Sulphur

Volume IV — Main text

SULPHUR.

ominon brimstone. (The "flowers of sulphur" carefully washed with distilled water, and dried in the open air.)

f I. Pravings. — 1. Hahnemann, yWtf/. yi/ir^. Para, vol. iv of original, vol. ii of translation. Contains 755 symptoms from self, and 60 from his son Friedrich and a few authors.

1. Ibid., Chronic Diseases, part v of original, vol. of translation. Contains 1969 symptoms, most of the additions being from Hahnemann himself.

2. (No information.) Dazed head, want of steadfastness of joints, disinclination to speak and itembling in limbs. Giddy state of head prevents acute and clear thinking. He is not always master ol his thoughts and words, expresses himself differently or with different words to what he wished. On rising m., cheerfitl, clear, resolute, but at 9 a.tn. the dazedness returns and is much increased by serious thought. Undulation and confusion of head, c. Diarrhoea with rumbling in bowels. Even in bed has strong call to stool, then some diarrhoea. Frequent, difficult, painful and scanty urination. Constant pressure to stool and urine, and immediately aiter

^Ki

urinating a few drops ot blood and a violent stitch in urethra, with anxiety and dis cumtort. Immediately after rising scrapy throat, then several bloody rxpectorationiJ an<[ all p.m. great hoarseness», to which later headache is added, which is very acutr,ell A kind of dislocative pain in arms, as after a debauch the d. before, especially when lifting up things. (Gross, Archiv, xix, 3, 186.)

1. (From breathing-in dust of S. when preparing triturations with Mure's machine.) Stiffness of nape, and cracking of cervical vertebn on bending back head, after 6 h., lasting 3 d. Bruised pain in I. pectoralis muscle, and drawing or tearing pains in 1. shoulder and muscles of upper arm, especially when moving, breathing, or even when touched (after 24 h. for 4 d.). Much tinnitus aurium, and like humming or buzzing in head, several d. Sensitiveness of eyes and like burning in them. Lachrymation of eyes in air and much eye-gum, m., several d. Uncommon heaviness and weariness in legs, several d. Coldness of feet, especially in bed, e., several d. Swollen feeling of fingers, after 2 d., for several d. Sudden appearance of a bluish-red spot on the inner aspect of I. index, as though from extravasated blood, without pain J after 4 d., went ofF after 3 d. Violent shootings in corns, in bed, e., several e. Frequent starlings up in sleep, several n. (Hencice, A. h. Z., Iv, 14.)

2. a. After 1 dr. tinct. most violent itching all over body, especially on forearms and legs, in bed, e. After scratching till the linger was sore and livid he had to use a hard brush.

b. After ^j flor. sul., vesicular erysipelas over whole r. leg, pre ceded by fever: The leg is swollen, hot, bright red, painful, in several parts there are larger and smaller blisters containing yellow serum, such as is caused by cantharidcs. After the blisters burst some of the spots become covered with yellowish-brown thin crusts, others become flat ulcers which continue to suppurate for a considerable time without pain, and gradually heal up, long after the inflammation has gone. (Knorre, a. h. Z., vi, 37.) I

1. (No information.) Great weakness in chest, which troubles him particularly^^

when he goes to bed at n., so that he cannot lie long in one place, and is glad when m. comes. Great rci>tlcs<ines$ and ebullition of blood. (Helbig, HerailiJtj, , 64.)

1. Violent burning in whole body, with anxiety. (HoM., IbiJ.) ^k

2. Pimples under glans penis, which burst and suppurate. (P., IhU.) ^U

3. VocT, medical student, took, Jan. 25th, in 24 h. 8 teaspoonfuls of a mixture of 3iss flor. sul. and 5VJ white sugar. (On the 23rd he was bled to 787. grms.). — 27th, 4 teaspoonfuls. — 28th, 8 teaspoonfuls. — Was bled again on 29th to 897 grms. He experienced no symptoms whatever. Whilst taking the medicine the urea and uric acid in the urine were increased slightly. The blood drawn before taking the Sul. showed in 1000 parts :

Solid matters of the defibrinated blood . 209*800

„ „ serum . . . 9575°

„ „ albumen of serum 84-314

Extractive matters and salts of ditto . . 11*436

Fat of ditto ...... 0-327

Fibrin ''578

Blood-corpuscles 112*472

J 73

Coagulum

Serum .... Sp. gr. of defibrinated blood „ of serum Coagulation occurred in the usual time.

482-142

. 5i7-«58 1-0520 1-0285 After 4 h. the serum was

poured off. The coagulum was reddened in a few m., excepting some i&cUnotic spots, some of which were of considerable size.

The blood drawn after taking the Sul. for several d. showed in 1000 parts :

Solid matters of the defibrinated blood . 201*000

„ „ serum . . 91*800

„ ,, albumen of scrum . 81*296

Extractive matters and salts of ditto . . 10*504

Fat of serum ...... 0*326

P'ibrin ....... I '447

Blood-corpuscles '07753

Coagulum 43' 372

Serum ....... 568*628

Sp. gr. of the defibrinated blood . . 1*0517

„ „ serum 0*0260

The separated serum was slightly red and turbid^ but became clearer. After 4 h. it was poured on the coagulum, which became l*right red on exposure to air, with many melanotic spots, but not so miny as in the first drawn blood. (Bocker, Beitr, z. Heilk,., ii, 388.)

1. Dr. Bocker took, June 26th, 6, 8, 10.20 and 1 1.20 a.m., 2.40, 4-I4, 5.14 and 11 p.m.,0'5grms. fl. sul. No symptoms, — 26th, 6 a.m., O-Jgrm., 9, 10, II a.m., 3, 4, 4.40, II, II. J8, 12 p.m., 07 grm. Much hawking. Slight cough with mucous expectoration, m., some- '"ncsfell as if he had phlegm on chest, soon afterwards coughed, and the ■"tathing became freer. All d. coughed up mucus, but less p.m. than Oi. II p.m., a soft stool. — 27th, 3.48, 5, 6, 6.55, 11 p.m., 07 grm. Coughed up a little mucus, m. At g.27 normal stool, at 11 p.m. a •oft Btool. — 28th. Called out at n. 11 p.m., 08 grm. No symptoms.— 29th, 8, 10, 11.35 a.m., 07 grm. 3.45, 11 p.m., 075 grm. 9.5 a.m., thin pappy stool preceded by flatus with odour of sulphuretted hydrogen, g.35 a.m., sneezing and mucus in nose. AH d, expectofiited a little phlegm. — 30th, 6.55, 10.15, o? E''"^- 4-> 5» IJ»0'8 grm. All d. expectoration of thin mucus. 5 p.m., rumbling in abdomen. 7 p.m., a thin scanty stool, — July ist, 6.45, 08 grm. 10.20, 11, 12 a.m., 2.45, 3.30, 4.15, 5, II p.m., i grm. On picking nose, slight epistaxis. After rising and walking frequent rumbling and gurgling in abdomen. Then urging to stool, which was normal. Occasional cough, nose moist, which went off after breakfast. After dinner transient pinching in belly. 11 p.m., a stool rather looser than normal. — 2nd, 5 a.m., urging to stool and some pain in abdomen which woke him up. After passage of foetid flatus the urging went oflF, but recurred at 7 and 8 a.m. At 8 a.m. a loose stool. After breakfast nausea for a short time. 3.29 p.m., foetid flatus, soon after that transient pain deep in pelvis which recurred at 3.40 p.m., but which went o?i after

copious pappy body, and was quite well.* {Ihid., 398.)

1 1. V. Arigler, set. 22, robust, always healthy ; had itch when 16. From Oct. 29th, 1846, to Jan. 6ch, 1847, took every m. as much as would cover point of knife. On Oct. 31$! had feeling of weight in stomach, which continued all next d., and recurred following c. On 31st 3 fluid stools. On Nov. ist., e., great weariness in legs. From 3rd to 6th motions insufficient and very hard, and till I2th altogether absent, urine also being scanty. On iiih a catarrh came on (f medicinal), lasting till 13th, accompanied by diarrhoea with griping and at last tenesmus, for which — on 15th — he took Dover's powder. On i6th and 17th felt quite well. On 18th and 19th frequent urination, even at n. (a thing unknown to him). On 19th and 20th profuse general sweats, on 21 st and 5 following d. same on hands and feet (especially latter), in d. only. From 27th to 29th these went off gradually, and stools became more copious. On 30th headache, with burning and redness of eyes. From Dec. 2nd to loth, no symptoms. On nth, and to end of proving, had every n., when warm in bed, a disagreeable itching from hips to toes, especially bad in hams, removable only by rubbing, which caused very pleasant feeling. On parts so rubbed occurred small pimples, discharging fluid from their apices, whereupon itching ceased. In daytime scars only were visible. On 24th an itch-like eruption appeared in bend of elbows and on wrists. It did not itch, and disappeared next d. On 30th and 6 d. after, m. and e., violent cough with copious mucous expectoration. (Wurmb's provings, Z//«^A. d. Vtr. ham. A. IViens, 1857.)

1. a. Arnetk. From Sooth and 400th dils., taken from Oct. nth — 24ch, experienced no eflccts, save that sleep seemed rather less refreshing. Five dr, of 31st were then taken on 27th and 30thj Nov. 5th and 15th. During this time had periodically recurring but not very severe pains in temples, followed by acute screwing pains there. Nov. I St. — Violent pains in i. eye, as if rubbed against spiculx of glass and drawn in at pupil, with involuntary winking, followed by burning and lachrymation ; attack lasting 2 m. On 3rd and 6th bleeding after easy motion, and raw pain at 1. commissure of mouth, lasting till 9th. On 15th frequent shoots in splenic region, and frequently recurring confusion of head. On 22nd, 23rd, 24th, 25th, and 28th, took 5 dr. of 13th. On 22nd had severe cutting in r. eye, and 1. commissure of mouth was again painful. On 24th painful contraction in last fingers of r. hand. These were transient, but while taking 13th had also persistently light sleep ; constant call to micturate, with feeling of warmth in urethra while doing so ; painful confusion of head ; and great excitement after drinking tea, though accustomed to it.

2. Ten gr. of 3rd cent., in solution, on Jan. loth, 14th, 1 7th, 23rd,

•

«

• fioCKER also relates a. number of experiments with S. on patients, but thctc are unmitcd for this work. As a genera) re«ul(, he found in all that the solid constituents of the urine and blood were 15 a rule diminished while taking the medicine, and that in those cases which he examined for the purpose, the frequency of the pulse wa^ dimini&bed and the excretion of carbonic acid by the lungs was increased. (I^J., 418.)

»75

26th, caused, on lOth, calm sleeplessness for ^ h. at a time ; on 'tth and I2lh, towards n., eruption of 10 — 12 small bright red pimples on 1. forearm, which itched much when touched, easily burst, fd let out some thickish fluid ; on 12th, previous to good stool, violent itting extending far up rectum; on n. of 14th sleep unrefreshing, disturbed by vivid dreams of ordinary occupations ; on 15th soreness of c-omraissure of mouth, violent tearing contractive pains in r. hand; J7th — igth frequent urination, and on n. of 17th vivid dreams of **^g-past events. After a month took 4 doses of same dry on tongue 4 d. from March 6th to 17th. On 7th commissure again sore, on *■ *^ raw pain in anus, and after the 4 doses a peculiar roaring in ears *^<i subjective odour as of a flower.

c. Ten gr. of crude substance taken on April 25th and 28th, and

gr. on 30th, caused on 26th 4 loose motions ; on this and following

increased urine, and great appetite which could not be indulged — a

Xlc food causing troublesome distension; on 30th, violent digging

ons in a r. healthy molar, diminished by strong pressure, unaffected

^i'" cold or heat. At beginning of May prover had an attack of inter-

V*^ittent fever (rigor with thirst, long-continued heat without thirst,

^Vit with great rush of heat to head), lasting six weeks, leaving him

^cry weak, and with (at beginning of September) caries in 5 sound

^^eth. Whether this (unique) occurrence can be traced to the S. must

*'emain doubtful. {Ibid.)

1. a. Gar AY. Jan. 22nd, noon, took 10 gr. of 6x trit. Soon after, loose foetid stool, followed by annoying, straining, ulcerative pain in anus on touching it, and long-lasting feeling as if diarrhoea would recur ; slight 1. supra-orbital pain, and (15 m.) slight and transient vertigo. On going to bed, rigor and aching in r. vertex, lasting till sleep came, and recurring for an h. on waking. On 23rd, took 20 gr. All d. tickling at back of pharynx, causing tussiculation ; at n., on micturating, violent shock through urethra to above pubes ; rigor in bed. 24th. — All d. scraping in throatj and cough with expectoration. At noon, aching in I. forehead, and drawing pain in upper teeth, first of 1. then of r. side, with sense of swelling and soreness of gums of former; also short rigors, frequently recurring (especially on movement or empty swallowing), with blue nails, pale face, giddy and heavy head, and sense as if humeri were broken ; the cold is not removable by heat of fire, and there is sense of draught across abdomen above navel. After coffee, burning in r. cheek and ear, rest of body remaining chilly. In afternoon great sleepiness ; at times bruised pain in outer 1. tibia, and slight griping in bowels. On going to bed nervous excitement, with recurrence of symptoms of 1. upper gum and teeth. Painful chap in middle of upper lip, and troublesome itching all over body save inside of limbs, occurred, and lasted several d. On 29th, feeling well, took at 2 p.m. 40 gr. of 8x trit. Soon after former pains in 1. forehead and Jaw, with slight griping in bowels, horripilation in both arms, and paralytic pain in 1. leg. At to p.m. sudden urging to stool, continuing after passing lump of hard fxces, and merging into increasing and iung-lasting gripings in r. abdomen, with much flatus and itching at anus ; compressive pain in glans penis, angle of 1. maxilla, and 1. and

r. auricle near meatus. On 30th and 31st, m,, the frontal aching (r. also) and shoots in urethra ; at noon, the rigor (Hrst outside of arms, then down back to sacrum, then across abdomen), — it was lessened by warmth, increased by movement, and accompanied by weariness, pale and suffering countenance, and pains as if broken in upper arms, thighs, and legs, shooting in outside of feet. Appetite not impaired. At 3 violent tearing in r. knee and ankle, boring squeezing pain in r. forearm. At 11.30, while sitting, acute shoot in bend of first r. then 1. knee, with horripilation at side of chest. Feb. 1st, e., very painful shoots along 1. scapula, frequently recurring, and long^lasting. On 2nd took 10 gr. of 8x. Immediately after, rigor. On 3rd, in bed at n., attacks in 1. shoulder of shooting throbbing pain so severe as to make him cry out. On Feb. 6th, at noon, took 20 gr. of 8x. During d., headache only j at n. and next m. griping in bowels and frequent urination. During 7th annoying paralytic feeling on outside off. leg and forearm j at noon, violent drawing along outer side of r. forearm and leg. Hands had for days past felt unusually cold, and lips as if covered with salt. On gth, much straining at stool, with aching in small of back. On i6th set in itching all over body, desquamation of skin of face, and humid eruption on vertex — small grain-like pustules filled with pus, and drying up into honey-like scabs ("achor granulatus"). These continued till 20thj when he had also roughness of throat and nervous sensation in it, compelling frequent hawking ; shooting through pupil deep into 1. eye on attempting to read (lasting several d.), and in c. troublesome heat in eye ; painful pimple on r. car, lasting 4 d. ; and violent itching in glans penis and mouth of urethra. On 26th several diarrhceic stools with burning in anus preceded by gripes ; much mucus in throat. (These symptoms aggravated by beer). In e., great burning in anus and urethra, with frequent urging to micturition, and burning at urethral orifice during it. In bed every place appears too hard for his head.

h. March 3rd, at 10 p.m., took 31] of pure substance in water. At night heat all over body, especially in palms, continued erections, with vivid, not lascivious, dreams ; itching in bend of elbows, scratching which causes moisture to exude. On 4th, some headache ; at n. loud borborygmus, followed by copious, pappy, yellowish-green, very foetid motion. On 7th took '^ss without eft'cct. On loth, took ^, with recurrence of symptoms of 4th ; after stool he felt quite well. After three weeks took another ounce, which caused legs and fingers to go readily to sleep on pressure j painful twitchings of 1. peroneus longus, lasting for weeks, and hindering walking ; for some time nightly itching all over in bed; his food cannot be sufficiently salted. On April 5thj intolerable burning along urethra, as from pepper, immediately relieved by a dr. of cantharis fj>. On gth at n. horrible dreams with great palpitation ; on waking, sometimes rigor, sometimes heat and fear of robbers On i6th took ^'j in water. In e. jerking cutting in r. eye, spreading to temple, lasting several h., and renewable by touching r. side of point of nose. In bed, slight shivering, then general heat, then profuse sweat with odour of drug. On 17th, early, four soft stools. Therewith heat and salivation, afterwards thirst ; before.

during, and after, inclination to vomit and burning at anus. There

n^as burning also in 1. ala nasi, lasting but a few m., but frequently

recurring ; occasional shoots in urethra } dry feeling and tensive pain

on 1. side of palate, extending to r. and lasting 2 d. Thenceforward

quite well.

c. Daughter, act. 7^. Doses of gr. v and xx of 6x both caused violent pains in umbilical region. {Ibid.)

X4. F. GoTTWALD, aet. 37. Healthy save for occasional mild

gouty symptoms. On June 9th took 5J of i,. Soon after, dryness in

^mouth and throat, and aching in 1. eye } after dinner deafness of 1. ear.

^n Sth, m., rheumatic pains in nucha ; griping, relieved by a liquid

"■Jcfc^ion ; after dinner aching and shooting in praecordia ; in e. aching

Sf ' « eye, twitching of lids, and violent tensive pain in 1. tendo Achillis.

.*^is subsided during n., but on 9th, another 5J being taken, it returned

^^1:1 increased intensity, was especially bad at rest, and resembled gouty

P'^-^^s of years gone by. Had also great sleepiness after dinner ; frontal

. "^ing } and sensation as if hair on vertex were pulled, though he had

°*^^ teen bald there. On loth was weary and feverish ; had itching

^ Virethral orifice, straining at stool, and tension of skin of face. On

. ^ '^h, in m., much thirst ; dryness and warmth in throat ; itching of

' ^^7^' aggravated and extending on being rubbed. At noon, tearing

^^■i ns in iTtibia. P.m., burning in anus and tenesmus. In e., dryness

^^^ heat of skin. At n. perspiration, with relief of skin. On 12th took

*^j of 3x. Same symptoms of mouth and throat, of anus, and of stools,

^^d on 2 d. stiffness and tearing in wrists and ankles when at rest, going

^ff immediately on motion. On 2nd n., painful aching in small of

uack and restless sleep. On 14th, after another scruple, same dryness

of throat, and liquid, griping stools ; frequent sneezing and coughing;

shivering and weariness after dinner ; involuntary stool when sneezing

or laughing ; at n. tenesmus and swollen piles, unknown for nine

years. (Ibid.)

1. Hausmakn prepared a series of ^ triturations, and took large doses of them — gr. xx — Ixx^ descending regularly from the 1 6th to the 1st in 9 d. The most marked and recurrent symptom throughout was a drawing pain, generally on the dorsal aspect of the limbs near the joints, penetrating somewhat in, once described as going like a stream of air over the part, and causing a feeling of paralysis, once (in the tibia) accompanied by sense as of cool breath on small of back. He also had, after the 14th, attacks of aching on r. base of thorax behind, proceeding from inside, penetrating deeply and lasting some time, recurring periodically for 3 d., uninfluenced by movement or posture J after 13th — 10th, great sleepiness pest prandiurrty and on waking confusion of head till e., diminished by walking in open air ; after 6th and lower trits., diarrhoeic yet formed stools, mixed with much mucus. From 2nd and 1st tenesmus was added. After finally taking gr. xvij of ist on April loth he had much flatus in transverse colon ; great confusion of head, worse when walking in open air ; later, contractive pressure in abdomen, loose stool with great anxietas, followed by sweat all over body, especially on forehead, which relieved head ; on rising from stooping, vertigo and weight in head ; on waking before VOL. IV. 12

ina-

midnight, pressure in 1. frontal eminence. From I4ih to igth had inflammation of point of nose, ending in an internal scab; a herpes circinatus on finger became on one d. more swollen, red, and shining, and on next r. cheek was covered with small red painless spots, lasting only 24 h. From 21st to 27th drawing pain only continued. On aSth, in lower front of r. chest dull stitches from within outwards like blows, ending within thorax, excited by deep breathing, sneezing, Sec From 2gth to May 5th a whitlow on volar surface of point of r. thumb, on ulnar side, finally bursting and discharging. [Ibid,)

1. a. Wenzel Huber tookgr. x of 6x daily from March 27th to April 6th without effect. From April 2nd to 7th took daily gr. x of 5x. On 5th had drawing tearing pains in r. scapula, lasting 3 d., and increased by every movement, also reddened tonsils and painful deglutition for 2 d. From 7th to I2th, gr. x of 4X daily. On 8th, soon after taking medicine, bruised pain in small of back, annoying him all d. From 10th to 12th hoarseness and tightness of chest; on I tth also disgust and inclination to vomit all d. ; on 12th ill-humour, and recurrence of pain in back (increased by every motion). From 13th to 18th daily gr. x of 4X. On 16th, all d. deep in centre of thorax a sore place of size of crown-piece, pain increased by movement and inspiration. From 17th to 19th, r. nipple swollen, and painful to touch and on deep breathing ; on i8lh roughness in throat and inclination to cough all d. From 19th to 30th took daily gr. x of ij. Eve m. till 25th slight aching in forehead, but no other symptoms.

b. On Oct. 1 6th renewed proving with 50 gr. of 6x. In 30 m. palpitation for 2 m., with anxiety as if about to faint. On 17th took 100 gr. After i h. aching pain in forehead and confusion of head, as from too much alcohol ; fulness and weariness after dinner, relieved by walking in open air : same dose next d. caused repetition of symptoms in stronger degree. On 19th took 100 gr. of 5x, and repeated it on 20th, 22nd, and 23rd. Nothing save slight gastric disturbance^ and a pimple on upper lip occurred till the 23rd, when (and also oj^H 24th) he had frontal aching in m., and later burning pains in occipu^^ for some h. On 24th took 100 gr. of 4X. In 30 m. heat in occiput, and dull aching over whole head for 3 h. After dinner confusion of head, going ofF in open air ; on returning to warm room heat in occiput ; no sleep from 1 2 to 3, and great confusion on waking. Took another dose : head symptoms returned, but were slighter ; restless sleep after midnight. Next d. r. nostril sensitive and reddish. On 27th, after same dose, occipital pain and heat recurred, and were more persistent j and inflammation had set in in the nose, ending in desquamation on the 31st. Two stools, each followed by a few drops of red blood. All d. fulness in hypogastrium ; also tension in 1. great toe and its metatarsal bone, lasting 2 d. longer. On 28th, after same dose, frequent sudden vertigo, especially when near a declivity ; worse after beer. On 29th, occiput again affected as before, in sudden attacks. After dinner, when walking, great weariness and aching in stomach ; weight and fulness in hypogastrium, with feeling as if something heavy pressed on bladder. On 30th took 100 gr. of 3X. Blood after morning stool : same head and stomach symptoms, but lighter

■1st, repeated dose. With the hypogastric pressure frequent passage

of small quantities of clear urine. On 2nd, another dose ; same head

and bladder symptoms, with sense of obstruction in endeavouring to

roicturate. On 3rd, same dose ; same symptoms, with some griping

and looseness, and pressive pain on 1. eye. On 4th, pressive headache

over eyebrows all d., somewhat severe ; itching on scrotum and thighs,

"with sweat, which continued — involving also prepuce — to end of

proving. On the 5th took 100 gr. of 2x, and repeated the dose on the

7th, 13th, 14th, 15th, 17th, 20th, and 2 1 St. The toe symptoms

recurred, as also those of head and stomach. Slight abrasions on hand

caused inflammation and suppuration, and three boils and an itching

pustule appeared. On 25th, 26th, 27th, and 29th he took 100 gr.

of 1,. Besides the usual symptoms, there occurred pressure and

asthmatic feeling in chest, with disturbed sleep and sour nocturnal

perspirations. On 28th there were frequent sudden tearings in fingers

of both hands and dorsa of both feet, and on 29th and 30th pain in

ankles, so that at length he could hardly stand. " The confusion of

the head, the aching in the occiput, the feeling of fulness in the stomach

and hypogastrium, and the pressure on the bladder, lasted some d.

longer, but the symptoms that lasted longest were the perspiration and

itching on the scrotum and prepuce."

c. On Jan. 8th H. began proving of tinct. with 100 dr. in water, which he repeated next d. and on the 10th. The symptoms of head and abdomen returned, and the feeling in the bladder extended to the rectum and anus; sleep was very dreamful. On iith and 12th took twice 200 dr. Same symptoms ; and on e. of i ith toothache in sound teeth for an h. On 15th took 400 dr. j same symptoms, with some eructation like heartburn, and irritated cross temper. Two doses of 200 dr. each on 16th elicited nothing new save constriction of chest, and the same has to be said of two of 400 each on 17th. On discontinuing medicine diarrhoea came on,withgripings below navel, and burning and tenesmus at anus, lasting 4 d.

d. From 23rd to 26th he several times rubbed in the tinct. on the thighs and arms. Desquamation and a papular eruption occurred on the seat of friction, and the head and stomach symptoms occurred to a slight degree. {Hi J.)

1. Madame Huber took the trits. with her husband in his first series of experiments. She experienced nothing from 6th and 5th. While taking 4th and 3rd began to dream anxiously. On April i6th catamenia occurred, at regular time, but, while usually lasting 3 d. only and being scanty, they now flowed profusely for six ; the blood was black, clotted, and as sticky as glue. While taking 2nd the anxious dreams recurred, and were very vivid, twice leading to micturition in sleep. On 23rd had contractive pains in uterine region towards pudenda, resembling sensation preceding catamenial flux, lasting from m. till n., and leaving bearing down next d. On 26th there was violent contractive pain, and p.m. the catamenia returned, this time occurring normally, but leaving her weak and irritable. From 24th to May loth red burning spots came and went on palm of r. hand. {liiJ.)

2. Man, xt. 47, robust. From 15th to 23rd Oct. took 20 dr. of

i8o

tinct. daily, on 24th 30 dr. Dull pain in head and dreamful sleep were noticed, but save these the symptoms produced were entirely seated in the tongue. Dull pain in its root occurred on 20th, when it looked somewhat red and swollen ; this recurred with increasing severi cy every evening till the 24th, speech being obstructed, and one of tlie papillx felt enlarged. He left off the medicine from 25th to 30thj a.n<i symptoms disappeared ; but on talcing daily doses of 30 dr. from 3 K st to 7th Nov. pain returned and increased, with swelling as before, so that he discontinued the proving. In 3 d. the tongue was again quite normal. {Ibid.)

