Myrica cerifera, L.

Natural order , Myricaceæ.

Common names , Bayberry, Wax-myrtle.

Preparation , Tincture of the bark of the root.

Authorities. (Nos.

1 to 7 , provings of the Mass. Hom. Med. Soc., 1864, Transactions, 2, p. 397).

1 , Dr. H. L. Chase, took 5 drops of extract; 2 , Dr. Chs. Cullis, took 10 drops; 2 a , same, second proving; 3 , same, Miss E., aged thirty, took repeated doses of 10 drops, each (9 P.M. first day, 7 A.M. second day, 7 and 11 A.M., third day); 4 , same, Mrs. H., aged thirty-one, took 10 drops, first and second days, and four days later 11 drops at 11 A.M., and 10 drops at 7 P.M.; 5 , Dr. Conrad Wesselhœft, dissolved 10 grains of extract in 1 ounce of alcohol, took 5 drops, first and second days; 5 a , same, took 10 drops of tincture at 11 A.M. and 10 P.M. first day, 15 drops at 7 A.M., and 25 drops at 10 P.M., second day; 6 , Dr. F. H. Krebs, took 5 drops of tincture at 11 A.M. and 4 P.M. first day, 5 drops at noon second day; 6 a , same, repeated three months later; 7 , Dr. J. E. Linnell. took repeated daily doses of tincture, 5 to 120 drops, for then days; [Subject to occasional rheumatic and neuralgic pains, and at this time suffering from influenza.]

8 , Dr. L. Walker, Hale's New Remedies, 2d. ed., p. 728, from Inaug. Thesis, 1865-6, took 1st dec. dil., repeated doses, 10 to 60 drops for three days, then tincture repeated, doses 20 to 140 drops for four days; 8 a , same, took powdered bark, repeated doses of 5 to 160 grains, for eight days; 9 , Dr. Wm. Sharp, M. Hom. Rev., 20, p. 749, proving of 1st dil., by a friend, and of 1 drop of tincture, night and morning, for eight days, by self.

MIND

Emotional.
A pleasant exhilaration (half an hour after second dose); followed by an excited state of the nervous system, precluding sleep for several hours; this was accompanied by a restlessness which required a frequent change of position (eighth day), 7.
A pleasant exhilaration, succeeded by depression and pressure about the head (ninth day), 7.
Depression of spirits (one hour after first dose, third day), 7 ; lasting three or four days (second morning), 2a.
Great depression of mind, irritable, do not want to speak or be spoken to, 1.
Great and unusual depression of spirits, all the morning (second day), 2.
Miserable dejected feeling all day (tenth day); (fourteenth day), 8a.
Great despondency , at 11 A.M. (second day), 2a.
Feels gloomy, terribly depressed ; this depression of spirits continued for three days, and to such an extent that it was impossible to write; did not care about anything or for any friends; was perfectly wretched, beyond description, 2.
Awoke in a gloomy state of mind, an unusual condition for him; felt very irritable, and had a constant desire to find fault; everything went wrong; looked upon this world as a place not fit to live in any longer; considered himself better than the rest, in the morning; felt very low-spirited; condemned himself for various imaginary faults; complete hypochondria, in the afternoon (second day), 6. [10.]
Felt irritable, easily provoked (after half an hour, fourth and fifth days), 7.
Irritable, worried by little things; everything seemed to go wrong, in the morning (tenth day), 7.
Exceedingly irritable; the slightest thing fretted and irritated him; ungovernable petulancy (sixth day), 7.
Intellectual.
Loss of energy (sixth day), 7.
Deficient concentration of the mind on any subject (after five hours and a half, seventh day), 8a.
Confusion of intellect; could not concentrate his thoughts (one hour after first dose, third day), 7.
Dulness of intellect (sixth day), 7.
Felt dull and drowsy, for the last two hours (five hours and twenty minutes after first dose, fifth day), .

