Antimon. Et Potass. Tart (Ant-t.) — Allen TF Materia Medica
Antimon. Et Potass. Tart
Tartar emetic, 2 [K(SbO)C4H4O6
By Timothy F. Allen — The Encyclopedia of Pure Materia Medica
] H2 O
Preparation , Triturations.
Authorities. [Symptoms in Stapf (Archive, 3, 2, 146), from Shæfer, Hufel. J., 1810, are omitted , being observed after tartar emetic given in canelle water; also Schœnfelder, do; observed from a solution of antimony glance (crudum) in acetic acid; also Goodwin, do., from tartar emetic mixed with camphor; also Barbier, see Hencke's compilation, A. H. Z., 88, 5, tartar emetic mixed with chicory; also Jankovich, do., from tartar emetic mixed with opium.]
1 , Hartlaub and Trinks, Reine Arznei-mittldehre, 2, 209; 2 , S. Hahnemann, Archive, 3, 2, 146; 3 , Rückert, do.; 4 , Gross, do.; 5 , Stapf, do.; 6 , Fr. H-n, do.; 7 , Hering, Archive, 13 z., 183; 8 , "M.", in Buchner's review, Hygea, 18, 274, took first dil. repeated doses; 9 , do. took one grain at once; 10 , Molin, Comptes rendus du Congrès Méd. Hom. d. Paris, 1851-56, proving with sixth and eighteenth dilutions, repeated doses; 11 , Nœbling, N. Z. f. H. K., 14, 80, proving with several small doses and subcutaneous injection; 12 , Bœcker Beitrage, crude proving; 13 , Mayerhofer, in Bœcker Beit., effects of one one-hundredth of grain; 14 , De Moore, Rev. de l. Mat. Med., 5, 436, proving with one-quarter grain; 15 , Macfarlan, Am. J. Hom. M. M., 4, 60, prov. 3m Fincke; 16 , Woodbury, N. E. Med. Gaz., 4, 238, four grains a day for fifteen days; 17 , Giaccomini, N. Archive, 1, 2, 107, one scruple; 18 , Hutchinson (in Stapf's collection, Archive, 3, 2, 146, effects of inunction), (see also Wibmer); 19 , Blackburne, do.; 20 , Horst, do., inunction (Hufeland's Journ., 1813); , Bonetus, do.; , Elias, do. (Hufel. J., 20), eight grains in a clyster; , White, do.; , Bæumlinus, do.; , Stutz, do. (inunction); , Autenrieth, do. (inunction); , Hecker, do. (inunction); , Walther, do. (four pounds in milk, the curds eaten by two students); , Serres, from Hencke's collection, A. H., Z., 88, 5 (and also from Wibmer); , Troschel, do.; , Driver, do.; , Male, do.; , Duffin, do.; , La Clinique, do.; , Med. Gaz., do.; , Wetzler, do.; , Krebs, Hygea, 20, 289; , Hildebrandt, do.; , Imbert-gourbeye, Brit. Journ., 19, 367, et seq ., eruption from inunction; , Bœckh Frank's Mag.; , Lembert, do.; , Crichton, do.; , Wesener, do.; , Schneider, do.; , Carron, from Wibmer; , Orfila, Toxicologie (from Roth Mat. med.); , Recamier, do.; , Constant, from Roth; , Savory, do.; , Sachi, do.; , Baumbach, do.; , Freer, Lancet, 1847 (effect of two drachms); , Harley, Lancet, 1846 (effect of ten grains on a child); , D. Kiger, O. M. and S. Rep., 5, 171 (child swallowed one-half ounce crude).
The anxiety increases with the nausea , together with a slight pressure and some warmth in the abdomen, which moves about with the free flatulence, 5.*
He rubs his eyes with his hands as if in a stupid sleep, and wakes in a very ill-humor, e. g. , if one looked at him he began to howl, 5.
The child will not allow itself touched, without whining and crying , whereby the toes and fingers are drawn inwards, 2.
The whole time an unusual, noticeable (more to others than to herself)
wild gayety, toward evening ; this gave place to fretfulness, peevishness, and anxious thoughts about the future; she thinks she will remain in her present condition, 3. [20.]
Head heavy, confused, with great discomfort on waking, mornings (ninth day), 8.
The head is heavy, confused, and painful, with internal heat in the head (3 P.M.); it becomes better in the open air, and does not return again in the room, 1.
Violent tearing between the root of the nose and the right eyebrow, as if some one took hold of her there by the skin; very painful and long-lasting (after half an hour), 1.
Flickering before the eyes, especially on rising from sitting, several times in an hour, of short duration; she sees only as through a thick veil , with vertigo (several days), 3.
Blackness before the eyes, , .
EARS. [150.]
Twitching-tearing in the right concha, in the evening on lying down, which disappears in bed, 1.
Ulcerative pain in the right concha, in the evening (after two days), 1.
Twitching, painful tearing in the right ear, in the morning (second day), 1.
Fluttering before the left ear, as from a large bird; at the same time a warmth passes to this ear, as if she stood near a hot stove; gradually disappearing (after one and a half hours), 1.
NOSE
The corners of the nostril are ulcerated and painful (fourth hour), 2.
The right and left sides of the upper lip are full of clear, itching vesicles, which, on drying up, are replaced by new ones; the itching is especially violent in the evening, 1.
On the right side of the lower lip several clear vesicles; at the same time the right side of the upper lip is swollen and covered with small pimples, with tensive pain on pressure, 1.
Burning externally on the right side of the chin, which lasts but a short time (after one hour and a half), 1.
Burning on the right side of the chin, as if one held a hot coal to it (after one hour and three-quarters), .
Tearing pain on the left side, behind the root of the tongue, noticed on swallowing, 5.
In the morning after rising, the mouth is so sore that she can scarcely swallow, with white tongue and sour taste (second day), 1.
An unpleasant sensation on the palate the whole time, 3.
On the posterior part of the palate, sensation of soreness, and as if a hard body lay against it; without swallowing; it disappears on eating bread (8 A.M.), 1.
Itching below the right corner of the mouth, where, after scratching, three vesicles arise; also under the left corner (second day), 1.
Though food tastes good and he has some appetite, yet he can only gradually get some food into his stomach, from which he feels better, and the pressure in the abdomen is somewhat relieved (first day), 3. [260.]
On eating, soon satiated, almost nauseated, must stop eating, 12.
He eats at noon with appetite, but after he is satisfied a kind of nausea attacks him at times, 4.*
Around, below the short ribs, sensitive painful tension, so that he can hardly sit, but would rather lie, from incarcerated flatulence, which passes off from time to time, 4.
Dulness over the liver, increased one finger's breadth at the base, 11. [390.]
Epigastric and liver region some what tense (fifth day), 8.
A very sensitive sticking pain in the lower part of the bladder; he believes that the pain must be caused by troubles from a stone (third day), 3.
Burning in the urethra while urinating (eighth day), 1.*
Violent burning in the urethra after urinating (third day), 3.*
Slight tearing pain in the forepart of the urethra, 5.
Continued sticking pain in the posterior portion of the urethra, the whole forenoon (second day), 3.
The urging to urinate and the burning in the urethra increase, only a little urine passes; the last drops are bloody and accompanied by violent pain in the bladder (fourth day), 3.* [510.]
