms, with their interval of repose, 62.
After twenty minutes she was heard to moan piteously, and almost simultaneously uttered a loud shriek. A succession of paroxysms, attended with increased cries followed; there was frightful rigidity of the limbs, accompanied by opisthotonos; also a dreadful sensation of choking, followed by death, after five hours, 57.
Spasms in from five to ten minutes; screaming; legs drawn up; feet turned inwards; body stiff, 37. [920.]
Paroxysms similar to intermittent fever, repeated at first every two weeks, and then every month, finally remaining away a year; the paroxysms lasted from half an hour to two hours, consisting of shivering of the limbs, ending with perspiration, 2.
Fell backwards in a "fit" (after fifteen minutes); constant disposition to convulsions, later; a violent convulsion, affecting the entire frame (after one hour); I corded his arm; the movement in doing this threw him into a frightful spasm, causing him to elevate his body, while he seemed to rest on his heels and the back of his head (after three hours and three-quarters); every attempt to move threatened a convulsion, 50.
In twenty minutes, convulsions, every limb shaking; short intervals of recovery in which she uttered exclamations expressive of great pain; the least motion produced another paroxysm, shaking so powerfully that it required several persons to hold her, 32.
Every few minutes had a fit of general convulsions (after twenty-minutes), 30.
Convulsions tossed the patient several inches up in bed, 24.
When falling asleep, at night, several convulsive jerks of the entire body (first day), 128.
Body rigid, head drawn backward, respiration difficult and hissing between the teeth; these spasms remitted, but returned after a few minutes, with trismus, 113.
She was lying on a bed upon her back, and to the left; jaws closed, forearms flexed across the chest, fingers clenched. During the spasms she uttered screams. In the interim she conversed; was conscious of approaching death, and attempted to swallow medicine, but most of it would be forced back. She lived about thirty minutes and died in a spasm, 111.
Found in convulsions. After the administration of emetics, spasms set in, the head being bent over a chair; a relaxation of the spasms gradually took place, the heart's action and respiration ceased, and he died ten minutes after being brought into the hospital, from tetanus, 109.
Arm moving and the body twisting in a sort of writhing motion; death in about thirty-five minutes, 107. [930.]
She suffered considerably, and was strongly convulsed, for a long time, 94.
Convulsions came on, beginning with slight twitchings in the muscles of the lower extremities (after half an hour); violent convulsions every few minutes (after one hour), 94.
Almost the entire muscular system rigidly contracted, with occasional spasmodic action, 87.
Six convulsions in all, but only the first two were severe. He could himself foretell their onset by the intense muscular pain to which the incipient spasm gave rise, 160.
General convulsion, with some opisthotonos, 160.
Lying on her back, body rigid, jaws set, arms and hands flexed, the thumbs nearly touching across the chest, and the whole muscular system convulsed, with short jerky spasms, which would continue for about a minute and then remit, the muscles remaining contracted and as hard as wood during the intervals between the paroxysms (after half an hour), 156.
Constant twitching and spasm of the muscles; the spasms and convulsions were frightful to behold; about six hours after swallowing the poison the convulsions culminated in two of the most frightful and protracted attacks of opisthotonos either of us ever beheld, 132.
Repeated convulsions; every muscle was rigid, and tetanus complete, 151.
Convulsion ensued; spasm of the posterior muscles of the trunk predominating, with opisthotonos strongly marked. When I first saw him the intervals between the recurrence of the spasms varied from thirty to sixty seconds. There was spasm of all the muscles of voluntary motion, 146.
Convulsions; she uttered cries and vomited small quantities of an apparently alcoholic fluid; severe tremors; the convulsive movements continued, especially on touching her, 132. [940.]
Her muscles were rigid, and her body stiffened; she appeared to be in a "spasmodic fit," as he termed; there was twitching in the muscles of her shoulders; her arms, hands, and legs, as well as her body, were stiff, and her head was thrown back; he could not raise her, so he waited till the spasm had passed (after three minutes, as supposed); in a few moments the muscles relaxed; after an interval of about five minutes she went into another spasm; the teeth closed tightly, the breath forced through with considerable exertion, and she groaned as if her sufferings were intense; then came another intermission which lasted about ten minutes, when she had a third spasm, not quite so hard as the others, though similar; water was thrown in her face, which seemed to convulse her, but slightly. Her limbs were rigid, her hands half clenched, and she was frothing at the mouth; this last spasm was most severe of all; it lasted till her death, which took place in about five minutes from the commencement of the last spasm, and thirty minutes from the first attack, 116.
Lying on her back on the floor, quite sensible; arms and legs stretched out to their fullest extent; hands clenched; toes flexed; legs close together; body in a state of opisthotonos; countenance livid and anxious; eyes starting from their sockets and fixed, pupils widely dilated, conjunctiva highly injected, teeth firmly clenched, breathing irregular, and at times almost ceasing; skin hot, bathed in perspiration, and steaming; pulse rapid and scarcely perceptible; the spasms relaxed at times, but did not entirely cease for one minute, and on the slightest touch of the body or legs, or on attempting to give her anything to drink, she would immediately cry out, "My legs! My legs! hold me! hold me!" and then utter a shriek; the head would then become drawn back, arms and legs extended, hands clenched, and the body in a state of opisthotonos; face and head a deep purple; foaming at the mouth; teeth clenched; eyes protruding and fixed; heart palpitating violently, and the breathing irregular, and as if drawn through a reed. No action of the bowels or bladder took place, 106.
Convulsed; pupils dilated, pulse full and rapid; he could not swallow the mustard; the convulsions became more rapid, they were of a peculiar character; the back and body became arched and rigid; the head was bent backward, and I believe he rested on his head and heels; the slightest touch of his person brought on the spasms. He frequently cried out, "Hold my legs, lift the clothes off." At length he had a severe convulsive attack, the whole body became rigid and arched, the color of the face became dusky and almost blue; this attack lasted about a minute; during the spasm he had a sardonic grin, the teeth were exposed, the muscles of the face drawn, and in that condition he died in about twenty minutes after he took the medicine, 135.
Every three or six minutes a paroxysm of horrible convulsions of the whole body, catalepsy, with opisthotonos, contraction of the abdominal muscles, loss of consciousness, the limbs cold and muscles hard, face of a cherry color, respiration impeded, and convulsive motion of the facial muscles; these paroxysms would last a minute, after which the limbs would regain their flexibility, and respiration would proceed normally (after second powder), 129.
Immediately everything seemed to turn green, and he suddenly fell to the floor, with inability to move his limbs, while his whole muscular system was in a state of tremor. He remained unable to move for about five hours, when he succeeded in reaching the nearest house in the course of two hours by walking and crawling between the spasms, which were of frequent occurrence. Violent spasms occurred at intervals of about half an hour, and about four thrills per minute passing through the system (after twelve hours), 126.
In fifteen minutes lying on back, convulsed constantly with the severest form of tetanic spasms. At times his whole muscular system was rigid, and he lay in the opisthotonos position, resting upon his head and heels, with the body raised from the floor in the form of an arch. Several of these terrible spasms occurred in the space of a minute; his jaws were firmly locked, and the approach of anything toward the mouth caused a recurrence of the spasms, 91.
