Volume I — Main text

AGARICUS.

Agdricus muscarius^ L. Bug-agaric. Nat. Ord., Fui^.

Provlngs, — I. Hahnemann, Chronic Diseases. Part 11 of original, Vol. I of translation. Contains 715 symptoms from self and ten fellow-observers.
Ohlhauth took a few drops of ix dil. : after J h., while standing reading the paper, he noticed the paper moving with the beat of his heart ; pulsations were as distinctly felt and violent as in climbing a mountain. Next day, after 7 drops of ist cent., same symptoms recurred. (HygeOy xviii, 19.)
Kretschmar smelt at agar. 6 for 5 m., and when walking in open air, in coqI summer weather, he felt burning and itching on ears and cheeks, also on both hands, as though they had been frozen and been affected by the winter's cold (he had had these parts frozen in infancy). On rubbing felt heat and swelling of those parts, and they cot very red. This symptom continued to trouble him for four months, it lasted longest in hands, which in the cold autumn days, after long rubbing on account of the intolerable itching and burning, swelled to such an extent that the joints could not be distinguished {Allg. h. Z. ii, 62J.

4, Lembke took 31st Jan^ 6.45 a*m., 10 dr. mother tincture.

7 a.m. Pulse fell to 60 then to 54, equable, full, soft. Stitch in

apex of heart. Feeling of exhaustion in legs, drawing and formication

beneath skin on front of legs and towards internal side of sole* Heavy

and confused head, resp. 15 perm. Stares before him without thought,

weary, 7.5 a.m. Pulse 65. Sleepy, yawns and stretches. Slow and

Lizy, indisposed to think, Very weary in all limbs* 7,30 a.m. Pulse

In knees especially, a sort of internal trembling and powerlessness

in legs. Great desire to sit in an easy posture. Inward chilliness and

cool skin. When walking, very tired and disinclined to go on. Head

heavy, call to urinate. 745 a.m. Pulse 70, Horripilation over hairv

part of head. Respiration difficult* Flow of thoughts easily disturbed,

and not readily recalled. Severe tearing over anterior surface of 1,

ankle-joint. Sinciput heavy and full* Much flatus discharged. Aching

and bruised pain in elbows, esp. K 8 a.m. Pulse 65. Yawning

and great chilliness. 8.15 a.m. Pulse 60. l*he urine passed after

much solicitation at 8.30, normal. Pulse 57. Urgent call to stool and

some rumbling. Occasional chill through back and limbs. Resp.

attended with an effort and superficiaU Sometimes warm sweat in

palms. Frequent call to urinate. 8.45 a.m. Pulse 60. Some drawing

in lower part of L leg, 9 a.m. Pulse 5*S. After stool, during which

urine was passed, immediately a fresh call to urinate, 1 his frequently

happens afterwards. Slight chilliness when moving and in cold air, or

when the cold fingers touch a warm part of the body. 9.15 a.m.

Pulse 60, 9.45 a.m. Pulse 65, Much chilliness and constant cold

hands and feet, yawning, frequent call to urinate, exhaustion, and dislike

to movement. Rumbling in bowels, and fixed pain deep in umbilical

region, increased by pressure. From 10 a.m. till 2 p.m., occasional

pains in J. side of head ; frequent call to urinate ; while sitting, violent

shtx)ting in r. lung, causing him to hold his breath, relieved by pressure

of hand on chest. Noon. Good appetite, 2,30. Stool with much urine.

In K thorax superiorly, pain in intercostal muscles. Drawing pain hi

elbow. 4 30 p,ni. Painful aching in lower external front of 1. thigh

down into knee, then in 1. sole. Tearing in r. occipital bone. Drawing

in 1. toes. The symptoms seem to increase in room and during rest*

f Repeated stitches in r. lung when sitting, making it impossible to draw

■breath, somewhat relieved by external pressure. 6 p.m. Tearing in

muscles of anterior lower front of r. leg. 9,30 p.m.- — ist Feb. Woke

carJy (4.30), thereafter half-sleep, during which constant pressing pain

in umbilical region, which did not quite wake him up. 7 a.m. Much

rumbling ; feeble call to urinate j call to stool. Dull drawing pain in

abdomen going towards lumbar muscles. Jerking shoodng in r. lung,

8 a.m. Stool as usual at 9 a.m. — 2nd, 5,30 a.m., 25 dr. tinct. Sudden

running through 1. forearm, which fixes itself as a pressing pain at the

l^ase of the fingers. Heart's beats felt more distinctly and strongly.

sudden pain in middle of back, 5.50 a.m. Pulse 80, soft, small Fine

[looting in cardiac region. Drawing pain from 1. upper arm to forearm,

)rawing in 1. inner ankle, 6 a.m. Pulse 60, soft, small. In K leg

about the knee, internal drawing and trembling. Crawling under skin

ill L ankle. Painful drawing in muscles of 1. forearm and over elbow*

I+O

In sinciput weight and confuston. The candle seems to bum mo dimly* Pressure deep in head in front, at limit of hair. ShQotin|^ in muscles of anterior wall of r. aseilla. Heat of head ; like distant roaring or ringinc; in cars (like a distant water-kettle commencing tfl boil}. Pulse 70^ fult, large. 6«tS a.m. Skin very warm^ blood-ve$9e1s| greatly distended. Drawing in I. tibia when walking* Peculiar fceltii_ of weariness and stiftncss between shoulder and towards nape. Finc^ pricking behind sternum. Call to urinate* Shooting in 1, sole. Deeper breathing. Tearing in bones of r. side of head. Bruised paia in extremities, especially lower, removed by walking. Much yawning ~ (though he had slept well at night)* Oppressed feeling in chcsr, cor pclling deep breathing. Creeping and pressing in L calf. Peculiar dull shooting from r. hypochondcr and navel to sternum* Much rumbling in bowels. Internal chilliness and cool skin. Sinciput confused asl if pressed in. Eyes sensitive to candle light, inclined to shut thenv Creeping in dorsum of I. foot. Weary in knees. When walking through room great exhaustion and wish to shut the eyes ; dccf breathing. 7 a.m. Pulse 70. Constant desire to urinate. Shooting outwards from L nipple^ more in the muscles apparently. Constant pressure on upper part of chest like oppression, with repeated decc breathing when walking and sitting, with painful pressure behinJ sternum, and on both sides of it, coming and going, with feeling weight in chest. Fine shooting in 1. calf ^ unne normal. In stomachH constant pressive sensation. 1 eanng in L occipital bone. Drawing and pressure in 1. intercostal muscles, in muscles of 1. thigh, with bruised feeling of 1. elbow. 8 a.m. Pressing pain in lower pan of L leg when walking. Stool and much urine, followed immediately by renewed call to urinate. The tightness of chest, deep breath* ing, stitches behind sternum, and the peculiar pressure on sides of sternum, continue even when seated. 9 a.m. Peculiar constant dull pressure deep in pit of stomach. Internal trembling in r. forcartri to head. Bruised feeling in sacrum. Great sensitiveness to cool air. 9.45 a.m. When walking shooting in r. lung* Frequent call to urinate. Noon. When sitting the above-mentioned chest symptoinjJ recur, especially behind r. border of sternum, where the pain is increased* by inspiration. 2.30 p.m. W^ hen sitting some irregular strong hearths beats with feeling of oppression. Shooting in r, pectoral muscles* Pressive pain behind sternum. Drawing in L wrist. Shooting in 1. pectoral muscles j drawing in r. foot i boring in sinciput. Occasional oppres* sion of breathing. Shooting in I. lung between fifth and sixth ribs, especially by breathing, 4 p*m. Anxious feeling of oppression in heart with irregular stronger beats. Boring in r. cranial bones and In ascending ramus of r. lower jaw. Soon after dinner (2 p.m.) and later great hunger. Shooting in middle of r. lung, increased by every breath drawn. 5,30 p.m. AH day weary and heavy in legs; quantity of unne passed increased. — 3rd. Towards m. many cheerful dreams about acquaintances, and when lying on 1. side (his usual position m sleep} an acute pain in apex of heart, which, however, does not quite wake him up. M, Slight pressure behind sternum. Stool delayed, hard^ scanty. Little hunger all d. Less urine passed during

A, — 5th^ 545 a.m., 60 dr. tinct. Weight in 1, leg like lead. Crcaksng of many joints when moved, lasting Jong. Constrictive pressive pain in I. elbow and r* shoulder. Pressing and tearing in I. cranial bones and in crown. Creeping J ike ants in tips of 1. toes. Pulse 57, soft, small. 6 a.m. Slight chilliness on slight movement. Tearing in bones of sinciput. Heavy and full in sinciput. Itching^ creeping in skin of ]. sole. Bruised feeling of limbs, especially lower ones- Frequent deep breathing. Like small jerks in muscles of 1. shoulder and betwixt scapulaj. Frequent yawning. Slight walking tires much. Shooting in r. pectoral muscles. Constant rumbling in belly, eructation of tasteless air and emission of flatus. When sitting the bruised pain and weariness are greatest. Eyes narrow, and shooting in border of lids as when very sleepy, with sensitiveness to candle light, 6,30 a.m. Involuntary closing of eyes. The edges of lids and conjunctiva lining them are redder, with shooting and tension. Feeling of weight on chest and deeper breathing. Internal chilliness frequently, mcreasing later on. Drawing pressure behind r, edge of sternum. Tearing in r, ankle-joint and r. knee, and dull drawing in upper incisor teeth, after exposure to cool air. Fine shooting in 1, lung. Peculiar drawing and aching on the back parts of roots of upper L teeth, including incisors. Till 7 a.m. pulse 57 — 60. Urgent call to urinate. Small jerks in lumbar muscles. Smarting sensation in mucous membrane of I. nostril. Slight exertion tires much, out of breath and bruised pain in anterior muscles. Continued pain deep in umbilical region. 7.30 a.m. Pulse 58. On taking a deep breath feeling of movement, almost shooting, in pectoral and cervical muscles. Stool with much urine. Tearing in various parts of cranial bones, 8,15 a.m. Pulse 70. Call to urinate increased. Bruised pain of some joints, but not so severe. Feeling of stiffness in tendones AchiUis when rising from seat. Very great hunger. 9 a.m. Shooting in r. lung, in several parts, momentary. 9.45 a.m. Urine straw coloured. More or less violent pressive pain in umbilical region, sometimes rising up into r* side of chest. When walking slowly in open air much flushing of heat over back, twitching in face 1. side. Anxious feeling in heart, and some stronger irregular hearths beats, which increase that feeling when sitting at 12.30 p.m. j this is repeated an hour afterwards. Stitches behind sternum hindering breathing. 2.30 p.m. Stitches on 1. side of chest, between nipple and sternum, increased by every breath drawn ; pulse 90, full, hard. 3 p.m. Stool and much urine. Peculiar bubbling sound in r, car, frequently repeated. Tearing in various parts of cranial bones. 4 p.m. Pulse 85. Here and there painful aching in limbs. More or less severe tightness of chest, with occasional deeper inspirations and more distinct heart's beats, and a kind of oppression, especially behind both edges of sternum throughout its whole length, also later. 5 p.m. Pulse 84. — 6th, 9 a.m., stool and much urine. All day more inclined for work and more cheerful than yesterday. More and more frequent urine, Several times oppression of heart when sitting quietly, and stronger heart's beats. Appetite small, chiefly for bread and butter. E. When sitting sudden stitches deep in chest close to dorsal vertebra;. Repetition of the bubbling

noise in r. ear. — 7th and 8th. Sometimes shooting in one 01^ odierlung, especially when leaning forwards or stooping down ; sleep short, uneasy dreams ; stool regular. During the d. occasional shooting behind edges of sternum, and heart's beats irregular, stnm«r, and as though jostling one another, following a cessation of die hemit^s beats, combined with oppression, only when seated.— 9th, 6.15 ajn., 2 drachms of tinct. Skin cool, but veins swollen, more ao later on. Creeping in 1. toes. Repeated bubbling noise in n ear. Bruised pain in 1. elbow and ankle-joint. Drawing mnd prrsiin^ in several muscles of extremities ; pulse 80. Sensitiveness of ejca to candle light. Slight nausea. 6.30 a.m. Pulse 6o. Pressive pain in aoiise muscles of extremities, quickly coming and going, chiefly in CTtffnf1^r muscles. After 5 m., pulse 65, irregular in rapidity. Tearingin Ittmhar muscles when walking and sitting. Pain in 1. shoulder-joint. Sttccbes in orifice of urethra. Much urging to urinate. Deeper breathing. Tearing in cranial bones, more 1. side. Bruised pain in L fingers, chca in extensor muscles of 1. leg. Smarting and narrowed feeling in eyelids. 7 a.m. Pulse 60. When sittine the muscukr sjrflBptoms increase ; they are slighter when walking. Jerking, drawing ana pressure here and there in muscles of leg. Slight shooting in base of L lung. Pulse sometimes as if double with a snort after-beat. Pain in L intercostal muscles beneath shoulder. Respiration superficiaL Much yawning. When sleeping oppression in heart and stronger hevtfa beats. 7.15 a.m. Pulse 60, unequal quickness. Bruised pau in npper arms. Tearing pains in pit of stomach. Great noise of air and Kid in bowels. Flow of saliva. Till 7.45 a.m. pulse remains 60, of unequal rapidity, several slow full beats, then some rather quicker and less fiiH. Pain in bases of r. fingers. The pupils, which were at firrt contrKCcd^ became afterwards visibly and persistently dilated. 8 a.nL Plain in dorsal muscles when seated. Pulse 65. 8.30 a.m. After long-oontinued urging to urinate, much urine passed and a soft stool. Perustent pain deep in umbilical region. 9.30 a.m. Pain along edg^ of ribs fiom back, encircling the body, worst when walking and standing, hindering respiration. When walking shooting in r. lung,. Shooting behiiM sternum not increased by inspiration, but worst at end of expiration. Great urging to pass urine, which scarcely ever leaves off. 12.30 p.naL No appetite^ though has eaten nothing. When sitting, tearing in I^^} shooting in 1. lung. When sitting, oppression in heart with some stronger beats. Tearing in cranial bones, on 1. posteriorly. Increased pulsation of heart felt inwardly. Twitching pain in bladder. 3.30 p.ai. Pain in some muscles of extremities. All afternoon very drows^M-— loth. On rising in morning, stiff pain in r. biceps when bending ton* arm, lasting a long time. Forenoon. Frequent micturition. During the day little appetite. When at rest oppression behind sternum, and some stronger heart's beats. Two softer stools during day. Piofiiae perspiration whenever he walks. Much thirst for cold water since nooiu Afternoon. Urine scanty and dark coloured. On two different eveniogs has the following ; when going to sleep an electric shock with twitching through legs, chiefly the 1., and sudden complete waking, thereafter slept well. — nth., m., when sitting, inward drawing from pffilvic

muscles to leg, which passes into outward trembling, with very warm skin, slow pulse. Sometimes slight pressure in various joints^ and slight tightness behind sternum. {j^Hg- h, Ztg.^ xlvi, 6, 25 ,)

Dn Adler, 3et, 39, small, thin, black haired, sanguine-cholcric temperament. Healthy, only suffers occasionally from hereditary haemorrhoids.

&n Proving of agar. 2,. — loth Sept. 100 drops i h. before breakfast. In i h. had full feeling in umbilical region, later pressure in stomach as from accumulation of flatulence, bymptoms all went off before breakfast, but \ h. thereafter pressivc pain and down-drawing in stomach, relieved by discharge of much wind. — iith, 200 drops tTi« fasting. Immediately nausea with inclination to vomit and aching on r. side of larynx, with cough irritation. Soon afterwards quite well. \ h. after breakfast on taking a draught of cold water painful jerks in a loose tooth in lower jaw. This symptom recurred several times m \ h. on drinking cold water. About 10 a.m. transient vertigo with pressive frontal headache. — 12th, 6 a.m., 300 drops. Soon pain in sinciput as if forced together from both sides, and feeling in belly as if about to be purged. About 8 a.m., shooting pain in r. temple above eye. On drinking water jerks in teeth as before. About 8.30 a.m., transient vertigo, 12, noon, spasm in stomach, urgent call to stool, which was copious, and could scarcely be kept back ; just before had painful pressure on rectum anteriorly, i h. after noon meal prostration and weakness of lower extremities ; stitches in r. calf, burning in rectum, and inflamed piles, E. Burning and itching on sternum, whereon were some pustules the size of a millet-seed with red areola. Sleep at n. much disturbed. — 13th. Woke at 4 a.m. m cross temper, with transient shooting pain in head going from L parietal bone to r. temple. Immediately afterwards pressure of flatulence against navel, lasting some m, \ then momentary shooting pain in r* eyeball.

b. Proving of mother tincture. — J 4th, At 7 a.m., fasting, 4 drops of mother tincture. Immediately transient boring and pressure in stomach. 15th. — At 7 a.m., 5 drops. Thereafter empty eructation. • 4 h. afterwards nausea on drinking cold water. 3 h. after breakfast violent pinching in umbilical region for a f^v/ seconds. — 16th. At 7 a.m.^ 10 drops. Pressure in stomach for some seconds, — 17th. At 6 a.m., 20 drops. Immediately a stitch \n r. temple, then a stitch in 1. temple, followed by slight pressure in the latter, lasting some m. ; at same time great rumbling in belly. In J h. tearing drawing pain in r. upper maxilla and r. cheek, lasting some seconds. At 7 a.m., pressive pain in frontal region, and frequent empty eructation* 2 h. later painless twitching in r. masseter muscle like a jerking for some seconds. In afternoon heavy feeling and invincible drowsiness. — 18th. At 6 a.m., 30 drops. About 9 a.m., vertigo, 930. Pressure and drawing in stomach, increased by pressing on it with the hand j forcing below the navel. 945* Shooting pain in r. frontal region. About 5 p.m., needle pricks in L thumb, aggravated and also excited by slightly touching ; painful lameness of r, upper and forearm, and slight fatigue of the latter on writing but little. Before midnight pressure in chest

and difficylty of breathing.— igth, 6 a.ni,^ 30 drops. Frequently during dp attacks of anxiety, then oppression of breathing, compelling frequent deep breathing, — 20th. 40 drops. About i p.m., pncssivc pain in r, eyebrow and burning in fauces, the lower surface of tongue on the r. sore and burning in several spots j the sore spots looked shaggy. About 5 p m., transient twitching in r* side of head. On lying down at n. several blows in the heart and trembling in scrobiculus cordis with anxiety, caused oy every little sound, also on waking in m, accompanied by stitches in umbilical region, frequent sneezing and yawn* ing. — 2ist, 40 drops. About 11 a.m., painful n ess of 1. maxillary joint, aggravated by touching. About 2 p.m., shooting tearing in horizontal branch of lower jaw. — 22nd. On awaking at 5 a.m., itching in borders of eyelids and considerable frontal headache. About 7 a.m,, 45 drops. Then anxiety of chest and frequent sighing. About 9.30, stupefaction and drowsiness, betier in open air, N. spent in restless dreams and half-slumber. — 23rd. 50 drops. Immediately pressive pain in r, eyebrow, relieved by washing the body in cold water, hut then becomes worse. After J h. stupefaction and vertigo, gnawing in scrobiculus cordis and pinching in belly. About 8.45, pressive frontal headache. About 10.30, understands what he reads with difficulty, though it is quite easy j reads with difficulty, because the print seems to move. In both eyes itching and burning. Great drowsiness. — 24th. 60 drops. I h afterwards as if a pressive pain round about the whole head ; at same time pressive pain in 1, eyeball. About 8.30, forcing in I, groin and pinching in belly, lasting some m. Thereafter pressive pain in L eyebrow for 5 m. ; immediately thereafter transient pressive and shooting pain in r. eyebrow. About 10 am,, twitching and shooting in r. temple and along zygoma. In the room vertigo, less in open air, but soon returning. 10.30 a.m. Stitches on 1, side of hairy scalp, passing into pressive pain in crown. Piles highly inflamed and painful since yesterday. 6.30. p,m. Pressive pain in 1. eyebrow. Woke at midnight with pains in stomach, as if flatulence pressed outwards* After discharge of much foetid flatus the pains went off, (Three successive nights woke precisely at midnight.) — 25th, 6 a. in,, 60 drops, 9 am. Pressive pain in L eyeball, lasting J h. During the day slight vertigo. Woke at 2 a.m* with blows and aching pain in r. ankle-joint, then a very tiresome sensation in heart as though it were constricted, going off gradually in j h. — 26th. On waking at 5 a.m. vertigo and tightness of chest that lasted almost all d. Violent burning in piles. Woke about every j h, in the night, — 27th, m., violent forcing in the rectum after copious stool. Discharge of several ounces of bright red blood from rectum, with tenesmus, (Has had no ha^morrhoidal flux for years.) During the d. drawing pain in forehead to the eyes, going and coming. — 28th, m,, on waking twitching in 1. eye. — ist Oct. 80 drops. Noon* Pressive and drawing pain in forehead, eyes and occiput ; pressure in stomach, with frequent inclination to sigh. After noon meal uncommon drowsiness; drawing pains in head all the rest of d. — 2nd, m., pressive pain in r. eyebrow. No further symptoms till 6ih, when had in m, on waking out-prcssive shooting pain in I. eyebrow, and

that n., about i am,, transient blows in heart with anxiety, and transient burning in orifice of urethra. No further symptoms. [Ztitichr. dfS Ver, d, horn. Jerzte Oisterreichsy ii, 1863.)