HEAD

Vertigo.
Vertigo, with dulness and drowsiness much of the time during lectures, all the forenoon (tenth day), 8.
Slight vertigo (sixth day), 7.
Dizziness and rush of blood to the head and face, on stooping (premonitory symptoms of headache with him), (after two hours, second day), 5a.
General dizziness, all the morning, with feverish acceleration of the pulse, attaining its height about 4 o'clock (second day), 7.
Slight dizziness, with nausea (after first dose, second day), 7.
Slight dizziness, with repeated yawning, almost immediately (first day), 7.
Light-headedness and nausea (a few minutes after first dose, seventh and eighth days), 7.
General Head.
Dulness of the head (sixth morning), 7. [30.]
Dulness and heaviness of the head and eyes (fifteenth day), 8a.
Dull, drowsy sensation of the head, hardly to be called a pain on waking (eighth morning), 8a.
Heaviness of head (one hour after first dose, third day), 7.
Empty feeling in the head (soon), (second day), 5a.
Pain all through the head, quite severe in the temples, with throbbing in the superficial veins, attended with a semi stupor (after four hours, seventh day), 8.
Fulness about the head, with bad indescribable taste in the mouth (third morning), 7.
Awoke with dull pain in head and eyes (ninth days), 8a.
Dull pains in the head and back, on waking (fourth day), 8a.
Dull heavy pains all through the head, most severe in the frontis and through the temples, at 7 A.M. (seventh day), 8. [40.]
Head has ached all day, at 10 P.M. (second day), 2.
Slight headache (soon, and second morning), 2a ; on waking (seventh morning), 8a.
Awoke with severe headache, better after rising and washing with cold water (eleventh day), 8.
Head ached severely, particularly over the left eye, at 11 A.M. (second day), 2a.
Heavy headache followed the severe nausea (after five minutes, second day), .

EYE

Eyes congested and yellow (ninth day), 8a.
Dulness and heaviness of the eyes and head (fifteenth day), 8a.
Eyes feel dull and heavy, in the forenoon (eighth day), 8a.
Eyes feel heavy and dull (after sixteen hours and a half, seventh day), 8a.
Eyes feel heavy and weak, on waking (eighth morning), 8a.
Hot feeling in the eyes (after second dose, second day), 7.
Eyes burned and tired easily on reading (after nine hours, fourth day), 7.
Eyes feel swollen and with a yellowish tint, in the morning (tenth day), 8.
Awoke with dull pain in eyes and head (ninth day), 8a. [90.]
Sharp pain in left eye, at 9 A.M. (second day), 2a.
Left eye sore, and looked inflamed (third morning), 2a.
Both eyes quite sore, at 8 A.M. (second morning), 2a.
Smarting in eyes (after half an hour, fourth day), 7.
Smarting in the eyes followed evanescent itching, like fleabites (a few minutes after first dose, second day), 7.
Smarting, with dryness in both eyes, and feeling of sand in them, making it difficult to close the lids (after one hour, first day), 7.
Smarting in left eye (after five hours), 1.
Brow.
Dull, heavy feeling over the eyes, soon followed by a stricture across the nose (after fifteen minutes), 2.
Dull pain in right eyebrow (after half an hour, first day), 7.
Lids.
Eyelids heavy and swollen (second morning), 2a. [100.]
Fulness in eyelid of left eye, approaching to soreness (after a few minutes, second day), 3.
Quivering sensation in left upper lid (after half an hour, first day), 7.
Conjunctiva.
Conjunctiva congested and yellow (fifteenth day), 8a.
Smarting sensation in conjunctiva of left eye, followed by an aching pain in right eyeball (after half an hour, first day), .

EAR

Pain in back of left ear (after five minutes, first day), 3.
Ringing in the ears (sixth and seventh days), 7.
Ringing in the ears, with pressure about the head (tenth day), 7.
Ringing noise in left ear (after first dose, second day), 7.

NOSE

Objective.
Nasal organs affected very much like catarrh (ninth day), 8a.
An attack of coryza obliged him to omit the medicine (after two days), 6a. [110.]
A severe attack of coryza appeared towards night, and the miserable feelings in general prevented the taking of any more medicine (second day), 6.
Subjective.
Pressure in the nose (immediately after second dose, third day), 3.
Very severe pressing pain in left side of the nose, lasting about ten minutes, then shifting to left axilla, where it was sharp and lancinating (after four hours), 1.