1. a. WiLHELM Ht7fiER began with the high dils. June bthy 1846, at 7 p.m., he took 5 dr. of the loist. In 2 h., when in bed, violent rush of blood to head, all arteries of which were felt beatings, with heaviness and confusion in it, roaring in both ears, and dul/ drawing throbbing pain deep in r. forehead, of varying violence ; whole attack lasted ^ h., ai.d he slept well afterwards. Next m. woke at 5 (unusual) with throbbing ache in r. occiput and pain in 1. sacrum; former went off in i h., latter after getting up. On stretching om legs in bed very painful cramp in r. calf^ At 8 a.m. every step upstairs caused shooting wrenching pain in metatarsal bone of r. great toe; same pain felt p.m. while walking, but then beneath 1. outer ankle. 6 p.m., took 10 dr. In 2 h., at every step cramp-like pain in 1. calf and pains in corns of 1. foot. 8th. — No med. and no symptoms. 9th. —Took 15 dr. at 6 p.m. After 4 h., in bed, sense as of sand under eyelids, and of heat over surface, with tendency to perspire, and slight threatening of headache in I. forehead. On going to sleep, uncomfortable dreams of murders, from which he woke at 4 feeling very tired, and with tensive aching in 1. sacrum. loth. — Took 20 dr. at 3 p.m. After 4 h., sudden, oft-recurring, dull drawing pain in 1. forehead, alternating with similar pain on r. side ; when walking, frequent wrenching pain in I. inner ankle. At n. in bed, drawing pain penetrating deep into bones — as when ice is held long in hand — now in metacarpal bone of r. index, now in r. knee, lasting a few seconds only. N. undisturbed, nth. — On waking in m. transient colic-like pains below umbilicus, as from flatus ; wrenching pain in 1. knee while walking. 8, pressive pain on vertex. 10, shooting as if in I. pleura. 7 p.m., when standing, several throbbing shoots from anus through rectum into r. hip. 8, took 25 dr. Soon after fine stitches in 1. great toe. At n. great flow of water from mouth. 12th. — Frequent fine burning stitches in skin of 1. upper eyelid, as from sparks ; cramp-like painful drawing (while at rest) from inner to outer r. ankle. 13th. — Took 30 dr. in m. About noon, both at rest and when moving, frequently recurring, very troublesome, cramp-like drawing in muscles of ant. int. surface of r. thigh, followed by sudden tensive aching in I. occiput. 14th. — M., while walking, tensive aching in whole of r. calf, as if it were too short and were made of wood, lasting ^ h., and then giving place to brief tensive aching in I. occiput. About noon took 30 dr., after which he had sudden, oft-recurring, dull drawing, deep in 1. forehead. During following 8 d. he ceased taking medicine, and felt perfectly well. On 23rd took 15 dr. of 102nd dil. No symptoms.

fSi

14th.— In m. 24 dr. During forenoon frequent recurrence of a dull, </niwing, penetrative pain, now in r. hip, now in 1. forehead or J. oocipvt. 4 p.m., unusually hard stool. 5, dull digging pain in 1. forebad, with confusion of whole head and forgetfulness ; both eyes dim, kilt very jcnsitivc to bright daylight. 25th. — M., 25 dr. Frequent piinfui drawing, a.m., through metacarpal bone of I. index. Itching siiooting in outer canthus of r. eye, and sense as of fine sparks in skin at I. upper lid. 26th. — M., 25 dr. Towards noon, dull, drawing, frontal headache, after a few m. alternating with similar pain in r. wrist. Between 4 and 5 p.m. boring, shooting pain, now in r. groin, now in spermatic cord extending to testicles, now within inguinal ring ; followed by sharp cutting pain in r. great toe. 7 to 8 p.m., when talicing, cramp-pains in 1. calf and wrenching pain in 1. ankle. 27th. — M., 30 dr. After dinner several fine stitches in r, concha, and cramplike drawing below r. mastoid process; soon afterwards great flow of talivi and sudden softly digging pain in r. parotid ; followed by sharp ttitches, now in 1. great toe, now in 1. thumb, and the spark sensation inL upper lid. 28th. — M., on waking, tensive aching in 1. sacrum, ttlending to near 1, great trochanter, going off on getting up. About 9i.in. burning on spot about a hand's breadth in extent in skin of I. elbow, extending gradually over extensor side of joint, and lasting upwittiB of 10 m. About noon nausea coming up from stomach, with hnt efface. P.m., confusion of head with rushing out at 1. ear, and dull drawing pain in 1. forehead, soon alternating with penetrative cramp- 'ikepjin in I. knee or wrist, or with stitches on root of nail of r. great tKi at same time, while walking, frequent cramp like pain in 1. calf. £. in bed, several very sharp shoots (as from a blunt nail) in rapid succcttion at same spot of r. great toe. 29th. — M., after rising, wrenching pain on walking in I. hip. An h. after taking 40 dr. confusion of |>^ with dull aching in forehead, and great dimness of vision on reading a though cornea had lost its transparency, — at same time feeling of dryness as from fine sand between eyelids. P.m. frequent alternation of frontal headache with pain in joints described the d. previous. JWh, — E. in bed, on stretching out legs, very painful cramp in 1. calf, *Bing him to cry out ; it lasted 15 to 20 seconds. This cramp continued to annoy him long after completing proving.

t. H. now proved the first six decimal trits. Aug. 4th, about °l.ni., took 25 gr. of 6th. it a.m., frequent attacks of dull head- **!>«, deep in 1. forehead, at rest and when moving, sometimes increasing to drawing throbbing, 2 p.m., dizzy confusion of head, heat and fcdness of face, and sensible throbbing of arteries of head and neck ('luting over \ h.}. From 4 p.m. constant pain in corns as if boot PtctKd upon them, and frequent drawing penetrative pain, with stiffly now in 1. great toe-joints, now in and about r. ankle (in rest and ■lotion). N. in bed rush of blood to head, with heat and confusion 'nit^ noise of water boiling out at both ears, and frequent painful dnwing in r. ear. N. very restless. After midnight, cramp-like. Penetrative pain spreading from metatarsal bones to sole and instep of L foot, which, after lasting a short time, was succeeded by precisely ■ MitiUr pain In r, foot. In m. he felt tired and unrefreshed. sth. — •

lB2

At 7 a.m., 2S gr. A.m., some violent shoots, now in 1., now in r. great toe. P.m., drawing pains (at rest), now over 1. inner ankle, now in shoulder-joints, now in r. or 1. wrist, often alternating with sharp shoots in rectum. In c. sudden shooting itching in fossa navicularis. 6th. — About 8 a.m. took s gr. of 5th. In an h. painful drawing in proximate joint of great toe, at rest ; afterwards, when moving, cramplike penetrating pain, at one time in inner ankle, then in lower calf, in knee, and in groin. P.m., a precisely similar pain, first in r. mentarsus, then in elbow, wrist, and metacarpus of same side, always lasting a few m. whether at rest or in motion. 7th. — At 7 a.m., 10 er, In an h. cramp-like drawing pain (in rest or motion) in r, inner anicic, alternating with dull drawing pain in r. forehead. Thereafter burning in skin of whole extensor side of r. upper arm, which lasted above ih., and after scratching left raw pain. P.m., burning shooting beneath I. lids, as if sand had got into eye. On moving, cramp-like tensive pain, now in posterior muscles of 1. thigh, now in 1. calf, now in other muscles of extremities. lo-ii p.m., in bed, cramp-like drawing pain, penetrating r. knee outwards, and sometimes alternating with precisely similar but slighter pain in 1. knee, — therewith much offensive flatus repeatedly forming and being discharged. About 3 a.m. very severe cutting pain darting like lightning from r, deltoid to middle of upp«f arm. 8th. — M., took 5 gr. of 4th. After rising from bed, itching on several parts of skin ofl. hand ; after scratching red spots arise, 0" which several closely packed papules appear, lasting several d., a^^ itching periodically. Three h. after dose, wrenching pain in 1. h'p (walkmg and standing) and shooting here and there in skin. P.tBi frequently the above-described pains in joints of extremities (like tho*' experienced by arthritic patients on a change of weather — weather n^* very fine), alternating with cramp-pains in their muscles, former mos*at rest, latter when moving. At n. anxious dreams of danger frc**^ fireor water. 9th. — In m. on awaking feeling of sand in eyes, w** raw pain on rubbing them. 10 gr. were taken. During d. freque^^ cramp-like tensive pains in muscles of both mastoid processes. At '

restless sleep and frequent waking. lOth. — In m. 5 gr. of 3rd. A.r*^ !l loss of appetite, vertigo, confusion of head, dimness of vision, const» _ sweating, and frequent itching in I. auditory meatus, iith. — I^" 10 gr. In -i h. (at rest) dull drawing headache in 1. forehead wi similar pain, now in I. knee, now in I. outer ankle, now in 1. wri --^ ^ 12th. — M., 15 gr. In i h. (in bed) aching tension in 1. sacrum and h^- _j then sudden sharp cutting pain through r. knee forwards, alternatii after a few m. with similar pain in 1. elbow. After getting up pain back went off, but there occurred feeling of roughness within throz hoarse deep voice, and constant irritation to dry cough. Usual stool was scanty ; first part hard, causing sore shooting pain in pa ing, second part soft like birdlime. All a.m. weakness and dimness eyes, and frequent dry tussiculation. About noon some sharp shoe in urethra. P.m., while driving, aching in whole I. head; afterward while at rest, brief shooting cutting pain above ant. sup. spinous pr cess of r. ilium, followed by cramp-like pains in flexor muscles of :r arm. At n. in bed drawing in r. upper row of teeth, and, soi

^%ut later, distension of abdomen, griping, and frequent emissions of nsive flatus. 13th, — Wrenching pain (while walking) in 1. sacral gion and hip, and some shoots in I. sole and 1. testicle. ]4th. — M., ■ -^r~^ bed, sudden, sharp, cutting pain from behind forwards in 1. great ^^ — >e. P.m., some shoots in 1. tendo Achillis. At n., in bed, for some ^'^cconds, penetrating cramp-like pain in 1. metacarpus, 15th, — In m. -^-^ gr. of 2nd. In \ h. aching in pit of stomach, and sensation like ^^^ratching in stomach ; after a time aching tension in 1. sacral region ^— rr ""^ hip, and in whole extent of pelvis, sometimes so violent that pelvic '^::^rx)nes seemed to be separating \ this lasted \ h. (in bed). After get- 1 -^ — ing up, urging to make water, with cutting pain (as in strangury) -m — ""*'• symphysis pubis. The whole forenoon sprained pain in 1. hip- "^oint (on walking), and very often gouty pains in joints of the ex- I -^cremities, alternating with cramp-like pains in their muscles (at rest ^H ^Buid in motion). About 2 p.m. (at rest) several violent shoots in tendo P^l ^chillis near os calcis. In 2 h. dull aching in whole of r. half of ' " "fcrain ; dimness of vision and weakness of both eyes, with innumerable ^ronrused dark spots floating before the eyes ; after this, long-contmued ^iddy confusion of whole head. At n., in bed, a semilunar painful ^_ tlrawing in root of nail of the r. little finger, i6th, — In m. 10 gr. ^H- In ^ h. (in bed) aching tension in 1. sacral region and hip, lasting ^H scleral m., and soon recurring. After this, very violent piercing, ^1 ^'''imp-like pain deep in r. orbit (probably in the muscles), which, as ' far as he could judge, seemed to extend through bony wall of orbit

'fito the frontal sinus; it lasted a h'w m., and then alternated with a "»iiilar pain in 1. orbit. After rising from bed a hard motion, causing P*in in its passage through rectum. About 10 a.m. a pretty violent ^''awing in 1. temple, which only lasted a short time. Before dinner ^^ observed, on inside of lower lip, a vesicle size of a hemp-seed, filled *yith dark blood, but it did not annoy him much, and after dinner was ^^und to have disappeared without leaving a trace behind. P.m., in '^^dition to a frequent alternation of the already described pains in head ^-»id joints, there occurred a violent, cramp-like, tensive pain close to r. ^^asioid process (at rest), which seemed to pierce into deepest parts of ^^ne j it lasted a few seconds, and then made way for a shooting pain •ti r. temple. E. (when at rest) a sharp cutting, from behind forwards, ^ong inner border of 1. great toe. 17th, — In m. 20 gr. On mucous •ncmbrane of r. under lip, two aphtha;, which went off in 2 d. Two h. after taking medicine, sudden drawing above r. eyebrow, and afterwards (at every step) dislocation pain in I. knee and ankle. At n., in bed, a pain piercing through r. knee-joint, which lasted 25 — 30 seconds, and was followed by a sharp cutting pain under nail of r, great toe. i8ih. — In m., after awaking, painful rubbing dry feeling in borders of r. eyelids, with cramp-like penetrating pain in r. mastoid process j after this, dryness of tongue, which, after \ h., gave place to slimy taste in mouth. A.m., painful cramp-like tension, now in muscles of anterior internal aspect of 1. thigh, now in I. calf. On inner surface of 1. lower lip he observed a group of greyish-white aphtha:, which were rather painful i after a time several aphthae appeared on r. upper tip (they lasted a week). About 4 p.m. griping in bowels from umbilical region

r

to the symphysis pubis, coming in fits, and followed by a diarrhocK evacuation of a yellowish-green, pappy, slimy mass, igih. — Feeling, of tiredness in 1. leg ; cramp-like penetrating pain in I. metaursal bones, and pain in 1, sole as if it were ulcerated. 20th. — In m. 5 gr. of i s^- In i h., in bed, violent pain in 1. sacro-lumbar region, worse on mrxiing in bed. After getting up, a hard motion, which causes cutting in its passage through rectum ; afterwards (on taking a step) shooti «g dislocation pain in 1. hip, which extended from sacro-lumbar regi ■<>«"> across pelvis to trochanter, lasted above ^ h., and caused him to linrmp- About I J a.m. giddy confusion in head with dimness of vision ; d •J' pressive headache, at one time deep in forehead, then in occiput, t»«-** always alternating with gouty pains piercing through joints of extret»"^ •" ties. About 7 p.m., when at rest, first a painful drawing along _ ^' tibia (feeling as if in periosteum), followed by very violent stitches ' " back, near 1. scapula. At n., in bed, there occurred, deep in r. side forehead, in a circumscribed spot size of a crown-piece, a slight di ging, shooting pain which lasted a few m. The night's rest was d turbed by anxious, half-remembered dreams. 21st. — In m. 10 gr, i h,, in I. sacro-lumbar region, an excessively violent, aching, tensi" pain, as if muscles were too short ; it spread over 1, side of pelvis trochanter, and even involved sympathetically the abdominal musci above crest of 1. ilium. This pain lasted as long as he lay on 1. side on turning it went off instantaneously, but then attacked same parts r. side. On getting up, no trace of backache, but, instead, dryness tongue and palate. P.m. (at rest), frequent painful drawing, now in head of fibula, now in 1. side of iorehead, now in I. elbo\ joint, and now in r. great toe. About 7 p.m., in open air, vcr_ troublesome confusion of head ; and in back, close to r. scapula, ai aching, tensive pain, as if muscles were too short. 22nd. — In mi 30 gr. In ^ h, dryness of tongue, and burning feeling in skin which"^ spread from axilla over r. upper arm and r. chest. Afterwards acric^ water ran out of eyes. The whole forenoon, frequent dislocation pair"^^ in joints, even on a slight movement ; and profuse perspiration wheir"^ walking. About noon, burning pain in a spot of skin size of a crown — piece over r. inner ankle. In e. fine burning, like sparks, on some« ^ parts of skin of r. upper lid. About 2 a.m. he awoke with aching pair in occiput, violent throbbing of all arteries of head ; painful dry sensation in both eyes; aching tensive pain in sacro-lumbar region •, prick — ling warm feeling all over skin, with disposition to perspire ; and troublesome burning feeling which extended from shoulder over 1, upper arm and between scapula;. 23rd, — A.m., at every step, sore feeling in abdominal parietes, as if muscles of abdomen and peritoneum had been bruised. About noon (at rest and in motion), in muscles of I, upper arm, close to bend of elbow, a cramp-like pain, which, in course of 2 h,, gave place to an exactly similar pain in sinews of 1. popliteal space. About 4 p.m., at first some griping in bowels, then call to stool, followed by pappy motion of yellowish-green colour, in moderate quantity. 24th, — A.m., frequent alternation of headache (at one time in forehead, at another in occiput) and the previous (gouty) pains in joints, but only when at rest ; when walking dislocation pains

)(

b pains

iJH

••^ 1. hip, and at head of 1. fibula, causing him to limp. About noon,

^«* Tning hot feeling in skin of whole back, especially annoying between

*«^^puli, lasting more than ^ h., and after scratching turning into sore

p*sm. in. In e., for a few seconds, shooting pains in r. side of chest

(j «jdging by the feeling, in the pleura), and several shoots through arms,

li Bee lightning ; followed by burning pain in skin of whole extensor

s B-arface of 1. elbow-joint. 25. — In m, burning and redness of skin of

^^v^- hole of dorsum of r. hand, as if an eruption were about to appear.

.J-^ _m. violent burning in skin of whole back, with perceptible throbbing

m. m~» arteries beneath skin at affected part, in c. several jerking, light-

B-» ing-Iikc shoots in rectum. The night's rest was often disturbed owing

c:«cr3 burning pains in parts of skin lain on.

The same symptoms recurred on the following days. The gouty lins in the joints lasted the longest, together with the burning in the tin, the shoots in the anus, and the cramp-like penetrating pains in deleft mastoid process. [Ibid.)

1. a. LoRENz K OSTLER, act. 25, first proved crude substance.

en powders, each containing 5 gr., which he took in October, 1845,

fz» 'oduced no effect. Nov. 4th. — 10 gr., towards e. headache and shoot-

» «rig in throat. 5th. — 10 gr., great confusion of head ; difficulty of

^ ■billowing ; stoppage of nose ; anorexia ; feeling of weight in stomach.

^« order to get rid of these symptoms, and to move the bowels, which

«2(i not acted for several d., he left off proving for 2 d. and took an

*-*unce of salts. This caused several motions, and gave him great

""^Jief. On 8th, 9th, and lOth, 10 gr. Beyond feeling of weight in

**omach, no symptoms, i Ith. — Same. On r. anterior border of tongue

• hard raised red spot the size of a lentil ; on moving tongue shooting P*in in it. 12th. — No medicine. The swelling and pains in tongue •''crc greatly diminishing, and the following d. were quite gone. 13th. — 'o gr., disagreeable metallic taste ; feeling of weight in stomach ; cruc- '*tions. 14th and 15th. — Same. The metallic taste and weight in fomach as on 13th, but no more eructations. Owing to a swelling of Sum and cheek, caused by cutting a wisdom-tooth, which lasted some <1. and returned slightly at a later period, he left off proving until 20th L>ec, On that and the 3 following d. he took every m., and on 24th, ■^5th, and 26th every e., 10 gr., but without any result. On nth,

titfi, 14th, 1 6th, 20th, 21st, 23rd, and 24th Jan., 1846, 20 gr. were ^akcn. 15th. — Occasional eructations and sour taste in mouth, lasting wveral d. 20th. — Feeling of weight and pressure in 1. side of chest, "liich increased daily, and was especially annoying on 26th. On that o- there occurred violent shooting pains at every attempt to move chest 'wwards and to 1., and on taking a breath. On the following days the •^"cst symptoms declined, and gradually went off completely.

A. *' For 4 weeks," says he, " I may have taken 3 times daily 5

g'obules moistened with the tinct., when I experienced a shooting pain

'fe and there in the abdominal parietes, especially in inguinal region,

** One time in 1., at another time in r. side ; this pain sometimes lasted

• *hort time, sometimes longer, but regularly went off in the warmth ?f ^d. As I did not believe that these wandering pains were caused ^ tlie S., I continued to take it. About a week after the first appear-

i86

ance of the shooting pains there occurred, on the slightest motion, t very troublesome feeling of fatigue. The shooting pains now gradually declined, but in their stead occurred contractive pains, espcdally '" muscles of thighs, which often proved a serious obstacle to my walitinj. In 4 d. these contractive pains were felt deeper, as if in the bones, especially in femora and r. tibia. The head of r. tibia became vcvj painful, and could not bear the slightest touch, and after the slightest movement I had to go and lie down. Now, almost convinced tl^^ these symptoms must be the effect of the S,, I intended to leave it c»ffi but as I had a few more globules I took them all. The consequen-^e of this was that the pains attained such a degree of intensity as almost to render walking impossible. The very next d., when I took no oi^" globules, the pains became less intense, and in 3 d. were all gon^- {Ihid.)

2 J . Franz Kurz, surgical student, act. 23, of sanguine-choler ^"* temperament and robust make, suffered for some weeks in 1845 frc^^^^*^ an herpetic eruption. Oct. i6th, 1845, "d the following 10 d., ^^ took 5 gr. of S. without result. Twenty gr. which he took on c " 27th, 28th and 30th were equally without effect. Nov, ist, 6 a.r^^lT 20 gr. About 4 p.m. some griping in bowels, soon followed ^^ a soft, very foetid evacuation ; disagreeable feeling of pressure umbilical region, and, notwithstanding the expulsion of much flat with smell of sulphuretted hydrogen, tympanitic distension of abd' men. and, about 3 a.m., profuse perspir.ition. At 6 a.m. 20 The same symptoms as yesterday ; but they came on a.m., and pc sisted during whole d. ; at same time violent headache and loss C^^ appetite. 3rd, at 3 a.m., profuse perspiration. At 6 a.m. 20 g.- Same symptoms as yesterday. 4th and sth, 20 gr. No mornin * perspiration, otherwise same symptoms as the previous days. I2tl. to 1 6th, 20th, 2 1st, 30 gr. The motions were more liquid, an- occurred twice a d. ; otherwise same symptoms as on 2nd. l2n(J^ 30 gr. Besides above symptoms, soft, small, quick pulse, 160 ; thdisagreeable pressure in umbilical region went off, but in its stead there-'' came troublesome pressure in 1. hypochondriac region, about 3 a.m.-^' which went off when he got out of bed ; in e. palpitation. 23rd anc^ 24th, same dose. Pulse on these days was less quick ; palpitatior^ occurred not only in e., but also after dinner, but did not last long i otherwise same symptoms as the d. previous. 25th, 30 gr. The pres^ — sure in 1. hypochonder disappeared, but came in still greater degree i gastric region. About 3 p.m., for an h. remarkable dilatation of pupils s^ in other respects same symptoms as on previous days. 26ih and 27th.—

— Same dose and same symptoms, with exception of dilated pupils -

28th to Dec. 1st, no medicine. The flatulent symptoms decreased ; stool as copious as before ; pulse normal. 2nd, 30 gr. The flatulent symptoms recurred to an excessive extent j motions were more fluid ; the pressive pain in gastric region went off, but affected umbilical region ; pulse more rapid ; no palpitation. From 3rd to nth inclusive, 30 gr. Same symptoms as on 2nd. No more medicine was taken. On 12th and following 4 d. same symptoms as before. On 1 6th they declined, and by 20th they were nearly all gone. [liitl.)

^1

-*P

.87

1. a, Jacob Landesmann, from 17th to 30th Sept., 1845, took daily JO dr. of 4th dil. i8th. — A small vesicle appeared in middle of Wtr lip, which dried up after a hw d. 29th. — In m. he blew some Nood-strcakcd mucus from nose. Along with some flatus several drops ofd/arrhoeic fjeces wtte involuntarily discharged. During d. 7. watery •tools with slight pinching in bowels. 30th. — About 10 p.m. some shoots in J. palm.

i>. From 1st to 17th Oct., he took 10 gr. daily of a 5-95 tri(, Beides increased secretion of urine, and diminished consistence of fttn, no symptoms until 14th, when a small painless vesicle appeared on each frontal protuberance, which remained there for several weeks, f. From 1 7th to 24th he took daily 5 gr. of S. rubbed up with sugar ; from 25th to 28th to gr., and from 29th to 2nd Nov. 20 gr. On i8th, on awaking in m., feeling of roughness in throat, and shooting piins on swallowing. These symptoms disappeared completely by the nm d. 20th. — A very violent catarrh came on, which lasted an unusually long time, viz., until the 20th Nov. From nth Nov. to '5'h Dec. he took daily 30 gr. of pure S. 13th. — Very soft stool and tniission of much flatus smelling of rotten eggs. 14th. — Same symptoms as yesterday. 15th. — On lip, near r. commissure of mouth, there appeared a group of small painful vesicles standing close together. '6tli. — ^The vesicles burst, and left behind them an equal number of ''J^all round spots, which, the following d,, assumed a lardaceous '''cerated appearance ; on 18th they began to dry up, and were covered ^m ^th a scab, which fell ofFin 5 d. 19th. — A.m., some sharp shoots in ^^J"- chest. Excessively irritable disposition without cause. Short dry ^■P^ugh in fits, frequently recurring. 20th. — At n. he awoke with ^^^^•«>Ient shooting pains in lower third of I. shoulder-blade, much ^F-^gravated by movement, but also so violent when quite quiet that he ^^^^:iuld not sleep all n. 21st. — In m. these pains extended further ^J)wards over scapula, whence they spread to muscles of nape and l.ear, ^^*id %rcrc worst when moving or turning the neck. They were less ^^iolcnt than in the n., and not so distinctly shooting, more drawing ^^nd tearing ; they diminished gradually during d,, so that he thought *^e had quite lost them. But in this he was mistaken ; for at n., * r warmth of bed, they returned with renewed violence. At last he ^cll asleep, but on account of the pains he passed a very restless n. He •tad never before experienced anything similar. 22nd. — In m., I h. ^fter getting up, the pain in 1. shoulder declined, and gave but little annoyance during d. There arose several small, painful elevations on

Ptlificrcnt parts of forehead and vertex ; one especially, on the skin between occiput and r. mastoid process, was particularly sensitive, and, along with the other elevations, lasted several d., when they gradually went off. About 7 p.m. drawing in r, spermatic cord and testicle. After lying down slight drawing in r. car, and fine drawing shooting in I. occiput — they were but slight indications of pains, only noticeable because such had never been felt before. The pain in I. shoulder continued in a slight degree, but did not much disturb the night's rest. a3r<l. — No new symptoms. a4th. — After dinner again a slight indication of the pain in r. chest which occurred on 19th \ afterwards slight

feeling of pain in the centre of the external aspect of r. thigh. At n - . after going to bed, very troublesome dry cough, which lasted unimex'ruptedly nearly \ h., whereby one or two lumps of albuminous-loolcin ^ blue mucus were expectorated. 2Sth. — He observed a scmilun»- * furrow, about a line in breadth, which extended right across bot.^^ thumb-nails, near their roots. The nail, both before and behind thL ^ furrow, formed an elevation. From 6 to 8 a.m. shooting pains in f tonsil, which, on swallowing, extended into 1. ear, and at same tim^^ (lasting till 9 p.m.) violent stitches, recurring every 10 or (5 m.-^ through whole length of last joint of r. index, at extremity of which an^almost cartilaginous wart had existed for several years. z6th. — In m. in bed, he experienced the pain in 1. scapula, but less violent than before, and nearer joint ; it lasted all d., and ceased towards e. The pain in last joint of r. forefinger also returned, but was not so severe to-day. During his proving he had frequently felt a cold sensation in I. upper arm, but never so distinctly as to-day. At noon dry cough, which lasted | h. The flatus occasionally expelled had a penetrating rotten-egg smell. The stool was very soft, and was preceded by griping in bowels. In e. drawing pain through first joint of 1. forehnger. 27th. — Frequent sneezing, discharge of fluid mucus from L nostril ; a very severe catarrh, although that which dated from the 20th Oct. had only quite ceased a few d. previously. At noon an attack of cough as yesterday. P.m. slight tearing pains in 1. eyebrow. 28ih. — In m., itching, causing him to scratch, on outside of 1. elbow, where there are a large and several small pimples. In e. frequent tearing in first joint of I. thumb -, after going to bed very annoying itching on inside of 1. knee, where also are several small pimples, which, however, like those on elbow, went off by following d. igth. — He observed, on nail of the 1. little finger, furrows similar to those on thumb-nails. 30th. — No new symptoms. In n. of ist — 2nd Dec, such violent itching on thighs and legs that he scratched till blood came. 2nd. — In e. frequent sudden tearing in I. cheek, in r. nape muscles, and in r. tibia. At n. again very violent itching in legs. 3rd. — In m. slight tearing in second joint of 1. little finger. Roughness of both cheeks, heat and burning in them, and sensation as if they had been exposed for several d. to severe cold ; this lasted several d., and was followed by a bran-like desquamation, which also lasted several d. P.m. occasional return of griping in bowels, and in e. a soft stool. 4th. — Colicky gripings in abdomen, which lasted all d. and all q., caused restless sleep, and only ceased following m. after a thin pappy motion. Betwixt ring and middle fingers of I. hand a small itching vesicle appeared. 5th. — The vesicle betwixt the fingers is larger, but only itches when touched. After dinner pretty severe tearing in 1. pectoralis major, lasting 5 m., aggravated by pressure. In nape on I. side, superiorly, a small painful pimple appears, 6th. — In e. severe itching in I. whisker ; after scratching, soreness of part. Long of falling asleep ; starting in a fright on dropping off to sleep; waking at 3 a.m. with aching in cesophagus, great flow of saliva into mouth, and clammy taste (as from indigestion), although he had only taken a light supper, with appetite. 7th. — In m. the gastric symptoms were gone. Mucus brought away

1 d

on Wowing nose has streaks of blood in it. The vesicle betwixt iiapn has attained size of a pin's head, is filled with a dear fluids and batMctlv the appearance of a fully developed itch vesicle. 8th. — No cluiigc. gth. — In e. tearing in 1, upper arm. During n. the vesicle tttffeen fingers burst. loth. — In e, tearing in r, cheek, nth. — Repeated flying tearing in both cheeks. 12th — 15th. — With exception of being later in falling asleep (often not until i or 2 a.m.), and violent itching in thighs and legs at n., no symptoms. i6th. — A hard, re^, painful pimple formed near angle of 1. lower jaw, and several itching pimples on outside of 1. elbow, whichj together with that on

jjw, lasted several d. before disappearing. i8th A.m., tearing pain

oniniidc of 1. little finger, increased by pressure. The itching on legs 10 bed at n., and the late falling asleep, continue. 21st. — At n., in IkiI, tearing under nail of 1. thumb. 22nd and 23rd. — Throughout d. feels quite well, but each c. for some h. continued colicky pains and incrcjsed flow of urine. 24th. — P.m., tearing in 1. tibia, and in e. drawing in 1. eyebrow. On two spots on vertex there are formed very tender, scabby elevations, size of a pea, which last several d. 25th. — Atn. very vivid anxious dreams, as if he was pursued by wild beasts. i6tli. — A hard pimple, size of a lentil, formed at angle of 1. lower jaw, ind persisted until ist Jan., 1846. The furrows on both thumb nails, wdon the nails of 1. little finger, which appeared in Nov., gradually filled up and were pushed forward by the growth of the nail, so that *fter three or four cuttings of the nails no trace of them remained. During the months of Jan., Feb., and March, 1846, the symptoms produced by the S. taken became gradually weaker and rarer. They mostly consisted of occasional flying pains in some of the finger-joints *nd other parts of the body, but especially of pimples and scabby wuptions which appeared here and there. Thus, on loth Feb. a furuncular pimple appeared on 1. temple, and several small ones on r. ™»utoid process, which lasted until 18th. On the i6th there appeared * painful scabby spot on the skin covering parietal bone, which "iiMppeared in the course of a few d. in order to make way for a '•milir spot. The consistence of the stools was remarkably diminished •during the whole time of proving, and the flow of urine increased, •he sexual power was weakened all the time of the proving, and for long afterwards. The difliculty of falling asleep lasted some weeks *fter leaving off the S.

rf, From 1st to nth June, inclusive, he took every m. at about 11 '3 dr. of tinct. ; from 12th to 21st, 20 dr. ; from 22nd to 27th, 30 dr. ; from 28th to 9th July, 40 dr. ; from loth to 19th, 50 dr. ; from 20ih

', '<' 19th, 70 dr. i and from 30th to middle of August, 1 00 dr. Besides "lucni sneezing, and sensation as if a cold were coming on, and fre-

l^cnt blowing from the nose of mucus mixed with blood (almost every

."■•J, no symptoms until June r5th. — P.m. a peculiar pain occupying

*J>icc size of a crown-piece, at first slight, but gradually growing

"'^ri and more severe. It was situated about 2 in. below lower angle '» scapula, and its character was long, pulsative, undulating stitches,

f'^ich always caused a jerk through whole body, and compelled him to

^^d hit breath (as when straining at itool). These stitches recurred

at totenrals of fnxn ^ to | h., during which time the spot alluded to was sensitive to touch, movement, and deep inspiration, but did not actuallj give paia. These conditions, however, had no influence on the shooting pain, which always lasted a few m. The pain continued all o^ and as it was even felt in sleep, it is manifest that that could not be very tranquil. i6th. — The pains continued in all their inten* sity of yesterdajr. He felt best when lying on 1. side. This posture be cndeaTOured to retain as much as possible during n., and by carefully avoiding tvming in bed, as the pains were thereby immediately aggravated, be passed a pretty good n. Besides the shooting pain, be WIS mubled by another symptom, viz. in e. a dry cough came on, excked by tkkltng in throat, and lasted a whole h. 17th. — In e. pain in back was more violent than on previous d. He was often forced to leave off speakii^ because the pain took away his breath. This he could stand no loag;er, so he cook bryonia, whereupon the pain declined in a firw h., and by e. was all gone. iSth. — On middle of lower lip tbere appeared two small white transparent vesicles, which increased in sice the fbUowing d., when they had the appearance of herpes labialis, and on the 20th began to dry up ; but in their place there appeared a number of similar but smaller vesicles on 1. side of lower Jaw, which also disappeared in a few d, 23rd. — He observed on first joint of r. ring finger a scabious itchy vesicle, which without increasing in sise lasted several d. before it dried up. A similar but somewhat larger scabious itching vesicle appeared on 27th, between 1. thumb and forefinger. 28th. — In e. he perceived on inside of upper lip, near r. commissure of mouth, a small painless elevation, which in a few d. changed into a small pedunculated wart with three free apices. It still remained months after the termination of the proving. From that d. forward, notwithstanding the increasing doses of sulphur taken, no new symptoms appeared. (liiJ.)