6, Mr§. Adler, aged 29, since her confinement, nine months ago, very irritable ; is stout, blonde, health good, catamenia always regular. 14th Sept* took 100 drops of 2^ aqueous dilution of agar. Immediately rumbling in belly, and pressure in sacrum for a few seconds* Then weight in scrob. cordis. Slept well at night, but awoke un refreshed, with heat and heaviness of whole body. — 15th, 200 drops. In \ h. severe shooting in r, side of head \ later, shooting in whole head, worst on both sides of head, accompanied by stupefying vertigo, lasting \ h, Catamenia came on at night two days too soon. At night restless Jeep, constant tossing about owing to a tiresome shuddering in the i^hole body, as also in head, chest, abdomen and feet, i a.m., woke with violent tearing pain in all the upper teeth, lasting J h. On waking in m., drawing pain in r. sinciput, palpitation, and the same heaviness in body. — i6th, 7 a.m., 200 drops. 7.45 a.m., violent vertigo, must sit down often. No appetite for breakfast, 8 a.m., when sitting down on account of vertigo, suddenly a violent headache, pressive, extending into 1. car, soon followed by shooting pain in r. side of head. This headache continued more or less all d. 11 a.m., spasmodic contractive pains, from the scrob. cordis to deep into belly, with nausea, all lasting some minutes, then empty eructation alternating with three violent hiccups, 2 p.m., tearing pains in 1. upper arm and lower teeth, with similar tearing or violent itching in L ear, causing her to bore into the ear. When she lay on the affected side, the pains were aggravated \ they lasted all afternoon with nearly equal violence till e., when they became better. Catamenia more profuse than usual, with violent tearing and bearing down pains in abdomen and back. Very cross, answered unwillingly. Dislike to work, ran restlessly from one place to another, though very fatigued in limbs and prostrated. E., a copious, soft, greenish stool. Twice, afternoon and e,, attacks of ihuddering all through body, several times palpitation of heart, water ^frequently rose into her mouth. On lying down at night, violent itching betwixt 1. index and thumb, also in r. side of nape, and pustules the size of poppy -seeds appear on both places. Intolerable itching in external genitals lasting till next d,^ — 17th, m,, stupefying headache all forenoon. 1 1 a.m., difficulty of breathing m cardiac region with palpitation. Afternoon, a dark green fiuid stool j catamenia increased last night, restless sleep, waking frequently on account of violent drawing and tearing pain in teeth and sides of head y the little sleep was full of vivid dreams, — i8th, m., dull headache with stupefying vertigo and palpitation of heart, somewhat relieved by getting up, but soon becoming more violent, with frequent chilliness ; catamenia declining. Cross with herself, and sorry for herself j face pale and sunken, feels very prostrated. '^clt as if the whole body was wasting away. Thi,i weakness and prostration on the slightest exertion, with palpitation and stupefying headache and vertigo, and the restless sleep with anxiety, lasted more or less for eight days, and alternated with on^ another, (Z^'W.)

with vertigo lasting and burning pain

7, Rosalie A — , aged 60^ single, no catamenb for firtccn yeariflodt both eyes in infancy from ophthalmia. Enjoys good health. Brunette, black hair, sanguine temperament.— 14th Scpt.^ too drops of agar. 2* (alurays took the drops 2 h* after breakfast). In i h* rigor all over, with goose-skin, lasting l m. Never had anything like it before. —15th, 200 drops. In ^ h. violent rigor with goose-skin, then heat in head, with painful throbbing in frontal region and sweat on forehead, soon passing off, — i6th, 300 drops. In ) h. some stitches in hepatic region j next n. intolerable noise in both ears like that of a spinningwheel, lasting several h. — 17th, lo drops of tincture* In } h. burning in 1. eyebrow near temple^ and creaking in 1. occiput aggravated by pressure, lasting J h. At same time deafness of 1. car, as if something lay before it. Some vesicles on hard palate, with sore pain In them. •^i8th, 15 drops. In i h. violent burning pain in 1, eyebrow and occiput, with sensitiveness to touch ; great general weakness. All lasting i h, — 19th, 20 drops. Soon violent shooting and twitching in 1, eyebrow, shooting in 1, axilla and ribs of 1. side. In i h. nausea and great weariness ; salt taste in mouth as from herring ; then warmth streaming through the whole body, — 21st, 25 drops. In 4 h. pinching in belly, scraping together in upper abdomen, stitches, then cutting in it, followed soon by violent bitter vomiting. — 22nd, 30 drops. In 4 h, frequent empty eructation, then vomiting of a bitter fluid. Immediately afterwarcls in-pressive pain in forehead, then painful twitching in r. eyeball i soon afterwards tearing in 1. thigh and calf, burning in stomach. — 23rd, 40 drops. In | h. belching of a salt fluid, then stitches in 1. temple and sacrum, and soon after clawing in scrob. cordis, as with pincers. — 24th, in i h. bitter vomiting with shuddering all over the body, then transient stitches in rectum and r. lumbar region. Then pressure and twitching in forehead to the eyes, for } h* Then transient itching and sharp smell in nose, as though she would sneeze. — 25th, no medicine. During the day frequent stitches in liver and r, lumbar region j pressive frontal pain all day. — ^26th, 30 drops. In 2 h, burning on crown with stupefaction and vertigo, she seemed to be turning round, so that she must quickly sit down on floor, otherwise she would have fallen. This vertigo lasted 2 h,, along with it were nausea, shooting in liver and scrob, cordis. AH day could take no food. Next day well except slight pressure in head, [Ih'tdJ)

J. Baumgartner, aged 32, sanguine-choleric temperament, thin, subject to boils in different parts of the body, and a purulent discharge from r. ear, otherwise well

a. His first provings were with dilutions made with 10 drops tincture to 80 alcohol. — 24th Oct, Began with 8th dil. and descended gradually to the ist, taking each dilution for 3 d., 100 drops every morning, and leaving a d, free between each dilution. From 24th tu 29th no symptoms. — 30th (7th diL), Transient tearings in the fibrous expansions of different parts of the body, especially the outer aspect of the L thigh. Since yesterday a pain on touching between eighth and ninth dorsal vcrtebrse ; to-day there appeared on the same spot a painless pulsation, beating downwards, synchronous with the pulse| as though the aorta were in the spinal cavity* This sensation

liasted more than one hour, and was relieved by pressure* — From 1st to r3rd Nov, (6th diK). Each time after taking the drug, pain in sacrum and increased flow of saliva into mouth, firmer stools. After noon meal inclination to vomit, without loathing of food, cutting searching pain in bowels, prostration of the bodily strength and inability to think, with internal restlessness that drove him from one place to another. At same time, feeling in head as though the frontal portion of the skull were enlarged and the brain there all stirred about, with pressive pain in both temples, dryness in gullet, yawning, and a painful sensation in fauces when swallowing saliva, as if something were torn* — 4th, Boring pubating pain in squamous portion of temporal bones, lasting more than 2 h. — From 5th to 8th Nov, (5th diK). Firmer stools, the superciliary prominences are painful when touched, tenderness of the eyeballs, with constriction of them. The region between eighth and ninth dorsal vertebra is painful on turning the body. In morning increased appetite, break^st can hardly be waited for. A painful suppurating abscess, the si^e of a bean, has formed in the middle of the r» deltoid muscle. In the fibrous expansions of the extremities there occurred occasional transient tearings j in abdomen sometimes cutting pains with discharge of inodorous flatus, increased secretion of saliva and inclination to vomit. This last chiefly in the room, went off in the open air ; at same time deficient thirst, chilliness in open air, and a pulsating pressure in the nasal bones, with sensation as though a swollen body in the ypper nasal cavities would force itself out, E., increased heat of face, especially about the zygoma, dryness in throat, and flying stitches there on being touched. — From 9th to iith Nov. (4th dih). Painful pressure in eyes on moving them, and straining them by candle light. — 12th. The pain betwixt eighth and ninth vertebra? recurred, it was drawing, and periodically extended to hyoid bone. After dinner inclination to vomit ; the I, big toe, at the depression of the nail, is swollen and very painful. — From 13th to 16th (3rd dil,). Along with transient tearing and spasmodic contraction of the 1. glutceusmaximus, there occurred increased painfulness of the spine on turning the trunk, great dryness of the gullet, earthy taste, eructation, and obtuse pains, now in one now in the other frontal protuberance. — From 17th to 20th (2nd dil.). Empty feeling of head ; disposed to quarrel, with great weariness of lower limbi, as if lead hung on to them. In the fauces a sensation as if some food had stuck there. Breathiug interfered with by momentary stitches in cardiac region, with irregular, often intermittent, pulse. A cold sensation frequently in the glutaei muscles. — From 21st to 24th (ist dil.). Frequently felt tearing now and again in the fibrous expansions of the body, that of the skull not excepted, with uncommon weariness of lower limbs when walking, so that he must often sit down j at same time pain in sacrum and great drowsiness ^ the feeling of a foreign body in the fauces compels frequent attempts to swallow, which are as inefl^ctual as troublesome.

i, Proving with tincture ^. — 25th Nov., 20 drops. Stitches in 1. heel on treading, which extend up the leg ; tension in the gastrocnemii j transient stitches in 1. hip-joint, and a stretching pain in the articular cavityias if the bone of the cotyloid cavity were severed from the sacrum.

This pam spread to the lower abdominal cavity, and then disappeared gradually. — 26ih, 7 a.m. ^o drops. Fulness of head, with a stirring up sensation as though the brain In the frontal region were an ant-hill ; cutting boring pain from the K anterior nasal orifice upward through the nasal canal extending into the nasal bone, just like an electnc shock. Two small stools with slight burning in atvus and discharge of cadaverous smelling flatus, at same time occasional transient tearings from behind through the chest without disturbance of respiration^ and stitches in 1. knee lasting several seconds, followed by weak feeling of the limb. — 27th. During a walk — in consequence of a jump — a burning, shooting, dislocation pain beneath r nipple, which prevents respiration for a few seconds. 4 p,m., great weakness of whole body 1 anxiety with breaking out of sweat, violent stitches in cardiac region, with intermittent pulse ; at same time loathing without vomiting, and raging pain in r. hough, — ^iSth, 7 a.m., 50 drops. No cBect. — 29th, 7 a.m,, 100 drops. Soon empty feeling in head, dryness in throat, which was not moistened by swallowing saliva | inclination to vomit and once actual vomiting. The inclination to vomit continues after the vomiting ; at same time great weakness, uncertain gait, stumbling over every object j pressure and heaviness in chest ; involuntary sighing with accelerated heart's and pulse's beats, constant spitting of saliva, dry cough, which causes shooting pains in 1. side of chest ; rumbling in abdomen as if peas were shaken about in it ; frequent quite soft stools, the call to which had to be quickly obeyed on account of paralytic weakness of the sphincter ani, feeble sexual function. Along with these phenomena there was a very acute pain at the twelfth dorsal and first and second lumbar vertebra, with cold feeling in the glutaei muscles, and formication on the feet, — 30th. Vacant feeling in head, indifference to the world, apathy in business, great dryness of the throat not removable by water or beer ; a tiresome pressure in the fauces as if a foreign body were sticking there, which cannot be removed by swallowing ; shooting burning pains from scrob. cordis to K scapula, excited by deep breathing, and very much aggravated by coughing, sneezing, and hiccup ; violent pains in spinal column on turning the body, especially in the region of the last dorsal and first and second lumter vertebrae, which became pulsating after strong exercise. VVeakness in sacrum, with pressive tensive pains in it. Cold feeling in glutsi muscles, which are spasmodically contracted and hinder waking. A shooting tearing now and then in the limbs on commencing to move, but going off on persevering j powerlessness and weariness of the whole body, — 6th Dec. Head vacant, vertigo when walking, whfch makes the gait unsteady, tender gums ; dryness of throat and sensation of a foreign body less, but roughness of voice with shooting pains in larynx on drawing a deep breath ; weight and shooting pain in chest ; quick pulse, intermitting every 30 to 40 beats ; fluent coryza ; several soft stools causing burning at anus. — 10th. Cross and irritable, with vacancy of head, full feeling of upper nasal passage, with sensation as if a ball wanted to come down through nasal canal ; pressive pain in sacrum as if it would burst, formication in feet, strong pulsation of heart felt down to the coccyx i quick pulse witb painful stitches in cardiac region, with

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great heaviness and weariness of lower limbs. All the symptoms, except the weakness, gradually declined to 14th Dec.^i5th, 9 a»m*, I jO drops. Soon afterwards he went out to walk, but whilst walking was seized with such weakness that he could scarcely go on ; then there occurred four liquid stools with burning in anus, profuse perspiration all over the body, even on the hairy scalp ; pulse at same time quick and small On the hairy parts of occiput and along sagittal suture, small elevations appeared, which burned and smarted after scratching. During day, three more diarrhceic stools, with swelling of haemorrhoids, and a strong forcing downwards of the bowels into the inguinal canal and pelvic cavity ^ after urinating the urine flowed on involuntarily for some time, so that the thighs and knees were often quite wet ; it seemed that the sphincter muscle of the bladder refused to do its duty ; at same time pressure in sacrum as if a weight lay on it, formication in glutsei muscles, and a coolness running down from the legs to the toes ; sexual power almost extinguished. These symtoms gradually declined till the 25th Dec. The pain in sacrum sted longest. — 26th, 9 a.m., 200 drops. Immediately inchnation to Ifomit, but not actual vomiting. The other symptoms were like the ^bove, except a feeling as if the head were enlarged, and a cough attended, in the morning especially, by expectoration of large brown masses of mucus. — 30th, i p.m., 300 drops* Soon slight burning in stomach, with loathing and heaviness of lower limbs j afterwards great drowsiness. At i a.m., sudden waking with ill-feeling and inclination to vomit, he had to get out of bed, and with great effort vomited several times undigested food. The pain in the fauces, as from a foreign body, was aggravated during the vomiting ; after vomiting felt as if 1. eyeball were enlarged. Constant salivation causing him to spit incessantly, great weariness, especially of the lower limbs, with trembling of them ; insensibility and coldness of glutsei muscles. Constant twitching movements in sacrum and lower extremities, coldness of all the body with hot head, at same time as if destitute of senses and thought, followed by severe rigor all over the body, — 31st. Had to remain in bed, he felt so weak. Severe headache that diminished in the c., and was confined to the forehead j pressure on root of nose, with feeling as if nose were stopped, which it was not, with dryness of throat , loathing, though the taste of food and drink was all right i shudder spreading from stomach over the body ; swelling of haemorrhoids with stitches in anus ; sometimes violent shooting pains in rectum from flatus pressing down to the anus, and then seeming to make a backward movement in the pelvic cavity. Cough increased towards evening, quick pulse = 100, intermitting. Painless pulsation in spinal cavity. In back, sensation as if a cold air spread from spine over body, Fullness and pressive weight in sacrum, shooting pains in fingers and toes when at rest, creaking and cracking of them when moved, shooting pains now and then in general integument. — ist Jan, Many of the above symptoms declined or disappeared, but in their stead there came on a peculiar change in the urinary secretion. When the need to urinate came on, the sphincter muscles had not the power to retain the urine for a moment, it flowed out in several gushes, with

fSO

long aftcr-dribbling which wets the thighs ; the penis was cold and shrivelled. These symptoms gradually went off till 9th Jan. — loth,

9 a.m«,400 drops, rressive pains in 1, frontal protuberance, a stirringup in brain, as if all there were moving about ; confusion of thoughts with forgetfulness, weak sight, tearing in L lower jaw, hiccup in throat j griping in bowels j frequent liquid stools with burning in anus; paralytic weakness of sphincter ani and vesica?, so that the fseccs and urine could only be kept back for seconds. Pressure in sacrum and hip-joints, especially in m. in bed^ sometimes a sensation as if the painful head of the femur were separated or dragged from its cotyloid cavity, or the pelvic bones from the sacrum. Burning in glutaei muscles, salivation and formication in upper and lower extremities ; great weakness of body, dry cough with wheezing under sternum, causing burning, accelerated hearths beat, with redness of face and tickling in the navicular fossa of the urethra, as if some foreign body were lodged there. Burning of tongue as from pungent tobacco, shooting in the second and third row of the ankle-bones and heel when walking, ill-humour and irritability, long, gentle, refreshing sleep. {Ihtd.)

9, Joseph Copainigc, medical student, aged 23* choleric temperament, venous habitus, generally healthy, but suffer* from tapeworm.

1st d., 8 a.m., 5 drops tinct. agar. 9 a.m., tension in |>pelvis and hypogastrium, transient griping recurring after short intervals, always commencing with a stitch, and gradually going off. From 9 to

10 a.m. The griping always more severe and more frequent, the stitches commenced in the pelvis, spread thence to the r. side of abdomen, along the iliac region to the r. hypochondrium, growing weaker in their passage, and at last going off completely. Tension in the whole abdomen, very disagreeable humour. From iotoiia.m. pain in abdomen gradually declined, tendency to vomit, stomach felt full and as if seated just below the oesophagus, so that only the slightest effort would be required to vomit. In order to avoid this, he must cease smoking tobacco. Head very warm, dull drawing pain in middle of forehead betwixt eyebrows ; heat and weariness of ^eyes^ the eyelids every time they are shut leaving a burning feeling, just as when he has sat up all night by candle-light Great weariness of all the body ; illhumour, melancholy disposition ; indisposition to all work. From 11 to 12 noon,, cessation of griping in belly' ; head full, confused ; dull, rather severe, pain along forehead and sagittal suture ; constant heat iti ^y^^ \ frequent yawning ; weakness of whole body, restless disposition, dislike to tobacco smoking. From 12 to 1 p.m., head constantly confused j dull pain in occiput, which becomes severely burning on™ lying down, and while lying on the back goes gradually between tha| eyebrows. Every time he rises up a stitch in the forehead, whereupon the pain goes again towards the occiput. Heat and burning of eyes less, no appetite for dinner, a good deal of thirst. Afternoon, pain in head declining, heat in eyes gone, prostration of the whole body, but general feeling better. Cheerful humour. E., well.^ — 2nd d., 8 a.m., same dose as yesterday. From 9 to 10* a.m., transient stitches in the r. hypochondrium in rapid succession, two or four at a time, and occurring after xo m. Fulness of stomach, a flat feeling in it \ i^

seemed to be immediately below the gullet, inclination to vomit, and as though he should vomit on the slightest movement. Tension in abdomen. From lo to ii a.m., the stitches in hypochondrium less; head heavy, dull, a drawing pain just between the eyebrows j burning in eyes, which as well as the head feel hot to the touch 5 bitter taste, tongue dry; laziness and general prostration i ill humour. From 11 to 12 noon, head heavy, pretty severe pain along forehead and sagittal siJture ; head sways hither and thither as if intoxicated ; ringing in U ear, recurring three times in i h. ; a feeling like ants crawling along vertebral column j chilliness in hands i nails quite blue, pulse small and hard ; weariness of all the body ; drowsiness, frequent and violent yawning ; burning In eyes, especially when the eyes are shut and opened during yawning. From 1 2 to i p. m*, the dull pain in head has gone into occiput ; head always falling backwards, as though a weight were attached to occiput. Chilliness continues; hands quite blue, eyes always closing, weariness of body, ill -hum our, obtuseness of senses, constant yawning, no appetite. Afternoon : invincible sleepiness, followed by 6 h. of undisturbed sleep. On awaking, quite well. Slept afterwards 9 h. — 3rd d.,at 8 a.m., 10 drops tinct In Jh. violent inclination to vomit, great nausea, but no actual vomiring. From 9 to JO a.m., heaviness and bearing down in pelvis* Call to stool without result ; drawing pain towards navel and r. hypochondrium, from pelvis upwards. Slight chilliness along spinal column and upper extremities i occasional yawning; cessation of inclination to vomit* From 10 to II a.m., gradual advent of rigor ; face and hands quite blue, icy cold^ pulse very small, hard ; pain in abdomen gone ; head rather heavy, constant prickling along spinal column and in occiput. Very frequent spasmodic yawning, with violent gaping recurring two or three times per m., laziness of whole body, From 11 to 12 noon, rigor gradually subsided, yawning less frequent ; head dull, full, swaying hither and thither ; obtuseness of sight and hearing ; dejection bordering on melancholy ; he feels quite stupid ; eyes hot ; eyelids burning, drawing pain in centre of forehead, drowsiness. From 12 to i p.m., rigor quite gone, agreeable warmth ensues, hands and face warm, no longer blue, yawning less ; head full, the pain extending all over cranium, worse when touched, head swaying to and fro ; unconquerable depression, weariness, laziness, obtuseness of all senses ; the whole psychical sphere as tl paralysed, hence a kind of stupidity, brain feels constricted, he is unable to think of a subject for a few minutes. Disinclination [for all active exertion. No appetite; feet cold and staggering. He had to go to bed. Sleep soon came on and lasted 3 h. After waking, dull fulness in occiput, great weariness, tongue quire dry, little thirst, pulse small, often hard. Agreeable warmth all over the bc»dy. — The next three d. the drug was omitted, and the health was good. — 6th d., 8 a.m., 5 drops. Up to 1 1 a.m. no symptoms. From 1 1 to i p,m. ; dull undecided pain in centre of forehead, which goes off on pressing bath temples, but returns more severely after a little. Except weariness, no other derangement of health. In afternoon, ill- humour, dejection. — 7th d., at 8 a.m., 10 drops. Soon, inclination to vomit, then vomiring of mucus, A few glasses of water brought all in order, and the rest of

fS2

the d, quite well. 8th and 9th days, medicine omitted, lOth d., 8 a.fn^,

5 drops. No symptoms, {Ibid J)

ID. WEN2Et HooR, medical student, ^u 22» thin, almost phthisical habitus, sanguine-melancholic temperament, with predisposition to pulmonary ailments. At the commencement of the proving quite well with the exception of slight catarrh.

11th Nov,, 7.30 a.m,, 5 drops tinct. From 8.30 to g am frequent eructation with taste of apples, though he had eaten none. Catarrh worse inc., the cough very tiresome. — 12th, 7,30 a.m., 6 drops. Between 9 and tl a.m. eructation like yesterday, with slight nausea and inclination to vomit ; all day dull aching pain in frontal region ; stool noon and e, — unusual. Cough as before j restless sleep, — i3lh,

8 a.m., 7 drops. Urine turbid on passing, deposited tn \ h, copious^ white flocculent sediment, consisting of phosphate of magnesia; a glittering skin on the surface of the urine consisting of small elongated crystals. At n. copious perspiration ; catarrh declining, cough better. — 14th, 8 a.m. 8 drops. Urine like yesterday, catarrh as before. — 1 5th,

9 drops. Urine very red and clear, but after standing an hour quite turbid, and depositing a red flocculent sediment, — i6th and 17th. No medicine, no symptoms. — l8th, m., 10 drops. Afternoon, urine fiery red, after standing an hour a red pulverulent sediment. — tgtb, n drops. All forenoon frequent eructation with taste of apples ; inclination to vomit, dull frontal headache; noon, little appetite. Afternoon, urine milky, after an hour covered with a glittering skin and with copious white sediment. Two fluid stools. — 20th, 12 drops. Frequent eructation as before* Appetite good ; severe pressivc occipital headache j pulse 80. E., great weariness, and disposition to sleep. Urine clear, with glittering skin, — 21st, 15 drops. Frequent eructation. Great inclination to vomit ; headache, in forehead dull aching^ in occiput throbbing pain j appetite good, hut after eating again inclination to vomtt. Digestion bad ; at 10 p.m. still the taste of food in the eructations. 6 p.m. The occipital pain went off, but the frontal pain remained till he went to sleep. During a!i this time the catarrhal symptoms were only observed tn the forenoon. — ^2 2nd. Sleep restless. On awaking in morning dull headache, general malaise, pressure \t\ gastric region. At 7.30, 20 drops. The smell of the medicine disagreeable, causing him to shudder. Immediately feeling of considerable illness, pale face, salivation, trembling of limbs, and frequent retching, but not vomiting. Pulse weak and slow. Must go to bed, where he got better in an hour. Inclination to vomit almost gone, eructation frequent, then rumbling in bowels. 10 a.m., pretty well, could get up, but there was still weariness of limbs. After taking the medicine the headache went off, and did not recur. All the rest of the forenoon slight nausea with copious salivation. Appetite for dinner pretty good • urine very watery. — 23rd, no medicine. No symptoms. — 24th, The smell of the medicine was so disgusting to him that he could only take 5 drops in a pint of water. Soon eructation, rumbling in bowels, confusion of head, which lasted till 1 j a.m. and then suddenly ceased. Appetite for dinner good. Urine very turbid, cloudy. — 25th, 6 drops. Nothing observed except red turbid urine, which deposited a copious

»53

white flocculent sediment, apparently mixed with a red powder. Took lo drops on going to bed at 9 p.m.^ — 26th, Very restless n. On waking in morning dull headache and pressure in stomach. Took another 10 drops. Immediately watery vomit, with shudder through whole body* 111 feeling all forenoon. Pulse weak and slow ; appetite bad* Urme in forenoon watery, in afternoon milky with a thick glittering skin, no sediment. Nausea and confusion of head until e. — 27th and 28th, No medicine. — 2gth, The smell of the medicine, even greatly diluted, caused retching, so that he could not take any. — 30th, 10 drops on sugar. All forenoon frequent sour eructation, rumbling in bowels, slight headache. Two fluid stools ; urine red and turbid, without sediment. — ist Dec, m* 10 drops on sugar. 9 a.m. Violent frontal headache, with contraction of frontal and palpebral muscles. Nausea, ptyalism, inclination to yawn, pulse weak, appetite and digestion weak, frequent eructation with taste of food. Urine milky, turbid, with white flocculent sediment. Two stools j general weakness and prostration* — 2nd, 3rd, and 4lh. No medicine.^ — 4th, Digestive organs in order, appetite good, weakness gone, pulse normal, urine reddish with slight reddish sediment. — 5th, 10 drops on sugar* Forenoon, sour eructation, frequent yawning. Confusion of head* Urine turbid, red, no sediment*- — 6th, 10 drops. Eructation frequent, inch nation to yawn very great, dull frontal headache, ptyalism, pulse weak, appetite pretty good, digestion good. Afternoon, frequent eructation. Urine milky, turbid, with copious white flocculent sediment ; two fluid stools. — 7th, 10 drops on sugar. Slept ill j woke with headache and pressure in stomach. Soon great feeling of illness, frequent sour eructations, shuddering, frequent yawning, inclination to vomit, violent boring frontal pain, little appetite. After eating nausea and frequent vomiting. Urine, forenoon, clear as water ; afternoon, fiery red, no sediment ; two liquid stools, — 8th and 9th. On account of the anorexia and indigestion took no medicine. — 10th, 15 drops on sugar. Forenoon, sour c ructions, rumbling in bowels, increased saliva, confusion of head. Appetite pretty good, digestion bad ; pressure in stomach. Urine turbid, red, no sediment*^ — '^th, 12 drops. Great feeling of illness ; violent boring frontal pain, relieved by pressure, frequent sour eructation, weariness in limbs, increased saliva, appetite very bad, loathing of food, digestion very much disordered. Urine milky, turbid, vnth glittering skin and copious white flocculent sediment J two liquid stools j pulse weak and low. — I2th Sleep restless | m,, dull headache, frequent eructation with taste of yesterday's food* Little appetite. The symptoms gradually declined, and soon ceased completely, [Ibid.)