FACE

Face and neck yellow (fifteenth day); complete jaundice aspect (seventeenth day), 8a.
Burning most of the day in the face, as one experiences in a cool day on coming into a warm room (first day), 7.
Burning about face and head, especially after being out in the open air (October 20th), (five hours after first dose, third day), 7.
Fulness about face and head, with throbbing (after second dose, second day), 7.
Feeling of pressure in both malar bones (after half an hour, first day), 7.
Sharp darting pain in articulation of jaw, right side, all day, 1.

MOUTH

Tongue.
Tongue furred (ninth day), 8a. [120.]
Thick, yellow coat upon tongue (fifth and sixth days), 7.
Tongue thickly coated, a dirty white or yellowish color (sixteenth day), 8a.
Mouth.
The whole buccal cavity, including the roof of the mouth, was coated with an adhesive coating, exceeding difficult to detach (eleven day); less in degree (twelfth day), 7.
Dryness of mouth and fauces (after half an hour, fourth day), 7.
Taste.
Sweetish taste about the palate, for half an hour (first day), 5.
Bad taste (sixth morning), 7 ; (ninth and sixteenth days), 8a.
Bad, indescribable taste in the mouth, with fulness about the head (third morning), 7.
Foul taste (eleventh day); less so (twelfth day), 7.
Bitter, nauseous sensation in fauces, with slight heat and burning in stomach (immediately), (second day), 5a.
Bitter, nauseous taste to the tincture (first day), 5a.

THROAT

Objective. [130.]
Stringy mucus in the throat, detached with difficulty (after sixteen hours and a half, seventh day), 8a.
Throat and nasal organs filled with an offensive, tenacious mucus, detached with difficulty (sixteenth day), 8a.
Subjective.
Dryness of throat (after first dose, second day), 7.
Constricted feeling in the throat; throat feels swollen inside, in the morning (fifth, sixth, and seventh days), 8a.
An aching, excruciating feeling in posterior nares, as if a fresh cold had been taken (after first dose, second day), 7.
Semi-lancinating pain in the right side of the throat, near the tonsil, in the afternoon (ninth day), 7.
Throat sore, sensation of a foreign substance requiring it to be frequently cleared; deglutition rather painful (fourth day), 8a.
Throat sore and rough, with frequent and difficult deglutition (after thirteen hours and a half, eighth day), 8a.
Slight soreness in the throat, on waking, and continuing through the day (third day), 8a.
Roughness of the throat (ninth day), 8a. [140.]
Roughness of the throat, requiring it to be constantly cleared (after fifteen hours, sixth day, 8a.
Throat rough and constricted (after seven hour, sixth day), 8a.
Dry, sore feeling in pharynx, as when one has taken cold succeeded by difficult deglutition (after half an hour, first day), 7.
Constant need to swallow, from sense of constriction in the throat (after five hours and a half, seventh day), 8a.

