An alkaloid, obtained from several species of Strychnos, especially from Strychnos nux vomica, L.

Formula

, C21H22N2O2

Preparation , Trituration of the alkaloid, or solution of its salts.

Authorities. ( 1 to 18 , from Noack and Trinks.)

1 , Andral, in Magendie, Journ. de Physiol., July, 1823; 2 , Hirl, in Dierbach's Neuesten Entd., 2, p. 536; 3 , Richter, Preuss. Med. Vereins-zeitg., 1834, 36, vom salpeters Strych.; 4 , Blumbach, Würtemb. Med. C. Blatt., 1837, 1, bei einem 17 Jähr Burschen v. 2 scrupel Strychn. pur.; 5 , Burdach, Preuss. Med. Vereins-zeitg., 1837, p. 115; 6 , Weyland, Casp. Wochenschr., 1840, 24, vom Strychn. nitr.; 7 , Behrend, Preuss. Med. Vereins-zeitg., 1840, vom Strychn. nitr.; 8 , Beck, Würtemb. Med. C. Blatt., 1844, Nr. 25; 9 , Provinc. Med. and Surg. Journ., 1845, December; 10 , Schmidt, Preuss. Med. Vereins-zeitg., 1845, 9; 11 , Sichel, Annal. d'Oculist, 1846; 12 , Theinhardt, Casp. Wochenschr., 1846, Nr. 9; 13 , Huss; 14 , Civinni; 15 , Oppler; 16 , Pritzou; 17 , Trousseau and Pidoux; 18 , Carron de Villard; 19 , Dufresne, Bibliothèque Homéopathique (Lond. Med. Gaz., vol. 10, 1832), a lady, æt. 40 years, took for facial neuralgia a hundred millionth of a grain of Strychnine; 20 , Philalethes, Lancet, 1834-5 (1), p. 256, a woman took five pills containing an unknown quantity of Strychnine; , Dr. Epps, Lancet, 1836-7 (1), p. 133; , Dr. Wegeler, Casper's Med. Woch., 1840 (A. H. Z., 19, p. 222); , same, Nitrate of strych.; , Wehand, Casper's Med. Woch., 1840 (A. H. Z., 19, p. 223), a woman, æt. 35 years, subject to epilepsy, took 3 grains; , Ludicke, Journ. für Pharm., 4, p. 199, a woman, æt. 40 years, took 1/24 grain Nitrate every three hours, then 1/12 grain six times in succession; , Schmied, Schweizer's Zeit. für Nat. und Heilk., vol. 6, 1841 (Journ. für Pharm., 4, p. 199); , Scheible, Annal. des Staats-arzneik., etc., 1843 (Brit. Journ. of Hom., 3, p. 61), death of an apothecary; , Fohr, Zeit. Für Rat. Med., 1844 (Journ. für Pharm., 4, p. 199), a man, æt. 60 years, took of a solution of 2 grains Acetate to 1 ounce, 15 drops three times a day, increasing by 2 drops daily, until at last he took 40 drops at a dose; , Wimmer, Neue Med.-Chir. Zeit., 1844 (A. H. Z., 28, 158), effect of inunction of a much as 1/4 grain Strychnine in the temporal region; , James Watson, Lond. Med. Gaz., 1846, fatal poisoning of a girl, æt. 13 years, by three pills, each containing 1/2 grain; , Prov. Manchester Courier, abridged in Dublin Med. Press, 1846 (Month. Journ. Med. Sci., vol. 6, p. 141); , Comach's Month. Journ., February, 1846, p. 141 (Guy's Hosp. Rep., 1856 (2), p. 348), a woman, æt. 35, took 3 grains of powder in tea, death in three-quarters of an hour; , Cattell, Brit. Journ. of Hom., vol. 11, p. 173, Nitras; , Report of Drs. Allen, D. Warner, and Russell, on death of Dr. William Cullen Warner, Bost. Med. and Surg. Journ., vol. 36, 1847, p. 209; , Hampshire Independent (Lancet, 1848 (2), p. 543), Mrs. S. swallowed some Strych., death in an hour and three-quarters; , Dr. Thomas Anderson, Am. Journ. of Med. Sci., 1848 (1), p. 563, a man took 3 1/2 grains for tic douloureux, and five hours later a second dose; , Pharm. Journ., vol. 8, 1848-9, p. 298, a woman took 3 grains in liquid, death in an hour and a quarter; , A. B. Shipman, Bost. Med. and Surg. Journ., vol. 41, 1849, a medical gentleman took 1/4 grain of Sulphate; , A. W. Munson, Bost. Med. and Surg. Journ., vol. 42, p. 43, Mr. G., æt. about 40 years, swallowed probably 1 or 2 grains of Strych.; , George Bennett, Lancet, 1850 (2), p. 259, Amelia H. took 5 drachms of a solution of 10 drachms of cinnamon-water and 3 grains of Strych.; , Jahrbuch für Prakt. Pharm., 1850, vol. 21, a boy, æt. 7 years, having worms, was given Strych. instead of Santonin; , Dr. Dresbach, Western Lancet, 1850 (Am. Journ. Med. Sci., New Ser., 19, 1850, p. 546), a man, æt. 24 years, took 3 ounces of a solution containing 1 grain to the ounce; , Edward G. Bartlett, M.D., North Am. Journ. of Hom., vol. 1, 1851, p. 469, a man, æt. 22 years, took 3 grains dissolved in water; , J. C. Foster, M.D., Lancet, 1852 (2), p. 33, S. S., æt. 52 years, swallowed a solution containing 1 grain; , I. Pidduck, M.D., ibid., p. 80, a man took two doses of 1/6 grain in sugar; , T. Hillier, Med. Times and Gaz., 1854, p. 316, A. B., æt. 18 years, took 2 grains; , Henry Lonsdale, M.D., Lond. and Edinb. Month. Journ., 1855, p. 116, death of a man, æt. 59 years, in an hour after 1 1/2 grains; , Pharm. Journ., vol. 15, 1855-6, p. 478, poisoning of a woman æt. 28 years; , G. J. Hinnell, Med. Times and Gaz., 1855, p. 413, T. M., æt. 33 years, ate 4 to 5 grains on bread; , J. J. Lescher, M.D., Am. Journ. of Med. Sci., New Ser., 29, 1855, p. 269, E. W., æt. 30 years, took 4 grains after a hearty breakfast; , F. Ryland, Assoc. Med. Journ., 1856, p. 500, a man took 1 1/2 grains, death in five hours; , Dr. Geoghegan, Dublin Med. Press, June, 1856 (Guy's Hosp. Rep., 1856 (2), p. 352), a man took 5 grains, death in twenty to twenty-five minutes; , A. S. Taylor, M.D., Guy's Hosp. Rep., 1856 (2), 352, John Parsons Cook took an unknown quantity, death in one hour and a quarter after last pills; , Drs. Lawrie and Cowan, Glasgow Med. Journ., July, 1856 (Brit. and For. Med.-Chir. Rev., 1856 (2), p. 407), a man, æt. 22 years, took 3 grains; , Dr. Stevens, ibid., a man in the habit of taking 1/8 grain in solution twice a day took more than the usual quantity; , Dr. Bruce, ibid., a man took 4 grains in solid form; , G. M. Jones, Esq., Lancet, 1856 (2), p. 302, Jane D. took 1/2 grain commercial Strych; , Times, February 18th, 1857 (Pharm. Journ., vol. 16, 1856-7, p. 485), William Gummow took 3 grains; , T. W. Craster, Lancet, 1856 (2), p. 107, a woman took 1/4 grain; , R. W. Martyn, ibid., p. 117, a lady, æt. 45 years, took 1/4 grain; , James Campbell, ibid., p. 695, Mrs. M. took an unknown quantity; , same, a man, æt. 30 years, took about 10 grains; , Morse Stewart, M.D., Peninsular Med. Journ., October, 1856, p. 186, a man, æt. 45 years, took a quantity; , same, Mrs. E. A. P. took from 5 to 15 grains in water or ice-cream, death after five hours; , Lewis H. Steiner, M.D., Trans. Am. Med. Assoc., vol. 9, 1856, p. 755; , same, Dr. George A. Gardiner swallowed a paper package containing commercial Strych. or a mixture of Strych and Brucia; , James Kirk, M.D., Med. Times and Gaz., June 14th, 1856, p. 609, a young man took, it was supposed, 6 grains; , Med. Times and Gaz., August 23d, 1856, poisoning of a child; , R. Adams, ibid., Mr. D., æt. 65 years, took 20 grains; , ibid., p. 274, Mrs. Harriet Dove, æt. 28 years, took Strych. in jelly; , S. A. Gus. Shaw, M.D., Am. Journ. of Med. Sci., New Ser., 31, 1856, p. 547, a woman, and a child 2 years old, ate the Sulphate on dried beef; , Tarchini-bonfanti, Gaz. Lomb., 1856 (S. J., 91, p. 300), poisoning of a man, æt. 45 years; , Palmer, Arch. Gen., July, 1856 (ibid.); , Perini, S. J., 91, p. 302, a person took 3 grains; , Gaz. Med. Italian, from Gaz. Méd. de Paris, 1856 (Zeit. für Verein Hom. Aust.), poisoning by an indefinite amount; , Hencke's Zeit. für Staät, 1856 (Zeit. für Verein Hom. Aust.), case of poisoning; and , same, others cases; , Rochester, Am. Journ. of Med. Sci., October, 1856 (Brit. and For. Med.