II. Dr. W. HuBER. a, 5th Sept,, m,, 10 drops 6x tinct, agar. After 2 h, giddy, confusion of head, like slight intoxication, lasting almost all day, with unusual weariness of the body. Good n. On waking it\ m, pressivc pain deep in r. frontal eminence, then painful pressive tension in tendons and ligaments of r. sacra! and lumbal regions, extending to glutseus maximus, only felt when lying on r. side, always going off on lying on 1. side. — 6ih, m,, 15 drops. About 4 p.m., giddy confusion of head, especially when reading aiid

»54^

Al W br

Mrri

looking at light, with weariness of hmh^ and general ehultrtioQ bliKjd i puUc much excited, strong, quickened, 77 ; the pulsation felt in almost all prts of body, eiiperUlly in epigastrium. N. On waking, m*, when lying on 1. side, a pressive tensive pain in facr lumbar vertebn**, extending thence to L hip, but went off at once lying on r. side. — 7th, 30 drops. At 2 pm, a violent stitch in elbow with simultaneous shock through arm as from an electric shock. —8th, 40 drops. During the d, a gnawing biting here and there on various parts of skin. — gth, 50 drops Severe coryxa with confusion of head ; white furred tongue, pappy taste, stitches in chin and elbows, with electric shocks in those parts, at same time frequent chilliness, and restless sleep. The coryza lasted itll 15th Sept. — t6th, m^ 15 drops of 5x dtl. Soon giddy confusion of head, scraping sensation in gullet, head confused all forenn. 9 a.m., digging pressive patn in 1. occipital and nuchal region, with weariness of lower limba, and great drowsiness* When lymg frequent muscular twitchings, now on the inner side of the L knee, now on the upper arm, now on the back at r. scapula* 8 p.m» 20 drops. In 2 h, smarting prickling for 25 seconds on 1. half of tongue ; afterwards smarting burning on a small spot of the dorsal spine that went off in a few m„ whereupon a similar sensa* tion occurred in the tip of the tongue. N, good. At 6 a.m., in bed, colicky griping in abdomen, extending from 1, ilium between navel and symphysis pubis through abdominal cavity to r. ilium, relieved by pressure, and lasting only a few m.^ — 17th, m., 30 drops. At noon confusion of head and slight cool horripilation on the scalp of crown with the feeling as if the skin there were stretched more tightly. After dinner unusually long and profound sleep. After sleep subsultus tcndinum on r. leg and r. foot, with jerking shocks there like electric shocks i afterwards smarting itching on 1. sole near toes and on index» N. good. On waking, m., some griping in bowels. — l8t 7 a.m., 40 drops, to a.m., head as if intoxicated ; weariness of legs in open air. 1 1 a.m,, burning stitch in 1. heel. Afternoon, transient shooting on crown of head. N. good, — 19th, 50 drops. Soon dry feeling of lips, buccal cavity and fauces for ^ h. After j i a.m., on a small long spot of r. glutaeus, a cooling sensation, lasting 20 seconds^ like the sensation experienced when quicksilver is taken into the hand. After dinner long sleep. E., 20 drops of 4X dil. In \ h. a slight ;ooling burning sensation in gullet and stomach. At 9.30 p.m. ^ in ed, the same quicksilver sensation again in r. gluticus, along with bruised pain in sacrum, frequent twitching and subsultus ot gJutsei, and a prickling running on anterior border of I. index, toes, and heeU his prickling was very like what one feels on frostbitten limbs in change of weather. After 4 h*, in the warm bed, a severe burning came in the feet as high as the ankles as though the blood in the vessels were hot, just like the sensation experienced in parts numbed by cold when exposed to sudden heat. This lasted J h., went off, and recurred. At night restless sleep, many unremembered dreams. In the m. on waking, while still in bed, a cutting shooting pain in inner canthi of eyes, with some mucous secretion there. Just before getting up a violent stitch from the spinal marrow in the sacro-lumbar region

»5S

towards the r glutapus. — 20th, 7 a.m. 40 drops. Soon a slight pressive sensation on crown of head, and on looking out at the window into the light and again withdrawing a sudden giddy stupefaction in head as though he would lose consciousness, with roaring in L ear* This lasted a few seconds, but a confusion of the head remained, which lasted all forenoon ; then there came on the r. lower jaw and surface of the back a short pain ; in the former as if fine, in the latter as if coarse splinters were pushed in between skin and flesh ; an itching, smarting, and burning, causing him to scratch now and again, in the skin, with transient stitches as from fine splinters in the point of the L elbow* After dinner, on a small spot of the K glutaeus muscle, the above cold quicksilver feeling. At 4 p.m., on lying down with the head resting on n arm, the body suddenly shuddered as with cold, the arm involuntarily drawn down to the trunk, and this was followed by several fine stitches on both elbows. N. quiet, — a 1st, m., 50 drops. Soon a short pain passing through the 1. side of forehead, dryness of buccal cavity, with scrapy feeling In fauces, fine stitches above L knee and anterior surface of thigh ; quivering of 1, upper eyelid ; subsultus lendinum on r. index and on posterior border of r. hand. At 2 p.m*, after dinner, smarting on posterior front of L border of tongue and under tongue on same side as from horse- radish. 3 p.m», the wellknown sensation on a spot of the r. natis and on the surface of the back under r. scapula. This cold feeling seemed to have its seat in the skin and muscular substance, and lasted several m* E,, 20 drops of jx dil. After \ h., in bed, an acrid bitter taste at root of tongue ; repeated griping iii L hypogastrium with rumbling in bowels ; heat of body as if sweat would break out, with roaring in I, ear, frequent muscular twitching in L calf, cramp-like pains now on the anterior aspect of thigh, above 1, knee, now in muscles of 1. leg, now In interior of 1, ear. At midnight woke and felt a stitch on a dorsal vertebra* Remainder of night undisturbed. M., on rising, bruised pain in r, hip, going off on walking* — 22nd, 10 a.m. 30 drops* Soon cramp-like pain for some seconds in region of spleen, followed by violent pricks as with coarse needles on the lower border of L orbit at the exit of the lower orbital nerve, with frequent muscular twitchiiigs on 1* temple. After dinner a hard stool, causing sore pain at anus* 6 p.m., tickling itching in K ear-lobe and external meatus, going off by boring in finger, cracking in both ears during empty swallowing ; e., in bed, twitching and serpentine subsultus in rectus abdominis muscle. N. quiet. — 23rd, 5 am,, 40 drops. After i h,, while still in bed, jerking convulsive shocks, first of r. leg, then of lower jaw, lastly of 1. arm, as from an electric shock, which appears to originate from the neighbouring joints of these organs ; thereafter frequent twitching of muscles of L temporal and zygomatic regions. Stitches in skin of r. calf and r, side of neck At 2 p.m., after dinner, another 50 drops. After { h. smarting stitches on tip of tongue, on point of chin, and on navel* At same time frequent subsultus tendinum in r. leg. — 24th. No medi. cine. After dinner, on a small spot of r* hough, the well-known cold quicksilver feeling with frequent muscular subsultus in various parts of body. 3 a.m*, woke and felt first internal uneasiness in all voluntary

muscles, followec! by trembling of whole body, especially lower jaw, lastly there came on a choreic muscular action, that could not be arrested by the strongest effort of will, there was twitching of the hairy scalp, temporal muscles and cheek muscles of both sides, on which there often occurred a pain as if splinters were pushed in betwixt skin and flesh ; the upper lip, lower lip, muscles of bcjth shoulders and back, those of upper and lower extremities, and especially the 1. deltoid muscle, the calf muscles, even the muscles of the soles, were similarly aflli^cted. The abdominal muscles were confusedly twitched. At same time jerking blows on several limbs, or violent shuddering of them, and frequent quick movements of single fingers. This lasted 2 h., during which the heart beat so violently that the sound of the heart's beats could be heard by the prover. The muscular twitchings were irregular, sometimes r., sometimes 1., sometimes simultaneous, sometimes in quick alternation* He then fell asleep, but woke at 7.30 with fine pricks in the border of the lower jaw. — 25th, 10 a.m., 15 drops, 2x dih 2 p.m., the above cold feeling occurred on the 1. natis and trochanter, 3 a.m., woke without cause ; after waking there occurred a pricking as from splinters on inner surface of 1. leg, close above ankle^ then, after a few minutes, a similar pain on same place of r, leg. Soon afterwards again a trembling uneasiness in all the voluntary muscle apparatus, followed by choreic involuntary muscular action in various parts of the body. Fell asleep at 5 a.m. — 26th, 10 a.m*, 30 drops. During the day, nothing but involuntary jerking of some muscles. 8 p.m* 40 drops on going to bed. The effects were : digging shooting pains in r, heel and toe as from splinters ; cramp- like pains on inner side of r. calf and 1, flank above hip, with frequent twitchings of muscles, especially on nates. N. good, M., after waking, while still in bed, the same thing occurs as last night, only in addition frequent electric shocks of single limbs and jerking up of single fingers. Shortly before getting up a digging pressive pain on 1. frontal eminence, with roaring in L ear. These went off after 3 — 4 m. — 27th, 15 drops, i, dil. After I h. a burning cooling feeling along oesophagus to stomach as after taking peppermint ; eroding itching, inviting scratching, in the hairy scalp of forehead, and in several parts of skin i at the same time a smarting sensation in Schneiderian membrane, with frequent violent sneezing and muscular jerking in 1, iliac region. After dinner transient pricking in tip of r. thumb as from fine splinters, and a short but violent pain on r. dorsal surface below scapula as from coarse penetrating splinters, with confusion of head and frequent twitching of upper abdominal muscles. After 9 p.m., in bed, a burning sensation of tip of tongue, as if it had been dipped in pepper, with a cramp-like pain in L side of abdomen above hip, lasting more than i h., relieved by discharge of flatus. Thereafter the above-mentioned cold quicksilver feeling on a spot about j in, long and some lines broad on the posterior aspect of r. thigh (in sciatic nerve ?), followed by a short cramp-like pain in r, calf and later also in L deltoid muscle. N. good. On waking at 4.30 a.m., a smarting sensation in tip of tongue as from pepper, followed hy a tickling itching spreading from the faucial orifice of r. Eustachian tube to interior of ear, lasting 8 to 10 seconds, and alter-

iS7

nating with loud ringing in K car* In addition^ every time he attem|)ted to swallow a creaking in both cars as from a wooden screw ; intermittent muscular subsultus at 1, scapula and 1. deltoid muscle^ with a violent convulsive shock of whole r. side of body proceeding from spinal column. — 28th» loa.m*^ 20 drops. After ^ h* muscular jerks in L forehead, lips, 1. scapula, 1. iliac region, r. knee, with itching^ like electric pricks, on hairy scalp and now and then on skin. Noon, transient digging pain in 1* occiput and K forehead. 6 p.ni,, fine penetrating very painfuJ pricking in middle of r. cheek, as if a splinter were stuck through the skin into the muscles, lasting 6 to 10 m» 7 p.m., 25 drops. At 10 p.m., in bed, the cold quicksilver fechng came in both nates simultaneously, and at same time itching pricking in crown of head, and regular muscular twitching in 1. forehead and temple. N. good. M., in bed, a short boring pain near r. os calcis in tendo Achillis, muscular twitching in both nates ; quick movements of single fingers and a horrible shuddering of whole body proceeding from a lower dorsal vertebra. ^ — 29th, 11 a.m. 40 drops. At 11.30 the well-known cold feeling in r. natis, not continuous, but at regular intervals, synchronous with each pulse, as though each time it were touched with an icy cold body ; soon afterwards violent pricking in L cheek where the infraorbital nerve joins the pes anserinus^ as if splinters were stuck in. After dinner, during the siesta, a Violent shock of the 1. arm, followed by undulating jerking of the upper abdominal muscles, and a scraping irritation in trachea, causing dry cough. At 5 p.m., on going from open air into a dark passage he was attacked by momentary nausea, with vertigo, as though he should lose consciousness. At 2 a.m. became wide awake, and immediately had frequent subsultus of muscles and tendons, with a violent convulsive shock of whole lower part of body, originating from an upper lumbar vertebra. He took no more of the drug after this, 30th, — A pricking pain as from splinters in the middle of upper lip, close to nose, and a similar pain in r. heel. — tst and 2nd Oct., m., in bed, frequent muscular twitching, especially in both pectoral muscles, in abdominal muscles, and in the pyramidal muscles at the pubic arch, accompanied by such a violent shock of the head, proceeding from the atlas joint, that he bit his tongue involuntarily.— From 2nd to 5th the same symptoms. ^ — In the n. between loth and nth he woke with unusually frequent muscular movements, during which the external muscles of the larynx were engaged, at same time there came between the dorsal and lumbar vertebra; a pricking pain as from splinters ; this was followed by the well-known cold feeling in the same spot, as if the spinal cord were touched there with a very cold body j some m. later the same pricking sensation in the cervical vertebra. — 12th., m., in bed, the well-known cold feeling in the r, axilU and 1. inner ankle. — From 13th to 15th similar symptoms. — iSth. An icy cold feeling close to coccyx repeatedly* ^I9th. Frequent, as it were electric, pricks in the skin, with shocks in several limbs and frequent muscular jerkin gs. — From 20th to 21st. Familiar symptoms. — 22nd, forenoon, while walking in open air a violent shoot like lightning through the cerebrum, with feeling as though he would lo&e consciousnesa. Noon, a pricking pain in i.

IS8

Sole, as from splinters* Afternoon, several jerking beats of the heart — cenvuhio iordii, E*, in bed, pressivc tensive pain in occipito-nuchal region at both sides of the atlas, with electric pricks in akin on anterior respect of r. thigh. Hardly had he fallen asleep when he was awoke by fa horrible shock in the interior of chest and throat with a piercing cry* This explosion seemed to begin in the diaphragm, and took its course in the back of the thoracic cavity, upwards along the oesophagus ur trachea (ncrvus vagus?), impinged with great force on the larynx, causing the above noise* The noise itself was a prolonged one, an^l not interrupted, as e,g. in hiccup^ About { h. after this there came on restlessness, a trembling shake, and lastly a positive convulsive condition of the lower jaw. This lasted but a few m,, but recurred several times in weaker degree. Later a slight pain in L molars, — ^23rd. During the day frequent electric pricks in 1. zygoma, and rc» peated muscular twitch ings, especially in L cheek »- — 2'4th, c., in bed ; in addition to several familiar symptoms pricking as from splinters in atlas-joint, crepitation in the lumbar and cervical vertebra?, and coldness of feet up to ankles. From this time the action of the drug was only in mere traces, ist Nov. — Recrudescence of the effects ; the noteworthy symptoms were — ^frequent clapping jerking in interior of r. tympanic cavity ; jerking of tensor tympani, with a sound such as is made by a metallic valve covered with leather, when it h set in motion.

b, 15th Nov, Began another series of provings with tincture prepared with fresh fungi. At 11 a.m. i drop in water. In 5 m. sudden vertigo, as though he would fall : it lasted only 5 seconds, and was , followed by electric pricks in r. knee. After dinner, before the siesta^ roaring in L ear, frequent muscular twitching in I. natis and a convulsive shock in I. shoulder. The sleep was unusually long and profound. After sleep a chilly feeling all over body, especially in both feet. 4 p.m^ smarting pricking in roots of cili^ of 1. upper eyelid. E,, prostration and weariness, 9 p.m., in bed, undulating muscular jerking \n 1. forearm, then in 1. thigh. After i h. heat spread gradually all over the body, until it became intense ; the lower extremities burned to such a degree that he must often throw the clothes off them. The blood seemed to flow quite hot through the vessels, the circulation was feverishly excited, the pulse strong, hard and quick, 1 1 p.m,, burning thirst. Accompanying these febrile symptoms were : cutting sore pain in upper part of 1. nostril, fek at every inspiration, but not during nasal expiration, at same time stuffed and coryza feeling, with discharge of watery fluid from both nostrils, frequent sneezing and yawning^ frequent slight hawking up of small masses of mucus from fauces and posterior nares, constant roaring in 1. ear with creaking in both ears during empty swallowing, acrid, smarting taste on 1. half of tongue, sore pain in tip of tongue, which seemed to be occupied by a vesicle* a not disagreeable burning cooling sensation from fauces through oesophagus to stomach as from peppermint or horse-radish, electric pricks in skin of anterior aspect of r. thigh, and violent convulsive shock of L shoulder. This febrile excitement lasted till midnight, after which the heat gradually subsided, and he slept and dreamt much th^t

J59

was not remembered » The urine passed at night was clear, sherrycoloured, and of normal quantity. Morning, a transient, rather severe, shooting deep in r. hypochondrium, coryza gone. — i6th. All foreneon, confused head, boiling roaring in L ear* Exhaustion of body, white furred tongue, slimy, sticky, taste. Afternoon pretty well. 6 p.m., a drops. Soon transient stupefaction of head. N. good. M. in bed, painful tension and pressure in J. hip and lumbar region, but only when lying on that side, going off when lying on r. side. Twitching jerking in hairy scalp above 1. car, close to concha, and sometimes in concha itself, muscular jerking on I. side of nape, L side of neck, 1. forearm, near joint of elbow, with violent electric shock of lower jaw coming up from a lumbar vertebra. — 17th, g a.m., 3 drops. Forenoon, stupef^c* tion of head. Afternoon, when inspiring air by 1, nostril a painful feeling high up, as if the mucous membrane were excoriated there, 6 pm. Ii) all 1. side of head, constant dull pain, which after 1 h. increased to violent digging, at same time roaring in 1. ear, rumbling in 1, side of abdominal cavity, flatulent distension of abdomen, slight griping between navel and r, hypochonder, discharge of much flatus smelling of tinct. of agar. ; prostration and weakness. In spite of the headache, fell asleep, but woke about midnight with violent digging pain in L temple, relieved by pressure of hand^ recurring when pressure was removed. After a while headache went ofF and he fell asleep. On waking at 5 a.m« itching in L meatus aud. ext., with a prick tn interior of ear as with an icy-cold needle ; pricking pains in dorsal vertebrsc, r. heel, toes of both feet, as from splinters stuck in ; muscular twitching close to 1. ear, 1, elbow, 1. intercostal muscles, both glutaei, and pcctoralis, with jerking shocks coming in impulses, now in K hip now in r, hand, proceeding from the corresponding joint. After getting up felt well all except bruised feeling in nape and occiput. — iBth, 8 a.m., 4 drops. Forenoon, confused head, smarting erosion on 1. side of hairy scalp, smarting pricks on border of r. upper eyelid, bruised feeling in r. occiput, great sensitiveness to cold, especially in hands and feet, with pale, ill-looking countenance. After dinner frequent twitching dapping or fluttering in tympanic cavity of r. ear Jerking of tensor tympani, and twitching in 1. abdominal muscles, and the wellknown pricking as from splinters pushed in, now 1. meatus aud. ext.. It cheek, r. upper lip, point of chin, now in dorsal vertebra, 1. pectoralis muscle near nipple, navel and various parts of skin ; at same time a pressive pain in r. side of fauces. Simylianeously or alternately with them sometimes there was frequent muscular jumping in ears, temple, face, uppci Jip, throat, chest, sacro- lumbar region, abdominal walls, extremities, with jerking movement of one or other thumb and single fingers. N* good* M., after waking, aching tensive pain in tendons of L upper arm, nQ;ir bend of elbow, lasting several m. — 19th, 8 a m., 10 drops. Noon, confusion of head, after dinner a short intimation of a dull digging pain in L temple, with the familiar cold feeling in r. natis, E., before going to bed, erosive itching in hairy scalp of occiput causing him to scratch, with frequent involuntary jerking of muscles of lower jaw. E., in bed, cramp-like pain in muscles of 1* upper arm below deltoid^ lasting some m.j thereafter a similar

i6o

pain from 05 II ti downwards towards the muscles of anterior aspect of r. thigh, with p^iinful twitching pricks in anterior of L car, at same time restlessness and considerable trembling of muscles of L upper arm and thigh, with slight jerky shocks of those limbs> and frequent muscular jumping in various parts. N. good. M.^ after waking, a sore shooting pain in inner canthus and beneath upper lid of r, eye, with a short cramp-like pain in the muscles of the anterior aspect of r. thigh^ and a pricking pain as from splinters stuck in r. heel and toes, — 20th, 8 a.m., 12 drops. Forenoon, transient prcssive pain in I. forehead with eroding smarting n^w and again in skin* After dinner restlessness in lower jaw and lips, with Hnc trembling movement and frequent twitching on and in r. concha, and twitching jerks in interior of r, ear. 8 p.m. A sudden lightning-like pricking in r. cheeky at exit of infraorbital nerve, close to orbital border, as from sharp splinters ; immediately afterwards a convulsive shock of the lower jaw, making him bite his tongue. N. good. M., after waking eroding prick in hairy scalp of I. parietal region, and transient pricking as from splinters in r. temporal region near eye, followed by muscular jumping in various parts. Both inner canthi sealed up with mucus. — 2 1st, 8 a.m.^ 15 drops. Soon a sore pricking pain in I. inner canthus. Forenoon, when walking in open air a digging pain from 1, forehead along parietal region through the whole cerebral hemisphere to the occiput, followed by pressive sensation in crown, with constant accumulation of water in mouth, causing him to spit frequently. After dinner, frequent twitching shooting deep in 1. side of cerebrum, and frequent pricks as from splinters stuck in, sometimes in r, pectoral muscle, in r. true and false ribs, sometimes in h index. E,, in bed, sudden violent pricking as from splinters in 1. cheek near eye, lasting some seconds ; thereafter similar pains in 1. side of back, beneath scapula, in 1. hypogastrium and r. toes, with frequent muscular jumping in various parts. N. good, M., in bed, pressive digging pain in r. half of occiput, with simultaneous splinter-pricks in middle of r. cheek and lowest ribs, with frequent twitching of various muscles. — Zind^ 9 a.m., 20 drops. Forenoon, bruised pain in L nape and shoulder, and transient pressive pain in tendons of 1. upper arm near bend ot elbow, lasting some m. Attcr dinner cold feeling in point of r. elbow, as if it had on it a piece of ice ^ at same time the familiar cold feeling in parts of both nates, and an icy coldness of both feet up to ankles, especially in big toes. All this in the room. 5 p.m. On raising L arm a violent dislocation pain In 1. deltoid, on attempting to raise arm felt as if thousands of splinters were in the muscle. This lasted 10 m. Afterwards splinter-pricks in r, intercostal muscles below nipple. N. good. As only well-known symptoms occurred the proving was stopped. — ^23rd, 9 a.m., a transient icy cold reeling was experienced in a small spot on the 1. side of thorax. — 24th, e, after lymg down a suden horrible pain as from thousands of splinters in the middle of the r. forearm, accompanied by a momentary feeling as if he would lose consciousness, when at rest. Thereafter prickings as with splinters for a few m. in r. cheek, just below the lower orbital border, that changed into a digging pain a$ if in the bone. — 25th, An icy cold