A burning irritation, very singular, more like a tickling, though not at all voluptuous; rather very troublesome; not relieved by anything; extends from the region of the rectum, through the urethra, to the glans, where the tickling is most severe (lasts six to seven days without interruption, and is his most distressing symptom), 3.
Pain, as if bruised, in the upper part of the chest, on bending the head forward; on rising, it is relieved, but returns on stooping again (after two hours), 1.
An almost sore, paroxysmal feeling in the chest, especially in the left side, toward evening, the second day, with a hopeless, despairing mood, 3.
Rawness and constriction in chest, and expectoration of mucus, 12.
On stooping, a fine stitch on the right lowest rib (after one and a half hours), 1.
Pain in right side, behind and at base of chest, aggravated by deep breathing, 10.
An itching stitch on the right nipple (after three-quarters of an hour), 1.
Burning in the left breast, near the shoulder, more externally; on pressure or rubbing, it is worse; then it diminishes and intermits somewhat of itself (after half an hour), 1.
Long-lasting painful stitching in the upper left side of the chest, near the clavicle, and at the same time in the left axilla (after two hours), . [600.]
HEART AND PULSE
Pulsation of the heart small and irregular (fifth day), 8.
Pressive sense of fatigue in the cervical muscles, close to the occiput, especially on the right side, 5. [640.]
Does not like anything to touch him; inclination to unbutton the collar of his shirt, 10.
On turning the neck, over the left scapula, and also on taking hold of anything, painful aching, which comes suddenly, and then becomes continuous; twenty-four hours later, over the right scapula, 4.
A fine stitch between the shoulder-blades (after two hours), 1.
Pain in the back, as from fatigue, several days, especially after eating and while sitting, 3.
Short sticking-tearing pain, especially in the lower right side of the back, near the right hip, 5.
A pain in the small of the back, before and on rising from the bed, as if one had carried a weight there; after rising, it disappears.
Rheumatic pain in the lower part of the back, just above the sacrum, mornings, 5.
Sharp stitches in the region of the kidneys on moving the arm, 2.
Burning and tearing in the joints (sixth to seventh day), 8. [660.]
Drawing and tearing in the joints (eleventh day), 8.
Slight rheumatic drawings through the whole right hand, immediately afterward, drawing through both legs from above downward, especially in the region of the knee, and noticed on walking (two hours), 5.
Short, rheumatic pain, around and in the shoulder-joint, and the left breast, 5.
A violent tearing, externally in the right shoulder, followed by itching (after one hour), 1.
Violent itching in the left shoulder; after scratching, a number of small vesicles arise, and she must scratch till they bleed, without relief to be itching whereupon the spot burns; the vesicles dry after three days, 1.
Fine stitching and twinging below the left axilla; then a stitch, with twinging, on the condyles of the left elbow (after two hours), 1.
A twinging sensation in front of the left axilla, as if one raised the skin (after two hours), 1.
Severe jerking in the right arm, is not relieved by motion (immediately), 3.
Burning on the inner surface of the right upper arm, toward the shoulder, with yawning (after two hours), 1.
A drawing down along the outer surface of the left upper arm, almost as if in the bone, in several short paroxysms, 4.
A fine boring in the right humerus, as if in the marrow, which frequently increases, then extending into the shoulder, frequently somewhat diminished; it disappears on pressure, and is relieved on motion of the arm, but frequently returns (after one hour), 1. [680.]
Itching on the external surface of the right elbow, which disappears on scratching (after three-quarters of an hour), 1.
On the forearm near the wrist, an eruption of pimples like the itch, also on the upper arm; the itching is relieved by scratching, 2.
Transient, rather severe tearing in the muscles of the left forearm, 5.
A twinging or sensation as if something would raise the skin, on the inner surface of the left forearm; on pressure it disappears, but returns again (after half an hour), 1.
Violent itching on the external surface of the left forearm; on scratching, small pimples appear, which burn, and the skin becomes rose-red, but white on pressure; the redness continues two hours (6 P.M.), .
Just below the left hip, transient rheumatic pains, 5.
Spasmodic twitchings of the muscles of the thigh (eleventh day), 8.
Tension in the hamstrings on walking, evening, 2.*
Rheumatic drawing in the upper part of the right thigh, 5. [710.]
Twinging on the anterior surface of the left thigh, as if one pinched him, or raised his skin with a needle; the spot continued to pain still longer in the open air (after two hours), 1.
In the morning in bed, and on rising, aching in the bones of the knee-joint, as if the limb had no power, and as if the tendons were overstretched and strained, 2.
Tearing, a hand's breadth above and below the knee, on the external surface (after two hours), 1.
Evenings in bed, sticking in the knee and hip (first day), 3.
On the left side below the left knee, a slow, throbbing, sensitive picking, in rest and motion, 4.
Anxious restlessness and tossing about (fifth day), 8.
Great general discomfort, which starts from the abdomen; he groans and moans involuntarily; restlessness drives him from sitting to standing, and walking about, .
Eruption of bright red, small, conical, distinct, hard pimples, with an inflamed base like lichen simplex , thickly covered the breast, anterior surfaces of the upper arms, wrists, hypogastrium, and inner surfaces of the thighs, 16. [800.]
Vesicular eruption over the body (internal use), 42.
Pustules, when it is rubbed in, also on other parts of body, as nasal fossæ, margin of anus, glans penis, genitals, arms, etc., 39.
A thick eruption like pocks, often pustular, as large as a pea, filled with pus, 27.
Eruption of itching pustules, which soon dry up, 12.
From applying antimonial ointment to the dorsal region considerable local eruption was produced; in six days itching on scrotum; on ninth day five pustules on scrotum and three on penis, 39.
Eruption of pimples and vesicles, which in two days are filled with pus, are like the pustules of small-pox and are very painful; these pustules dry up and form crusts; this eruption appears first on the internal surface of the forearm, then on the back (from internal use), 40.
At first small, red pustules; the third day increased in number and size; the fourth day most of them had a brown everted margin, were covered by crusts similar to cow-pox, and contained much matter in the centre; the sixth and seventh days some were as large as the thumb-nail, shaped like a flat ulcer, and contained much thin matter, 20. [810.]
Most of the suppurating places became confluent the eighth day, and discharged blood and matter, 20.
The corners of the nostrils are ulcerated and painful (four hours), 2.
Exceptional sleepiness and overweening inclination to sleep, 18.
Forenoons, great desire to sleep; if he sits still he sleeps immediately, with vivid dreams of a continuation of his previous thoughts (second day), 3.
The eyes close involuntarily, forenoons; he falls asleep, and often starts up violently, but at once goes off again (first day), 3. [870.]
In the morning, at 10 o'clock, could not get out of bed from sleepiness, and was so heavy and inclined to sleep, and his limbs were so tired and gone-to-sleep that he could hardly stand, 28.
At 10 A.M., he still feels a disposition to sleep, which he is unable to shake off; he is so fatigued and prostrated that he can scarcely keep himself up, 42.
Such an irresistible inclination to sleep by day that when he went about and stood, fell asleep as soon as he sat down, 2.
Even when getting on horseback, in the strong air, he feels sleepy, and can hardly overcome his drowsiness, 42.
