Ferrum phosphoricum

Volume IV — Appendix

FERRUM PHOSPHORICUM ALBUM.

^- '"X'his is said to be a true ferric phosnhatejFc5(PO,)3 or Fc"jPjO, as contrasted 11**^ the ordinary phosphate of iron, which is a' ferrous. hydric phosphate, H-Fcj '^).or Fc"HPO,. (It is the " Fernim phosphoricum " employed by Sehijsskr.)

.J. Provings. — Dr. John L. Moffat furnished to 10 persons five ^.* ^~oz. bottles, without name, marked A, B, C, D, and E, and con- ^>"ing respectively sugar of milk, 30th, 6th, and i, trits., and the ""dc drue^ ~

The following are the results :

'. a. P. C. Mori ARTY, set. 21, in good health, save for some nasal

^*-^fTh, June 7th, 1887, at 10 a.m. took 10 gr. of A. Almost

'rarriediately, sensation as of pinching in 1. temporal region from within

^ard. This recurred after a second dose of 5 gr. at 10. 30. At

*3o dissolved 5 gr. in half a tumbler of water, and took a dose every

5 •*!. Nothing further was noted this d., or on 8th, 9th, and loth,

save some coryza between 7 and 8 p.m. On 15th took 5 gr. of same 4 times. 16th.—Feeling of dulness and heaviness of eyelids, especially r. 17th and 18th.—Same, and on latter d. great fulness also of whole

eyeball, and feeling of dryness and roughness of lining of lids. This feeling had increased on 1gth, and continued about the same on 20th and 21st. Eyes were then examined, and found congested, Alumina was given, and by noon on 2and improvement had st in

4, On 23rd E. was commenced (by mistake for B). Five gr. were taken at 11.30 a.m, and at 2 p.m, same dose was mixed with water, and taken in four portions, Very drowsy all d, 24th —Stool this m. dark green, no odour. At n, had tossed about for 4 d., exceedingly restless and quite feverish ; but when sleep came it’ was heavy. agth,—Stool a shade lighter. Urine, p.m. and e., had odour as of café au lait, and was copious. 26th.—Stool rather dry, natural colour, but here and there spots of dark matter ; much hot flatus passed just before it, Urine quite copious, inodorous. 27th.—Tinnitus, buzzing and ringing, interfering with hearing, all p.m. and in early e, 28th.— Buzzing in ears, p.m., but not so marked as yesterday, On July gth and 17th prover took 5 gr. four times [or in four doses, it does not clearly appear which—Eps.], with no effect, save on colour of stools. On Aug. 1st took same. Very drowsy during m. (1st dose taken 7 am,” and—Took§ gr. at §11yand 2. Much drowsiness during m,, with continued rush of thoughts, suddenly turning from something pleasant into the most vivid impressions of some crime being come mitted or horrible accident occurring, but not to myself." Slight buzzing in ears about 2 p.m. 3rd.—Vivid dreams during n., quarrelling with one person and the next moment happily conversing with another. Stool very dark greenish and quite hard, rather dry and expelled with much effort. Experienced an aching, dull pain in'r, testicle about 11 a.m. lasting about 20 m. Yesterday and to-day I have been absolutely devoid of sexual instinct, 4th.—During n. had very realistic dreams, mostly quarrelsome in character. Stool this morning very dark, but not exactly green ; it looked as though a black mud had been mixed in with it; was not so hard as that of yesterday 5 sexual system same. th.—Stool natural except one portion, which was mixed with the dark green fecal matter before alluded to. Sexual system same, 6th.—These two d, past have had continual hawking of viscid, tenacious, colourless mucus from low down in throat and from the posterior nares, Commencing Aug. 3rd, I noticed a profusion of acne, very sore, about my chin and forehead, which grew worse until to-day; at present writing they seem to be fading away. Before making this proving I had, off and on, more or less acne about the face, but never so profusely as that which caused me to note the symptom. 12.30p.m., § gr. Drowsiness; sexual system same ; profuse urine, 7th.—Stool very dark muddy green. Continual hawking of mucus, Yesterday, and to-day also, have had dull aching pains in heart (as though in anterior walls), which moved from spot to spot and were something like stitches, but not so sharp; it was rather a “blunt” pain. Acne fading; urine very profuse and watery all d. 5 sexual feeling still absent, 8th.—Stool half normal, the other half dark green, Several times during d, dull, aching pains in heart, Urine profuse but not so pale, ‘There has been increasing dryness of margins of lids for several d., but it was not very annoying until to-day.