fcding above the proximal joint of the r. middle finger. — 26th. Splinter-pricks on back of r. hand near wrist, with frequent twitching of various muscles. — 27th. Frequent pricks as from splinters in dorsal and lumbar vertebrse, — 28th. Sensation in lumbar portion of spinal canal as though the cord or its membranes were touched there with a piece of ice, lasting 20 to 25 seconds. — 29th. Chirping, crepitatinjg and creaking in spina! column. ^ — 30th, At night, splinter-pricks in f, sublingual salivary gland, followed by great flow of saliva into mouth* Various symptoms of agaricus action were experienced by prover up to 1 rth Feb. of following year. They were sometimes mere traces^ at other times were as violent as ever. They were not only the wellknown symptoms, but several new phenomena occurred. Thus whco lying still in bed there was often a peculiar cracking znd creaking in the osseous parts of the nose, as though the spongy nasal bones were pressed or forced against one another. For many successive d. at the same h. in the m. in bed there occurred a constant chirping I deep in the occipito-nuchal region, as if a cricket were in the cervical portion of the spinal canal, lasting 4 to 10 m. One n. his whole household burst into his bedroom to inquire the meaning of a horrible scream he had emitted, but of which he was entirely unconscious. [Ihid.) 12. ViNCENZ KtETzrNSiCY, medical student, set. 21, robust, fullblooded, sanguine temperament. Healthy, except tendency to slight ^attacks of diarrhcea. — ist trial, 21st Oct., 7 a,m., 5 drops tinct. agar. in water, 9.30 a.m. Flying shoots in occiput, violent 1. semilateral headache. From 10.30 a.m. to 5 p.m., involuntary twitching of facial muscles on r. zygoma^ weakness of vision, heat and pressure inwards in eyes. From 2 to 5 p.m., confused tendency to fall backwards. — 22nd, 8 drops. At 8 a.m., slight painless vomiting smelling of alcohol. ^23rd. 10 drops. Drawing sensation in knees as in fever, from 1 1 a.m. to 7 p.m. ; the smoke of a cigar did not smell in 1. nostril, but very strongly in r. The hemicrania, twitching in facial muscles, weakness of sight, and tendency to fall backwards recurred. Frequent sneezing. Sleep profound, dreamless. — 2nd trial, i8th Jan., 7 am., 5 drops tinct. in water. 10.30, shootings across occiput, recurring every 10 m., sometimes more, sometimes less violent till 2 p.m. Complete ^anorexia. 3 p.m. till late in e., vertigo with tendency to fall backwards [From noon till 5 p.m. a painless feeling as from jumping of the tendons ■ of the r. upper arm ; similar twitching in r, zygoma. Late at n. [anxious palpitation of heart, with febrile thirst. Sleep restless. — ^I9tb, [Awoke in m. with bitter mouth, and drawing pain in knees. This ' and muscular twitching in face lasted all d. Noon, good appetite. In the e. the palpitation of the heart returned, but without the anxious feeling, N., sleep quiet. From 20th to 25th, no mcd ; no symptoms. —26th, 7 a.m., 10 drops. From 9.30 a.m. to I p.m., repeated shoots through the occiput, vertigo with tendency to fall backwards, sensation of jumping of tendons in upper arm, and twitching in n zygoma. No |appetite. Bitter taste lasting till 28th. Took a moderate meal without rappetite, and 4 h. afterwards had three liquid stools. 8.30 p.m., attack of violent palpitation of heart, with anxiety that caused sweat to break out, terminating in a restless half slumber, with dreams about

^ a usttav divamlvl il occy f red, o«rf of idbidi fe ««)fc£, tf 7 a.aL^ widi m fedb^ as ilier icvcf^ tUi>ct9, widi confiiied bead, b^cxer t»te, saorexa and pun kmm. He rcmamcd in bed is he §dit so ED, and to die coarse of d. jrcstcrdajr'i tfoipcoiBS iicancd» dioiigib less sevefdy, and tlie e; €MJkDnbmoa mm leisw Ad vodisttifbed drcamkas sleep restored him so fu tbac be couM leave hb bed next d. bj 10 a.Di^ but Tertigo and weakncii were ttin present* The scalding during nticcuitlioa lasted three dayt longer. {Itid,}

13« Franz Kr^us, medica] student, act. 23, sanguineous-cholcfic lempcrsiment, of robun frame, and, with the exception of an ague never seriously ill, — 30th Oct., m., took some drops of tinct. agar, in water. IJ a,m, flight transient heat in head, combined with mental fjiUi^uc as after long-continued intellectual labour, at same time slight pricki in I. upjicr eyelid, obtuse pains in eyeball similar to the pain cituned by pressing on the eyeball with the hand. Frequent call to urinate, the quantity of urine passed much greater than usual. This last lymntom lastecf all d,, as also the occasional recurrence of heat* —jilt, fcumc dmc. Same symptoms, with the exception of the eye piiitiA \ call to urinate again present, in addition, shooting pain in almost all rhc jointi, especially well marked in 1, knee joint and head-joint i the r. kjiecjuiiU was very painful i>n going upstairs, {Ibid,)

14* J. LANDHdMANN took tVom list to 27th July daily in the m.

^FVtlve globules moistened with the 300th dil, without result. From ^ESth July to 4th Aug., daily lo drops of the 3rd diJ. On the 29th ^Kj^ly and 2nd and 4th Aug. he had nocturnal emissions. From 5ih ^Hlu 8ih Aug. daily 30 drops of Ij diJ. without result. — 9th and 10th, ^■5 drops tinct. On m. of loth on waking, cough with loose cxpccto- ^BAtion. — ^iith» I2th, J 3th, 10 drops tinct. On afternoon of nth, sore ^Hbain on outer half of back of r, hand as though it had been slightly ^Burnt^ increased by touch. This symptom was also present on 12th, ^HL)n that day at noon, a sudden violent stitch in hepatic region. — 14th, ^■5 drops. — iSth, 20 drops. — i6ih, 25 drops. No symptoms. — 17th, ^MO drops. Forenoon, several times short dry cough. — i8th, 35 drops. ^^^ftcrnoon, unusual thirst. — 19th, 40 drops. Nocturnal emissions. ^Boch^ 45 drops, — 2 1st. No mcd. No symptoms. 22nd, 50 drops, ^Bl.y the chin studded with white, closely-set vesicles the size of a ^millet-seed, which go ofF the next d, when shaving. — 23rd, 60 drops, ^BKocturnal emission. — 24th, 70 drops. Nocturnal emission. — 25th, ^Bo drops. — 26th, 90 drops. — 27th, 100 drops, — 28th, no drops. No ^Bymptoms. — 29th, 120 drops. Many dreams at n., suffocative anxiety ^Bit dreams. Feeling aj if nose were quite stopped. An emission. — ^Botb, 130 drops. — 31st, 140 drops. — Sept. ist, 150 drops, — 2nd, Hi 80 drops. No effects. — 3rd, 300 drops. Forenoon, confusion of Bliead. 2 p.m. When lying noise in r. car, like the intermittent noise of a locomotive, going off" on rising up, recurring on lying down. E., on lying down, the same noise, it changed subsequently into the sound of a nail being knocked into a board at some distance. This lasted till he went to sleep, but both delusions of hearing occurred regularly by d. as well as by n. when lying, often alternating with one another, and lasting till 9th Sept,, but the last 3 d, the only sound heard was that of a nail being driven iJi, and it always became weaker. — 9ih. 7^he skin again studded with small

Ivesicles, which only went oft' after several d. — 20th. Similar vesicles Appeared near the r. corner of the mouth, and lasted till 24th. — 25th, pnc large and several small vesicles scattered over forehead, ^ — 27th. ^iolent coryza came on, probably the consequence of a chill ; the )N:iidity of the discharge caused an eruption about nose and upper lip. —30th. Repeated violent tearing in L thumb. After 17th Oct,, there appeared here and there on forehead small vesicles, and there was occasional tearing in the fingers. The urine during most of the time of the proving unusually lemon- coloured. (Ibid,) ^H 15. Dr. Lazar, set. 29, blond, sanguine temperament. Had an ^■nflammatory chest affection a year ago, since when suffers from ^Balpitation j otherwise healthy. — 14th Sept. An hour before break- ^Hast took 200 drops agar 2x, watery dilution. 8 a.m., dyspncea, as if ^Behest was too full, and after every deep breath — which he was obliged ^Bo take frequently — a squeezing and shooting pain in scrob. cordis. 10 a,m., above symptoms \n less degree ; a paralytic feeling in 1. hand id tension in r. forearm ; at same time stupefying headache and rtcltnation for mental work. Noon, less appetite than usual, pain In scrob. cordis gone, 2 p.m., very violent palpitation of heart, and Iways 5 m. after the commencement of the palpitation renewed and

5 P Qi-f licat to bee bp cspKciilljr tHe U 6 jwn*, luM md^ fell much better. palpitatioD. Slept <jf 2)1 the lim^

II ^in^ %ioknt

k, pain in r. temple

weariness in Jimbs aod

contiiities, at lame time

» dbe oiiddk Enger. 6 piio,,

' fatafacn, excc»$ivelj vtoleat

to iromt and mied sight

qnujuma with taste of lottai

L — m6A, Alter a good night's

^n tfce bodf. 6 ajB-, pdphatioQ for sevenl

mA ike rmrBtki of occMooal pressive and

puticnfaur* Fioai 2 p,ni-i

L sm di 6 pLfli. 6 p.m., attacks of

k » i^MiK. •cfci TSMMi^ pressure in brain like

bof beat oiichceb . . ^ in this severity tiU

S pMUt fhef Me quite gooe^ and only the m L arm fevML. f^cMihing of food, sourish, ii%* of bead,— 1 7th. Slept well All uhchc.^ ^ Nooo, no appetite, of ipirits, at same time dull F»Mi 4 fJOL tin c^ CDOstsnt pressure at heart, and emptj eructation. — i8th. 300 diiifs agar. 2,/ Felt nothing but cmpf pan in r. t&naMt^ geyeatly recurring and lasting some ou— i^dh, 5 pwoup noknt polpitaaoo and very fre«)uent diarrbcetc stoaU. — ^odu Towards e. and during tlie n. tmsjow and drawing pain in both legs and Icet. — aist. Macli eioptf esuctatioci almost all d., once like rotten esgs, no appetite. More tlian ten loose stook with griping and disc^rgie of much flatus. Daring iiis proving of agar, the scooU always continued diarrhccicy whidi was quiie contrary to bis usual siate«

Bruko Linxk^ M.D., set, 36, robust constitution, chdenc temperament. Health good^ but with a tendency to bronchia] catarrh^ and after a chill disposed to ^et colic and diarrhoea.

a. 1st proving : 14th July, m,, 10 drops tinct^, a second dos| at 10 a.m. Soon slight eructation, which, however, does not comi up, but stops in the lower part of the ccsophagus. After i h* scrapy burning in fauces, eructation of tasteless air. A feeling as if eructation would come like a pressing asunder of the orifice of the stomach, drawing tearing in K groin and anterior aspect of thigh down to its middle. Sore pain at lower angle of I, scapula as if excoriated. Tearing intermitting pain in r anterior thoracic wall. Drawing tearing intermittently at the outer side of 1, thigh, above knee to the hough, Comforuble menul state, with mild, accommodating, but serious

i6j

disposition, fine tearing on ulnar side of I, forearm. In bed at n,^ perspiration, especially on lower limbs^ with sensation of a cool air blowing on them* — 15th* No med. In K side of abdomen a pressive very disagreeable pain, causing inclination to vomit. E. in bed, sweat on inner side of lower extremities. On r, os ilii externally under glutsei rheumatic drawing pains, a pain in hip, drawing pressive head* ache in L parietal protuberance, affecting eye. Mental indolence. — 16th. No med, Tearing in L little finger down from proximal joint.

A, 2nd proving: 20th Sept., e., at bedtime, 12 drops tinct. agar. After being ^ h. in bed, a sudden, painless drawing in r* lower extremity, so that he raised himself up and looked around him. Shortly afterwards, painful twitches like electric shocks in r* etbow and wrist, — 2 1 St, noon, feeling of nausea, with anxiety in chest, quickened and [ audible respiration, mental depression j call to stool. This lasted till ihe midday meal, by which it was removed. 2 p,m., 15 drops. No noticeable effect. — ^24th, 25 drops, in afternoon. Sleepy very early. Easily irritated and put out of temper, E., tearing pain in posterior muscular parts of upper arm, lasting some time, then ceasing and succeeded by sore pain at insertion of J. deltoid muscle, alternating with fine tearing in 1. shoulder-joint posteriorly, which recurred several times, always more severely. Slept well. — 25th, 11 a.m., 25 drops of J St dil. An h. after dinner, fine tearing pain in 1. forearm intermittently recurring, running towards the hand as if betwixt radius and ulna, with a fixed pain on back of wrist, at same time a kind of numb feeling in skin of forearm, especially of back of hand. All afternoon, fine painless tearing, especially on radial aspect of 1. forearm. E,, cutting itching in rectum, just above anus, which compelled him to draw up the anus, but this did not relieve him j on the contrary, it was more relieved by voluntary pressing out ; it was like the feeling attending acrid diarrhoea, it lasted half an hour. Thereafter fine tearing in r. knee. Occasional anxious uneasy feeling in chest, as though he anticipated something extraordinary happening. Slept well. — 26th. After breakfast, painful pressure on a small spot in K temple. Traces of tearing in 1. upper maxillary region of face. Repeated tearing in K forearm, also in r. thigh above knee on outer side simultaneously with the facial pain. Slept well. — 27th, 100 drops ist dil. Almost all d, repeated attacks of fine tearing pain on 1. side of head, above and behind ear^ as if proceeding from a small painful spot, which however was not painful to touch. The same fine tearing in r. upper arm posteriorly sometimes accompanied by similar pain in I. forearm. The tearing is worst in 1. clavicle. No pam anywhere when touched. After dinner, profound sleep from which he awoke with painfulness and lameness of the limbs, which soon went off. E., tearing in L side of chest superficially, — 28th. In addition to the painful feelings of yesterday, there was a tearing pain with feeling of paralytic numbness in 1. leg. — 29th, c,, great weakness of limbs so that he staggered when walking ; great fatigue of legs when going upstairs. For a week after the proving he observed the above-described sensations, and on waking in morning heat of head and face, with a sensation of puffiness of the face, especially of cheeks.

M« HlMc< we MCK fiMK of e^ ^^MMH^ wkjcll it 4U is die

\mJlk$^U%^mh^mi

Took bj nistakc ip pfcviottd J cjniericp t be ovrtng to of riieiiiiisoc ^did^ nfirrraly wben _ by^ bffijglit [ if bragbchc of a dh in small spots of ibrefa bj^ tbe pain tn the eyelids. Aftel

noon, lumpy stool, preceded by moist feeling at anus, E., cutting in abdomen, also tearing pain in second joint of L index* On going to bed, feeling of disagreeable coolness in abdomen. Slept wclK — j ah. Painful cutting rn abdomen, as If colic were coming on, with urging to stool, and feeling as if diarrhoea were about to ensue. After discharge of flatus a firm stool, with scalding in urethra when urinating. 1 1 a.m., 40 drops. Satiety ensued before hunger was satisfied, and there was pressure in stomach. After cutting in abdomen a lumpy stool. Slight gone-asJeep feeling in extremities ; the hand went to sleep when writing. An itching place on the hairy scalp that had troubled him for months, and a patch of psoriasis at the boundary of the hair on forehead, disappeared during the proving, but a nasal catarrh that affected him every m, on rising was not altered. 5 p.m.j 50 drops. Immediately, sensation in rectum and anus as if diarrhoea were coming on^ but it did not. Burning in urethra on urinating, urine normal. Acute pain in splenic region. Soon afterwards soreness in tip of tongue increased by touch, lasting all e. Dislocation pain in 1, hip-joint for i h* Falling asleep of K hand while leading a child during a walk, E., pressing pain near r, nipple* At same time a superficial lightninglike shock in I. side of head. Throbbing pain in r. instep along dorsum of foot, — 1 2th, 9 a.m. J 45 drops, and after noon meal 70 drops. Till 3 p.m. very slight pressure in stomach. At 3 p.m., painful and hurried calls to stool, which was firm and passed with effort. Then tearing pain and tension between I. index and thumb, and in upper arm. Feeling of hurry and anxiety in chest, causing quick and deep breathing, as though he expected something extraordinary, with desire to sigh. Painful pressure in eyelids, especially r,, with great drowsiness. Recurrence of pain in spleen. Scrapy feeling in throat frequently. Sensation of electric twitchings in extremities. When walking painful pressure in r. side of chest near nipple, with relief by deep breathing. Later anxious oppression of chest. Paralytic feeling in 1. upper arm, nausea and confusion of head* — 1 3th, 80 drops Noon, pains in lower extremities, especially in r. hipjoint and outer side of r. leg, like fatigue pains, accompanied by tearing all afternoon and e., with feeling of unsteadiness and fatigue in legs. Dislocation pain in hip-joints. Also shooting pressive pains in chest and back, particularly below scapula? and on the corresponding anterior part of chest, necessitating deep breathing, which relieved A chap in middle of lower lip causing burning pain all afternoon and c, 9 p.m., painful tension transversely across lumbar region to sides of abdomen, where it was dislocation pain in abdominal muscles j produced bv stooping. Unsteadiness of legs, the knees doubled up under him. Giiawing, shooting pain on back, under scapulae. Slept well, felt stupefied on waking. — 14th, 8 a.m., tearing on outer side of r* leg above ankle-joint ; pricks as with many needles on 1, frontal protuberance* When sitting, pressive bruised pains in sacrum. Afternoon, great retraction of testicles towards inguinal ring. After moderate supper, very tiresome fulness and distension of belly, with oppression of chest, — ^I5th. Restless sleep with much tossing about, early waking with quickened respiration and catarrhal symptoms and oppression of chest. Chap in lip still painfuh The chief symptoms were the pains in the

lower extremities, especially hip*joint» md the chest and back pains.^ 1 6th. Extremely vioieni pain in lower cxtrcnaities, especially In L hip under glyt;t:i muscles^ unaffected by touch, pressure, or walking, aggravated by stooping low and changing the posttian of the affected p;*rts. Very acute, shooting, fearing pains on small spots of chomx anteriorly and posteriorly, t,g, on L side, at the uppermost false rib, under the scapul^i &c., unaffected by breathing. Pains in both sides of sacrum in c., rendering walking uncomfortable, at same time tearing pain in f.ear. — 17th. Slight manifestations of the hip pain j all day long a feeling in the head as if a violent headache would come on. The pain went off on directing attention to it, but returned when he was not thinking of \i. — i8th. Still uncomfortable feeling in sacral and lumbar regions. When walking, suddenly a painful contractive spasmodic pain in r, calf as if something there were drawn together, worst when raising up and setting down the foot, causing the kjiec to bend beneath him and making him lame. A dislocation patn \n neck, worst when turning towards 1., so that the head remained stuck in that position, and could not be turned back. The proving was now left off, but the medicinal symptoms continued to molest him for weeks.

d, 4th proving : 1st Dec, m,, 6 grs. of a trituration of equal parts of kkgar, and milk sugar* In l^ h. nausea and accelerated respiration, folrlowcd by feeling of uneasiness in belly, with sensation in anus as %f diarrhcea were about to ensue. Noon, 15 grs. After dinner, great heat and redness of face, unusual symptoms, 6 p.m* Sudden call to stool^ which soon goes off Great salivary secretion. When walking, such ^eakness of knees that they bent beneath him, at same lime fcchng of general illness, nausea, sad disposition. — 2nd. No stool yesterday — ^most unusual ; slept well, coughing up of clear lumps of mucus. M., 5 grs. Hard stool passed with effort in the c, 15 grs. at bedtime. — 3rd- No mcd. No symptoms. — 4th, m., 20 grs, Slight, transient, tearing drawing in r. knee-joint. Noon, violent, longcontinued prick like a needle continually pressed in at one spot just above the 1. eyebrow. The pain was removed by violent scratching. At same time, but lasting longer, fine-tearing pain in 1. elbow-joint, changing into pricking itching^ relieved by scratching. Drawing pains spreading from the interstice between L thumb and index to these fingers. Dull pain in 1. temple, and at the same time tearing pain in 1. lower costal region anteriorly. Acute drawing tearing in posterior side of 1. forearm, and at same umc above elbow-joint in upper arm. All these sensations translcntp Repeated itching pricking pain above r, eyebrow, going off by scatching* Needle-pricks at L side of forehead. Burning heat and redness of face. Tearing sh*ght pain on r. side of top of head. Painfulness of 1. eyeball. Pain in 1. lower costal region. Painful tearing in r. kneejoint. Much itching here and there on hairy scalp. Urinary secretion diminished. Itching pricking above I. eyebrow and 1. car^ on head, and various other parts. Quivering of l. lower eyelid. — 5th. No med. From early m., intimations of the hip and sacral pain, — the latter on L side, resembling lumbago. Itching in various parts, needle-pricks here and there. Much yawning without weariness, e, — 6th, m,, 30 grs, after breakfast. Very acute, sudden, pressive tearing pain in r.

i6g

eyeball, not affecting sight. Painful pressure on 1. eyeball, superiorly and externally. Violent paralytic, transient dislocation pain in tendons of dorsal side of L wrist, as from mechanical injury. Acute pressive pain in small spot in L temple. Sore pain in centreofl. thorax as after a blow, not affecting breathing. Pressive pain in r, eyeball superiorly and externally, momentary, but frequently recurring. Afternoon, the pain in chest became very violent, and a similar pain came \n r. side affecting the breath i it went off suddenly after lasting 2^ h,, and then there came on the pain above 1. eyebrow, which quickly went off, and was followed by discomfort in upper part of abdomen with feeling of nausea there and trembling of knees, which soon went off. E., great itching under L eyelid, as if in eyeball. During the whole proving! frequent discharge of inodorous flatus after distended feeling in rectum* Forcible expiration without cough brought away a great quantity of transparent lumps of mucus, with great relief to chest. — 7th. The dull hip pain in the region of the 1. os ilii very violent, lasted all afternoon, very tiresome when sitting, but going off completely when walking. Much flatus discharged, preceded by colicky pain, A soft, very copious stool* — 8th. The pain in L hip felt in the m, A great quantity of the gelatinous or starch-like expectoration for several d. past.^ — 9th, Still traces of the hip pain. Pain in r. side of chest, tearing on posterior aspect of forearm, {Ibid,)