-Chir Rev., January, 1857), a man, æt. 32 years, took 4 grains; , John H. Claiborne, M.D., Virginia Med. and Surg. Journ., 1857, p. 460, a man, æt. 30 years, took a quantity in water; , G. W. Arnett, M.D., Charleston Med. Journ. and Rev., vol. 12, 1857, p. 86, a man, æt. 28 years, took a quantity; , H. O. Jewett, M.D., Bost. Med. and Surg. Journ., vol. 56, 1857, p. 491, a boy æt. 15 years, took probably 2 grains; , Dr. McClintock, Dublin Med. Journ., 1857 (2), p. 215, a boy, æt. 16 years, took 11 grains spread on bread and butter; , H. L. Givins, M.D., Am. Journ. of Med. Sci., 1857 (1), p. 63, a young man took 10 or 12 grains; , George Hodgetts, Pharm. Journ., vol. 16, 1857, p. 389, Mr. M. took 4 grains; , Ernest P. Wilkins, Lancet, 1857 (1), p. 551, Mr. G., æt. 23 years, took 3 grains on a biscuit, death in six hours; , J. R. G., New Orleans Med. News and Hosp. Gaz., 1858, p. 451, Mrs. L. G., an elderly woman, took a large dose; , same, a few days later took another dose; , J. F. Ogilvie, M.D., Med. Times and Gaz., October, 1858, p. 443, M. C., æt. 21 years, took 4 grains, after drinking largely of pure brandy the previous evening; , Thomas O'Reilly, M.D., Med. Times and Gaz., January, 1858, p. 600, Mr. Johnson took 6 grains in beer; , Douglass A. Reid, Med. Times and Gaz., December, 1859, p. 663, Mr. S. allowed the mouth of a bottle containing Strych. to touch an abrasion of the cuticle of last phalanx of thumb; , Douglass Bly, M.D., New York Med. Journ., 1859 (2), p. 423, a man took 4 grains; , Mr. T. Orton, Pharm. Journ., 1859, p. 245, a girl, æt. 16 years, died from effects of Strych.; , Dr. Davies, ibid., p. 247, Robert. G. Visick died from Strych.; , Dr. S. S. Harris, Am. Med. Times, vol. 1, 1860, p. 100, Thomas W., æt. 28 years, took 6 or 8 grains; , J. B. Dunlap, M.D., Med. and Surg. Rep., 1860, p. 227, Miss S. R., æt. 24 years, swallowed 4 grains; , Pharm. Journ., July, 1860, a girl, æt. 11 years, took Strych., death; , J. R. Smith, Am. Journ. of Med. Sci., New Ser., vol. 40, 1860, p. 278, a man took an unknown quantity; , L. A. Lawrence, Lancet, 1861 (1), p. 571, a woman, æt. 30 years, took an unknown quantity; , George Harley, M.D., ibid., p. 480, W. B. Carleton describes the case of a boy, æt. 12 years, who took 3 grains in a pill, death; , George Harley, M.D., ibid., p. 397, a girl, æt. 11 years, took an unknown quantity of pure Strych.; , Dr. Henrie, Brit. Med. Journ., 1861 (2), p. 400, a child, æt. 4 years, took the powder in preserves, death in half an hour; , Dr. M. Schuppert, New Orleans Med. Times (Med. Times and Gaz., 1861 (1), p. 499), poisoning of a man; , Dr. Langenbeck, Gaz. de Paris, 1861 (S. J., 112, p. 171), 6 milligrams were injected into lachrymal gland, in a man suffering from amaurosis; , Schüler, Gaz. de Paris, No. 6, 1861 (Syden. Year-book, 1861, p. 427), 1/10 grain was introduced, without result, at various times into the eye of a man æt. 50 years, who had suffered from amaurosis, then 1/20 grain was injected into lachrymal canal; , Martius, Memorabilien, 1862, p. 67 (S. J., 131, 235); , Lancet (Brit. Journ. of Hom., vol. 20, 1862, p. 173), poisoning of a woman, æt. 28 years; , J. B. Wilmot, M.D., Med. Times and Gaz., March, 1862, p. 250, poisoning of a girl æt. 18 years; , Blumhardt, Wurt. Corr.-Blatt., vol. 7, No. 1, 1863 (Journ. für Pharm., vol. 4, 199), a boy, æt. 17 years, took about 2 scruples; , Dr. Laukester, Pharm. Journ., 1863, p. 378, George Heimsath, æt. 43 years, drank beer containing Strych., death; , same, Collis drank a small quantity of same, recovery; , W. D. Buck, M.D., Am. Med. Times, vol. 7, 1863, p. 205, Mary Ann Gibney took a quantity of Strych.; , Dr. Frankel, Vjs. für Ger. Med., 1864 (S. J., 131, 235), a man took 5 or 6 grains; , Genets de Serviere, Gaz. Heb. Dom., 1864 (S. J., 131, 235), a woman was poisoned; , same, second case; , Joseph Wilson, M.D., Am. Journ. of Med. Sci., New Ser., 48, 1864, p. 70, a man, æt. 22 years, took probably 40 grains; , George T. Barker, Am. Journ. of Med. Sci., New Ser., 48, 1864, p. 399, poisoning of a woman; , Bertholle, Am. de Hyg., 1865 (S. J., 131, 235), poisoning of a man; , Norman Cheevers, M.D., Indian. Annals of Med. Sci., 1866 (Ranking's Abstract, 1866 (2), p. 225), a girl, æt. 11 years, swallowed an unknown quantity; , Dr. Tracy E. Waller, Phila. Med. Reporter (Pharm. Journ., 1866, p. 533), Dr. --- swallowed 4 grains in water, taking several drinks of whisky before and two afterwards; , S. A. McWilliams, M.D., Chicago Med. Exam., 1866, p. 726, Mrs. T., æt. 31 years, took 5 grains; , Dr. Maschka, Prag. Vjs., 1867 (S. J., 137, 293); , Holmes Coote, Brit. Med. Journ., 1867, p. 513, a woman, æt. 40 years, took 3 minims; , Julian S. Sherman, M.D., Chicago Med. Exam., 1867, p. 138, Charles W., æt. 23, took 2 grains; , omitted; , Stacy Hemenway, M.D., Chicago Med. Exam., 1867, p. 528, James G., æt. 28 years, took a quantity in milk; , Henry Robinson, Month. Hom. Rev., vol. 12, 1868, 252, R. R., æt. 29 years, robust and very healthy, took in all about 7 1/2 grains of Liquor strych. (off. prep.), 20 drops in a tumbler of water, in two doses, one in the morning, one in the evening (first day), 30 drops in three doses (second day), three doses of 12, 15, and 10 drops (third day), four doses of 10 drops each (fourth, fifth, sixth, and seventh days), 48 drops in four doses (thirteenth, fourteenth, and fifteenth days), 60 drops in four doses (sixteenth day), 60 drops in three doses (seventeenth day), 60 drops in four doses (eighteenth to twenty-second day), occasional doses of laxative medicine as required (after twenty-three days), took Camphor and Gum arabic (forty-first day), 1/6 grain of Morphia twice, 20-drop doses of Hyoscyamus, and a large quantity of Linseed tea (forty-sixth day); , same, A. F., a woman, æt. 34 years, very healthy, took 15 drops in a wineglass of water (first day), 20 drops as before (fifth day), 25 as before (eleventh day), 30 as before (fourteenth, seventeenth, twenty-first, twenty-fourth, twenty-seventh, thirty-first, thirty-fourth, and thirty-seventh days), 35 as before (forty-first day), 30 as before (forty-third and forty-seventh days), 445 drops in fifty-three days; , Most's Denkwurdig., 1, 147 (Hom. Exam., vol. 3, 1844), a boy, æt. 4 years, took 4 grains every three hours; , Med. Times and Gaz., 1868 (1), p. 499, poisoning of a child; , James T. Newman, M.D., Med. and Surg. Rep., vol. 20, 1869, p. 234, Miss Kate Pindar took two pills of Strych.; , Tardieu and Roussin, Ann. d'Hyg., 34, p. 128 (Syd. Year-book, 1869-70, 461), a woman survived 15 grains for eighteen hours; , Dr. Keyworth, Glasgow Med. Journ. (Pacific Med. and Surg. Journ., 1869, p. 569) a woman took 3 grains; , James J. Rooker, M.D., Cincinnati Lancet and Obs., vol. 12, 1869, p. 333, poisoning of Mr. A.; , Med. Times and Gaz., 1869 (1), p. 613, poisoning of a man; , Dr. Cameron, Med. Times and Gaz., 1869 (2), 491, M. A. B., æt. 17, took probably 3/4 grain; , J. H. Grimshaw, M.D., Pharm. Journ., Second Ser., vol. 11, 1869-70, p. 45, a child æt. 1 1/2 years, was poisoned by a powder; , omitted; , C. B. Gillespie, M.D., Am. Journ. of Med. Sci., 1870 (2), p. 420, a man swallowed 2 1/2 grains; , W. W. Hewlett, M.D., New York Med. Journ., vol. 13, 1871, p. 297, a man, æt. 30 years, swallowed 5 grains; , Cephas L. Bard, M.D., Phila. Med. Times, June, 1871, p. 316, a man ate cakes made from flour containing Strych.; , Brighton Daily News (Pharm. Journ., Third Ser., vol. 2, p. 16), Mr. Miller ate sweetmeats containing Strych.; , same, S. A. Baker, æt. 4 years, died from effects of eating same; , Thomas Moore, Lancet, 1872 (1), p. 431, a young man took over a grain; , S. Haughton, M.D., Brit. Med. Journ., 1872 (1), p. 660, a man, æt. 19 years, ate an egg in which some Strych. had been placed; , S. A. Turner, M.D., Med. and Surg. Rep., vol. 26, 1872, p. 529, a Sioux Indian, æt. 45 years, took a quantity of Strych. in food; , E. H. Coover, M.D., Med. and Surg. Rep., vol. 26, 1872, p. 520, Mr. E. R. Burke took 1 grain; , same, account of same as reported by Mr. Burke himself; , Schmid, Memorabilien, 1873 (S. J., 163, 131), poisoning of children; , G. W. Copeland, M.D., Brit. Med. and Surg. Journ., 1873 (2), p. 450, a man swallowed 5 grains; , G. D. O'Farrell, M.D., Phila. Med. Times, February, 1873, p. 311, J. W., æt. 50 years, took 2 grains; , Report of Brooklyn City Hospital, Med. Rec., vol. 9, 1874, p. 345, a person took 5 grains; , Dr. Carbert, Canada Lancet, vol. 7, 1874, p. 10, George Finlayson took 3 1/4 grains; , Dr. C. Bivine, Phila. Med. Times, 1875, p. 720, poisoning of a girl æt. 16 years; , J. B. Sim, Lancet, 1875 (2), p. 310, a woman swallowed 6 drachms Liquor strych.; , J. C. Ogilvie Will, M.D., Edinb. Med. Journ., 1875, p. 907, G. S., æt. 18 years, swallowed not less than 4 grains probably 5 or 6; , W. W. Hays, M.D., Pacific Med. and Surg. Journ., January, 1875, p. 389, a woman took a dose; , H. P. Cole, U. S. Med. Invest., New Ser., 2, 1875, p. 432; , W. F. McNutt, M.D., ibid., November, 1876, p. 251, a middle-aged woman took 14 grains; , Dr. Hippel, Hom. Times, vol. 4, 1877, p. 86, effects of doses of 2 to 4 milligrams; , H. G. Landis, M.D., Phila. Med. Times, October, 1877, p. 6, a man, æt. 29 years, took over 2 grains; , O. G. Shelden, M.D., Med. Rec., vol. 14, 1878, p. 87, A. Manning, æt. 44, somewhat insane, took, it was alleged, between 7 and 8 grains.