Spasms of the lower limbs, afterwards he was seized with a violent attack of convulsions, during which the face was pallid and assumed a tetanoid expression, and it was impossible to move, or even touch him, without exciting horrible convulsions, which shook, not only the bed, but the room. At the height of the paroxysm the body was raised off the bed, as in opisthotonos, and then fell heavily. These effects were produced even by the act of feeling of the pulse, or moving the bedclothes. The arms were thrown above the head by the first attacks of spasms, but subsequently they were thrown violently forward across the body, and greatly agitated. The eyes, during the spasms, were open, not turned up or congested. The pulse became exceedingly quick, and the respirations were 44 in the minute. The thorax heaved much, and some urine was voided during the fits, 83.
Partially conscious, but unable to answer questions intelligibly; in a very few minutes he seemed to be entirely unconscious and would say nothing; he straightened out and became quite stiff. During the hour and a half that followed, the spasms of the patient were so severe that it took three, and often four persons to keep him on the bed; he would throw himself about, snap at a hand that touched him, strike, and kick; suddenly his body would curve backward and rest on the head and heels, with the elbows on the bed at the sides; the muscles would continue to contract, drawing the head farther and farther back, until the occiput almost touched the spine, and the face was buried in the pillow; occasionally he would extend his arms at the side, with the fingers straight and separated, and rising to the sitting posture would stare wildly about the room, as if fearing some danger. As the symptoms grew worse he would take a long breath, straighten out and remain quite rigid, and it would seem as if that was to be his last breath. The intervals between the spasms were very short, and much of the time there was an almost constant repetition of the above-mentioned features, 157.
On touching him, great agitation and jerking, immediately followed by a loud, sharp scream, increased suffusion and redness of the face, mouth open and stretched laterally, lips livid, eyes staring and much suffused, pupils dilated, head thrown back, spine and neck bowed, arms and legs rigid and cold. The fingers were straight, but bent at their metacarpal articulations, so that their points almost touched the palms of his hands, and the toes were also straight, but bent at their metatarsal articulations towards the sole, which was very much incurved. The muscular contractions were especially noticeable in the stump of the left leg, which had been amputated some years before, almost conveying the impression that the cicatrix would burst open. The attempts to respire were attended with great distress, and suffocation seemed imminent. The length of time between the fits varied, but during the time I watched him the intervals could seldom have exceeded five minutes. A medical student, who took careful observations and notes of the case, states that "the spasms occurred in groups of two or three, followed each other at intervals of about two minutes," then there was a longer interval, then another group, and so on. During the intervals the patient was perfectly sensible, in fact, his senses were preternaturally acute, and the slightest noise in the room, the play of children on a green some yards from the house, were all noticed as exciting causes in the production of spasms. During the spasms excruciating pain, with a feeling "as if his heart was coming into his throat," and accompanied by a sensation which he compared to "plunging through a wave when bathing," 155.
When I saw her she was lying with limbs extended, and somewhat rigid; feet everted, head thrown slightly back, neck stiff, countenance pale and anxious, eyes wide open, pupils large, eye balls oscillating at short intervals, skin moist and cool, pulse 84, full and soft. On touching her wrist to feel the pulse, she was thrown into severe tetanic spasm of the voluntary muscles, worse in the arm touched, and in the muscles of the back of the neck. After two doses of Tannic acid the spasms became more violent, there was trismus, the jaws closing tightly on the cup whenever she attempted to take anything; general spasms, accompanied by opisthotonos and asphyxia followed, 134. [950.]
Convulsions; the paroxysms came on every three or four minutes; he was conscious of their approach, and entreated us to hold him, to raise him up, or to lift him out of bed, till his body became fixed, his head drawn back, and articulation impossible. In this condition of complete opisthotonos he remained for about a minute, his face livid, and death apparently inevitable, 149.
Tetanoid convulsions affecting the muscles of the trunk and spine; a rigid and tetanoid state of the muscles of the lower and upper extremities; the limbs extended, and the feet and hands drawn powerfully inwards, the patient seeming to touch the floor only with the head and heels, 147.
In the course of five minutes I began to feel slight cramps in the calves of my legs. The cramps increased in intensity and extended to the feet and thighs, causing the most intense pain. I attempted to rise from the chair, but fell to the floor with convulsions in the lower extremities, which became violent on the least attempt to move, and the feet were drawn in toward each other, becoming stiff and immovable, save as the occasional convulsions shook them. Unsuccessful attempts were made to bathe them in hot water, each effort to raise me bringing on a violent paroxysm, in the last one of which I thought my jaws had become unhinged. I was now perfectly paralyzed from the hips down, and suffering the most exquisite pains, which began to extend upward, the muscles of the shoulders and neck soon being considerably convulsed, the forearms still being free from pain. I now bade my wife "good-bye," and prepared for the final struggle, which I knew must be near at hand, as I had now become rigid from the neck down (save the forearms); the convulsions of the muscles were becoming fearful, and the torture awful to endure. And now came on a tremendous convulsion. My hands were drawn into my sides, with the fingers drawn apart and slightly bowed, and the jaws became rigid. I felt myself raised as if by some mighty power, and fixed immovably, with only my feet and head touching anything. I heard some one say, "It is all over with him," and felt something like a black pall settling down upon my brain, when I became unconscious of everything except my own agony, which was now beyond all description. I could feel my heart fluttering like a wounded bird, and my brain beating and throbbing with an irregular motion, as though at every beat it would burst from its confinement. Every joint was locked, and every drop of blood seemed stagnated. I remember thinking that it could not last long thus, when I must have lost consciousness, 147.
The patient was lying on his back, in bed; his body slightly inclined to the right side; face and body covered with profuse perspiration; countenance indicating the most intense pain and fear; head thrown back, and the muscles of the neck and back greatly contracted. This opisthotonic condition would last only a short time (the exact time not observed), and then gradually subside. The remission would not be complete before the trismatic symptoms would again return with increased severity. The pulse varied from 90 to 110 beats. The mind remained unimpaired, and also deglutition and articulation, except when the spasm was on him, 81.
In about forty minutes he was taken with a fit; he was lying on his back, touching the bed only with his head and heels, and in violent tetanic spasm; his legs, arms, and hands were stretched to the widest possible distension; his mouth was gaped open, as if kept asunder with a gag; his face was purple; his eyes were puffed; his pupils immovable; his nostrils distended; every muscle of the body in the strictest tension, and respiration entirely suspended. His heart, however, was beating, and with a regularity and tranquillity that, under the circumstances, was very remarkable. He remained in this situation for a minute or more, when the action of the muscles was suddenly reversed, drawing his head and thighs violently together, and jerking him almost off the bed. He now seemed conscious of the imminent danger of suffocation, and turning his eye imploringly to his friends, made the most distressing and desperate attempts to gasp and clear his throat. A little tenacious mucus was finally forced up into the mouth; the spasm of the glottis was relaxed; a long sighing inspiration occurred; the convulsion ceased, and he fell back on his pillow exhausted, but perfectly conscious. This intermission was short, and again the same congeries of symptoms appeared, perhaps more intensely violent, certainly of longer duration; and thus they were repeated, with almost unabated force and frequency, for three hours. The convulsions, as they came on were always tetanic in their form, but often ended in the epileptic, being scarcely absent, however, in one or the other form, two minutes consecutively, for the first two hours immediately subsequent to my seeing him, and the patient being often unable to utter a word for fifteen or twenty minutes at time. Once or twice the respiration was suspended for so long a time that I feared he had ceased to breathe forever, 80.