Samuel Max, medical student, a;t. 20, strong constitution, sanguine temperament, in good health. 21st Oct., m., 5 drops tinct. agar, in water. In a few m., heaviness in feet and head, very transient. — 22nd, 10 drops, some confusion of head, heaviness and coldness of extremities, quivering of L upper eyelid, repeated at noon. — 23rd, 15 drops, confusion of head and quivering of upper eyelid* — ^Jist, 5 drops* Soon confusion of head and coldness of lower extremities. All right after breakfast, — 4th Nov., 10 drops. In 10 m., coldness of lower extremities. Heaviness of head and inclination to vomit, with watery erucutions. — 9th, 10 drops. Soon coldness m lower limbs and inclination to vomit. Transient headache. [Ibid,)
Dr. Ros£NB£RG, sct. 38, sanguinc choleric temperament, robust constitution, and, though corpulent, irritable* Disposition to lumbago, soreihroat, and fever. At present quite well. — 1st March, 7 am,, 10 drops tinct. Immediately, burning and scraping \n throat, extending deep down into 1. side of chest 9 a»m., these symptoms went off, and he took his breakfast, 1,30 p.m., when walking in open air, suddenly such a violent pain in the sacrum that he could not take another step ; at same time vertiginous nausea, the knees shook, he had to drive home in a cab. Here he vomited his breakfast, which removed the nausea, but the pain in the sacrum not only continued as violent, but extended the whole length of the spine to the nape. The spine was painful to the touch in several spots, E., alternation of chill and heat, restless sleep at n., many unconnected dreams, next m, quite prostrated and weak. — 2nd. Pain in sacrum and back still violent, so that he could not leave his bed \ frequent palpitation of heart, little appetite, no stool, copious secretion of urine of pale yellow colour, E., «ome chiliiness followed by heat. Sleep much disturbed. — 3rd. Sacral

pain better, dorsal pain still very violent on the slightest movement, £.^ pain in splenic region, rumbling in bowels, followed by a stool with effort. N,, better, no fever. — 4th to 7th* Went about his work, but any considerable movement cansed violent pain in some spots of the spine. Spirits very depressed, Appetite bad, stool irregular, animal food caused heartburn ; at n. he was troubled by flatulence and a deep contractive pain in splenic region. — 19th, 5.30 a.m., 5 drops tinct. He lay in bed 1 li h, reading, but could not pay attention to what he read ; he became irritable, was cross with his servant, and disposed to scold, A meeting he attended later excited him still more ; he got such violent palpiu* tion he had to go and lie down. He soon fell asleep, dreamt much, and on waking was bathed in sweat, and trembled. Later excessive hunger, but his food was not relished ; this irritated him ; he again got palpitation and convulsive cough with anxious sweat, and was so low* spirited that he could not bring himself to speak to anyone, and locked . himself up in his room. E,, qgict, ate a little and enjoyed reading' the newspaper. Midnight, awakened by a spasmodic pain in K side of abdomen, with call to stool, but on making an effort to evacuate there came a violent pain in sacrum that extended down into lower extremities. The lower limbs felt bruised and semi -paralysed. The call ta stool combined with a sort of tenesmus lasted till m., when violent shooting, burning pains low down in the spine came on. — 70th, The dorsal and sacral pain lasted all d. so violently that he had to keep his bed, and '\c quite still. E., the sacral pains were nearly gone, but the lower extremities were very painful, as though they had been bruised by a heavy weight. — aist to 23rd. So much better that he could walk out, though not free from pain j the lower extremities were most painful when he got up after sitting some time. — and April, 10,30 p.m., 12 drops of ix dil. Soon fell asleep, but woke at 3 a.m. with pressive headache ; yawned much, and every time he did so had an involuntary fit of laughter. These symptoms lasted about an hour and were followed by profound sleep, from which he woke at 6 a.m., and had convulsive cough, trembling of heart and anxiety* Next m. could go out, but his spirits were very bad. During the d., frequent yawning, E., drawing in back and sacrum. N., three watery stools, with pain in spleen. — 3rd and 4th. The same symptoms, though slighter. The dorsal and sacral pain lasted a fortnight lotiger. [Ibid,)

Rudolf Schmidt, medical student, began to prove on 15th Oct., with 6 drops tinct., increased the dose gradually till 28th, when he took 45 drops, but experienced no effects. — 29tb, 50 drops. In 6 h, a tiresome feeling of tension externally in the region of the thyroid gland, increased in e, 10 p.m., a similar tensive sensation in r. groin, increased by rotating outwards and extending r, thigh. This sensation continued on 30th, but went off on walking, returning when standing, and also slightly when sitting or lying. It increased towards e, amounting then to slight pain, the tension in thyroid remained always the same. — 31st. Pain in groin less when walking, worse when sitting, lying or standing. Increased in e. — ist Nov. The tension lasted all d., and interfered with walking ; he could only walk slowly. — 2nd to 4th. The pain as before in the groin j it is aggravated by touch.—

5th* Pa!n much relieved, not felt when walking, and the tension only Mi when standing, sitting, or lying. Tension in thyroid gland gone by the 8th. — 9th, 50 drops* After 8 h. the tension in groin returned under same conditions as before. It lasted till nth, returned for instants on 13th j by 15th was quite gone, {Ibid.)

Gottlieb Scholz, ast. 23, farmer, phlegmatic temperament, always healthy, bad complexion, tendency to pimply eruption on face, especially forehead, — 31st July, e., 3 drops tinct. Immediately qualmishness, nearly causing vomiting ; unusual drowsiness, — ist Aug., forenoon, 10 drops. Burning in interior of chest and a kind of Oppression. Fine pricking pressure first above eyes» Now and then shooting in I., seldom in r. temple ; pain above knee, on outer aspect of femur, as if bruised. Dislocation pain in t. ankle.^ — ^and, m., formication in scrob, cordis, with nausea. Dislocation pain in , ankle more severe. On and betwrxt eyebrows small, itching pustules, painful to touch, which disappear in a few d. Slight pain in eyeball when moved. — 3rd, m., 10 drops. Great repugnance and nausea, from the taste of the medicine. Fermentation in abdomen in J h. Nausea nearly increasing to vomiting. Burning feeling in scrob. cordis. Boring drawing pain in r. side of chest from without inwards, and a

I peculiar oppression lasting 5 m* Constant inclination to vomit all d. Symptoms all worse m. fasting and after food. Frequent pricks just above eyes. Cross humour. — 4th to 6th. Nausea and empty feeling in stomach, worst m. Stool soft. Every d. before eating in the m,, flat, insipid taste in mouth. Tongue furred, dirty yellow. Appetite diminished. — 7th, m., 10 drops. Soon, empty feeling in scrobiculus cordis. Immediately fermentation in abdomen. Sneezing caused by nausea. Feeling as if a stone lay in stomach. Pressive pain above I. eye. Frequent discharge of flatus. Burning and pressure on eyeballs, especially when moving them. Constant sensation in stomach as \f it sank like a great weight into the abdomen. Taste flat. Appetite going. — 8th, Pressure in scrobiculus cordis. Griping pinching pain in umbilical region. Drawing cutting pain in a hollow molar, during which the abdominal pains go off, but return when toothache ceases, — gth. Dislocation pain in 1. shoulder-joint. — 13th, forenoon, 15 drops. Pricks in rapid succession in first joint of L index. The following symptoms occurred cv^iy d. : — Crawling in scrobiculus cordis with nausea ; fermentation in abdomen ; inclination to vomit j empty feeling in stomach j sneezing during nausea ; griping pinching pain about navel j pressure and burning in orbits. — 14th. Griping pinching about navel. Constant nausea felt in chest. Satiety with empty feeling in stomach. Accumulation of flatulence, which causes oppression. {Ibid.)

Dr. Alex. Wagner, — a, 19th Aug,, c, 10 drops of 2x dil.in water. Next m. when going out felt slight griping in umbilical region for a short time. — 20th, 22nd, and 23rd, 15, 20, 30 drops. No symptoms, — 24th, 40 drops. Forenoon, confusion of head, weakness, occasional flying stitches in upper part of 1. chest. Weak feeling and drawing dislocation pain in r. knee, transient ; later colicky pains in belly, especially in umbilical region, lasting longer. For some d.

rya

afterwards occasionaJ griping and transient rumbling, with tendency to diarrhoric stods,

if, loth Nov, II p.m., lO drops i, dil. Next m. head confused, tongue thickly furred, taste flat. Later, pressive pain in temple. Forenoon, while walking in open air repeated transient griping and burning pressive pain in hypogastrium.^ — ilth, lo p.m., 20 drops. A dull pressive pain in r. hypochondrium towards the back, in the forenoon and for some h. afterwards. ^ — I2th, c.» 40 drops. Next m. furred tongue, bad appetite ^ after dinner full feeling and pressure in stomach, with much flatulence. — 13th, m,, tongue much furred^ flat, pappy taste, confusion of head, exhausted feeling when walking. In r. hypochondrium, more towards the back, pressive sensation with occasional shooting, especially when bending body to I., lasting all A Appetite diminished, with full feeling, as from flatulence, after food. Cross humour, with disinclination for work. At n. itching in navel and inner side of thigh,- — J4th, m,, furrred tongue, flat taste, anorexia, occasional pressive pain in hepatic region, itching on various parts of body, frequently changing its place, and making him scratch. — 15th. Furred tongue, anorexia, slight yellowish tinge of complexion, especially about als nasi and corners of mouth. Occasional yellow spots before eyes on looking at bright objects i tobacco not relished, — i6th. The same symptoms continue in slighter degree ; occasional shooting pressive pain in r. hypochondrium, increased by pressure. At n* more intense and long-continued itching in navel, pudendum, and inner aspect of thigh, making him scratch. E., 60 drops. — 17th, m., itching and burning at anus, as in tenesmus. Dryness and burning pimples on upper and lower lip^ which in the course of the day change into vesicles filled with yellow serum. On hypogastrium, navel, pudendum, and inner side of thigh an eruption appears, consisting of whitish papules, which itch continually, compelling him to scratch, whereby the burning and itching are only increased. The papules seated at the roots of the hairs bleed readily when scratched and leave behind reddish pimples. The itching began with feeling of creeping under the skin which described small circular lines, and was occasionally combined with pricks as with needles and burning. During the d. he felt on both iliac regions and on L arm a transient itching under the skin, II p.m., 80 drops. Slept uneasily on account of the excessive itching compelling him to scratch, not only in the former places, but also alternately on the arms and hairy scalp, which declined towards m., but only ceased at intervals* — 1 8th, m., tongue thickly furred, flat, rather sweetish metallic taste. Lips much swollen in consequence of the vesicles, which have become ulcers. Nape rather stiff'and painful on moving head sideways, especially to the r. L. side of head painful to touch through its whole extent. Tension spreading towards occiput and there becoming dull pressive pain with heavy feeling all d. The itching eruption spreads further in the abdominal and femoral regions. By d., great itching in 1. hough, and on anterior surface of r, knee, when walking ; also in sacral region. This lasts all d,, coming alternately in various parts of the body, and frequently changing its seat. II p.m*, 100 drops, — 19th. The itching and burning great at n..

disturbinjE sleep. It also occurred often during the d. on different parts. Forenoon, whilst walking,, violent contraction of flexor muscles of l. thigh, for l h, — zoth. The same symptoms — scratching all n, till blood came. — 21st. Itching somewhat abated. — amd, 11 p.m«, 150 drops.^ — 23rd. Very restless n., frequent waking on account of itching, especially about navel, pudendum, perinicum, and hairy scalp. M,, tongue covered with viscid mucus. Itching not quite so bad by d. — 25th. Another very restless n*, with frequent waking on account of the burning itching pain, which was almost incessant on the parts mentioned, and on others. During the d. burning pain was Icit on the parts which had itched all n., especially on the inner side of the thigh when walking. During the d. there was frequent but tran* tient itching on face, nose, cars, and hairy scalp, with great feelmg of exhaustion. The itching and burning lasted during a journey that occupied him till the xst Dec, as also did the readily bleeding eruption on navel, perinacum, and thighs. The n. of 2nd Dec, which was passed in bed, was nearly sleepless owing to the pricking and burning itching, especially on belly, thighs, and feet. — 3rd, mi, great exhaustion, compression of head, pressive pain in r. forehead, — 4th. Itching and burning, especially about navel and inner side of thighs, continued. It generally began in the c., increased in intensity till midnight, T'he eruption was seated at the roots of the hairs, each papule being pierced by a hair, and when it had continued for a considerable time 2 to 10 proliferations of the epidermis about the size of pins' heads were observed surrounding the hair like a rosary, and were with difficulty detached from it, (It corresponded to Hebra's lichen pilaris urticatus.) Constant dryness of upper lip, with tendency to chap and vesicular eruption on it. — 5*^ ^^^ ^^^- ^he itching and burning continued to such a degree that to get rid of it he tried various remedies. Washing with equal parts of spirits of camphor and water removed the itching and eruption in a short time. But he felt a good deal of the itching until 15th Dec, especially at night and particularly on the feet. — 1 6th. Occasional itching, especially on feet and perineum, at night, bnt no more eruption ; the nocturnal itching lasted till the middle of January, especially on the lower extremities, causing scratching till the blood came.

r. 22nd Jan., 10 p.m., 10 drops tinct. in water. — 23rd, m,, on waking, feeling of exhaustion and confused head. Tongue furred, white ; bitter taste. Pressure in r. hypochondrium upwards. After breakfast loose stool followed by griping in hypogastrium in forenoon while walking in open air. 10 p.m., 20 drops. — ^24th, m., tongue covered with thick fur; pappy taste. Later when walking in open air pressive pain in r. supra-orbital region for a short time. At 9 p.m., 30 drops. N,, very restless, late of falling asleep. Woke every h,, and difficulty of falling asleep, owing to tiresome smarting itching, specially about navel, pudendum, and pertnseum, sometimes also on inner side of 1. thigh and foot. — 2Sth, m*, head confused, tongue rurred, smarting in eyes. During d., frequent itching alternately on fiecl^ extremities, and belly j no eruption* — 26th, During d., pressive fivntal headache and occasional itching on belly. 9 p.m., 40 drops

— ^27 th, m., furred tongue, pppy taste, confusLcl IjiU. Forenoon and aficmoon, repcatcci attacks of griping^ cuitiM^ pains in hypogastrium, with flatulence. Frequent itching, causttig scratching about rSavcl. 9 p.m., 50 drops. Soon recurrence of culling pains in the bowels, with rumbling and rattling ; dryne$s of gullet, with istnngeni taste in mouth. Some transient acute piicks from fauces along Eustachian tube towards r. ear* — 28th, m., tongue thickly covered with viscid mucus j astringent metallic taste lasting all d., but in less degree* Discomfort in abdomen, with rumbling and occasional cutting griping* E*, itching about navel, causing scratching, with eruption of papules with red areola. 1 1 p*m., 60 drops. Soon the peculfar dryness of palate, especially felt when swallowing, with occasional stitches towards r. ear and r. parotid gland. Tensive drawing of both sterno-cleido-mastoidei, causing stiffness of neck. Griping and rumbling in bowels. — 29th. On awaking dryness of fauces and palate continues, spreading downwards to gullet, and contraction there ad though an astringent fluid had been drunk. T'ongue covered with viscid mucus. Taste flat, pappy, somewhat metallic. Feeling of emptiness of stomach alternating with pressure as from a heavy body there. In r. hypochondrium heavy feeling and drawing, as though the liver were increased in weight and dragged on its ligaments. Occasional sharp pricks as if radiating from the surface of the r. lobe of liver to its centre. Rumbling wandering about of flatulence in abdomen. Afternoon, several violent shootings in splenic region. 11 p.m., 80 drops. Some time afterwards the peculiar dryness of throat, with shooting towards parotid and submaxillary glands, tension in nape, flatulent movements in abdomen. Later, violent itching in abdomen and legs, making him scratch, with a scattered eruption of readily bleeding papules. — 30th, m,, tongue thrckly furred, dryness of fauces and palate, pressure on the liver, discomfort with frequent rumbling and griping in abdomen in forenoon and afternoon, it p.m., 100 drops. In I h. tensive drawing in r. jaw towards ear. Dryness in fauces, pressive and burning pain in stomach. Violent itching on abdomen in umbilical region and perinaeum, particularly severe on lower extremities, with eruption of papules. — 31st. Woke with furred tongue, pappy, flat, metallic taste, dryness of fauces and palate,-pressivc pain in stomach, with loathing and inclination to vomit. Feeling of exhaustion and confusion of head, increased by walking in open air ; occasional discomfort with rumbling and cutting pressive pain ia hypogastrium. Itching at n. in bed, especially about navel and inner side of thighs, but without eruption, lasted for another week, and then gradually went off. During the whole of February the tongue in the m. was covered with viscid mucus, its papilla were very prominent, and the peculiar dry and astringent sensation was perceived. The appetite also was decidedly smaller.

^. 27th February, lO p.m., 200 drops. Some time afterwards when reading feeling of fulness and confusion of head with drawing towards temples, increased feeling of warmth, especially on ears. Contractive dryness of throat, warmth and rough feeling in sternal region, —28th, m., tongue covered with thick viscid mucus, dryness and

astringent feeling m palate and throat i during the d* repeated rumbling and occasional griping in bowels, with several pappy stools. — ist March, Towards e. itching on lower extremities, especially 1., making him scratch* {f^id,)

Dr, Ferdinand Zeiner. a. 17th Junc^g a.m», 5 drops i, diL agar. Forenoon, empty eructation repeatedly, rancid taste lasting 3 h., pinching in umbilical region, cold feeling in belly, transient stitches alternating in r. and 1* frontal protuberance, aching in sacrum ; when reading the sight leaves him ; on going downstairs weak feeling in legs j this lasts while walking in open air ; it seems to proceed from the sacral region. The sun's heat causes violent vertigo. After dinner (at I p,m») could not get his usual siesta on account of violent burning pain in corn on r. little toe, and burning in 1. thigh. Slept well^ but next m. a small noise brought on violent shootings in r. frontal eminence. — i8th, 9 a*m., 10 drops. Eructation of air, scraping in throaty pinching about navel lasting till dinner. Soon after taking medicine frontal headache aching pain in sacrum with weakness of legs on walking in open air. Sneezing excited by the sun's light caused violent stitches in cscum j occasional violent stitches in anus ; shoots first in r. then in K knee. I h. before dinner bitter taste lasting i h,, but good appetite. After dinner the same burning pains in corn of r. little toe. Two pappy stools preceded by pinching in belly and accompanied by great discharge of flatus, £., fluent coryia, — iQth, 20 drops. Eructation of air ; nausea with anxiety, thereafter discharge of flatus. Slight pinching in belly for some h. ; three pappy stools ; when writing flickering before eyes, scraping feeling in throat with bitter taste ; coryza continues. E, sad in cheerful company, unable to take a part in conversation.— 20th. Coryza more severe. During d., while walking, smarting in thighs, compelling scratching, — From 21st to 26th. Frequent violent shootings in knees, weakness in feet, three liquid stools a d. at short intervals, frequent urination with increased discharge of urine. The coryza lasted till the 26th. On the 3rd d. it was very severe. First ft affected the I. side of the nose with the I. eye for 2 d, ^ then the r. side of nose and r. eye for 2 d. more j the discharge was acrid and burning. On the 24th, when the discharge diminished^ the nose swelled considerably, was bluish red and very painful to the touch i this terminated with desquamation of skin. My coryzas never used to end in this way, but with vesicular eruption on upper lip. — 25th, Felt an aching in r. eye as if a grain of sand had got in it under upper eyelid. Nothing was to be seen in the eye, only the secretion of tears was increased. Forenoon, depressed spirits, afternoon cheerful. On 1, side of scrotum the skin swelled, became red, and itched j in 2 d, the swelling was gone.

b, 2nd proving: 13th July, 5 drops 6th dil. Immediately* rancid taste, eructation of air, slight shooting in forehead, gradually becoming stronger, especially on 1. side. Weak feeling in 1. arm and ]. foot, uneasiness in the latter, compelling him to move it. In i h* eyes dim-sighted, the K outer canthus burned, and feeling of sand under r. eyelid. Head confused, full, could not go on with reading. In I h. pinching in 1. side of abdomen with discharge of flatus. Afternoon, frequent shooting pains in r. little toe, especially severe and continuous at 6 p.m., when sitting, relieved by waJking up and down

room. On rising from scat, twice shooiiiig on r, knee ; when walking at 7 p.m. a painful drawing in r. leg lasting 5 m.» on the anterior aspect of leg, extending over knee, with weak feeling in that leg* Slept well* M., on waking, headache, which soon went off* — 14th, 10 a,m*, 10 drops. Rancid taste, eructation of air immediately, lasting a long time j later, on trying to read the sight was dim, weak, a$ if through a veil, flickering before eyes; some shouts in forehead, cspccially 1. side. In f h. aching in sacrum, with weakness of legs when walking. Afternoon, shoots in anus. 6 p.m., when walking, violent shootings in both knees, for several m.,and continued aching in sacrum. Nose dry, and on blowing it some blood came. Appetite good, stool and urine normal. Slept well. — 15th. No med. Immediately on waking, depressed spirits, in i h. cheerful. When reading, eyes weak^ watery, dim-sighted, great exhaustion of whole body. £., a black, sanguineous blister in mouth, which discharged its contents next d. On front of 1. leg and on nates boils which were very painful. The boil on nates became as large as a hen's e^, was very painful and dis* charged, on the 7th d., a considerable quantity of black blood, no pus. This bleeding lasted 5 d. with occasional severe burning pain. Quivering of r. upper eyelid with feeling of weakness of it withcut having strained the eye ; the quivering went off gradually, but the weakness of the eyelid lasted 5 months. {Ibid,)

23* Professor D. J. von Zlatarovich. a, 8th June, m., 10 drops of a mixture of equal parts tinct. agar, and alcohol. After breakfast slight nausea, disgusting taste on root of tongue, dryness in fauces. — 9th, 10 drops; emptiness in stomach. After breakfast slight nausea, flatulent distension of abdomen, burning in r. leg. All forenoon uncomfortable feeling in abdomen, which is not distended, but feeling of flatulent distension in it. Noon, when smoking a cigar, exceedingly disagreeable taste, salty, bitter, especially at root of tongue; much saliva pours into mouth, slight rigor over back. Little appetite. After dinner, again the discomfort in abdomen, especially about navel, and the same disagreeable taste \ somttimes a very peculiar feeling of constriction under sternum. Afternoon, pretty well. E., the bad taste, the sensation under sternum, and the discomfort in abdomen returned. — loih, 5 drops. Noon, a disagreeable sensation in stomach with commencing nausea. Discharge of flatus. After breakfast severe burning under sternum for an hour. Forenoon, well. Noon, some tightness over chest, slight dyspnoea. Later, pressure under upper half of sternum. Till 19th took every m. 5 drops. — ilth, m., coughed several limes, severe pressure in 1. half of head. After breakfast^ burning along oesophagus, short broken sounds in bowels. Noon, very disagreeiible, sweetish metallic taste, slight pinching about navel, some tenderness under sternum, blowing of much mucus from nose. — I2th^ m,, cough. Soon slight nausea; afterwards transient stomach-ache^ and when this went off some pinching about navel. Forenoon, single attacks of pain under sternum. After dinner great distension of abdomen, several times dry cough, much mucus blown from nose,— 13th, m., coughing of mucus several times. About r. inner ankle painful burning of skin as in commencing erysipelas for 1 h. Slight

dii?comfort in stomach and bowels. Repeated sneezing, occasional tensive pain on chest, sometimes between shoulders, much mucus blown from nose. — 14th, m., some mucus coughed up, Noon^ slight burning in bowels. Pain In r, inner ankle returned* Forenoon, much mucus blown from nose, with burning in upper lip. — i5ih,m.,on waking, coughed up mucus several times, roughness in throat, slight burning in eyes, frequent sneering. Had also sneezed at n. without waking. Immediately feeling of pressure and coldness in stomach. Forenoon, pain in head externally, more in posterior half, tension In occiput towards ears, nape, and other parts. Sensitiveness of nasal mucous membrane. — i6th, m., cough repeatedly, with feeling of rawness in chest. Slight tenderness of eyes. Prcssive pain on crown, — 17th, m., coughing up of mucus. After breakfast, slight pmching about naveU discharge of flatus. The pinching became more severe, with call to stool. An insuiHcient firm stool. Forenoon, repeated slight

