Zizia aurea

van Richard Hughes & Jabez P. DakeA Cyclopaedia of Drug Pathogenesy

Volume IV — Supplement

ZIZIA, Zixia aurea, Koch Smyrnium aureum, L 5 Thapsinm aurcum, Nutt.5 Carum axreum, ‘Bentham and Hooker, “Meadow panm'p., Nat. Ord, Unieligere 1. Provinge—1. Dt. MaRcy, three other men, and one woman, made prosings of Z,,all taking. sod il (5 dr. every 4 h. til effete were produced) save one, ho

Used ist dil. and tinct. Their conjoined symptoms are given in schema form only.*

a. DepresNon of spirits, followed by great exhilaration and desire for conversation ; dreamy imaginative mood ; exhilaration like intoxication (ist dil.) ; irritabilitv, ^vitb lowness of spirits and indifference to everything ; laughing and weeping moods in alternation) sense of exhilaration lasting la h., and then succeeded by great <iepretnon for several d.

t. Seue of tightness round head ; giddiness and swimming ; acute aching in whole 1. side of head, increased by light and noise ; pressure upon top of brain | dull |»uii in occipital region, extending down muscles of neck. Rush of blood to head and face, with feeling ojF fulness and heat ; hcc pale and puffy ; dull pains in jaws ; boring pains in check.bones. Eyes sensitive to light ; sharp pain in r. orbit, in> creasing by moving eyeball, by stooping and stepping ; shooting pains through both orbits ; eyes watery ; smarting of lids ; lids gummed in m. by yellowish mucopurulent secretion; stye on r. lid. Irritation of Schneiderian membrane, with discharge of mucus and sneezing ; obstruction and soreness of r. nostril, which is paintul to touch ; burning and smarting sensation in nostrils and eyes.

c. Inflammation of mucous membrane of pharynx ; slight redness of tonsils and palate, with soreness of throat; increased secretion of mucus in throat. Loss of appetite ; bitter taste ; craving for acids and stimulants ; thirst ; tongue covered with vrniti^ fur; redness of tongue, with unusual sensitiveness to cold or warm drinks. Manaea; add and bilious vomiting} stomach sensitive to touch, — pressure causing nausea and faintness.

J, Some sexual excitement in male provers ; in the woman leucorrhoea, at first bland, then, after one day only of (profuse) catamenia, acrid.

t. Roughness of upper larynx when inspiring or coughing; trachea sensitive to touch ; tight cough, caused by deep inspiration, and excited by dryness of larynx { raw smarting sensation in larynx from coughing ; short dry cough, excited by tickling in throat pit. Dry cough, with pleuritic stitches in r. side, much increased by coughing or deep breatning, with feverbhness and sense of suffocation; bruised feeling in muscles of chest, pressure excites pain in intercostal muscles ; sharp pains extending from front and sides of chest to both scapulx ; respiration accelerated and oppressed ; dyspncea, with inability to retain recumbent posture.

y. Dull aching pains under r. scapula ; smarting, burning pain in small of back ; dull pains in loins, increased by movement ; dragging sensation in both hips { -unusually tired feeling in legs after slightest muscular exertion ; great desire to move about, with apparent increase of strength, bat slight exercise causes ftitigue. Lameness of muscles of both arms, from shoulders to elbows ; prickling sensation, with slightly diminished sensibility, in r. arm.

g. Drowsiness, with sense of lassitude and fatigue; after exhilaration of all faculties strong desire to sleep ; sleep disturbed by unpleasant dreams ; spasmodic twitching during sleep ; talking during sleep.

A. Pale and puffy appearance of whole body, with sensitiveness of surface ; itching pimples on forehead, wrists, and legs.

t. Chilliness and heat alternating, with faintness, nausea, pain in r. temple, redness of eyeballs, dry and red tongue, and thirst for cold water ; hot flushes in race and head, followed by perspiration; chilliness, accompanied with spasmodic twitchings of muscles of face and upper extremities, followed by fever, flushed cheeks, hot head, visible pulsations ot carotid and temporal arteries, coldness of hands and feet, drowsiness, and irritability, (ff. Am. Jeitrn. qfHom., iv, 54.)

a. A young lady, of 23, inhaled 4 times a day for 6 d., 10 m. at a time, a sol. of 4 dr. of 3rd dil. in 4 tablespoonfiils of water. She vnis somewhat delicate ; had suffered in years past ftota dyspepsia and asthma and for the last two years from occasional paroxysms of nervous and sick headache, pains between shoulder-blades, and leucorrhoea. A previous proving of 4 d. had only elicited such symptoms as the above, and she hesitated to set them down to the medicine ; but tiiey were all

• Some of these symptoms are suspiciously like those developed in Case 1. 1, and can hardly be taken as confirmations of hen — themselves not free ftwn dubiety.— Eos.

reproduced with increased severity on the present occasion, and as her health when ‘commencing it was in every Fespect good, and there was no other appreciable cause or reason to expect them, they may filly be asigned, in part at least to the tmedicine, They are grouped a2 fllowss-—

