Comocladia dentata

di Richard Hughes & Jabez P. DakeA Cyclopaedia of Drug Pathogenesy

Volume II — Main text

COMOCLADIA . Comoladia dentata, Jacq. Bastard Brazil-wood ; Guao. Nat. Ord., Anacardiacea. I. Provings.- 1. a. Dr. J. S. HOUARD took, Nov. 18th, 1854, a dr. oftinct. m. and e., and same on m. of 19th. Nothing noticed till 8 p.m., when severe tickling itching attacked scrotum, 1. thigh, arms, and r. leg in succession, shifting rapidly fromplace to place, worse inwarmth and at rest. At bedtime and next m. took I dr.; no symptoms till after sundown, when similar itching set in, and continued through e. 21st.-In m., 4dr. Similar itching at various times, and in e. eyes felt sore, with some lachrymation. 22nd.-On waking, face around eyes felt swollen, and r. eyeball very sore, worse on movement. At 4 p.m., eye still very painful, feeling larger andmore prominent than 1.; eyes look dull and glassy, vessels congested, lids redand swollen, andjust below lids face is much puffed. While in open air during d. profuse lachrymation. 23rd.-Eyes same ; in e. severe pain at intervals from back ofeyes to occiput, with pressureon balls from above, seeming to roll them downwards and outwards. Eyes worse on using or moving head, and on exposure to light. 24th. No change in eyes; in e. took belladonna. 25th.-Soreness greatly diminished, but swelling took 2 or 3 d. to subside. b. Feb. 4th, 1855, took 3 dr. in m. fasting. At 4.30 p.m., sense for 30 m. as it all r. molars were loose ; after which steady aching and soreness in one of them, carious but painless hitherto,lasting till bedtime, relievedbyheat. 5th.-At 10a.m., 4dr. In e. soreness and stitching in eyeballs. 6th-8th.-During these d. stitches, itching, and crampy sensations in various places, and (for h.) similar pain in another (sound) r. molar. From 10th to 13th, eruption of small pimples in various parts ofbody, with much itching. On 15th and 16th, several recurrences of acute short-lasting pain in various places, especially in mamme. (Philad. Journ. of Hom., iv, 73.) 2. Miss J-, æt. 18. On Feb. 5th, 1855, at 10 a.m., took 4 dr. of 1, dil. From 12-3 , aching in a r. upper molar, with twitching and sense of elongation, relieved byheat; after this, head and eyes felt heavy and large, and eyes as if pressed down fromabove, heat aggravates, also stooping, open air relieves; eyes water profusely from exposure to heat or light, and felt painful up till bedtime. 6th.-Head still heavy. At ro a.m., 3 dr. Atnoon, nausea for 1 h., after which intermittent aching in all teeth for h., and soreness in eyeballs. 7th.-Much epigastric distension, causing dyspnea, lasting from 1 p.m. till 3 p.m. next d. 8th.-At 2.30 p.m., heavy aching drawing in 1. axilla, through to shoulder, with sensation as if shoulder would be drawn towards neck, forth. 9th.-Painful drawing in r. palm for 3 h., followed by (for h.) sharp stitches and then smarting in popliteal region. 12th.-Violent pain from back ofr. eye to occiput, with great soreness and sense of enlargement of ball and profuse lachrymation, from 10 to 11 p.m. Eye felt quite sorenext m. Also itching of nose below bridge, within and without, for both these d., worse in warm room,better in cool air. 13th.-For 2 h. a.m. dull aching on extensor surface of 1. forearm and hand. (Ibid.)