ntinual hawking of mucus ; sexual system same. 9th. — Stool almost

normal now; pains in heart very slight ; urine not so profuse; lids

quite dry and rough j slight sexual feeling. I was asking questions of

repeat my questions several times ; and finally I

who was present) if he could hear distinctly

saying, for I could not. He replied that they

a patient, and had to aslced my preceptor, what the patient was

were talking very plainly, and that he had noticed my deafness for 4 or 5 d. past, but had not made any comments upon it, as he wished to see whether or not it was a proving. To-day there was a terrific and continual hawking of mucus, which was very annoying; it was very frothy and felt as though I was going to raise a bucketful, but instead of such profusion it would simply be a little watery, frothy and sticky tnucus. lOth. — Stool normal; urine apparently normal ; acne almost gone ; sexual feeling still slow about being excited. It was very annoying to converse to-day (as it has been for several d., but heretofore I blamed the other party for not speaking above a whisper) ; the deafness continues, but is not quite so bad as it was. The trouble of raising frothy mucus was very annoying, but seems to be declining in intensity. Slight frontal headache, lasting about 2 h. this e. nth. — Stool and urine normal ; sexual system about normal ; bearing much improved ; some mucus raised to-day. 13th. — Took 5 gr. at 10 and 2. Drowsiness during afternoon. 14th. — Stool dark green. 15th. — Stool same. Took 5 gr. at io, 11 a.m. and 2 p.m. Much drowsiness during m. accompanied by exceedingly unpleasant thoughts ; tried to turn thoughts to something pleasant, but some horrible image or accident was sure to come into the scene ; then I got angry for allowing my thoughts to run on this way, and endeavoured to occupy my mind with something else, writing, reading, &c., but invariably with the same result. This turn of thought was only noticeable during the drowsiness in m. Dull, aching pains about heart, sometimes extending into muscles of back, 1. side of spine. Urine very profuse, watery. Very marked thirst during latter part of d. for large quantities of cold water at frequent intervals. During e. continued hawking of mucus came on ; coughed very hard to loosen it, and would raise a little watery, frothy mucus. Dull, aching pains over kidneys, especially 1. Have had a continual run of acne on the nose, fading from Aug. 9th to 13th ; on 14th they began to show themselves again. They are very sore and slow to suppurate, like that on the rest of the face. i6th. — Stool very dark green, undigested. Very restless sleep during n., disturbed by constant dreaming ; drowsiness during m. with continual rush of thoughts, being in character similar to those at other times during the proving. Dull aching pains in region of the heart, Quite a profusion of acne about chin and forehead, small but very angry and sore j slow to suppurate. Had dull frontal headache during afternoon, seated mainly under frontal eminences. Mucus hawked continually during latter part of afternoon and e., getting worse as e. advances ; thirst for large quantities at frequent intervals ; frequent micturition, not quite a> profuse as heretofore, but having a strong odour. Had to-day taken 5 gr. at 10, 12 and 2. 17th. — Sleep disturbed by continuous drcami. Stool rather hard and undigested,

»ng> very

ing

S90

mud. Took 5 gr. at 10, II, 2 and ^

marked this m., thouehts runnins about tl that they were turbed. but not

thoughts runnmg even more marl

annoying.