Could hardly keep awake, and was dizzy when riding in the open air, 28.
Evenings (quite contrary to custom), he is sleepy very early that he can hardly keep awake, and half an hour later he becomes wide awake and remains so till late at night, 4.
From morning till evening constantly chilly, as soon as she goes from the room into the open air, 1.
During normal stool cold shivers through the skin, 12.
Chill over whole body, with trembling and shaking at 3 P.M. (for several hours), 2.
He looks pale and suffering, and is so chilly on going into the open air that he trembles, 4.
Chilliness, as if cold water had been dashed over him, with gooseflesh on the arms, and repeated yawning (soon after taking it), 4. [930.]
In the morning after rising, for half an hour, chill, with gooseflesh, and likewise at 7 P.M., for two hours, after which thirst follows, at 9 o'clock (third day), 1.
Chilliness, with gooseflesh and cold skin over the whole body, which remained a long time on the hands (ninth day), 8.
Trembling and chilliness over whole body, always from within outward, without ability to get warm, with a general sick feeling (eighth day), 8.*
( Morning ), Head confused; on waking, head heavy, etc.; heat on forehead; heaviness in head, etc.; twitching-tearing in right ear; violent toothache tongue thick yellow; after rising, mouth sore, etc.; after waking, sour taste in mouth; on waking, sour taste at back of tongue; dryness in throat, etc.; loss of appetite; frequent eructations, etc.; early, colic around umbilicus; after rising, cutting in rectum, with stool; cough, etc.; pain in lower part of back; in bed and on rising, aching in knee-joint; on rising, chill; after rising, chill, etc.; on waking, profuse, general sweat.
( Forenoon ), Head heavy, etc.; sticking in urethra; frequent urination; stretching and yawning; eyes close involuntarily, etc.; severe chill.
( Afternoon ), Headache, etc.; coating on tongue thicker; on motion, surging toward neck upwards, etc.; on sitting crawling in abdomen; cramp in calves; constant heat.
( Toward evening ), Hopeless, etc., etc.; fretfulness, etc.; catarrhal symptoms; sore feeling in chest, etc.
( Evening ), Pain in side of forehead, etc.; heaviness in head, etc.; burning in eyes; on lying down, twitching-tearing in right concha; ulcerative pain in right concha; itching heat in upper lip; on going to sleep, whirling in pit of stomach, etc.; late, aching in pit of stomach; toward 9 o'clock, cutting in abdomen; two soft stools; frequent urinating; voice changed; in bed, suffocative feeling; on waking, tension in hamstrings; in bed, sticking in knee, etc.; on lying in bed, itching in the sore; in bed, itching biting in left sole; heat all over.
( Night ), On waking, bad headache etc.; on waking, cracked lips; violent nausea and vomiting; stomach feels loathed, etc.; whirling, etc., of the heart; chill screams, etc.; chill.
( Before midnight ), Cough; sleeplessness.
( Midnight ), Wakes with thirst, etc.
( Morning till evening ), Constantly chilly.
( Morning till 5 P.M .), Headache, etc.
( 11 A.M. till evening ), Stitches in head.
( 2 P.M. till 3 A.M .), Sticking in forehead.
( 2 to 3 A.M .), Cough, with expectoration.
( About 3 A.M .), Suffocated.
1 P.M .), Headache etc.; cramp, etc., in bowels; pain above pubis, etc.
(
3 P.M. ). Head heavy, etc.; nose-bleed; chills all over, etc.
(
4 P.M .), Feeling of heat in head.
( Toward 6 P.M .), Tension in abdomen.
(
6 P.M .), Febrile chill.
(
7 P.M .), Chill, etc.
( Towards 8 P.M .), Fever.
( Open air ), Twitching on left thigh; from warm room, constantly chilly; chilly.
( Motion in open air ), Tearing in left temple.
( Walking in open air ), Canine hunger; head, etc., feel swollen.
( Anger ), Cough.
( Bending head forward ), Pain in upper chest.
( Sitting bent ), Pressure in abdominal; pressure in abdomen, etc.
( Deep breathing ), Pain in right side.
( Closing eyes ), Vertigo.
( Coughing ), Heat, etc., of forehead; dull pain in forehead; vomiting of food; heat, etc., of hands, etc.
( After dinner ), Qualmishness in stomach; sensation as if overloaded in stomach, etc.; tearings in rectum; sleep.
( Drawing in the abdomen ), Sticking from below pit of stomach; small spot in abdomen hurts.
( After drinking ), nausea.
( After eating ), Nausea; nausea and vomiting; rumbling in abdomen; pain in abdomen; cough; pain in the back; violent heat, etc.
( Expiration ), Stitch in abdomen aches.
( Before each epileptic attack ), Burning in chest.
( Taking hold of anything ), Aching in neck.
( Trying to lift head from pillow ), Dizziness.
( Looking at object a long time ), Sight vanishes.
( After a meal ), Creeping, etc., in abdomen.
( Motion ), Heat in head; stitches in head; pressure in forehead; trembling of hands; chill, etc.
( Rapid and violent motion ), Pain.
( Moving arm ), Stitches in region of kidneys.
( Pressure ), Pain in pimples on upper arm; burning in left breast; stitching in fingers; pimples on buttock pain.
SUPPLEMENT: ANTIMON. ET POTASS. TART. Authorities.
55 , Dr. Mackintosh, Lancet, 1827-8 (2), 536, A. B. took 20 grains in a little sugar; 56 , Usher Parsons, Bost. Med. and Surg. Journ., vol. iii, 1830, three servants took over 40 grains each; 57 , Wm. F. Porter, M.D., Lancet, 1832 (1), p. 46, effects of a large quantity; 58 , George Lefevre, M.D., ibid., 1844 (1), p. 444, a lady swallowed 25 grains; 59 , J. T. Gleaves, M.D., West. Journ. of Med. and Surg., 1848, R. æt. twenty-four years, took a tablespoonful; 60 , John S. Beale, Lancet, 1854 (1), p. 68, a girl, æt. sixteen years, swallowed from 40 to 60 grains, death; 61 , C. Ellis, M.D., Bost. Med. and Surg. Journ., vol. lv., p. 400, fatal poisoning of Miss ---, æt. twenty-one years; 62 , John Gabb, Med. Times and Gaz., 1866 (2), p. 379, a man, æt. forty-three years, took 3 teaspoonfuls; 63 , Alfred Nobiling, Versuche uber die Wirkungen des Brechweinsteines in kleiner Dose bei längerena Fortgebrauche, München, 1868; 64 , Sharp's Essays on Medicine, 1874, p. 725, took Ant. tart. 1st, 1 drachm; 65 , John Morley, Brit. Med. Journ., 1876, p. 492, a lady, æt. eighteen years, took over a teaspoonful; 66 , F. Mason, ibid., 1877 (1), p. 674, a man swallowed 80 grains.
Pustular eruptions of the tongue and lining membrane of the mouth, of the character of those produced on the skin by the application of the ointment, 57.
Pulse 72 (before experiment); 70 (after two minutes); 72 (after five minutes); 67 (after ten minutes); 72 (after fifteen minutes); 71 (after twenty minutes); 74 (after twenty-five minutes); 68 (after thirty minutes); quickened by the deep breathing, 70 (after thirty-five minutes); 72 (after forty minutes); 77 (after fifty minutes); 66 (after one, and two hours), 64.