STOMACH

Appetite.
Increased appetite (five hours and twenty minutes after first dose, fifth day); constant hunger, yet a sensation of fulness, as if I had just eaten a hearty meal, although nothing has been taken into my stomach for five hours (ten hours and a half after first dose, fifth day); craving hunger; fulness of the stomach and abdomen (thirteen hours and three-quarters after first dose, sixth day); sensation of hunger and fulness in the stomach and abdomen, with rumbling of bowels, in the morning (sixth day); constant, craving appetite, with sensation of fulness in the stomach and abdomen (seventh day), 8.
Feel hungry; fulness in stomach and abdomen, on waking (fourth morning); craving hunger; fulness in the stomach and abdomen, as after a hearty meal, at 5 P.M. (before eating); continuing at 11 P.M. (fifth day); after eating (sixth day), 8a.
Appetite had been fair since commencing the proving, but not as keen as usual (fourth day), 7.
Appetite not so good as usual, but enjoyed a hearty meal, at 6 P.M. (after seven hours, first day), 5a.
Indifferent appetite (fifth day), 7.
Appetite poor, in the morning (seventh day), 8a. [150.]
Appetite for breakfast considerably impaired (third day), 7.
Appetite very much impaired (eleventh and twelfth days), 7.
No appetite (ninth day), 8a.
No appetite; took no breakfast this morning (fifteenth day), 8a.
No desire for food (tenth day), 8a.
No desire for food, but rather a loathing; strong desire for acids; ate very little breakfast, per force (sixteenth day), 8a.
Eructation.
Empty eructation (after second dose, second and third days), 7.
Frequent eructation of flatus from the stomach (after sixteen hours and a half, seventh day); in the forenoon (eighth day); relieving the pressure in the stomach for a short time only (fifteenth day), 8a.
Acidity of stomach, at 8.30 A.M. (second morning), 2a.
Heartburn, with an increase of saliva, which had to be frequently expectorated (after two hours, second day), 6.
Nausea. [160.]
Nausea (after half an hour, first day), ; (second morning), ; (third day), , etc.

ABDOMEN

Hypochondria.
Dull pain in the hepatic region (fifteenth day), 8a.
Umbilical.
Pain in umbilical region, immediately after breakfast (third day), 7.
Dull, heavy pain in umbilical region (after second dose, third day), 7.
Slight griping pain in region of umbilicus, with rumbling (after second dose, second day), 7.
General Abdomen.
Constant unusual rumbling in the abdomen, above the navel (three hours after first dose, first day), 5a.
Flatulency (after second dose, third day), 7.
Excessive flatulence, with frequent rumbling, as if diarrhœa would set in, urging to stool, with no other result than the expulsion of a great amount of flatus, in the afternoon (seventh and eighth days), 7. [190.]
Frequent passing of wind, very offensive (two small, sweet pears, eaten in the forenoon, may have caused the flatus; pears always do with him, but always odorless and painless ), (three hours after first dose, first day), 5a.
Constant passing of stinking flatus while walking (three hours after first dose, first day), 5a.
Weak, faintish feeling about the bowels, as when one has diarrhœa (tenth day), 7.
Felt, through the forenoon, as though diarrhœa would occur; weakness about the bowels, with urging and pressing, without stool (third day), 7.
Frequent sensation as of approaching diarrhœa, but without stool, in the afternoon and evening; only slight costive discharge in the evening (first day), 5a.
Occasional pains in the bowels during the afternoon and evening (eighth day), 8a.
Severe pain in bowels (half an hour after first dose, third day), 3.
Severe griping pains in the bowels during the night (first night), 2a.
Griping colicky pains continued at the intervals all the afternoon (first day), 5a.
Coliclike pain in umbilical region, in a small spot, with accumulation of flatus, one hour after dinner (three hours after first dose, first day), . [200.]

STOOL

Diarrhœa.
Bowels loose (eleventh day); two or three loose stools (twelfth day), 7.
Loose stool, accompanied with pain and tenesmus, after dinner (second day), 2.
Loose stool, accompanied with pain and tenesmus, at 6.30 A.M. (second day), 2a.
Soft, mushy stool, at 9 A.M. (ninth day), 8a.
Soft papescent stool, copious, attended with tenesmus and cramplike sensation in the umbilical region (after three hours, fourth day), 7.
Soft stool, with effort, in the morning (tenth day), 7.
Stool lighter-colored, at 9 A.M. (twelfth day), 8.
Loose, light-colored stool, at 6 A.M. (seventh day), 8a.
During the time my bowels have been rather more active than usual, and the color of the excreta much lighter, i. e.

of a lighter brighter yellow than usual, 9. [210.]