Convulsions, with slight rigidity; she was very sensitive to external impressions, the contact of the cup to the lips being sufficient to produce a paroxysm requiring four men to confine her to the bed, lasting two or three minutes; the paroxysms, occurred every five minutes when she was quiet; the least movement or touch was sufficient to renew the immediately, 71.
His head became suddenly and convulsively retracted or drawn back; the spasms were violent, and seemed to cause him great pain, as expressed by the varied contortions of his features; the prevailing form of spasm now affecting the trunk seemed to me exactly that which is called the opisthotonos of tetanus; the muscles felt remarkably rigid, not only during the actual spasms, but also during the intervals between them; the spasms would not come on regularly and spontaneously, but during the short intervals that occurred between them, the slightest touch on the surface would reproduce them before the moment of their recurrence would arrive (after one hour), 69.
Spasm of the muscles of the neck; when I put my hand under his head to assist him to drink, I could not raise it from the pillow; next, his teeth were so firmly clenched that two men could not separate his jaws; then his knee-joints became as rigid as bars of iron; and, lastly, his body was raised off the bed and rested on the head and heels; the spasms were slight at first, but speedily became terribly severe; they were not constant, but alternated by intervals of repose, 67.
A fit came on, indicated at first by a slight heaving motion of the person, the body rising and falling alternately with the spasms. This motion continued slow at first, but gradually increased, and with it the patient's distress and anxiety, until the arms and hands were affected with similar spasmodic action and drawn up to the breast; breathing was suppressed, except only an occasional catching and by short gasps; the head thrown more and more backward, opisthotonos increasing; face distorted by the spasmodic action of its muscles, and rendered ghastly by its variations of color from red to white, and then quickly to a livid or purple hue; eyes staring, and as the fit increased, shaking the body in a fearful degree; the large dilatation of the pupils suddenly appeared, indicating the approach of general muscular relaxation and fatal exhaustion of the vital energies, as the consequences of so terrible a struggle, and such indeed was the case, for with a few faint efforts to breathe, all signs of vitality ceased, 63.
Several spasms had occurred, and one was instantly induced upon my offering her a little whisky and water in a spoon. She opened the mouth to receive it, and immediately the teeth were closed spasmodically, and the whole frame, though still rigid, shaken as by a fit of epilepsy. The arms were brought suddenly against the chest, the hands pressing the throat with spasmodic action. Respiration ceased; the eyes grew more staring, and as if projecting from the head, the pupils dilating meanwhile. Although the interval between the paroxysms, after using chloroform, was at first apparently lengthened, it subsequently grew shorter and shorter. The length of the first was about fifteen minutes, the second nine minutes, the third about five to seven, and so on until there was but little or no intermission of the spasms, and these grew more violent. The fourth or fifth was terrific-beyond description, beginning, as the others, with suspension of respiration and clonic spasm of the arms and hands, and a tremulous agitation of the whole body. The color of the face came and went with a rapidity which astonished the beholder, till the florid changed to a purple, and this only in isolated spots with a boundary of distinct white. On the neck, shoulders, and chest, this rapid transition of color was also observed. Added to this was the distortion of countenance, occasioned by the spasm of the facial muscles, giving almost every conceivable variety of horrible expression which the human face is capable of assuming. And over and above all, the feature most conspicuous, and which gave intensity to the scene of horror, was the eye. The lids expanded to their utmost capacity; the eyeballs seemed fairly to stand out from their sockets, staring with the expression of a demon, while the doubly rapid dilatation of the pupils to their fullest extent gave an unearthly glare that was awful to look upon, forming together a tout ensemble of the terrific expressions such as might aptly represent our truest ideal of the impersonation of all evil, 64. [960.]
She awoke and screamed out "I am poisoned!" started up in bed, fell back again, sprang up again, vomited, fell back in bed again, beat the bedclothes violently with her arms, became convulsed all over, then stiff, her eyes staring in her head, and her features contorted. Soon, again, she sprang up in bed with a wildly-frightened aspect, uttered a suppressed shriek, fell back in bed, the left side being convulsed; beat the bedclothes with her arms; was oppressed for want of breath, not gasping, but could not breathe; could not inflate the lungs, the muscles of the chest contracting so violently; the eyes prominent; pupils dilated, with a glaring, staring, wildly-anxious gaze; features contorted; mouth drawn to one side; the convulsions spasmodic, agitated twitchings, assuming a tetanic form; she became quite stiff, 61.
Spasmodic attack more or less severe; the last of these seemed to be induced by the application of a cup to the lips, and was very intense and prolonged; the patient started suddenly up in bed, his whole frame being in a state of complete opisthotonos; the respiration at first impeded, became suspended, and it was only by the continuance of long artificial respiration that it was restored; the limbs were rigid and the fingers clenched; pupils dilated; during the spasms, evident relief was afforded by forcible extension of the body; in the intervals, there was constant twitches of the extremities, 54.
About an hour and a quarter after he had taken some pills, violent screaming; beating of bedclothes with his arms; complained of feeling of suffocation; head drawn back; moving, as by jumping or jerking, both in the head and all over the body; difficult breathing; eyes projecting; gasped when he spoke as if difficult for him; hands fixed and stiff, asked to be rubbed; twitchings in the arms and body during the rubbing; twitched all over. In taking some liquid, he snatched at the spoon and seemed to bite very hard; his body was then jerking and jumping; snapped in the same way at a glass containing a draught which was given to him; fit lasted half an hour, then became composed. Twenty-four hours after this attack, from which he perfectly recovered, seized with another and more severe attack, about an hour after taking two pills; started up; stiffness of neck, which he asked to have rubbed; uttered loud screams; dreadfully convulsed in all the muscles of the body; opisthotonos; complained of suffocation; asked to be lifted up and turned over; could not be done owing to the rigidity of the whole body; quite conscious; heart's action gradually ceased, and he died tranquilly about on hours and a quarter after taking the pills, 53.
Starting every fifteen or twenty seconds as if he felt an electric shock; the spasms all resemble each other, and only differ in degree of severity and time of continuance, the lightest lasting about ten seconds, and the most severe holding on for five minutes. A description of one will give an idea of them all. He starts very suddenly, and immediately his legs are drawn asunder as far as possible; his body is curved upward, so that his head and heels only touch the floor, a foot or more of space intervening between it and his back; the muscles of the arms and legs are rigid; those of respiration are frightfully affected so that it is with great difficulty that he breathes at all; his face becomes blue, then almost black; jaws tightly closed, and the stomach, partaking in the general contraction, forces up its contents, which stream in jets through his clenched teeth; at times his hands and arms are free from spasms, and in the more severe paroxysms he used his fingers to force open his teeth and mouth that he might vomit and breathe more freely; he calls upon us in every such spasm to press upon his abdomen to keep his back down to the floor; the opisthotonos seems partially overcome by this action. His spasm has now held on more than three minutes, during which he has not breathed at all; he has lost all consciousness, and indeed exhibits all the appearance of a suffocated man; his tongue protrudes; his eyes stand out from their sockets; we can perceive no action of his pulse or heart; and yet the paroxysm holds on notwithstanding all we can do to overcome it; at last the muscles relax and the spasm gives way; he does not seem to breathe; presently reviving under some stimulants, he remarks, "I can't stand another like that." He was not without spasms, more or less severe, for any longer time than one minute during four hours. He can lie in no position but on his back; whenever he turns to one side the opisthotonos is terrific, and compels him at once to turn on his back and call for pressure upon his abdomen. Every spasm seemed to him like an electric shock; the moving of a chair or any other noise, however trifling, gave rise to a spasm; he says it seems to him as if the noise itself were material, or that from the noise came something material down his spine; seems as if a stroke of lightning came to him from the place where the noise was produced; the slightest touch, even of a feather, upon his toe gave rise to a hard spasm; when no motion or noise occurred in the room or in the house, and nothing touched him, he seemed more quiet. During the more severe spasms, he felt as if dying from intense suffering all over the body, with heat and intense pain in the head; felt as if he "was passing into death." We were fully persuaded that the convulsive force seemed to be augmented by any long-continued quiet; he invariably had a harder spasm when from stillness of the room he had remained for a few minutes unaffected by spasm and resting; the force seemed to accumulate, 43.
