Moschus

Volume III — Main text

MOSCHUS.

&lB{M«tted and dried secretion of preputial follicles of the musk deer, MojcHs

motcAt/rrujt L. Musk.

1. Provings. — I. HAHttEMASSy Mat. Mfd. Pura^vo, i of onginzl^ vol. ii of translation. Contains 2 symptoms from self, ill from three fellow-observers, and 39 from authors.

2. GuNTz, on Feb. 9th, 1824, at 9 a.m., took 5 gr. of musk mixed with I oz. of water. The only symptom produced was a slight pressing headache in frontal region which came on after 1 1 a.m., and vanished a few m. later. (JoRG, MaUrialien.)

3. KvEsCHiCE,on Jan, 4.th, at 9 a.m., took 4gr. mixed with 20 gr. of sugar and I oz. water. Towards 10 a.m. pulse was 74 as against 71 before taking dose ; pulse also appeared fuller than usual. These symptoms disappeared towards 1 1 a.m. Same results followed from dose of 6 gr. On taking 10 gr. felt after | h. slight confusion of frontal region, changing after 15 m. into dull frontal headache, most perceptible on r. side j after ij h. this spread towards parietal and occipital regions, and was here also more severe on r. than on 1. side. Whole head now felt somewhat empty and confused, and power of concentration was somewhat affected. This condition of head lasted till bedtime. Pulse all through was 2 or 3 beatsquicker, and fuller than usual. Repetition of dose caused same trainof symptoms, but lasting only 6 h. (Ibid,)

4. Martini took 5 gr. at 9 a.m., on Feb. loth. After i h. there was moderate quickening of pulse, increased feeling of warmth with some sweat and distension of veins of hand ; these lasted hardly i h. One h. after 10 gr. pulse rose for short time 8 beats per m. On going into open air noticed suddenly feeling of heat in r. cheek spreading to r. side of forehead, lasting barely i m. {Ibid.)

5. Otto, after taking 2 gr., felt slight confusion of head, which did not last long. After dose of 8 gr. relt moderate confiision of head passing on after x h. to slight headache, and accompanied by absentmindedness, which prevented his working for several h. After taking 10 gr. confusion of head followed, but was exceedingly slight. {Ibid.)

6. SiEBENHAAR took 10 gr. Onlv symptoms noticed were some quickening of circulation and rush of blood towards head, lasting hardly I h. {Ibid.)

7. JoRG, on Jan. 3TSt, at 9 a.m., took 10 gr, rubbed up with same quantity of magnesia and suspended in i oz. water. After \ h. felt slight oppression of whole head, bordering on pain, becoming better and worse by turns, and lasting till nearly midday ; at same time feeling of fulness in region of stomach came on, accompanied at 10 a.m. by upward pressure towards thorax and stabbing in 1. shoulder-blade. Pressure and stabbing ceased midday, but fulness in stomach lasted longer and interfered with enjoyment of dinner. Durine same period (10 — 12) pulse was quickened several beats per m. At 0 p.m. felt burning in

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chest in direction of diaphragm. He then took 15 gr. After i h, seized with slight vertigo, changing at times into moderate parietal headache, and accompanied now and then by painful pressure over both orbits and outwardly over both eyelids. At midday these changed into sleepiness, which was relieved by dinner. At 5 p.m. same feeling at pressure in forehead came on, lasting till nearly 7 p.m. {Ibid.)

1. Frau Ch — took 3 gr. in a tablespoonful of water on July 19th, at 8 a.m. At 8.30 slight confusion of head came on^ changmg for 5 m. into vertigo, then into pressure in frontal region, which passed 0 at 10 a.m. Pressure in forehead returned p.m., and lasted till towards