Stool natural, only too light-colored, at 8.30 A.M. (eleventh day), 6.
Stool nearly of natural consistency, but lighter-colored than usual, at 9 A.M. (tenth day), 8.
Stool rather light-colored, but of natural consistency, at 8.30 A.M. (fifth day); at 9 A.M. (sixth day), 8a.
Bowels torpid; soft, mushy stool, of a light clay-color (sixteenth day), 8a.
Constipation.
Constipation (sixth morning), 7.
Some constipation (third morning), 2a.
No stool (eighth day), 8a.
No stool for forty-eight hours, a very unusual occurrence (fourth morning), 7.
Stool about 11 A.M., being fifty hours since last stool (fourth hours after first dose, seventh day), 7.

URINARY ORGANS

Micturition.
Copious flow of limpid urine (tenth day), 7. [220.]
Difficulty in urinating; the bladder seemed to lack contractive expelling power (eighth night), 7.
Urine.
Increase of urine during the last three days (seventh day), 8.
Urine a light amber color and normal in quantity (before the proving); passed 31 ounces high-colored urine during the last twenty-four hours, sp. gr. 1020 (ninth day); 43 ounces during last twenty-four hours, color nearly normal (tenth day); 36 ounces, color nearly normal, sp. gr. 1013, a light-colored sediment after standing (the first that has been observed), (eleventh day); 37 ounces during the last twenty-four hours, sp. gr. 1028, considerable light-colored sediment after standing (twelfth day); 23 ounces, during last twenty-four hours, sp. gr. 1031, considerable light brownish colored sediment, after standing (thirteenth day); 47 ounces, during last twenty-four hours, sp. gr. 1024, no sediment discovered (fourteenth day); 24 ounces sp. gr. 1035 (fifteenth day); 22 ounces, during last twenty-four hours, sp. gr. 1029 (sixteenth day); passed 40 ounces during the last twenty-four hours, sp. gr. 1022 (seventeenth day); 33 ounces to-day, sp. gr. 1025 (eighteenth day); 33 ounces, sp. gr. 1021 (nineteenth day), 8.
Passed 27 ounces of amber-colored urine during the last twenty-five hours, sp. gr. 1028, at 11 P.M. (first day); 28 ounces, during last twenty-four hours, sp. gr. 1028 (second day); 24 ounces, a little darker than usual, sp. gr. 1030 (third day); 27 ounces, dark-colored urine, sp. gr. 1024 (fourth day); 30 ounces, rather darker than usual, sp. gr. 1023 (fifth day); 31 ounces, dark-colored, a pinkish-brown sediment at the bottom of the vessel after standing, sp. gr. 1024 (sixth day); 21 ounces, high colored, sp. gr. 1030 (seventh day); 20 ounces, high-colored, sp. gr. 1032 (eighth day); 19 ounces, very high-colored and frothy, containing considerable pinkish-brown sediment, sp. gr. 1031 (ninth day); 3 1/2 ounces, very high-colored, it looks like strong beer with a large amount of froth of a yellowish tint, sp. gr. 1032, in the morning (tenth day); very scanty, high-colored, and frothy, during the last four days (fifteenth day); 19 ounces, beer-colored and frothy, sp. gr. 1026 (sixteenth day); 15 ounces, very high-colored, sp. gr. 1031 (seventeenth day); 18 ounces, same general appearance as before, sp. gr. 1027 (eighteenth day), 8a.

SEXUAL ORGANS

Entire loss of sexual desire; a constant symptom through the proving (after three days), 8a.

RESPIRATORY ORGANS

Smarting in larynx and trachea (after one hour, first day), 7.
A tickling cough, which had troubled him on lying down at night, was entirely relieved (second morning), 2.
Offensive breath (eleventh day); less so (twelfth day), 7.

CHEST

When lying upon left side in bed, had a feeling of constriction in chest, with increase of the impulse of the heart, so that its pulsations were audible (first night), 7.
Pain in left lung, at 8 P.M. (second day), 2a. [230.]
Dull pain in right lung, middle lobe, lasting a few minutes (after half an hour, first day), 7.
A sharp pain once (lasting but a few minutes) in the chest, in the region of the heart (tenth day), 8.
Slight pain in left side (immediately after second dose, third day), 3.