Rolling upon the ground in great agony, vomiting blood, and tormented by agonizing colic pains, 58.
In half an hour violent nausea was induced, but vomiting did not commence till 2 P.M. (after three hours), after which it became more violent till three, when it seemed at its height; a quantity of bile was at first ejected, afterwards painful strong retching, with an obtuse fixed pain at the epigastrium, which was not always referred to the same spot, and accompanied by great thirst; a slight discharge of mucus at intervals ensued. About 4 P.M., the above-mentioned symptoms gradually disappeared, and were succeeded by great and universal prostration; two very copious, bilious stools were passed. In the evening, after taking some tea, a profuse perspiration broke out, which appeared to be the last effect of the medicine, 55.
Unable to stand; scarcely able to speak; exhausting evacuations, both from the stomach and bowels; weak, contracted pulse; cold clammy sweat; extreme paleness; prostration of strength, 56.
In about two hours he felt an inclination to evacuate his bowels, and the alvine discharges continued involuntarily. Breathing slow and laborious; face pale and altered, features shrunken; eyes fixed and turned upward, pupils dilated; surface cold; appeared to be unconscious, but stated afterwards that he knew what was passing around him; the action of the heart was intermitting and extremely feeble, and no pulse could be felt at the wrist (in three hours); complained of great thirst, and a sense of burning in fauces, œsophagus, stomach, and lower bowels (in seven hours); throat sore; fauces covered with pustules, some of which, having discharged their matter, have left soft superficial ulcers (second day), 59. [980.]
Within a quarter of an hour after vomiting came on, very sharp; and a little while after smart purging. These symptoms continued for about three hours. She also complained of pain down the œsophagus, and described it as "burning her." She then fell asleep. The vomited matter was very dark. Delirious during the six or-eight hours previous to her death, .
SUPPLEMENT: ANTIMON. ET POTASS. TART. Authority.
67 , Dr. Molin, Des Spécifiques en Médecine, Paris, 1847 (Brit. Journ., vol. vi, 1858, p. 118).
Observation 1.
Being in a good state of health, my pulse beating 64 per minute, I took at 8 A.m., before breakfast, 5 milligrams of Tartar emetic in water. This dose was repeated for five days without perceptible effect. The sixth day I felt nothing until 4 P.M. The respiration then appeared to me a little less free. Feeling no further effects, and my appetite continuing good, I took on going to bed about 9 o'clock, a dose of 1 centigram. The night was passed in a restless manner, and the sleep interrupted by a fatiguing heat; I felt necessitated to drink several times; the respiration was slightly impeded; on rising, general uneasiness, weariness, similar to what follows a febrile fit, the mouth clammy. I took at 8 o'clock in the morning, 1 centigram. No appetite; a simple soup for breakfast without relish. All the day I was in the same state. About 5 P.M., greater uneasiness, especially about the epigastric region; nausea; desire to vomit, but without result; respiration more impeded; short dry cough, pretty frequent; great thirst; heat in the head; white tongue; drinks appear always too sweet; clammy mouth; two loose evacuations during the day; palpitation of the heart; bruised feeling and general weariness, compelling me to go to bed at 8 o'clock. The ear applied to the chest gave evidence of nothing abnormal, except that the respiration appeared much too rough. At 9 o'clock I took another dose of 5 milligrams. Agitated sleep, difficult respiration, feeling of pressure on the chest during sleep. At 5 A.M., I was awakened by a violent rigor, it lasted twenty minutes, and was followed by heat; the pulse, which had been little affected during the two previous days, increased to 78, was full and strong; skin hot; face red; thirst urgent; heat in the head; pretty strong palpitation of the heart; slight burning at the stomach; fulness and inclination to vomit; respiration very much impeded; feeling of pressure and constriction of the chest; cough frequent, and a little moister; on auscultation, the respiration appeared rougher than the previous evening, and deep inspiration was accompanied by slight pain under the left nipple. Night very agitated; nightmare; disagreeable dreams. I felt much the same in the morning as I had the previous day, but deemed it advisable not to carry the experiment further. During the subsequent days, the following symptoms occurred. The tenth day no stool; towards evening, pulse 72; respiration somewhat less difficult; cough the same; hardly any pain in the side; great thirst; a good deal of uneasiness; no inclination to vomit; night, a little less restless. The eleventh day, a little less roughness of respiration on auscultation; cessation of the pain; pulse nearly normal; skin still hot; thirst less; uneasiness diminished; appetite in part returned; respiration still obstructed; cough a little less; the night more tranquil. Twelfth day, appetite; breathing nearly free; the cough continues; still a little uneasiness; scarcely any thirst; tranquil night. The symptoms continued to diminish the subsequent days, so that by the eighteenth there remained no trace of indisposition, except slight cough, which persisted some time longer. Not being sufficiently edified by this single experiment, three months subsequently, I commenced another.
Observation 2.
During eight days, I took each morning, 5 milligrams of Tartar emetic, without feeling anything. The ninth day, at 8 P.M., I took another dose of 1 centigram; night somewhat disturbed; the respiration appeared somewhat less free, but that was not very distinct. The tenth day, on rising, a little weariness; I again took 1 centigram. During the day I had some uneasiness; mouth clammy; little appetite; breathing impeded. About 10 P.M., I took another close of 5 milligrams; sleep very disturbed, and towards morning uneasiness, especially at the epigastrium; some nausea; loss of appetite; respiration impeded; a watery stool at night; great fatigue; urgent thirst. From the morning of the eighth day the cough appeared, and went on increasing; it is short, frequent, and painful; auscultation gave no results. At 9 A.M., 1 centigram was taken. In the course of the day, rigor, which lasted half an hour, with burning in the head and beating of the heart; thirst; inclination to vomit; pulse 80, strong; skin hot; cough dry and painful; considerable difficulty of respiration; sensation of weight on the chest; auscultation shows rough respiratory sounds; general bruised feeling. This state continued all day and night, which was very much disturbed by strange and fatiguing dreams. There were two watery stools during the twenty-four hours. The following days the symptoms declined, but more slowly than the first time, so that by the twenty-fifth day I had not entirely recovered my health, 67.
A dull, wavelike pressure on the right frontal eminence, 4.
Headache from morning till 5 P.M.; a painful pressing forward from the occiput across the vertex into the frontal region, where it seems to her as if everything would come out; worse at 1 P.M. (seventh day), 1.
Pressive headache in the centre of the forehead, above the nose, 5. [90.]
For several months, a pressive, tensive pain , especially in the forehead, immediately after waking, relieved by cold water (especially the third day), 3.
Pressive pain in the forehead , more like a sticking, extends downwards into the left eye , with unusual inclination to close the eyes (four hours), 3.*
A fine tearing from the left frontal eminence toward the temple, on speaking (after one hour), 1.
Sticking (or rather tearing) in the forehead (twenty hours), from 2 P.M. till 3 A.M., 2.
Jerking and drawing, with a tension in the forehead, especially over the left eye (one hour), 3.
A sensitive pain in the right side of the forehead, the whole evening, with a sensation as if the brain pressed too hard there, balled into heavy lumps, 4.