5 p.m. From 9 till 12 a.m. pulse was several beats per m. quicker than usual. At 5 p.m. on same d. she took 6 gr. in a tablespoonful of water. Soon afterwards felt pressure in region of stomach, coupled with sinking feeling. This pressure increased during 1 h., and was felt not only forwards but backwards to spine as if right through body ; it lasted uninterruptedly till midday following. At 5.20 head became confused, and later almost giddy, 50 that at 6.30 the meshes of her knitting appeared to run one into the other ; there was besides troublesome pressure in frontal region, increased by movement, and lasting also'till next midday. There was also drynesss in mouth and oesophagus noticeable for 16 h. Between 7 and 9 p.m., pulse was six to eight beats quicker than usual. I h. after dose was overpowered with sleep, and yawned deeply and often. Next m. felt very unwell j head still affected, trembling all over body, weight and pressure in stomach. At noon most of these symptoms passed off, but she was very sleepy all p.m., and slept from 1 till 3 p.m. On July 21st, at 7.30 a. m., took

6 gr., experiencing same symptoms. At 10 a.m, had confusion of head, slight giddiness, moderate trembling and shaking through whole body, and quickening of pulse. Appetite at noon was very slight, but pressure in frontal region, which came on forenoon, was all the more severe, and lasted until e. During p.m. had also nausea, sleepiness, and frequent yawning. Sleep was not so good as usual, and on awaking next m. had confusion of head, pressure in frontal region, trembling and lassitude of body, pressure at stomach, and dryness of gullet, lasting till noon. [Ibid.)

1. Fraulein Ch — took 3 gr. During next 2 h. said it appeared to her as if she had not slept properly, head feeling heavy and empty, and yawning occurring frequently. On same d. at 5 p.m. took 6 gr. After \ h. pressing sensation in stomach, pressure in forehead, and oppression in whole head came on > frequent yawning and sleepiness soon followed, and all lasted till lop.m. On repeating dose at 7.30 a.m. after i^ h. felt heavinessof head, passing after another 4 h. into genuine pain, perceptible especially in forehead, lasting till 10 p.m. From 10 a.m. till 1 p.m. pulse was somewhat quickened, strong and full. From 10 a.m. was obliged to yawn frequently; this increased during p.m., when lassitude and sleepiness were superadded. (Ibid.)

2. Th. JoRG took 3 gr. Noticed only hardly perceptible heaviness of head lasting 4 h. On same d. at 5 p.m. took 6 gr. After \ h. felt confusion of head, with slight frontal, alternating with occipital, headache, both lasting till 9 p.m. On repeating same dose ac 8 ;

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after 4 h. felt confusion and heaviness in head, passing on to pressing pains, especially noticeable in frontal region and spreading downward towards eyes and nose. Towards 9 p.m. remarked that gullet was unusually dry. These symptoms lasted till lo p.m. (Ibid.)

1 1. Mrs. — had been married a year, but had no pleasure in sexual intercourse ; otherwise perfectly well. Toole 4 dr. of M. {strength (ipt stated) every n.^ and had same quantity injected into vagina following n. Quantity swallowed later reduced to 3, 2, and finally i dr. Qn 2nd or 3rd a. from ist dose, dull pain in bones of 1. knee, afterwafc|s extending up to hip, and down to great toe ; still only in bones ; ease found in lying on painful side. This ceased a few d. after leaving oft" med. On resuming it 3 d. later — 3 dr. per vaginam and 1 by mouth — same symptoms returned, exactly as before, only on r. side instead of 1. No change in sexual organs. (Berridge, N. T. J. of Horn, ii, 308,)

1. a. Miss — took 30 dr. 6th cent, at 2.4.5 P-"™- At 2.55 sleepiness, stupid feeling in head. 2nd d. — In afternoon sleepiness with slig^it aching in forehead. 6th d.— Ever since, sleepiness with yawtili^g when not actively employed.

b. Same prover took 3rd trit. It caused inability to sleep. (Ibid., Jm. 06s., 1875, p. 307.)

1. a. Miss — , 1st trit. Oppression of breathing ; anxiety as if something were about to happen. Creeping on top of brain. Pricking in body and " fidgets,'* preventing sleep.

i>. Same prover, io — 20 dr. 6th dij. Tingling all over body ; low spirits ; very nervous. (IbidJ)

1. Mrs. — , 3 — 4 dr. 2nd dil. Made her feel quiet and self-possessed ; no fear of any kind \ is usually nervous and timid. (Ibid.)