rkedly as to-day : and buzzing in ears, and for rest of d. I ci For 3 or 4 d. past I have had vertigo on but it was not very severe until to-day ; on rising or turning I become actually si reason is leaving me. Much acne about Urine very frequent, profuse, rather dark a colour darkens toward n. Not so much d aching pains in heart and slightly in ch thirst for frequent, copious drinks, i8th,i last n., much tossing about, and was anno; ing my chest or abdomen (it was not pai sleep was restless and accompanied by vi buzzing in ears with deafness. Stool much undigested matter. Took 5 gr. at all m., with wild thoughts, thinking of t then the usual horrible interruption to headache (dull, heavy, in frontal eminen lasted for remainder of d. ; also had vio this latter was not painful, but the throbbii hear the heart-beats on the pillow. Con loth, writes; "Have since tried to heal "all broke up" this afternoon, and had si sheet iron (or hard substance) was lying bcti neum and abdominal integument. Dull sensation of hard sore spots all over chest Appetite failing very plainly. Thirst for" intervals, e. Had quite a fever during e., severe vertigo would come on ; twice duri 19th. — Very restless during n., sleeping next. In m. attempted to get up, but h an attack of vertigo which made me stupii time and used ail my will power, but work, and I returned to bed ; had no ai Experienced same hard feeling over abdoi sore spots over chest was very severe ; stomach felt hard and "set.' Considd Felt very drowsy during m., but could not accompanied by a stupid feeling, but not doctor called — as neither he nor I attril proving he made no special note of my s the best of his recollection, as follows : F touch ; eyes somewhat injected ; very ra dull, almost white coating; pulse full ai) 99 i°. He prescribed ferr. phos.> but in (This note made on 24ch.) At noon ate prunes, but did not relish them. Got upi

dizzy ; urine was dark and strong in odour } had a stool ^ h. later, which was muddy green and mostly undigested } felt very weak after it, and had considerable griping for about 5 m. About 5 p.m. I began to dress myself, but the exertion of lacing my shoes made me so weak that I had to sit still for a while. Ate nothing for dinner, but was very thirsty from this time on through e. About 7 p.m. I went to my {Hvceptor's office, and shortly afterward I felt very feverish and weak } quite a perspiration broke out from head to foot. During latter part of afternoon had very severe dull aching pains in heart, and feeling of a layer of hard substance in abdomen gave way to sensation of hard spots here and there ; the feeling of hard spots over chest continued, but was much more severe. Was almost prostrated by effort of undressing. There was a great deal of buzzing in ears and difficulty in hearing, more especially in latter part of d. During early part of e. hawked a great deal, but did not raise as much as usual. 2oth. — Last n. tossed and twisted for 2 h. before sleep came, had to throw off bedclothing and could hardly bear to keep on mv night-shirt, for it annoyed me to have anything touch my chest or. abdomen. Sleep was very restless, but more satisfying than that of n. before. On rising this m. a dull frontal headache ; not very much vertigo. Urine not so dark, and not so strong in odour as yesterday. Stool quite large, very dark greenish, and mixed with pieces of prunes (eaten yesterday). A few m. after stool an agonizing cramp came on ; the griping lasted just 50 m. I did not move during this time, but lay '* stiffened out," and so *' sick '' with the pain that, although I felt like it, I could not cry out. Especially during latter part of d. I was much annoyed by the **■ hard spots " sensation in abdomen, but same feeling in chest is more severe and painful j now and then I will have dull aching pains in heart, but not so badly as before. Was not so drowsy this m., but the dull frontal headache continued throughout d., getting worse toward n., being i^gravated by motion and accompanied by very marked throbbing through neck to occiput. Had some slight appetite at lunch-time, but did not relish food j at dinner I was hungry and enjoyed a very fair meal. Had a great deal of thirst during e. ; towards e. I began to feel weak, and slightest exertion would tire me out, forcing me to remain absolutely quiet to regain my breath. On the whole, however, I am feeling much better to-day. I did not have very much buzzing in my ears to-day, but my hearing is still quite defective. Very little hawking of mucus to-day. 21st. — Last n. was annoyed by touch of bedclothing, but not to such an extent as heretofore, and, although ■quite restless, succeeded in sleeping much sooner and slept better than usual i woke rather refreshed, a slight frontal headache, but very little vertigo, being noted. Urine natural in quantity and colour, and of very little odour. Stool of natural brownish colour with spot of dark greenish matter, followed by cramps which lasted about 5 or 6 m., but were not unbearable in intensity. Appetite normal. Headache grew worse toward n., but even then was slight. Once in a while I would have the **hard spots" feeling in abdomen, and in chest it is still rather marked ; the heart pains are seldom felt. Some fever and restlessness toward n., but thirst was not so fierce and vieakxvcM ti.<A «