  1. Mr. G-, æt. 21, took on e. ofFeb. 5th and 6th 15 pellets of Ist dil. About 4.30 p.m. on 7th, aching soreness in eyeballs, increasing in severity during e., sometimes making him very dizzy, and continuing till he went to sleep about 10 ; aggravated by looking at lighted candle and by motion, stooping or moving head causing flow of tears. 8th.-At 7.30 a.m. , drawing or cramp-like pain in r. axilla, lasting h. (Ibid.) 4. Man, æt. 22, Nov. 18th, 1854, after breakfast took 2 dr. of tinct. At 10 a.m., tingling itching on lower sternum, and shortly after on whole chest; itching of same character on ankle, and (later) on calves and abdomen. At 10 p.m. , 2 dr., and same at 9 next m. Found red, hard pimple outside of sacrum, painful when touched. Aboutnoon, intense itching on scrotum and penis, also felt internally ; at intervals during d., tingling itching at various spots on lower limbs ; at 6 p.m., numb, tensive pain of forearm, and rheumatic stiffness of shoulders and elbow-joints, lasting for 3 h.; at 10 p.m., similar pains on inner thigh from scrotum to condyle; continued tingling itching of scrotum during n. 20th.-3 dr. at 9 a.m. At 10 violent burning tingling itching of lower limbs. (Ibid.)* II. Poisonings.-1 . Mr. Отто, in cutting off some shoots of the guao, stained his hands with the dark brownish-green sap. About noon he experienced painful burning on face and arms, and particularly about eyes, which became greater towards e. Sleep was tolerably placid, but on waking next m., he found face dreadfully swollen ; eyesprotruding, onlya faint glimmer oflight perceptible with the 1.; and a tormenting itching and burning came all over body. As this and the swelling of face subsided, ageneral red colour ofwhole surface supervened, with burning sensation, and after this his skin looked like that of a mulatto. (Phil. Fourn. ofHom., loc. cit.)

Volume II — Appendix

Comocladia.-P. 370, title, for " Comoladia " read " Comocladia." After I. 4, add- 5. a. May 12th, 1875, took 10 dr. of tinct. at 10.30 a.m., and same at 12.30. Appetite for dinner, at 1 p.m., less than usual. At 3 p.m., while reading, had aching in lower incisors passing to r. cuspid and bicuspid teeth, lasting 5 m. Walking in open air at 3.30 p.m., had acrid, rancid eructation. Took 20 dr. 4.30 p.m.; at 5.30, at rest, had soreness in l. lung. b. Took 10 dr. June 17th, 1875 , at 6.30 a.m. At 10, while resting, had sense of fulness in face over superior maxilla, and sensation as of pimple over r. antrum. Itching inner side of 1. thigh, then above r. eye and then on scalp. Eructation of air tasting ofdrug. Itching at inner border of 1. gastrocnemius, relieved by rubbing. Tingling itching on r. side of upper lip, then crawling itching in r. malar region, then itching moving downwards from r. commissure of mouth, then itching on palmar side of r. carpus, moving toward palm of hand, then itching at angle of lower jaw, r. side. At 10.55, itching of eyebrow. At 11.40, biting, corrosive itching on r. fore. arm, over belly ofpalmaris longus ; itching on r. side of face near angle of jaw, on posterior aspect of r. forearm, on dorsal aspect of Ist phalanx of r. index finger. Cheerfulcondition ofmind during forenoon. No appetite for dinner at 12.30. 18th.- Slept soundly, arose refreshed and cheerful. Took 10 dr. 30 m. before breakfast at 6.10. Soon after tense feeling in abdomen as if full offlatus. After walking in open air, while sitting, had bubbling in hypogastric region,also (later) pain there as from 8.30, sudden lameness and loss ofstrength in 1. ankle. While flatus. While walking, 8.30 resting, 10 a.m. , corrosive burning on side oflower lip. At 3.30 p.m., after a walk, sitting with r. leg extended on table,crampy lameness just above instep,relieved by walking. Immediately after, while sitting, drawing crampy sensation in hollow of r. foot, passing up to outer ankle and along border ofgastrocnemius to knee, relievedby walking, returning while sitting, feet resting on floor, passing slowly upward from outer ankle to knee, then intibia where it became a numb aching, as iffoot would cramp, relieved by continued motion. 19th.-Took 25 dr. at 6.30 a.m. At 9.15 sensation as of scabby eruption on median line, lower lip, close to vermilion border. At rest at 2.30 p.m., had lame, aching pain in r. upper arm, and, soon after, lame aching pain in r. knee and sharp pain passing through r. shoulder to scapula. At 3.20, intermittent, pressing outward pain at 1. sacro-iliac articulation, sensitive to pressure, relieved bywalking, with lameness and soreness. Pain along outer side ofr. thigh. Sense of expansion in cœsophagus, as of air ascending slowly from stomach. At 3.50, drawing pain in r. knee extending into anterior muscles ofthigh ; then pain under lower part of 1. scapula; sense ofdrawing in r. anterior wall ofchest; aching in lower incisors that leaves them very sensitive to pressure from upper teeth. During afternoon had itching on different parts ofthe body. (Further record lost.) 23rd.-Took 40 dr. at 4.10 p.m. While at rest, numb, drawing sensation in instep, extending to knee, followed by sense as of warm air, like an aura, ascending halfway toknee. The numb. ness and drawing concentrate at instep, where it remains a short time,and again the