The attempt of the patient to take liquids was followed by so violent a spasmodic fit as to prevent her swallowing it, and to give that apparent dread of water so well marked in cases of hydrophobia. Even after her request for water, on attempting to give it, she would find herself so incapable of swallowing it as to request that its administration might be deferred until the fit was over, the effort to place the cup to the mouth being generally sufficient in itself to induce a relapse of the spasms, 40.
Lying back in the chair in a very convulsed state, every limb shaking. She was placed in an easy reclining position, and in a short time she partially recovered; but for a considerable period the shaking was so powerful that it took several persons to hold her hands open, which it was thought would be beneficial. There were short intervals of recovery, during which she uttered some exclamations expressive of great pain; but the least motion produced another paroxysm, and in this state she continued for nearly two hours, when she died, 31.
Found in a state of convulsions; one of these fits lasted several minutes; the body was thrown out of the bed by the simultaneous contraction of the extremities; the face was swollen and purple; the eyes fixed and looking upwards; the respiration but little affected; the pulse full, small, and intermittent; the surface of the body covered with a cold sweat; after various attempts to swallow, spasmodic action of the gullet prevented the passage of both liquids and solids; during the brief intervals between the attacks, the patient lay perfectly quiet, snoring, and insensible; after six severe attacks, within half an hour, he died, 27.
Violent spasms like epilepsy, 3.
On attempting to rise from a chair was thrown violently backward, as quick as lightning, and remained fixed upon the chair for an hour and a half, 2.
Severe spasmodic attack, her body quivering as though under the influence of a galvanic shock, accompanied with difficulty of breathing; attacks increased in violence; when cold water was applied to her lips the twitching returned, 70. [970.]
Frightfully convulsed, her head being thrown backwards by the violence of the spasm, her arms and legs being at the same time affected with severe spasms, and her jaws firmly closed, 39.
Violent convulsions; the spasms contracted and bent the feet, and the hands were clenched, too, and he died in one of the convulsions, quite black in the face, 59.
Violently convulsed (in ten minutes), 44.
Violent spasms, during which she shricked out, the body being perfectly rigid and arched, resting upon the extremities, 48.
Severe twitching of the muscles (after first dose); violent convulsions (after second dose), 45.
Violent spasms, accompanied by violent shocks in the abdomen, 22.
Very much convulsed and cramped (soon), 35.
Frightful spasms, with black color ot the face, 114.
Extensive, frequent and severe spasms, and with each a blowing of froth from the mouth (after three hours); sensitiveness to external impressions increased, so that the spasms, like electric shocks, would ensue upon the slightest causes as the touching of the bed, contact of a spoon upon the lips, a sudden step, a jarring of the room, or the slightest noise (after twelve hours), 12.
Frequent spasms (after one hour), 124. [980.]
Fearful spasms, 102.
Fell on the floor and died in violent convulsions (after half an hour), 101.
Fell to the floor, screaming with pain in his legs (after two hours and a half); violent spasm, resting on his head and heels, his teeth firmly clenched, his eyes open and staring from their sockets, pupils dilated, and countenance livid (after three hours), 99.
Violent convulsions; she was sensible during the intervals of the paroxysms, and frequently said, "Keep me down," 91.
Strongly convulsed, with every symptom of tetanus, 93.
Violent clonic spasms, 139.
Violent paroxysms every five or ten minutes, 131.
Body and limbs perfectly rigid with spasms, which, when occasionally relaxed, was excited by merely blowing in the face, or by the shaking of the floor in walking, 133.
Stretched on his back; countenance expressive of the most painful suffering and distress his frame shaken by convulsive spasms; his limbs rigidly extended; his head slightly bent backwards; his feelings so morbidly acute that the slightest touch seemed to aggravate his suffering and to bring on a spasm, 89.
The terrible spasms of the muscular system, the lightning-like jerks of the limbs, the throat-latch grip, strangulation, and all the horrible phenomena attending a fatal dose of this medicine; the doctor went through the whole catalogue of the horrors and sufferings of a living death, and during the latter part of the night it seemed impossible that he could live; he was finally relieved by Chloroform and Morphia in solution, but the muscular spasms did not entirely cease until the afternoon of the next day, and the lameness or stiffness of the limbs and neck, and consequent debility of such an experience as he went through, continued for several days. During all the long hours of his unspeakable suffering, through that night and the next day, and when it seemed impossible that he could live through another spasmodic shock, his mind was perfectly clear, and he was entirely resigned to his fate, 120. [990.]
Violent convulsions and opisthotonos, 113.
Lying on his back in terrific convulsions; the heels, head and elbows firmly pressed into the bed, in paroxysms in which the body seemed entirely supported on these points; the paroxysms were short, and came in rapid succession, perhaps lasting two minutes, with intervals of half a minute or less; they came on with violent clonic convulsions, in which the muscles of the dorsal surface greatly prevailed over those in front; they quickly became more quiet and steady in their action, and gradually relaxed until the body came in general contact with the bed; the tetanic rigidity remained in some degree till the next paroxysm, with was not postponed more than half a minute; a slight touch of the forehead produced a violent convulsion with the suddenness of an electric shock: the accidental touching of his foot produced a like result, 115.
Violent convulsions, like electric shocks, passing through the chest, jerking the whole chest and body up so that the shoulders would strike and rebound; neck drawn, with constant grappling of the same by his hands, indicating strangulation or asphyxia, with the hollow of the feet in each of the inferior extremities drawn inward. During the whole of the spasms the heart beat feebly, though regularly; eyes open with a vacant stare; pupils contracted; palpebræ passive or apparently paralyzed, 84.
He lost all control over his limbs, and fell down in violent fits; he raised a peculiar loud sobbing shout; the head was thrown back violently; the jaws became locked; the muscles of the neck started into rigid relief; the arms, trunk, and legs shot out into a straight line, and but for the assistants he would have fallen like a log of wood on the floor; the muscles felt as hard as iron, and exhibited a tremulous vibration similar to that produced by the action of a strong electro-galvanic current; the fit lasted three minutes, and recurred at intervals of ten or twelve, being succeeded by great prostration, rapid pulse, hurried breathing, and profuse sweating; the spasms were excited by the gentlest stimulants, such as feeling the pulse, touching the feet, or moving the bedclothes (the effects of which he likened to an electric shock); in offering him a pill or little water to swallow, a forcible blowing expiration took place, from spasm of the respiratory muscles and buccinators, 49.
He asked for drink, but took it with difficulty, as the attempt brought on convulsions, and was effected only after several attempts; when swallowed, it was ejected by jerks, 86.