Miss — , 3 dr. 2nd dil. In 15 m. a stupid feeling in forehead.

6th dil. In 5 m., flat tas^e , paroxysm of slight chilliness

(Ibid.)

1. E. W. Berridge, M,D., 30 dr. in mouth, lasting some time. In 35 m over body. (Ibid,)

2. a. A man, at. 52, triturated for i h, i gr. Mosch. with ipo gr. milksugar. In the first 5 m. a kind of rush of blood to head, with staring eyes and spasm in mouth, so that he could not answer when asked what was the matter, though he understood what was said. In the 7th m. he began to speak, and spoke 90 rapidly and so confusedly that it was impossible to write down what he said, and he would not stop when asked. Till the loth m. he was as pale as a corpse, and his hair dripping with perspiration. Vertigo as if intoxicated, he could not walk alone. Headache as if a weight lay on head, aggravated by movement. Roaring in both ears as from a strong wind. No memory, y«t he answered every question, but when the first question was repeated, he seemed to be endeavouring to remember something, and then gaye a wrong answer. Both eyes distorted upwards. Movement of Xovf^x jaw as if chewing something. Vomiting of phlegm 3 times successively. Severe pressure in stomach, followed by eructation smelling like a goat. Some rumbling in bowels, with discharge of fiatus of like smcU. Stiffness of penis and urging to urinate. Fingers of r. hand <}uite stitf. He was taken into the open air, and '\x\ \ h. all the syix)-

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ptoms were gone, and he then recommenced his crimrating and continued it for i h.

h. He was suddenly scixcd with trembling of whole body and profuse clammy sweat all over. Facial muscles distorted so that he was unrecognisable ; eyes staring, projecting beyond eyelids ; mouth half open, out of which white mucus flowed. After J h,, when sitting in open air, began to talk nonsense, spoke very low, and as if he would not disturb someone, saying " Bst ! Bst I Bst ! " Then he commenced to sigh deeply, and at same time played with the buttons of his waistcoat as if he would button and unbutton it. This lasted lo m., then he recovered his consciousness. During the trituration he felt a sort of stupefaction, and all the objects in the room seemed to him to be big black figures, which sought to press on to him ; otherwise he knew nothing. Vertigo, with a kind of loathing, not nausea ; a kind of pressive headache, combined with throbbing in whole back part of head, and some drawing as with a thread into the spine (down the cord to 1st lumbar vertebra). The whole head pains as if sore, worse when touched. Much sweat on forehead. Pressure in both eyes as if sand vrert in them. Black points before eyes. Severe tickling in nose^ going onto burning. Swollen upper lip, dry mouth, little thirst. Mouth very dry, longing for brandy, which he is never accustomed to drink. Burning in oesophagus as if a coal were there. Loathing at all food, and when he sees food he gets nausea and, if he does not go away, vomiting. A painful sensation as if something hard lay on stomach, aggravated by drinking. Distension of abdomen with violent urging to stool, but without being able to evacuate. Urine very scanty and turbid. (Hromada, journ,f. horn. JrzneimitttUihrey i, lo!.)

i8. A woman, ast. 45, after triturating i gr. of musk with J 00 gr. of milk sugar. In 4. m. eyes began to stare, face became pale, she complained of heaviness of head, pressure in nape, coldness all over body, a kind of nausea. In 9 m. lost her sight, pupils extremely contracted. Lost her equilibrium. The r. hand, which was using the pestle, became stiff, the fingers stretched out and quite stiff. Taken out into open air in 5 m. recovered her senses and complained of vertigo in the first moment. Before the loss of consciousness, all seemed to go round in a circle, at first slowly, then always quicker and quicker, and at last it seemed as if she was hovering in the air, stupefied, and when in this state it seemed to her that she fell from a great height. Vertigo as if intoxicated, everything seems to move that she looks at. Pressive headache in interior of brain. Head very hot, and back part of head perspiring profusely. Above both eyebrows 2 small red spots like flea-bites. Eyes dim, pupils dilated, tears flow out of L eye. In Lear a rustling and sensation as if a flea were in it. Nausea. Mouth very dry. Great thirst for beer, which she did not usually drink. Much eructation smelling of musk. Much flatus of a garlicky smell. Great diarrhcea, with retraction of abdomen. Urine clear as water and copious. The menses came on next d., a fortnight too soon. Very soon fluent coryza, with peculiar burning, first in r. then in 1. nostril. Very viscid mucus in chest without cough, which seems 10 take away her breath, because she cannot bring up the phlegm, relieved

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Very anxious dis-

drinking. StifFness of hands and feet. Cold knees. Blue spots all over abdomen and thighs position. After 2 d. quite well. (Ihid.^ I02.)