Throbbing in the right side of the forehead (fourth day), 2.*
On waking in the night he always has the same bad headache, as if the brain were balled into a heavy lump, only in the left half of the forehead, 4.
Pressive headache on the left side of the forehead, with pressure on the eyes, 5. [100.]
Violent pulsating of the bloodvessels in the temples (fifth day), 8.
Very sensitive pressure on the vertex (fifteenth day), 8.
In the afternoon, on motion, a surging from the neck upward across the vertex, toward the forehead, with stupefaction and confusion of the senses, on standing for one minute, 1.
Burning and itching, in a place as large as a half dollar, in the anterior part of the right parietal bone, on stooping; on rising, it is somewhat relieved, but constantly returns on stooping, and disappears on scratching (after one hour), 1.
Intermittent tearings in the right side of the head, 2.
Tearing in the right side of the head, and especially deep in the right ear, on raising the head, after stooping (after three-quarters of an hour), 1.
A kind of stupefaction with a tensive sensation attacks the left half of the head (one quarter of an hour), 4.
Slight tearing, drawing headache in the left half of the head from behind forward, 5.
A tensive pressing-in headache in the left half of the skull, 4.
On stooping, several violent stitches in the left parietal bone, extending forward (after half an hour), 1.
Such a violent stitching-tearing from the posterior-inferior portion of the left parietal bone, to a place in front of the vertex, that it seems as though a piece were being torn from her head; deep within, on standing, 8 A.M.; the same pain returns on the following day, at the same hour, 1. [120.]
The occiput becomes heavy, and an anxious oppressive sensation sets in, 5.
Sensation in the occiput, on stooping, as if something fell forwards (three hours), 3.
Raging or throbbing pain on the right side of the occiput, like ulceration, on rest and motion, 1 1/2 P.M., 1.
Heaviness in the head, and the scalp is so sensitive that she can scarcely bear the comb (morning and evening), 1.
Flow of tasteless, clear water in the mouth, which runs out in great quantity, with retching and straining, without fetching up anything beyond a little clear mucus, 14.
Empty eructations relieve the nausea for a very short time, 5.
In the morning frequent eructations, with yawning, and great ill-humor (fifth day), 1.
First eructations, then frequent risings of fluid (as of food), which she again swallows, after which a sour taste and scrapy sensation down the throat remain, 4.
After dinner, qualmishness in the stomach of some duration, 4.*
Several times gagging severely, sweat starts out on the forehead, the limbs become very weak, and much water flows from the mouth; followed by weakness, 5.
An especially disgusting sensation in the stomach; she believes it would do her good to eructate; with frequent attacks of nausea in the stomach, which extends into the chest (after three-quarters of an hour), 1.
Vomiting in any position, except lying on the right side, 16. [340.]
After a violent pressure on the stomach it increases to vomiting, 5.
Retching, and once difficult vomiting of bitter, bad-smelling, pasty, and fluid matter (it had an acid reaction, and showed traces of antimony), (fifth day), 8.
Painful vomiting of much mucus and bile mixed with some blood (half an hour), 34.
Vomiting of some tough, watery mucus, then pasty food, and at last fluid mixed with bile, with most violent exertion of the chest and abdomen, and anxious sweat, 9.
Indescribable malaise in the region of the stomach and abdomen; on touching the parts gently with the hand the pain increases in the region of the stomach and diminishes in the abdomen, 14. [360.]
Sensation after dinner as if one had overloaded, with nausea, griping in the region of the navel, and sticking headache in the forehead and occiput, 2.
In the night, sensation as if she had loaded her stomach with something; eructations frequent, like foul eggs; sleep restless, 2.*
Feeling of a weight in the region of the stomach, involving the whole abdomen, and causing great malaise; this condition is ameliorated in the open air, and aggravated in the room; it is also diminished by eructations, 14.
Violent pains at the epigastrium, which was tense, 47.
Violent throbbing in epigastric region (a quarter of an hour), 3.
(Continual whirling in the pit of the stomach, evenings on going to sleep, with very violent rapid beating of the heart, which threatens to rupture the heart), 2. [380.]
Feeling as of cold water at the pit of the stomach; with it he feels faint; he will fall down; then follows heat in the head, 6.
In the region of the pit of the stomach, a sensitive aching as from incarcerated flatulence, late in the evening; sometimes forcible expulsion of flatus with relief, 4.
The pain in the abdomen, though not so very severe, is yet so distressing, that he is in an extremely restless mood, and disinclined to do any work, 3.
Must lie and stretch out long, on account of discomfort in the upper and lower abdomen; at last he goes to sleep (11 A.M.), 4.
Violent pain in epigastrium, and over the whole abdomen (one hour), 52.
The pain in the abdomen causes great restlessness in the body; one must constantly move a limb or change position, 3.
The abdomen seems stuffed full of stones, though he has eaten nothing, and it does not feel hard; a sensation that he feels after long-continued sitting at work, 3.*
Violent pressive tension in the abdomen, especially over the bladder, which decidedly increases toward 6 P.M., and lasts toward six days (second day), 3.
A kind of cramp in the upper and lower abdomen, between nausea and tendency to diarrhœa, in which now one now the other seems to predominate; at times relief from empty eructations, and inclination to pass wind, or actual passage of wind, 4.
(Spasmodic pains in the abdomen; when they begin his eyes close forcibly, and he is obliged to sleep whether he wishes or not), 2. [420.]
Gripings in the bowels, with development of flatulence, 3.
Griping and cutting, and repeated nausea, with empty eructations, and passage of flatus with relief, 4.
After a meal, violent griping and cutting in the abdomen, which is not relieved by a stool at 3 o'clock; it lasts till 4 o'clock (third day), 3.
Waking at 4.30 A.M., with some pinching and commotion in the abdomen, followed by soft stool (second day), 1.
In sitting, a crawling in abdomen, which becomes griping and flatulence, (afternoons), 3.
A transient nausea repeatedly in the abdomen, like an approaching griping, as if diarrhœa would set in, 4.
Painful drawing, now in the right side of the abdomen, now in the left so that she can only sit stooping, returning frequently, 1.
Violent pressure in the abdomen, as from stones, as if full; much worse on sitting, especially on stooping ; at times it changes into griping about the umbilical region (one hour), 3.*
The pressure in the abdomen becomes sometimes more severe, and presses toward the rectum, when soft, boiling, hot flatus passes, which relieves the pressure, 5.
Pressive pain in abdomen, in evening, after eating, relieved by bending backwards and stooping, 12.
Pinching pressure and tension in the abdomen (eighth day), 8.
Cuttings in the abdomen; and across the lower abdomen it lies like a stone, with great nausea; after six times ineffectual retchings, followed by ineffectual tendency to diarrhœa, vomiting with great exertion, trembling in the abdomen, and bending together ; first food with persistent sour taste, followed by a continued scraping feeling in the throat; afterward chilliness, then two diarrhœic stools in succession, the last time it passes like water, 4.
Cutting and griping in the abdomen, as from wind, 4. [440.]
Violent cutting and twisting in the abdomen, and tearing from the hypogastrium down through the thighs to the knees, like labor pains, with fine but severe stitches at the navel, with nausea and waterbrash; soon afterward diarrhœa, preceded by rumblings, and moving of wind in the abdomen, 4.