^ searching in bowels. A peculiar tensive pain in r. groin. Frequent sneezing, blowing of much mucus from nose, — ^i8th, m., severe cough with mucous expectoration, with raw feeling in chest. After break* fast, feeling of weight under navel. All d, repeated coughing up of masses of mucus. After dinner, transient tearing pains on shaft of K tibia, — 19th. Slept well, but awoke with violent cough ^ the first impulses of cough brought, along with a kind of convulsion of the

' whole body, thick expectoration, />, the cough came suddenly and was so violent that he must double himself together, draw up the legs, and even move the arms. The subsequent fits were not so severe, brought away no expectoration, and were accompanied by sore feeling on the chest. This all went oif after a short while. Some burning on the skin of r. leg. Blowing of much mucus from nose* — toih and 21st. No mcd, M,, several mucous coughs. All d. much mucus blown from nose, without further catarrhal symptoms. For several d, past there has been much itching in scalp towards nape, causing continual scratching, — 2Znd, 5 drops. M., several violent coughs with mucous expectoration. Much mucus blown from nose. 1 1 a.m., headache, especially weight and tension in occiput and towards nape. In r* upper arm some tension felt on movement. — 23rd, 5 drops. M., mucous cough. Ten., sion in upper arm continues. After the dose, disagreeable sweetish taste, which lasts some time after breakfast. Noon, slight stitches and tension on chest. Afternoon well, — ^2fth, 5 drops. M,^ mucous cough, tension in upper arm gone. Some weight in stomach and abdomen. Discharge of flatus, — 25th. No med. Much mucous cough. Burning in r, leg, slight pinching and rumbling in bowels, low spirits, — 26th, 5 drops. Slept well, but passed an unusual quantity of urine. M., mucous cough, occasional transient drawing pain in some long bones. After breakfast slight pinching in abdomen, discharge of flatus. In r. upper arm painful tension on movement. Copious pappy stool, followed by feeling of weight in hypogastrium. During the d, well except occasional cough. — 27th, 5 drops. Slept well. M,, great sexual excitement. Much mucous cough and nasal mucus ; pressure in stomach, weight on chest. Tension in r. leg. Forenoon, very tired after a moderate walk. Skin of whole body, especially face,

very smooth, soft, and free from pimples. — 28th aiid iQtb, each d.^ ^5 drops, M»» mucous cough, distension of abdomen, burning on r. leg. ^ •30th, 5 drops. M,, mucous cough. Coolness and weight in stomachs Snee^ted several times. Afternoon, on working hard, frequent cough, whirling running in scalp, occassional pressivc pains in shin-bone. — ist [uly, 5 drops. Slept well. M*^ roughness in throat and mucous cough, ome pain in r* leg. After dose disagreeable sweetish taste, weight in abdomen, Forenoon, well. Noon, disagreeable taste like the mcd» Discomfort in abdomen, and also in whole body. Feeling as if belly were quite empty, — 2nd, 5 drops. Slept well. M., mucous cough. After dose weight and discomfort in stomach, slight drawing atid pressive pain in r, shoulder. Forenoon, frequent drawing pains in 1. forearm bones, alternating with similar pain in shaft of r. tibia. ^ — 3rd, 5 drops. M., cough as usual. After dose, urging towards anus. Forenoon, frequent tearing in bones of J, forearm. Warm feeling in anus. — 4th, 5 drops. M., loose cough. Burning on r. leg, slight urging in hypogastrium, discharge of flatus, itching and small pimples on occiput, near nape, — 5th, 5 drops. In the n. and m., violent cough with mucous expectoration. After dose, pressure and burning in stomach. Forenoon, short tearing in bones of I. forearm. Noon, pressure in both temples. After dinner, burning in chest. Much cough, mostly dry, with mucous rales, but no expectoration. Afternoon and c,, little cough, but much nasal mucus. — 6th, 5 drops. M., loose cough and slight pain in r. hand and bones of fore* arm. During d,, frequent loose cough. — 7th, 10 drops. On waking, much mucous cough. After dose, slight burning in stomach. A vesicle on vermilion of upper lip, that burns. — 8th, 10 dro{»« M., loose cough. After rising, some pressive pin in r, side of chest. Much flatus discharged. Vesicle on upper lip gone. Nasty, bitter, resinous taste. Dryness in fauces. After dinner feeling of distension of abdomen. Peculiar, burning itching in r, wrist, as from a bristly hair. E., cough with thick mucous expectoration. — 9th, 10 drops. Difficult waking in m. After dose transient pinching psin in bowels. Discharge of flatus. — loth, 10 drops, M., mucous cough. Insufllcient stool, followed by distended feeling in belly.^ — i ith, 10 drops. M., much mucous cough* After rising, call to stool, but only a little hard evacuation ; later, an ordinary stool. For several d., occasional itching on occiput, where small pimples appear. — I2th, 10 drops. All d. well, except the usual cough. — 13th, 10 drops. M., mucous cough. Some itching and fiore places on hairy scalp. After dose, emptiness of stomach. Burning on r. leg. Some itching at anus. — 14th. Well, except usual cough. — 15th, Changed to pure tincture, of which he took 2 drops, in m. Mucous cough, slight pressure in stomach. Sometimes drawing pains in fingers, as if in periosteum. Sometimes internal pains on bones of legs. — 1 6th, 3 drops. M,, mucous cough. Soon heaviness in abdomen, |Cspecially about navel. This soon went off, but there came on a peculiar smell of the tincture. — 17th, 5 drops* M., coughing up of mucus. After breakfast, heaviness in abdomen, especially navel, discharge of flatus. On the heavy feeling sinking down in belly, urging to stool, which is firm and unsatisfactory. — ^iSth, m., loose cough. After d<^c, heavy feeling in stomach, discharge of flatus. After breakfast.

^79

the heavy feeling descends, lasts an hour, and goes off without stool.— 19th, 10 drops. AL, some mucous cough* After dose, weight about navel. Forenoon, frequent cough, dry, or with mucus, and pressive pain under scapula* Exhaustion and much affected by the air. Slight drawing about both ankles. — 20th, 15 drops, M., usual cough. Soon after dose, slight pinching here and there in belly, more in the integuments than bowels. Discharge of flatus. After breakfast, pressure in stomach and transient burning in hypogastrium. Forenoon, frequent short cough, rarely mucous expectoration. Noon, again some abdominal pain, sometimes in scalp at occiput tearing, tensive sensation.^ — 21st, 20 drops. Slept well, but often ground teeth in sleep, M,, some cough with mucous expectoration. After dose, disagreeable feeling \n stomach, rumbling in bowels, discharge of flatus. Forenoon, much mucous cough. Afternoon and e., frequent itching here and there in body* Burning on r. leg, — 22nd, 20 drops. The med. has a disagreeable taste. After breakfast, slight searching in hypogastrium with flatulent feeling, some mucous cough. — 23rd, 25 drops, M., some cough with mucous expectoration. Discharge of flatus* Sneezed several times. After breakfast, transient pressure and tension all over chest, ^ — 24th, 30 drops. Nothing but loose cough. — 25th, 30 drops. M., loose cough. Soon after dose, rumbling in bowels. Weight and bearingdown in hypogastrium. Burning on r. leg. — 26th, 30 drops. iVL, occasional coughing up of mucus. After breakfast, very disagreeable, sweetish sharp taste, weight in hypogastrium, slight urging to stool, lumpy stool, thereafter shght burning in anus. — 27 tb, 35 drops. On waking, frequent violent cough, slight drawing about both ankle-joints. Soon after dose, slight pinching in hypogastrium. After breakfast, copious loose stool, thereafter slight tenderness and flatulent feeling in hypogastrium. Bad taste. 11 a.m. A second semi-fluid stool. After dinner, great distension of abdomen. — 28th, 35 drops. M., some loose cough. Sore pain on anterior surface of chest, especially r. side, near sternum, as if under ribs. Soon afterwards, loose stool, when the pain in chest went off, but beneath navel, in a spot the size of the fist, a feeling of weight and kneading together, lasting i h. — 29th, 35 drops. M., mucous cough. Noon, painful drawing in occiput, which went off for a couple of h. at noon, but came back after dinner. For some d, the skin on the inner surface of the lips is apt to come off" when smoking cigars. — 30th, 40 drops. Some discharge of flatus and feeling of weight in hypogastrium. Disagreeable sweetish taste. Some loose cough, rumbling in hypogastrium. Forenoon, when sitting, a disagreeable drawing and tearing in shafts of long bones of upper and lower extremities, occasional tiresome dryness of mouth and fauces, which parts are sensitive to the air. — 31st, 40 drops. M., loose cough. Soon heaviness in hypogastrium, discharge of flatus, — 1st Aug., 40 drops. Soon, feeling of flatulent distension and pressure in hypogastrium. Cigar tastes bad. Coughing of mucus. E,, disagreeable sensation in fore part of urethra, along glans, making him press the part,^ — 2nd, 40 drops. M., coughing of mucus, flatulent distension in abdomen, transient lightness of chest. After dinner, short dry cough. — 3rd, 45 drops. Immediately slight transicjit burning pain in hypogastrium.

i8o

Some mucous cough ; discharge of flatus. — 4^h, 50 drops, M,, mucous cough. Epithelium on inside of upper lip detached in flakes. Two h. after dose, pressure and burning in stomach, lasting i h., then feeling of weight and distension in abdomen* This lasts a short time^ and is replaced by feeling of emptiness. — 5th, 50 drops. M., mucous cough. Discharge of flatus. Soon after dose, feeling of weight in hypogastrium. Forenoon, when walking, for 1 h* a kind of pointed pricking from within outwards on lower half of chest and abdominal integuments, — 6th and 7th^ 50 drops. Nothing but mucous cough, and discharge of flatus. — 8th, 50 drops. M., twice coughed up mucus. A hard, unsatisfactory stool. Noon, disagreeable sensation in anus like weight or fulness, goes off when sitting,^ — 9th, 60 drop. M., coughs up mucus. After rising, copious stool, soon afterwards transient feeling of weight in hypogastrium. Forenoon, when walking, great thirst. — luth, 60 drops. M,, coughs up mucus. On waking, I. semilateral headache, going off on rising. After dose, burning in stomach and weight in abdomen, burning on r, leg. E., on undressing, finds on back two tnfl.imed pimples, which on being pressed exude bloody pus — llth, 60 drops. M., coughs up mucus, copious loose stools, thereafter slight burning at anus. Occasional tension in scalp. After dinner, discharge of flatus* An inflamed pimple on r. check, — 12th, 60 drops. M., mucous cough. After dinner, short dry cough. — 13th, 65 drops. M., coughs up mucus ; all forenoon, copious sweat.— 14th, 70 drops, M., coughs up thick mucus, slight burning in stomach, weight in abdomen, loose stool followed by slight burning at anus. Forenoon, great thirst for beer. After dinner frequent, short, dry cough. — 15th, 70 drops. M., coughs up mucus. After dose, warm feeling in stomach, eructation of air j on back an inflamed pimple, which when pressed exudes much pus* On hairy scalp several spots covered with thin scabs. — i6th, 75 drops* M,, coughs up mucus. After dose, discharge of flatus, weight in hypogastrium, — 17th, 80 drops. Difficulty of waking. Coughs up mucus. After breakfast, weight in abdomen. Transient feeling of creeping and running through all nerves, proceeding from abdomen. Burning in skin of r. leg. Forenoon, when walking, very much fatigued, E., after drinking a glass of beer and smoking a cigar, became suddenly sick, must vomit up dinner undigested. Soon afterwards felt well, very hungry, ate and drank without further symptoms. ^i8th, 80 drops. Slept well, but perspired much at night. On waking, severe cough with expectoratiou of thick mucus. Soon after dose, weight and tension in hypogastrium. Occasional cough during d.^ 19th, 85 drops. Awoke frequently at n, by violent fits of coughing, Soon after dose, weight in hypogastrium ; flatus present, but not discharged. Urging towards anus.— 20th, 85 drops. Coughed much at n., perspired. Immediately after dose, weight under navel, urging of flatus, thereafter rumbling in bowels, whereupon the feeling of weight goes off, — 21st. Two such violent fits of coughing in the n., each of which lasted i h., that he took no med. The cough was provoked by tickling in trachea, was generally dry, but sometimes with mucous expectoration. After rising and during d. very little cough, but in the c. had several violent coughs. — aand, 85 drops. Having coughed but

little during the n., resumed the proving. Soon after dose, oppression of chest and slight coughing up of mucus, — zyd^ 90 drops. M., some loose cough, pres&ive pain in 1, forehead* Pressure on chest. Taste disagreeable, sweet, resinous. A small loose stool, followed by weight about navel. Forenoon, great thirst. — 24th, 95 drops. M.^ a little coughing of mucus. After dose, weight in abdomen, scanty, half-liquid stool, slight pressure on chest. Burning on r, leg. Forenoon, a second similar stooU After dinner, great burning on r. leg. Forenoon and afternoon, though had eaten well at noon, very nasty, sweet nauseous taste. Afternoon, frequent coughing of mucus, with feeling of weight on chest, — 25th, 100 drops. Immediately, weight and tension in abdomen* Aker breakfast, a scanty, loose stool. Thereafter feeling of flatulence in abdomen. This goes off after a while, and is replaced by the disagreeable taste. Burning in r. leg. — 26th, 100 drops. M,, coughing up of mucus. After breakfast, very disgusting taste, an insufficient, semi-fluid stool, burning in r. leg, distension in abdomcn« Well during d. E., great itching on back, where several small, red, slightly elevated points appear. The itching lasted J h. — 27th, too drops. M., hardly any cough. Some rumbling in bowels, discharge of flatus. After breakfast, tension over chest, as though it could not be sufficiently expanded. A copious loose stool, followed by flatulent feeling in abdomen, and then slight shooting from within outwards, through abdominal integuments, as though in peritoneum, which soon goes off. — 28th, 100 drops. M,, only coughed mucus twice. This cough, which he had throughout the proving, was peculiar. It comes on suddenly, is so violent that it cannot be suppressed easily ; several coughs follow one another, which cause him to cower together, and bring the tears to his eyes ; then the cough ceases for a considerable time, often half a day. After the dose, rumbling in bowels* A copious soft stool, followed by flatulent distension of abdomen. After i h, bruised feeling, pain of the whole anterior thoracic wall, with some oppression of breathing. Sweet, nauseous taste. During the d., occasional violent, jerky coughs. Sexual desire during the proving pretty strong. — 29th, 100 drops. M., mucous cough. Soon after dose, tightness all over the front of chest, lasting ^ h. During the d. several times fine pricks on various parts of skin, as with a needle, nothing to be seen. Forenoon, weight in abdomen under navel. Forenoon, some violent coughing fits with mucous expectoration, between whiles the chest is quite free. — 30th, too drops. M., coughs mucus. Soon after dose, warmth in abdomen, discharge of flatus. A couple of fine pricks through urethra. After h h, tightness over front of chest with some oppression of breath. A half-fluid stool. Sweetish nauseous taste. Pncks through urethra again. Later, many fits of violent cough. Forenoon, while dining, tensive pain in region of bladder. Little appetite for dinner. After dinner, very disagreeable taste. Occasional very violent cough with expectoration of mucus. Afternoon and e., almost no cough, chest quite free. When walking, shooting burning pain in ankle-joints in fits, also fine shooting in knee-joints. The bad taste frequently returns, especially after drinking beer, —31st, 100 drops. M,) a few coughs with mucus. Immediately after dose discharge of

l82

flatus. A consistent stool, afterwards feeling of flatulent distension in abdomen. — ist Sept*, lOO drops. M., a few slight coughs witK mucous expectoration. After dose, discharge of flatus. A fit of spasmodic cough ; after a little another* Then the chest becomes painful. After i h. drawing prcssive pain in legs, especially ankles. After a copious loose stool distension of abdomen. Disgusting taste. During forenoon, at intervals of 2 or 3 h,, fits of coughing. Drawing in forearm occasionally. Noon, creeping and burning in skin of both legs from hip to heel. — 2nd, lOO drops* M., viulent cough in fits, generally dry. i h. after breakfast, extremely disgusting sweetish resinous taste and flatulent distension of abdomen^ Forenoon, several convulsive fits of coughing. — 3rd, 100 drops. M., several coughs with mucous expectorationt The cough resembles whooping-cough, a deep whistling inspiration is followed by several short shrill-sounding coughs, with cowering together of the body, inclination to vomit, tears in eyes. The epithelium on inner surface of upper lip becomes again detached ; feeling of weight below navel. A loose, unsatisfactory stool, followed by the disgusting taste for | h. During d. several fits of coughing. — 4th. No med. Coughed frequently during n. M., very unwell. Prostration of body, confusion of head, burning of eycSy dryness of nose. After rising cough returned ; pressure and drawing pain in chest continues. After a little, severe drawing in loins and sacrum. Forenoon, febrile excitation, chiefly chilliness, occasional flushes of heat, severe headache^ especially in crown, now and then fit of violent cough i no thirst* After dinner, cool and sleepy. After slumbering for i h. got warm again, less headache, coughing fits rarer, feels rather exhausted. In a short time a violent rigor i he lay doubled up on the sofa, Teeth chattered, headache in crown severe, hands blue, no thirst. Went to bed, soon got warm, but headache lasted longer. Slept with interruptions at n., groaned much in sleep, and towards m. had copious sweat with relief. The spasmodic cough comes more frequently^ but he could suppress it. But when the cough did come it was so violent, shook him so much, that he had to sit up in bed, as the spasmodic contraction of his windpipe threatened to suffocate him, — 5th. No med. M., well, except exhaustion and sacral pain. On rising much flatus discharged. On sponging back felt a peculiar sensitiveness along spine that suggested to him spinal irritation j later, when stooping, a peculiar pain fulness along spine, especially dorsal vertebrae. (Perhaps the cough was also of spinal origin.) During forenoon, very sensitive to cool air. Eyeballs painful when touched, and moving them was diflicult j they felt tight in orbits. After dinner, slight pains in back and tightness over both sides of chest, from baclc to front. Later, this tightness was felt chiefly in lumbar vertebras, making bending forwards difficult. Flush of heat in face, with sweat on forehead, h., no fever, but had great general illness and discomfort. Drawing and stretching pain all along spinal column, and occasional transient pains along the course of the spinal nerves. Spinal column sensitive to touch. Drawing and stretching on anterior surface of thighs. — 6th, No med. Slept very ill -, the pains along spinal column were so

violent that he could find no easy position in bed ; the drawing and stretching pains in whole r. leg very severe. In the n, great heat,

flowing face, towards m. some sweat. At n. several fits of coughing. 'l,y the spinal column so sensitive that even leaning back in chair caused pain. On upper lip several painful, not red pimples. During forenoon, chilliness, constant disagreeable sensation all over back, especially in spinal column. The fibrous aponeurosis in r. thigh is painfully tense. After dinner, spine painful ; especially a space about the size of a palm on middle of spinal column is very sensitive to touch and to every movement of the body. Constant incitation to cough> but the cough can generally be suppressed, but when the cough comes it is very painful, and generally dry. E., backache slight, but r. thigh very painful. Almost no cough. Movement of eyes in their orbits slightly impeded. After supper, the back pains return. — 7th. No med. Woke up about midnight with such violent pains along back, over chest, loins, in r. thigh, that he could sleep no more. Tossed about in bed for an h., then got out of bed at i a.m. Took 2 drops of rhus tox. a. In i h. the pains abated, went to bed and slept till m., getting into profuse perspiration. M., exhausted, on rising slight backache, copious loose stool with discharge of much flatus. Fits of coughing rare. Noon, back pains pretty severe, presjjurc in ^yes. Afternoon, well except a few short fits of coughing. — 8th, No med. The effects of the agar, seem to be at an end. Almost no cough in the n. J only the slightest trace of pain in back and legs. During the d. coughed several times, and after every cough sneezed several times in succession. — 9th. Coughed a few times on waking, and expectorated mucus. Some spots on head painful to the touch. During the d. several violent but short fits of spasmodic cough. — loth, 100 drops. M., several violent coughs with little expectoration. A copious loose stool, thereafter a violent fit of coughing, with inclination to vomit and tears. Very disgusting taste lasting all day, and great tendency to spasmodic cough, especially when smoking. — i ith, 100 drops. In the n. such a violent fit of coughing that he had to sit up in bed, and for a long time could not get his breath. After breakfast, distension of abdomen, discharge of flatus. After every fit of coughing violent sneezing. — 12th. No med. Wakeful from 1.30 till 2.30 a.m. tJn waking in m. violent dry cough, with burning in eyes. After rising, pains in chest, burning under sternum. Sweats profusely on legs at n. During d. frequent violent coughing, with pain under sternum. — 13th, 100 drops. M., coughed several times, but not so violently. After breakfast, pressive burning pain under sternum. Several violent fits of coughing, ending in sneezing. — 14th, 100 drops. M., several violent coughs with expectoration of mucus. After breakfast, sore pain under sternum. After a loose stool burning at anus. When smoking, disgusting taste, feeling of flatulent distension of abdomen. — 15th, 100 drops. M., loose cough. Soon after dose discomfort in stomach. Eructation of air, weight and tightness in scrobiculus cordis, then drawing and tension in occiput lasting all forenoon* Occasional violent fits of coughing. — i6th. No med. Slept ill owing to pressive pain in crown. While lying awake grew suddenly

F%cary of life that death appeared desirable^ though there was not the slightest moral cause for this feeling. After dinner bctjan to cough and sneeze so violently that he had to cry out, — i7th. No oicd. M*, coughed a few times^ followed by sneezing. After dinner violctic fits of coughing followed by sneezing* The sneezing follows the coughing so rapidly that he often cannot tell which is which. The nasal secretion is increased, — l8th, loo drops. M., several coughs and sneezes, later some fits of coughing with retching. — 19th, 100 drops, M, coughed several times with mucous expectoration. — 27th. The last week was spent in the country, and no med, taken. Remained pretty well, but was troubled with severe headache on r. side, and almost all the time with cough of the usual kind, — 28ih, 100 drops* X)uring d, several sudden fits of coughing. — 29tb, 100 drops, M.> ccasional coughing o( the same kind as before. After breakfast, di$.