1. From triturating musk (no iDformiitioa 15 eo numben, sexes, ages of proven, or how, when, and where they triturated). After 3 m. — violent vomiting, diflicult breathing with ihooting in chc>t, which makc^ his breath short. He had great fear of death, and said, •* Now I am dying," became deathly pale and fell into a &int for 10 m. After 5 m. — vertigo with m&h of blood to head, tasting x h., bctte in open air. Ertictatlon with aflcr-tastc of garlic. Sneezing and prni^ive pain in nasal bones. Cold feeling of thigh and leg, more cxtcmaUy than internally, not perceptible to touch. She thought &he ^vas going to faint, then called out, " i am falling! " but remained sitting quietly. Fell fast akleeu. Very sleepy, and on lying down cannot sleep ; when walking in open air can hardly keep his eyes open, he is so sleepy. After 10 ra. — vertigo as if everything moved. Vertigo to iinconsciouincss. Spoke ofily of dying. Very violent scolding, cannot be appeased \ continues to ^cold tul his mouth Is quite dry, tips blue, eyes staring, face deathly pale, ajid fails to the ground. After 1 3 m. she sita in thought, speaks aloud, but unimportantly, to herself, and fights with her hands, then suddenly exclaims "Ah! Ah!*' After \ h. — menses, which had ceased for 1 year in a woman tet. 4.8, reappeared every time she triturated musk, but disappeared in a fetv h. Pains in ankle-joint as if dislocated, with shooting in 1 fir^t toes of 1. foot. Very profound sleep, but when woke up spoke quite rationally with open eyes, but on waking in m. knew nothing about this. After 33 m. dreaiJfiil Itching between shoulders, he must rub against the walls. After «5 m. numb pain in joints of lower extremities and great distraction of mind. After \ h- ^-eruption ow inside of r. concha, with imartrng, and, after urinating, buming. Eructation with taste of musk. Inclined to be sick all d. Swelling of hands with shooting pain. After J h. — violent eructation with nausea. Complains of horrible pains, but when asked where, begins to complain still more, but cannot tell where the pains are. Sleep very restless, wakes every \ h. and must throw off bedclothes, she felt too hot, but does not perspire. After 1 h. headache, as if some, thing were driven into occiput, when the pain spread:> co forehead. After a h. very good. ha mou red, cannot say anything when insulted, and yet feels as as if he should Kold. After %\ h. pinching in boweU, so that he call^ out, relieved by crouching together. After 3 h. — headache as if a fine string were drawn several times and tightly over head. Sexual desire excited in a woman, aged 60, who never in all her life had had such a seni^ation. Great desire for coitus, and after indulgence nau.«ieft and vomiting. Palo in nape^ so that !«he could not turn neck. After 4.^ h. — pressure in chest, often faking away hit breath, for 5 successive d. Drawing pain in spine, extending down into hip.joint, and so sc^'ere he Is like to cry out. After 5 h. — tensive pain in abdomen, a« if It would bunt. The menses came 6 d. too soon, with an unaccustomed drawing pain deep in abdomen. Involuntary tossing about hands and feet, in which he has severe pain. After 54 h. very cross, he jumps up wildly in a rage, and does not know what to do for passion, until he smashed a jug near him, when he grew better. After 6 h. — small red pimples, with purulent heads, on upper lids. Forcing downwards in I. side of belly, with constipation. Outwardly cold feeling and inwardly buming feeling on thighs and legs. After 7 h. — pains as if both femora were dislocated, preventing her getting out of bed. Transient shoots in both ankle-joints from within outwards, with dread of walking. After 8 h. — cutting pains in r. forearm, followed by burning. Alternately shivering and hot all d., with prostration, so that he must lie down. After 10 h. pain in r. thigh as if flesh were torn loose. After 12 h. — so forgetful that he did not know where he was; this recurred daily and went off alter 3 d. Pressure on chest, so that he could not lie, he thought he should suffocate and gasped for air. After 13 h. upper eyelids swollen, and pre»Ive sensation in them. After 1 5 h. all n. no sleep, but there were moments when she lost consciousness} when she came out of this state, which was neither sleeping nor waking, she was very exhausted. After 16 h. pain in toes of both feet as if they were squeezed by short boots, when they burnt and hurt. After 17 h. very excited sexual passion in both sexes, with constant tickling. After 33 h., drawing pain from hough to calf. After 24 h. — pressive pain on 1. concha, as though ear were orcs&cd into head. Much rumbling and urging to stool, excrements fint hard, then