aura ascends slowly to the knee ; the tibia and fibula ache ; sense of increased temperature and fulness in leg. The numb drawing moved over the dorsum of the foot to the toes where it terminates in a prickling. Relieved by motion, returns when it ceases. c. Jan. 22nd, 1876, 5.30 p.m., took 3 dr., and at 11 p.m. same. At 12.30 next m. had crampy aching in r. instep, relieved by motion. Intermittent pressing outward pain in r. knee, relieved by motion. At 7.30 a.m. took 3 dr. and 3 at 1 p.m. At 3.20 pulsating pain in head of r. tibia, relieved by motion. At 4.45 p.m. took 4 dr. At 5.30, while sitting, pulsating pain in head of r. tibia, sensitive to pressure . Aching in r. upper molar tooth and gum, worse by cold. At 9.50 p.m. took 4 dr., retired at 11. 11.30 p.m., while lying on r. side, aching in r. temple, followed by aching and sense of fulness in r. side of face. Soon after, aching in ankle and r. forearm, deep, pulsating pain in r. gluteal region, near tuber ischii. 24th.-12 m., took 8 dr. 12.30 p.m., dined. 1 p.m., immediately after dinner, aching in body of last r. lower molar. Heat and fulness in interior of r. ear, at same time short, cutting pain in gum of first 1. lower molar. 2.20 p.m. , took 8 dr. 4.15 p.m., while at rest, drawing sensation and aching, commencing suddenly in r. axilla, moving down inner side of arm to elbow. 4.30 p.m., pulsating pain in interosseous tissue at palmar aspect of 1. forearm, near wrist, extending to little finger, when it becomes drawing, crampypain; then drawing sensation extending up forearm from wrist. 4.50 p.m., pulsating, deep pain in posterior and upper part of r. thigh. 5 p.m., pulsating pain in r. gluteal region near tuberosity of ischium; sensitive to pressure. 6.30 p.m., pulsating pain near upper extremity and outer side of r. fibula. Immediately after, pulsating pain in r. thigh. Sleep was dreamy and refreshing, more like a clairvoyant state. After midnight dreamed of birds singing, which awoke me and caused me to listen with intense interest, but stillness and darkness reigned supreme. d. Feb. 6th, 1876, 3 p.m., took 10 dr., and same at 10.55 p.m. on retiring. Soon after, lying on 1. side, drawing sensation and aching in upper part of r. forearm, pulsating deep pain in r. gluteal region, just above tuber ischii, seeming to be in periosteum ; sharp pain just above crest of r. ilium, after which pain in r. gluteal region returned, then sharp pain just above crest of 1. ilium, drawing and aching in r. foot, drawing and aching in anterior muscles of r. forearm, pulsating,deep painin r. gluteal region, sensitive to pressure, drawing and aching in anterior muscles of 1. forearm. Drawing in outer side of 1. foot extending to plantar aspect, as if foot would cramp, drawing and aching in 1. leg,not relieved bymotion. Same aching and sense of drawing in r. forearm near elbow; return of pain near r. tuber ischii, aching in r. leg, pulsating, deep pain in r. thigh, at inner border of sartorius. Itching on extremities and face. Sleep last n. was light and dreamy; after midnight dreamed I entered a beautiful garden, from which I passed into low woodland, in eastern border of which was a sluggish, broad, shallow stream of water, to cross which dryshod required some exercise of mind. This m. arose refreshed, light. hearted, and cheery. 7th, 7.4 a.m., took 10 dr. 10 a.m. , while standing before hot stove, return of pain near r. tuber ischii. 12 m. , aching in r. leg. 3.30 p.m., took 10 dr. 3.40, pain in r. side of abdomen, moving downwards, following course of rectus muscle. Pain in r. anterior wall of chest near axilla. Pulsating pain at 1. pubic bone, continuing several h., generally relieved by walking, sometimes felt while walking; pain seems to be in periosteum; sensitiveness on pressure. Aching and sense of drawing in outer hamstring of r. leg. 4.12, pain above 1. eyebrow. 4.26, return of aching and drawing in hamstring. 5, pulsating, raw pain near sternal border of1. mamma, seeming to be in cartilage of 5th rib. 6, drawing sensa. tion in r. big toe, as if toe would cramp. Drawing in muscles of upper r. arm, then indorsum of r. foot, then inplantar region of same, shifting from place to place as rapidly as symptoms can be written. Aching in r. temple and r. orbital bones. 8th, 1.30 p.m. , while writing, lancing pain suddenly attacks r. metacarpus, terminating in lame aching and drawing sensation in metacarpal region of thumb and index finger; drawing sensation in r. anterior wall of chest and r. arm, passing down arm to elbow. 2.18, pulsating pain at 1. sacro-iliac articulation. 2.50, numb aching passing down outer side of r. leg to foot, aching and sense of drawing in outer hamstring. 3.5, pulsating pain in sacro-iliac articulation, leaving lameness feltwhenwalking. 9th, 10 a.m., transient drawing pain passing through r. carpus, leaving wrist lame on motion. 2.35 p.m., sharp pain passing down r. temporal ridge and external angular process. Immediately after, sharp pain at r. supra-orbital ridge