MIND

Emotional.
Delirious; she however, possessed sufficient lucidity to state that a certain person had given her a white powder in a glass of wine (after eighteen hours), 132.
She was much like a mad woman all night, 19.
Shouted out, "They are coming for me," 63.
A species of imbecility arising from an excessive acuteness to impressions, 21.
A peculiar nervous erethism, almost resembling what I had seen in a case of hydrophobia several years before. The patient was very much alarmed and excited, slightly delirious, answering questions correctly when asked, but wandering when left to himself, and begged most piteously that I would not hurt him. I was forcibly struck with the very marked resemblance of the delirium in this case to that which I had often seen in mania a potu . The same nervous restlessness and fear of being injured, the same hyperæsthesia and shrinking from currents of air, made the similarity very striking (after seven hours), 161.
Nervous agitated feeling, with sensation of stupor and headache (twenty-first night), 128.
Extreme nervous excitability, ugly face passing before the eyes (twentieth night), 128.
Extreme nervous excitability; she felt light and nonsensical (thirty-seventh day), 128.
Mental condition agitated, but consciousness perfect throughout, 63. [10.]
Excessively nervous and alarmed (after two hours and a half), 36.
Painful nervousness (fiftieth day), 128.
Involuntary idiotic-like chuckle (seventeenth day), 127.
Immoderate fits of laughing (thirty-fourth day), 128.
Fits of laughing, with the light swimming sensation and giddiness (after one hour, forty-first day), 128.
Extreme nervous excitability (forty-first and forty-seventh days), 128.
Screaming, 96.
Loud groans, convulsive sobbing (after fifteen minutes), 167.
Moaning (in fifteen minutes), 52.
Loud moaning (after one hour), 69. [20.]
Constant moaning, with complete consciousness, 77.