1. . Mayerhofer, on 28th Nov., 1845, about 9 a.m., took I gr. of I» trit. Soon afterwards strong taste of S. in mouth, burning on point of tongue, confusion of head and aching in forehead, constrictive pain in pit of stomach and feeling of sickness, wandering pressing pain in 1. hypochonder, chilly feeling extending from lumbar vertebr to abdomen and extremities. 29th. — In m. violent shooting pains came on in r. hip>joint, which compelled him to keep his bed, as he could not raise himself up or move without the greatest effort. This very troublesome shooting pain extended through r. half of pelvis dowii r. temur, avoided knee, and reappeared as severely in foot. 30th. — The pain abated, he could again freely move r. hip- and ankle-joints, and stand erect ; tenderness of joints, however, persisted, now more, now less, for 8 d. longer. During this time the bowels were very sluggish, and some d. not at all moved, gth Dec., about 10 a.m., he took another gr. In 20 m. heaviness and confusion of sinciput, and aching, squeezing, anxious feeling in pit of stomach, which gradually changed into a constrictive and alternately a burning pain. Two h. afterwards there came on a sensation of fulness of chest, at first an insipid and clammy, but suddenly a sweetish taste in mouth; sensitiveness of uvula > tickling in throat ; spitting of a watery slimy fluid

mixed with bright red blood several times, at short intervals. (He had had something similar 6 or 7 years previously.) Salivary secretion increased ; for a long time he had every now and then traces of blood in the saliva. Conjointly with these symptoms there was a feeling of fulness and distension of belly, and bearing down towards colon. Appetite diminished. After dinner symptoms in the pit of stomach declined, but the abdominal parietcs became sensitive, and the bearing down towards the colon increased. There ensued a loose motion ; the pulse was quicic, hard, and full. loth. — About g a.m. and g p.m., i gr. The feeling of oppression in pit of stomach less troublesome to-d.; in bones of arms and legs he had a feeling of weight j general wearinesSf and discomfort of whole body. Confusion in sinciput, insipid taste, appetite small. Constant bearing down in rectum, and a loose stool. In e., immediately after talcing the medicine, sweet taste in the palate. Contrary to the usual habit he was long of falling asleep, and when at last sleep came, it was disturbed by dreams of fire and death. 'tth. — In m., on waking, sensation of dryness in mouth, dry wrinkled lips ; taste clammy, tongue thickly furred with a dirty yellow coating ; aching feeling of weight in region of stomach worse than yesterday; great bearing down and feeling of fulness in the rectum ; he had not his usual motion of the bowels in the m. Confusion of the sinciput; annoying sensation of fulness in abdomen, followed by occasional tension and shooting pains. About 10 p.m. he took 2 gr. At n. vivid nxious dreams, frequent waking, and difficulty of falling asleep again. '^tti. — In m. dryness of lips, mucous membrane of which lies in folds; aridity of commissures of mouth, which are covered with small whitish scales } borders of the alse nasi dry, Schneiderian mucous membrane ' jf '^ated as if a coryza were coming on ; canthi of eyes red and inflamed, sj'ghtly adhesive, and exuding a little. Along with these, confusion of ^»r»ciput, oppressed feeling on chest, tenderness of abdominal parietes, nci bearing down towards rectum. After getting up and passing a "ard stool, all symptoms diminished, so that during d. he felt pretty "'^Jl. At 10 p.m. 10 gr. At n. vivid dreams. 13th. — About g a.m. ^ gr. Frequent sudden call to make water ; increased flow of dark- ^olouired urine ; constant bearing down towards anus, and feeling of '''^ess in umbilical region. Towards e. troublesome itching in scro- ^'^- 14th. — About II a.m. 3 gr. Sweetish taste, rush of water into . **^t:h, frequent eructation and yawning, fluent coryza, confusion of ?"^c-ipijt, aching boring pains in temples and cars (especially r.) ; draw- "^8 tensive pains in r. side of lower jaw, with painful tension and com- ['^^•^^ing swelling of r. submaxillary gland, feeling of fulness of the ^^'^T bearing down towards anus, clammy taste, little appetite, rigor ^'"ending from lumbar vertebrae over limbs, and at same time feeling <i istension and bursting of abdomen. Throughout d. itching in

turn. About 4 p.m. the rigor recurred, and this time was accom-

«d by painful shoots in urethra, and aching boring pains in bones of

^rm. In e. dull aching and feeling of weight in both eyeballs, with

of vision as if a thick veil were before eyes. Late in e., roughness,

,^ •^ess, and itching of skin on dorsum of r. hand ; some red, very

^ ing pimples on skin of r. thumb and its dorsal aspect towards mcta-

1^2

carpus ; roughness of skin between r. thumb and forefinger, worse in heat of bed. The night's rest was disturbed by boring tearing pain in teeth, which lasted all following d., and in n. of 15th attained such a height that he could not sleep a wink, in consequence of which he got a tooth, which was somewhat carious, drawn the following d. He discontinued taking the medicine for some d. During this time the exanthematic phenomena on r. hand continued, and were regularly aggravated by heat of bed ; the pimples gradually assumed the form of small pustules. The fxcal evacuations were far from normal, and sometimes ceased altogether ; the fzcal matter was sometimes firm, sometimes relaxed.

i. 20th. — About 10 a.m., 3 gr. Confusion and aching in sinciput as if a band were tightly tied round forehead ; itching in scrotum, and ineifectual straining at stool, with dull, shooting aching pains about navel. Towards e. several small, reddish pustules in skin of r. thumb, near metacarpus, which itched excessively. 21st. — After repeating about 9 a.m. dose of yesterday occurred violent fluent coryza; hara stool (about noon) ; frequent urination, urine the colour of sherry wine. P.m., itching, burning, and redness of edges of lids and of skin on outside of nose. Towards e. great tenderness around anus, and sudden, jerking, very painful stitches, first out of r. and then out of I. half of anus j they were so violent that they made him start up from his seat ; at same time chilly feeling in legs. In e., in bed, itching and burning on dorsum of r. hand, which became covered with elevated, red, and itching pustules, which went oft" during n. (The swelling of the r. submaxillary gland, which commenced on l+th, has increased «omewhat in size to-day, and feels moderately hard and tense.) 22nd. — Itching betwixt lingers of both hands ; inefficient call to stool ; urinary secretion increased, urine of bright yellow colour. Towards e. a red rough round place, an inch in circumference, appeared near union of ring and little finger, on which reddish pustules appeared, which itched very much in heat of bed. About li p.m., 4 gr. Soon afterwards confusion in forehead and temples, and aching in pit of stomach. Sleep disturbed by vivid dreams. 23rd. — About 8 a.m. 4. gr., and about lo p.m. 6 gr. In m., after much straining and cft'ort, a motion, at first hard and afterwards loose. Appetite was diminished, and after taking but a small quantity of food he had feeling as if stomach was overloaded. Urine of a bright colour was passed in considerable quantity. Feeling of weight in humerus. In e. after taking medicine, sweetish taste in mouth, great flow of saliva mixed with blood, confusion of sinciput when lymg, contractive pain in forehead and temples, aching and oppression in pit of stomach ; then very heavy sleep, disturbed by dreams, from which he awoke after 3 h. with confusion and weight of head, clammy taste in mouth, fulness of belly, tension and drawing round in a circle about navel, feeling of coldness and irritation in rectum, urgent but ineft'ectual call to stool ; after passing much flatus of the smell of rotten eggs, and a great flow of urine, these symptoms diminished. 24th. — In m., heaviness, confusion and dulness of the sinciput, clammy taste, thickly furred tongue, urgent but ineffectual call to stool, with drawing and tension down muscles of loins, discharge of much flatua

^93

the smell of rotten eggs. These symptoms connected with the reU recurred twice, namely at noon and in e. About noon annoying itching in scrotum and on back of hands, with tickhng, itching, and ifore feeling at outer border of anus. Swelling of submaxillary gland tcrc;iscd. At n. vivid dreams and uncommon sexual excitement 15th. — The exanthematic phenomena on dorsaof both hands declined ; ching and redness of scrotum persisted in same intensity. After linner a hard stool, followed by sore feeling at anus. Night's rest iisturbed by many vivid dreams. 26th. — In m. ineffectual urging at nool i severe fluent coryza. Swelling of submaxillary gland grew ,\ta, At 10 p.m. 6 gr. Many vivid dreams, causing a restless n. 17th.— About 9 a.m.,8gr. In an h. anxious aching in pit of stomach, confmion of sinciput, sweet taste, great flow of saliva into mouth, bloody streaks in saliva. In 3 h, rigor over whole abdomen, feeling of fulness there, bearing down towards anus, jerking stitches through its r. hilf, itching in it, and feeling as if it were sore, swollen and moist. Pm., anxiety in chest, difficulty of breathing, cough accompanied by ihootine pains in chest, increased secretion of saliva mixed with streaks ofblooJ. In e., after much straining, a firm motion, accompanied by ngor proceeding from lumbar vertebra;, and cold feeling in limbs, specially lower ones ; violent itching and tickling in point of nose, whicli is red. About 10 p.m., 8 gr. At n. many dreams, hence nttkii sleep and frequent awaking, each time with feeling of weight and dulness in sinciput. 28th. — About 9 a.m., 8 gr. A.m., after much effort, a hard stool ; tongue furred ; appetite diminished j throughout d. squeezing pressure in pit of stomach and in chest. In e. troublesome itching in skin of nose, which is slightly red, particularly •ttip. At n. many vivid lascivious dreams ; frequent emission of urine tlitcolour of sherry. 29th. — Without medicine. In m. feeling of weari- !"*» and heaviness in legs ; confusion of head. At noon piercing, jerking stitches out at anus, which was then so sensitive that he could fKt remain an instant seated ; with every stitch dull shooting and jerk- "'gpjins in the r. inguinal region; sore feeling at anus, and escape of mwjturc from it, itching in skin surrounding it ; distension of belly, '" ipite of a great discharge of flatus smelling of rotten eggs ; annoying ""(ineffectual urging to stool. At n., after much eftbri, an unsatis- "ttory motion, with frequent and increased emission of urine. 30th. ""About 8 a.m., 10 gr. A.m., feeling of constriction of chest, and *«vefc aching in pit of stomach ; confusion of sinciput ; diminished appetite; sweet taste ; copious secretion of saliva mixed with streaks of ^oodj contractive pains about navel ; troublesome and ineffectual ^"ffting to stool. The pustules on back of hand decreased in size, but .' continued violently, especially in warmth of bed, 3l8t. — ^ r submaxillary gland quite gone ; sinciput oppressed i itching Itu ihc jcrotum very troublesome ; the exanthematic symptoms on back fWhinds diminished ; evacuation after great effort, ist Jan. — Itching [•oiijore feeling at border of anus. P.m., itching and smarting in bend Ijf^tlbow, where, in e., several pimples on a red spot appeared. 2nd. — He symptoms. 3rd. — In e. 12 gr. In i h. feeling of pressure atid "'ight in pit of stomach, and difficulty of breathing ; dull aching in »ot. IV, 13

•94

forehead ; tension in belly, especially in umbilical region. At n. i itching here and there, but especially on scrotum. Many vivid dreams restless sleep, 4th. — In m. awoke unusually early with confused ' head ; feeling of weight in pit of stomach, and very great itching on scrotum and inside of thighs. Afterwards there occurred tensive pains about navel j urging to stool, and, after much effort, an insufficient hard motion. Urine, which was in larger quantity than usual, was the colour of light sherry, sp. gr. 1019, Appetite diminished ; he ate rather from habit than from necessity. After eating, disagreeable feeling of weight in gastric region ; recurrence of urging to stool, and after much straining a soft formed evacuation. Urine, discharged in greater quantity in e., had the colour of white wine, and a sp. gr. of 1015, Whilst urinating, and for I h. afterwards, rigor, which extended from lumbar vertebras over abdomen. At n, great itching on dorsum of r. hand, especially on little finger, where he found, the following m., a pustule with its head scratched off, which had a great resemblance to an itch pustule. 5th. — In m. there appeared on I, ala nasi, towards cheek, a small distinctly pulsating swelling. Towards noon there appeared, below 1. commissure of mouth, several itching pimples, and on anterior surface of 1. thigh several itching pustules like scabies. 6th. — In m. 1 2 gr. Soon afterwards feeling of pressure in pit of stomach ; frequent yawning and eructation of air. Towards noon peculiar feeling of trembling and throbbing in chest and pit of stomach ; bearing down towards anus, itching shoots there ; fluent coryza ; feeling of weight in r. arm. Skin was reddened on several places, and itched. Urine passed after eating, in small quantity, had colour of dark sherry, and a sp. gr. of 1026. P.m., drawing tensive pain in r. hip, extending down thigh. In e. several very itchy pimples and red spots appeared on thighs ; the pimples beneath 1. commissure of mouth were gone -, the small pulsating tumour on ala nasi burst and discharged pus ; the pustules on little finger and on 1. thigh dried up. At n. many disturbing dreams ; waking about midnight and remaining a long time awake. 7th, — In m. bearing down towards anus and call to stool, but ineffectual, as nothing but flatus came away. It was ohly towards noon that after much straining a formed soft motion was passed. In e. tensive drawing pain in 1. thigh ; bearing down towards anus. At n. intense itching at anus, and following m. escape of an acrid itching fluid from it. He now left off taking medicine until 13th. During this time, sometimes one, sometimes another of the above-described symptoms occurred, more or less severely, but the cutaneous symptoms were most observed. The symptoms connected with the anus declined after 2 d., but the motions continued to be very irregular. The fluent coryza, which annoyed the prover more or less during the whole of his proving, disappeared.

c. 13th. — In e. 18 gr. Soon afterwards, oppression in sinciput ; contraction and pressing in forehead, and aching in pit of stomach. At n. many disturbing dreams, and frequent waking with pains round navel j aching in humeri. 14th. — In m. dryness and tension of skin of lips ; clammy taste ; empty feeling in head ; bearing down towards anus and urging to stool ; after the greatest straining there passed a

'95

sooty, soft formed stool. Towards noon abdomen was swollen and distended ; bearing down towards anus again occurred, and after much effort inothcr loose stool. Appetite diminished; itching on dorsa of kinds worse, but pimples smaller. About 6 p.m. the abdomen again distended, and a disagreeable feeling of fulness about anus was expenwced. The fluent coryza again appeared^ and along with it confujion of head, aching in forehead, and oppression of chest. About 8p,m. great flow of sweetish saliva into mouth ; tickling in 1. nostril, immediately followed by discharge of bright red thickish blood, to the utcut of about { drm., which contained a proportionally large quantity of sulphates.* 1 6th. — M. and e., 20 gr. In an b. duliiess and oppression of sinciput ; in frontal bone a painful aching, which extended across nasal and both malar bones ; feeling ol fulness and tension in abdomen. At noon appetite was very poor, and after eating there was troublesome feeling of fulness in stomachy and aching in scrobiculus cordis. Soon afterwards violent bearing down towards »nu5, discharge of much flatus, and at length, after much effort, a hard motign. In e. itching behind r, ear, where several scattered pimples hid formed. Somewhat later, not only did all the symptoms return which had troubled him before and after dinner, but in addition there uccurred anxious feeling in the chest, he can hardly expand it during uupiration , itching in r. concha } boring pains in meatus auditorius enernus ; copious secretion of car-wax. The night's rest was disturbed by vivid lascivious dreams, causing two seminal emissions ; after midnight he awoke in a fright, caused by a dream, and felt aching drawing pains in both humeri, tensive and cutting pains round about iivd, and very urgent but ineffectual call to stool. 17th. — The same 'ymptoms as yesterday. In m. urine, which was passed in considerable Swntity, hid a dark sherry-wine colour, and a sp. gr. of 1018. 18th. —A.m., when standing, jerking stitches in anus ; little appetite; during d.2soft formed stools. 19th. — Painful drawing in muscles of r. thigh, •oihat he could scarcely raise the leg or move it about. In course of d. i soft formed stools.

d. On igih, e., took 2 gr. of S. in substance. Sleep disturbed by ■niuy vivid dreams ; frequent awaking with disagreeable itching on |«venl parts of skin, causing him to scratch, and drawing tearing pains 'B metatarsus and toes of r. foot. 20th. — In m,, after awaking, vacant confused sinciput, and bruised feeling of whole body, especially arms. During d. 3 soft formed evacuations after great effort. Urine was of a ''ght sherry colour, and its sp. gr. 1015. In e. 4 gr. Restless dreamy sleep-, frequent awaking with cutting pains about nave! and distended ihdomcn. 21st. — In m, 4, in e. 6 gr. M., on awaking, vacant con-

• " 1 must ob»erve," says M — , " that iincc oommencing my proving of S. 1 have ^Wied t considerable weakiicu of vi^ion, and very often a feeling of heaviness and tiling in the eytballN. When reading or writing I often feel as if a mist were bclorc l^itryiv I inu%t then first cover the eyes with the hand, slightly press and rub them, iooMjcr to be able to read. Moreover, I must hold the book 1 am reading a con- •Hltrable disLuicc from the eyes, tor when 1 hold it close I cannot distinguish tile Ittitn. I had previously noticed a slight diminution in my visual powers, but since P«wing the S. tnc feeling of weight and aching in the eyes and the weakness of sight ttavc increased rapidly, and to a great extent."

19b

fusion of head j dryness of tongue and palate; arid, wrinkled lips j tension of skin surrounding mouth ; clammy taste ; aching and full feeling in scrobiculus and gastric region ; bruised feeling and heaviness of limbs. At noon but little appetite, he ate more from habit than necessity. During d. aching in pit of stomach ; heaviness and tension in humeri ; feeling of soreness of anus, and exudation from it of viscid, slimy fluid (which probably occasioned the feeling of soreness In e , soon after taking medicine, duiness and oppression of sinciput aching in forehead. It was long before he fell asleep ; at length he did so, but in an h. he wolce up again, and was unable to fall asleep agai. before 4 a.m. During this time dull aching and boring in frontal bon and constant desire tostretch out limbs. 22nd. — In m., after awakin; from his short sleep, which had been disturbed by confused dreams, bruised feeling in limbs; vacancy and confusion of sinciput; painful aching in frontal bone, and boring pains in r. supra-orbital ridge. Lip« were dry and shrivelled ; tongue thickly furred ; taste clammy, insipid ; palate dry. After getting up, cutting about navel ; discharge of much flatus ; and, after much effort, a soft formed, insufficient stool. In e. 6 gr. Soon afterwards recurrence of the discharge of flatus, and very troublesome but ineffectual call to stool. Night's rest disturbed by many dreams. 23rd. — Without medicine. The same symptoms as yesterday. 24th. — In m. 8 gr. A.m., horripilation extending from spine over abdomen, back, and upper extremities ; and, at the same time, uncomfortable feeling of weight in whole chest and in bones of both arms. At noon little appetite, and no desire to drink water while eating, which he was always in the habit of doing. During d. 2 soft formed stools. About 7 p.m. recurrence of horripilation as a.m he felt now too much affected by the S., he left it off for 3 d. complexion,^' he writes, "showed a remarkable change, it had a di earthy appearance ; and since taking the S. in substance the sexual jiower is remarkably diminished."

f. 27th. — In m. 10, in e. 12 gr. During forenoon heaviness and aching in pit of stomach. At noon no appetite. Towards e. severe aching in frontal bones ; weight and full feeling in chest, and shortness of breath. In e., after taking medicine, vacancy of sinciput } aching in frontal bones and pit of stomach. When lying in bed, rigor, proceeding from r. side of lumbar vertcbrat and spreading over r. side of the body. At n. restless, dreamful sleep. 28th. — ^In m., after waking, vacant confusion of sinciput ; very troublesome feeling of outpressing, bursting and boring in frontal and cheek bones ; dryness and tension of outer skin round about lips, and bran-like desquamation of it ; dryness of lips and palate ; dryness and burning of tongue, which was covered with a dirty whitish-yellow fur ; aching and weight in scrobiculus cordis ; tension and swelling of belly ; cutting pain around navel, worse on stooping; discharge of much flatus with smell of rotten eggs ; violent but ineffectual call to stool ; borders of anus were somewhat swollen, and he felt a tickling there as if a worm were creeping about ; escape of a small quantity of slimy fluid from anus. In limbs, especially upper ones, a bruised and heavy feeling, which lasted all d. Towards noon, after a painful effort, there occurred

soil lir^

»97

Kanry motion ; feces were firm and of a blaclcish-brown colour. In c. I4gr. Soon afterwards the same symptoms as yesterday. About midnight he awoke, and could not fall asleep again for a long time. During this time he experienced a great amount of the pains in frontal and malar bones, and in limbs. 29th. — Without medicine. In m. oU to stool, and only after a great effort an insufficient evacuation of a ink hard ma$s. The night's rest was disturbed by vivid dreams, frequent waking and lying long awake, with great restlessness and adtcment. 30th. — M. and e. 16 gr. In m. a movement of bowels iftcf much straining ; a.m., confusion and aching in sinciput ; aching in pit of stomach and in stomach; difficult breathing; increased heat of hands, and increased itching on their backs, which, especially r. thumb, are covered with red irregularly shaped pimples. On inside of nose, especially on alx nasi, great itching and feeling as if nose were swelled. Near outer canthus of 1. eye an intensely red, excessively Itching and burning spot on skin ; I. palpebral conjunctiva much reddened. Feeling of fulness and tension in abdomen ; bearing down towards anus, and excessive tickling there. Towards e. the aching in pitof uomach returned in a greater degree than a.m. ; breathing very difEcult. Again call to stool, and with great effort evacuation of hard dark-coloured fxces. R. submaxillary gland was again swollen and sensitive to touch, and thus it remained for 2 d. In e. after taking ^ the medicine same symptoms as on tivo previous d. At n. voluptuous JH dreims and seminal emission. From 31st Jan. to iith Feb. ^M induiive be purposely abstained from taking any more medicine.* In ^1 id. pains in the frontal bone and restlessness at n. with vivid dreams P »wc gone. The feeling of emptiness and confusion of head, the pains iapiiof stomach, and the disorders of digestion, lasted till 7th Feb, The symptoms in the rectum and the irregularity of the motions feouined. On 1. upper arm there appeared reddish pimples, similar to those that had previously affected thighs and r. hand. 12th Feb. — In m. he again took 4 gr. of S., and there appeared confusion of head ; >aching in frontal bone; aching and feeling of weight in pit of stomach. ^ At noon he had an uncommonly good appetite ; at n. very vivid B ^tnSy out of which he often awoke, and could not fall asleep again ^ for i long time. 13th. — Without medicine. In m. confusion of head; aching in frontal region; aching in sternum and oppression of breath ; after much effort a scanty evacuation. At noon uncommonly

• "Since the eleven days," writes M — , "during which I have taken the S. in sub- Raare, my system seems to be thoroughly penetrated with it, and I think it right to inm nti,,<:<] notice to the following:

"c ' ully and irregularity of the motions, which may be caused by a peculiar

piort'j 'H of the large gut (especially of the sphincter an i), shown by the

ittiog pain^ around the navel. ^*. The remarkable .iiminution of the itxual ponuer, especially by day.

', T^r ahnormal .ippcar antes in the skin. Before the proving I had generally cold

now the hands are often wann, turgid, swollen, and disposed to perspire. The

of S. to irritate and disturb the functions of the skin was shown on several

Mfts of the cutaneous surlace by abnonnal feelings (itching, burning, &c.} and

rarmat]on» (pimples, vesicles, &c.).

** 4. Tlie boring, aching, bursting pains in the frontaJ and malar bones, and the adiisg, heaviness, and bniiscd feeling in the limbs,"

t

good appetite i disturbed night's rest as yesterday. 14th. — Inm. 4gr. Same symptoms as on the previous d., and in addition several te4 itching pimples and spots on bacic of r. hand, and several vesicles on upper lip, which burst and let out an acrid yellowish fluid 5 at same time tension in skin round mouth, which was covered with bran-ltlce scales.

f. To the history of the symptoms he observed, the prover adds the examination of his urine, which gave the following results.

Ai regards the quantity, — " In order," writes M — , '* to decide the question as to the influence of S. in increasing or diminishing the secretion of urine, during the whole time of the proving from 20th to 31st Jan., 1846, I ate about the same quantity of food every d. and measured the fluids ingested. The following results were observed : ,

Period! of 14 hwirf.

Quintity of fluid taken.

Number of fml«. Toul weight o( flons of artnc. urine.

From »o to 21 Jan

1. S» »

74 •! 60 „

5» 1. 63 .. 54 »

6 50 oz.

• 3= » 4 18 „ - 6 6t „ I 6 ?■» . 1

« 31 .. 33

3 J „ 34. ,

,, 14 „ 35 „

„ 37 ,, 38 „ ,,.,

„ 38 „ 39 ,,

6 9

5S >. 41 .>

II 3° II 3' >•

" From these observations it appears that whilst I was taking the S, a quantity of urine corresponding pretty well to the food and drink taken was evacuated. It is generally assumed that a healthy tnsui passes 48^ oz. of urine in the 24 h. ; but this is an over-hasty assumption, as many circumstances, but especially the quantity of fluid conveyed into the organism, have a great influence on the urinary secretion. During my proving of S. my stools had very little fluid or watery constituents. I had never any disposition to perspire, I only do so after any violent bodily exertion, such as very rapid walking ; and marked though the action of S. on my skin was, it never produced copious perspiration — hence no fluid could escape out of my body in that way. Only once, on 23rd Jan., I perspired profusely in consequence of walking rapidly, and to this circumstance I must ascribe it that from 23rd to 24th, although I took 74 oz. of fluid in my food and drink, the urinary secretion was so small, and only 38 oz. were passed. From my observations I conclude that from the 20th to the 31st Jan. the S. I was proving produced neither an increase nor a diminution of the urinary secretion,"

As regards the physical and chemical properties. — "On the 22nd December, 1845," proceeds M — , " I examined the urine passed in the c. in regard to its chemical constituents. It had a very pale white wine colour, and almost the appearance of so-called spastic urine; when first passed, and after standing for some time, it was equally pure and clear, and had a sp. gr. of 10 18, that is, less than the normal. It had a marked acid reaction. When heated a slight cloudiness appeared

which, however, went off on adding nitric acidj and hence was not owing to the presence of albumen. The addition of nitric acid caused an immediate deposit of urate of ammonia in fine grains, which, on allowing the urine to stand, appeared in the form of a brownish-red undy sediment. The urine treated with muriatic arid, and allowed to stand, after being well shaken deposited an increased quantity of uric acid. This was precipitated in a reddish sediment, or deposited itself on the inside of the glass cylinder, but it was frequently combined with ammonia. Evaporated to the consistence of syrup, then cooled and treated with nitric acid, it showed a smaller quantity of nitrate of urea than in the normal state. After the addition of ammonia there occurred a copious precipitation of earthy phosphates in increased quantity. Acidulated with a few drops of nitric acid, the addition of muriate of bar}'ta showed the presence of a large quantity of sulphates. An equal quantity of urine, acidulated with nitric acid, precipitated the normal quantity of chlorides on the addition of nitrate of silver, and the presence of phosphate of soda in large quantity was demonstrated by the appearance of a thick greenish opacity, on adding a few drops of ammonia to the filtered fluid until it was neutralised. The uroxanthine was diminished. Urine of the same character as that subjected to examination, namely, with an increase of the sulphates, the urate of ammonia, the earthy phosphates, and the phosphate of soda, frequently occurs in rheumatic affections of long standing, and in chronic skin diseases. Them, and e. urine of 23rd Dec. had asp.gr. of 1015 and 1016, little ammonia, much free uric acid, and nearly a normal proportion of sulphates. The urine examined on 24th had a sp. gr. of 1 021, that of 28th 1 010, and that of 31st 102 1. As regards their constituents, however, they exactly agreed with the urine of 22nd, The urine passed in m. of 7th Jan. was of a dark sherry colour, clear, deposited no sediment, had a strong acid reaction, and a sp. gr. of 10J7. Boiling produced no change in it ; the addition of nitric acid showed nothing abnormal. The earthy phosphates, sulphates, and uric acid were increased, the chlorides normal, the urea lessened. The m. urine of the 8th was pale bright yellow, clear, without sediment, acid ; it had a sp. gr. of 1020. No change on heating it, or on the addition of a small quantity of nitric acid. A larger quantity of nitric acid caused a violet tint, showing the presence of uroxanthine. The earthy phosphates, the sulphates, the phosphate of soda, and the uric acid, were increased, the j:hlorides normal, the urea decreased. Quantitative analysis :

Water ... 957"6

Solid constituents . . . 42*4

Total

... 1000

Solid constituents :

Urea ...

...

. 19-80 gr

1 Uric acid

...

225 „

^_^ Fire-resisti

"g

salts

8-40 „

^H Extractive

matter

1 1 '95 «

Total

42-4

f

SULPHUR.

Among the fire-resisting salts the sulphates were specially abundant. The m. urine of the gth was of pale sherry colour, clear, without sediment, sp. gr. I02i. No change from heat or nitric acid. The uric acid and all the salts increased, only the chlorides normal, the uroxanthine abundant, the urea diminished.

L Quantitative analysis :

I Water

^^m Solid constituents

r

unc ac

956-3 437

Total Solid constituents : Urea Uric acid Fire-resisting salts Extractive matter

1000

t8'40 gr.

4"00 „ 16-25 »

5-05 „

"The m. urine of the 14th had a sp. gr. of 1019; sulphates and uric acid were very abundant. The m. urine of the 15th had a sp. gr. of 1023, and a great deal of uroxanthine; otherwise quite similar to that of the previous d. From 20th to 31st Jan. I made almost daily quantitative and qualitative analysis of the urine. The m. urine was usually of a pale sherry colour, clear, and without sediment; the urine passed after dinner or in e. was of dark sherry colour. The sp. gr. on the 20th was 1015, and the following 5 d. 1022. It had generally a strong acid reaction ; heat caused no change, except a slight cloudiness on one or two occasions, which must be ascribed to the frequent presence of proteine compounds. No change was caused by adding a few drops of nitric acid, but from an excess of the acid the urine assumed a brownish-violet colour in consequence of the presence in abundance of uroxanthine. The urea was as a rule diminished, the chlorides generally normal, the earthy phosphates somewhat increased, the phosphates of soda and the sulphates much increased. The uric acid was deposited in much greater quantity than in the normal state, but was of very loose texture, and hence a large quantity weighed very little. Thus the urine of the 22nd contained in looo parts 9436 of water and 564 of solid constituents, and among the latter the uric acid formed only the 0'365th part. The urine of the 21st contained in 1000 parts 9496 of water and 504 of solid constituents, of which the sulphates formed the 0"65th part. The urine of the 28th was also of a bright yellow colour, clear, without sediment, strongly acid, its sp. gr. 1 01 6, but otherwise resembling that of the previous days. The quantitative analysis showed in 1000 parts 961 '6 of water, and only 384 of solid constituents. The uric acid was abundant. I took 25 grms. of urine, precipitated the sulphates, and obtained 014 parts of sulphate of potash, which consequently in the proportion of 1000 parts showed the presence of the considerable quantity of 5"6 parts. I allowed a quantity of urine to stand undisturbed for 24 h. in a glass cylinder ^ there occurred a great cloudiness, and there was deposited a cloudy, thick, bright red sediment. But as both cloudiness and sediment disappeared

under heat, it was evident that it consisted of urate of ammonia. On heating recently emitted urine in an ammonia apparatus, the vapour arising tinged the litmus-paper blue, and the same reaction took place on adding caustic potash, which expelled the ammonia. Thus for 3 d. there was free ammonia in my urine, which does not and should not occur in normal urine, and is to be ascribed to the action of the S. The urine of the 29th, 30th, and 31st was of a dark sherry colour, clear, without sediment, had a specific gravity of 1018 — 1019, and was not changed by heat. The proper reagents demonstrated the presence of carbonate of ammonia ; heated with nitric acid, the colouring matter showed itself by a brownish. violet tint ; sulphuric acid struck a purple colour. The urea was, as usual, small in quantity, the chlorides normal, the earthy phosphates abundant, the sulphates and the phosphate of soda very copious. The uric acid, which was deposited in great quantity, was combined with ammonia. In the urine of the 30th and 31st were traces of iron ; there can be no doubt that it came from the blood by a peculiar process of excretion, probably induced by the excess of S." (/A;W.)