marked. 22nd.—Rested very well last n., fairly good sleep. Stool normal and followed by slight cramps. For past 5 or 6 d. all sexual instinct seemed dead, but to-day there has been some excitement. My scalp has been very tender for a couple of weeks and has been getting worse, but in the past 2 d. it has become hardened (to sensations of tenderness); I have lost considerable hair and a little from my face, which may not be due to the drug effects, but as I cannot account for it otherwise I note it. There are but two inflamed spots on my nose at present and very little acne about face. Very little restlessness this e. 23rd.—Slept very well during n. To-day accidentally pricked my finger with a needle; the blood, pale and thin, flowed in almost a stream, and fully 10 m. elapsed before I could stop it. Off and on I experience the “hard spots” sensation in my chest, but it is not so unbearable as formerly. 24th.—My weight to-day is 15½ lbs. less than at the beginning; allowing a goodly amount for the hot weather there would still be an evident loss of flesh. (Trans. of N. Y. State Hom. Med. Soc., 1889.)

1. a. M. Cooke, M.D., on May 7th, 1888, took B. No symptoms. 8th.—Of C took three 4 gr. doses daily for 2 d. Throat slightly sore, l. side, in e. On waking next m. throat feels swollen and stiff, deglutition painful, < empty swallowing. Took no more of drug. Throat seemed gradually > during d., but head toward e. had dull ache and felt as if I were taking a cold. Next m. throat very much worse, nose running, and all the usual signs of a severe cold in head. Head ached so badly that at noon I took bry., which quickly removed the headache, and the cold disappeared in a d. or two. One week later, feeling well, resumed C as before, and after 2 d. had same sore throat, left sided, < a.m., wearing off during d., with symptoms of cold in head following—heaviness in head, watery followed by muco-purulent bland discharge from nose. A year ago when taking the drug I had much the same symptoms, which I attributed to other causes than the drug.

b. D was taken in same manner. Stye began on lower margin, l. eye, near outer canthus. I stopped drug when redness and swelling became marked. Some years ago was much troubled with styes on both eyes. Supposing this to be a return of the old trouble, I took bell., and by 24 h. the redness and swelling began to abate, and finally disappeared without suppurating as they had always done before. On recovery tried D as before; started another stye on l. upper lid near outer canthus. Stopped drug and resolved the stye with bell., still being under the impression that it was the return of an old trouble. In a few d. after resuming D a third stye appeared on lower l. eyelid near inner canthus. This time I stopped the drug and took nothing else; the stye resolved without suppurating in about the same time as the other two.

c. Oct. 21st.—Feeling well in every way took B, 3–5 gr. doses for a week; no symptoms. Took C Oct. 29th, Nov. 2nd, 3rd, 4th—6 doses a d. 2nd.—Fulness, sensation in head as though too much blood there (weather warm and relaxing). 3rd.—Arose with same feeling in head, most in l. frontal region, hardly amounts to an ache.