HEAD

Confusion and Vertigo.
Confusion and slight giddiness (twenty-seventh day); confusion and slight giddiness, at noon (twenty-eighth day); confusion and giddiness, with slight trembling (after one hour, thirty-seventh day); muddled feeling in the head (thirty-ninth day); confusion in the head, with feeling of intoxication, at night (forty-first day); confusion and loss memory (forty-third day), 128.
Vertigo, 10, 23, 28 , etc. [60.]
Vertigo and inclination to fall forward (after three to four minutes), 104 ; (after a few minutes), 103.
Vertigo, with roaring in the ears, 3.
Excessive vertigo, even while lying down, associated with nausea, 25.
Great dizziness, 152.
Giddiness and nausea, a sensation as if the brain had been overworked, with great weariness (third day); slight giddiness, at intervals (tenth day); sudden giddiness and extreme drowsiness while walking in the street; she felt as if a cloud was coming over her (after one hour, eleventh day); confused giddy feeling, at intervals, with loss of memory (thirteenth day); giddiness (fourteenth day); giddiness, at intervals (fifteenth day); extreme giddiness, with loss of memory and drowsiness (seventeenth day); giddiness, at intervals, with tremulous feeling, in the afternoon (nineteenth day), extreme giddiness, with a tremulous sensation down the back (after three-quarters of an hour, twenty-first day); extreme giddiness (after three-quarters of an hour, twenty-fourth day); giddy bewildered feeling (twenty-seventh day); extreme giddiness (thirty-first day); extreme giddiness, with fixed stiff sensation in the eyes (after half an hour, thirty-fourth day); giddiness; light swimming sensation, with fits of laughing (after one hour, forty-first day); sudden momentary giddiness, with dull pains in the head and eyes, at noon (forty-second day); a feeling of giddiness and stupor (after forty minutes, forty-third day); giddiness; light swimming sensation in the head (after three-quarters of an hour, forty-seventh day); extreme giddiness; light swimming sensation in the head (two hours after first dose, fiftieth day), 128.
Extreme giddiness and confusion in the head (after half an hour, fifty-third day), 129.
General Head.
Jerking of the head forwards (twenty-fourth day), 128.
Head jerked backwards, 154.
Head drawn backward, .

EYE

Objective.
Eyes highly injected, and in constant motion, as from seemingly great affright, as, indeed, his mind fully evidenced (after three hours and three-quarters), 50.
Eyes injected, and protruding, 82.
Eyes a little suffused, 63.
Eyes sunken, 6, 24.
Eyes sunken, and moved with a rapid motion, 89.
Rolling of the eyes, as if they were two cold bullets (twenty-fourth day), 128.
Torsion of the eyes (after second powder), 128.
Eyes turned to one side, quite staring, 78.
The eyes were drawn upward and greatly congested, 147. [130.]
The eyes appeared to be starting from their sockets, the head was forcibly drawn round, the arms and legs horribly convulsed, she being conscious at the same time, 60.
Protruding eyes, 3, 4, 47, 62.
Eyes staring, 158.
Eyes protruding, turned towards the right, and fixed, with dilated, insensible pupils, and red conjunctiva, 108.
Eyes protruding, rigid, turned to the right, 4.
Eyes fixed, and turned upwards, 30.
Dimness of the eyes (third and fifty-fifth days), 128.
Dimness and aching of the eyes (thirty-fourth day), 128.
Subjective.
Dull pains in eyes and head (forty-third day), 128.
Aching and smarting of the eyes, in the afternoon (thirty-sixth day), 128. [140.]
Aching of the eyes, with dull misty vision (forty-third day), 128.
Severe pain in the left eye, at 8 P.M. (second day), 128.
Sudden pain and pressure in the left eye and at the top of the head (twelfth day), 128.
Violent pains in left eye (thirty-fifth day), 128.
Boring sensation in the eyes, especially the left eye (forty-third day), .

EAR

Creeping tingling sensation in the external ears (second day), 128.
Sudden burning and itching of ears, eyes, and nose (fifty-third day), 128.
Burning in the left ear and left eye, in the afternoon (second day), 128.
Sudden burning heat in the left ear, and along the lower jaw of same side, at 10 P.M. (eighth day), 128. [200.]
Intense burning of and bruised feeling in the ears (twenty-second day), 128.
Intense burning and itching of the ears, nose, and eyes (twenty-fourth night), 128.
Burning and tingling in the ears nose, and lips, at noon (twenty-fifth day), 128.
Intense aching behind the ears and down the spine (twenty-fourth day), 128.
Sharp darting pains behind the right ear (twentieth day), 126.
Sharp darting pains in and behind the ears, and back of the head and neck (thirty-sixth day), 128.
Cracking in the ear and jaw; it is very painful to move the jaw, as in clenching the teeth (forty-fifth day), 128.
Digging pains deep in the left ear (eighth day), 128.
A feeling of intense fulness in the ears (second day), 128.
Hearing.
The ears become appreciative of the slightest sound in the room, 65. [210.]
Hearing very acute, and remarks made in a very low tone of voice were replied to quickly, 66.
Roaring in the ears, 29.
Noise in the left ear like wind (seventh day), 128.
Humming in the ears (twenty-third day), 127.

NOSE

Frequent fits of sneezing, with itching and stinging of nose (forty-seventh day), 128.
Peculiar stinging in the nostrils, as if a cold were coming on (thirteenth day), 128.
Burning and tingling in the nose, ears, and lips, at noon (twenty-fifth day), 128.
Sudden burning and itching of nose (fifty-third day), 128.
Intense itching of the nose, as if in the bone, lasting the entire day (second day), 128.
Intense itching and stinging of the nose (thirty-fourth night), 128.

FACE. [220.]

Face swollen and burning hot; I was exceeding surprised at the appearance she presented, in the morning, her eyes were half closed with swelling, and I could only compare them with those of a person stung by bees; but the next evening everything looked favorable, with a decided abatement of the swelling and pain, 19.
Face puffy, covered with perspiration, 75.
Face puffy and red, 76.
Face puffy, pale, distorted, 4.
Face puffy and bluish red, with open mouth, 2, 3.
Face puffy, dark-violet colored, lips dark blue, 4.
The muscles of the face and about the mouth became rigid and drawn, as in risus sardonicus, it became impossible to utter articulate sounds, 108.
Hard stiffness of the muscles of the face (sixth day), 128.
Hard rigidity of the muscles of the face (thirty-fourth day), 128.
Contorted countenance, 62, 42. [230.]
Expression of extreme terror, 49.
Expression of extreme sadness and despondency, 43.
Anxious expression of countenance, 63, 119, 126, 130.
Countenance expressive of intense anxiety and distress, 64.
Countenance extremely anxious (after one hour), 124.
Expression indicative of great suffering, 158.
Expression of countenance hideous (after six hours), 150.
Face exhibiting an almost maniacal expression, 40.
Wild look with dilated pupils and red face, 28.
Face became gradually pale, from above downwards, lips remaining livid, 30. [240.]
Pale sunken look, 62.
Face deathly pale, 6, 24.
Face pale, anxious, 122, 145.
Face pale and distorted, 108.
Countenance pale and blue (after three to four minutes), 104.

MOUTH

Teeth.
Clenching of the teeth, with twisted sensation in the jaws (forty-first day), 128.
Severe toothache, at midnight (third day), 128. [300.]
Violent attack of toothache in the upper teeth, left side, shooting to the cheek-bone (twenty-third day), 128.
Sharp attack of toothache in left half of the teeth (twenty-sixth night), 128.
Toothache in the upper teeth at intervals, a sensation as if the teeth were loose and too long (thirty-second day), 128.
Toothache in the upper teeth at intervals, they feel too long (thirty-third day), 128.
Sharp attacks of toothache, worse in the right upper teeth, coming on at intervals, at night (thirty-fourth day), 128.
Severe pains in the teeth, as if the nerves were suddenly pulled out, at night (thirty-fourth day), 128.
Sharp pains in nerves of teeth, in the evening (thirty-eighth day), 128.
Sharp pains in the nerves of the teeth (forty-fourth night), 128.
Drawing toothache in left upper teeth (fiftieth day), 128.
Violent shooting pains in upper teeth (thirty-fifth day), 128. [310.]
Sharp pains in the back teeth and jaws (fourth day), 128.
Sharp pains in the back teeth and in the articulation of the jaws (fifteenth day), 128.
Pains in the back teeth and articulation of jaws (nineteenth day), 128.
Tongue.
Tongue, gums, and lips violet, 12.
Tongue dry and papillæ erect, 49.
Tongue dry with white moisture on the edges, 26.
Tongue much coated, bad taste (seventh day), 178.
Tongue coated, bad taste (twenty-ninth day), 128.
Tongue felt hot (after thirty minutes), 123.
Soreness of the tongue and roof of the mouth (thirteenth day), 128.
General Mouth. [320.]
Mouth distorted, .