1. Dr. J. O. MiJLLER made trials of the looth and 30th dils., but elicited from them no effects worth notice. — On 21st Dec, 1845, before going to bed, he took 2 dr. of 6th dil. in water. The n. was undisturbed. "22nd. — In m., soon after wakings head hot, slightly confused ; these symptoms went oft after washing. The whole forenoon a sute of mind partaking more of earnest exaltation than of depression or want of cheerfulness ; weight in small of back, felt particularly on stooping; painful drawing about hypochondria; insipid taste; dirty, thinly coated tongue. At noon, after walking much, I felt hungry, but without appetite. Without feeling satiated, the latter part of the meal was not relished. Throughout d. great discharge of flatus and rumbling in bowels. In m., afternoon, and c., always soon after eating, passed a motion, half fluid, half lumpy, mixed up with gas, and attended with great noise from flatus. Frequent and copious evacuation of pale urine, with but little odour (only towards the end it had a mouldy smell). Sore pain in whole abdomen, as if it were raw, particularly noticeable on taking a full breath, coughing, walking quickly, or taking any violent exercise. Itching at anus and round about it. 23rd. — Restless dreamful sleep ; frequent waking and falling to sleep again in a stupefied state. Towards m. general warm perspiration with anxiety, causing him to throw off the bedclothes. Pain in small of back with hypochondriacal discomfort. No appetite, and yet the food has the proper taste. Very tormenting shootings behind lowest 1, rib towards back, increased by breathing deeply ; at same time rattling respiratory noise in the large bronchial tubes. Eruption of furunculous pimples with a red areola, and very itching sensation, especially on face. Frequent itching, burning, and smarting in canthi of eyes, making him rub them. In e., by candlelight, a veil before the eyes ; surrounding objects appeared to be enveloped in smoke ; rubbing and wiping them had no effect. Tormented with flatulence. The accustomed motion did not take place j flow of urine also was less frequent and scanty. 24th. — Very restless n. ; dreams of unfortunate and

dishonouring events. Waking up in anxiety, heat^ and perspiration. Redness of eyelids and conjunctiva. Gasping for breath, on account of constriction of larynx ; throat appeared to be too narrow ; face hot and turgid ; eyes perceptibly projected out of their orbits ; veins of forehead and temples were distended with blood ; speech difficult ; shrill whistling on inspiring, particularly noticeable on going upstairs. This very anxious state was accompanied by indescribable discomfort, want of steadiness, and dizzy feeling. Firm stool, with severe pressing. 25th. — N. as before, very restless. P.m., a peculiar discomfort in precordial region and hypochondria, extending up to throat, caused by tension, pinching, and tearing, now in stomach, and now in splenic and hepatic regions ; eructation of flatulence caused only slight allcvia* tion. At this time I was obliged to devote myself to an intellectual work, which occupied my attention and disturbed my night's rest so much, that I discontinued the trial on the 26th, from which date I recorded no more symptoms." {Ibid.)

1. a, A girl of 27, of healthy appearance, robust, well-formed figure, black hair, and good complexion, of variable but generally cheerful disposition, with no perceptible ailment, regular menses 5 after having taken dilutions (looth, 30th, and 6th) without effect, took on 2Sth Dec, at 3 p.m., 5 gr. of the l^ trit. mixed with water. The next d. the usual m. motion did not occur ; it was not till p.m. that she had an unusually hard stool, accompanied by pressing and burning in anus. The burning lasted some time after the motion, so that she could not bear to sit. 29th, — At 3 p.m. 5 gr. of same. In e. violent itching and smarting all over body, particularly on and betwixt fingers ; parts of body not sensitive itched when she touched them. She feels as if she were all alive beneath the skin ; there was a feeling as if vermin were running about. No stool to-day (her bowels arc always quite regular every d.). 30th. — N. very restless; anxious frightful dreams of the dead and dying ; she speaks, weeps, and shouts in her sleep, so as to wake herself, and after awaking remains long in a confused state of mind. In m., after getting up, very much out of humour ; during d., sad, lachrymose — she weeps if one attempts to console her. Makes mistakes as to time : she thinks it is much earlier than it really is; at the vesper bell (7 p.m.) she contends with warmth that it is only 5 o'clock, and becomes quite angry on an attempt to convince her of her error. No appetite ; no stool. Shooting pain in temples, close to eyes, on moving them or on looking at anything. 31st. — Atn., when lying on back, pressure and anxiety in chest, with difficulty of breathing, to such a degree that the sweat exuded at every pore. She feels very weary, prostrated, and ill j complexion is pallid j natural tension of the facial muscles gone, so that her features appear discomposed, as if worn out by long suffering. Anorexia; what she eats has no taste, she has no relish, and the morsel seems to stick in her gullet. In e., cramp, stiffness and icy coldness of 1. ring-finger, extending up to elbow, corresponding to the seat of common extensor muscle. Severe pain in small of back, extending from hypochondria over the sacrum into the coccyx, and she felt as if everything would come out at anus. At n., when lying on back, troubled with colickj

n colicky 1

A

Wlyache, with cutting in sides of abdomen, and drawing together about navel ; this was followed by a scanty evacuation, with much tenesmus and severe burning in anus. 1st Jan., 1846. — She feels quite prostrated and ill. Severe pain in small of back, on account of which she loses all power of supporting herself. Burning in anus so thai she onnot sit. Bearing down from small of the back, as if menses were about to come on. Much eructation of air, accompanied in e. with hiccough. At n., when lying on back, she is threatened with another jftacic of colic like yesterday's, but this goes off on turning quickly on tojidc; only some pinching about navel remains in changed position j thij, however, goes off gradually, after passing a good deal of flatus. Jnd, — She still feels in all her limbs as if suffering from a long illness. No appetite, but return of cheerfulness and interest in surrounding things, and pleasure in her household occupations.

i. The prover could not be persuaded to go on with the trial at ihit time. It was not till 6th April that she would resume the proving. Up to that time she believed that she still felt some S, symptoms, «uch as pain in small of back, disturbed sleep, irregular bowels, occational abdominal sufferings, Sec. She now took before going to bed 10 gr. of 2nd trit., dissolved in about an ounce of distilled water. Th« n. she slept quite quietly, and the subsequent days she did not record the few slight symptoms she experienced, as she did not think

they were owing to the S. gth. — To-day she complained of a peculiar heidache, not easy to describe, accompanied by vertigo, and compelling heito keep quiet, and at its worst to sit still ; she felt relief by shutting her eyes. During d. she became excessively ill-humoured. No notion of bowels, loth. — She had a motion, but it was so hard that ihe could only get rid of it by pressing strongly, whereby anus felt •ore, and evacuation was covered with blood, i ith. — Frequent call to

i'tool J nothing passed but a few drops of dark blood, accompanied by burning in anus. I2th. — A.m. she had dimness of vision j it seemed » if a veil was before eyes; sometimes she saw objects double; she Could hardly see to do needlework, when sewing the sight went away completely. P.m. when walking a clot of blood slipped out of anus. She passed a very restless n. The following m, all her limbs felt as if beaten. All day long her humour was very bad. 13th. — She was *gain affected by the above-described headache and vertigo. To-day she vras obliged to remain constantly seated, in order to keep off the ittacks i they were rather less in the open air. P.m. this vertigo beoune extremely severe ; there was with it nausea, inclination to vomit,

I twisting and turning in stomach, yawning, excessive prostration almost amounting to trembling of limbs, and occasional noises in head and ears. (The vertigo had this peculiarity, that it increased in violence on stooping or moving about, but was alleviated by sitting still.) The following d. menses came on, at the proper time, but with bearing-down pains from small of back into pelvis, which had never occurred before. They lasted the usual time ; no alteration was perceptible in quantity ^^vrquiUiy. There remained, for a longtime afterwards, derangements ^■pf the evacuations, a» regards both the time of their occurrence and ^^hcir appearance ; they were always hard and lumpy, and often accom-

panted by burning in the anus. In other respects no more symptoms remained from this trial. [Ibid.)

1. Dr. N — ,27 years ofage, of sanguine temperament, made a series of provings with the tinct. 21st July, 1846, at 6 a.m., he took 3 dr. Immediately afterwards slight scraping in fauces, making him hawk ; this lasted about an h. 22nd, — 5 dr. The scraping returned immediately ; it alternated with a drawing pain in r. shoulder, which went ofF by rubbing, 23rd. — Same dose and same symptoms as yesterday. 24th. — 10 dr. Distension of abdomen, rumbling in bowels. In e. 2 liquid stools, with relief to distension. 25th. — 10 dr. No discomfort in abdomen ; no motion. At n. restless sleep; frequent waking from disagreeable anxious dreams. 26th. — In m., after getting up, bruised feeling over whole body ; a.m., drawing downwards on inside of 1. thigh. No stool. 27th and 28th. — No medicine, no symptoms. 2gth. — 10 dr. Immediately after taking them disagreeable tension in abdomen ; no appetite for dinner. In c. 2 liquid evacuations, causing relief to tension. 30th and 31st. — 5 dr. The abdominal symptoms did not return ; only a flying drawing and tearing in 1. shoulder reminded the provcr occasionally that he had taken S. " I now," writes N — , ^^ continued the proving by taking 5 dr. of tinct. daily, but until 6th August I only felt increased lassitude, sleepiness, and tendency 10 perspire on the least exertion. I sometimes felt so exhausted in e. ih I fell asleep sitting on a chair, though people were talking loudly round me." 7th Aug. — In m. 10 dr. In e., without any previoui rigor, violent febrile heat, quickened pulse, confusion of head, and such great lassitude that he had to go to bed. He slept but little during n. ; tossed restlessly about in bed, and had many anxious dreams. 8th. — Bruised feeling all over body ; yellow complexion. 1 0th. — In c. 5 dr. Immediately afterwards violent drawing in 1. upper arm, extending from shoulder to elbow, and lasting an h. In c. troublesome tension m abdomen, followed by a diarrhoeic evacuation, 12th. — In m., on waking, 1. eyelids stuck together ; lachrymation from both eyes ; and along with these symptoms so much photophobia that he could not look towards window. On looking into mirror, after getting up, he found I. eyelid swelled and conjunctivae of both eyes red. In course of d. he had feeling of dryness and heat in both eyes ; on opening and shutting eyes he felt as if lids rubbed against eyeball. 13th. — In m. 1. eye was again closed up, lids reddened, photophobia worse than yesterday \ conjunctiva and sclerotic of both eyes much injected ; least light caused a copious flow of tears. The inflammation of the eyes lasted, in the same intensity, until 20th, during which time 5 dr. of tinct. were taken daily. The appearance grew daily worse, and during all the time he had great lassitude, tendency to perspiration, and drowsiness, 2ist. — The ophthalmic affection declined ; he could look at the light better ; the redness and heat of eyes were less. Some pimples appeared on shoulders and forehead. 22nd. — In m. heat and redness of eyes were greater than yesterday, but they declined in course of d. ; in their stead the disagreeable tension in abdomen recurred, it was only alleviated by 2 diarrhoeic motions. From 23rd to 26th, each d., in m., feeling of heat in eyes and some photophobia, symptoms which regu

'4

A

laHf declined towards latter part of d. In e., although he felt no pain

in eyes, he could not read long by lamp-light without fatigue and

wueting of them. The general health was much as usual. The dis-

poudon was variable, but on the whole rather inclined to be dull and

hchrymose. 27th. — In m. 5 dr. About 7 p.m. violent febrile rigor,

witliout shuddering or thirst, which lasted ^ h., although he went to

bed and covered himself with the bedclothes. This was followed by

great heat, which lasted i^ h., with full rapid pulse. Along with the

Itbrilc heat there occurred disagreeable aching pain in forehead and

gfMt restlessness, which went off when sweat broke out. After this he

y asleep and passed a quiet n., without dreaming or waking, which

Wnot been the case for a long time. 28th — 31st, — Without medi-

|Bne. The derangement of general health continued. On 31st, in

fm., there appeared on 1. cheek, near aia nasi, a small red spot^ which

attained the size of a lentil, ist Sept. — 5 dr. On awaking in m. he

remembered that in a half-sleeping state he had scratched away at his

■I. check, owing to itching there. About 20 elevations, the size of

^ millet -seeds, were to be seen there ; they itched slightly when touched,

ird became more visible after dinner, when cheek was also somewhat

redder and hotter, and. — 5 dr. Eruption on 1. cheek has increased in

extent, especially near ala nasi. Traces of a similar eruption were also

mibic on f. check. After dinner, and in e. after taking a little wine,

eruption became remarkably increased, 3rd. — 5 dr. " Last n.," writes

■ N., "1 again scratched myself violently (during d. I abstained from

■ Kfiiching for fear of making eruption raw). On looking at eruption in m. with a lens, I found, on spots first formed, epidermis coming off injinall scales. I removed one of them on the point of a penknife, »nd found it was of circular form, scarcely above a line in diameter, thickened towards edges, and in centre thin and transparent. Skin iKneath the detached scale was elevated, red, and sensitive." After dinner, the same aggravation of the eruption as on previous d. 4th. — 5 dr. Desquamation appeared on several of the spots ; on r. cheek tniption is extending. "The following days," writes N — , "eruption rcmiined the same, but I noticed with disgust that new scales con- •tjoily appeared on those spots that had already desquamated. One of my colleagues, who had paid great attention to skin diseases, declared the eruption to be a seborihceacongestiva, and prescribed cold douches for it. As I had, at that time, particular objections to an nuption on my face, I discontinued the use of the S., but in spite of that the efflorescence lasted, in greater or less intensity, throughout Oct. and Nov., and was always remarkably aggravated after taking even fery small quantities of alcoholic liquors. The eruption subsequently went away without anything being done for it," {Ibid.)

1. a. SiGMOND Reiss, army surgeon, 20th Nov., 1845, in m. took 10 gr. of powdered S, Beyond feeling of fulness in stomach and eructations of air, nothing worthy of observation. 21st. — Same dose ai yesterday. In e. shooting pains in 1. hip, which extend to upper third of thigh, are worse when at rest, and are relieved by motion and by pressure. General lassitude, confusion of head, and intolerance of aoMC. From 22nd Nov. to 9th Dec. he took daily about an h. before

bis breakfast of milk 20 gr. 23rd. — After dinner pressure in stomach ; frequent eructation of air during d. ; in e. great lassitude and some confusion of head. 24th. — General feeling of illness; great sensitiveness to every breath of air; about 2 p.m. he was so tired he must lie down; he fell asleep, but his sleep was disturbed by confused dreams. Ot awaking an h. afterwards, violent pain in forehead, alleviated in after sneezing several times. 25th. — About 3 p.m. recurrence of severe pain in forehead, with considerable congestion of face and coldness of extremities. Later in d, frequent sneezing, which always gave relief to head. In e. itching in anus ; general lassitude. 26th. — At 8 p.m. pressive frontal headache with flying shoots in 1. orbit. 27th. — During d. colicky pains in abdomen, which became particularly bad at n. in bed until relieved by discharge of flatus. At n. before falling asleep shooting in r. hip, 1. shoulder, and both thighs ; disagreeable feeling of lassitude, as if he had ridden or swum a great deal. 28th. — About 7 p.m. aching in forehead. Before going to sleep colicky pains in abdomen and shooting in I. chest. 29th. — In m., on awaking, itching in r. hand, especially betwixt fingers. P.m., rumbling and griping in bowels, with relief by discharge of very fetid flatus, accompanied by feeling as if a loose motion were being passed. In e. two loose stools. 30th. — Immediately after taking medicine, gripings in belly, which frequently return during d., with feeling as if diarrhcra were about to ensue, and then with fruitless call to stool. "It is remarkable," writes R — , "that from the commencement of this proving I have awaked every m. at 5 a.m., and have been unable to fall asleep again, a thing that never happened to mc before." ist and 2nd Dec, -—Same symptoms as on the 30th Nov. 3rd. — Frequent fruitless call to stool. P.m., frequent violent sneezing. Towards e. sudden shoots in orifice of urethra. At n. a remarkable quantity of urine passed. 4lh. — P.m., flying shoots in 1, supra-orbital ridge for 5 m. 5th. — In e, severe shooting in r, calf and r. upper arm. For some d. past he has observed a remarkable distraction, and particularly a very great loss of memory with respect to well-known local circumstances. 7th. — Immediately after taking medicine, symptoms in abdomen the same as those that occurred a few d. before, with relief from emission of flatus. Four h. later a loose stool with itching in anus. 8th. — In m., on awaking, sensation as if a worm crept out of anus. Uncommonly late of falling asleep, and early waking in m. (4 a.m.) since 3rd. From 9th to 13th Dec. inclusive, proving was discontinued, but from 14th (with the exception of the 2Sth and 28th) to 30th, 20 gr. were taken daily. loth and nth. — At n. before fallmg asleep, sudden shooting pains in the r. half of head, with glowing hot cheeks and cars. At n. heavy confused dreams. I2th. — No symptoms. 13th. — On awaking from afternoon nap sensation as if hair were in throat, but without difficulty of swallowing. i4th. — At n., before falling asleep, for a i h. shooting pain in 1. forehead, extending to occiput^ and relieved by external pressure. 15th. — In m., after awaking, shooting betwixt and and 5th I. ribs. Immediately after swallowing the S., eructation of wind, and the usual abdominal symptoms. At n. before falling asleep, itching all over body, headache as yesterday, but much milder, and

ilight shooting in chest as in m. i6th. — After constipation had continued for 2 d. a copious loose motion, with burning in anus, i 7th. — lae. violent pain, as if head were screwed together from without, with Sjingheat in face. At n, shooting in r. forehead, extending to orbir. iSth. — Immediately after taking medicine same abdominal symptoms IS jbove described. At n., in bed, flying shooting in r. ribs, extending to the shoulder. "Since 15th," he observes, "I have awaked every a. It 4 o'clock, and have been unable to fall asleep again." 19th. — Tvob. after taking medicine aching in stomach, which lasted ^ h., and fu conjoined with disagreeable feeling of repletion. For the first time fori week head is free from pain. 20th. — In m., i h. after taking medicine, burning in fauces ; after i ^ h., on stooping and raising up the body, bruised pain in small of back, which recurs several limes during <i. At n., in bed, icy coldness of feet. 2lst. — At n. before falling islcep, icy coldness of feet, with glowing heat in head and hands ; violent stupefying headache and shooting in 1. chest, lasting more th]n ^ h. He tossed about uneasily in bed, and could not help thinking he was going to be seriously ill. 22nd. — A vesicle on I, border of tongue. A.m., flying stitches in 1. chest, increased by walkj quickly and going upstairs. 23rd. — Traces of the stitches in chest of yesterday, but only when walking. In e., the bowels, which had been constipated for 2 d., were opened unsatisfactorily. Before falling ^ccp, flying shoots in 1. ribs. 24th, — About 4 a.m. aching pains in region of r. sacro-iliac symphysis, and in r. shoulder. A.m., shoots in f. Icnce-joint when standing. In e. shooting in r. ribs. 25th. — A.m., on 'iiDpinng cold air, tearing pain in a loose healthy incisor tooth. 26th. —During d. dull headache. At n., before failing asleep, shooting in 1. ibigb, in direction of crural nerve, for more than \ h, 27th, — In m., 00 awaking, pain in 1. thigh recurred more violently than on preceding

In.^it was conjoined with great weakness almost approaching to para- 'pis, but was relieved by getting up, and went off in course of d. r.m., stupefying headache. At n. traces of pain in thigh. 28th. — Shooting pains in r. knee-joint, especially when standing. At n. again traces uf pain in thigh. 29th, — After taking medicine, the well-known •ymptoms in abdomen. During d. shooting pains in 1. hip-joint and in ball of 1. hand. 30th. — During d. feeling of weakness and dislocation of r. wrist. At n. feeling of great weakness of 1. leg, and shooting pins in 1. hip-joint. 31st. — In e. bruised pain in small of back.

i. Of the 31X dil. he took on 8th Jan., 1846, before going to bed, Jo dr., without any result, igth. — In e. 2 scruples of same dil, ^B (After this he took no more.) Immediately after, metallic taste in ^Bnouth like copper. Before going to sleep shooting pains in upper H^border of 1. orbit. 20th. — In m. great itching in anus. In e., before Agoing to sleep, sudden shoots in 1. thigh, in course of crural nerve, relieved by walking. At n. sudden shooting in middle joint of r. little K^nger ; ^ h. afterwards numbed feeling and great lassitude in 1. ankle- ^BtKOt. list. — About noon, bowels having been constipated for 2 d., ^Kttitless call to stool. At n., before going to sleep, aching squeezing fEains in I. ankle, which, after lasting a short time, give place to shoot- ** ing pains in I. sole. 22nd. — In m., on awaking, confusion of head,

»

t

which went off after discharge of flatulence and going into open ^^' About noon, feeling of fulness in stomach and violent hiccup, last ' "S \ h. P.m., after violent straining and cutting in anus, a scar^^^' evacuation, and afterwards sensation as if mucous membrane of recti^ ^ were pressed out. About 6 p.m. flying shoots in vesical region, vf^ feeling of soreness on pressing on it. Before going to sleep cramf^^^y pain in lower third of 1. thigh, and disagreeable feeling of lassitud ^• 23rd. — About 4 p.m. excessively violent pains in small of back, conr^peliing him to go to bed. At n. very restless sleep. Zifth. — In nf^great weariness. During d. he felt quite well. 25th.' — No symptom:^s- 26th. — About if p.m. violent aching pains in frontal region, which h» < ascribed to the constipation that had already lasted 3 d., whereupon \m. < took a cold water enema. This produced an evacuation, but had ik ^ effect on the headache. About 2 a.m. there occurred by iits drawin ^ pains in lower third of thigh, and feeling of tension in 1. parietal boni^^ as if skin there were too tight and covered with ulcers. 27th, — In in — 1 after awaking, tearing pains in 1. shoulder-joint. 28th. — At n.,bcfor^ falling asleep, shooting in 1. hip-joint. [Ibid.)

1. a. Dr. RiEDtlNGER, 27 years old, of sanguine temperament > has always enjoyed good health. He took i dr. of tinct. mixed wit 1^ an oz. of water every m. from 8th Aug. to 3rd Sept. inclusive. Tb. ^ following effects were observed: 8th. — Hoarseness; rumbling an *d

pains in abdomen ; night's rest disturbed by vivid dreams. 9th.

Great lassitude after walking. Headache ; shooting in anus. lOth.

In m. hoarseness; urgent call to stool, two loose motions, llth.

Very great lassitude; pains in abdomen; towards e. tiresome long"" continued burning and itching over right ankle; atn. many disturbing dreams. 12th. — Great sensitiveness to every breath of air ; frequen.K urgent call to stool ; appearance of a small boil on 1. shoulder, 1 jth.— — Uncommon lassitude ; heaviness of and burning in feet j colicky pains- 14th. — P'ormaiion of an erythematous patch, size of palm, on outside of leg, which, especially at n. in bed, itches constantly, compelling him to scratch, but afterwards is very sore. 15th. — Dyspnoea when walking quickly ; weakness of chest on reading aloud ; pains in abdomen ; two loose motions. i6th. — In e. hoarseness ; pains in small of back; itching in anus ; erythema continues ; at n. vivid, disturbing dreams. 17th. — Great prostration; low spirits; urgent call to stool, two evacuations. i8th. — Fains in abdomen with every draught of air; tendency to perspiration, especially in face ; erythema continues, 19th. — Looks ill; emaciation; falling out of hair; marked loss of sexual power ; sleep disturbed by dreams. 20th. — Great lassitude ; voracious hunger ; feeling of weakness in chest j frequent call to stool ; frequent emission of flatus smelling of rotten eggs; two motions; erythema continues. 21st. — Uncommon cheerfulness ; very importunate sexual excitement. 22nd. — Cutting in the bowels after a motion that is at first hard and afterwards soft. Erythema goes ofF, but leaves behind it troublesome smarting in leg, which compelled him to throw the clothes ofi" legs at n., as heat aggravated it. 23rd. — Great lassitude ; rumbling in bowels, two liquid motions. 24th. — Burning in r. eye for a short time, which recurs at short intervals. 25th. — In e. burning in

('«!, After midnight he must get up to pass water ; on doing so he hupjin in front of urethra. a6th, — Itching between fingers ; a loose motion ; p.m. in the open air, without any cause, great depression of ffints. 27th. — In e. severe cold in head with headache ; boring above root of nose ; vision as through a veil ; stoppage of nose ; violent «««ing ; quick pulse j great lassitude and sleepiness, so that he could not help falling asleep. aSih. — The cold in head continues j great liuitude j drawing pains in shoulder} a hard motion. 29th. — In e., immediately after taking medicine, flow of water into mouth ; rumbling in bowels, and in an h. afterwards a loose motion. The coryza con- ' tinuts. 30th. — Shooting above 1. eye ; small dark specks before eyes ; cja dazzled after looking long at an object. Coryza continues. 315L— Coryza diminished j toothache and inflammatory swelling of gmn in vicinity of a stump almost entirely destroyed, ist Sept. — Continued weariness ; heaviness of legs in bed in e. ; stiffness and weight in bees, especially on rising from his seat ; the weariness goes off on walking about for some time in open air. 2nd. — Great anxiety in cltKt ; frequent attacks of hoarseness ; shooting in I. chest, then loose motion. 3rd. — Great burning in hands. The itching on legs (especiilly 1.) comes on every e. Pain in corns. At n. (as was the case on several previous nights) a pollution. The next four weeks he left off taking medicine ; the lassitude and drowsiness did not quite go off, but were much less, the spirits better, the coryza and itching on legs coied, and he had a firm evacuation every d. L b. A drop of the tinct. mixed with 3 oz. of water was taken every Hm. from 4th to 22nd Oct. 4th. — Scraping in throat ; violent sneezing; ^ Sying shoots in chest; at n. vivid dreams. 5th. — Great lassitude and "Irowsincss by d. j burning in hands ; two loose stools. 6th. — Great Ktinitude; submaxillary gland somewhat swollen; tiresome pressing Bud shooting in 1. inguinal region ; at n. vivid dreams. 7th. — Hoarscno$ ; itching in r. leg; coldness of soles; a loose motion. 8th. — Great lassitude ; pressing in the groin continues, and is combined with [t feeling of heat ; burning in hands ; after a glass of beer immediately ftbullition of blood and great sleepiness. 9th. — Drawing pains in r. Itiftia, and frequent prickling in legs; a loose motion. loth, — After 'otitig but little, tiresome feeling of fulness in abdomen ; rumbling and I two loose motions. At n. very vivid dreams ; he felt as if falling from I height, ilth. — In e. confusion of head and pressing in furehead. I2th — Very troublesome lassitude ; constriction of chest and occasional bootings in it ; at n. horrible dreams. 13th. — Shooting pains in teeth ; ainful swal lowing ; two loose motions. 14th. — Weariness; burning in hands; in c. great itching on legs. 15th, — Swelling of 1. sub- ^Baxillary gland ; itching in eyelids and burning in eyes ; burning in skin of whole body ; two loose motions. i6th. — Great sensitiveness of upper part of abdomen, so that clothes press disagreeably, though ■ ey arc not fastened tighter than usual, 17th, — Easy bleeding of ims ; at noon, disgust at meat ; after eating but a little, fulness in ch ; shooting in anus ; a loose stool. i8th. — Weight in head ; ling pain in forehead ; vertigo on stooping ; coryza with very frequent sneezing. 19th. — Great weariness; anxiety in chest ; dyspnoea vol. IV. 14

on walking quickly ; nose much stopped up ; ringing in ears. In e. flying heat ; quick pulse and burning in hands. At n. very vivid dreams. 20th. — Heaviness in head; palpitation of heart without any reason; burning in skin all over back; tension in knees and calves on going upstairs ; two loose motions. In e. sudden sadness and disinclination for everything. 21st. — Hoarseness ; tiresome itching in nose, which is still stuffed ; feeling of heat in back ; sudden pinching in arms ; on walking cramp-like pain in soles, extending to toes. 22nd. — In e. on passing water flying shoots in urethra ; burning in eyes and feet ; on least exertion perspiration in face and nape of neck ; itching on fingers ; dread of catching cold. [Ibid.)

1. Dr. Hermann Schlesincer, healthy, except that for the last 18 months he has been afflicted with a yellow scaly eruption (psoriasis discolor) extending over arms and body, but not causing him the slightest inconvenience, proved S, in substance, in high potencies^ in tincture, and in trituration.

a. From 5th to 14th Feb., 1846, he took daily 5 grains of flowers of S., which produced no particular effect except violent boring pain in a hollow tooth, which on 8th, 9th, and loth always occurred in e., and tormented him until late at n. But as he had no more toothache during whole time of proving, he was disposed to attribute it rather to the wet weather then prevailing than to the S. From 20th to 24th inclusive daily 10 gr. ; with exception of eructations smelling of S. (not of sulphuretted hydrogen) soon after taking it, and costive motions, no symptoms occurred. 25th Feb. — He took 3j ; this was followed by eructations of gas, smelling of S. The appetite, which had been increasing for several d., was uncommonly good to-day. 26th and 27th. — Same dose ; no symptoms. On 2nd March he took 555, and on 3rd 3ij of S. This produced increased appetite, so much so that contrary to custom he must eat at other times than the accustomed meals. Motions not so hard, easily passed. 4th. — 3j. An h. after taking this he ate, with his usual appetite, his usual breakfast, consisting of a cup of coffee and a roll, whereupon there occurred first eructation of wind, then of what he had eaten ; nausea ; and in \ h. vomiting which brought up both breakfast and S. 6th. — Same dose. Except eructations smelling of sulphuretted hydrogen, which occurred in e., no symptoms. 7th. — About 10 a.m., same dose. In 4 ^' rumbling becoming ever louder, and great inflation of belly, so that he had to unbutton his clothes. Appetite was somewhat diminished; soon after eating he had a copious, loose, yellow motion, accompanied by emission of a great deal of flatus smelling of sulphuretted hydrogen. After emptying mingled urine and fxces out of the utensil he found a thin sediment, which proved to be S. 8th. — A.m. dose was repeated. Soon afterwards eructation of wind ; inflation of abdomen, with flatulence. Appetite somewhat diminished, and p.m. he had two and at n. one liquid evacuation mixed with mucous shreds, with burning pain in anus. 9th. — Three more liquid stools, followed by constipation for next 3d. 13th. — A.m., 3ij. During d. felt quite well. In e. pricking pains in umbilical region, which intermitted from time to time, but ilways recurred more severely, and compelled him to draw up legs.