On drawing in the abdomen, a small spot in the left side of upper abdomen hurts, 5.
Frequent sensation of pulsating in the abdomen, 3.
Violent, rheumatic, long-lasting pain in the whole left side; this pain is repeated, 5.
A stitch extends downwards from the stomach, in the left side of the abdomen, and again upward; on expiration and on touch it aches, 4.
Warmth in the lower abdomen, as if she had drunk something very warm; it wanders about, and finally up toward the stomach (after half an hour), 1.
The tension in the abdomen seems to draw more toward the bladder on the third day, 3.
At 1 A.M., she wakes, on account of violent cramping and griping pain above the pubis, with icy coldness on the whole trunk, head, and arms; cold sweat breaks out in such profusion, that the shirt becomes drenched, with great internal heat; sensation of dryness of the tongue, which is nevertheless moist; with warm lower extremities; frightful apprehension; restlessness; she constantly throws herself from side to side; but, with sensation of great heat, cannot bear to be uncovered. After a quarter of an hour, she is inclined to eructation, without being able to; then empty eructation and small discharge of flatulence, without relief; thirst; rising of water into the throat, with great nausea in the stomach; paleness of the face; on the lower extremities warm sweat; and such great lassitude of the feet that she is unable to raise them; inclination to stool; hardness and sensitiveness of the lower abdomen on rubbing; even long before this, she felt the pain while asleep. (After a small dose of Ipecac, the sweat disappears, after quarter of an hour; then the coldness, and lastly the pains, which occur at longer and longer intervals, till they disappear altogether), (after half an hour). After cessation of this frightful attack, she slept soundly; 6 A.M., on waking, heaviness of the head, and appearance of the menses; blood thick and black; they are too soon, but without any other difficulty, and last as usual, three days (fourth day), 1.
(Spasmodic drawing from the thigh to the abdomen), 2.
Pressure in the hypogastrium and aching, with cold shivers, as if menses would appear, 4. [460.]
Urine turbid and dark at first, afterward clear, 5.
The urine at first clear like water, deposits a milky sediment, which mixes readily on shaking the glass, and gives a milky look to the whole (fourth day), 3.
The urine becomes cloudy, and deposits an earthy sediment (first day), 1.
The urine deposits a violet-colored, earthy sediment (after one and a half hours), 1.
On coughing, heat and moisture of the hands, and sweat of the head, 2.
On the back of left hand, on touching the hairs, fine severe stitches.
Tearing and stitching in the border of the left thumb, so violent that it seems as if the tendons would be torn out (9 A.M.), 1.
When she wants to clench her fist, or extend the fingers, they are tense, as if swollen (4 P.M.), 1.
Fingers firmly contracted down upon the shoulders, with every muscle in an extraordinary state of rigidity, 52.
On the lowest joint of the right middle and ring fingers, frequent violent pinching pain, with sensation as if the tendons would contract; still, motion remains free (fifth day), 1.
Stitching in the lowest joints of the left middle and ring fingers, as from a thistle, worse on pressure (sixth day), 1.
Twitching, tearing below the right third finger, as if in the marrow, extends towards the arm; disappears only gradually, in the afternoon, 1.
Tearing on the back of the left middle finger, as if it would tear out the tendon (for one minute), 1. [700.]
The tips of the fingers become dead, dry and hard, without sensation, several days, 3.
After vomiting, great weakness, fatigue, and sleepiness , disgust for all the customary food; pale, earthy face; swimming dim eyes, yet appetite for cooling things, like apples, 4.
Such great general weakness, and so warm about the heart, that she must let the arms sink down, 4.*
The right and left sides of the upper lip are full of clear, itching vesicles, which, on drying up, are replaced by new ones; the itching is especially violent in the evening, 1.
On the right side of the lower lip several clear vesicles; at the same time the right side of the upper lip is swollen, and covered with small pimples, with tensive pain on pressure, 1.
Eruption of pimples like pocks on the side of the chin; tickling sensation; must rub it, 2.
Two boils behind on the right side of the tongue, painful on touch, 3 P.M., 1.
A boil behind on the left side of the tongue, which pains as if sore when she presses it with the tongue, or on swallowing (from the morning after rising till evening), (second day), 1.
Several burning blisters on the left side of the tongue, which soon disappear, but return a day later (sixth day), 1. [820.]
Itching below the right corner of the mouth, where, after scratching, three vesicles arise; also under the left corner (second day), 1.
Skin from waist to knees covered with an infinite number of small pimples, which itch intolerably; she is compelled to scratch till the blood comes; external genitals much swollen, 39.
Frequently observed that when the pustular eruption was very copious where the ointment was applied, similar eruptions developed on the genitals, 39.
Pustules developed on the scrotum , five weeks after the removal of an antimonial plaster, from between the shoulders, 39.
Large pustules on the chest, like cow-pox, with a red areola; after three weeks it is covered with a crust and leaves a deep scar, 25.
Several small pimples on the upper part of left side of the chest, and a similar one on the right side (eighth day), 1.
A red, somewhat swollen, streak, two inches long, on the left side of the neck, without sensation, which does not disappear on pressure, but lasts twenty days, 1.
Violent itching in the left shoulder; after scratching, a number of small vesicles arise, and she must scratch till they bleed, without relief to the itching, whereupon the spot burns; the vesicles dry after three days, 1. [830.]
Itching on the anterior surface of the right upper arm; after scratching, small, deepseated pimples appear, which continue to itch (third day), 1.
On the forearm, near the wrist, an eruption of pimples, like the itch; also on the upper arm; the itching is relieved by scratching, 2.
A tetter, as large as a penny, on the inner surface of the left forearm, which disappears after three days, but returns after eight days, and itches violently, especially when scratched; the place remains rough for some time after, 1.
Small, red, elevated spots, like flea-bites, appear on the hands, without pain, and disappear after two hours (fourth day), 3.
Dark-yellow spots of large size appear on several fingers, remain two days (fourth day), 3.
On each buttock three or four tensively paining pimples, which pain like a boil on pressure, and last four days, 1.
Voluptuous itching below the right calf; after scratching, a number of deepseated pimples arise, which do not cease to itch till scratched bloody, and then the place itches and burns for a long time (second day), 1.
Itching below the left calf, which causes scratching, after which a considerable lump arises, which continues to itch, 1.
A crawling itching in the sore itself (evenings on lying in bed), 2.
Itching below the left lower jaw, which disappears on scratching, 1.
Voluptuous itching in the nape of the neck, which causes scratching, till the blood comes, on which it does not disappear (7 P.M.), 1.
Itching on the middle of the right shoulder-blade, 1.
Itching on the external surface of the right upper arm, just above the elbow, which disappears on scratching (10 A.M.), 1.
Itching on the external surface of the right elbow, which disappears on scratching (after three and a quarter hours), 1.
Itching on the inner surface of the left forearm; after scratching, a number of small pimples arise (in the forenoon), 1. [850.]
Violent itching on the external surface of the left forearm; on scratching, small pimples appear, which burn, and the skin becomes rose-red, but white on pressure; the redness continues two hours (6 P.M.), 1.
Violent itching in the palm of the left hand, which disappears on scratching (after one and a half hours), 1.