^comfort in hypogastrium- Afternoon, frequent violent fits of coughing^ followed by sneezing, — ^30th, 100 drops. Snoring and wheezing in chest during sleep. On waking frequent *loose cough and blowing of

^tnucus from nose. During d, repeated coughing. — ist Oct,, too drops, M , coughing and sneezing. A copious loose stool, afterwards some pinching in bowels, discharge of flatus. During d. several fits of violent cough, with little expectoration. Afternoon, a fit of coughing with vomiting. — 2nd, 100 drops. Several fits of coughing during d, — 3rd, lOO drops, M., mucous cough. Forenoon, blowing of mucus from nose. Noon, very violent cough, with repeated sneezing. Afternoon, fits of coughing,— 4th, too drops. Mucous rattles in chest at n. M., raucous cough. During d, several violent fits ot coughing, generally with mucous expectoration, — 5th, 100 drops. Mucous rattles in chest at n. M., cough with mucus. — 6th and 7th* No med. Occasional fits of coughing, — 8th, 100 drops. When lying on back mucous rales are heard, coughs occasionally, sometimes with mucous expectoration. When he yields to the cough it becomes so violent that he must cower together, tears come out of eyes, and saliva is ejected from mouth. Afternoon, itching on crown, where there are several spots with narrow borders. — 9th, 100 drops. Some severe cough at n. After dose, pressure in stomach, discharge of fiatus. Forenoon, several violent fits of coughing. — loth, 100 drops. M,, mucous rales in chest. Then several violent fits of coughing, but rarely expectoration. A firm stool, followed by burning at anus. For several d. the urine after standing a short time has become turbid. — nth, 100 drops. When asleep perspired profusely in r. leg, mucous rales in chest, M., cough with little expectoration. On awaking, severe pain in I. maxillary joint, he can scarcely open mouth ; later it is relieved, but does not go quite away. Much discharge of flatus. During d, frequent fits of coughing. On crown many small painful pimples, as also on back. — 12th, no drops. M., occasional cough with mucus, pain in 1. maxillary joint still there, but not so severe as yesterday ; it is most felt when opening the mouth wide as in yawning. — 13th, 120 drops. M., occasional coughing of mucus. Soon after dose discharge of wind upwards and downwards. During d- occasional violent cough. Pain in jaw much less. — 14th, 130 drops. M,;, loose

Its

cough. Pain in jaw gone. During d. several fits of coughing. Spots on crown. — ^i5th, 140 drops. M., some mucous expectoration. Soon after dose transient weight in abdomen. Forenoon, several violent fits of coughing. — 16th, 150 drops. M.^ mucous cough. During d, several fits of coughing, — J 7th, 150 drops. M,, a few loose coughs. Burning on skin of r. leg. Burning on crown after breakfast, weight in abdomen, which goes off after a copious loose stool. — ^iHth, 150 drops. M*, coughed a few times. After breakfast, weight in hypogastrium. During d. several fits of spasmodic cough, — 19th, 160 drops, M,, a few loose coughs. Forenoon, several fits of coughing ending with sneezing. Much mucus blown from nose. — 20th, 170 drops. M., several loose coughs. Immediately after dose rumbling in stomach and bowels, wind discharged upwards and downwards. Weight under navel. Hot fecline in head, especially crown^ also in eyes. A copious loose stool, followed by voluptuous itching, then burning, in anus. For some time copious secretion of ear-wax. — 21st, 180 drops. M,, loose cough, itching on hairy scalp. Noon, pressure and discomfort in abdomen, especially about navel. Forenoon, several violent coughs. Noon, great itching in anus and burning in r. leg. — 22nd, 180 drops. After dose, burning in stomach, then weight in abdomen. After breakfast, very disagreeable sensation in stomach, as of pressure and burning, thereafter rumbling in bowels. All forenoon peculiar uneasiness in stomach and abdomen. — 23rd, 200 drops. At n. very little cough. After breakfast, distension of abdomen, bad taste. During d, occasional spasmodic cough. — 24th, 200 drops. Great sexual excitement. After breakfast, distension and weight in abdomen. Cough with sneezing — 25th, 210 drops. Slight cough. M., after the dose emission of flatus. Burning in stomach, then gradually in bowels. All forenoon constant discomfort in abdomen with distension. Slight burning in anus. — 26th, 210 drops. M,, pressive pain in crown. Forenoon, after eating plums, pressure in stomach, great confusion of head. — 27th, 2io drops. M., mucous cough. After breakfast, weight in hypogastrium. Emission of flatus, some fits of coughing during d, — 28th, 220 drops. Vague sexual desire, M,, mucus in chest* During d., some violent hts of coughing. — 29th, 230 drops, immediately after dose scrapy feeling in throat. Weight in hypog^astrium. All forenoon indescribable discomfort. Little cough. Afternoon, acute pain in a corn. — 30th, 230 drops. M., occasional mucous cough. Eruption of vesicles on upper lip. Forenoon, some fits of coughing, — 31st, 240 drops. After breakfast, weight in hypogastrium. Emission of flatus. Several coughs with mucous expectoration. A loose stool, followed by rumbling in bowels. Eructation of air, later weight in hypogastrium. — 1st Nov., 240 drops. Coughed several times, with expectoration of mucus. After breakfast, weight and discomfort in abdomen, rumbling in bowels. Emission of flatus. Forenoon, when silting, slight oppression and stitches in chest. — 2nd, 250 drops. M,, some mucous cough. After dose, emission of flatus. — 3rd, 230 drops. Mucous cough, m. After breakfast, weight in hypogastrium. Forenoon, repeated but momentary attacks of vertigo, more in open air, less in room. Noon, slight pinching in belly, emission of flatus.

i86

I \

After dinner, burning In r, leg. — 4th, 260 drops. M., mucous cough. After dose, flatulent distension of abdomen> emission of flatus. — 51b, 27a drops. Mo itching on head, mucous cough. After breakfkst^ weight in stomach and hypogastrium. Pressure in na^al hones. All d. frequent, exhausting, mostly dry cough. — 6th, 270 drops. M., mucous cough. Burning tn r. leg. After breaklast, discomfort ia stomach, yery bad taste. — 7th. No med. Though more mcd. has been taken the last period, not only did no new symptoms appear, but the former ones gradually disappeared. — 8th. No med. M , some mucous cough .^-9th. No mcd. Cough entirely gone. — loth. No mcd. Occasional spasmodic cough. — nth. No med. Cough slighter,

^, 22nd. — As health was completely restored, commenced trials of the 10, dil. M,, to drops. Soon, emission of Batus* — 23rd, 10 drops. M., very violent pressive drawing pains in 1. tibia, slight pinching in bowels. After breakfast, rumbling in bowels, eructation of air. Forenoon, when walking, pains in tibia disappeared, but returned, noon, when sitting. — 24th, 10 drops. M., pain in I. tibia i forenoon, when walking, this went off noon, returned for a short time. Afternoon^ tiequent violent cough* £., severe burning pain on dorsum of 1. foot. — 25th, 10 drops. M., severe pains in 1. tibia. After breaker, rum* bling in bowels, emission of flatus. Forenoon, frequent, very violent cough. E., when sitting severe pains in dorsum of I. foot. — 26tb, 10 drops. M., soon pains begin, last all forenoon with intermis* sions, worst at noon, diminish afternoon and e. These pains are chiefly in 1. tibia, but appear sometimes in 1. elbow. The pains arc relieved in warmth of bed,^27th. No med. M.^ the pains returned, but more in r. than L tibia. Occasional cough dunng the d. E., pains in leg, but slighter. — 28th. No med* M., quite well, later slight pains in both tibiie. — 29th, lo drops. During d. occasional cough and slight pain in r. leg. — 3othj 10 drops. Immediately, emission of flatus, some tenderness in tibiae, but no pain. During d. occasional cough. — ist December, 10 drops. M., on rising, slight pains in tibia, — 2nd, 10 drops. Soon after rising, pains in both tibiae, which soon went off. — 3rd, 10 drops. M., slight mucous cough, emission of flatus. — 4th, 10 drops, M., emission of flatus, burning pain in r. leg, as if an ulcer would form, eructation of air. — 5th, 10 drops. M., burning on both legs, which went off when got up. — ^6th, 10 drops. M,, burning on r, leg, — 7th, lo drops. M., emission of much flatus, distension of abdomen. — 8th. No med. On waking, griping in bowels, diminished after a copious stool, but rumbh'ng in bowels for some time afterwards. — 9th, 10 drops of gx dil. Forenoon, well. After dinner, severe burning pains on r. leg, loth, 10 drops. After dose much flatus emitted j corn on r, little toe very painful. Noon, slight griping in belly. — nth, 10 drops. M., much flatus discharged. Proximal joints of r. index and middle finger red and sensitive to touch, — 12th, 10 drops. Redness of finger joints gone. Noon, great pain in corn of r. little toe. — 13th, 10 drops. No symptoms. — 14th, 10 drops. Some burning on r. leg. Afternoon, severe pain in corn of r. foot. — f5th, 10 drops. No symptoms. — 16th, m., pressing pain on crown, burning in r. calf. Afternoon, for an h, tearing burning in r. thumb|

a pustule in whisker. — 1 7th, 10 drops of 8x diL M., occasfonal mucous cough. Forenoon, such severe pain in corn of r, foot he must limp. E,, when sitting, corn still very painful. Later when writing, a noise in 1. ear like a distant bell. — i8th, 10 drops. M,, in bed, pain \n corns. After breakfast, great discharge of flatus. — 19th, to drops. M,, repeated mucous cough, ^ — ^20th, ro drops. Immediately pinching in belly relieved by emission of flatus. — 2Tst, lo drops. M., pain in r. leg. Little cough. 22nd, 10 drops, formication in r. leg. Great discharge of flatus. — 23rd, 10 drops. Emission of flatus. Forenoon, coughed occasionally, — 24th, 10 drops. Soon^ weight and pressing down in hypogastrium, burning on r, leg. — 25th, 10 drops of 7X dil. M., mucous cough. Weight and burning in r. leg. Discharge of flatus, E., burning on r. leg. — 26th» to drops. M., severe mucous cough. During d. occasional burning on r. leg, — 27th, 10 drops. After rising some tension in r. leg. Discharge of flatus. — 28th, 10 drops. Hardly any cough. After breakfast flatulent distension of abdomen, discharge of flatus. — 29th, 10 drops- Discharge of flatus^ weight in abdomen, burning on r, leg. — 30th, 10 drops. On waking, sudden call to stool, evacuation of large, tough, sticky excrement, after which rumbling in bowels, burning in r. leg. During d., slight hardness of hearing of 1. ear — 31st, 10 drops. Perspiration on legs. — ist January. No med. No symptoms. — 2nd, 10 drops. M., occasional mucous cough. After breakfast, weight in hypogastrium. — ^3rd, 10 drops of 6x dil. M., little cough. Severe pain in corn,— 4th, 10 drops. M.» occasional mucous cough. — 5th, 10 drops. M,, great flatulent distension of abdomen. Noon, sudden violent pains in 1. side of chest, over a hand's breadth space, lasting more than an h,, then suddenly disappearing.^ — ^6th, 10 drops. Distension and rumbling in bowels. — 7th> 10 drops. M., severe sacral pain, drawing, stretching. After breakfast, very bad, bitter, resinous taste. — 8th, ro drops. Some burning on r. leg.— ^th, 10 drops. Severe pains in r. corn. — lOth, 10 drops. No symptoms, — nth, to drops. Occasional mucous cough- — 12th, 10 drops of 8x dil. M., mucous cough. Great discharge of flatu'^. — 13th, lo drops. M., pressive pain in crown, repeated sneezing, discharge of flatus. — 14th, m., mucous cough. Soon after dose great rumbling in bowels, — 15th, 10 drops. After breakfast, distension and rumbling in abdomen. — i6th, ro drops. Tearing in L shoulder. — r 7th, 10 drops. M., great discharge of flatus. — 18th, id drops of 4X dil. Soon, slight pinching in abdomen, discharge of flatus. — r9th, JO drops. Forenoon, occasional pressure in umbilical region. Frequent fatiguing, dry cough, caused by irritation in trachea. — 20th, 10 drops* M,, on waking, violent, aching, pressing pain in crown, going off gradually in open air. — 2 1st, ro drops. M., great disch^irge of flatus. — 22nd, ro drops. The corn on r. little toe very painful. After breakfast, distension of abdomen, rumbling in bowels. — 23rd, 10 drops. After breakfast, rumbling in bowels ; discharge of flatus. — 24th and 25th, 10 drops. No symptoms. — 26th, lo drops of 3X dil, M., pressure in facial bones, especially orbit. Dryness of nose, burning in r. leg, discharge of flatus, — 27th, 10 drops. Rumbling in bowels, eructation of air, discharge of jacus* — 28th, 10 drops. M,, great discharge of flatus. After dose,

flatulent distension and tenderness in abdomen, great paina in r. com. Pressure in stomach. — 29th, 10 drops. M., much flatus discharged, n,, occasional tearing pain in r. tibia, — 30th. No med» M., paia in r. tibia. — Jist, 10 drops. M., in bed, frequent violent cough with phlegm. Some burning in r. tibia, — 1st February, 10 drops. M., cough with phlegm. After dose, rumbling in bowels. — 2nd, No mcd- All d. wclL — 3rd, 10 drops. After dose, distension of abdomen. Koon, transient pressure in anus.^ — ^4th, to drops. M., drawing in r. leg. Repeated violent cough. — '5th, 10 drops* After dose, eructation of air, discharge of 6atus. Burning and sore pain in skin of r, hand from wrist to thumb and index, nothing to be seen, but part so icr that mere stroking with finger caused pain* Noon, heat and iter .. in anus. — 6th, 10 drops, M*, great discharge of Hatus. Cough with phlegm. After dinner, qualmishness in stomach, rumbling in bowels. — 7th, 10 drops. N., repeated violent cough. After dose, discharge of flatus. Afternoon, frequent pressure in chest, here and there, swelling of neck, feeling as if neckcloth were too light.^ — 8th, 10 drope, 2x dil. N,, many vivid dreams. Immediately after dose, weight in abdomen. During d., severe pains in corn, occasional cough. £., great distension of abdomen^ rumbling in bowels. ^ — 9th, 10 drops. After dose, distension of abdomen, discharge of flatus. Repeated cough with phlegm. — loth, 10 drops. M,, discharge of flatus. Cough with phlegm. — 1 ith, 10 drops. Woke with headache, from aching^ pressing, limited to crown. This went off gradually after risineH Cough with phlegm. Discharge of flatus. — ^iith. No med, M., repeated cough with phlegm, burning in r. leg. — 13th. No mcd, M,, cough with phlegm.— 14th, 10 drops, 2x dil. M., cough with phlegm. Noon, rumbling in bowels, slight pinching about navel. — 15th, 10 drops. M., cough with phlegm. After dose, weight in hypc»gastrium. — i6th, lO drops. Profuse perspiration on leg. M., cough with phlegm. A small vesicular eruption on r, ala nasi. — 17th, 10 drops. On waking violent aching pain in crown, relieved by rising ; discharge of flatus. Burning on r. leg. Blows much mucus from nose. — iBth, lo drops. After breakfast, great flatulent distension of abdomen. Burning on r, leg. After dinner, distension of abdomen. — 19th, 10 drops of I, diL Woke with pinching in belly, followed by two liquid stools. Perspired profusely at n., especially on legs. After breakfast, again pinching in bowels. — 20th, 10 drops. After dose, flatulent distension of abdomen. After breakfast, severe pinching tn hypogastrium.~2ist, jo drops* After dose, pinching in bowels.^ — 22nd, 10 drops. M,, cough with phlegm, A copious loose stool. Forenoon, frequent distension and discomfort in abdomen. — 23rd, jo drops. After dose, griping in belly, pain in crown. — 24th, 10 drops. Soon after dose, distension of abdomen, slight rumbling in bowels.^ Burning sore feeling on back of r. hand near wrist for some hourM Afterwards same sensation on 1. hand. — 25th, lO drops. M,, some* mucous cough. Immediately after dose, the usual peculiar sensation of flatulent distension and weight \n abdomen. Some relief by discharge of Hatus. Atter dinner, weight and slight pinching in abdomen, wit^ iacftcctual urging of flatus against anus. — 26th, 10 drops. Soon after

dose, pressure and rumbling in bowels. M., some mucous cough.— 27th, 10 drops* Soon after dose, great flatulent distension of abdomen^ discharge of much inodorous flatus. An h* after breakfast sensation of burning and twisting in stomach. — 28th, 10 drops, M., mucous cou^h, itching in scalp, discharge of flatus i noon, weight in abdomen. — 29th, 5 drops of tincture. Immediately weight tn abdomen, urging of flatus against anus. After a while empty feeling in stomach. — ist March, 5 drops* After dose, weight in abdomen, discharge of flatus. Some mucous cough. Forenoon, frequent sneezing. Noon, drawing pain in both tibiae. — 2nd, 10 drops. After dose, discomfort in stomach, discharge of flatus. During d. occasional cough. ^ — 3rd, 10 drops. After dose, slight pinching^ discharge of flatus. — ^^th, 15 drops. Immediately distension and weight in abdomen. After breakfast, slight pinching, flow of water in mouth, some transient tearing in shaft of r, ulna, also in r. tibia ; attack of nausea. — 5th, 15 drops. Soon, pressure and nausea in stomach ; tension in abdomen ; flow of water in mouth. — 6th, 15 drops. After breakfast, for some time distension of abdomen. — 7th, 20 drops. M,, mucous cough. After dose, and especially after breakfast, nausea, very bad taste. Distension of abdomen. — 8th, 20 drops. M,, some burning on r. leg. — gth^ 20 drops. After dose, weight in abdomen, discharge of flatus. — loth, 20 drops. After dose, pressure and weight in stomach. — nth, 30 drops. After dose, weight in abdomen.— 1 2th, 30 drops. An hour after dose, pressure, weight and oppression of chest. — 13th, 30 drops. After dose, discharge of flatus, distension of abdomen, rumbling in bowels, tearing in r. shoulder, this tearing very severe on pressure, — ^i4th, 30 drops, M., much cough. After breakfast, rumbling in bowels, discharge of flatus. — 1 5th, 30 drops. After dose, flatulent distension of abdomen, — 16th, 35 drops. After breakfast, some pressure in stomach, rumbling in bowels, discharge of flatus — 17th, 35 drops. Soon after dose, flatulent distension of abdomen. — i8th, 40 drops. M., some mucous cough; flatulent distension of abdomen, discharge of flatus. — ^igth, 40 drops. In n, copious perspiration on legs. After breakfast, rumbling tn bowels, pressure on chest. — 20th, 40 drops. All forenoon, empty feeling in stomach, pressure and qualmishness in abdomen. — 21st, 40 drops, M., frequent violent cough, sometimes with raising of phlegm. — 22nd. Coughed much dunng n. The cough lasted for 14 d., gradually diminishing, and then ceased entirely, as also all the other medicinal symptoms. {Ibid,)

F» J. N, ZoTH, medical student, began his trial on 14th October, with 10 drops tincture, and increased till the 22ml up to 90 drops, but observed no effects except increase of stools. — 23rd, 100 drops. In 12 m. pain in sacrum as from haemorrhoids, which gradually went off. — Up to 4th November increased the dose up to 150 drops without any particular effect. — nth, 200 drops. No effect. {Ibid,)

II, Poisonings* — 1, A girl, aged 8, ate one bug-agaric in e., and six

• Many more cases might have been given if the effects of other poisonous muj^h* rooms had been recorded. As none of these, however, have been provcdj and as A. mu^eurius fairly represents their toxical influence, it has been thought better toconline ourbtlvcft to the etiects of this i^pecics, in using which we are on safe ground « — Eos.

§90

more next d* at 3 p.m. About 5, in moving across room, cried out that she felt giddy, and instantly fell down senseless and motionless. When carried to bed she uttered a wild cry» and her eyes looked fixed. Emetics were given without eiFect, At 6.15 she was stretched out in bed comatose, countenance somewhat swollen and of ghastlv leaden aspect i pulse greatly intermittent and tremulous, and scarcely to be felt ; eyes pulled up towards angles of orbits and fixed immovcably ; occasional starlings of limbs, and severe convulsive motions of head and upper part of trunk. There was complete unconsciousness. The whole body was unusually cold ; heart's action greatly laboured* Cold water was now dashed on the chest. Making a sudden start, which raised her head from the pillow, she opened her eyes, and for a few seconds stared wildly around. She quickly relapsed into her former lethargic state ; the convulsions became more violent, longer in their duration, and recurring at shorter intervals ; and the coldness and rigidity were extreme. Stimulants were used, and cold affusion repeated ; latter was followed by a violent movement of upper part of body and a wild kind of scream, and pulse became for a little more regular and fuller. A turpentine enema brought away a fcctid copious motion. Stimulants were continued, and pulse became regular, but weak and quick (above 130). After 3 h., she was put into a warm bath for 10 m,, and pulse became fuller and less quick (80), Mustjrd ■ ivas applied to stomach and soles. Soon a general perspiration broke out, and warmth of surface increased j extremities were even mo e convulsed, and muscles of calf became permanently contracted, and felt rigid and hard ; but upper part of body was much less affected than at first, Pulse got quicker again, seldom continuing steady for ^ h«, but breathing was natural, save for an occasional emission of a strange sound. The mustard was removed after 2 h. ; some colour appeared in face, and she seemed much better ; startings of limbs occurring ]cs5 frequently. At midnight skin was moist, body more warm, pulse 125 to J30 ; in 20 m. she was in a sound sleep, breathing easily, face a little flushed, and convulsions affecting her at longer intervals. No change, save copious sweat, till 5,20 a.m., when she hrst opened eyes arid turned ihem in orbits, seeming to look around herwiihout any consciousness of perception. She then fell back again and slept till 6.45, when, suddenly starting up, she threw down the bedclothes, calling out at same time to take them off from her, and seemed quite sensible. She then vomited some of the mushrooms ; asked for drink, and complained much of soreness of head and neck, so that she could not swallow. Afterwards she vomited more, and had ineffectual retching. In m. her pulse was 120, weak, but regular. Now and then during d. she had involuntary motions of legs. Thirst considerable j pulse in afternoon no. During n, slept as usual, but with frcmient startings. Pulse variable for some d. longer. {]. Adam, Lend. Mid. and Phys, Jmm.^ xxxii, 364.)

Dr. JoH. Heinr.Beck relates : — A schoolmaster, aged 73, drank, at 9.15 p.m., by mistake for pure milk, half a pint of milk m which was a decoction of 4 a plant of agar. muse. Perceiving his mistake he drank a quantity of warm milk, whereafter he vomited ^.9 timcs> and

had five diarrhcEic stools. He seemed to be half stupefied^ but complained of nothing but acidityj which was relieved after vomiting* He remained in this state till 4 a.m., when he became worse, and died at 5 a.m.