The severe fits were comparatively few, but between them slight fits came on in rapid succession; indeed, the attempt to take any liquid would generally be sufficient to induce one, and even merely pressing gently the muscles of the jaw, or an attempt to open the mouth by pressing on the lips and teeth, was sufficient to excite an attack, 40.
In three-quarters of an hour violent spasms, subsiding at intervals of from four to eight minutes; during spasms, violent shaking of whole body, which was extended, stiff, and rigid; spasms at first most marked in back and legs; in ten to fifteen minutes they fixed upon the thorax; violent tetanus supervened; fixation of all the muscles of inspiration, 47.
Application of the hand to the abdomen caused the countenance to change color and brought on rigors (after ten hours), 132.
Could not move without convulsive action (after thirty minutes), 125.
Tetanus, 8. [1000.]
General tetanic convulsions and trismus, for six hours, 10.
Convulsed constantly with the severest for of tetanic spasms, and at times his whole muscular system was rigid and he lay in the opisthotonos position, resting upon his head and his heels, with his body raised clear from the floor in the form of an arch. Several of these terrible spasms occurred in the space of a minute. His jaws were firmly locked, so that he could not swallow, and the approach of anything towards his mouth caused a recurrence of the spasms, 83.
Trismus, with the upper and lower extremities completely rigid, and paroxysms of opisthotonos and emprosthotonos occurring alternately. A paroxysm now took place every six minutes, each one lasting about two minutes, and during the emprosthotonic condition he uttered a violent shriek, 44.
Contracted state of the whole muscular system; the body assumes a tetanoid condition. There is a superexcitation of the nerves, proceeding from the cerebro-spinal axis, 65.
The effect of this agent, when given in small doses, repeated at regular intervals, are of a tonic character, 65.
The slightest noise or touch caused tetanic spasms, during which the patient uttered frightful screams, 28.
Tetanus and opisthotonos, with trembling and trismus, 122.
Tetanic spasms, with asphyxia, alternating with paralytic relaxation, 24.
Tetanic contraction of the extensors of the forearms and hands, with frequent twitching of the extensor tendons, followed by tetanic rigidity; head violently thrown backward or to one side: these spasms were followed by remissions and recurrence, 118.
Whole body affected by tetanic spasms; arms tightly crossed over the chest; head drawn backward; eyes distorted; frothing from the mouth; face livid; the spasms remitted for a few seconds, but returned more violent than before, 112. [1010.]
When brought into the hospital he had several tetanoid convulsions, 79.
Strong tetanic spasms (after one hour), 88.
Almost completely tetanic, 87a.
He conversed in gasps, asked to be held when the tetanic attacks were coming on and to be turned over during their presence, 86.
Tetanic spasm; the head and neck were drawn back; the face from being flushed became colorless, livid; the eyeballs rolled; and the pupils became largely dilated; the forearms were semiflexed and pronated, and the wrists and fingers flexed and pressed upon the chest, upon which she begged the bystanders to "brize," to prevent the arching of the spine; the lower extremities were widely separated, resting on the heels, with the feet moderately extended; perfectly rigid; opisthotonos; the pulse, which had been full and compressible during the paroxysm, became rapid, small, and almost indistinct. After the lapse of some minutes the spasm relaxed, the face again became colored, the eyes red, and the pupils natural. Several spasms followed, in one of which she died asphyxiated, 96.
The effects produced by the action of Strychnia manifestly proceed from its action on the spinal column, and this is not generally of such a nature as to exhibit any visible alteration, even to the scrutinizing examination of the microscope. The muscular system is thrown into violent tetanic action, resulting in decided opisthotonos, and, notwithstanding this, the cerebrum seems but slightly affected, since the mind of the person, laboring under these violent convulsions, may be clear and undisturbed. His intellectual faculties will be unimpaired by the action of the Strychnia, and rational answers will be quickly given in reply to all questions propounded to him. The effect must be slight on the cerebrum, but the whole force of the poison is expended on the medulla oblongata and the medulla spinalis, 76.
During the tetanic fits the body was stiffened and straightened, the neck violently drawn back, the chest fixed, the eyes protruding from their sockets in a horrible manner, the legs pushed out and widely separated, the muscles of the face convulsed, pulse imperceptible, and no breathing could be perceived; the face was livid, more particularly the lips, and froth issued from the mouth. During the paroxysm the pupil was much dilated, becoming contracted after the violence of the fit had subsided, 40.
Lying upon the bed in a complete tetanic convulsion, his head somewhat drawn back, countenance completely livid, with some frothy matter issuing from his mouth, with frequent moans; the palpebra in constant motion; this first paroxysm may have lasted some five minutes, which was succeeded by an interval of partial calm; this interval lasted perhaps five minutes, when another paroxysm commenced by a little starting and stiffening of the extremities, and immediately the whole body was thrown into a tetanic paroxysm, in appearance like the first, and lasted two or three minutes, when death ended the struggle. The time of taking the article till death ensued could not have been over twenty minutes, 34.
Extremely violent tetanic shocks, 103.
Very violent tetanic convulsions; the extremities, upper and lower, were perfectly rigid and extended. The patient trembled violently, and was on shaking mass in constant motion, 68. [1020.]
Violent tetanic spasms in rapid succession, like the effect of shocks from an electrical battery; occasionally they would relax for a moment, but the slightest touch upon the surface, or an attempt to present anything to his mouth seemed to redouble their violence; the convulsive movements precluded the possibility of deglutition of an emetic, 62.
An attempt to give emetics produced a most severe tetanic spasm. The jaw wad firmly fixed, the extremities stiff, and the body bent back in a state of complete opisthotonos, 56.
On rising up that the spine might be examined, he was seized with a violent tetanic convulsion, in which there was complete opisthotonos and great difficulty in breathing, as well as severe trismus. The fit continued for about four minutes, 53.
Violent fit of tetanus, 40.
Violent tetanic convulsions, 158.
Violent tetanic spasm, the limbs extended and rigid, the jaws firmly fixed, and the body in a state of opisthotonos, 100.
Violent tetanic spasms, peculiar in that they were produced whenever any one approached the bed, whenever she was spoken to, whenever the covers were lifted, and on the slightest touch, as from feeling the pulse; the spasms lasted several minutes; did not completely relax in the masseter muscles; those of the upper arms and calves remained rigid and contracted; the convulsions were ushered in by screaming; there was no impairment of consciousness, 105.
On raising the eyelids, in order to ascertain the state of the pupils, a violent tetanic paroxysm was induced; just as the spasm commenced, the patient shrieked out, "Hold my legs; I am dying, I kind I am!" The attacks rapidly succeeded each other and gradually increased in severity, 100.
In about one hour she was seized with terrific tetanic convulsions, which lasted several hours, 23.
Violent tetanic spasms, lasting each of them for about half a minute; they lasted altogether about a quarter of an hour (after two hours), 116. [1030.]
Violent tetanic spasms of almost all the muscles; the head thrown back; respiration difficult from the spasms of the respiratory muscles; congested appearance of the face, with a wild or anxious look; eyeballs prominent and staring; pupils dilated; pulse in time of the most violent spasms, quick and hardly perceptible at the wrists; in intermission, full, regular, and 100 to the minute, 184.
Severe tetanic convulsion, involving nearly all the muscles of the body and extremities, which lasted for about one minute and a half. The chest was fixed; respiration became difficult; the body was bent backwards (opisthotonos). This was followed by an interval of rest and relaxation of all the muscles, but the patient seemed to be much prostrated. Slight convulsive starts and twitching of the hands followed at various intervals. After the attack the patient became so sensitive that the slightest touch or movement of the bed, or a sudden noise, would cause a spasmodic jerking of the whole body, 79.