Burning itching on the inner side of the left thigh; after scratching, pain as if sore, and on touch as if bruised (6 P.M.), 1.
Itching on the front part of the left knee, which disappears on scratching, 1.
A painful biting-itching in the leg where there are varices, as if a suppurating inflammatory swelling would ensue, 2.
An itching and biting in the right sole, so that he must scratch, evenings in bed, 4.
He lies on his back in sleep, the left hand under the head (nine hours), 2.
Somnolence; the eyes close involuntarily; he sleeps with the head held erect; so fast asleep that he did not wake when the eyelids were separated (pupils were found contracted); with moderate warmth of the hands and face and quiet breathing; only for a few minutes roused by the occasional efforts to vomit (one quarter of an hour), (child), 5.
He talks much in his sleep, plainly and coherently, 2.
He has to lie in bed till 1 o'clock at night before he can get asleep, and then lies merely in a dreamy state; he seems to be obliged to wade in deep water and cannot get out, 2.
He gets asleep late and with difficulty, and often wakes and tosses about, 2. [890.]
At night the child screamed out of sleep, with staring eyes; *trembled, it drew up its arms and feet, 2.
He had scarcely fallen asleep when he was seized with electric shocks and jerks , all of which came from the abdomen; it threw now one arm now another away from his body; now a foot; now it threw the whole body into the air, 2.
Sleep; remained restless and dreamy a long time, 8.
Sleep restless, with many confused heavy dreams (eighth day), 8.
Extremely restless sleep the whole night; she wakes often from anxious dreams, with dryness in the mouth and cracked lips (fourth day), 3.
Troublesome dreams, with nightmare all night, 10. [910.]
The first night he dreams continually of bright glowing fire, from which he must frequently fly; the fire breaks out all around wherever he goes, still it does not burn up the house; the second night he preaches without having memorized and "gets stuck;" this occurrence worries and makes him anxious, as on the previous night, the larger part of the night, 4.
The whole body breaks out into a cold, clammy sweat (15 grains), 19.*
(
( Before rising from bed ), Pain in small of back; rheumatic, etc., sensation in limbs.
( On rising from bed ), Pain in small of back; rheumatic, etc., sensation in limbs.
( Rising from sitting ), Flickering before eyes , etc.
( In room ), Raging, etc., in whole head; feeling of weight in region of stomach, etc.
( Rubbing ), Burning in left breast.
( Scratching ), Vesicles arise at the mouth; vesicles arise on shoulder; pimples on left forearm; itching on left forearm; itching below left lower jaw.
( Sitting ), Immediately, pressure in abdomen; the attacks; pressure in abdomen, etc.; pain in back.
( After sitting down ), Immediately, feet go to sleep.
( Sitting down after moving ), The pain.
( During sleep ), Profuse perspiration.
( After violent sneezing ), Pain in chest, etc.
( Speaking ), Tearing from left frontal eminence, etc.
( Standing ), 8 A.M., stupefaction, etc.; stitching-tearing from parietal bone to vertex; right foot goes to sleep, etc.
( Stooping ), Burning, etc., in right parietal bone; stitches in left parietal bone; sensation in occiput as if something fell forward; stitch in right lowest rib.
( During stool ), Cold shivers through the skin.
( After stool ), Burning in anus.
( After supper ), Malaise.
( Swallowing ), Pain behind root of tongue; saliva nausea.
( Talking ), Pain in larynx, etc.; hoarseness.
( Touch ), Eyeball pains; stitch in abdomen aches.
( Touching parts gently with hand ), Pain in region of stomach.
( Touching the hairs of the part ), Fine stitches.
( Turning neck over left scapula ), Aching in neck.
( After urinating ), Burning in urethra.
( After vomiting ), Pains in abdomen; great weakness, etc.
( On waking ), General fatigue.
( After waking ), Pain in forehead.
( Walking ), Totters; tension in perineum, etc.; drawings through right hand, etc.; tension on dorsum of foot.
Amelioration.
( Open air ), Head heavy, etc.; raging, etc., in head; feeling of weight in region of stomach.
( In bed ), Twitching tearing in right concha.
( Eating bread ), Soreness, etc., in palate.
( Cold water ), Pain in forehead.
( After cough and expectoration ), Feeling of suffocation.
( Eating ), Sour taste on back of tongue; feels better; pressure in abdomen.
( Eructation ), Nausea; pressure in stomach; cramp in abdomen.
( Lying on right side ), Vomiting.
( Moving about ), Pressure in abdomen.
( Pressure ), Boring in right humerus; twingeing in left forearm.
( Passage of flatus ), Nausea; aching in pit of stomach; distension, etc., in abdomen; rumbling in abdomen; rumbling, etc., in bowels; pressure in abdomen; griping in abdomen, etc.
( Rising after stooping ), Burning, etc., in right parietal bone; tearing in right side of head; pain in upper chest.
( Scratching ), Burning, etc., in right parietal bone; itching in right elbow; itching on upper arm.
( Standing ), Pressure in abdomen.
( Touching part gently with hand ), Pain in abdomen.
At 6 P.M. she complained of pain in the lower part of the left side, and retired to her room, where she was immediately attacked with vomiting, followed after several hours by purging, both of which continued, accompanied by burning in the mouth, dryness of the throat and great thirst, 61.
Lethargic expression of countenance; conjunctiva slightly congested; general surface of body cold and clammy, with a bluish-pale appearance; voice weak; speech slow and deliberate; vomiting and purging; violent cramp in the legs, 62.
After the experiment of Dr. Mayrhofer (Heller's Archiv. 1846) [Unfortunately inaccessible. -T. F. A.] I began with the smallest possible dose, 1 mlgm., and gradually increased to 0.013 grm.
September 1st, 1866. I took a solution of 1 ccm., diluted with distilled water to 10 ccm., so that every ccm. contained 1 mlgm. of Tartar emetic. Pulse 73. I took 1 ccm. at 8 A.M., two hours after breakfast. After an hour, not feeling the slightest change in my condition nor in the rate of my pulse, I went about my business. 3.15 P.M., I took 2 ccm; pulse 71. After about three-quarters of an hour I felt rather uncomfortable for a short time, pulse rose to 72 or 73, and after the disappearance of the discomfort, returned to 71. My appetite at evening was unchanged.
September 2d. 8 A.M., pulse 73 took 3 ccm. After forty-five minutes some discomfort, which disappeared after twelve minutes. Appetite normal. Pulse 71, after twenty minutes.
September 3d. Took at the usual hour 4 ccm. Pulse 72. After forty minutes slight headache, nausea, and very acute sticking pain in the epigastric region, which disappeared after a quarter of an hour. Pulse 74; half an hour afterwards 70; after half an hour's quiet work 68. Appetite at noon diminished. 3 P.M., injected a strong solution into the left thigh, 1/2 ccm. Pulse 73. After five minutes there was vivid redness, associated with burning pain at the point of injection, which I relieved by cold applications. Pulse 75. Ten minutes afterwards I experienced violent heat, headache, nausea, weakness, which gradually increased, till after ten minutes more sweat broke out. Pule 79. I was very much exhausted, felt great need of rest. Pulse after fifteen minutes 72. After another quarter of an hour 67. After walking about the room the pulse rose to 73, but soon fell to 68. In the evening I took very little food, and then felt constant burning in the throat, even swallowing caused trouble. Increased thirst, sleep broken.