P.M. Skin of body yellow. Blood-vessels of scalp full of blood. All the blood-vessels of the dura mater full of dark red blood. Arachnoid red. Blood-vessels in cerebral sulci full of blood. Cortical substance o( brain reddened ; medullary substance studded with red points. Each of the cerebral cavities contained about a teaspoonful of bloody serum j the vascular plexuses were bright red ; the vessels of base of brain distended with blood J the tentorium cercbelli very vascular j the cerebellum very soft ; in the arbor vitje an effusion of blood the size of a smalt bean* All the fauces, oesophagus^ and trachea highly inBamed. Pleura and pericardium highly inflamed (stark entziindet). Lungs greatly distended (aufgetrieben), marbled blue, hepattzedand filled with black blood. Cavities of heart filled with black fluid blood. The arch of the aorta outside and inside highly inflamed, studded with atheromatous deposits. The omentum, pancreas, peritoneum and outside of stomach and jejunum uncommonly highly inflamed, all blood-vessels filled with black fluid blood. The inside of bladder very highly inflamed.^ {Henki^i Zeitsch. fur die StaatiarT^neikundt^ xxi,

307O

a. Three half-starved soldiers in the retreat from Moscow in 1812 made a meal of agar, muse, which they roasted on the coals, with a little butter and salt, and ate without bread. One ate four, the two others three each. They then lay down to sleep. At 10 p.m., the first soldier commenced to speak nonsense, passing from one subject to another in a gay delirium with great loquacity, borne time afterwards he had violent convulsions. Seen soon after he was found with convulsive movements of muscles of face and extremities, the jaws were firmly clenched, he could not be got to take anything ; he always wanted to talk, but could hardly articulate. His eyes rolled in their orbits, and were sometimes quite turned up. The agitation was extreme, the lower limbs strongly retracted, and the arms so agitated that his pulse could not be felt. Cold sweat on face, neck, and chest. Tip of nose and lips bluish. Some froth at the commissure of h'ps ; respiration oppressed and noisy ; breath had a sickly and sour odour* In an instant he became more calm, and the jaws were loosened. An emetic was given. He threw up much phlegm, which smelt sour, together with fragments of the fungus. He then got vinegar and water to drink. He passed the rest of the d. alternately convulsed and in stupor. The beginning of the n. was restless, but he grew quiet, and in the m, was as usual.

b. The second was attacked by convulsions soon after the first with great anxiety and pain at epigastrium, which was relieved spontaneously by vomiting. He then developed much strength with gay delirium ; he sang and talked, but gave no replies to questions. He imagined himself an officer commanding at drill, and various manceuvres

^ All the^e high itiflamtnatlons must be exaggerations \ probably he meaot congesliou Of trdncsfi, — Kds.

which he thought he was conducting. The convulsions ceased foral short time, but soon recommenced; irregular and hurried movcmentij of the upper extremities j restlessness of hands, which he pn together as though he was rolling a soft body between his hands order to make it round. Speaking with volubility and animation to] his father and mother, as though he were beside them, giving no repllc to questions, he sang and lamented alternately, embracing hjs comradclj and kissing their hands. All this took place in the midst of a generjl spasm resembling trembling rather than convulsions. Half an h. later he fell into a faint, which did not last long, but left him in a d«p| stupor. Extreme alteration of physiognomy, general prostration, willij cold clammy sweat all over the body. The scene ended in a soporou state, from which he gradually roused and recovered, but remembered"' nothing of what had happened since eating the fungi.

c. The third was seized with some pains which he referred to the stomach, with great oppression, then convulsive movement that lasted but a short time, but was violent, and was succeeded by a yellow tinge of the whole body, a kind of jaundice, most apparent on the face, neck and chest. Soon he vomited spontaneously a great quantity of fetid matter, and had some stools which relieved him greatly. Wheii^ seen he was very feeble, pulse scarcely perceptible. The rest of thM d. was found in a state of stupor and spasmodic agitation, but he slepfl well at n., and next d. was well. The yellow colour disap{>eared in jfl few d. (Vadrot, Ohs, sur F empoUonnemmt par ks Champignons^ iSi4.]fl

4, a. Five soldiers, after eating plentifully of the fungus, were a ttackcM by the usual symptoms. About 5 or 6 h. after their meal they perceive^ the first symptoms. After anxiety, oppression, general malaise, mm some convulsive movements, two of them had spontaneous vomitin J which was kept up by means of hot water. The violent symptoixH went off^ and there remained general prostration, stupor mingled witH spasms^ and later some faecal evacuations. This state lasted 7-8 h., when they rallied, and the next d. were quite well.

b. The three others had more serious symptoms ; one especially^ of feeble constitution and only just recovering from an internal disease^ had extreme prostration and delirium greatly resembling that of ataxia| fever. Tartar emetic was administered, but the alarming sy mptomifl persisted for a long time. The abdomen was tympanitic, he had verjl foetid evacuations from the bowels, the pulse was extremely feeble, and^ fainting fits frequent, a soporous and spasmodic condition lasted nearly 2 d> and the convulsions were protracted ; he could not go back to his military duties for a fortnight. ,

f. The two others had delirium, with increased manifestation of strength j the convulsions were violent, the oppression and contractionof larynx made suffocation imminent ; there was very painful tension at epigastrium, frequent nausea with very violent pains in stomachs piercing cries, extreme thirst. Vomiting was artificially excited, and was followed by transient calm \ then the pains returned so violenUv that the patient screamed out and rolled on the ground. The thif« was unquenchable, the features decomposed, the pulse imprrcepttblefl were taken to the hospital and given various remedies. Thfl

They

'93

pains subsided gradually, and the disease terminated in a dysentery^ which, and the stupor, ended in 5 d. [Ibid,)

— a. Two soldiers ate the fungi for their breakfast. They were attacked at the same time with gay delirium. One was very loquacious, while at the same time he had strong convulsions of muscles of jaw and neck, particularly the r. side, which drew his head over to r. shoulder. At the same time he had successive flexion and extension movements of the lower extremities, but he was able to walk though in a singular manner ; he thus marched about gaily, talking many unconnected things. To this state which lasted A h* succeeded a calm which was soon troubled by nausea and general malaise. He got tartar emetic and vinegar and water. The confusion of mind and quiet delirium lasted the rest of the day. He had a quiet night, and next day he had no remembrance of having been ill, but thought he had been a journey*

i* The second was delirious for a short time, but soon his gaiety was changed into suffering, and he had anxiety and a severe pain in epigastrium, oppression, faintness ; vomiting, artificjally excited by warm water or tickling throat, caused relief to the pain. He was extremely weak, had painful tension of abdomen, physiognomy much altered, pulse small, depressed, slimy yellow stools with tenesmus and pain. (Ibid,)

6, Several soldiers ate a quantity of the fungi they found in a forest. All were taken ill, some 3 or 4, others 5 or 6 h.^ others still longer after their meal. Those first taken ill got an emetic, and soon recovered.

a. Two had much more serious symptoms than the rest ; their abdomens became distended, painful, pulse feeble, depressed, frequent successive attacks of convulsions or faintings, physiognomy much altered, breath fetid, with an acid flavo^ur, partial cold sweats, very fetid stools. They got an ether draught, and had more stools of the same character. In the afternoon the violence of the symptoms diminished, and there ensued delirium, then a comatose state that lasted till the next d., which was passed in much the same state. In the evening the mind seemed to get rights they slept well at night, and next day were well,

h. Four others, who had eaten a large quantity, thought they were so strong that they would not take an emetic* Towards the evening they had excessive pain, anxiety, suffocation, fainting, extreme thirst, colic, small irregular pulse, general cold sweats, altered features, violet colour of the tip and alac of the nose and also of the lips, general trembling, tympanitic distension of abdomen, evacuation of very fetid stools. They were taken to hospital, but grew worse, delirium and severe pains lasted till their death, which occurred in the course of the h.

f, P.M. — ^Thc first had ejection from mouth of frothy matter of blackish-green colour, abdomen tympanitic, stomach and intestines distended with very fetid gas, their m.m, showed signs of inflammation and gangrenous spots, the jejunum showed in several places destruction of its m.m, ; stomach contained a little blackish fluid, the intestines slimy matter.

The second was in much the same state, except that the !$tomach ihowed signs of inflammatory congestion of its mjn» near the pyloric

»3 J

orifice, the liver was prodigiously swollen, the gall-bladder filled with thick dark-coloured bile.

The third also showed the same changes as the first, but more marked ; there were broad gangrenous patches in stomach and intestines,

{Ibid*)

The following occurred in 1853, and as far as we know is unique. The action of these unknown mushrooms resembles that of the well known amanita muscaria* Mr. C. S — , an accomplished civilian, of very temperate habits, was ordered out of the collector's court at 1 1 am., in consequence of being apparently drunk. On the following morning he was seen by Dr. Palmer, who reported as follows ; ^M found him in a state of great depression and distress from the recollec tion of the occurrences of the preceding d. He informed me he had had his breakfast as usual, had a small bottle of claret which he always took, and was not aware of having partaken of anything unusual, and certainly not to excess. That he went to Cutcherry at the usual h*, and felt unable to control his actions \ felt drunk, every thing and person appeared ludicrous ; he laughed immoderately in open court, joked with the attendants, and ridiculed in an absurd way his superior officer, the collector, by whom he was taken to his house. After some h. he recovered, considerably depressed from the effects of the stimulant, and from the feeling of shame at having made such a ridiculous spectacle of himself before his court, but more so, as he assured me that this was the third time a similar attack had seized him, and he feared he would go mad, for he could not with the utmost effort control his actions, and had been seized in precisely the same manner, at the same time of the year, three years in succession."

Dr* Palmer, to console him, promised to return to tiffin, at which, among other dishes, were stewed mushrooms. Before the meal was finished he became very excited, and as he had taken very little beer and no other stimulating drink, it suddenly flashed across his mind that^ the mushrooms were the cause both of his own and of his friend*! intoxication- His symptoms were identical with those described Mr. S — , and were very similar to the exhilaratory effects of alcohc Every person appeared ridiculous, the most ordinary remark was full fun and wit, and his immoderate laughter provoked equal merriment in others, " I took (he writes) a drive in the evening, and I never before or since have seen the lights and shades cast by the setting sun so brilliant, and every object looked so perfectly beautiful. These exaggerated sensations continued for some h,, until, at the request of my friend, I put an end to them by taking a full dose of ipecacuanha, and thus got rid of a considerable quantity of the fungi still undigested* I experienced no after ill effects whatever.'^ (Norman Chev£RS|^J Medical yurisprudtn€e\in India,) ^H

a. The first two cases were those of a man aet, 60, and his wife jet. 40»^^ who had eaten of a dish into which the fungus had been introduced. In 4 h. woman had trembling of stomach, weakness of limbs, nausea,

♦ Vadrot thinks that the fungi eaten were agar* muse., but in none oi the above cases did he sec the fungtts that caused the accidents. Of the last he says the sol iithcred a lot of different sorts of fungi and chose the brightest coloured^ doubdci^ , muM!* — Eds.

«er hat^

^95

and violent vomiting. She trembled all over and could scarcely hold

anything in her hands. She grew worse, got violent convulsions in the arms, almost like electric shocks. She felt as if her limbs did not |belong to her, her legs bent under her j at the same time she felt light "as if she could run with great quickness. She had dazzling before the eyes, was much excited, eyeballs rolled about j vision impaired, but hearing very acute. Towards e. convulsions ceased ; she had inclination to bend body backwards and forwards and to stretch; sleep restless. The man was much more ill. He had trembling, convulsions, retraction of neck and stretching of body, excitement and inclination to vomit ; his mind became clouded, he fell down and appeared to be dying. Pains in limbs, impaired vision, flatulence, colic and great thirst afFected both patients for 4 d.

h. The other cases were two carpenters, 70 and 50 years old, who after partaking of a similar dish of fungi were affected with the most violent brain symptoms ; they cried and roared like madmen j the elder was the noisier and broke his bedstead to pieces with superhuman power. It was with difficulty that four strong men could throw the furious patients to the ground and bind them fast. In spite of an emetic the most violent clonic and tonic convulsions lasted all d. It was not until the following morning that they became quiet, and soon after this they recovered. (Quoted from fVten. Mtd, Pusie in Hirschel's Z^;/ichr\fi^}\xxi^ 15, 1874.)

r 9. The inhabitants of the north-east part of Asia use agar. muse, in khe same manner as wine, brandy, arrack, opium, &c,, are used by other nations. The fungi are collected in the hottest months, and hung up in the air by a string to dry. The usual mode of taking the fungus is to roll it up like a bolus, and swallow it without chewing, which (the Kamtschatkans say) would disorder the stomach. One large or two small fungi is a common dose to produce a pleasant intoxication for a whole d., particularly if water be drunk after it, which augments the narcotic action. The desired effect comes on from one to two h. after taking the fungus. Giddiness and drunkenness result in the same manner as from wine and spirits ; the cheerful face becomes flushed, emotions of the mind are at first produced, involuntary words and actions follow, and sometimes, at last, an entire loss of consciousness. It renders some remarkably active, and proves highly stimulant to Linuscular exertion j by too large a dose, violent spasmodic effects are pproduced. So very exciting to the nervous system, in many individuals, is this fungus, that its effects are often very ludicrous ; a person under its influence wishing to step over a straw, takes a stride, or a jump sufficient to clear the trunk of a tree ; a talkative person cannot keep silence or secrets, and one fond of music is perpetually singing. (Langsdorf, Ann, d, IVetUranhchen GaelLf. d. Gts, Naturkunde,)

m. ExfirimenU on ammali, — i. a. Two ounces of fresh A. were beaten ud with Jij of tniik, and strained through linen. Of resulting mixture a torn cat (A) got at 4 p.m. Jiss, a female cat (B) Jj, and another (C) t^s. In 5 m. cats A and B began to mew, their gait was unsteady, they staggered, fell on one side or other, but got up again and ran from place to place. Atter running about in this way for J h. their gait became more unsteady, they fell more frequently, mewed often j then.

m>t being able to keep their legs, they lay on their side, mewing rontmtiotiiiy, thm limb* constantly moving a* if they wished to go along. At the same time there fntt movements in the abdomen » sometimes it was distended, sometimes condiaed^ dieo there wai retching and finally vomiting of their food mixed with mucus. Soon tht% wards brown .coloured loose faeces were passed, and the cat A pa»ed soine uniK. Vomiting and purging went on till 5 p.m. When the vomiting and purging ctiicd the limb* began to twitch, especially the hind legs, and they were often itrctchcd oui backwards. The head was bent backwards towards the spine. They often ittempted to get up, but immediately tell on the other side, and after such attempt the twttcnitte and trembling of the limbs became stronger. At 5,30 p.m, the body was often niiea up Without using the limbs. The mewing became less. On taking up the cat the head was bent more backwards^ and it trembled and twitched more. Refptratioa and heart** beats were Quicker, the hair stood on end and was lustreless. At 6 p.ra. ihey ceased to mew ana lay on their side, the front limbs were stiff, the hind limbi stretched backwards and the head bent ^ far backwards that it touched the sptne. Respiration much quicker, the thorax moved little, but the abdomen moved icrr strongly. At 7 p.m. they lay quiet with closed tearful eyes, occasional jerkings of the limbs and through the whole body. Respiration and heart's beats very quick. At S p.m. the same state ; when lifted, they started and began to mew. Thus they continued all n. Towards m, they became quieter, tried to raise themselves on their limbs, but were unable to do so as the trembling and jerking returned. If they luc. ceeded in getting on their legs, these were wide asunder, and if they tried to walk they fell on their side, i ith. — The cat A was most affected, it lay all the foreniaoo on Its side occasionally mewing, and could not get up. The jcrkings of the limbs and the movements of the front legs as if to get along increased. The hind legs wen oltcn stiff, sometimes stretched out backwards, at others drawn up towards the belly, when the back was very much bent, and the body with the head bent back was curved like the letter §. Towards noon the movements of the forelegs became strongtrk it endeavoured to get along, and moved itself on its side about in its cage. It often by exhausted with its efforts to move and mew, then the head was moved up and down, the limbs jerked and trembled, the eyes were da2€d,the temperature lowered, the feet cold. Hair on end and lustreless, heart's beats ver)' quick. No stool since yesterday. Urine passed once. At noon it got another ounce ot the mixture. At i p.m. it lay with the hind legs close up to the belly, extremities cold and jerking fi-equcntly. It lay as if dead, the neck stiff and stretched out forwards, eyes dazed, resp. very quick, heart'!i beats trembling. At % p.m. a liquid black stool. At 6 p.m. lies as if dead, the body all cold, heart's beats scarcely perceptible, rare jerks in the hind legs. All night it continued in this state, lath. — Morning, lay as if dead, quite cold, nesp. vei^ ouick and shorty died at 9 a.m. P.M. 4 h. after death. Vessels of the dura matei filled with black blood, nothing observable in brain. Lungs of black-blue colour, friable, and when cut into much black frothy blood escaped. Both auricles of heart filled with black coagulated blood. Stomach considerably distended with air lod digested food. The m. m. was red, very friable, and easily separated from the muscular coat. Vena porta; swollen and contracted so that the smallest sound could scarcely get through it. Small intestines very vascular and contracted. Their m. reddened in places, contained a yellow slimy fluid, Lar^ intestines blackish outsit and inside, contained much air» the rectum full of hard fscces. Liver friable and fiiU! of blood, bladder empty, spinal cord normal, only its membranes in the lumbar region redder than elsewhere.

The cat B could scarcely keep on its feet all the forenoon, if she walks a few steps she staggers from one side to the other ; the hind legs give way and she falls down on them, at the same time head and tore part of body are constantly moving from side to side as though she would fall. She does not mew, but cannot rest in one place, and tries to get along j the heart's beats and resp* quickened, hair lustreless and on end, will neither eat nor drink. In the course of the d, her gait became more steady, in the e. she ran about for some time and then suddenly rcll upon her hind legs. No stool, but urinated several times. In the e, she ate meat ajid milk. The following d. she was quite well and remained so till igth when she got ^ oz. of the above mixture. Soon the L hind leg was forcibly stretched out backwards for a few minutes. Soon afterwards the I, foreleg was suddenly lifted up, the flexor muscles contracted so that the toes touched the back of the foot» This lasted a few a '

uUH

onH

»97

The movement.^ of the hind legs were repeated at longer or shorter intervals for ) h,, then there ensued retching and vomiting of phlegm mixed with the medicine. The vomiting was violent and repeated thrice in a short time ; about a tableitpoonful was j thrown up. She soon began to jump about. This ]a5ted } h., then she fell down on her hind legs. The belly then was violently contracted and she passed a fima black brown fetid stool. While sitting thus the L foteleg was jerked up, the paw bent inwards, then again stretched out. In the intervals the fore part of the body moved from side to side. All at once the back part of the body was jerked up, the legs twitched, and she began to run about, and then fell on her side, and with difficulty she attained again the sitting position with her legs widely separated. In this position she swayed from side to siae. Whenever she attempted to rise the hind legs gave way, and she fell on her side. She mewed constantlv and was very restless. The hair on end, the eyes dazed, resp. and heart's beats quickened. So she continued till 4 p.m. I when she again commenced to run about but unsteadily* She had a fluid black stool. No urine passed. She coutd not eat. At S p.m. she was lively, lapped some milk, and became quieter. She did not mew much and the night was quiet.

The cat C, which got J oz,, had the same symptoms.

On the 19th, both cats were pretty lively, but their gait was unsteady, and their movements hurried f when they attempted to leap up un a stool, they jumped too high and fell off it. They ate enormously. On the lotn they were both quite well. So they remained till the lath November, when they both got at 8 a.m. 100 drops of tincture. Soon after they retched and vomited their food mixed with much yellow mucus. Then they became quite well. At 1 p.m. they again got 100 drops. Much white foam came from their mouths. The cat B passed a considerable quantity of urine, fell on its 1. side, the limbs trembled^ the resp. and heart's beats became always

3uickcr, and she was dead in J h. The P.M. after 4 h. showed the vessels of the ura mater full of black blood, brain normal. At apex of 1, lung a bbck spot the sixe of sixpence. Over the root of the lungs, especially in front, were many black points the size of pin's heads, which exuded black fluid blood when cut into. The auricles of heart and large vessels filled with black coagulated blood. Liver friable and full of blood, gall-bladder large. Stomach distended with air^ empty* The m, m* of stomach towards pylorus deep red and swollen. All the intestines distended with air. The small intestines contained slimy grecni&h-yellow fiuid, the large intestine some pale yellow mucus ; bladder empty, kidneys normal. The dura mater of spinal cord towards pelvis redder than normal. Spinal cord normaL

The cat C soon after getting the agar, sought the warm stove and sat there sad, with head hanging down, sometimes mewed for several minutes at a time. At 5 p.m. she vomited yellowish-grecn saliva. Gait unsteady, walks with legs wide apart and staggers first to one then to the other side, as though she would fall. The hind legs sectn the weakest. Half- an -hour after vomiting, when walking she was violently thrown on the I. side. She got up and had violent retching for Jh. She then attempted to walk but fell forwards on her head or on one side or other. Resp. and hearths beats very quick| hair lustreless and stands out like bristles. On t^th she was sitting sadly in a corner, with eyes gummed up and swaying from side to side, »oo drops were administered. On this she jumped forwards a few steps and fell down dead. P.M. 6 h, after death. Vessels of dura mater filled with black blood. Upper lobe of r. lung blackish f much frothy black blood escaped when cut into. Rest of lungs normal. Much black coagulated blood in large vessels and auricles of heart. Stomach distended with air, its m. m. reddened i intestines contained air^ yellow slime, and *ome thread.worms. Liver large, friable, and full of blood. No other changes observable.

A male and a female rabbit were experimented on. Various dilutions were given without effect. On 30th Oct. both got 100 drops tmcturc. All day they were Rvely, and ate well, the female passed urine frequently and copiously. 3ist.^ — Both got same dose. While getting it they foamed at mouth, no other effect observed* At I p,m. again 100 drops. At 1 p.m. they sat sad in their cage, would not eat, and had jerkings in the limbs. In afternoon they ran about as usual ; bo^h parsed but little urine. In the c, the female was allowed to escape. She was found dead in a meadow a week afterwards, isi Nov. — The male got at 8 a.m. 100 drops tincture. All day he sat sadly in a corner and his hind legs jerked much. In walking he dragged the hind legs. Forenoon and afternoon had a watery and slimy stool, and urinated frequently.

ied widi iaik Uool ^

ma cim. JU^i

of Imvivaiiiid. Tkc

, of finte. E. lie

TWase^oecwiftgirBi fear

g«t m dpter of aoo draft

l»tfOQl,Mdifec^P«lErwMespeile<L Alter ) b.

ihovK ma te I k^ 1^ dcma and dc^. Dof

I had mmk wmd MCHncd lo hSk asleep, sztdfig on

aBii ■'^epc Af to ajB. dog Ne. i started end*

ss rcKlled, aad thcs went to bU facd« Th^

At 1 1 ajB. tbe dyafeer was iep«atcd. Soon

of a bbckiib^<eIlo«r diany ftoid, less than the

~ ftoAM and licy as do^rfi. On bcmg

_.^ . rcowld<riAdifadQr»oi^ hiillqw^fiMHiLm letcyag and urging

Co^Wodl, wlikii owy icstod in n— iwg a hmitufmoilmmn tSimj laid. At 3 p.m. tthrner. Is 5 m.tiieclyilcr wvrivnafiedaad ilMiiwpiisix»siDi»i witliout All cbe reft of the dsf they myaincd sittii^ a» they weie not able ta iiand 00 btod kgi. Tbey ate rartaooibr. Empty ictdi^ and urging m stool without ttwilf occurred freottcntiy during aftemoop, Urmaiiott BotnaL tith. — Hind 1^ i^ratb«r untccady 10 m.,aU rieht ta e. i^th. — Quite light. f4th. — 400 drops ^en by mootb ; chn earned bum frothing in mouth and short cough* At 10 a^m. 100 dropt. Much frothy a]iri» conehing and retching. Soon aftenwds quite unsteady > the back part of body fwajcd from side to side, the hind legs seemed as if paralysed, they generally maintained the sitting posture. 1 p.m., too drops. Great empty retching often repeated during afternoon. When seated the forelegs were wide apart, the head swayed about ; when lying they had jerkings in limbs. By e, they were again lively and neat m. quite well. 1 5th Nov, — They got three time« soo drops. The same array of symptoms followed.

d. Two pigeons, a cock and a hen^ were fed from 9th to i4.th December with barley that had been soaked for 14. h. in concentrated agar, tinct. No effect. 14th and i5ih,— 10 drops given by beak ^ no effect* i6th, S a,m,, each got 10 drops. Soon they made a noise between coughing and retching. In | h, thejr walked un^te»<lfly» fell forwards on head or on one side or other; they got up again imme* diately and ran about staggering as if they could not rest anywhere. From to till 10,30 the cock lay on its side, but got up when one attempted to seije it. At noon thcv went into a comer, hung their head, and would eat nothing. In the night thev recovered, walked steadily, but could not eat. 17th, 8 a.m,j 30 drops. Soon, gajt unsteady, they staggered and fell on one side or other^ but instantly got up again, eructated air as ifthey would eject the drug, sat sadly in a comer, or ran about the rmxm iiaggcring. Thus they continued till 3 p.m., tnev then went into a comer and rtm^inctf there till the i8th, m. From i8th till sand they got daily the same doie with the same symptoms. On iind the hen died, and on the sjrd the cock. P.M*

of hen after 4 h. Body emaciated, crop and skin covering it I'ery- full of blood* vessels filled with dark blood. Crop empty, its lining membrane oi whitish-yellow colour, of greasy feel, easily separated from muscular coat, which latter was redder than normal. The passage from crop to gizzard was red and full of congested bloodvessels. The gizzard full of sand, its lining membrane dark green. Upper half of intestines brownish yellow, containing an acid green slime, with white things* the size of a hemp-seed. The lungs sometimes coloured, and containing little red froth. Auricles of heart and large vessels filled with black coa^lated blood. Liver friable and blackish. Vessels of dura mater full of black blood, brain and spinal cord healthy. PM. of cock gave precisely similar results.— {Z^i//ry;. des /'W. d, Aom» Afr%U Oestirr^uks, ii,)

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