HEART AND PULSE

Præcordium.
Stinging, cramplike sensation in the left portion of præcordial region, and under the ribs, immediately (after first dose, first day), 5a.
Heart's Action.
Increase of the impulse of the heart, so that its pulsations were audible, together with a feeling of constriction in chest, when lying upon left side in bed (first night), 7.
Impulse of heart's action increased, but number of pulsations diminished to 60 per minute (ordinary pulse, 75 to 80), (after second dose, second day), 7.
Pulse.
Pulse 76 and full, at 11 P.M. (third day); 63, small and feeble, on waking, normal (after six hours, fourth day); 80, one hour after eating, at 8.30 A.M.; 76, at 5 P.M., before eating; 71, at 11 P.M. (fifth day); 71 after eating (after seven hours); 72 (after fifteen hours, sixth day); 60, on waking; 70, before eating (after five hours and a half); 76 (after sixteen hours and a half, seventh day); 66, at 9 A.M., after eating; 67, before eating (after three hours and fifty minutes); 72 (after thirteen hours and a half, eighth day); 70, at 11 P.M. (ninth day), 8a.
Pulse 54, in the morning; 75 (before eating), (four hours and a half after first dose); 71, full and soft (five hours and ten minutes after third dose, second day); 51, feeble and irregular, in the morning; 65 (before eating), (three hours and a third after first dose); 59 (five hours and ten minutes after third dose, fourth day); 60, in the morning; 65 (one hour after eating, six hours and a half after first dose); 70, full and strong (ten hours and a half after first dose); 72, full and strong (fifteen hours and a half after first dose, fifth day); 56 and feeble, in the morning; 71 (one hour after first dose); 70 (thirteen hours and forty minutes after first dose, sixth day); 52, in the morning; 75 (after four hours); 66 (before eating), (after six hours); 62 (fifteen hours and a half, seventh day); 72, at 7.30 A.M.; 62, before eating; 70, at 11.30 P.M. (eighth day); 78, on waking in the morning; 76 (before eating), at 6 P.M.; 65, at 11 P.M. (ninth day); 71 (before eating), in the morning; 56 (before eating), in the afternoon; 61, at 11 P.M. (tenth day); 54 (before eating); 71 (after eating), in the morning; 61 (before eating), at 12.50; 68 (before eating), at 6.20; 60, at 11 P.M. (eleventh day); 59 (before eating), in morning; 82, at 4.30; 66, at 11 P.M. (twelfth day); normal (thirteenth day); 76 (half an hour after eating), in the morning; normal, at 10.50 P.M. (fourteenth day); 68, at 11.40 P.M. (fifteenth day), 8.

NECK AND BACK

Neck.
Pain and stiffness in the neck, especially in the nape, at 7 A.M. (seventh day), 8.
Pain in back of neck, at 2 P.M. (second day), 2a. [240.]
Dull pain in the muscles of the neck and in the frontis and through the temples, at 12.50 P.M., continuing through the day (eighth day), 8.
Back.
Pain in the back (seventh and eighth nights), 7 ; at 11 P.M. (ninth day), 8 ; (fifteenth day), 8a.
Pain in back, with lassitude (third morning), 7.
Dull pain in the back (after seven and fifteen hours, sixth day), 8a.
Awoke with dull pains in the back and head (fourth morning), 8a.
Dull aching pain in the back, in the forenoon (eighth day), 8.
Dragging pain in the back, in the evening (eighth day), 8a.
Dull dragging pains in the back, on waking (seventh morning), 8a.
Bruised pain in the back, and feeling as if a severe illness had seized him (fifth day), 7.
Dorsal.
Pain under the left scapula, at 11 P.M. (ninth day), 8. [250.]
Dull pain under both shoulder-blades (after three hours, second day), 3.
Lumbar.
Pain in back, in the lumbar region (one hour after second dose, second day), 7.
Slight aching pain in lumbar region, with general chilliness, when going out of doors (after first dose, second day), 7.
Dull aching pain in lumbar region (after five hours), 1.
Dull pain in the small of the back (tenth day), 8.
Awoke with dull pain in the small of the back and in the frontis and temples, same pain in back, in the afternoon (fifth and sixth days), 8a.
Dull heavy pain in the small of the back (ninth day), 8a.
Dull aching pain in the small of the back (after forty minutes, second day), 8a.
Dragging-aching pain in the small of the back, on waking, and continuing until afternoon (third morning), .