THROAT

Choking sensation in the throat, 71.
Dreadful sensation of choking, 57.
Choking sensation, as if something were tied round the throat tightly (seventeenth day), 128.
Most uncomfortable sensation about the throat and head and slight spasms of the muscles, 38.
Sensation of spasm in the throat and stomach, associated with ineffectual efforts to vomit, 72.
Stiffness about throat, 145.
Constriction of the throat and tightness of the chest, with rigidity of the muscles on attempting to move (after five minutes), 34.
There seemed to be some constriction about the throat, as it was difficult for him to swallow, 34. [350.]
Constriction of the muscles of the throat and larynx, 80.
Contraction of throat (after five minutes), 33.
A feeling of contraction in the throat, left side, shortly after rising in the morning (sixth day), 128.
Spasmodic feeling of contraction in the throat (eighteenth day), 128.
Contraction of the throat, with intense difficulty of swallowing (twenty-seventh day), 128.
Suddenly a sense of contraction in the throat; a feeling as if something were constantly rising in the throat, with sickness, in the afternoon (forty-eighth day), 128.
Feeling as of a lump in the throat, in the evening (thirty-sixth day), 128.
Painful dryness and contracted feeling in the throat (eleventh day), 128.
Painful dryness of the throat (twelfth day), 128.
Dry contracted feeling in the throat (fifteenth day), 128. [360.]
Dry contracted feeling in the throat, in the morning (forty-ninth day), 128.
Hot pains and dry sensation in the throat, coming on at intervals and lasting a short time (second day), 128.
Dry hot feeling in the throat (third day), 128.
On rising in the morning, a slight sensation of a sore throat, left side, with a general dry heat in the throat (fourth day), 128.
Soreness in the left half of the throat (seventh day), 128.

STOMACH

Appetite and Thirst.
Unusually good appetite, she enjoys her food amazingly (third day), 128.
Feverish thirst (sixteenth day), 128.
She asked for drink, 57.
Great thirst, 49.
Intense thirst, dry mouth and tongue, 43.
Eructations.
Eructations of bitter wind before vomiting, 43.
Eructations of tasteless wind, 43.
Bitter greasy risings, with bad taste (fourteenth day), 128.
Nausea and Vomiting.
Nausea, 43 ; (sixteenth day), 128. [390.]
At times felt great nausea (ninth day), 128.
Nausea and bad taste (twenty-first night), 128.
Nausea and bad taste, in the forenoon (twenty-seventh day), 128.
Nausea, with a feeling of pressure in the back of the brain, at noon (thirty-fifth day), 128.
Tendency to nausea, actual vomiting being only kept off by constant spitting (forty-fifth day), 127.
Nausea and vomiting (after first powder), 129.
Almost constant retching, 87.
Frequent effort to vomit, 73.
Vomiting, 62, 110, 121, 126.
Violent vomiting, 5. [400.]
Immediately became violently ill and cried and screamed in a most alarming manner, 143.
At times vomiting of thin colorless liquid, 23.
The chamber vessel contained about a pint of coffee-colored fluid, mixed with a more solid brown material, the whole supposed from its odor to have been vomited, and to contain most of the Strychnia (having drank coffee at supper), 113.
Vomited small quantities of some alcoholic fluid, 132.
Stomach.

ABDOMEN

Hypochondria.
Peculiar aching sensation in the right hypochondrium, at intervals, with sick, faint feeling (forty-third day), 128.
Tense pain in right hypochondrium (first night), 127.
Sharp cutting pains in left hypochondrium (twelfth day), 128. [430.]
Sharp pains right hypochondrium (twenty-seventh day), 128.
Keen, needlelike pains in the right hypochondrium, at the pit of the stomach, and also at intervals in the right knee-joint (thirtieth day), 128.
Sharp pains in left hypochondrium, at times, shooting to the pit of stomach, in the morning (nineteenth day), 128.
Rapid pulsation in left hypochondrium and left temple, in the morning (fortieth day), 128.
General Abdomen.
Abdominal muscles and those of neck and back in a state of tetanic spasm, 145.
Bowels much distended, 143.
Distressing flatulence, (twenty-ninth, thirty-sixth, and forty-eighth days), 128.
Distressing flatulence with sick feeling, at night (thirty-fourth day), 128.
Rumbling in the bowels, with a feeling of diarrhœa; also deep pains in the abdomen generally, at 7 P.M. (eleventh day), 128. [440.]
Rumbling in the bowels, with feeling of threatening diarrhœa, in the forenoon (eighteenth day), 128.
Sore, contracted feeling in the muscles of the abdomen generally (after one hour and three-quarters), 128.
Sore, contracted feeling in the muscles of the abdomen, especially the upper half (twenty-seventh day), 128.
Sore, bruised sensation in the muscles of the abdomen (twenty-eighth day), 128.
Painful soreness of muscles of upper half of abdomen, with sick feeling (thirty-seventh day), 128.
Painful soreness of the muscles of the abdomen, upper half, and at the pit of the stomach (forty-third day), 128.
Deep, sore pains in the muscles of upper half of abdomen (forty-first day), 128.
Severe, sharp pains in the muscles of the abdomen (fifth day), 128.

RECTUM AND ANUS

Gurgling sounds in the rectum, with sudden darting pains of greater or less severity. Some few days afterwards the symptoms in the rectum became much more marked; there was a constant gurgling sound, as if a considerable amount of fluid was there, in closed in a loose sac; the spasms of darting pain became more frequent, and were sometimes so unbearable as to force him down on the ground as if shot, 127 . [Sulphur 30 in globules, taken dry on the tongue three times a day, brought about rapid and almost complete relief of all the rectal symptoms.]
During the night, two most agonizing darts of pain in the rectum (forty-fifth day), 127. [490.]
Before going to bed, two darts of pain in the rectum, resembling shocks from a strong galvanic battery (forty-seventh day); excruciating pains in the rectum, of the same character as before (forty-eighth day), 127.
Slight twinges of pain in the rectum (fiftieth and fifty-first days), 127.
Spasmodic jumping in the anus, at night (fifth day), 128.

STOOL

Diarrhœa.
Copious watery diarrhœa, 89.
Purged copiously during the night, 50.
Sharp attack of diarrhœa (twenty-seventh day), 128.
Fæces discharged involuntarily during the spasms, 49.
The dejections lumpy and dry, the flatus having a smell as of fresh putty; dejections afterwards lumpy and accompanied by mucus, 127.
Constipation.
Very obstinate constipation, 33.
Constipation and griping pains in the bowels (fourth day), 128. [500.]
Large doses of cathartics were at first necessary to procure a movement of the bowels, and the black draught seemed to do better than any other form of cathartic, 161.

URINARY ORGANS

Bladder and Urethra.
The bladder seemed to participate in the general contraction of the voluntary muscles, and expelled small quantities of urine as fast apparently as it flowed into the viscus, 44.
After about ten days, perfect paralysis of the coats of the urinary bladder came on, and the regular use of the catheter was necessary for about two weeks, when the normal function of the bladder was gradually restored, 161.
Painful pressure in the bladder and rectum, 103.
Uneasiness about the bladder and urethra, at first slight, but daily increasing, aggravated by walking or sitting on anything hard (thirty-first to fortieth day), 127.
Occasional darting pains from the bladder down the thighs (thirty-first to fortieth day), 127.
Shooting pains about the neck of the bladder and down the rectum forty-fourth day), 127.
Shooting pains down the front wall of the bladder, and thence along the urethra (forty-first day), 127.
Unable to leave the house on account of the burning pain caused in the urethra by walking (forty-first day), 127.
On the forty-fourth day the pains left the bladder and settled in the glans, where they became constant and very severe, 127. [510.]
Renewal of scalding pain in the urethra (forty-seventh day), 127.
Occasional scalding pains in the urethra (fiftieth and fifty-first days), 127.
Micturition and Urine.
Constant urging to make water, the urgency not being removed by the act (thirty-first to forty-first day), 127.
No rest at night, being continually obliged to rise and attempt to make water (thirty-first to fortieth day), 127.
Very copious secretion of urine, 3.
Passes some urine under her, 132.
Urine scanty, with constant urging (twenty-fifth day), 128.
Urine very variable in character, sometimes natural in appearance, sometimes as dark as bad table-beer, sometimes with a thick red sediment, and sometimes with albuminous-looking masses floating in it (forty-fourth day), 127.