Throat a litde sore, raw, < empty swallowing, < 1. side. These feelings gradually wore away during d. as weather grew more bracing (I remember that I sat in a draught yesterday). 4th. — Throat still a little raw ; wrists ache, with loss of grasping power ; pain among tendons of wrist on shaking hands.

tLOfD took, Nov. 5th, 5 doses. Symptoms of throat decreasing. 6th, 6 doses i 7th, 2 doses; 8th, 5 doses; 9th, 6 doses. 10th. —

4 doses. Continual aching pain about carpal head of r. radius, < on using fingers or thumb, especially thumb ; certain amount of inability to grasp objects, with sudden darting pain on using force. Crampy pain (last e.) prevented my holding pen tight or pressing it on paper. I ith. — 3 doses. 1 2th. — 5 doses. Pain in wrist and weakness of prehension are disappearing; are most noticeable 10 to I2 a.m., and at 9 p.m.

e. Of E took, Nov. 13th, 6 doses. Nose feels very much stuffed up, < r. (not aware of any exposure to cold). 14th. — 4 doses, nose beginning to run. 15th. — -6 doses. Mucous discharge quite free ; last evening took allium cepa. This a.m. less discharge, nostrils open. This p.m. severe dull headache over outer side of r. eye. i6th. —

5 doees. Still have pain and loss of power in r. wrist ; pain < from being kept long in one position, also when using ; cannot lift as strongly as ordinarily. Drug finished. Nov. 25th. — Pains, &c., in wrist disappeared. No further symptoms. The wrist symptoms I do not remember to have had before. (Ibid.)

1. W. S. Rink, M.D. Began June 6th, 1887, with A, 10 gr. n. and m. for 4 or 5 d. No results. Then took B, 10 gr. n. and m. Took nearly whole bottle (5ss). On nth, papule on back of neck, very sore and itchy, hard base. In a few d. there appeared over r. eye (forehead) a sensitive swollen spot with red centre. Small papules (acne) with hard base, on forehead, very sensitive to touch ; some of the papules becoming pustular. R. hemianopsia, transient, e.g. ** detach (ed)." This never before or since. Erysipelatous redness of tip of nose extending toward forehead on 1. side ; it was shiny, swollen, hot, with aching pain < on touch, very sensitive, especially just under tip, followed by removal of a small slough from just within and under the apex (1. side), > began after removal of slough. Bodily temperature was increased and I felt indisposed. I now stopped the drug ; had begun C. (Never before had nasitis. Have had pustules occasionally, but never so sensitive or in such amount.) {Ibid.)

2. a, D. Simmons, M.D. May i8th, 1887, took A for one week without getting any effect. 2Sth. — Took B for one week with like result. June 5th. — Took C. After five or six doses had an ache and soreness in r. hip and thigh ; very sore and painful when sitting so as to produce pressure on the part ; could not sleep on r. side while soreness remained. Urinated frequently day and night, copious, light lemon colour. Stopped proving until the ache in hip and thigh ceased and flow of urine returned to normal quantity and colour, which was about 36 h. After first 12 h. without the drug, there was a reaction, and I only passed urine twice in 22 h. ; then everything began to come right, so that in a few h. more the urine was normal in quantity and

VOL. IV. 38

colour. After again taking five or six doses the trouble in hip am thigh and that with urine all returned ; stopped proving for 36 h., an the symptoms all left again. After taking it for the thira time, fo

3 d., a powder — 5 gr. — about every 3 h., could get none of the sym ptoms again except a weakness or lameness in hip, 28th. — Took fin dose of D. with no other effect than the old pain and soreness in hi( and pain running down back part of thigh. Stopped taking medicine and in 2 d. pain left hip and leg, and in 4 d. everything seemed to b in a normal condition.