Two h. afterwards sudden urgent call to stool, which could scarcely be complied with quickly enough. Diarrhoea now set in as on the 8th, which lasted with equal severity on following d. ; it declined gradually on 15th, but continued till leth without any repetition of S. The pains in abdomen ceased on occurrence of the diarrhoea, and did not return. The provcr being convinced that S. in substance produced nothing but mechanical irritation of his bowels, and had not the slightest effect on his skin disease, left off his trials for two months.

t. On 2nd, 3rd, 6th, and 8th May, he took 5 dr. of the 403rd dil. On I2th — l6th he took 10 dr. of same dilution without noticing any effect except a slight confusion of head on 13th and 14th, which was probably owing to the spirits of wine. Despairing of obtaining any results from this preparation he ceased taking any more of it.

i". 20ih June. — In m. 5 dr. of the tinct. in a tablespoonful of water. In ^ h., oppression of forehead (as if intoxicated), flow of water into mouth, and uncomfortable anxious feeling in stomach as in nausea. In an h. these symptoms went off with empty eructation, and he felt perfectly well. 21st. — 5 dr. Same symptoms as yesterday, with this difference, that oppression was more on 1. side of forehead. In degree and duration it was same as yesterday. 22nd and 23rd. — 5 dr. No symptoms. 24th to 30th. — 10 dr. daily. 24th. — At noon increased appetite, but soon after eating disagreeable feeling of fulness in stomach, lasting 4 h. ; afterwards, when walking in the open air, sour eructation. Towards e. crampy pain in lumbar and sacral vertebrae, which impeded every motion of body, lasted until bedtime in same intensity, and went off during n. The pain was not increased on pressure. 25th. — At noon uncommon appetite, which, however, he did not satisfy, but left table before he was satiated ; by so doing he escaped the sufferings of yesterday. No stool ; towards e. same crampy pain in vertebrz as yesterday. Sleep disturbed ; waking up at 4 a.m., and inability to fall asleep again, which had never before happened. 26th. — The cramp pain had again gone off during n., but there remained a stiffness in spine which made it difficult to lean forward and compelled him to stretch out body frequently. Appetite remained as good as before for dinner and supper ; p.m., after great straining, an evacuation. In e. again crampy pain in lumbar and sacral regions, which went off in bed after occurrence of violent itching in rectum. At n. he slept quite tranquilly, but again awoke at 4 a.m., was quite wide awake, and did not agam fall asleep. 27th. — In m. on changing his linen he observed that his skin desquamated more, or at least mure easily than usual, so that a mere gentle stroking with the flat hand sufficed to separate large quantities of small loose scales from the morbid skin. He observed the same thing in the scalp, whence clouds of small scales could be brushed. No change was observable in the eruption. The stiffness of back which was present to-day was less tiresome than the d. before ; the crampy pain was quite gone. Appetite was rather increased than diminished, and he relished breakfast, dinner, and supper amazingly. Spirits, too, were better than usual, he was more disposed for literary work than he had lately been. No stool. N. quiet, but he woke as

usual at 4 a.m. and remained awake. 28th. — The scales fell ftxtni head' and morbidly affected skin in smaller quantity than on previous d., but they were still more plentiful than usual. Appetite, spirits and pleasure in work were same as yesterday; but latter were much diminished towards e. by recurrence of sacro-lumbar crampy pain, fiowcls were not moved. In course of d. and in e. itching in rectum, which, however, never lasts longer than a m. He fell asleep about 9.30 (nearly 2 h. sooner than usual), slept quietly and uninterruptedly, but woke up as usual at 4 a.m. 29th. — Still no stool ; occasional tickling in rectum. The cramp pain came on at noon and lasted till late at n. Appetite and spirits diminished in proportion as they were previously increased. He went to bed at midnight, soon fell asleep, and slept quietly, but again awoke soon after 4 a.m., and remained awake. 30th. — In m. soon after taking medicine went into country and walked 2^ h., when itching in rectum occurred more frequently and lasted longer. After dinner, which was taken with considerable appetite, he had call to stool, and at last after much effort an evacuation, whereupon itching in rectum ceased. In e. moderate crampy pain which lasted until he fell asleep (at midnight). Sleep quiet and uninterrupted until 4 a.m. precisely, when he awoke, but after lying wide awake for \ h. again fell asleep until near 7 a.m. ist July. — Still in the country, he took none of the medicine. He walked for 3 h. with the greatest comfort. During d. he had nothing to complain of, except that bowels were not moved, and in e. he had a moderate amount of tension in sacrum. The night's rest was frequently disturbed, and he slept no more after 4 a.m. On 2nd — 8th he took every e. 20 dr. in half a tumblerful of water, 2nd. — The scales on head in great numbers. Whilst taking a warm bath he noticed surface of water speedily covered with fine scales ; on former occasions when taking a bath scales were much fewer in number, were in larger flakes, and only appeared after usine soap. The patches of eruption appeared less red after the bath than usual. Appetite again much increased, spirits uncommonly good. After the bath bowels were moved ; tension in sacrum did not recur. N. quiet ; heawokeat 4.15 a.m., but afterwards fell aslccpfor ^h. longer. 3rd, — P,m,, in outer canthus of I. eye slight tickling, which gradually increased to considerable itching^ which compelled him to rub eye, and made all work in e. impossible. He attributed this to a glass of wine he had drunk at dinner contrary to custom. No stool. Sleep twice interrupted, and each time itching in eye was present. He awoke in m. at his usual time, viz. about 6. 4th. — Scales on head were less numerous this m. when he brushed his hair ; but they became much more abundant during d., and were in form of fine dust. On patches of eruption on body no loosening of cuticle was perceptible, as was formerly the case during first fewd. after taking a bath. No itching in 1. eye a.m. He took no wine at dinner, which he ate with the best appetite. About 4 p.m. tickling in outer canthus of I. eye, and soon afterwards itching in it so violent as to cause him to rub it. In e. by candlelight itching extended to inner canthus and changed into shooting pain. He had a motion with great effort, unaccompanied by pain in rectum. On account of constant shooting in eye it was mid-

J

niglit before he fell asleep, and not until he had allayed the pain by flicanj of cold compresses. N. was tranquil j he awoke about 6. jfh. — Itching in external canthus of 1. eye recurred soon after walking in open air, it compelled him to close eye repeatedly, and then cccuntd a considerable flow of tears. With some intervals this state luied all d., and was worse during candlelight^ but without such ««erc pains as the d. before ; and it did not keep him awake at night. No stool. 6th. — In m. affected eyelid was covered with a dry cake of mucus. Upper lid felt stiffen first opening eyes; otherwise nothing morbid was visible. On going out eyes watered for a short time, but there was very little itching in 1. eye. 7th and 8th. — No symptoms acept slight adhesion of lids at I. external canthus. loth. — 40 dr, oftinct. in half a tumblerful of water daily till 17th. All d. he felt quite wclJ. At n. uncommonly profuse perspiration over whole body without any bad smell. After awaking at 5,15 a.m. and drying body he noticed that patches of eruption were paler, not so dry 0( wrinkled as usual ; the scales, too, which were partly detached, wfre in smaller quantities. L. eye still somewhat closed up with mucus; upper lid less stiff, nth. — In course of d., without any cause, very melancholy disposition, discontent with himself and all >bout him, which made him unfit for any serious occupation and at same time very irascible. Still appetite was good, and on satisfying it liii cheerfulness returned, but only for a short time; for during whole e. he was absorbed in himself and unable to command his thoughts to fttd, so much so that he sat staring at same page for upwards of 2 h. Atn. he had again perspiration like previous n,,and in m. he observed 1^ that scales on head were diminished very much, 12th. — His spirits, H thjch were as usual in m., underwent a change about noon ; but it was " Jos sadness than irritability which now affected him. Inc. uncommon hunger ; on satisfying his appetite, and contrary to custom drinking a couple of glasses of beer, he became so overcome with sopor that he had (ogotobed. 13th. — With exception of some flying shoots in 1. side of cbejt (judging by sensation, in intercostal muscles} which occurred when walking, and once when speaking, and compelled him to hold his breath for an instant, he felt no effects from medicine. At n. profuse Sweat again. 14th.— Of the smaller scattered eruptive spots, several, especially those on 1. arm, were completely gone, and on larger patches were to be seen here and there little islands of healthy skin. The L other eruptive spots were still coloured like liver-marks, wrinkled, ■ slightly elevated ; but they scaled less, and felt less rough. On the ^■I5th, i6th, and 17th his bowels were moved every other d. without Bcffort, and the motion was moderately firm ; which was very different ^from what took place on commencing to prove tinct. The eruption continued to make slight but perceptible progress to amendment, by the increase of number and size of healthy islands on morbid skin. 20th, aznd, 23rd, and 24th. — 60 dr. in 4 oz. of water. As no effect was perceived from these doses he left off taking the tincture, thinking that be had lost his susceptibility to its action. From 27th July the bowels were moved regularly every d., so that in this respect the medicine exhibited no secondary action. But this was not the case

with respect to the early waking, for on 2<)ih, 30th, and 31st July, also on 5th and 6th August, although he did not go to bed earlier than usual (on 5th August not till i a.m.), he became quite wide awake exactly as the clock struck 4, and only on two of these n. could he again fall asleep. " But," says S., " the most agreeable thing for me was to see my eruption disappearing from that time. This took place not by a gradual and uniform return of the morbid skin to the normal state, but by the increase and extension of many healthy points (hairfollicles) among the still morbid patches, whereby the latter were separated into many smaller groups, and were at last limited to a few spots the size of hemp-seed or lentils — corresponding to single hair follicles — which by the end of September were quite gone from the arms and chest. There still remained some groups on the belly and back, and in the months of August and September some new eruption spots appeared on the legs, which had hitherto remained free excepting a small spot on the r. calf. Subsequently, however, these new spots disappeared unobserved by me."

d. On 3rd — 6th Oct, he took daily 5 gr. of 6x trit., without any perceptible effect ; also after 10 gr, which he took on 7th and 8th, he noticed nothing. On loth and iith he took 5 gr. of the 3X. The first day no symptoms occurred ; the second, however, was more fruitful. In e. by candlelight he had recurrence of itching in external canthus of 1. eye. At same time upjwr lid itched (after 5 — 10 m.) to such a degree that he must involuntarily rub the eye. This he did so

gently that it could not have caused the symptoms that followed, tching increased in course of e. to burning ; lids winked frequently and light hurt eye. The following n. was quiet, in m, he awoke with stiflF eyelids, which, however, soon regained their ordinary mobility. Lids and caruncula were both injected of a bright red colour. 12th. — Same dose. During d. eye was pretty well, with exception of redness above described, and occasional itching on lid-borders, as if they were covered with crusts that ought to be removed. But on approach of n. and at sight of candles, edges of 1. eyelids commenced to burn, and photophobia came on. On reading or writing eye watered, and pain increased, preventing him going on with his work. 13th. — No medicine. In m. on awaking he could not open eye immediately on account of stiffness of lids ; he only succeeded in doing so after several trials, and then there appeared a considerable quantity of mucus, which obscured sight, and in spite of frequent wiping away continued to return. This secretion of mucus lasted the first 2 or 3 h. of forenoon, and did not cease till about noon. In c. again itching, then burning pain followed by photophobia and flow of tears. From 14th to 25th inclusive he took daily 5 gr. of same trit., and during all that time the blepharo-blennorrhoea of 1. eye just described persisted. F>om 26th he ceased taking the S., and by 30th the eye affection was quite gone ; but on 2nd Nov. he took a similar dose, and in e. the ophthalmic affection returned with precisely the same symptoms. On 8th r. eye was affected in a similar though a slighter manner. "On the 15th Nov.," he writes, " I had had quite enough of my proving and my eye disease, which bored me by preventing me doing anything in e. ;

wlleft off", ajid by the 25th my eyes were quite well. The remains of the eruption were not perceptibly affected by the trits." (/W.)

1. ScHWEiKOFER, surgeoH, £et. 41, of phlegmatic-sanguine tempeiMent, suffered from itch when a boy, which was got rid of by inunctii);i$ of sulphur and mercurial ointment. When 17 he had scarlatina, which left a great tendency to sore throats, so that in cold^ damp, and foggy weather, or after getting wet, he is very often affected with inH^mmation of tonsils and palate, for which he has usually employed letches, caJomelj &c., in accordance with the principles of so-called fJlional medicine. As a consequence of the frequent attacks of inflammation, there occurred considerable enlargement and induration of tonsils, followed by elongation of uvula, which on account of the discomfort it caused him had to be partially removed. This tendency to sore throats lasted till 1 841, at which time he became acquainted with homoeopathy, and used belladonna for his cure, and ever after that remained exempt from attacks.

a. His provings were made exclusively with dilutions of Sulphur, ■ which be prepared himself according to the centesimal scale. He took B of the 400th dil.,on ist July, 1846, 10 dr. ; on 4th, 50 dr. ; and on 9th, " 100 dr. No symptoms. On 10th, about 10 a.m., 10 dr. of 200th. Twoh. afterwards shooting in r. side of chest, which tasted till dinnertime, nth. — No medicine. In m., after awaking, itching in eyelids, 'ith. — About 9 a.m., 50 dr. In m., after awaking, itching in eyelids, which are gummed together; white of eye is reddened. On back of r. hand 2 small pimples, which he must scratch; itching and smarting l>etwixt fingers. 13th. — About g a.m., 100 dr. Itching on lids much diminished ; redness of conjunctiva less ; pimples on hand, which burst when scratched, excreting a clear transparent fluid ; itching and smarting between fingers not troublesome. i6th. — About 9 a.m., 10 dr. of 'ooth. No symptoms. 17th. — At 9 a.m., 50 dr. Sensation as if 'nflimmation in eye was about to come on. i8th. — No medicine. In 0' on awakmg prickling, causing him to scratch, itching, and smarting ID lids; loose motion, with tenesmus. In course of d. 3 diarrhceic «Oob. igth. — At usual h. 100 dr. Same disagreeable feeling in eyelids as yesterday, 20th. — No medicine. Itching and smarting in lids Ouch diminished i towards e. it went off completely. 21st. — No medicine. In m. in bed tearing and shooting pains in I. shoulder, and violent tearing in r. upper arm. After getting up and walking about in open air, pains went off. 22nd, 23rd, and 24th. — No medicine. Eich d. a soft motion ; otherwise perfectly well. 25th. — At 9 a.m., JO dr. of 60th, In 2 h. urgent call to stool, and loose motion. 26th, —50 dr. In a few m. motion of bowels, though previously he had felt no call ; itching in r. eye. 27th. — 100 dr. During d. prickling, Itching, and smarting in eyelids. At n. vivid dreams of comic character, with loud laughter, which continued for some time after awaking. 28th. — No medicine. In m. after awaking eyelids gummed together, and feeling as if fine sand was in eyes ; flying shoots in walls of chest, first on r., then on I. side, and finally on r. side of abdomen. Soft insufficient stool. Bad spirits. 29th. — No medicine. No symptoms. 30th. — At 9 a.m., 10 dr. of 30th. In 2 h. sensation of prickling in

ai6

both eyelids, causing him to scratch and rub them ; sensitiveness light. 31st. — At 9 a.m., 50 dr. About 3 p.m. feeling of fine saj betwixt r. eye and lid. ist Aug. — 100 dr. No symptoms. 2nd. — . No medicine. Itching and burning of eyes ; itching and smarti i betwixt lingers of r. hand, on back of which appeared a scabious*loolci n pimple, which went off in e, ; shooting in chest externally. 3rd. — 1># medicine. In m. itching and smarting in both eyelids ; copious seci tion of mucus from Meibomian glands ; sensitiveness of eyes to day^ light; fine sudden shoots on outside of 1. heel-bone; sore feelin_ burning and smarting on glans and inner surface of prepuce, whicli parts are somewhat reddened. 4th. — No medicine. On glans znef prepuce same symptoms as yesterday, and in addition a small pimple on glans. Respecting his sensations from 5th to 28th Aug., during which lime he took no medicine, he says : " The itching and smarting on prepuce and glans continued to increase ; it is with the greatest difficulty I can refrain from scratching and rubbing; pimple on glans is gone. During this time skin of prepuce desquamated ; inflammation extended along whole penis to pubes ; the itching and smarting vu very violent and tiresome. The desquamation of the epidermis, which recurred every 6 or 7 d., lasted several months, and only went off entirely at the beginning of November."

h. 15th Nov. — At 9 a.m., 10 dr. of 20th ; on 19th, 50 dr., and I d. later 100 dr. No symptoms. The 15th and 12th dils. were taken in a similar manner, without effect. 8th Dec. — 5 dr. of 6th. No symptoms, ilth, — 50 dr. In m. after awaking itching and smarting all over body, but especially on eyelids, foreskin, glans, and legs. In e. violent pains in occiput. Night's rest disturbed by many vivid dreams. 12th. — No medicine. Yesterday's symptoms recurred to-day, but in slighter degree. 13th. — 100 dr. No symptoms. He was prevented going on with his trials in consequence of becoming ill from taking cold. (Ibid,)

1. Adolphus 5EYDL, medical student, proved S. in substance and in tincture.

a. From i$th to 24th Aug., 1846, he took daily (with exception of 22nd)j about 7 a.m., as much as would lie on the point of a knife of flowers of S. ; and from 29th Aug. to 5th Sept. daily (with exception of the 26th Aug.), at 7 a.m., a teaspoonfnl of same substance. 15th. — Throughout forenoon eructations smelling of S. ; no other symptoms. i6th. — Same. 17th. — Sulphurous eructations; no stool. l8th. — Same as yesterday. 19th. — In m. sulphurous eructations; p.m., heat of whole body ; perspiration in axillae and palms. Ln e. a hard evacuation. 20th and 21st. — Sulphurous eructations ; no other symptoms. it3rd. — A.m., sulphurous eructations ; p.m., great heat in whole body, with much sweat in axilla: and palms ; no stool ; at n profuse sweat and restless sleep. 24th. — Same as yesterday, 25th.— Very troublesome sulphurous eruct.uions. In e. a firm motion. 28th. — Drawing in small of back, especially when sitting, lasting all d. 29th. — Drawing in back recurred, but much more mildly, ist Sept. — No stool. No other symptom. 2nd. — No stool ; towards e. very violent drawing in small of back ; at n. heat and considerable pers

{""■^a-tion. 3rd.— Anorexia. No stool. The next 2 d. no syra»

^. From 15th to 26th Oct. he took daily, at 7. 30 a.m., 10 dr. of "•^^t. in half a pint of water. i8th. — Tiresome feeling, as if bruised, " ^' mall of back ; slight trembling of hands and great trembling of r. ''^ «nb ; at n. heat of body much increased. 20th. — At ii| a.m., ssional violent shooting in r. cheek-bone. 24tb. — Itching in fingers ; ^^S J»t redness of fingers, which disappeared on pressure, but returned '^ *~»iediately that was removed. 25th, — In m. he noticed on inner ^ ^ace of r. ring and little fingers some white painless vesicles, size of ' l::V)ppy-seed, which were partly in groups, partly isolated. 26tb. — ' "^^'o vesicles close together on inner surface of 2nd joint of r. middle

c. On 27th Oct. and two following d. he took each m. as much

^^^wers of S. as would lie on the point of a knife in half a pint of

'^atcr. 27th. — Sulphurous eructations. No other symptoms. 28th.

— -No stool ; at n. drawing in small of back. 29th. — The drawing in

^tnall of back lasted all d. and throughout following n. ; on r. ring

finger some more vesicles appeared. {Ibid.)

3a. Dr. Sterz, of Trieste, made four trials of S.

a. On 1st Feb., 1846, at 6^ a.m., he took 100 dr. of 30ih dil. j* the two following d, 200 dr., and on 8th and 9th 300 dr., without any effect. From 25th Feb. to 2nd March inclusive he took daily at noon, 2 h. before dinner, 300 dr. of 20th. No symptoms. On 5th, 6lh, lOth, nth, 14th, and l6th March, at noon, 300 dr. of 15th. After last two doses slight and transient burning in anus after moderate exercise. On 18th, 20th, 21st, 24th, 25th, and 27th, at noon, 300 dr. of loth. No symptoms. From 29th March to 3rd April inclusive, at noon 300 dr. of 6th. After third dose occurred persistent burning in external canthus of r. eye, and at same time sensation as if a grain of sand was in it. Eye was not reddened.

b. The 3rd trit. taken in doses of 20 gr. on 6th April, 30 gr. on 7th, 40 gr. on 8th, and 60 gr. on 9th, had no effect. After 2nd trit., which he took in dose of 50 gr. on 4th, 5th, 7th, 9th, and I ith May, the following symptoms appeared : 5th. — In m. soft stool, with emission of much flatus having smell of rotten eggs ; an h. after taking medicine rumbling in bowels; frequent eructation, with odour of S. ; feeling of emptiness in stomach. 6th. — Soft stool in m. 9th. — Two h. after dose some stitches in anus. loth. — Occasionally in course of d. stitches in anus. nth. — At n., when going to sleep, lightning-like flashes before eyes.

f. On 6th June 10 dr. of tinct. in two tablespoonfuls of water; soon after taking it, several eructations smelling of S. 7th. — 15 dr. In m. knotty stool ; after taking medicine frequent eructations ; an h. afterwards pricking in abdomen lasting but a short time, 8th. — ■ ao dr. Soft stool, with itching in perineum. 9th. — No medicine. Jtching and shooting in anus and perinaeum ; drawing in r. thigh, in r. shoulder, and up nape; soft stool. lOth. — 25 dr. Sulphurous eructations •■, drawing pain on r. side of nape ; itching in anus, i ith. * Both dils, and trits. were on centesimal scale.

2l8

— No medicine. Stool pretty firm, and covered with mucus. Wh at stoo! aching pain in small of back. Drawing up nape. I2th. — i dr. Sulphurous eructations as usual immediately after taking dry Eruption of several small, inflamed, not itching, pimples on foi — middle, and ring fingers of 1. hand. Itching in anus. 13th.' — 35 A In m. on awaking paralytic feeling in r. arm, lasting an h. St< formed and covered with mucus ; it slipped quickly through aniK P.m., frequent paralysed feeling in r. elbow-joint. 14th. — No metl. cine. In m. expectoration of salt-tasted saliva ; soft stool. On ind^ and middle fingers of r. hand, some small pimples. The expectoratic:» of salt saliva early in forenoon after hawking and slight coughir« went off in 4 d., during which time the inflamed pimples dried up.

d. He took on nth, 12th, I4th^ i6th, i8th, 21st, and 23rd Jul at 6 p.m., 2 gr. of S. rubbed up with 20 gr. of milk sugar, each ti freshly prepared, nth. — Five m. after taking it, several eructatio smelling strongly of S. 12th, — In m. on making water many fix^ stitches (as with needles) in region of neck of bladder, and seveK~^ more violent stitches through anus. Stool as usual, only it was evr^ cuated more rapidly than usual. After stool slight burning in ani-a^ lasting some m. During d. frequent stitches through anus. Abo 6.45 p.m. diarrhoea, with some cutting in abdomen and stitches anus. The cutting in bowels and sore feeling deep in abdomen lasc \ h. Ac 7.15, several shoots in second last (healthy) molar tooth on side. 13th. — In m, call to stool without effect, followed by sever*; shoots in rectum. A.m., felt quite well. P.m., frequent shooting i anus and neck of bladder. " These symptoms," says S., "as also th eructations smelling of S. after taking it, recurred more or less ever d., and it was only on one d. — after taking the last dose — that I felt a noon a shoot through the liver (from before backwards), so violent a^ to cause me to start." [Ibid.)

1. Dr. Wachtel made three provings with S.

a. On 19th Nov., 1845, a.m., he took 3 oz. of 12th dil. preparcii with distilled water. P.m., while walking, itching tearing in 1. temporal bone, which came on by fits some 5 or 6 times, and was so violent that it made him stand still j no stool ; nighr's rest disturbed by vivid dreams that remained impressed on his memory. 20th. — No stool ; after dinner jerking tearing in 1. eyeball; at n. vivid dreams. 21st,— A.m., itching and burning in both eyes, folowed by great watering of eyes ; p.m. severe bruised pain in small of back ; stool with burning in rectum. 22nd. — In m. a very firm motion. The bruised pain in small of back became fixed in a small spot, and was aggravated by touch. About noon burning in r. cheek, as if some drops of hot fluid were thrown against it, lasting for 4 or 5 m. j this recurred twice. 23rd. — Pain in back gone ; but instead of it there is a drawing pain in the tubera ischii, in hip-joint, and in upper half of r. thigh-bone, which gradually went off in course of d. 24th. — P.m., itching and burning of skin on I. wrist. In c. there appeared there 7 pimples size of millet seed, surrounded by a red areola, and having a white spot at their apex. 27th, — Quite well.

b. On 24th Jan., 1846, a.m., he took 3 oz. of the 404th dil. pre-

pred with distilled water. In ^ h. flying heat in head ; during dinner drawing and tension in r. thigh, afterwards for instants in I. ; on exfcnding fingers, especially 1. thumb, and in grasping an object, as for "•instance a tumbler, sensation as if tendons were too short, which causes a paralysed sensation. After dinner ineffectual call to stool. * •jn., creeping and burning in skin over zygoma ; frequent micturition ; "fine greatly increased in quantity (about two quarts within 5 h.) ; at "• vivid unconnected dreams. 25th. — No symptoms during d. ; in '• tiresome drawing and tearing (as during first proving) in I. temporal region, 26th. — During whole d, aching in small of the back, Specially severe when making water ; the quantity of water was ^g2n increased to-day. 27th. — A drawing tearing pain came on in r. "PPer arm, which frequently alternated with feeling of paralysis ; W'Orse when at rest, better when moving arm. It lasted with short 'ntervals to 31st,

, ** In March," observes W., " I intended to make my third proving,

"^ X had to defer it in consequence of an irregularity that occurred in

^y abdominal functions, which, as I had never suffered from anything

B^»lar, I am inclined to think was the further effect of the S. Urgent

^T* to stool without result ; tearing and itching in anus, and extrusion

■^aetnorrhoidal tumours; evacuation of fxces of stony hardness; —

J 5^ were the symptoms that frequently affected me at that time. It

, f'^teresting that some affections from which I had suffered when a

L ^*^^ again made their appearance. Thus up to the age of fifteen I

.**4 been troubled with ringworm, for which washings with soap water,

J/Mtictionsof warm oil, and combing off of the scabs had been emploved

*^hout result, until at last I was cured by a homoeopathic remedy,

Y^'^ose name I know not. Moreover, when a child, I had frequently

^cn tormented by the collection of a viscid fluid betwixt my foreskin

^nd glans, which occasioned intolerable itching and burning there;

indeed, the whole urethra was not unfrequently sympathetically affected,

When the passing of water was attended by the most violent pains.

After the second proving of S. my scalp was for a long time thickly

Covered with scabs, and I also observed for several weeks that in spite

of repeated washings every day, a very foetid smegma' was deposited in

considerable quantity on the glans, causing a tiresome burning and

itching. On account of these symptoms I delayed taking more of the

S. till after the lapse of several months."

c. On m. of 17th Oct. he took 3 oz. of 3rd dil. prepared with water. In course of forenoon often eructation of air and more frequent emission of urine. P.m., tearing and aching pain in frontal, which sometimes extended into temporal region, and lasted an h. On taking gentle exercise transient rush of blood to head, with burning and creeping in skin of face ; occasional roaring in ears ; no motion. 18th. — Roaring in ears all d. ; aching pain in small of back ; p.m. burning in eyelids, with flow of tears. 19th. — In m. aching pain in the sacrum, which afterwards extended upwards towards middle of back and betwixt scapulx ; when walking, violent tearing and shooting in r. knee and tibia, then suddenly the pain seemed to jump into 1. and afterwards r. humerus, and so on, changing thus all d. long; after

dinner feeling of prostration in lower extremities. In e. bumi

"^

heat and redness of face, and at same time squeezing feeling 1/ cardiac region. The water passed during n. was cloudy, and of" a penetrating disagreeable odour. 20th. — Ringing in ears and hutning in face recurring several times during d. 21st. — Exhaustion of wboic body; sometimes drawing, sometimes tearing, sometimes dull shooting pains in upper and lower extremities, which leaped from one side to the other. In small of back constant aching pain, which occasioniily went up bacic and extended into chest, with a dull shoot forwards. At noon, while at dinner, sudden recurrence of coryza. 22nd. — P.m., while walking, there occurred sudden pinching pain in r. chest, n»t diminished by standing still, or increased by taking a full brcith » it lasted about ^ h., and went ofi' with a dull shoot towards franC of chest. From 23rd to 27th no new symptoms occurred, but tb^ previous ones occasionally reappeared, especially the ringing in «r»-» the sudden attacks of coryza, the burning and creeping with redness c»^ face, the tearing and drawing pain in almost all parts of body, springinjg from one limb to another, and the itching in anus. 28th. — Perfcd^^ well. 29th. — In e. when walking very tiresome digging and tearing pain in 1. tibia; it only lasted a few seconds, but in course of J h. i« recurred in fits some 12 or 15 times. 30th. — While combing hairi-K^ m. observed a small not red elevation on r. parietal region, sensitive co touch. 31st. — No symptoms. {IHd.)