SEXUAL ORGANS

Male.
Left spermatic cord painful and the testicle swelled (forty-fifth day); testicle still swelled and painful (forty-sixth and forty-ninth days); testicle remains as before, swelled, but causing no pain, except in standing up or walking about (fifty-second day), 127.
The testicle continued in the same state, hard and swollen; eventually there came on burning pain in the left side of the scrotum, where the skin was tense over the testicle, and a large abscess formed in the dartos and cellular tissue. This was opened by a small incision, and yielded a very large quantity of semitransparent fluid, partly mixed with blood, after the discharge of which the size of the testicle became somewhat less; there was apparently no connection between the testicle and abscess, 127.
Female. [520.]
While falling asleep, quite suddenly several hysterical jerks as from the womb, with burning, irritating heat and violent pulsation in the passages; also a feeling of great pressure and bearing down (twenty-seventh night), 128.
Darting pain and thrilling sensation in the vagina, with momentary pulsation coming on at short intervals (thirty-first day), 128.
Violent tearing pains in the womb, coming on at intervals and lasting a few minutes (thirty-sixth day), 128.
The menstrual period came on the fifth day and lasted for the usual time, quite unaffected apparently by the proving. The menses came on again at the proper time, but lasted only two days, and were very scanty, 128.

RESPIRATORY ORGANS

Spasm of the muscles about the larynx and those of one arm; she felt and looked as if strangled; the muscles on each side of the larynx became tense like chords, 20.
Spasm of the respiratory muscles, so that breathing was irregular, intermittent, and difficult, 4.
Voice.
He spoke in a very low voice, which was somewhat indistinct, not only from his weakness, but from the frequent interruptions his utterance was subjected to from the violent jerks his whole frame suffered from tetanic spasms, 69.
Hoarseness, with a feeling as of a cold on the chest, lasting about two hours, in the morning (thirty-eighth day), 128.
Complete aphonia (soon), 104.
Cough.
Occasionally spasmodic explosive cough (seventh day), 127. [530.]
Dry spasmodic cough (forty-eighth day), 128.
Respiration.
Accelerated respiration, 12, 122.
Respiration quick and difficult, and attended with great pain in the præcordial region, 89.
Respiration rapid, with hard, rapid pulse, 26.
Breathing rapid and difficult, but larynx quite free (after twenty minutes), 30.
Breathing hurried, catching, and difficult, 63.
Respirations 35 per minute during the spasm, 136.
Inspiration deep, 71.
Short breathing with dry cough (fifty-fourth night), 128.
Respiration short and labored, 88. [540.]
Short breathing with dry cough (thirty-fifth day), 128.
Deep respiration, without convulsions, with loss of consciousness, followed by death, 26.
Respiration became irregular, intermittent, and short, 196.
Respiration sobbing and difficult, 122.
Choking character of breathing (after fifteen minutes), 107.
Difficult and interrupted breathing, ; (soon), .

CHEST

Walls of chest fixed, 130.
Spasmodic contraction of the muscles of the chest, about four times in a minute, with a feeling of impending suffocation (after twelve hours), 126.
Considerable oppression of the chest; constriction when taking a long breath (after twelve hours), 43.
Oppression in chest after meals, with flatulence (fifty-fourth day), 128.
Tightness about the chest, 33, 42, 49.
Soreness of the muscles of the chest and shoulders (twenty-second day), 128.
Sharp contractive pains in the muscles of the chest (first day), 128. [570.]
Severe, sharp pains in the muscles of the chest and in the shoulder-joints, at 7 P.M. (third day), 128.
Sharp pains in the upper part of the chest, right side, and in the top of the shoulders, coming on a short intervals (fourth day), 128.
Deep spasmodic pains in the chest and back, at 2 P.M. (eighth day), 128.
Sharp, deep pain in upper part of chest (twelfth day), 128.
Sharp darting pain in the lower part of the chest, in the evening (twenty-second day), 128.
Sharp darting pains in upper chest (twenty-seventh day), 128.
Spasmodic pains in the muscles of the chest and back part of shoulders (thirty-third day), 128.
Violent pains in the muscles of chest and neck (forty-third day), 128.
Gnawing and darting pains in the muscles of the chest and abdomen, accompanied by a sick, faint feeling (fifty-third day), 128.
Shooting pains in the muscles of the chest, left side, and under the jaws (second day), 128. [580.]
Sharp needlelike pains in upper chest and muscles of neck (thirty-fourth day), 128.
Sides.
Keen, sharp pains in the upper part of the chest, right side (eighteenth day), 128.
Keen, needlelike pains in right upper chest, in the forenoon (thirtieth day), 128.
Sharp pains in the left side under the ribs (thirty-fourth day), 128.
Severe, fixed pain in the upper part of the chest, left side (third day), .

HEART AND PULSE

Præcordium.
Tightness about the præcordia, 63.
During the day, dull pain shifting along the line of the aortic arch (fourth day), 127. [590.]
Fluttering sensation about the heart, with faintness, in the morning (fifty-fifth day), 128.
Heart's Action.
The heart's action was distinctly felt by the hand applied to the præcordia, 64.
Sudden palpitation of the heart, lasting a short time (forty-fourth night), 128.
Palpitation of the heart (twenty-seventh night), 128.
Tumultuous action of the heart, 9.
Impulse of heart strong (after twenty minutes), 30.
Irregular action of the heart, 145.
Pulse.
Pulse 88 and regular, 79.
Pulse regular, about 90 (between the spasms), 66.
Pulse accelerated, 3, 4, 29. [600.]
Pulse weak and rapid, 25.
Pulse very rapid, small, 122.
Pulse very rapid and easily compressed, 6.
Pulse quick, 119.
Pulse rapid, small, 106.
Pulse more rapid than usual between the spasms, 57.
Pulse about 150, 64.
Pulse frequent (about 130), but soft, 63.
Pulse 130 per minute, 121.
Pulse 120, small, regular, and corded or tense, and strong (after three hours and three-quarters), 50. [610.]
Pulse varying from 120 to 140, 131.
Pulse 115 to the minute (after one hour), 124.
Pulse 110, very compressible, 24.
Pulse 110 (after one hour and three-quarters); 140 during the spasms, 136.
Pulse 96, rather small and very irregular (after one hour), .

NECK AND BACK

Neck.
Neck swollen, the jugular veins distended, 4. [630.]
Marked rigidity of cervical muscles (after one hour), 124.
When she tried to lift her head the neck felt very stiff, 107.
Peculiar contractions of the muscles of the neck, especially the sterno-cleido-mastoids (after a few minutes), 141.
Neck feels stiff, 43.
Painful stiffness in muscles of neck and chest, extending down the back to the waist (forty-sixth day), 128.
Stiffness of nape of neck, with darting pains in the head and neck, in the morning (thirty-sixth day), 128.
Stiff hard feeling of the muscles of the neck (fourth day), 128.
Momentary stiffness in left half of neck (twenty-sixth night), 126.
Hard rigidity of the muscles of the neck (thirty-fourth day), 126.
Stiff sensation in the muscles of the neck, extending down the back to the waist (thirty-fifth day), 126. [640.]
Sharp cramp pains in the muscles of the neck (tenth day), 128.
Violent pains in the muscles of the neck and down the spine, in the forenoon (twenty-second day), 126.
Darting pains in the muscles of neck and to of shoulders (thirty-fifth day), 128.
Keen knifelike pains in the muscles of neck, chest, and abdomen, with sick feeling (forty-first day), 128.
Sharp darting pains in the muscles of the neck, in the morning (forty-second day), 128.
Violent pains in the muscles of neck and chest (forty-third day), 128.
Sharp needlelike stitches in muscles of the neck and in upper chest (thirty-fourth day), 128.
Intense gnawing pain in the left half of the neck, at night (seventh day), 128.
Dull aching pains at the nape of the neck and up behind the ears (first day), 128.
Violent pain in the nape of the neck and down the spine, at intervals, and lasting several hours, in the forenoon (twenty-third day), 128. [650.]
Sharp pain in nape of neck and down the spine at intervals (twenty-fifth day), .