\0ftt then normal. Frequent violent aieezing, and every time « few drops. TWitdiing and drawing pains in spine, which are fixed in upper parts oS both thighs and hinder walking. She sits lost in thought, claps her hands together, and xnafces many grimaces, so that it is feared she has lost her senses ; this lasts | h. AfteriS h. tearing.s hooting pain in 1. shoulder, the whole upper pait of arm fecli heavy, tad movement of it is difficult. After jo h.— r. cheek red without heat, 1. cheekpale ind hot Diarrhcea during sleep at n. After 31 h. nausea and v<Mniting of food jotf s%vallowed, followed by violent eructation. After 33 h. on rising, m., much retdiiu, but not vomiting. After 33 h. intolerable cramp pain down tibia, so that she coud scream, with general perspiration. After 34 h. drawing pain frcmi and cervio] vertebra to r. shoulder. After 1 d. — red &ce. Discharge of much wax frain L car. What she eats has nasty taste, except milk. After 3 d.^throbtMngand pecking pain in occiput. Vomiting with constant pressure and distension of stomach. Diarrhaei« with the most violent cutting in abdomen. The stool looks as if he had been eadu sepia. Sexual desire, with 1 involuntary emissions. Shooting in chest with m swollen face, dilated pupils, dry, bright red tongue and violent thirst. Shivering all over body, and yet, on account of heat rising up, cannot rest in the room, better in open air. After 4. d. a pressive pain in forehead indicated by a red spot ; about 3 drop<> of wax came out by r. ear, only at n. N» Hmt mtntmuiL — Ihtxr in head like vertigo, with pressure on crown. Vertigo, nausea, and vomiting all at once. Vertigo and at same time feeling as if he whined round so quickly that he felt die air in his face. Vertigo and dazedness. Vertigo so that ^e fancied the was ftUiiw low down. Vertigo as if she stood very high and was tumbling down. Vertigo ai a intoxicated, he must hold on to something in order not to fall. A vertiginon stupefaction, he thought he could not hear or see, and yet be heard and saw everything.' Vertigo with <<udden fainting. Sudden loss of memory with pressive sensatim ni crown. A kind of complicated pressive and boring head«:he, sometimes all dmn^ head, sometimes behind ears, sometimes in forehead, sometimes In cxown, sometiaKt in occiput. A stupefying headache, making the eyes close. Headache at if the half of the skull were cut through, better in open air. Tearing pain in r. half of head. Tensive pressive headache, with feeling as if something moved in brain. Furious headache. Headache, with nausea and vomiting. Sadden dimncsa of boA eyes, she thought she was going blind. Hardness of hearing. A frightful turiw in r. ear as if a cannon were fired off and some drops of blood came out. Eructation, mth hot saliva in mouth. For several d., whether he had eaten or not, must always vonut at II a.m. Pressure under scrob. cordis, relieved by stooping. Conitipatioo; relieved by coffee. Diarrhoea near^ all n., with great forcing ana pretuvc pam ilk anus. Sexual desire during trituration, thereafter great relaatattoo. - A man, set. 4^ had Ion all sexual power for 4 years after a chill; by triturating mtiak he qvhe recovered his power. Menses very irregular for 3 months. Twitching fton r. shoulder-joint to thumb. Dull pain combined with drawing in ^uteaTmuadOi extending to groins. Tearing pains in all joints of feet, with smsation in nrosciei wt if they were pressed firmly against bones. (Ibid.'j