Frightful periodical tetanic convulsions of the voluntary muscles and congestion of the face. At first opisthotonos was so severe as to force him off the bed on to the floor. During the attack the feet were inverted, the soles of the feet arched, the fingers clenched (not forcibly), the elbows flexed, the arms bent over the chest, the eyeballs fixed and protruding, pupils dilated, the neck stretched backwards and twisted. The attacks occurred at intervals of half and hour, more or less, and were so violent as to shake not only the bed but even the house, 86.
In about twenty minutes he was seized with a most violent tetanic convulsion, which lasted for about a minute, with well-marked opisthotonos. The intercostal muscles were so rigid, and his face was so blue and swollen, that is seemed as if suffocation must ensue. He appeared to suffer intense agony, and uttered most heart rending cries, 133.
The extremities began to move spasmodically, and the whole system seemed to be under the influence of a potent poison; a violent tetanic convulsion occurred, in which the body became quite rigid, the extremities violently extended, the hands firmly clenched, the lips puffed out and frothy mucus protruded, driven out as it seemed by some enormous force which was producing the total expulsion of air from the lungs; the hands were dark blue, nails blue, face livid, and features horribly distorted; the pulse was very feeble and hardly perceptible. The convulsion soon passed off, with, however, no decided freedom from the tetanoid condition. On endeavoring to remove his boots, so as to plunge his feet into hot water, violent convulsions were produced, and every indication of agony was manifest on his countenance; his limbs were so firmly and stiffly extended, that it was impossible to do more than semiflex them, although the toes were somewhat limber; after the feet were in the hot water some five or six minutes, there was a relaxation of the spasms, but the tetanoid condition gradually came on again, and a most violent paroxysm ensued. There was considerable frothing at the mouth, complete opisthotonos, lividity of the face, entire cessation of respiration and movements of the heart; he was thought dead for the moment by all around him; gradually, however, the circulation seemed to be re-established, and the respiration to become easy and regular. Soon, however, the tetanic symptoms again presented themselves, and another, though less violent, attack was experienced. There would be slight intervals, lasting for a few minutes, of freedom from spasmodic action, and then a recurrence of spasm, until, finally, a violent convulsion ensued, in which the body became very rigid, the extremities violently extended, face livid, changing to a pale and bloodless hue, eyelids opened widely, and the pupils dilated; the paroxysm was protracted longer than any preceding it. All efforts to overcome the spasm were in vain. Death ensued in somewhat less than three hours and a half after the poison had entered the stomach, 66.
Seized with a violent tetanic spasm, affecting the legs and muscles of respiration, and had only time to call out for assistance before the sensation amounted to that of absolute suffocation (ten minutes after second dose). Spasms now followed each other in rapid succession, the intervals being about a quarter of an hour or twenty minutes, and the affection was confined principally to the legs, back, and respiratory muscles, the arms being comparatively unaffected. The numbness and dragging of the muscles, which had been continuous during the first five hours, disappeared entirely during the intervals of the spasms, and the patient was left without any uneasy sensations, excepting the exhaustion of the previous fits and the apprehension of its successor. During the whole of this time he was not only perfectly conscious, but his senses were preternaturally exalted, and he distinctly heard a variety of whispered observations of the physicians and his friends. The paroxysms, after continuing for some time, began gradually to diminish, the intervals became longer, and the duration of each spasm shorter, and it was hoped that they were about to pass off, when all at once they returned in their original violence. This proved, however, to be the last expiring effort of the poison for the symptoms now entirely ceased, about thirteen hours after the first dose was taken. At the conclusion of the spasms, the patient was left in an excessively exhausted state: from this, however, he recruited with great rapidity, 36.
The spasms ceased at times, during which the circulation improved, the cyanosis disappeared, and consciousness returned, 188.
Whole body rigid, 144, 158.
Rigidity of the body, alternating with violent spasms, 77.
The whole body suddenly became stiff and rigid, with momentarily threatening suffocation, 4. [1040.]
The whole frame rigid, except the arms and hands, which she could exert with comparative freedom and ease. The muscular system generally was on the stretch. The legs were stiff, and the feet drawn down and fairly bowed; the thumbs slightly drawn in, presenting the appearance of carpo-pedal spasm. The muscles of the chest and throat, and especially the latter, were in active play, as though laboring to overcome some powerful obstacle to the admission of air to the lungs; an exquisite sensitiveness of the nerves of sensation, 64.
Stiffening in the muscles generally, especially in the legs from the knees upwards, and in the left hand (eleventh day), 128.
She was found quite stiff, her eyes staring, and her hands clenched, 137.
Muscles rigid, 31.
Muscles of the body generally, but especially of the legs, very hard, 136.
Extreme rigidity of the whole muscular system. The abdominal muscles and those of the lower extremities where more rigid than those of the thorax and upper extremities, 158.
Muscles powerfully contracted, 97.
The whole body became rigid, immovable, and bent backward and towards the right side, 108.
Stiffness of muscles and inability to move limbs (after three hours), 128.
All muscles of body rigid and extended, and body bent backwards at a considerable curve, (after twenty minutes), 30. [1050.]
Whole muscular system rigid; muscles of the back, and of the upper and lower extremities, rigidly contracted; head drawn back; articulation difficult (after twenty minutes), 39.
It was found impossible to produce any relaxation of the body during a fit; the head was firmly bent back, the hands were clenched, the arms bent, the legs and body extended, and if moved she remained in that fixed position, 40.
Whole muscular system rigid; the muscles of the back and legs so rigidly contracted that it was with extreme difficulty that my patient could walk (after twenty minutes), 42.
The whole frame rigid and straight, or slightly curved backwards, and although expressing a wish to be raised to a sitting posture, apparently that he might breathe easier, yet an attempt to elevate his head, which was low and drawn back (there being slight opisthotonos), and the neck rigid, excited spasms, so that he begged us to desist, 63.
Lying on back in bed; hands clenched; forearms flexed; one leg extended, the other in the act of being so, convulsed; head drawn back, 32.
Lying on his back, with his upper and lower extremities extended and rigid (after three hours and three-quarters), 50.
Lying upon his back; his legs stretched wide apart; toes bent upon the bottom of the feet, 43.
He lay upon his back; arms extending obliquely from the body, 121.
Outstretched, without consciousness; jaws clenched; respiration very difficult, 117.
Head bent backward and body rigid, 4. [1060.]
Body bent backward, 3.
Slight opisthotonos, 141.
Opisthotonos, 23, 72, 132.
Opisthotonos; the muscles of the spine are hard and rigid, like cords, the arms outstretched, the hand clenched, 76.
Well-marked opisthotonos, the head being drawn very much backwards, 130.
Great opisthotonos, 27a.
Complete opisthotonos, 75.
Weakness, 23.
Extreme weariness, in the morning (fifty-third day), 123.
Trembling, powerless state of body (forty-third day), 128. [1070.]
Extreme weariness (several days), 128.
Extreme weariness and lassitude, in the morning (twenty-sixth day), 128.
Extreme weariness and yawning, in the afternoon (twenty-third day), 126.
Great weariness and prostration (sixth day), 128.
Great weariness with the giddiness and nausea (third day), 128.