September 4th. On waking I felt slight headache in the skull, and had little appetite for breakfast. I took a concentrated solution, less than 1/2 ccm., about 8 mlgm. Pulse 71. After thirty-eight minutes there were the first symptoms of discomfort, which soon disappeared, but ten minutes later returned with increased violence. Very disagreeable sensation in the pit of the stomach, which was distended. It was very sensitive to touch, not unlike a sticking. Constant recurrence of yawning, eructations, and rumbling in the abdomen, which alternated with each other. I felt a burning heat in the head, with alternations of chill and heat. There was a feeling of coldness in the hands and feet. Pulse 74. After fifteen minutes this condition entirely disappeared and gave place to weakness, weariness, and prostration of the limbs, so that I could scarcely rise from my chair. Pulse 70. Nausea continued, the whole day, associated with a very disagreeable taste in the mouth and copious secretion of saliva. I ate scarcely anything all day. The persistent weakness caused me to go to bed earlier than usual.
September 5th. Rose with chill, headache, and weakness of the limbs, otherwise well; took at 8 o'clock 1 ccm. of a solution, about 1 cent. grm. of Tartar emetic. Pulse 70. After half an hour there came on nausea, yawning, eructations, rumbling, pain, and pressure in the epigastric region, accelerated respiration (20), headache, burning in the throat, difficult swallowing, accumulation of saliva in the mouth, chilliness, weakness, and retching. Pulse 75. These symptoms gradually diminished, and disappeared entirely within half an hour. Only dulness of the head an weakness remained. Pulse 69. I had a most violent aversion to all kinds of food, and had scarcely eaten the soup at noon, the swallowing of which was very painful, when most violent retching came on, but without vomiting. A disagreeable taste in the mouth obliged me to drink much cold water all day, which afforded some relief to this symptom and to the difficulty in swallowing. Weariness drove me early to bed, and I slept well all night. The next day I was prevented from continuing the proving. I had no remarkable appetite; the epigastric region felt painful; the headache persisted, but only in a slight degree. The difficulty of swallowing was considerably relieved. The proving was also omitted on the seventh.
September 8th. Feeling perfectly well, at 8 A.M. took 1 ccm. Pulse 74. After thirty minutes I felt the first indications of nausea. Pulse 79. With the increasing nausea the pulse rose to 84. Violent retching, chilliness, perspiration, and vomiting of the remains of the breakfast. Pulse 88. With increasing weakness and with diminution of the nausea the pulse feel to 71, and half an hour later to 67. At noon I experienced most intense aversion, becoming qualmish on even looking at food. During the day I suffered from headache and pain in the abdomen, the latter increased in severity by the slightest movement. At night I slept little and very uneasily.
September 9th. I awoke with dull headache and burning in the vertex. At breakfast had little appetite. Pulse 69. I took a solution of 12 mlgm. After thirty-four minutes I experienced first the nausea, the epigastric region became swollen and very painful. Pulse 72. These symptoms disappeared, but returned more violent after five minutes, and were associated with a disagreeable metallic taste, accumulation of water in the mouth, burning in the throat, coldness of the extremities, retching, chilliness, sweat. Pulse 77. In order to relieve the flat taste, I drank cold water. The pulse fell to 72, but soon rose to 79. The symptoms disappeared completely after an hour and a half. Pulse 72. Only the weakness, dulness of the head, and pain in the throat returned. After an hour and a quarter I counted 65 weak beats of the heart. Through the day I had copious secretion of saliva and no appetite. On the following days I was prevented from continuing the experiment, but I was extremely weak and prostrated. The eyes were surrounded by blue rings, and lay deep in their sockets. The headache left me for only short periods. The difficulty in swallowing had entirely disappeared. Pulse 69 and 70.
September 12th. I made a new experiment; I injected a solution directly into a vein. For this purpose I took a concentrated solution, and injected it into a superficial vein in the left forearm, 1/2 ccm. of a strong solution, amounting to 5 mlgms. I had scarcely emptied the syringe when I experienced a raging headache, saw sparks of fire, had burning heat in the face, and distressing pressure in the brain; at the same time there was violent præcordial anxiety. I suffered from dyspnœa, it became black before the eyes, I reeled, so that I was obliged to sit down; I vomited green masses with great effort. At the same time there was very free hæmorrhage from the place of the injection, which was stopped only by persistent compression. Through the day I felt very weak, as after a terrible illness. Unfortunately it had been impossible to count the pulse, on account of the violence of the symptoms.
September 13th. Headache and pain in the stomach continued; there fore I took only 7 mlgms., after which there was nausea but no vomiting. The pulse rose within thirty-four minutes from 75 to 79, and an hour later fell to 70. Little appetite. On this day slight diarrhœic stool.
September 14th. I injected about 1 1/4 centgm. into the left forearm. Pulse 68. There was immediately violent burning at the point of injection, which became very red. The face became hot; I experienced violent headache in the vertex and pressure in the brain, and a very anxious sensation in the pit of the stomach, nausea, retching, chilliness, and after twenty-five minutes vomiting of green masses, with outbreak of copious perspiration. Pulse 80, very small. The whole day I was very weak and unfit for any effort. On the two following days I could not make any experiments, but the headache continued, there were sensitiveness in the epigastric region, complete loss of appetite, and diminished power of digestion.
September 17th. In the morning I drank 1 1/4 centgm. The condition was tolerable. Pulse 72. After half an hour symptoms previously observed returned. Pulse 83. Headache and weariness lasted through the day. Sleep at night short, restless; diarrhœa.
September 18th. In spite of the unpleasant remembrance of the former injection, I attempted it again, injecting 3/4 centgm. directly into a vein on the left forearm. Pulse 75. This was followed by frightful headache, heat of the face, vision of sparks, very anxious sensation in the stomach, in short, the same symptoms as after the former injection. On this day I examined my urine with Nitric acid and under the microscope. After the Nitric acid there was slight turbidity, and I found under the microscope desquamated epithelium of the uniferous tubes. This appearance of albumen in the urine warned me, on account of Maryrhoffer's proving, that I must discontinue further experiments on myself. The turbidity of the urine lasted two days; the pain in the stomach and head and difficulty in swallowing disappeared after three days, and the appetite returned. But even after two months there were frequently recurring troubles in digestion, reminding me of my proving. It was noteworthy that during the proving I lost seven pounds in weight. 63.
Immediately experienced a metallic taste in the mouth. In a short time she felt sleepy and powerless; black specks floated before her eyes, and she had to go to bed, where she lay rolling about and became faint, with cold perspirations. At 3 P.M. she vomited her dinner, and was purged, and again vomited two or three times. She had pain in the lower part of the abdomen, with severe cramps in the lower extremities. At 5 P.M. she was in a state of extreme prostration, with tetanic spasms of the legs. With great difficulty the legs were straightened, which gave great relief. She suffered from enteritis for about three weeks, and gradually recovered. The only other effect of the poison was that the hair began to fall out soon after the illness. She is now alive and well, but the air on the crown of her head is very thin, 63.
Violent vomiting; violent and frequent recurring cramps of the legs, relieved by forcible extension, 66.
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