EXTREMITIES IN GENERAL

Dull pain in all the extremities, at 7 A.M. (seventh day), 8.
Aching pain in the upper and lower extremities (seven hours and a half after first dose, sixth day), 8.

SUPERIOR EXTREMITIES

Right arm felt lame and heavy, particularly about the wrist-joint (five hours after first dose, seventh and eighth days), 7.
Severe pain in left shoulder-blade and arm, extending to end of little finger (after half a hour, first day), 3.
Tearing pain in the left arm, principally between the shoulder and elbow-joints, and sometimes extending to the forearm, with a darting pain in the middle and ring fingers (after two hours and two days), 6.
Sharp and lancinating pain in left axilla (after four hours), 1.
Pain in the left arm, between shoulders and elbow, at 8.45 A.M. (second morning), 2a.
Pain in third and little finger of right hand, at 9 A.M. (second morning), 2a.

INFERIOR EXTREMITIES

Thigh. [270.]
Hard, drawing pain in the muscles above the knee (seventh night), 7.
Sharp, shooting pain in the right thigh, then in left thigh, followed by a dull pain in left shoulder (after one hour, first day), 3.
The pains about the limbs had all centred in the muscular part above the knees; a continual soreness existed, with occasional darting pains (twelve hours after first dose, seventh and eighth days), 7.
Knee.
Several times during the last two days have felt a sharp piercing pain at the inner side of the left knee-joint, but passing off so quickly I have not thought it worthy of much notice (sixth day), 8.
Leg.
Trembling and aching in the calves of the legs, so that walking is unpleasant (more pain in left), 1.
Pain from the knees down, with coldness of the lower extremities, at 12.50 P.M. (eleventh day), 8.
Severe pain midway between the knee and ankle, a little outside of the outer edges of the tibia; it was a contractive pain, with soreness to the touch, and worse on motion; it occasionally changed to a burning pain (one hour after first dose, seventh and eighth days), 7.
Soreness and pain in left tendo Achillis; worse upon pressure, and when in motion (after second dose, third day), 7.
Quivering sensation in the calf of the left leg, with a severe chill (after first dose, eighth day), 7.
Foot.
Pain in hollow of right foot (after three hours and a half, second day), 3. [280.]
Burning in the soles of the feet (first night), 7.
Bruised pain in the heel of the left foot (one hour after first dose, third day), 7.

GENERAL SYMPTOMS

Muscular lameness and soreness had become quite general, affecting chiefly, however, the lower limbs, in the afternoon (seventh and eighth days), 7.
No inclination to move, at 9 A.M. (second day), 2a.
General languor and depression of spirits (five hours after first dose, third day), 7.
Lassitude, with pain in back (third morning), 7.
A good deal of lassitude; weak, sick feeling; every kind of exertion was irksome, and required a special effort (after three hours, fourth and fifth days), 7.
Increased debility, can hardly keep around (eighteenth day), 8.
Feeling a little tired (after second dose, second day), 8.
Awoke feeling tired, as if I had been laboring hard (eighth morning), 8a. [290.]
General feeling of lassitude, with soreness of muscles of both thighs, as if he had taken cold, though there were no other indications of it (five hours after first dose, seventh and eight days), 7.
General malaise, and feeling of unfitness for duty (one hour after first dose, third day), 7.
Feel sick, debilitated all over (fifteenth day), 8a.
Constant miserable, sick feeling all over (seventeenth day), 8a.
Shifting pains (one hour after first dose, third day), 7.
Aching in the limbs and all over the body, like that preceding ague, at 10 P.M. (sixteenth day), 8a.
Some of the symptoms lasted for four weeks, 6.
Symptoms were increased by the warmth of the bed, disturbing the sleep (first night), 7.