Great prostration after the spasms, 49.
Prostration succeeded to excitement (after eighteen hours), 132.
Collapsed appearance, 232.
Faintness, during which the patient said it seemed as though electric shocks passed from the nape of the neck to the forehead, 13.
Restlessness (after second powder), 128. [1080.]
Exceedingly restless (after fifteen minutes), 30.
Extreme restlessness, with complete consciousness, 23.
Restlessness, with profuse perspiration (forty-fourth night), 128.
Hyperæsthesia and shrinking from currents of air (after seven hours), 101.
Excessive hyperæsthesia, 118.
Extreme sensitiveness to external impressions; a moderate noise or the slightest touch affected her most disagreeably, 28.
Sensation acute, 63.
The contact of the slightest breeze becomes painful, and that of a solid body produces shuddering and spasmodic movements, 63.
Great sensibility of the cutaneous surface to cold, so as to shrink convulsively from the least wind, and to start convulsively at the slightest noise, 28.
Extremely sensitive to the slightest touch or noise; every little noise appeared to beat at the back of the brain (thirty-first day), 128. [1090.]
She felt extremely sensitive to the slightest touch; if the foot was touched, it jumped as though it was shot off (twenty-seventh day), 128.
The sensation of touch is made painfully acute, and the slightest touch of a foreign body at once produces convulsions more or less powerful. The effort to raise an eyelid has produced a spasmodic action which seemed to run through the whole system with electric rapidity, 63.
The organs of special sense became peculiarly sensitive, 63.
The sensitive nerves seemed to convey abnormal impressions, for while the surface was hot to the feel, she at first complained of coldness; subsequently, however, the sensation was of heat, yet she described the feeling as numbness, 63.
Nervous, agitated feeling (twenty-fourth night), 128.
Sudden stiff sensation in the muscles generally, especially of the legs and abdomen, with extreme soreness (forty-seventh day), 126.
A convulsed, stiffened, and twisted feeling, at one moment in the arms and hands, at another in the muscles of the face, a feeling as though the arms were snatched back when taking hold of anything; these sensations lasted for about three hours and then suddenly passed off; she felt all the time as if she would have a "fit," though she never had anything of the kind (seventeenth day), 128.
Feels stiff all over (after twelve hours), 43.
The child screams with pain during the spasms, 148.
Great pain (after one hour), 69. [1100.]
Cramp pains, 92.
Dried-up feeling all over the surface of the body, 43.
Dead numbness all through the limbs and body, 43.
A feeling of stagnation in or a powerless numb feeling throughout the entire body (fiftieth day), 128.
Powerless sensation in the entire body (twenty-seventh day), 128.
Felt slightly indisposed, the most prominent symptom being a sense of numbness in the back of the legs (soon); the symptoms suddenly increased, the numbness being accompanied by a sense of want of power, and a sort of dragging of the muscles of the leg, which soon became so great that, as he described it, he had to put his hands at the back of his thighs in order to push his legs along. As he was in the midst of describing the effect upon his muscles, and bending himself so as to show how it occurred, he suddenly overbalanced and fell heavily backwards (after two hours and a half), 35.
On rising, in the morning, intense soreness in the muscles generally, especially of the legs and back (fifteenth day), 128.
Peculiar sudden faint sensation, with a sense of extreme brilliancy of vision (after three hours and a quarter, fifth day), 128.
Tremulous feeling, with giddiness at intervals, in the afternoon (nineteenth day), 128.
Trembling, faint feeling, with sudden heat down the spine, at night (seventeenth day), 128. [1110.]
Slight general convulsive shocks (forty-third day), 128.
Sudden jerks of the entire body when falling asleep (forty-third night), 128.
Jerkings quite similar to electric shocks, 23.
Sharp darting pain in the muscles at intervals (forty-seventh day), 128.
Shooting pain in all the muscles generally (second day), 128.
All the pains are more of a cramplike nature than rheumatic; they make her feel as though she would be stiffened (fourth day), 128.
While sitting, suddenly a kind of spasmodic jumping in the lower part of the trunk, and now and then in the left arm (after six hours and a quarter), 128.
In the evening the soreness and aching of the whole body became much worse, with intense aching in the back and behind the ears, especially the left half of the back about the waist (fifteenth day), 128.
Felt very much shaken, in the morning (twenty-eighth day), 128.
All symptoms greatly aggravated, at night (forty-first day), 127. [1120.]
She felt herself altogether worse between 8 and 10, in the evening (third day), 128.
On rising, in the morning, felt much better, 128.
(Felt much better in herself, in the morning; the head and eyes seemed free, which had not been the case the entire week), (eighteenth day), 128.
(Since taking the last dose, on the thirty-seventh day, she has felt much better in herself), (fortieth day), 128.
All the symptoms declined in half an hour, 104.

SKIN

Objective.
Skin at first pale, became at last bluish, the face puffy and dark violet, the lips dark blue, the neck swollen, and the jugular veins distended, 108.
Skin livid, and complete redness of entire surface, 141.
The skin of the body became bluish, the capillary vessels filled with venous blood, 4.
Subjective.
Feeling of "burning all over" (after thirty minutes), 123.
Sensation of burning, itching, sticking, as of large pins in the skin, 33. [1130.]
Prickling in the extremities, 78.
Prickly sensation in the feet at intervals (forty-sixth day), 128.
In the place where the drug is rubbed in there are violent burning, sticking, and increased warmth, 29.
Formication of the extremities, 72.
Formication over the arms and lower extremities, 75.
Formication of the tips of the fingers, 5.
Intense itching of the skin of the entire body, even of the scalp (fourteenth day), 128.
Troublesome itching of the skin for about two hours (sixteenth day), 127.
Itching of the skin generally, more particularly of the legs and arms (thirty-fourth night), 128.
Intense itching of the skin (thirty-seventh, forty-first, and fifty-second days), 128. [1140.]
Intense itching of the skin, at night (forty-third day), 128.
Intense itching of the entire skin, lasting for several hours (fifty-third day), 128.
Intense itching of face, ears, and neck, at night (forty-fifth day), 128.
Intense itching of face, arms, and legs (fiftieth day), 128.
Itching of face, arms, and legs (forty-seventh day), 128.
Violent itching of the legs (twenty-first and twenty-fourth nights), 128.

SLEEP

Sleepiness.
Yawning and extreme weariness, in the afternoon (twenty-third day), 128.
Extreme drowsiness and chilliness (second day), 128.
General drowsiness, lasting for some hours (third day), 127.
Sudden drowsy sensation, at 11.30 A.M. (sixth day), 128. [1150.]
Extreme drowsiness, with stupid headache (fifteenth day), 128.
Drowsiness and loss of memory, with extreme giddiness (seventeenth day), 128.
Drowsiness and extreme dulness (twenty-fifth day), 128.
Drowsiness, with a shattered sensation in the head (thirty-third day), 128.
Extreme drowsiness and yawning (thirty-fourth day), 128.
Extreme drowsiness (thirty-fifth and forty-sixth days), 128.
Sleeplessness.
Sleeplessness, with internal uneasiness, anxiety, and oppression, so that she was unable to sleep, 24.
Sleeplessness caused by dread of the rectal spasms, 127.
Sleeplessness, visions of dead persons (first day).
Very sleepless night (twenty-seventh day), 125. [1160.]
Sleepless night (first and second night), 127.
Has not slept at all during the night, 43.
Not at all drowsy, rather the opposite, 43.