1. From taking 6tb dilution of Moschus (no menti<Hi made of number of noTa% nor of their sexes or ages, nor yet of the number or rime of doses taken). After 5 m. in navel a pressive sensation and in chest a burning. Afiter ^ h. swollen tensive fiwlh^ and twitching in both hypochondria. After ^ n. lips scale off. Af^ f h. fbrang down in abdomen, as if menses were coming on. After i h. 4 m. involuntary movement of fingers as if picking or counting with fingers. After if h. — vomitmg wi heaviness on chest as if a heavy weight lay there, but breathing free. The chest _ much affected, painful all over, with violent dry cough. After a h.^4 kind of vertigo on moving eyelids, better in open air. Stupefaction with vertigo, must sit down, and still while sitting felt as if he must fall and held on to chair. Headache as if heai^ weight lay on top of head, better when moving in open air. Ashy paJe ftte. In L ear sensation as if a mild wind blew. Throbbing in gastric region. Compresvre pain in houghs as though tendons were too short. Three or four pimples with much Itching in various parts of body. She complains all d. of cold, though the weithcf warm. After %\ h. prostrarion of whole body with pressive pains, cspedal^ fal joints. Itching in back of both ears. After if h. vomiting with bumSng pan in whole of sternum from below upwards. After 3 h. — giddy and unoomfiMlnbk. Vertigo 10 that he could not walk alone, suggers from one side of room to

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Roaring in ears as in syncope. Little relish for food. Violent contnurdve pain tn umbilical region, a deep pit h formed there. Very anxious, she starts up when tbc door is opened and trembles. After 3) hour; sick, after every meal. Itching betwixt toes of both feet, scratched till blood came. After 4 h. noise in both ears lasting a d. Twitching pain in all parts of body, especially at n., it wakes up. Itching in I. upper arm, she mu!it scratch till blood came, then burning came oil. Here and there little papules xvith itching. After 5 h.^transient whirling vertigo. Vertigo on stooping* going off on rising up. Prcssive pain in r. temple. Rustling inl, earaiifa flea were m it. Patutul sens.itian in thigh and lcg,irelicved by movement. He sits doing nothing, then nms about to and fro ; finds fault with everything he sec*. After 6 h. sudden vertigo with dimness before eyes so that he cannot move. After 8 b. — frequent sneciuig with tickling in nose, followed by burning. Here and there or thighs and legs painful points as though he had been beaten. After 9 h. on dorvum of r. foot small papules, which ilch much and bum after being scratched. After 11 h. much burning in urethra, especially when penis is erected. After 11 h. dulne«^ of mind for whole hours, and on coming to himself he complains of shooting in finger.joints. After 15 h.— desire for coitus with tensive pain in penis. Shooting pain, now in neck, now in both shoulders. After 16 h. itching pain in both outer canthi, rubbing does good. After 17 h. stiffness of r. fingers, lasting x d. After 18 h. — menses, which had only ceased 11 d., returned. She is extremely busy, but hardly has she begun to