SKIN

Objective.
Whole surface of the body presents a yellowish tint (sixteenth day), 8a.
Several pimples appeared in different parts, one quite painful on the nose (sixteenth day), 7.
Subjective. [300.]
Persistent itching in different parts, worst near the point of insertion of deltoid muscle in both arms (first day), 7.
Frequent itching and stinging sensations in right side of face, like the bite of a small insect, followed by similar sensations in neck, shoulder, forearm, and right leg, at a spot midway from knee to ankle (first day); the same evanescent itching, like fleabites, in a few minutes, followed by smarting of the eyes (after first dose); same itching in the different localities (ten minutes after second dose, second day); the itching of the face gave way to a creeping sensation, as of insects (after second dose, second day), 7.

SLEEP

Sleepiness.
Repeated yawning (after second dose, second day), 7.
Repeated yawning, with slight dizziness, almost immediately (first day), 7.
Drowsiness followed the sensation in the head, like foam rising in anything fomenting (after forty minutes, second day), 4.
Have had drowsiness, attended with vertigo, most of the time through the day, at 6 P.M. (ninth day), 8.
Drowsy and stupid, except when walking in the open air, in the evening (fifth day), 8.
Drowsy and dull, attended with vertigo much of the time during lectures, all the forenoon, but not much pain in head (tenth day), 8.
Drowsy while sitting in lecture-room, in the afternoon; felt better in the open air (twelfth day), 8.
Drowsiness, and soon fell sound asleep in my chair (forty minutes after first dose); sound asleep in my chair, and obliged to retire to bed (ten minutes after second dose, sixth day), 4. [310.]
Slept well all night (fourteenth night), 8 ; (second night), 5a.
Rested well through the night (first night), 3.
Slept very well all night (first night), 5a ; (seventh and tenth night), 8.
Slept quietly all night (eleventh night), 8.
Slept soundly through the night (ninth night), 8.
Slept sound, more so than usual, and until after 7 A.M. (an hour later than usual), (sixth morning), 8.
Sleeplessness.
Had a restless night (ninth night), 8a.
Restless night, slept but little (sixteenth night), 8a.
Passed a restless night, tossing about (first night), 2.
Had a restless night; considerable dreaming, but cannot recollect anything particularly about the subject dreamed of (sixth night), 8. [320.]
Had a restless night until 2 o'clock, then slept until 7 A.M. (eight night), 8a.
Restless towards morning (sixteenth night), 7.
Frequent waking; unable to sleep after 5 A.M., though he had a strong desire to do so (sixth night). .

FEVER

Chilliness. [330.]
Feel chilly when out in the air, at 10 P.M. (sixteenth day), 8a.
General chilliness when going out of doors, with slight aching pain in lumbar region (after first dose, second day), 7.
Severe chill, with a quivering sensation in the calf of the left leg (after first dose, eighth day), 7.
Feeling of coldness (after half an hour, first day), 3.
Cold chills running over the top of head, with tightening of scalp (ten minutes after first dose, sixth day), 4.
Coldness of the lower extremities, with pain from the knees down, at 12.50 P.M. (eleventh day), 8.
Heat.
Feeling of feverishness; yet the pulse was 60 (five hours after first dose, third day), 7.
Excited, feverish feeling, alternating with chilliness (one hours after second dose, second day), 7.
Sensation of warmth along the whole spine, especially between the shoulder-blades, followed by a slight chill and a gently perspiration, mostly perceptible over the dorsal vertebræ (after seven minutes), 6.
Face hot an flushed, at 8 A.M. (second morning), 2. [340.]
Face and head felt hot (after nine hours, fourth day), 7.

CONDITIONS

Aggravation.
( Morning ), irritability; on waking, headache; constriction in throat.
( Motion ), Pain in head; headache above eyes.
( Warmth of head ), The symptoms, 7.
Amelioration.
( Afternoon ), Pain in forehead, etc.
( Open air ), General feelings, 8 ; drowsiness, etc.
( After breakfast ), General feelings, 8.

Myrica