Extreme restlessness and talking in her sleep, accompanied by a peculiar working in the back of the brain (twentieth night), 128.
Restless nights, with profuse perspiration, since the last dose, the twenty-fourth day (twenty-seventh day), 128.
Restless nights and profuse perspiration since taking the last dose, on the thirty-first day (thirty-fourth day), 128.
Very restless night (forty-fifth day), 128.
Rest bad (forty-seventh day), 127.
Great restlessness (fifty-fourth night), 128.
At night, disagreeable dreams; strange wanderings of the imagination (sixth day), 128.

FEVER

Chilliness. [1170.]
Extreme chilliness (several days), 128.
Extreme chilliness and drowsiness (second day), 128.
Peculiar creeping chilliness all over, with a tremulous sensation in the jaws (third day), 128.
Extreme chilliness, even in a warm room (fourth day), 128.
Extreme chilliness and drowsiness (twenty-fifth day), 128.
Slight shivering (twenty-second day), 127.
Shivering, 6, 23.
Shaking chill, 75.
Icy coldness all over, with shivering and yawning (eleventh day), 128.
General coldness, especially in the sacral region, which feels as if iced (twenty-third day), 127. [1180.]
Icy coldness of the entire body (twenty-eighth day), 128.
A feeling of coldness suddenly came over him; he shivered all over, and his limbs became quite rigid, 142.
Whole surface of body quite cold, 139.
Surface cold, 47, 69.
Skin rather cool (after one hour and a half), 45.
Skin cold and clammy and of a dark livid hue, 147.
Painful coldness of the head, at 3.30 P.M. (seventh day), 128.
Peculiar creeping chilliness, with heat, in the right side of the head and face (first day), 128.
Cold chills passing over the head and down the back (forty-third day), 128.
Icy coldness of the head and down the spine (sixteenth day), 127. [1190.]
A single cold chill down the entire length of the spine; afterwards she felt deathly cold (third day), 128.
Icy coldness down the spine, accompanied by a kind of nervous shuddering (fourteenth day), 128.
Icy coldness down the spine (fifteenth day), 128.
Cold chills down the spine, at night (twenty-fifth day), 128.
Cold chills down the back, frequently (twenty-first night), 128.
Cold chills down the back (twenty-ninth and thirty-second days), 128.
Coldness of back (fifty-second night), 128.
Extremities cold, 88, 124, 126, 129.
Extremities cold and rigid (after six hours), 130.
Arms and legs cold (after three hours and three quarters), 50. [1200.]
Lower extremities cold, and perspiration flowing in a stream from his head and chest (after twenty minutes), 42.
Feet cold to touch, 43.
Heat.
Fever of an adynamic intermittent type (such as I have frequently witnessed in Peshawar, on the northwest frontier of India), with considerable prostration, during these seven days (thirtieth day), 127.
Slight fever caused by dread of the rectal spasms, 127.
Began to get hot during the spasms, 136.
Temperature of the body higher than usual, between the paroxysms, 57.
Suffering from heat, 66.
Temperature 100 (after seven hours), 161.
An intolerable sense of heat complained of over the entire body, although on same parts cool to the feel, so that he could not bear the slightest covering, 63.
Burning heat all over, with a hot sweat, 43. [1210.]
Skin warm, and covered with a profuse clammy sweat, 82.
Body warm, but hands and feet rather cold (after one hour), 94.
Increased warmth of the body, 3.
Sensation of warmth starting from the abdomen and spreading over the whole body, and ending with general profuse perspiration, 3.
Burning heat and great fulness in head, 43.
Heat and intense pain in the head, 43.
Sudden burning heat in the face (twenty-seventh day), 128.
Sudden heat down the spine, with trembling faint feeling, at night (seventeenth day), 128.
Sweat.
Perspiration rolling off him, 121.
Profuse perspiration, with restlessness (forty-fourth night), 128. [1220.]
Profuse perspiration, with relief of the symptoms, 29.
Perspiration flowing profusely from the face and chest (after twenty minutes), 39.
Profuse sweat after the spasm, 49.
After the attack subsided, very copious sweating ensued, 86.
Profuse perspiration during sleep (forty-seventh and forty-eighth days), 127.
Skin bathed in perspiration, warm (not hot) and uniformly so, 63.
Surface bathed in perspiration, 82.
Body bathed in warm perspiration (after seven hours), 161.
The skin was bedewed with perspiration, and the capillary circulation congested, so as to give an unusual floridness to the complexion on the upper part of the forehead, amounting to a slight bluish or purplish color, 64.
Regularly recurring perspiration, 2. [1230.]
Large drops of perspiration on the face, and matting of the hair, arising from profuse perspiration, 155.
Perspiration of the chest became excessively violent, 108.
Skin covered with cold sweat, 88, 122.
Cold sweat, 145.
Sudden cold perspiration and icy coldness of the entire body (twenty-fourth day), 128.
Cold perspiration, with the convulsive shocks and increased shaking and stiffening (forty-first day), 128.

CONDITIONS

Aggravation.
( Morning ), Headache; griping pain in bowels; weariness.
( Evening ), Thumping pain in head.
( Night ), Toothache; symptoms.
( Bending head down ), Stiff sensation up the spine.
( Exertion ), Pain in back.
( After meals ), Oppression of chest.
( Noise ), Tetanic spasms.
( Opening mouth ), Jerking sensation in stomach; jerks in back.
( Sitting on hard seat ), Uneasiness about bladder and urethra.
( After sitting ), Stiffness of muscles of legs.
( After standing ), Aching and stiffness in back.
( Touch ), Twitching of muscles; spasms; violent convulsions.
( Walking ), Uneasiness about bladder and urethra; burning in urethra; aching and stiffness in back; aching in shin bones; aching in feet.

SUPPLEMENT: STRYCHNINUM. Authorities.

162 , R. Gilsan, Amer. Journ. of Med. Sci., New Ser., No. 150, 1878, p. 449, a man, æt. twenty-five years, took a dose; 163 , V. R. Bridges, M.D., Chicago Med. Journ. and Exam., 1879, p. 48, a girl, æt. nine years, took an unknown quantity.

I found him in terrible tetanic convulsions. His legs and arms were extended, hands clenched, feet and toes incurvated, and his body was rigidly arched backward, and resting on his heels and back of his head. In short, all his muscles seemed to be in a state of rigidity. There were also the risus sardonicus , and a general cyanosed appearance of the skin. During the paroxysm the pulse was too frequent to be counted, and his pupils were slightly dilated. It was impossible on account of trismus and the violence of the general spasms, to administer an emetic by the mouth or to use the stomach-pump. The next morning I found him well, but still feeling some muscular soreness and fatigue, and fully resolved to let Strychnia alone in the future. He said no one could imagine the fearful agony it had caused him, and that he would rather be burnt to death than again suffer the pangs that he had endured from this horrible poison. He told me also that after taking the Strychnia he locked the door of his room, and lay down on his bed to die, as he supposed, in a rapid and easy manner. When the spasms commenced they soon put him in such fearful agony that he screamed for help, 162.
Continuous and persistent spasm from head to foot, with an alarming and distressing opisthotonos, rendered all the more painful from the fact that she was entirely unconscious of her sufferings, while any effort to relieve her by the slightest touch, or causing her to swallow, only aggravated her condition, by apparently exciting every muscle to increase its tension, 163.

Strychninum