EXTREMITIES

Fingers and toes violet-colored, the former spasmodically doubled inward and the latter drawn backward, 12.
Extremities outstretched and rigid and at times affected by jerking movements, especially rotating muscles, 78.
The arms became spasmodically drawn over the chest, the forearms immovable at the elbows; the lower extremities became rigid, 106.
During the paroxysms, arms and legs extended and rigid, 145. [710.]
Muscles of legs and arms rigidly flexed, 141.
Stiffness of the limbs, 48, 97.
Hard rigidity of the muscles of arms, legs, face, and neck (twenty-seventh day), 128.
Intense stiffness of the muscles of the legs, shoulders, and upper part of the chest, especially the calf of left leg, with external tenderness (twenty-sixth day), 128.
Stiffness of extensors of thighs and muscles of back of neck and hand, causing inability to write (fifth day), 127.
Slight stiffness of toes and arms (fifty-third day), 128.
A peculiar kind of twitching over her limbs (after one hour), 40.
Violent jerking of all the limbs, 3.
Severe drawing up of the legs and arms (after half an hour), 46.
Twitching of the limbs in bed, and spasms as if the heart was being firmly grasped (seventeenth day), 127. [720.]
Convulsive throwing about of the extremities, especially violent motions of the arms and hands towards the face, so that they had to be tightly held, with perfect consciousness and without pain, 7.
Spasms of the extremities interrupted by painful shocks, 75.
Convulsions of both upper and lower extremities, 51.
After a few minutes he began to feel tingling in his hands and arms, followed by rigidity, and spasms soon set in, 155.
Violent shuddering in the limbs as in paroxysms of ague, only on every attempt to move them; repeated in a tertian type and always ending in perspiration, 2.
Extreme weariness of the limbs, 23.
Extreme prostration and weariness of the limbs, 6.
Cramps in hands, feet, and legs (after thirty minutes), .

SUPERIOR EXTREMITIES

In about a half hour washed his hands, and immediately felt a sense of numbness, extending from the thumb to the whole of the hand and wrist, and rapidly to the elbow and shoulder. After two hours I found considerable swelling of the joints of all the fingers, and also of the wrist, but all numbness had passed off. At the time he despatched the messenger the arm was "enormously swollen and so dead that he could bang it against the wall without feeling it." On the following day the arm had recovered its normal size and appearance, 90.
Arms rigid and extended (after twenty minutes), 30.
Arms stretched out, hands clenched, 131.
Twitching of the arms (after one hour and a half), 46.
Jerking and trembling of the arms (twenty-seventh day), 128. [750.]
He had but little control over his arms; as soon as he let go his grasp on the bedstead they would jerk violently, and continue thus until he laid hold of something solid and immovable, 139.
Stiffening and twisted sensation in the arms and hands (twenty-seventh day), 128.
Rheumatic pains in the hands and arms, coming on at intervals during the day (forty-fourth day), 128.
Spasmodic jumping of the muscles of the arms, passing off suddenly (sixth day), 128.
At night when falling asleep, a peculiar spasmodic jerking, at times in the left arm only, and afterwards in the right hand (third day), 128.
A peculiar sensation about the arms and neck, accompanied with slight twitching of the muscles (soon), 39.
Shoulder.
Soreness of the muscles of the shoulders and chest (twenty-second day), 126.
Rheumatic pains in the back, part of left shoulder, and in the muscles of the arms and legs (fifteenth day), 128.
Sharp rheumatic pains in the socket of right shoulder, in the evening (fortieth day), 128.
Severe sharp pains in the shoulder-joints and in the muscles of the chest, at 7 P.M. (third day), 128. [760.]
Sharp darting pains in shoulders and elbows (sixteenth day), 128.
Sharp momentary pain in top of left shoulder, shooting down to the breast (after one hour, seventeenth day), 126.
Sharp needlelike pains in socket of right shoulder (fifty-fifth day), .

INFERIOR EXTREMITIES

Painful convulsions of the lower extremities and nape of neck, with lightning-like pains in the lumbar region constantly shooting, 24.
Very rigid tonic contraction of all the muscles of the lower extremities, rendering them fixed in a straight, extended position; no flexion of the legs could be accomplished, either at ankle, knee, or hip, without making use of greater force than I thought justifiable; the jaws were also firmly set, and the patient could not open his mouth by any effort he was able to make; the muscles of the trunk, chest, and upper extremities were but slightly, if at all, affected (after seven hours), 181.
Lost use of his legs, 152.
Loss of power in the lower extremities, 126. [800.]
Weakness of the lower extremities, trembling and loss of power, without loss of consciousness, 11.
The gait is feeble and tottering, and a general tremor pervades the whole body on attempting to walk, 63.
Hip.
Rheumatic pain and stiffness in the hip-joints (twenty-third day), 128.
Thigh.
Stiffness in the extensor muscles of the thighs, as if they were made of wood (second day), 127.
Stiffening of the muscles of the legs, especially the forepart of the thigh (twenty-seventh day), 128.
Rheumatic pains in the muscles of the thighs, at noon (nineteenth day), 128.
Severe aching in right upper leg (fifty-fourth day), 128.
Sharp cutting pains in the muscles of the left thigh, and in both arms (fourth day), 128.
Sharp needlelike pains in the inner part of the thighs, in the afternoon (twenty-eighth day), 128.
Knee.
Slight trembling of the knees (third day), 127. [810.]
Shaking of the legs, especially the knees (seventeenth day), 128.
Extreme stiffness of the knee-joints (eleventh day), 128.
Stiffness of the knee-joints (twenty-second day), 128.
Stiffness of the knee-joints and calf of left leg, in the morning (twenty-fifth day), 128.
Sore stiffness in the knees and in the calf of right leg (nineteenth day), .

GENERALITIES

Spasmodic convulsive twitchings, 62 , etc.
Spasmodic twitching of all the muscles, and general tremors, 145.
Every muscle of the body in a state of incessant twitching, which was greatly aggravated by touch, 130.
Twitching of limbs (after two hours), followed by violent tetanic convulsions and opisthotonos; the spasms were provoked by the slightest attempt to move, the entrance of any person in the room, or the closing of a door, 140.
On raising the hand to take hold of a cup, the hand was drawn back suddenly, as if it had been burned, and there came on spasmodic twitchings of both arms; she was obliged to eat with her elbows resting upon the table, the muscles of the forearm being under control, but not those higher up (after second dose, seventeenth day), 127.
Extremely violent twitching, first in the limbs, and then in the whole left side, 3. [880.]
Violent twitching of the whole half of the body that was paralyzed, with attacks similar to apoplexy, 3.
Twitching and paroxysms of tetanic spasm, 1.
Universal muscular twitchings, 30.
Violent starting up and shuddering of the whole body, 4.
During the intervals of his periodic convulsions, sudden and powerful shocks and twitchings occurred; these were produced or increased by the slightest touch. The twitching of the muscles of the face resembled those of epilepsy, 86.
Violent electriclike starting and shuddering in the whole body, followed by opisthotonos, with excessive rigidity, 126.
Shocks, stitches, and convulsive attacks in the paralyzed part, recurring at irregular intervals, always ending with sticky perspiration, 2.
Convulsive shocks passing through the body, with fixed feeling of the jaws and eyes, lasting for at least three hours (twenty-first day), 128.
Sharp convulsive shocks, with stiffening and trembling of the muscles generally, especially of the knees and jaws, at the second shock (twenty-fourth day), 128.
A single convulsive shock in left half of the body, felt first in the left foot and running quickly up to the head (thirty-fourth day), 128. [890.]
Violent convulsive shocks, with increased shaking and stiffening, and cold perspiration (forty-first day), 128.
Extremely violent shocks in the muscles, so that the right thigh was dislocated, .