1. Dr. VVenzl, of Munich, joined our proving Society during hi* stay at Vienna. " When I was scarcely two years old," he says," -» had a severe attack of inflammation of the brain. Six years afterwards I suffered from the same disease, and immediately afterwards 1 v*s aiFected with scrofulous keratitis and iritis, which lasted nine months. Six years ago I suffered from a gastric fever, and three years ago I had another attack of keratitis and iritis that lasted four months. When the ophthalmia was cured I observed a dulness of hearing in the 1. car, in which I had a constant roaring, singing, and knocking, especially on rainy days and after smoking to excess. To this was soon added a peculiar mucous affection, which was particularly increased by the same causes, and which showed itself in an expectoration of mucus in them. The previous year I was seized with a peculiar vertigo and vomiting on walking after dinner ; this vertigo frequently recurred afterwards, but always after dinner, especially when I drank beer during it or coffee after it ; it was combined with a tiresome boring and creeping under the sagittal suture." nth Dec, 1845. — In e. he began a course of experiments with 31st dil., of which he took 1 or 2 dr. every m. and n. at II, up to the 13th Jan. inclusive. 12th. — In m. immediately after taking medicine shooting in tip of tongue, disagreeable taste in mouth. At n. itching on inner surface of fingers of 1. hand and on both wrists, increased by scratching ; disagreeable dreams, with starting. 13th. — In m. feeling of roughness in fauces and uvula; no stool ; itching in hands as yesterday. At n, vivid disturbing dreams ; he awoke &t 3 a.m., and could not fall asleep again. 14th. — During d. same phenomena as yesterday. Waking at 3 a.m. Increased pulsation of aorta from heart to clavicle, combined with a purring noise ; when he lay on

; pulsation was troublesome along the back. Itching on lower

\o(. forearm and on 1. thigh. 15th. — During d. same symptoms

** o;j 13th. N. was more tranquil i sleep better i itching diminished.

'6tii. — The feeling of roughness in fauces worse, especially on swal-

•oiring. The roaring and singing in 1. ear much diminished ; no

Wool,; n. pretty good. 17th. — In m. an evacuation of bowels j no

itchiag. 20th. — At n. many dreams ; he lay 2 h. awake. 23rd. —

Very rough throat. He awoke early in m., and lay awake 2 h. 24th.

— Roughness in throat increased. 27th. — In m. griping in bowels;

feeling of coldness spreading out from lower third of spine over

body and lower extremities ; it was ^ h. before he could get warm in

bed, and all d. long he had rigors in back. Half an h. after taking

medicine he passed a motion at tirst consistent, afterwards liquid ; about

xioon a diarrhoeic evacuation. In e. dislike to usual glass of beer ; very

hoarse voice. 28th. — About 7 a.m. another attack of rigors and

violent griping in bowels; about 7.30 a diarrhoeic stool, and 4 h, aftcr-

wsiids when lying in bed another attack of rigors, which, however,

w^nt ofF after getting up ; very hoarse voice. 29th. — Feeling of

rc^vighness of fauces increased. Erythematous eruption size of shilling

c=»x:b back of 1. hand } no stool. 30th. — Same as yesterday. 31st. —

C>jr«)nvulsive shooting in tip of tongue. Rush of blood to head. Frc-

c^ «-2cnt ineftectual call to stool ; p.m., a very hard evacuation, ist Jan.

In ra. and throughout d. drawing pains in r. gluteal muscles and

«^l~»^osc of upper third of r. thigh when walking, and especially when

■s> «^«oping. 2nd. — Lassitude in all limbs; drawmg pains are stronger ;

^ome cough. 3rd. — Drawing pains extended also into I. thigh, 4th.

-At n. drawing pains in region of 1, eyebrow and aching in I. eyeball,

a* if it swelled out and were pushed forward. The aching in eyeball

only went off the following m. after getting up. 5th. — During d.

frequent tearing in upper and lower limbs and shooting in soles, both

*licn at rest and when moving ; drawing pain in thighs is gone. 6th.

—Tearing pains in limbs not so troublesome ; shooting in soles gone.

7th, — During forenoon aching and drawing pains in occiput. P.m.,

flying shoots in 1. temple and pressure in 1. eyeball. 8th. — In m, after

w^ing fruitless call to stool ; aching in occiput is gone, shooting in

Knple diminished, iith. — At n. restless sleep, frequent waking,

tiresome itching all over body, shooting in tips of ringers. Itchijigstill

Pftjent next m. in a minor degree. 13th. — Frequent shooting in anus.

Night's rest disturbed by lively dreams. Dr. Wenzl w.is prevented

going on with his trials in consequence of his departure from Vienna.

1. Dr. Weinice, 6th Jan., 1846, at 10 a.m. (the h. at which he

took medicine every subsequent d.) took 20 gr. of 3X trit. in half a pint

of water. No effect. 7th, — 90 gr. At noon unusually good appetite.

In c. from 7 to 9 feeling of increased warmth and disagreeable fulness

to whole head. 8th. — 30 gr. of 2x in half a pint of water. At noon

Jost of appetite. During d. frequent hawking up uf blackish gray

masses of mucus, like what happens when one stays long in a room

trberc oil is burned. In e. same feeling of heat and fulness of head as

yesterday, 9th. — 60 gr, in a pint of water. From 5 p.m. onwards

riiAfa

J

frequent dry cough, which does not appear to result from any chi the thermometer has risen lO degrees to-day. From 7 p.m. increased warmth and confusion of head. At n. dreamful sleep with great prostration on awaking. In m, pretty severe cough with some white mucous expectoration. loth. — 20 gr. of i, in a pint of water. At noon good appetite. AJI d. creeping and flying shooting in a wart, its horny surface easily detached, in fact small portions of it fell off spontaneously. P.m., severe cough with little expectoration; on coming into a warm room and on smoking tobacco cough becomes worse; when in open air and on drinking wine in e. it is diminished, indeed it ceases entirely. At n. frequent waking ffom cough, nth. — In m. frequent but looser cough ; expectoration yellowish and globular ; during d. dry cough ; at n. heavy sleep often disturbed by cough. 1 2th. — About 10 a.m. 30 gr. Immediately after taking it, tasteless eructation and very insipid feeling in stomach. P.m., about 4 or 5, when walking in open air, confusion of head, amounting 10 stupefaction, fulness and heat in it ; at same time remarkable unsteadiness of legs and uncertain tread, worse when going upstairs. Great anxiety, which, however, diminishes with above symptoms after drinking a few glasses of cold water. About 6 p.m. dull pressing in 1. chest. At n. restless, dreamful sleep and cough. 13th. — At noon increased appetite. In e., when going to bed, as also in n., on several occasions when he awakes, very violent cough with copious expectoration of mucus. 14th. — Cough loose and rarer. 15th. — Unusually early waking. 16th. — In m. when walking in open air aching shooting pain on whole of r. knee ; when sitting slight numbness and warmth in knee. (This pain was exactly similar to that of a periostitis he had suffered from 3 years before in consequence of a severe fall.) P.m., the pain was scarcely felt when walking. 17th. — In m. after awakmg very violent pains in lower part of knee-joint. When he went out, after taking about 100 steps, he had two cracks in patella and boring pains in it ; he finds it particularly difficult to go upstairs. Bad humour and great disinclination to speak. Cough considerable, accompanied by expectoration. The cough and affection of the joint lasted with slight remissions until 10th Feb. From 18th to 27th Jan. he had severe cramp in calves, which always occurred a.m. when walking and compelled him to stand still, but never lasted long. During whole time of proving he had two to three evacuations daily ; they were loose and smelt stronger than usual. {Ibid.)

1. Weinke now proved the medicine on his two sisters.

a. On 8th Jan., at 9, 10, and 11 a.m., and at 2 and 3 p.m., Mil Helen took 5 dr. of tinct. Immediately after ist dose very severe eructation and inclination to vomit. After second and third doses again eructation but much less severe. After fourth and fifth doses none. At n. good appetite and much thirst. Unusually easy stool. 9th. — At 9, 10, and 1 1 a.m., at 2, 3, 5, and 9^ p.m., 10 dr. Unusually easy stool. At noon great appetite. At 6 p.m. some pimples appeared on arm, which itched very much. Soon after last dose itching on neck, back, and 1. hand. 10th. — At 2, 3, 5, and 9^ p.m. 12 dr. Towards e. shooting in splenic region, which went off after lying

»

if^Xi. nth. — No medicine. P.m., stitches in side of short duration. 12th. — At 9 and lO a.m., and 2 and lo p.m., 20 dr. After the second <lo«e cramp in 1. hand. About lo p.m. stitches in side more severe thin d. before, also felt in n. 13th. — At g a.m. and 3 p.m. 30 dr. After first dose eructation. 14th. — At 9 a.m. and 2J p.m. 40 dr. •^^tches in side still present. Uncommonly easy evacuation. 15th.— ^^ 9 a.m. and 2 and 9 p.m., 40 dr. No effects. i6th. — At 9 a.m. *id 2 and 10 p.m., 45 dr. About 6 p.m. a pimple appeared on nose *nd afterwards several on cheeks, forehead, and chin ; they were red 3iid very painful. 17th. — P.m. ,41 dr. Stitches in side worse. i8th. ~^No medicine. About 7^ a.m. severe aching pain in 1. wrist. Severe *titches in side. Hard evacuation, followed by still more severe ^stitches in region of spleen, igth. — Pain in wrist aiid side continues, Out in slighter degree.

h. 20th. — A.m. 30 gr. of 3x trit. During d. no symptoms. Atn. Cough, sweat, and great weariness of limbs so that she could find no comfortable position in bed. 21st. — Atg a.m. 30 gr. At n. return of dry cough, feeling of great lassitude. 22nd, — At 9 a.m. and 9 p.m. 40 gr. After first dose eructation and inclination to vomit. A large pimple came upon r. checlc. At n. she required to cough frequently, and could not fall asleep again for a long time. 23rd. — At 9 a.m. and 10 p.m. 40 gr. Frequent cough during d. A soft motion. In e. violent shooting in 1. upper lid. Very wearing cough occasionally. 24th. — In m. after getting up great lassitude. A.m., smarting in nose and I. eyelid. In e. vertigo, feeling as if all the blood rushed to head. At 9i p.m. .\o gr. In n. violent griping in bowels which lasted \ h. 25th. — No medicine. Great lassitude in limbs. At 9 a.m. severe vertigo. Many pimples appeared on face. {Ibid.)

1. On 8th Jan., in e.. Miss Theresa took 10 gr. of 3X trit. No effects, gih. — In m. and before going to bed 10 gr. About noon, severe rigor, coryza, aching pain in forehead and occiput especially when stooping. Several pimples on 1. side of neck. In e. shooting in cardiac region, and later tearing in joints of fingers of 1. hand, but only when moving them. Head pained as if raw and would not bear slightest touch. loth. — In m. 10 gr., and at n. before going to bed 20 gr. P.m. a violent cough came on j it instantly went off as soon as she went into open air, but if she returned to warm room it recurred with increased violence. On chin, neck, shoulders, and behind cars, many pimples appeared. On account of the occurrence of the catamenia she left off taking medicine from nth to 14th. On 15th she took at n. before going to bed 30 gr. During this time tearing pain in 1. hand recurred frequently and more violently than before. Fresh pimples appeared on upper lip and nose. Since taking the S. the stools have been quite in good order. She has had daily one, sometimes two, copious evacuations, whereas previously she often had no stool for 3 or 4 d. 1 6th. — In m. 30 gr. P.m. violent tearing pains m I. axilla only whilst she was knitting or sewing ; she had no pain when she laid aside her work. About 5 p.m. sudden tearing in first joint of 1. forefinger and in 1. shoulder. About 10 p.m. shooting pains under r. breast. Heat in head, which long prevented her failing asleep.

I^WI

and heat in the head and tearing

inger-joints of 1. hand and severe

Before going to sleep rigor

17th. — A.m. 40 gr. Several pimples on upper arms and thighs ; gf appetite for dinner. i8th. — No medicine. Very violent shooting^ under I. breast. 19th. — At 8 a.m. such violent pressure on chest that( she could hardly draw her breath ; a fresh pimple on lower lip ; pimples on shoulders and thighs itched intolerably. About 9 a.m. 40 gr. Immediately after taking it rigor lasting J h. About 10 a.m. internal chilliness, shooting in scrobiculus cordis, and several times watery diarrhoea. About noon very great heat, so that cheeks glowed. "I have observed this fever," she writes, " for 2 d. Till 11 a.m, I am always very cold, from 12 to 2 p.m. excessively hot ; from 3 to 4 p.m. again cold ; and before bedtime hot once more." 22nd. — No medicine. At 10 a.m. pressive headache. Appetite uncommonly good, bowels moved easily. 23rd. — No medicine. Oppression of chest from 9 a.m. till 3 p.m. In e. aching pains in 1. frontal region, and shooting in both shoulders. Several fresh pimples on chin. 28th.— At 9 a.m. 40 gr. About noon achinc in 1. knee. 29th. — A.m. tearing in r aching in head. After dinner 40 gr.

tearing in finger-joints. 31st. — Nomedicine. Head heavy and dizzj| bruised pain in anterior surface of thigh ; about 3 p.m. shooting unc heart. The pimples increase greatly, [I6iJ,)

1. Dr. WuRMB proved S. in every form.

a. I took from 23rd to 30th Sept., 1845, at 5 p.m. each d., 20 gr. of the 1st trit. prepared in the proportion of 5 to 95. The only symptom that occurred during the first 4 d. was increase of the urinary secretion, not during d, but in e. and at n. Every n, I had to make water once or twice, and in n. 26th — 27th I passed nearly two quarts. 27th. — In m., immediately after getting up, confusion of head ; after walking, especially after going upstairs, throbbing pains in both temples. The symptoms gradually declined during d., and in e. went ofF entirely. 28th. — Soon after dinner, frequent discharge of flatus, grumbling in bowels, and at 3 p.m. a copious loose stool, although I had had my usual motion in m. The grumbling in bowels did not cease after the afternoon stool (an unusual thing for me), but continued for an h. longer, though less severely. I could not go to sleep before midnight, partly on account of feeling too wide awake, partly owing to a pretty severe itching, which immediately came on in the heat of the bed, appearing now in one place and now in another, and teasing me for an h. I passed water twice during n. 29th. — No stool j feelingof weariness in legs when sitting and standing, not when walking. About 5 p.m. slight confusion of the head for i h. From nth to 20th Oct. I took 20 gr. of the 1^ trit., and on 2 1st and 22nd 50 gr., at 5 p.m. each d. 1 6th. — A.m, an unsatisfactory hard stool ; p.m., soon after taking medicine, dizziness in head. 17th. — No stool ; in m., soon after getting up, dizziness in head, that lasted till 5 p.m. ; on going upstairs aching pains in I. frontal region. i8th, — A.m., an unsatisfactory stool, after a good deal of effort. 19th. — No stool ; great discharge of flatus, distension of abdomen. 20th. — In m., slight compression of head. 2 1st. — In m., immediately after getting up, confusion of head, lasting till noon. P.m., sudden drawing in fingers of r. hand, 1. great

^, and r. tendo Achillis, but especially on internal surface of r. /^^gh. 22nd. — About noon, boring pains in r. inner ankle, which ^*sted nearly ^ h. Not till afternoon, an unsatis&ctory stool, after '^iuch effort. P.m. and e., frequent call to make water (almost hourly), ^which had to be quickly obeyed. At n., in warmth of bed, itching on back and sides of trunk. 23rd. — Oppression of chest, lasting all forenoon. I felt as if my clothes were too tight about my chest and interbred with respiration at the same time. I had often an inclination to breathe deeply. Aching in sternum and obtuse stitches in 1. chest. Anxiety as if some great misfortune were apprehended ; frequent urination ; itching all over body ; at 1. side of upper lip a painful vesicle. 24th. — No stool ; discharge of much flatus j sore pain at raphe of perinaeum ; anxious disposition. 25th. — Great discharge of flatus ; soreness of perinaeum continues. The effects of the S. did not go off till) the end of the month ; they showed themselves in unsatisfactory stools, and sometimes constipation of several days duration.

h. I took a scruple of pure S. at about 5 p.m. every d. from i8th to 30th Nov., and a drachm from 3rd to 14th Dec. i8th to 22nd Nov. — No symptoms. 23rd. — Frequent urination, and generally much at a time. All e. paralytic feeling in both upper arms. 24th. — The paralytic feeling in upper arms came on after getting up in m. and lasted almost an h. At 8 a.m. violent contractive pain in whole r. thigh, which lasted I h., was very much increased by walking, and often compelled me to stand still. In m. scalding on making water ; secretion of urine was very much increased throughout d. No stool. 25th. — P.m., sore pain in both oral commissures ; itching on borders of eyelids. 26th, 27th, 28th. — No symptoms. 29th. — P.m., frequently a raging pain in middle of sternum. In e., drawing on inside of r. thigh } coldness of feet^ which lasted all n. (I awoke several times during the n., owing to vivid dreams, and on each occasion I felt the coldness of the feet), and did not entirely go off till after getting up next m. 30th. — During d., frequent sudden aching in middle of sternum. 1st, 2nd, 3rd Dec. — No symptom. 4th. — About 4 p.m., after a good motion, cutting pains deep in hypogastrium, which lasted a ^ h., and then went off, after the discharge of much flatus. 5th and 6th. — No symptom. 7th. — In m. a loose stool ; whole d. grumbling in bowels } about 5 p.m. another loose motion. 8th. — In m. a loose motion. 9th. —In m. a very liquid evacuation. loth and i ith. — No symptom. 12th. — Frequent urination, sometimes as often as every ^ h., but generally with scanty discharge of urine. About 3 p.m., aching at r. side of region of bladder. In e. drawing backwards in 1. thigh, especially in its middle. 13th. — The drawing pain in 1. thigh recurred in m. immediately after getting up ; it was sometimes very severe when walking, especially on commencing to walk ; on continuing to walk, and also when sitting, it went off entirely, but immediately returned if I only took a few steps. 14th to 21st. — Quite well, so that I thought I had lost my susceptibility for the large doses. I was mistaken, however } for from 22nd I had again a daily recurrence of S. symptoms, such as aching pains in r. side beneath short ribs } irregularity of bowels, — sometimes there was no motion, or they were moved later than usual j VOL. IV. 15

drawing pains in thighs, which did not last long, but often recurrW during d. when walking. This was especially the case on forenoon of 26th, on which d. the drawing pains attained a troublesome degree of intensity, now in r., now in 1. thigh, usually posteriorly. Atsametim^ I had a paralytic pain in upper arms, almost all d. long, and in upp^^ part of trunk feeling as if I had caught cold. 27th. — In 1, forearm, al' d,, violent paralytic pains. It was very sensitive to touch, and my slight exertion, such as the preparation of a medicinal attcnuatior^i caused severe pain in it. In m. itching all over body, especially ibo/C the crista illi. 28th. — No motion. The paralytic pains are present all d., but in much less degree than yesterday. 2gth. — In m. a haro insufficient motion, which on its passage through anus causes burning shooting pains there. In e., when walking, very severe drawing paii** in both thighs. 30th. — In m,, when walking, such violent drawin ^ pains, especially in r. thigh, that I had often to stop, and could notwa!*^ without limping. These pains lasted all the e., even when sitting, an *^ only went off once, for a few moments, to give place to a paralytic pai " in 1. forearm. 31st. — A.m., when walking, aching under 1. short tWs^f" The pain in r. thigh lasted all forenoon j certainly not so severe m^yesterday, but still bad enough to make me limp when commencing c^ walk, when it is always worst. Judging by the feeling this pain *^^ deeply seated in the thigh. P.m. I had no painful sensation, though ' walked a great deal, ist Jan. — No symptom. As no S. symptoim * appeared during the following 9 d. I thought I might begin a net^ series of provings.

e. From luh to 15th Jan. inclusive I took daily at 5 p.m. 5J o» Sooth dil. nth. — Immediately after first dose, confusion of hcaJj which, however, did not last long. About 10 p.m. I went to bed, but could not sleep before midnight. When sleep at length came on, if was disturbed by disagreeable dreams, and only became more tranquil towards m. 12th. — Immediately after taking medicine, confusion of head, which lasted 2 h. About 6, when walking, drawing in muscles of r. calf, which went off immediately on standing still or sitting, but instantly returned on walking. About 8, when sitting, aching under I. short ribs. 13th. — No symptom. 14th. — Commissures of mouth, especially 1., smarted as if raw. When walking several times drawings in 1. thigh. From 10 a.m. to 6 p.m, throbbing pain in 1. temporal region, which was aggravated by walking, and at 6 p.m. suddenly went away. In m. sore feeling in both hypochondria, which are sensitive to touch. 15th. — In m., painful drawing in r. thigh, especially when walking, which alternated with a similar pain in r. heel. In c., frequent urination, almost every i h, I left off taking the medicine ; the drawing pains recurred daily, and only finally disappeared on 24th Jan. Were these symptoms the effects of the high dilution i" Were they not, which is more probable, the after effects of the large doses of S. previously taken ? In order to decide this point, I undertook a new proving with the Sooth in March. I took from the 2nd to the 24th, and from the 26th to the 31st, daily, at 5 p.m., 5J of the dilution. No symptoms occurred ; aiid there was like absence of result from the 400th, 200th, tooth, 50th, 30th, and 2ist,each taken daily for about a

t

""Cci. Now, from July and to 13th, I took 12th dil, in same manner. iiid and 3rd. — No symptoms. 4th. — In m. after getting up drawing in thigh. In course of d. two loose stools. In e. sudden drawing on r. dc of lower jaw ; anxious disposition. I could not free myself from c anticipation of some great misfortune^ though I had no ground for ch fear. 5th. — Two loose stools in course of d. P.m., drawing on side of lower jaw and in 1. thigh. In e. anxious disposition as csterday. 6th. — In m. a loose stool. P.m., sudden drawing in the I. wcr jaw and thigh. 7th. — In m., after waking, taste of blood in mouth i after getting up aching squeezing pain in top of chest, especially r. side, which lasted more than an h. Sudden drawing in third and urth fingers of 1. hand and in I. thigh. About noon, drawing in 1. ide of lower jaw towards its articulation, and for J h. teasing aching in I. ea.r. About 6 p.m., drawing in r. ankle ; burning about lower angle of 1. scapula, lasting \ h. ; sudden aching in hepatic region, and under I. clavicle. 8th. — After dinner, distension of belly ; discharge of much inodorous flatus and a loose stool. About 5 p.m., drawing in I. upper jaw and zygoma ; itching compelling scratching between nngers of 1. band. Night's rest disturbed by many vivid dreams, 9th. — In m,, after getting up, burning in lids, especially of r. eye. About 8 a.m. a Ycry liquid evacuation ; during forenoon, aching in r. eye, and sometimes feeling as if eyeballs were swollen ; drawing in r. molar teeth. After dinner, drawing in r. metacarpal bones (lasting almost all afterown), and in 1. metatarsal bones ; sudden drawing in r. thumb and forefinger, r. forearm, and top of 1. ear towards occiput ; itching compelling scratching on dorsum of 1. hand, and in eyebrows. loth. — In m., after waking, much eye-gum on ciliae ; itching and burning of lids, which are red and swollen. About 8 a.m., drawing in 1. side of jaws, and afterwards in r. thigh and metacarpal bones and fingers of r. hand. These drawing pains lasted about ^ h. About 9 a.m. a loose motion. P.m. felt perfectly well. In e. pain recurred, alternately in r. and I. thighs. I J th.— A.m. not the slightest trace of S. action. Immediately after dinner a loose motion, although I had had a normal stool a.m. P.m. drawing in middle of 1. thigh, afterwards in r. forearm and thumb, then in 1. zygoma towards 1. parietal bone, lastly in r. molar teeth and r. middle finger. Itching, now here, now there, but especially on back of hand and eyebrows. At n. vivid dreams causing me to awake frequently. 1 2th. — In m. I felt in bend of r, elbow a tiresome tension, both in flexing and in extending forearm. During forenoon the drawing pain recurred, first in 1. great toe, then in r. upper molars and metacarpal bone of r. thumb, afterwards in middle of internal aspect of . thigh, and lastly in first joint of r. forefinger. P.m. drawing in 1. hip d I. thigh. In e., itching compelling scratching between fingerotnts. 13th. — The feeling of tension in 1. elbow is present all d., but in much less degree than yesterday ; sometimes drawing in r. thigh. I4ih. — No symptoms. 15th and l6th. — The drawing pains in lower extremities recurred pretty severely. The subsequent days also they returned, but were every d. less severe, until after a week they were

more rrom habit than from necessity ; sometimes, in fact, I had live dislike to ft»d, e$peciall)r at supper, so that I ate nothing. I often much concerned about my sute cf health, and feared lest I might really get ill. At the same time t made the disagreeable discover that mr hair came out much in the m. on combing it. After feelin quite well for a wcck^ viz. from 25th July to ist August, I thei from 2nd to 12th Aug., took every day at 5 p.m. 5] of 3rd dil. Oi 5th there occurred some S symptoms, such as drawing in 1. (hum! and r. upper jaw ; loss of appetite \ two loose stools. Such was t! scanty result of taking S. j for 10 d.

J, Of the pure tinct. I took a drachm-glass full at 5 p.m., from loth to i2ih Oct., from t4th to 20th, on 22nd, 24th, 25tb, 261 2Sth, and 29th, and from ist to loth Nov. It was not till m. of Ocl 13th that S. symptoms appeared, such as drawing in r. upper ar and itching on external aspect of fingers -, these symptoms recurred 01 the following days. A more vigorous action showed itself on the i 7th. Xhe drawing was no longer limited to upper arm, but during forenoon was also present in 1. upper jaw and extremities. It was generally felt first in r. then in I. side, then in r. again, and so on. About 1 1 a.m., aching in region of neck of bladder lasting ^ h. ; afterwards aching in anus. P.m. I was free from all symptoms ; only in e. I was teased with drawing in crowns of teeth. i8th. — Drawing in lira now here, now there, especially in r. wrist. P.m. great distension abdomen with sore pain above 1. os ilii. In e. great lassitude and feeling of weight in legs. 19th. — In m. an insufficient motion folluwei by burning in anus, which teased me almost all d. A.m. drawing teeth which recurred several times, and drawing in limbs } the iattei never lasted long, and always appeared again in another place. Itching compelling scratching, now here, now there. During whole afternoon, head was confused. About 5 p.m., immediately after taking medicine, feeling of dryness followed by scraping in throat ; 5.30, painful shoot along the urethra ; 6, attack of tickling cough, which lasted nearly ^ h. and went off after expectorating a good deal of phlegm. At n., in bed, heaviness of legs. 20th. — In m., in bed, teasing fccBng of weight and weariness in legs. A.m. an unsatisfactory stool ; drawing in teeth, and here and there in limbs, worst in I. calf. About 5 p.m., immediately after taking medicine, dry feeling in throat, and slight confusion of head. 21st, 22nd, and 23rd. — Besides insufficient motions every d., and sometimes a drawing in the r. thigh, no sym ptoms. 24th. — In the m. a scanty evacuation. P.m., immediatcl' after swallowing medicine, confusion of head, lasting about an h. i d feeling and scraping in throat, and occasional cough with expectoration of phlegm. During almost all e., drawing in r. thii>h, especially when sitting, and sudden drawing in fingers of both hands. 25th. — No symptoms. 26th. — In m., occasional drawing in teeth and lim especially r. thigh, 27th. — Nosymptoms. 28th. — P.m., immediate after taking tinct., some painful shoots in urethra, drawing in 1. thig _ dry feeling in throat, and itching on outside of thigh ^ later in e., tickling in urethra. 29th. — Frequent urination, about every h. j a great deal of urine was alwa.s passed at once. 30th and 31st. — Nosymptoms. 1

iras

3N

■m

en

Nov. — Drawing pains in almost every part of body, alternately in one part ind another. It was only in r. wrist and thumb that these drawing pains wete present almost all d. ; they were very troublesome and accompanied by feeling of weakness, so that slight exertion of the r. hand, ^.^. opening adoorand the like, was difficult and increased the pains. Itching on outer surface of thigh, on back of hands, in anus, and particularly in small of hick. About 6 p.m. tickling cough, which lasted about 5 m,, and cosed after expectorating much phlegm, and. — Frequent but never long-continued drawing in the r. shoulder-joint, and continued drawinginr. thumb i itching on outer surface of thighs and on back. 3rd. — Drawing in r. calf, r. thigh, and r. thumb. 4th. — In m., after much cFon, an insufficient lumpy motion, which on its passage through rectum caused a burning pain there. 5th. — P.m. a hard scanty motion, Sudden drawing here and there in limbs. Towards e. I had to make water about every h., and each time passed a great deal. 6th. — In m., iensation as if there was a foreign body in r. eye. 7th. — Feeling of foreign body in eyes, a.m. in r., e, in I. eye ; drawing in fingers of 1. hand and in r. thigh. 8th. — A.m. a lumpy insufficient stool ; drawing in lower incisors, in both thighs, in fingers of), hand, and in back below r. scapula. 9th. — In m., after getting up, drawing in 1. side of lower jaw; p.m. a hard unsatisfactory motion, with burning in rectum. lOth, — In m., tension in r. shoulder-joint, and very painful tearing on imidc of 1. thigh. During d. pretty frequent drawing on inside of 1. thigh and once in r. thumb.

The following days the drawing pains went gradually off and entirely disappeared by the 20th Nov., hence I concluded that I was free from the effects of the S, In this, however, I was mistaken, for hxmorrlioidal complaints now set in, which at first attained a great degree of Kwnty and then gradually subsided ; they lasted fully three weeks. They consisted of the appearance of a large pile, which caused a violent burning pain on walking, on being touched, and especially when u stool; sometimes very painful shoots darted out of it through the inui, and in the first days there was always a little blood passed at •tool, (/hi J.)

1. Professor von Zlatarovich began his proving on 24th Sept., '^45, and finished it on 25th Nov., 1846. It lasted therefore 428 d. During the first 17 d. he took triturations ; afterwards he proved for "7 d. S. in substance, of which he took 5593 gr. During the following 271 d. he used the tinct., of which he took in all 2600 dr. ; ""ring the last days of his proving he took dilutions.

a, From 24th to 30th Sept., and on 4th, 6th, 7th, 9th, and 'Oth Oct., 1845, he took every m., i h. before breakfast, to gr., and 01 12th, 20 gr. of Xi trit. 24th Sept. — In m., i^ h. after dose, shoots *> with fine needles at lower angle of I. scapula, which lasted ^ h., followed by feeling as if upper lip were swelled. 25th, — In m. burning m edges of 1 ids ; upper lid sensitive to touch. In e. sore pain in whole "We, especially in its septum, slightest touch increased the pain. No 't»Ce of catarrh. 26th. — In m. slight burning in septum of nose. About 9.30 a.m. collection of water in mouth, inclination to vomit, snda very copious loose stool, 27th. — In m,, after getting up, several

fits of sneezing, sore feeling in nose, burning in upper lip and edges C J lids. At noon pain in nose was very severe, and an acrid fluid flowe-~^

from r. nostril. 28th. — After dinner, cutting burning pains in bordei '

of eyelids, and especially in external canthi ; a little acrid fluid corner— i from nose. In e,, very tiresome burning in outer canthi, and o^aa shutting eyes sensation as of a foreign body betwixt edges of lid .d towards external commissure; dryness of nose; burning on ouie ^

borders of alx nasi, which are very sensitive to touch. 29th.