b. April 1 2th, 1888. — After taking the third dose of E I had tb pain return in hip and leg ; it runs along course of great sciatic nem r. side, is neuralgic in character, increased by least pressure on DcrW It is a dull rather than a sharp pain ; by standing on toe of r. foot I gl some relief. It has been 10 d. since I took the last dose, and I yl have the pain in back part of r. leg, running from thigh to knee, can run my finger right along the course of the pain. Some incrcu in the quantity of the urine, I should say at least 30 per cent, mors light straw or lemon colour. This condition passed off, and dl quantity became normal in 24 h., with, after that, some reaction-^ should say about 30 per cent, less than the normal quantity. 1 cou] get no other symptoms from the drug. I stopped it about 10 d. t^ since then I have had a severe cold and have lost a large amount < sleep and rest, so that I am now in no condition to continue th proving. ( Ihid.)

1. W. C. Latimer, M.D., April 3rd, 1888, 745 a.m., took 3 g B. No symptoms. 4th. — 10 a.m., took 5 gr. Same result. 6tlL-

4 p.m., took 5 gr. Sharp neuralgic pains begin just to 1. of vetfl directly above ear, and seem to go directly down through head. Tbt come on suddenly and gradually die away ; "• it seems as though I bi been hit hard enough to cause sudden closure of the mouth." 9 pn took _5 gr. Pains renewed, came on three times during the foUowU h. Last time remained more or less marked for several d. [Ihid^

1. John L. Moffat, M.D., act. 35, weight 136; medial blonde; unmarried. Chronic catarrh} haemorrhoids; chr. otii media catarrhalis dextra. Subject to occasional attacks of indigestioi Pulse 74 — 80, soft, small. Respiration 12 to 15, apt to be sighing^ Urine in 24 h. about 68 f^, s. g. 1018 = 57 grm. solids. Noalbumc Crystals of oxalate of lime abundant. Two small yellow waxjfj Vibriones. Mucus. May 31st, 1888. — Took 10 doses (5 gr, of B from g.40 a.m. to 11 p.m. At about 10 p.m. slight pain in r. chest above nipple, which disappeared on taking a breath. June i. — E., throat has been red and felt cedematous more less to-day. (I may have caught cold from an open cor windi yesterday p.m., and by riding backward in an open car this p. Rarely have sore throat.) About 9 p.m. a feeling of a lump io r. throat, on swallowing. After sitting at work (9.30 p.m.) oci "spots " of slight pressive pain (>by straightening up) under st Took 5 gr. B nine times without effect. Dec. 20th— 24th, tool of C several times daily without effect. Jan. loth, i6ch, and 2i»i' 23rd, took D in like manner and with same results. Feb. 6— ^^

took 10 er. doses of £. 7th and 8th. — In p.in. constrictive pain while walking m anterior aspect of shins, lower third, < left, as if I were ■walking very hard and fast (which I was not). loth. — Morning stool of dark, muddy, greenish colour. This continued for 3 or 4 d., gradually changing to normal colour. {Hid.)

1. W. T. HoNAN (medical student). A was commenced Jan. ist. No symptoms. B, persevered in for a time, produced but little effect } I ami not very susceptible to the action of medicines. After taking C for several days noticed symptoms of great physical and mental languor. Indisposed to physical exertion. Inability to fix attention or to concentrate thoughts. Great tendency to lapse into a state of indifference. Preferred being alone and undisturbed. Things which were usually regarded with interest could now no longer entertain. With these ^symptoms, a dull heavy headache with sense of fulness, and isolated or transient stitches in temples or parietal regions. Not confined to any portion of head. This headache was noticed particularly about 5 p.ni., sometimes at 1 1 a.m. Mental faculties very sluggish. Ideas teemed to be generated slowly. When thinking deeply or trying to recall something forgotten there was a feeling as though a long process was being enacted to slowly grind out the idea. Got irritated at my own mental sluggishness. Memorv impaired for familiar names, facts, Sec. Muscular exhaustion, which, later on, became more pronounced. Knees felt as if they would give way under weight of body. Unable to walk fast} seemed to be making great exertion, but little speed. Epistaxis, apparently from posterior nares, with constant desire to expectorate bright red, but rather thin blood. This lasted about ^ h., not very profuse. (Never have had nose-bleed, except from a severe blow.) Dull aching pain in hypogastrium. Lost about four pounds in weight in about 3 weeks. Excess of urea. No albumen or casts. (For several years the prover has had a small nodule on the dorsum of the I. little finger, which has remained stationary, but since the time this drug has been taken it has diminished nearly one half. Others have noticed this. The great physical and mental depression necessitated a cessation of the proving.) {Jiid.)