“a. Swimming in head and drowsines, slight (on ast d, of both provings). On 1st dc indolence and contentment, which then gave place to nervous inritablty and depresion of sprit these increasing during proving. and culminating on 6th & in. Paroaysm of sellsasattaction, with weeping. Hebaviour throughout was quiet, Irith much apparent suffering aad sadness” SKep wa sound until 6th ny when snas prevented by pins,

harp hetche over eye began aightly on and d, and increased il Sh, In its fall development it wat grevouy, with nauee, inclination to billows vomiting, need to lie sill n'a darkened and quiet room light, nole, and jar aggravated, (te aired trom the onfinary type ‘only in pain being fied on r. side tstead of {hitting ; and in exacerbations occurring in cr instead i'm) Te abated 24 be Bfier ditontinulng inhalation, leaving much senstivenes, bitter taste in mouth, and fusceptible and fecble slomach, for several longer. "When at ite worst, pain descended behind. ear into neck i Heft lips parched as from fever, and’ biter bid en meth” Bees ht fchea nana wth hap ating ain by the jar of coughing on the gth Face exhibits throughout a pale pully appear ce sory Sad on nds thee wa pant tegen or oer oebone

¢, From the frit inhalation, thre was nasa eatarrh with sneezing and coughing, and discharge of thick mucus,r. nostril ooly being aceted, but the sore and tender to touch, With this was oberved difused injection of velum palati, with ordinary Seve of ata soe tet, Conjuncvalsrbranet exhibited «mar Giffosed injection, andr, was seat of paiaful and quite unwonted symptoms 2 3 developed on mide of upper id, and gave so. much pain on th dy that he took. carbo animals as antidote To 34 h, the stye had departed, bu F,eye continued to bur, smart, and weep j and even up to sth after sopping inhalations both eyes wrete very weak and paoful if wed atm.

A group of pleuritc symptoms were regularly developed from the fst inhalations, reached thet'acme on the 7th dy and were sill very troublesome on the roth (wha this record was made), “Phere was shor, dry, bard cough, with stitching pain Sn side from beneath 6th nib to's in, below xiphotd carlage, over later, ad at eireumscribed spots on each side in below, there was painful tenderness to touch from ath to 9th she could not draw a fullbreath without severe pain eatehing het about", 6th i in fron, and pieseing through to back,

“ier each inhalation she felt slimoxt sted for about r0 m, though iahalation itself was made easily and’ frely.” The annoyance augmentsd as the proving procecded, and remained constant though less severe fora week alter discontinuing Feo" Tes seat seemed beneath sternum, on a line with axl ‘There was no audible vrhcering, but sensations in chest were the same as during her lormer 8s of asthma, (These had ceased abruptly six years previously, save that alice about four years she Sad one attack of but j hs duration.)

°f, Hert accustomed back-ache began on and dy increased in severity til 7th, and wad sil felon 1gth d, ts seat ie at posterior lateral margins of scapula} pains Srv aching, smarting, and stinging, and! when worst there is alo aching in small of ihack, They ate geteraly worse on 1 side but during inbalations i was ther. side that chiely sufeed, |. side resuming ite predominance ‘on thelr discontinuance. (These pais are ordinary with her when her vitality depressed from any ease but she had no such reawon for expecting them on commencing the present provi)

‘ge Lecortheea commenced on and'd, and continued til 7th, scanty aad acrid at fst, then bland and copious, "(This was observed during both provings) | Cataimenia appeared in due cme, but ceased alter th, which i altogether unusual

"i. Appetite diminished a the drug lines beeame more pronounced y thirst was increased tongue was broad, furred in middle, and reddened at tip and sides. (16d.)

"Th. Poisoning vs. If a smal piece of the root be chewed, oF a few dr. of tne. be applied ta tongue i produces sense of faintness and exhaustion, On one occasion,

‘They became matutinal again when the inhalatons were left of

after filtering tome of the tinct., eyelids became somewhat inflamed, with smarting, itching, and prickling pains, — r. more than I. On bathing face with a lotion of a few dr. of tinct. to Oj of water, a creeping, smarting, and itching sensation was felt in cheeks and lips. {IbU.)

s. A gentleman chewed a piece of root for experiment, and was immediately seized with nausea, vomiting, spasms, general convulsions, and fainting fits, which terminated in death after 3 h. {Ibid.)

  1. A young lady ate a large root by mistake. Soon after she was seized with violent vomiting, spasms, swoonings and convulsions. The speedy discharge of the poison by vomiting enabled her to resist the toxic influence and regain her usiuil health in a few d. {Ibid.)

  2. The odour of the root has been known to produce such ah effect on the system as to confine the subjects of its influence to bed for days. In these instances nausea, fiuntness and las!>itude were the symptoms observed. (Ibid.)

III. Obttrvations in animals. — i. An ox, after having eaten the top of the plant early in the spring, vomited and staggered about as if intoxicated. It continued reeling and staggering for 3 d., and then recovered. (Ibid.)

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