After getting up, burning in borders of eyelids. After taking the medicine nausea and inclination to vomit. After breakfast frequent eructation of air ; after dinner itching in anus. 30th. — The nose, especially its 1. outer edge, is very sensitive to touch. In e. cutting pain in nose and discharge of thin fluid from it. ist Oct. — In m. after getting up very tensive sore pain in nose, especially at its point ; feeling as if nose was swollen ; its internal surface is covered with small scabs ; sensitiveness of upper lip to touch ; slight burning of eyes, particularly in outer canthi. About noon increased discharge ' of thin fluid, but no other symptoms of cold. 2nd. — In m. he felt perfectly well; about noon scabs formed on nose, causing tiresome tension at its point. In e. after eating an ice, very disagreeable tas^ and slight nausea. 3rd. — A.m. slight burning and profuse lachryma tion of 1. eye. In e. several violent sneezes in rapid succession. Edges and septum of nose rather sensitive. 4th. — In m. slight adhesion and burning of eyes ; sensitiveness of septum of nose and upper lip. The cutaneous transpiration has an odour of S. 5th. — In e. sudden and very severe itching on r. hand, especially on palmar aspect and betwixt fingers. 6th, — A.m. slight bearing down in anus; transient drawing pain in small of back. At noon burning in eyes; sensitiveness and dryness of nose. P.m. twice sudden tearing in lumbar and sacral vertebrae, and several times very tiresome itching in 1. hand from wrist to little finger. The itching is increased by scratching, which is followed by burning, but nothing is to be seen on the skin. On back near loins, several small pimples which let out a fluid when scratched ; itching on occiput near nape. yth. — In m., on awaking, much phlegm in throat and larynx ; lids slightly adhering ; point of nose covered with small scabs. A.m. dry feeling and troublesome tension in nose; burning of eyes and lids, 8th. — A.m. occasional expectoration of thick phlegm, otherwise nothing worth notice. 9th. — In m, occasional expectoration of phlegm. Sensation of increased heat of face, especially in cheeks and around eyes ; troublesome dryness in nasal cavity. The lips become so dry in speaking that they are quite rough, and cause disagreeable feeling of rubbing ; spasmodic contraction beneath sternum when sitting. In e. discomfort, restlessness, flying drawing in limbs, especially in forearm (judging by the feeling, in the bones). All these symptoms lasted about an h. loth. — Occasional slight burning in eyes; in nose sometimes dry feeling, and sometimes discharge of watery fluid from it. nth. — In m. slight sensitiveness in throat, coughs up occasionally some thick mucus. Towards noon aching in vertex, increased in open air, where it became very teasing ; along with canthi and dry feeling in nose. After dinner

ig

vertex, increased to feeling as if a heavy weight lay on it. This 'in lasted all d. in minor degree, and did not go off till e. In e. otiise discharge of fluid from nose. On r. side of scalp over parietal 'fle a very painful pimple forms. When sitting, burning in anus.

t. On 1 2th he took in m. 5 gr. A.m., when sitting burning d aching in anus^ which lasted an h. ; after dinner flying shoots in Depart. 13th. — 5 gr. He could scarcely wake himself up in m., •ugh he had slept well overnight. After getting up, burning of eyes outer canthi, tenderness of upper lip, and tiresome dry feeling in e. After taking the S. several eructations of gas tasting of it ; ht scraping in throat and irritation to cough ; a hard insufficient :uation followed by burning and sore feeling in anus. At noon t burning in the canthi and dryness in nose ; the upper lip burns as if as raw ; bearing down in anus as if to stool ; very cold hands and 14th. — 8 gr. In m., immediately after getting up, a normal I, followed by straining and discharge of fluid faeces, and raw pain lus. Towards noon, when sitting, frequent straining and aching nus. In e. when sitting, painful shoots in front of urethra, great burning in skin of forehead. At n. violent attack of cough, ■ expectoration of thick phlegm, and feeling of rawness in hea. 15th. — 10 gr. All d. till late in e. burning in skin brehead ; transient sensitiveness of mucous membrane of nose, e. when writing chilly feeling, soon, however, followed by J warmth. The night s rest was disturbed partly by shooting s, of which he was not very distinctly conscious, partly by anxious ms. 1 6th. — 15 gr. In m. expectoration of much thick viscid gm and copious discharge from nose. Soon after taking medicine blesome dryness and sensitiveness of nose. In red part of lower >n 1. side sensation like a chap, though there was none. Towards 1 slight burning of eyes, especially edges of lids ; afterwards, while ig, great bearing down and sore feeling in anus, which became so in an h. that he could scarcely sit, but it went off after dinner. . itching and burning in skin of forehead. 17th. — 20 gr. After ng medicine, a short dry cough as from irritation in trachea, ing d. he felt quite well, but digestion was not quite in order. He with appetite and had no feeling of oppression in stomach ; but ral times after dinner there were eructations of gas, with taste of t had been eaten at dinner. On 1. side of forehead a small in> ed pimple. i8th. — 20 gr. In m. while sitting slight aching in i of back, and some burning in anus. Noisy discharge of much IS. The pimple on forehead is gone. Soon after taking the S., ness all over body and great bearing down in anus. P.m., after :ing a little, a blister on sole of foot ; much thin mucous fluid es out of nose. In e. when sitting, recurrence of bearing down in I. At n. several times hawking up of thick phlegm. 19th. — 25

In m. after a good stool, burning in anus ; discharge of much f flatus. A.m., sudden pressing headache about r. supra-orbital . In e. some pressure on vertex } frequent expectoration of thick gm. 20th. — 25 gr. In m. repeated expectoration of phlegm from nx } slight adhesion of lids. (Some varicose veins which had per-

sisted in r. calf for lO years became visibly less, and a swollen state of whole leg below knee, which had lasted same length of time, is diminished.) 2ist. — 30 gr. In e, some sensitiveness and dryness in nose, and slight burning in both outer canthi. At n. several times expectoration of thick mucus. 22nd. — 30 gr. In m. after waking the nose is dry and tender j slight burning in eyes towards outer canthi ; voice is hoarse i slight irritation in larynx, causing dry cough i upper lip tender. During d. frequent dry tussiculation with only occasionally expectoration of phlegm ; great tension in r. leg, especially in kneejoint. At n. he talks loudly in his sleep. 23rd. — 30 gr. In repeated expectoration of phlegm ; great discharge of flatus ; slight burning in edges of lids. During d. frequent cough. 24th. — 30 gr. In m. discharge of much flatus ; burning of eyes i dryness of nose •, frequent expectoration of phlegm. P.m. and e. frequent dry, short cough. In e. aching and burning in stomach, afth and 26th, — No medicine. 26th. — In c. tiresome dryness in nose ; great increase of wax in ears, especially 1. 27th. — 30 gr. In m. occasional cough with sore pain in chest, and expectoration of thick phlegm ; after a good stool distension of abdomen ; a suppurating pimple on hairy scalp near nape. At noon itching in skin of r. leg. 2Sth. — 40 gr. In m. after waking repeated expectoration (by coughing) of phlegm ; a copiot^^B loose stool followed by some pain in anus j slight burning of edges oPV the lids. After breakfast very disagreeable acrid bitter taste in mouth. A second soft stool (an hour after first) j feeling of sinking in abdomen. About noon, when sitting, pretty severe bearing down and some fine shoots in anus, lasting an h. In e. uncomfortable feeling of general derangement, at same time chilliness and burning in skin above forehead. This burning extends by-and-by over forehead, and there is frequent discharge from nose. 29th. — 40 gr. In m. after waking repeated expectoration of phlegm ; dryness and sensitiveness of nose ; slight burning of edges of lids. About noon, two or three times coliclike pinching followed by discharge of flatus. At noon general discomfort; feeling of illness; confusion of head ^ disagreeable chilliness over back and in limbs. In e. great thirst with desire for beer ; great dryness of nose. 30th. — 40 gr. In m. teasing dryness of nose; expectoration of thick phlegm ; slight burning in borders of lids j after a good stool, aching and forcing down in anus. Soon after taking medicine, rumbling in bowels. At noon increased discharge from I. nostril. P.m. very sensitive to open air ; digestion somewhat deranged. In e. eructation of what had been eaten at noon ; frequent sneezing; itching above 1. eyebrow. Late in e. much fluid comes out of both nostrils. 31st. — 40 gr. In m. after waking much expectoration of phlegm ; rumbling in epigastrium. After getting up burning of eyes; dryness and tenderness in nose. After dinner frequent dry short cough and blowing of nose, in doing which septum burns. Upper lip is very red and sensitive on its inner surface, ist Nov. — No medicine. In m. frequent expectoration of phlegm and blowing of nose ; two loose stools. In e. frequent violent cough, owing to an irritation deep in air-passages. Cough generally dry, only sometimes there is thick mucous expectoration. At n. vivid but unrcmembcred

dreams. 2nd. — 50 gr. In m. after waking repeated expectoration of mucus. After getting up, eyes burn a little ; slight pinching in bowels with discharge of flatus, causing relief. At noon a watery fluid flows several times from nose, causing severe burning at edges of alee nasi. At n. vivid dreams and loud speaking in sleep so as to wake him up. 3rd. — 60 gr. In m, frequent cough, sometimes dry, sometimes with cipectorstion of phlegm ; a copious loose motion. A.m., in the open aifj dryness of the nose, and feeling as if its mucous membrane was iwollen. At noon when sitting, painful forcing down and some acute uitcbes in anus. 4th. — 60 gr. In m. frequent expectoration of mucus; great dryness of nose ; sensitiveness of skin for open air. In e. some transient stitches behind 1. ear ; much itching on whole cuuneous surface, especially r. leg below knee, where some slightly Itddened pimples are visible. 5th. — Same dose, of 60 gr., now continued daily up to I2th. In m. occasional coughing up of phlegm. A.m. great sensitiveness to open air. About noon great hunger ; after taking a couple of soft-boiled eggs, heartburn for i h. In e. frequent ihort dry cough ; great discharge from nose. At n. violent itching on both legs, after scratching a sore feeling remained. 6th. — In m. after waking aching in sacrum ; slight burning in eyes and borders of lids ; Jcveral times severe cough, sometimes with expectoration of thick plliegm. P.m. great sensitiveness to open air. 7th. — In m. after waking cough as on preceding days ; a very painful inflamed pimple on border of 1. buttock in division between buttocks. At noon, when iiting, aching in anus, and feeling as if there was a pile at anus, which however is not the case ; much appetite j frequent dry tussiculation. I la e. great watery discharge from nose, which makes edges of nose I wrc. 8th. — In m. after waking, slight aching in sacrum, and several times coughing up of phlegm. After getting up, he had such a sudden call to stool that he could not get quick enough to the closet, and in consequence some feces escaped prematurely, yet he had no diarrhoea, motion consisting of tough gluey fetid faeces. Two h. later similar stool. P.m. frequent sneezing i some bearing down and '^ying shoots in anus. About i a.m., a very severe headache came on, occupying a portion of vertex about size of palm ; it was superficial and seemed to be seated in brain. The pain was of a drawing burning character, was increased by touch, and lasted an h. 9th. — In m. after waking, transient aching in sacrum ; frequent dry tussiculation ; slight burning in eyes ; dryness of nose. " The effect," says Z., " upon the nasal mucous membrane during the whole of the proving was quite peculiar. At one time an acrid fluid flows from the nose, and again the organ appears to be as dry and stiff as parchment ; the next moment I have to blow out a quantity of thick phlegm, which is ^followed by a return of the dryness." lOth.' — In m. hoarse voice; light burning of the eyes; dryness of nose. At noon great aching id bearing down in anus, lasting an h. In e. when sitting, same Bcling in anus ; it goes off quickly, but after awhile returns ; frequent EvcTc cough. About I a.m., violent cough caused by a constant itation in trachea, and lasting nearly an h. nth. — In m. frequent "coogh, generally dry, and only seldom with expectoration ; a hard

^34

unsatisfactory stool. A.m. frequent blowing from nose of thick mucus. At noon tiresome dryness and stiffness of nose ; forcing down and aching in anus. This feeling in anus went ofF completely when walking p.m., but came back again when sitting in c., but only in fits, for it went off the next instant. In e. much cough, I2th. — In m. slight adhesion of eyelids ; frequent sneezing ; frequent coughing up of phlegm ; hoarse voice ; tickling in larynx and bronchial tubes ; sore feeling in chest ; a copious loose motion. £., when sitting, the aching and bearing down in anus recurs in fits like yesterday. On smoking, mucous membrane of the nose feels sore. 13th. — 70 gr. In m. occasional coughing up of phlegm ; a very solid stool followed by slight burning in the anus. At noon, bearing down in anus. After dinner, great tightness and distension of abdomen. In e. repeated hawking up of thick disgusting mucus, and, when sitting, aching in sacral region, 14th. — 80 gr. In m. occasional expectoration and blowing from nose of thick phlegm. At dinner peculiar feeling in r. nostril ; he felt as if mucous membrane detached itself from bone and rose as a blister, at same time frequent sneezing. These sy ptoms were present almost all p.m. 15th. — 90 gr. In m. loose stool ; occasional cough with expectoration of thick phlegm ; dryness of nose. At noon, pretty severe aching in anus. P.m., sensation in r. eye as if a foreign body were in it, which compels him repeatedly to rub and wipe it. i6th. — Without medicine. In m. copious soft stool, and frequent cough with expectoration of thick phlegm. After breakfast, slight grumbling and pinching in bowels, and in an h. a fluid evacuation followed by sore feeling in anus. An h. later a third similar motion. At noon, when sitting, slight aching in anus, and severe burning and dryness in nose, 17th, — 90 gr. In m. several times cough with expectoration ; at cleft of nates an inflamed pimple, which gave much pain when walking in forenoon. i8th, — qo gr. In m. expectoration of mucus j firm stool. The pimple between nates is still there, but less painful. 19th. — loo gr. In m. severe cough ; a firm solid stool followed in an h. by a looser motion. Skin, especially of hands, smells of S. 20th. — 100 gr. In m. frequent cough with expectoration of thick phlegm; a copious soft stool ; dryness of nose and stiffness of its walls. At noon, burning of eyes, and when sitting aching in anus. 21st. — 100 gr. In m. frequent coughing up of mucus ; a loose motion, followed by aching in anus ; dryness and tension of nose ; tenderness of upper lip. After dinner, coldness and slight pinching in belly ; bearing down in anus. In e., for an h., distension and sinking feeling in abdomen. 22nd. — 100 gr. In m, repeated coughing of phlegm ; a loose stool, followed by burning in anus. An h. afterwards, a second similar stool. After dinner belly somewhat distended. During d. frequent cough, sometimes short and dry, sometimes with copious expectoration. Palms of hands gmdl strongly of S. Towards e. great sleepiness, so that contrary to custom he slept for an h. After waking, aching in anus. 23rd. — iiogr. In m. after waking, great discharge of flatus ; frequent cough, sometimes short and dry, sometimes with expectoration of thick phlegm ; on upper lip a small aphthous erosion ; distension and rumbling in bowels.

'4

In e. some burning in eyes ; dry feeling in nose, although it is actually moist; burning in aphtha on upper lip. 24th. — no gr. In m. coughing of phlegm ; a loose stool ; after breakfast, inclination to go to stool, which however soon went ofF. 25th. — iiogr. In m. immediately after taking medicine, a loose stool ; then for an h. pressure on chest and fulness in stomach. Both symptoms decline on occurrence ^f rumbling in bowels ; frequent cough, sometimes dry, sometimes ^ith expectoration ; eructation of air smelling of S. ; much mucus Comes from nose, and then there is disagreeable dryness of nose ; slight "Urning in upper lip. The aphtha on upper lip is quite dried up. -^fter breakfast, rumbling in bowels ceases, and warm feeling comes in •'onnach ; roughness in oesophagus. P.m. great sleepiness, and after a short refreshing sleep he feels perfectly well, all except dryness of nose. ^^t^h. — no gr. After waking, itching on legs ; several times coughing ^P of mucus ; discharge of flatus, smelling strongly of S. ; a half-fluid, '"^Vtfficient stool. 27th. — 120 gr. In m. frequent coughing up of ^'^'Mcus ; dryness of nose. Although he ate a very good dinner, yet P***., contrary to habit, he became so very hungry, that he had to eat ^l^^in ; nothwitstanding this, he was again ready for supper. In e. ^'yness of nose ; sometimes dry cough ; cheerful disposition. 28th. "^120 gr. In m. cough with expectoration ; feeling of unusual ^ghtness in sacrum ; a curious illusion of the sense of smell, as though **c smelt soapsuds. After dinner, frequent dry short cough. 29th. — ^20 gr. In m. occasional coughing up of phlegm ; discharge of flatus, Smelling of S. An h. after taking the S., a semi-solid insufficient stool; slight constriction of chest. Somewhat later, rumbling and pinching in bowels. About 11 a.m., a second, semi-fluid, insufficient motion ; slight confusion of head. After dinner, great sleepiness } after a short sleep, uneasiness in abdomen ; somewhat later, burning in rectum. In e. frequent short dry tussiculation ; burning dry nose. (The itching in anus, to which he had formerly been subject, went off entirely some time since.) 30th. — 120 gr. After waking, discharge of much flatus, smelling of S. ; a copious loose evacuation. After breakfast, much rumbling in bowels. Towards e. some burning in eyes i very cheerful disposition, ist Dec. — 120 gr. Z. continued to take this dose almost daily up to the 7th, with nothing but the effects already frequently recorded. On m. of 8th skin of whole body smelt strongly of S., in consequence of which he left off the medicine for some d., thinking that it had taken the direction of the cutaneous secretion, and that consequently the symptoms of the other organs had receded. A.m. that d., when sitting, pretty severe bearing down and some fine shoots in anus ; occasional cough. In e. slight tightness of chest, and frequent dry cough. Nose not nearly so dry as on previous days. 9th. — Perfectly well. loth. — In m. occasional cough with expectoration. At noon, when sitting, considerable forcing down in anus, which, as usual, suddenly went ofF, and after a time recurred. P.m., when sitting, pains in tuberosities of ischia, as if weight of body was too great; some itching on external surface of r. leg. nth.— • In m., on waking, headache, having its seat above forehead in hairy scalp, where it occupied a space size of palm ; it was of an aching

prcssivc character, went off when he rose up, but did not go away till far on in forenoon. Skin still smells strongly of S. 12th. — 120 gr. After taking it, some rumbling in epigastrium. In an h., great dry feeling in nose, especially towards point ; an insufficient evacuation. A.m. some burning of eyes. At noon, when sitting, great burning and sore feeling in anus, lasting ^ h. P.m., another insufficient stool. Afterwards, when sitting, forcing and pain in anus occurs in fits, sometimes more, sometimes less severe. Z. continued to take same dose most mornings up to Jan. 19th. [The old symptoms pretty constantly recurred, but we note only those of fresh and peculiar character.] 14th. — Soon after taking medicine, jerking tearing on inside of r. leg ; slight bruised feeling in the thighs; transient tightness of chest. iSth. — He awoke to-day with pains in sacrum, and great itching on r. leg. After getting up the pain in back goes off. 19th.— A.m. sinking feeling in abdomen. In e. uncomfortable feeling in whole body; drawing and bruised pain in lower limbs; oppression and weight in chest. Late in e. a peculiar pain occurred in 1. hand, which began on articular end of ulna, and extended to phalanx of index finger, its seat appears to be in the bone. It is burning, gnawing^ increased by touch, and lasts till he goes to sleep. 20th. — In m. after waking, the pain again came into 1. hand ; it was, however, not so bad as yesterday, but became very severe after dinner, especially when finger was touched, and went off in e. after exercise. Some small vesicles had formed below 1. nostril. 2 1st. — In m, on awaking, transient drawing, gnawing pain about I. anklejoint; pretty severe aching tearing pain in vertex, which went off at noon, but returned very severely p.m. in open air; whole vertex burnt as if raw. In e. flying shoots in 1. tibia (decidedly in bone), which went off in ^ h. 22nd. — Noon, when sitting, peculiar sensation of increased heat in anus, and feeling as if foreign body were there. 25th. — Painful tension in r. thigh down to knee. 27th. — P.m. and e., frequent severe cough ; slight shooting in the urethra. In e. some confusion of head ; cold feet. At n. restless sleep, frequent tossing about and waking, 28th. — In m. general ill feeling ; bruised feeling and drawing in limbs ; aching pain in vertex ; frequent cough, thick mucous expectoration ; slight burning in eyes. P.m. frequent sneezing ; dryness and tickling in nose ; occasional cough ; great sleepiness. Inc. severe catarrhal symptoms ; no appetite for supper. At n. restless sleep, in which he groaned much. 2gth. — In m. the legs were quite wet with perspiration ; severe burning of eyes ; hoarseness ; skin smells strongly of S. In forenoon he was much in open air and felt quite well, but blew much thick mucus from nose. Later, when indoors, nose became quite dry, and its borders stiff. P.m. and e., except a little cough and profuse nasal secretion, quite well. 30th. — Tearing in the right shoulder, which went off in c., leaving a weak paralytic feeling. 31st. — In m. tearing in r, shoulder, which lasts till no<Mi. Jan. 8th. — About 2 a.m. he was wakened by a very violent fit of coughing. This was brought on by irritation in trachea ; it came on in fits, was barking, generally dry, and only sometimes with mucous expectoration. In an h. the cough gradually subsided and he fell asleep

again, but the sleep was restless, disturbed by tossing about, moaning and groaning, breathing occasionally whistling. Much perspiration on r. leg. 9th. — In m. occasionally coughing of phlegm ; feels tired and knocked up ; tension of pectoral muscles on breathing deeply, and contracted feeling in the anterior wall of the chest. P.m. he feels quite well. The urine passed at n. is quite muddy and has a copious sediment. lOth. — In m. after getting up, burning in skin of forehead. At n. some fits of violent spasmodic cough. These fits came on suddenly, were accompanied by a contraction of the air-passages, and went off as suddenly after a few violent coughs. The cough was usually dry, only occasionally there was a serous expectoration. 1 1 th. — In m. he awoke with violent aching-pressive pain on vertex, which occupied a space about size of palm, and only went off some h. after getting up ; at same time general weariness and bruised feeling In all limbs. After getting up sudden pain in the sacrum. At n. severe perspiration on both legs ; profuse secretion of urine of a dark yellow colour. 12th. — In m. occasional violent cough. After dinner frequent short, broken, dry tussiculations. P.m. and e. perfectly well. 1 8th. — On awaking severe burning on vertex, which went on after getting up, and was succeeded by a cool feeling in same place. 19th. — ^Took last dose. In forenoon, while sitting, sudden bearing down in anus ; great sensitiveness to open air. Towards noon, transient aching beneath sternum. In e. hoarse rough voice for some h. 20th. — In m. after waking pain on 1. side of lower jaw and swelling of gum round a tooth, as if a gumboil Were about to come j occasional cough ; some hoarseness ; sensitiveness of eyes ; general lassitude. Not refreshed by his sleep. After dinner great distension of abdomen. 2 1 st. — He was awakened early in m. by a dry, convulsive, violent cough, which lasted an h., and after going off left a soreness of whole chest. Gum on 1. lower jaw is still inflamed. A pustule in r. eyebrow. At noon, some bearing down in anus. In e. gum is very painful ; head confused, its 1. side especially painful ; drawing and tearing in scalp ; 1. submaxillary gland swelled and sensitive to touch. About 2 a.m. he awoke with violent pains in inflamed gum ; they were burning and tearing, and spread all over head ; at same time sensation as if 1. cheek were swollen, wfaich is, however, not the case. After 2 h. he got weary and fell asleep. 22nd. — In m., after waking, feeling of lassitude ; submaxillary

{rland is swollen but not tender ; occasional coughing up of mucus ; a loose stool, followed by aching and burning in anus. 2^rd. — In m. the gum is still rather tender, but swelling is considerably diminished ; the swelling of submaxillary gland too has decreased. A few coughs with expectoration of phlegm. During d. great sensitiveness to open air. 24th. — In m. occasional coughing of mucus ; gum is again more painful than yesterday ; swelling of submaxillary gland is gone. 25th. ■—Swelling of gum gone. In e. occasional tussiculation. 26th. — In m. slight adhesion of lids ; cutaneous transpiration smells strongly of S. At noon great prostration, lassitude, and bruised feeling of limbs. P.m. and e. quite well. At n. much sweat on r. leg ; sharp penetrating tearings on radial side of 1. hand, extending to little finger.

Z. finally took 200 gr. on 29th, but no fresh symptoms occurred,

save that on n. of 5th he had pains along r. tibia, on account of which he could not lie on r. side.

c. Z. now proved the linct. On lith Feb. he took 10 dr. in 1 of water, whereupon violent sneezing almost immediately ensued, 3S.i in course of d. the following symptoms were observed : — A.m., gr sensitiveness to open air ; a painful spot in red part of upper lip. At noon, slight confusion of head. After dinner, aching in vertex and slight drawing in occiput. Although he had had a normal stool in m., yet after dinner a second, of good consistence, occurred — a most unusual thing with him. P.m., temp, about iS'' F., he was wonderfully sensitive to open air, with great chilliness, and frozen feeling, with reddish-brown colour, of hands. The headache went off in open air, but on coming into a room again aching in vertex reappeared, but went off after sitting for a while, when forcing down in anus recurred. 1 2th. — No medicine. On spot where yesterday there was pain on upper lip, there appeared to-day a small pustule ; after this was opened and the matter discharged, it disappeared in a fewh. 13th. — Repeated dose, and so nearly every m, up to Nov. 25th. In m. a copious evacuation ^ several inflamed pimplts in face. About noon some forcing down in anus, which afterwards became very painful when sitting, and was accompanied by single shoots ; it went off on rising up and taking a few turns in room. During d., and several times in c., severe itching on 1. leg. About i a.m. he awoke, and lay awake about an h. On both legs during n. such profuse sweat, that in m. they were still quite wet. 14th. — In m. a copious loose stool. A.m., when sitting, pretty severe bearing down in anus. On upper lip, where was a pustule, there was now a red elevated itching spot. In c. great itching on both legs. 1 5th. — In m. occasional coughing up of mucus ; watery fluid runs out of nose ; several small vesicles appearei^^ on upper lip, which soon dried up ; slight aching pain in a circumi^^ scribed spot beneath chest-walls on r. side, near sternum, — pain is especially observed when breathing deeply and when bending forwards ; a pretty copious loose evacuation, followed by slight burning in anus ; the pain beneath walls of chest disappeared, but recurred about 11 a.m., after burning in anus had subsided. P.m. and e. the pain in chest is only felt when he breathes deeply. At n. a great deal of perspiration obh legs. i6th. — When he breathes deeply aching in chest occurs as ycs^f terday. At noon, on taking a full breath, slight shoots under sternum. 17th. — In m, on awaking, cough several times, with mucous expectoration. The pain under sternum continues in lesser degree ; on leaning forwards the place under sternum pains as if beaten. A.m., some burning on edges of eyelids j frequent sneezing, which increases pain under sternum ; bearing down in anus, especially when sitting. In c. great uneasiness and prostration, so that he has to go earlier than usual to bed. At n. vivid unremembercd dreams ; great flow of urine. 18th. — In m. stool passed in small lumps ; discharge of much flatus ; great itching on r. leg. The pain beneath sternum is felt in m. onU* on breathing deeply ; it increases in the course of forenoon, and goes off'^p.ni^— After breakfast, frequent eructation ; severe bearing down in anus. Al^| noon burning pain in anus, especially troublesome when sitting ^^

**«iall painful pimples here and there on scalp. P.m., dryness of nose.

'9xb.—Dryi

)f

the

iples on scalp gone. 20th. — Nc

^nrss or nose f^ wiptoms. 2ist. — In m., after awaking, pain in 1. forehead, which ited (ill noon. Great itching on both legs, making him scratch, liereupon burning pain remained for some time. 22nd. — No medi- -tic; no symptoms. 23rd. — In m., occasional cough, with expectora- «}n of mucus ; on r. side of forehead an inflamed pimple. After rcakfast, severe burning in anus and rumbling in bowels. 24th. — on&iderab]e mucous discharge from nose, and occasional mucous ex- ^rxctoration ; vertigo lasting some m., followed immediately by slight ^K^ footing in anus. 25th. — In m. pain in r. leg up to hip-joint ; expec- Hbcontion of mucus -, semi-tluid stool. About noon the pain in r. leg, « •^r^pccially in hip-joint, became more violent. Towards c. such violent ■Jtiwing, tension, and bruised feeling on whole anterior surface of r. «.liigh that he could scarcely walk, and then only limping much. The p»in is somewhat increased by pressure. 26th. — In m. expectoration of mucus } pains in the thigh as yesterday. A.m., when walking, these pains go off considerably, but reappear at noon when sitting ; immediately afterwards, cold feeling in both thighs, as if a cold air ^Icw over them. P.m., when sitting, pains in r. thigh were very "iolent; they afterwards diminished when walking, but recurred in e. in a high degree of intensity, and occasionally disturbed his sleep at n, i/th. — In m. burning in skin of the forehead ; occasional coughing of "lucus. A.m., he had to walk much, and when doing so felt almost 10 pain in r. limb. 28th. — Early in m. a very vivid dream, so that he ijJked aloud, and then awoke. After getting up, some constriction of chest ; dryness of nose ; a loose motion, followed by some burning in Mus, At n. sweat on r. foot. 1st March. — No medicine. Beyond ihe usual mucous cough, no symptoms, 2nd. — In m. great drowsiness after a good night's rest ; frequent dry tussiculation i slight tension externally in the chest, at one time below scapula, at another under arms, and at another in back ; fluid frequently flows out of r. nostril. In m. and afternoon a loose evacuation. During d. frequent gnawing aad tearing in bones of r. arm, 3rd. — In m. as drowsy as yesterday ; a few mucous coughs. 4th. — In m. raucous cough ; an inflamed pimple on occiput. At n,, when asleep, frequent groaning ; on account of tensive pain in r. leg he could not lie on r. side. 5th. — In m., after waking, occasional mucous cough ; slight burning of skin of r. leg ; a loose motion ; slight drawing on 1. side of throat to shoulder ; diminution of the falling of hair ; the cutaneous transpiration smells H strongly of S. 6th. — In m. occasional short dry cough. At noon, when V sitting, great bearing down in anus. At n. frequent and copious discharge of urine. 7th. — He awoke in m, with great aching in vertex, which also lasted some time after getting up ; beneath the 1, nostril several imall vesicles ; aching at root of nose. 8th. — Vesicles on upper lip begin to dry up. loth. — P.m. and e. aching pain in r. ear, in external meatus, towards membrana tympani. At n. perspiration in both legs. nth. — Lace in e. aching pain and sore feeling upon and beneath sternum, pain is increased by breathing deeply, by moving body, and by * Prom thi* point we note, as before, only fresh and peculiar symptoms.— Eds.