2. Ira W. Denison, st. 23. Medical student. Nervous temperament. Previous health very good. While at home subject to frequent attacks of acute coryza ; in New York these attacks are very rare. Urine normal. Other organs also normal. Jan. 17th, 1888. — Took about 5 gr. of A at 10 a.m. This was followed almost immediately by sense of uneasiness in stomach with very slight nausea, and this was soon succeeded by a sense of weight and fulness in that organ. There was also a fulness in centre of forehead. 21st. — Commenced taking B this m. ; made a chemical examination of my urine this afternoon, it was perfectly normal. 23rd. — Finished B to-day ; still without symptoms. Another examination of urine failed to discover any changes. Took all of C without result. 31st. — Began taking D. Spent that e. out, and all the time was troubled with a sense of weakn« an all-gone sensation over abdomen } later in e. caught a severe t from driving from Brooklyn to New York in a closed carriage, fint *

I have had in four months. Feb. 1st. — All d. had t!i».« ««n.«a»

weakness over abdomen, with little appetite j tongue clean, but swollen, flabby and cracked in edges. Nose felt stuffy ; judged it to be due to the cold taken last night, and. — A feeling of weakness and faintncss, with occasional mild attacks of pain, over abdomen has been present most of the day. Great hoarseness without other indications of i cold ; but I think this to be due to the exposure on Friday m. 3rd.— Very hoarse all d. ; in early m. raised quite a lot of greenish mucus, came up easily in good-sized lumps. The tenderness in abdomen present at intervals. Finished D this m. 4th. — Hoarseness so bad that I can scarcely speak above a whisper, and so am taking other medicine for it, beginning to-day, thus compelling me to close my proving. (Have had a number of similar attacks of hoarseness ; the last, about two years ago, was very obstinate. This one was almost entirely relieved by a few doses of phos. 3, so much so that there is only a vcfjr slight huskiness, scarcely noticeable, at night. With that slight exception

1 have now — 8th — entirely returned to the normal condition.) (liiJ.)

1. Miss M. H. Broichaus, 25, medical student (senior year). Examinations reveal normal condition of chest, pelvic, urinary^ rcspifitory, and sensory organs; pulse 70 ; symptoms appeared or were more marked in the intervals between the bottles. Took 5 to 1 o gr. every

2 h. ; began proving Nov. 20th, 1888. Various symptoms appeared while and after taking A, which also occurred later in the proving and are consequently not noted. B made urine slightly turbid (urates), 8. g. 1020 — 1037, acid, quantity normal. While taking C there suddenly came on a loose cough, painless indoors, but with pain when coughing in open air. Menses appeared ; no change except in colour, which was very pale during first half of period. Pulse irregular. The catarrh extended to the nasal mucous membrane j a thick, tough, yellowish mucus was detached from the posterior nares every m. after long-continued hawking. Under D all the symptoms with the foregoing bottles remained the same. Pulse 80 — 100, irregular in force and frequency. Contractions of heart were incomplete ; vertigo whea moving head after having held it steady for a short time after reading. Under E symptoms continued as with D, only a trifle increased, but the sp. gr. of the urine is 1020 — 1025. Borders of gums become dark bluish gray. Stopped proving Jan. 7th, 1889 ; all the symptonu disappeared by 15th, except those of pulse, heart, and gums, which still exist (Jan. 25th), but are gradually diminishing. {Hid.)