SKIN

Objective.
Skin at first pale, became at last bluish, the face puffy and dark violet, the lips dark blue, the neck swollen, and the jugular veins distended, 108.
Skin livid, and complete redness of entire surface, 141.
The skin of the body became bluish, the capillary vessels filled with venous blood, 4.
Subjective.
Feeling of "burning all over" (after thirty minutes), 123.
Sensation of burning, itching, sticking, as of large pins in the skin, 33. [1130.]
Prickling in the extremities, 78.
Prickly sensation in the feet at intervals (forty-sixth day), 128.
In the place where the drug is rubbed in there are violent burning, sticking, and increased warmth, 29.
Formication of the extremities, 72.
Formication over the arms and lower extremities, 75.
Formication of the tips of the fingers, 5.
Intense itching of the skin of the entire body, even of the scalp (fourteenth day), 128.
Troublesome itching of the skin for about two hours (sixteenth day), 127.
Itching of the skin generally, more particularly of the legs and arms (thirty-fourth night), 128.
Intense itching of the skin (thirty-seventh, forty-first, and fifty-second days), 128. [1140.]
Intense itching of the skin, at night (forty-third day), 128.
Intense itching of the entire skin, lasting for several hours (fifty-third day), 128.
Intense itching of face, ears, and neck, at night (forty-fifth day), 128.
Intense itching of face, arms, and legs (fiftieth day), 128.
Itching of face, arms, and legs (forty-seventh day), 128.
Violent itching of the legs (twenty-first and twenty-fourth nights), 128.

SLEEP

Sleepiness.
Yawning and extreme weariness, in the afternoon (twenty-third day), 128.
Extreme drowsiness and chilliness (second day), 128.
General drowsiness, lasting for some hours (third day), 127.
Sudden drowsy sensation, at 11.30 A.M. (sixth day), 128. [1150.]
Extreme drowsiness, with stupid headache (fifteenth day), 128.
Drowsiness and loss of memory, with extreme giddiness (seventeenth day), 128.
Drowsiness and extreme dulness (twenty-fifth day), 128.
Drowsiness, with a shattered sensation in the head (thirty-third day), 128.
Extreme drowsiness and yawning (thirty-fourth day), 128.
Extreme drowsiness (thirty-fifth and forty-sixth days), 128.
Sleeplessness.
Sleeplessness, with internal uneasiness, anxiety, and oppression, so that she was unable to sleep, 24.
Sleeplessness caused by dread of the rectal spasms, 127.
Sleeplessness, visions of dead persons (first day).
Very sleepless night (twenty-seventh day), 125. [1160.]
Sleepless night (first and second night), 127.
Has not slept at all during the night, 43.
Not at all drowsy, rather the opposite, 43.
Extreme restlessness and talking in her sleep, accompanied by a peculiar working in the back of the brain (twentieth night), 128.
Restless nights, with profuse perspiration, since the last dose, the twenty-fourth day (twenty-seventh day), 128.
Restless nights and profuse perspiration since taking the last dose, on the thirty-first day (thirty-fourth day), 128.
Very restless night (forty-fifth day), 128.
Rest bad (forty-seventh day), 127.
Great restlessness (fifty-fourth night), 128.
At night, disagreeable dreams; strange wanderings of the imagination (sixth day), 128.

FEVER

Chilliness. [1170.]
Extreme chilliness (several days), 128.
Extreme chilliness and drowsiness (second day), 128.
Peculiar creeping chilliness all over, with a tremulous sensation in the jaws (third day), 128.
Extreme chilliness, even in a warm room (fourth day), 128.
Extreme chilliness and drowsiness (twenty-fifth day), 128.
Slight shivering (twenty-second day), 127.
Shivering, 6, 23.
Shaking chill, 75.
Icy coldness all over, with shivering and yawning (eleventh day), 128.
General coldness, especially in the sacral region, which feels as if iced (twenty-third day), 127. [1180.]
Icy coldness of the entire body (twenty-eighth day), 128.
A feeling of coldness suddenly came over him; he shivered all over, and his limbs became quite rigid, 142.
Whole surface of body quite cold, 139.
Surface cold, 47, 69.
Skin rather cool (after one hour and a half), 45.
Skin cold and clammy and of a dark livid hue, 147.
Painful coldness of the head, at 3.30 P.M. (seventh day), 128.
Peculiar creeping chilliness, with heat, in the right side of the head and face (first day), 128.
Cold chills passing over the head and down the back (forty-third day), 128.
Icy coldness of the head and down the spine (sixteenth day), 127. [1190.]
A single cold chill down the entire length of the spine; afterwards she felt deathly cold (third day), 128.
Icy coldness down the spine, accompanied by a kind of nervous shuddering (fourteenth day), 128.
Icy coldness down the spine (fifteenth day), 128.
Cold chills down the spine, at night (twenty-fifth day), 128.
Cold chills down the back, frequently (twenty-first night), 128.

CONDITIONS

Aggravation.
( Morning ), Headache; griping pain in bowels; weariness.
( Evening ), Thumping pain in head.
( Night ), Toothache; symptoms.
( Bending head down ), Stiff sensation up the spine.
( Exertion ), Pain in back.
( After meals ), Oppression of chest.
( Noise ), Tetanic spasms.
( Opening mouth ), Jerking sensation in stomach; jerks in back.
( Sitting on hard seat ), Uneasiness about bladder and urethra.
( After sitting ), Stiffness of muscles of legs.
( After standing ), Aching and stiffness in back.
( Touch ), Twitching of muscles; spasms; violent convulsions.
( Walking ), Uneasiness about bladder and urethra; burning in urethra; aching and stiffness in back; aching in shin bones; aching in feet.

SUPPLEMENT: STRYCHNINUM. Authorities.

162 , R. Gilsan, Amer. Journ. of Med. Sci., New Ser., No. 150, 1878, p. 449, a man, æt. twenty-five years, took a dose; 163 , V. R. Bridges, M.D., Chicago Med. Journ. and Exam., 1879, p. 48, a girl, æt. nine years, took an unknown quantity.

I found him in terrible tetanic convulsions. His legs and arms were extended, hands clenched, feet and toes incurvated, and his body was rigidly arched backward, and resting on his heels and back of his head. In short, all his muscles seemed to be in a state of rigidity. There were also the risus sardonicus , and a general cyanosed appearance of the skin. During the paroxysm the pulse was too frequent to be counted, and his pupils were slightly dilated. It was impossible on account of trismus and the violence of the general spasms, to administer an emetic by the mouth or to use the stomach-pump. The next morning I found him well, but still feeling some muscular soreness and fatigue, and fully resolved to let Strychnia alone in the future. He said no one could imagine the fearful agony it had caused him, and that he would rather be burnt to death than again suffer the pangs that he had endured from this horrible poison. He told me also that after taking the Strychnia he locked the door of his room, and lay down on his bed to die, as he supposed, in a rapid and easy manner. When the spasms commenced they soon put him in such fearful agony that he screamed for help, 162.
Continuous and persistent spasm from head to foot, with an alarming and distressing opisthotonos, rendered all the more painful from the fact that she was entirely unconscious of her sufferings, while any effort to relieve her by the slightest touch, or causing her to swallow, only aggravated her condition, by apparently exciting every muscle to increase its tension, 163.

STRYCHNINUM.