rough handling ; burning in skin of r. leg. i2th. — In m., on awiking, spot on sternum is still sensitive, but less so than yesterday, 13th.— In m. coughing up of thick mucus ; pain in chest gone. After getting up burning of skin of r. leg and foot. i8th. — After dinner some pain in throat, and contraction of cesophagus. 19th. — Exierniilly, on 1. side of throat behind ear, two painful inflamed pimples, which disappeared following d. 20th. — In c. pretty severe aching pain in vertex. 23rd. — In m., after getting up, slight shooting in I. chest, which recurred by fits several times during d. 29th.— In m., after getting up, aching and heavy feeling in occiput extending into nape ; burning of eyes ; dryness of nose ; coughing of mucus i a semi-fluid evacuation. The headache went off during d. April 6th. — In e., itching on various parts — face, chest, and hands ; after scratching a slight redness appears. 8th, — In m. on waking, headache, chiefly externally, on the vertex, which lasts for some time after getting up. 9th. — In m. a peculiar sensitiveness of wrists and finger-joints, especially on moving them. loth. — In m., sensitiveness and a kind of bruised feeling in carpal joint of r. thumb; occasional short dry cough, immediately after taking medicine, rumbling in bowels ; a soft stool. 1 1 th. — In m., slight sensitiveness and swelling of gums on r. side of lower jaw ; some inflamed pimples at back of scalp. 12. — In m. some burning on r. leg ; swelling of the gums and pimples on scalp have disappeared. During d. two pimples again appeared, one on vertex, the other posteriorly about nape. In e. the eyes burn a little. 15th. — In m., after getting up, severe burning on r. leg; a small inflamed pimple on nape; slight burning in external canthi. 17th. — In m. the canthi slightly adherent; discharge of much flatus. 18th. — In m. slight adhesion of eyelids; some difficulty in making water; occasional coughing of mucus ; an inflamed pimple on back of r. hand ; copious secretion of thick mucus from nose. At noon, great aching and burning pain in vertex; frequent sneezing and dry tussiculation. 29th. — In m., adhesion of eyelids and slight burning of their edges. At nooji, when walking, tensive pain in sole of r. foot; dysuria. (For several d. it had required an effort to empty the bladder.) 30th. — After dinner, when standing, great tension and weight in the right leg ; on occiput two painful pimples, and a similar inflamed pimple on middle of vertex. May 2nd. — After dinner tensive pain in r. foot. 7th. — in e. frequently recurring tiresome burning in 1. eye, followed by lachrymation ; itching in occiput, making him scratch, 9th. — The urine passed in m. did not flow in a full stream, but by jerks; some bruised feeling in the muscles of the spine, nth, — At noon, for i h. great itching of 1, eye, with lachrymation. At n. profuse perspiration on r. leg. i+lh. — In m., after waking, transient but pretty severe pain in sacrum ; urine is passed in a slow interrupted stream. In e. he observed on dorsum of both hands beneath skin, when this was tightened by flexing the joints, small pimples in considerable numbers, which, however, neither itched nor displayed any difference of colour from rest of skin ; hands smelt strongly of S. 1 6th. — In m., after getting up, pain in ribs, vertebrae, and muscles, so that he could scarcely bend forward. The pam was diminished by

2+1

hwldiog himself uprij^ht, and was quite gone in an h. After dinner,

iching in both temples; a painful pimple on vertex. 19th. — In m.,

on iwaking, great aching in vertex, which continues for some time

»flcr getting up; eyelids somewhat adherent ; blowing of thick mucus

from nose, and coughing of mucus. A.m., frequent tearing in r.

wrist In m. on awaking, and after dinner, aching and sore pain in

gums of lower jaw on r. side. At n., perspiration on r. leg. 20th. —

Sertnl painful pimples on occiput. *' I must," says Z., " repeat the

rtiMfk, that the large quantity of scales I used to have on my head for

tome rime back have quite disappeared, and that I cannot now bring

iWij anything of the sort by strong combing and brushing ; but the

hair on the vertex is falling off considerably, so that a bald place is

beginning to appear." In e. the gum around the stump of a tooth in

r. lower jaw is painful as ifaparulis were about to form; the eyes

burn a little ; and the hands also are tender — just the sort of feeling

one has on entering a warm room after the hands have been much chilled

in winter. These sensations went off before bedtime, 22nd. —

After getting up, burning in r. leg, and at n. much sweat there — a

»Tmptom which recurred almost every n. about this time. 2gth. —

uic. small boil on back, which is not painful, but when squeezed dis-

chugci a considerable quantity of blood and pus. On r. side of hairy

wlp a small painful pimple. 30th. — On I. side of forehead a small

infijmcd boil, ist June. — An insufficient, difficult stool, with feeling

of distension in the abdomen ; slight drawing in the occiput and nape;

two pustules on forehead. A kind of creeping feeling occasionally in

beatl, especially on parietal and occipital regions. On dorsum of nose

» red inflamed spot, like a commencing boil. Atn. moderate sweat on

the whole body. 2nd. — In m., after waking, great pain in gastric

region ; when he turned pain went from one side to the other, and

went off when he got up. At noon very troublesome aching pain in

the nasal bones ; two inflamed pimples above 1. eyebrow. At n. profuse

L^ iirnt. 3rd. — Towards m. burning pain in stomach. During d. severe

^■aciiing in nasal bones. 4th. — At noon very severe aching in nasal

^■boncs and creeping in both temples. At n. perspiration all over body,

^Btipectally r, leg. 6th. — After getting up severe aching in stomach and

"slight burning of eyes, especially their external canthi. On every

movement of body, as also in drawing a deep breath, dull aching pain

and shooting in bend of last 1. false rib ; pain was limited to a

small spot, and went off after washing with cold water. 7th. — During

d. very frequently a disagreeable feeling of aching and fulness in nose,

as if nasal bones were thickened and swollen. No change in nasal

secretion. In e., after a short drive, such a severe aching in sacrum that

■M^ give him great pain to sit down and to get up again. 8th. — In m.

^Bevcre aching in nasal bones and dry feeling in the nose. The aching

in nasal bones went off a.m., but recurred at noon in great intensity,

and went away again in an h. 9th, — In m., on awakini;, I. auricle is

painful as if sore, on a limited spot. At noon severe aching pain in

nasal bones and dry feeling in nose, though a drop or two of fluid

occasionally escapes unobserved from the nostrils. loth, — After break-

faat great flickering and luminous appearance before the eye — chruptia.

roL. tv. 16

Everything appeared to be in a quivering movement. This symptom lasted an h. 13th. — On vertex several small painful pimples. P.m. there appeared on dorsum of r. hand, at joint of middle finger, a group of pimples size of poppy seeds, which seem to be under the skin, are not red, do not itch, and which go oiF after 3 d. 17th. — Towards e., in open air, severe dull, hot, tensive shoots through r. external meatus. 20th. — On r. index, where he had had a humid eruption many year* ago, there appeared some hard points, so that skin has a rough appearance. A pimple on the forehead, which had appeared on 17th, swelled up during the past n., and is filled with pus. 23rd. — On vertex a small painful pimple ; the pimples on r. hand arc to-day reddened and itch a little ; occasional aching in the nasal bones ; the lunula, which used to be present on both thumb-nails, is almost gone. P.m. the pimples extended all over back of r. hand. 24th. — A painful pimple on middle of vertex. In e. painful pimples here and there over hairy scalp; violent tearing scraping pains in middle of r. tibia, and also, but not so severe, on vertex and in bones of r. forearm. 25th. — Pimples on back of hand are going gradually ofF; those on index continue; an inflamed pimple on chest and several on hairy scalp ; a small pimple on r. cheek ; occasionally tiresome aching in nose. 26th. — For some d. past very urgent sexual desire. 29th. — At noon sore feeling on spot size of a crown in middle uf r. tibia ; this pain lasted some h. in afternoon, and went off towards e. to give place to aching pain in sacrum, which was especially felt when walking and standing, less when sitting. 3rd July. — Penetrating shooting and drawing in 1. zygoma. 8th. — On index of both hands, on 1. thumb, and here and thereon hands, aie small vesicles, singly or in groups. They are filled with a fluid, but do not itch. nth. — Several new vesicles appear on the hands. I3ih. — Eruption on hands itches a little. 14th. — The vesicles on the hands begin to dry up. 16th. — Frequent drawing in tibiie ; on hairy scaJp several small spots covered with thin scabs. i8th. — Scabs on scalp are loosening. From 20th to 25th some diarrhoea, at first with much griping. 3rd Aug. — A painful inflamed spot in red of upper lip. 4th. — The spot on upper lip is swollen and burns extremely. 5th. — The inflamed spot has turned into an aphtha. The eruption on hands is still present. 6ih. — The aphtha begins to dry up. 14th. — Some backache, with tension and weight in sacrum ; sensitiveness of eyes. 15th. — In m.,on awaking, severe drawing and bruised pain in r. thigh ; some backache, especially when stooping. The vesicular eruption on hands is nearly gone, skin onaflcctcd parts is still rough. 22nd. — At n. and in m. acute stitches through last joint of 1. little finger. 24th. — On lower lip several painful humid vesicles ; on forehead an inflamed pimple. 25th. — The vesicles on under lip begin to dry up; the pimple on forehead is full of pus ; a great eruption of vesicles near I. commissure of mouth. 28th, — The vesicles near the mouth are dried up, but fresh ones have appeared on r. side of upper lip ; on forehead an inflamed pimple. 4th Sept. — A.m., profuse perspiration. At noon peculiar uneasiness and excitation of nervous system. 5th. — All d. great perspiration on slightest movement. At noon tiresome aching pain in bones of nose. 6th. — In m. occasional expectoration of mucus. In forenoon profuse

perspiration. The toe-nails, especially of middle toes, have become ^^^ck, horny, and misshapen. 7th — nth. — Much perspiration, espefiaJly a.m. » the perspiration occurred at every movement, and was r^c/ierally greatest on occiput. 17th. — At noon very violent sneezing, ^n successive times, followed by frequent dry tussiculation. After ■lirncr, tension in pectoral muscles. At n. slight febrile excitement; fx-«quent coughing and blowing of nose ; slight burning of eyes ; oppresi^ion of head and aching in vertex. 18th. — P.m., great oppression of l^d ; aching in vertex ; tickling in larynx ; frequent hawking. At n. 'ioknt pains in r, leg, which did not allow him to lie on that side, ^th. — The catarrhal symptoms somewhat less to-day ; tension between Kzapulae, lasting \ h. After dinner pretty severe pain in r. leg. :2.Cth. — In m. r. leg is very painful ; r. shoulder and upper arm are also x^ci free from pam ; frequent cough, sometimes dry, sometimes with mucous expectoration ; afterwards severe tearing in r. shoulder. Oct. y th, — A.m., acute tearing in r. ring and little fingers ; after cessation of t fie tearing there remains for a considerable time a creeping sensation in ^oth fingers j 1. wrist has for some d. been sensitive to touch externally on its ulnar side. 8th. — In e. much cough-, hoarse voice. <) ih.— Towards m. frequent dry cough. A.m., roughness of voice j • peilcing requires a certain effort. P.m., frequent coughing up of n:<ucu$. In n. awakened by a rather severe but transient pain in 1. fxwital region, loth. — Tenderness on wrists has gone oft", i ith. — In e. fuugh voice. i2th. — Roughness of voice, lasting all d. 15th. — In m. coughing of mucus ; a suppurating boil on r. whisker ; skin of back is covered with elevations ; a constrictive pain in cardiac region that had Iwii there for some d. is particularly troublesome to-day. After iiniwr rather severe itching of edges of lids, especially of r. eye. i8th. —The horny thickening of the toe-nails has considerably diminished ; the nils of fourth toe of both feet arc still thicker than usual, but much Ittisothan during summer. 20th. — Towards noon, anxious, aching, contractive pain in cardiac region. 22nd. — In e.j after reading for >ODictin)e, severe aching in both temples. At n. great flow of urine, ynl. — Keeling over body as if ants were running about. 25th. — During ""thijfof n. much groaning and tossing about in sleep. 26th. — He okcin m. with violent pains in 1. frontal region, which lasted till he P' up J afterwards there occurred severe mucous cough and great dis- "Wfge of flatus. In forenoon very severe aching pain in nose about its '", with dryness of Schneiderian membrane ; frequent shurt dry 'u«iculation. P.m., when sitting, severe burning and tension in r. leg. "ov. 6th. — He awoke in m. with violent achmg throbbing pains in ""wn ; pains went off gradually after getting up. 7th. — P.m. the '^farihal symptoms recurred very severely, to wit, cough, hoarseness, ^fjna&ind aching in nose, with confusion of head. At n. rattling in ditst; violent cough with much expectoration, nth. — ^In m., on **»king, violent aching pain in vertex ; pain was relieved by getting ''ftl>ut not quite removed; at the same time great itching on the ^fiput, compelling him to scratch ; frequent cough, sometimes dry, •oinetimes with mucous expectoration; severe burning on r. leg; ■'•ch mucus blown from nose. At noon tearing in r. leg towards

ankle i on r. temple a small painful spot covered with papula:. I2th. — In m. much cough, generally fatiguing, short and dry, with some feeling of pain in chest. Discharge of much flatus ; burning on r. leg. After breakfast aching and sore feeling in chest ; blowing from nose of thick mucus. 13th. — In m. coughing up oj mucus ; discharge of mu^ " flatus; in forenoon occasional violent cough } lachrymationwhen walki in open air ; sudden aching pain in sacrum ; tension in whole r. I especially thigh and knee. P.m. and e., rough hoarse voice and mu dry cough. 14th. — In m., on awaking, violent pains in r. foot ; they ai of an aching and drawing character, and are only a little relieved aft getting up; a loose stool followed in a (ew m. by burning in anus, lasting 4 h. ; frequent stool; dry cough. After midnight excessively violent pains in 1. lower jaw ; the pains were drawing, pressing, proceeding from a healthy tooth, spreading over whole lower jaw, extending to temple and ear, and lasting till he got up the following m. 15th. — In m. discharge of much flatus ; great aching in a spot on the sacral region the size of a crown ; he looks ill ; has double rings round the eyes ; perspiring uncommonly in axillae ; a loose stool, followed by burning in anus. At n. two his of coughing, one of which lasted at least i h. ; the other was shorter, but much more fatiguing. 16th, — In m. profuse perspiration on both legs j slight burning of tarsal edges ; occasional violent sneezing ; some tenderness of 1. lower jaw ; discharge of much flatus. At noon rough voice ; frequent short dry cough ; the cough also occurred several times p.m. and e. In e, occasional pain in 1. lower jaw. 17th. — In m. a few coughs with mucous expectoration ; great discharge of flatus ; an inflamed pimple on nape. Towards m. some pain had occurred in 1. lower jaw, sometimes with drawing into I. ear. In forenoon in the open air the pain increased ; it was a very painful drawing, which extended not only over jaw but over the whole of 1. side of face. One spot on lower border of jaw was especially painful, also when touched ; in e., in open air, the pain extended in an aggravated degree all over lower jaw, l8th. — In m. drawing in the lower jaw ; discharge of much flatus. All d., with exception of a few coughs, quite well. igth. — Towards m. the pain in 1. lower jaw, especially about a loose tooth, was extremely violent, loth. — In m. frequent cough, generally with mucous expectoration ; pain in lower jaw ; great itching in r, leg. During d. occasional sharp tearing in 1. lower jaw. 2ist. — No medicine. In m. occasional coughing up of mucus ; I. jaw but slightly painful ; great discharge of flatus. After dinner dry tussiculation ; severe coughing, and sensitiveness of the fauces. 22nd, 23rd, and 24th. — No medicine. No symptoms, except the usual coughing up of mucus in m.

d, 25th. — Z. began a fourth proving in m. with 10 dr. of tst dilution of tinct., and the same d. he observed the following symptoms : — A.m., while walking, a sharp cutting in r. shoulder, which was often repeated. P.m., some tearing in lower part of 1. leg. During d. frequent rather violent cough. 26th. — 10 dr. In m. very painful tension from r. shoulder towards back, whereby movements of arm were somewhat impeded. 27th. — 10 dr. In m. occasional cough. In forenoon, when walking, severe bearing down and cutting in anus ; when sittin

g

«45

rfioe symptoms went ofF. After dinner, all afternoon and e., disagreeable horripilation over whole body ; no appetite for supper. 28th. — No medicine was taken from this d. onwards. In m., after a good stool, burning in anus; languor and prostration; little appetite for bmkfisi. At noon a second copious quite thin stool ; looks ill ; tendc/nen of the head at crown ; horripilation and chilliness over whole body; hands and feet especially are cold ; he loathed his dinner. P.m., two liquid stools; constant chilliness; weariness. About 6 p.m. he went to bed ; for long he could not get warm ; hands and feet were especially cold. At n. much perspiration all over body. 29th. — In tn. slight uneasiness ; a liquid stool ; pressure on eyelids ; rumbling and gurgling in bowels ; occasional aching in root of the nose, betwixt the shoulders, and all over back. 30th. — In m. severe burning in stomach ; occasional cough ; great discharge of flatus. Towards noon some aching m nasal bones. At noon more appetite than on previous days. Alter dinner recurrence of aching in nasal bones ; a tender spot in 1, Batril; frequent sneezing; looks ill; emaciation, ist Dec. — In m. OCosional coughing of mucus. P.m., slight heartburn. 2nd. — -In m, itching of scalp ; small pimples in nape and behind ears ; sudden burning pain in anus. After dinner some heartburn, jrd. — In m. severe cough ; a painful pimple on r. eyebrow. 4th. — In m. severe itching in occiput ; discharge of much flatus. 5th. — In m. severe tension in '■leg; aching in nasal bones. The Sulphur symptoms diminished griduallvr, and disappeared entirely towards the end of December. (Hid.) '

1. Taken in doses of 6 — 8 grm. <or an adult, 2 — 4 grm. for a child, S. acts as a laxative, without giving rise to much colic. But when it is given in fractional doses, so that 4 — 8 grm. per diem are consumed, a general excitement is seen to supervene, characterised by increase in frequency of pulse and heat of skin. At the same time the ^^in exhales an unmistakable odour of S. ; the stools and flatus become ixni; and any silver carried on the person becomes darkened by the •«lphuretted hydrogen which escapes from it. (Trousseau at Pidoux,

II. Pejsontngs. — i. A child, act. 2, seemingly vigorous, had been

pven a small dose of S. with molasses, twice a d., for some supposed

impurity ot blood. One e. she took by mistake a whole teacupful of

the mixture, containing more than a tablcspoonful of S. Early next m.

slie woke fretful and restless^ and complained of being chilly. Head

won became hot, and extremities cold. Slight twitchings of muscles of

and cxtremitities were noticed, which soon developed into a

encral convulsion. This subsided in a few m., consciousness returning

lowly. In a few h. there came on a severe chill, followed by heat

and perspiration, which lasted 8 — 10 h. The chill then came on more

severely than before ; and as soon as reaction was established the spasm

returned, this time in the tonic form, affecting first the r. side, then the

front of the body, afterwards the back, and finally the jaws. The

ter were so firmly set that nothing could be administered by the

The whole abdomen had now become enormously distended

Cfmpanitic, and the pulse feeble and intermitting. Simultaneously

1*6

with the spasms, copious discharges from the bowels took place, of the oooststeoce of chin mush, of dark grey^ colour, and very foetid. These were soon ftiUowed by subsidence of the spasms ; the muscles immediatdr rebzed, and the child died instantly. No autopsy was made. (Stebbixs, N. f. State Htm, S»c. Tram., vii, 732.}

1. J. K — , art. 32, smoked three pipefuls of S. one e. in rapid MKceflMMi «s a cure for toothache. He then went to bed and fell asleep, bat awoke in an h. in great fright and distress ; his sympcoms wete— dyspnoea to a sense of suffocation, severe constriction of chest, extreme faintness, vehement palpitation of heart, and horror of instant death. There was general tremor ; his head seemed to him distended, with loud noises in the ears ; he distinguished especially a boring pain over I. eye. His bowels were obstinately obstructed for 4. d., no action being produced by the various aperients he took. The d. after smoking the S. he had intolerable itching over whole body ; this was followed, in a d. or two, by the appearance of reddish blotches over trunk and extremities. He had severe pain across loins. When seen his face was pale and collapsed, with an expression of great anxiety ; there was still v-ehemeut palpitation, pulse feeble and very irregular ; considerable dyspncea with sense of constriction ; intense headache, with sensation as if head and ears were stuffed ; loud noises in ears ^ tremor of limbs, with considerable itching of arms and legs, though no eruption was to be seen ; he complained of pains throughout body. Pulsatilla, and a few doses of Aconite, were given ; and after 9 d. there were no symptoms remaining, save very slight uneasiness on taking a deep breath. {Brit, 'J awn. of Ham,, iv, 92.)

2. a. I have personally experienced considerable inconvenience from inhaling S. fumes when superintending their employment. In addition to their inducing hemorrhoids, I have, on several occasions, been threatened with asthmatic attacks, to which I have no natural tendency.

h. A lady, who inhaled sulphurous acid for bronchitic asthma, derived some slight benefit, but a genuine hysteric paroxysm occurred and lasted several h. The same thing happened again and again, a species of choreic Jerking accompanying the paroxysms ; so that at length it was left off. (Similar effects followed even its external application for pediculi.) The experiment was now tried of burning a few gr. of S. n. and m. At first the patient liked it, and found it relieve her chest \ but in a few d. I was hastily summoned, and found my patient labouring under the depressing effects of hysteria. (Morrisson, M. H. R.y xiii, 159.)

1. We take as a type of sulphurous mineral waters those of the Eaux Bonnes in the Pyrenees. The elective action of these waters on the respiratory apparatus is incontestable. It it rare that after three or four weeks of their use patients fail to experience a sensation of acrid burning m larynx and isthmus faucium, a dry, choking, peculiar cough, with constrictive irritation at the entrance to the airpassages, a little dyspncea mingled with feeling of weight and contraction of thorax, wandering paius in the walls of the chest, especially under the clavicles, and so forth. Catarrhs are frequently set up, and

slight and transient hxmoptyses are not uncommon. (Trousseau et PiDOojc, op. cit.)

S- a. Towards the middle or end of the treatment of phthisis ^^bythe Eaux Bonnes the patient complains of more frequent, drier, ^■idii rr&ore painful cough, with feeling of heat and burning in the throat, ^^nd at the same time of pain in the body and drowsiness. Sometimes r the humid rales are superseded by dry sooffles, as if the secretions of the small caverns were arrested. At the same time respiration in the unimpaired portions of the lung assumes greater energy, and denotes this by a vesicular murmur, which is stronger, more strident, and much lilce puerile respiration. One would say that the contractile element 0^ the bronchi is increased, that their tonicity is enhanced, and that there exists, as it were, a spasm of the last bronchial ramifications and Pwinonary alveoli. The Eaux Bonnes may go so far as to create a«iftcial asthma.

^. There is no doubt that the Eaux Bonnes may bring on spitting "' t»lood in phthisical subjects, since they are capable of producing the settle result in individuals whose air-passages are quite unimpaired. 'L-Eudet, Practitioner, xi, 1 1 1 — 1 13.)

1. The following pathogenetic effects of the Harrogate sulphurous

^J^tcrs were collected from self-provings ; from information given me

y persons of both sexes who had drunk the waters and bathed in

•^^m, experiencing certain of their effects ; and, lastly, from others

^ho were under treatment for various ailments, which were more or

'ess aggravated by their abuse.

a. Nervous system. — Temporary loss of sensation of one or more of the extremities — semi-lateral in some persons ; temporary loss of motion of one or both legs in others^-of one arm in a little girl, from bathing twice during the d,, i h. at a time ; irritability of temper ; low spirits ; discontent ; aversion to society, dissipated by motion in open air.

l>. Cephalic region. — Pressive semi-lateral pain ; heaviness of whole head ; vertigo on motion ; giddiness with nausea. Inflammation and agglutination of lids in m., with heat in eyes, which water when open, and prick, conjunctiva reddened. (Being myself subject to a chronic relapsing ophthalmia, contracted in Africa five years previously, from which I was apparently free, it made its appearance on the 8th d. of a course of 6 oz. of the water taken twice daily. It was relieved by using same water, much diluted, externally. It also reproduced deafness in two persons who had suffered from this affection temporarily, with buzzing in ears and itching in meatus — relieved in open air.) Erysipelatous inflammation of nose, presenting a superficial shining, similar to that of drunkards, which disappears out of doors ; eruption of red spots like measles on face, aggravated by sun and wind. Bleeding from mouth in plethoric persons ; dryness or clamminess of mouth and throat; thirst; dry tongue; roughness of palate; metallic or sweet taste ; thick saliva.

f. Throat and chest. — Roughness of larynx and bronchi; hoarseness; difficult expectoration; greyish bloody sputum in persons of sanguine temp. ; cough in a warm room, with dyspnoea. Decreased

24^

secretion of milk in nursing women. Red spots on chest ; stitching pain in r. chest, increased by respiration ; anxiety and asthmatic feeling after a substantial meal, and on running upstairs or other bodily exertion ; oppression of chest after mental labour. All these symptoms aggravated indoors, and relieved by standing or walking opposite the wind.

</. Abdominal region. — Slow and weak digestion ; fulness of stomach ; want of appetite ; putrid taste in m. ; nausea; shooting pains in liver ; relaxed bowels with watery stools when water is taken warm, tenesmus and costiveness if it is drunk cold; colicky pams ; tightne^ across abdomen ; feeling of distension after a meal, however frugal ; diarrhoea, — bilious, with pain in stomach, in pregnant women, flocculent in old people, frothy in nursing children whose mothers take the waters ; itching of anus, with enlargement of veins.

e. Genito-urinary organs. — Pain in glans ; itching in urethra ; painful urination, with flocculent sediment ; excessive sexual desire ; involuntary emissions ; enlargement of testes j swelling of labia in^ clitoris ; menstruation late, scanty, of short duration, painful, the flo^^ pale, watery, or viscid.

jf. Circulatory system. — Accelerated heart ; pulse irregular ar*** wiry after a meal, and after active exercise ; cerebral congestion ; apc^" plexy. (Dr. Kennion states that this last is no uncommon efFea unmeasured drinking of the waters.)

g. Skin. — Red spots all over body, resembling flea-bites ; cruptioii of little pustules on head and arms, with violent itching ; pointed" vesicles on fingers ; patches on chest and abdomen, some on face, son^ on nose, very red — all aggravated by heat and in close apartments, relieved in open air,

h. Muscles, &c. — Shooting pains in different regions of body, \with rigidity of affected part, dispelled by friction and slow motion ; wandering pains in extremities, lasting but a short time ; erratic numbness in 1. thigh ; torpor in arms with stupefaction of sensorium, aggravated by high winds and change of temperature, by ram particularly and thundery weather ; pressive pains in sciatic nerve, from hip downwards > rigidity of r. thigh j contraction of r. knee and foot for short time; gastralgia ; violent pain, of short duration, in nerves of face, at zygomatic process principally ; contraction and drawing at nucha. 1. Lymphatic and glandular system. — Enlargement and induration of thyroid gland, with burning sensation, which disappeared from friction. Induration of breasts in a nursing woman ; painful sensation in glands of neck, which are swollen and knotty ; shooting pains in liver.

/'. Fever. — Real fever was not observed in any of the provers. Some had erratic chills, following a sensation of heat in the evening, which passed off by keeping indoors and drinking something warm; whilst others had creeping shuddering without chill, no thirst, no sweat. A woman who had bathed in one of the cold water sprmgs for several d. had a very mild quotidian fever ; she got well in a d. under Cedron 3. (Casanova, Brit. Journ. of Horn,, xxi, 354.)

1. Some dark coloration and much irritation of the skin may occur

(torn the internal use of S. I have seen a red papular eruption from it, uid also occasionally boils and carbuncles. The waters of Harrogate, Birega, Aix-la-Chapcllc, &c,, have been known to produce such effects. (Phillips, op. cit.)

1. After using warm S. baths for several d. there is produced an eruption of small, red, acuminated, pruriginous elevations, and of red jpots, which appear first upon the limbs, but soon spread to nearly the whole surface of the body ; a febrile movement, with thirst and loss of i{ipetitc, IS developed ; sleep is restless, urine cloudy and muddy. In 1—2 weeks these symptoms disappear in the order of their coming, the epidermis separates in branny scales, but the skin continues to itch for wnetime longer. (Rayer, in Stille, op. cit.)

2. A Bjr means of the jotb dil. of S., given in doses of i globules every in. for a "«k, Ihaie developed the most intense stomatitis.

i. A voung man, who had never experienced any chest syinptomB, took m. and ». »dr. 0/ the joth as an antidote of mere. corr. On the 4th n. he was seized with a ittuk of convulsive dyspnoea, exactly Mmilar to angina pectoris. This attack "» repmdiiced on 3 successive n.

r. A violent sore.throat, with swelling and redness of tonsils, pain in throat and ■Inp^igia, and bronchitis, witli frequent coughing and dyspncea, agitation and slceplewttn, occurred in a young man to whom I had given the tinct. during seventi WBWuiive d. (Andrieu, M. H. R., i, 300.)

18, A woman, art. 36, of nervous temp., took Sulphur 30 for neuralgic pains, Slifreponed that she had received much relief from the medicine, but that it had Wnl umcwhat too powerfully upon her, having brought on violent purging and 'oictnui a few h. after she had taken the third tcaspoonful, which continued tkmiighout the greater part of the following d. On two subsequent occasions a "■"lila result followed the medicine, (hough blank powders interspersed were without ''^ci. (LAVtLit, Brir. Journ. oj Hom.,ii{, 9Z. "I have repeatedly obser'ed the i^r effeci*,*' adds Dr. L., " in extremely susceptible patients after the administra- '«i>ofS, at various potencies.")

m. Experiments on animals, — i. Benk found that in dogs S. occasioned anorexia, thirst, and diarrhoea. Temp, at first was raised, Imt ifterwards it fell below natural standard; at first, too, pulse was "•ore frequent, but subsequently became slower than usual ; there was "also embarrassed breathing, slight general trembling, convulsions, and »u<iden death. The effects of S. upon cats were nearly the same, but with the addition of vomiting, general emaciation, debility, and coma. After death, stomach and intestines were found very much injected. According to Hertwig, large doses augment the secretion of intestinal •"ucus and procure abundant and semi-fluid dejections, but do not destroy the appetite (which smaller doses even stimulate). Very large "Wes arc said to cause inflammation of the gastro-intestinal mucous "membrane, which, however, is superficial, and unattended with any "iolent symptoms. (Stille, op. cit.)

1. Three dogs which I had placed, at the same time and in the Wme conditions, under the influence of the tinct., had all from 3rd to 4th d, paroxysms of cough, which were reproduced at once by pressing ""Itrynx or trachea ; from 4th to 5th d. dyspnoea in addition to the Cough, which itself became more intense ; on 6th traces of crepitus at o»5cs of both lungs, violent fits of coughing, taciturnity, dulness, ptostnuion. In course of 3 following d. there was at first an increased

intensity of the crepitus ; which afterwards, however, quickly disappeared, and recovery from this artificial disease ensued, notwithsunding the continuance and even increase in dosage of the drug. (Andrieu, loc, at,)