Rut things in order when everything falls out of her hands from weakness. After ai . pain in hips as if muscles were nipped with pincers. After ai h. eyes dim, with pressive pain in inner canthi. After 23 h. crepitation and disagreeable feeling m r. ear. After 14. h. — headache with drawing in r. ear. Dull pain in whole head, especially e. On rising, m., vomiting, and all he eat» h vomited, all d. Pine stitches with rumbling in abdomen, feeling of anxiety all over body. A kind of pulmonar)' spa<>m, beginning with irritation to cough, gradually increasing and making him desperate, went off in 5 m. Aft«r 18 h. — face verv hot but not red, Vomitmg with tca-dre pain all over chest, relieved by compression. After 31 h, — iioreneu of head to deep in brain. Twitching in r. ann with cramp.pain and goneailecp fingers. After 32 h. pressive pain in chest, now on r., now on 1. side, then through cnest to <.pinr. After 35 h. pressive pain in 1. side of chest as if the pain would pa.s<^ out through the nipple. After 36 n. — pressive -shooting pain in forehead. Pinching pain in abdomen with tenesmus and pressure on bladder, relieved by pressing on it with fist. After 4.2 h. pressive pain in cerebellum. After 1 d.— prestive pain ail over head. Very unwell, must lie in bed all d. Unusual drawing pain on occurrence of menses. Pain in cervical muscles as if they were torn from their ends above and below. Painful sensation all over body with a kind of shivering, but feels warm to the touch. After 3 d. — pressive headache with coldness, as if a cold compress lay on head. Pains in calves ^o that he cannot touch them roughly, they are quite cold on their outer side. In 1 first toe-nails of 1. foot twitching pain as if they were suppurating, he cannot bear an^bing on them and walks barefoot on his heels. After 4 d. — external headache a& if all the hairy scalp were sore, aggravated by touch. On waking, m., bitter taste. Great forcing in abdomen with calTto stool, but nothing comes. Short breathing with shooting in r, «de, better when at rest, but rot quite ceasing. 6ih d., painful emissions without erection. No timt ttattJ. — Headache as if brain would fall out. Rush of blood to, and heaviness of, head. Pressive pain in forehead from between eyebrows down to nose and both malar bones. Small burning pimples on face. Pale face with perspiration. Tension in facial muscles as if they were too short. From I. eye tears flow abundantly with pressure. Pressure with spasmodic pain in scrob. cordis. Feeling of tension in Momachas if he had eaten too much. Very violent stitches in hepatic region, increased by inspiring. Diarrhceic motions j he had 3 or 4 liquid stools mixed with faxes every d. Severe stitches in anus which extend to bladder. Shooting on r. side down to liver. Pressive pain in muscles of upper arm, extending from shoulder-joint to elbow. Pressive pain in hips, must lie down. Pain in r. knee so that he cannot endure bed. Pain m r. biff toe like dislocation, aggravated by movement. Great prostration of whole body With watering of eyes. So tired he cannot move. Sudden loss of senses ; in this state be thinks someone is cutting off his fingers and toes, and he seeks to defend himself with such a rapid and confused torrent of words that one can make no sense out of them. He wuki about but sits down again immediately, lays his hands on his bead,

and compl&ins of Rreat pain without beine able to tell where the pain is. The slightest contact of the air causes a shiver all through bodvimust be jiutto bed, whoe he f^ts warm. Cold feeling, chiefly in qune, with arawii^ pain. Very ovm, inchned to weep. {Ibtd.)

1. SuNDELiN took, m., 3} musk. After a few m. slight excite* ment as from wine, with quick, full, soft pulse, and penpiration. These symptoms lasted 2 h. Breath, perspiration, and urine exhaled, even next d., a strong odour of musk. {Horn's Archw^ 1824, i, 4x7 j in ffltnur.)

2. Mrs. Ch — took 3 gr. Soon pressure in stomach ; after x h. confusion of head, pressure in forehead for i h., recurring after dinner, pulse quick. Took 6 gr. e., pressure in stomach lasting till noon next d. After i h. confusion of head, vertigo^ pressure in forehead till noon next d., dryness of mouth, drowsiness. Again took 6 gr., pressure in stomach, eructation, dryness of oesophaeus. After 2 h. conftision of head, slight vertigo, slight trembling, quickened pulse, loss of appetite^ pressure in frontal region till e., sleepiness, yawning. Next d. confusion of head, pressure in forehead, eructation, till noon. (/i^^ffl«r,iii, 301.)

3. An unmarried lady, of about 40, mentioned to me that she was extremely sensitive to the odour of musk. She would hint if she merely opened a note highly scented with musk. A doctor, who was unaware of this peculiarity, prescribed for her a pill containing i gr. of musk. Soon after taking this she became unconscious, was violently convulsed, and this state lasted nearly a week, with short intervals m consciousness. She said her life was despaired of. (Dudgeon, municated,)