close to supra-orbital notch; sharp, broad pain passing from lower angle ofr. scapula to locality of serrations of the serratus magnus; pulsating pain at posterior aspect of coccyx. 9.25, after a walk in open air, and while in room reading, sharp pain suddenly pierces palmar aspect of 1. carpus, traversing dorsum of 1st and 2nd fingers, becoming a drawing pain in its progress to metacarpo-phalangeal articulations of these fingers, then involving all the metacarpo-phalangeal articulations of the hands, drawing fingers closer together and thumb towards palm of hand. Whole hand is numb, looks and feels swollen, its temperature is increased. Continued motion relieved drawing, but not numbness, which continued 15 m. 9.32, during numbness of1. hand, sharp painin dorsum of 1st phalanx of r. index finger, shooting to articulations of its 1st and 2nd phalanx. 10th, 2.35 p.m., while writing, pain in upper and posterior part of l. thigh. 2.45, sharp, sticking pain inr. elbow. 3.33, drawing pain indorsal aspect of metacarpal region ofr. thumb. e. Feb. 15th, at 11.45 a.m., put 2 oz. of cold water and to dr. of Ist dec. , into a Fullgraf's inhaler and inhaled for 20 m. 2.5 p.m., eructation of sour, acrid water. 2.45, stinging itching on r. scapula. 3, hiccoughed several times ; immediately after gaped several times. 3.30, inhaled again for 20m. 3.40, while inhaling aching in r. forearm, commencing in belly offlexor carpi radialis, extending through arm. Arm is sensitive to pressure. 3.45, sense ofdrawing in r. forearm, extending tometacarpus. 3.47, crampy sensation increasing to aching in Ist phalanges of r. hand, continuing 10 m., relieved by motion of fingers. 4.10, pulsating painin neck of r. femur, seeming to be in capsular ligament, ceasing while walking, returning when at rest. 4.15, stinging in small spot on dorsum of ist phalanx ofr. and finger. 5, aching in r. anterior wall of chest, extending through to r. scapula. 10.30, inhaled 20 m. Aching at base of r. antrum of Highmore, then at base of 1. antrum. 11, retired; soon after while lying on 1. side, aching at lower third of sternum, continuing several m. Immediately after, expansive, intense distress in epigastric region, like heartburn, extending through to posterior border of 1. scapula, continuing h. , ameliorated by lying on r. side. 16th.-At n. while in bed, pulsating pain in neck of r. femur. This pain felt several times during d. 17th, 10.10a.m. After walk in open air, soon after entering my office intense acrid eructation, producing momentary strangulation. 10.50, while walking in open air, sticking pain from without inwards in regionofcartilages of6th and 7th ribs. 1 p.m., pulsating, deep pain in neck of r. femur. This pain seems in capsular ligament at inner border of ilio-femoral liga. ment, and continues 10 h., relieved by walking. 4 p.m., aching in r. temporal bone, commencing in temporal ridge and extending to occiput; whole base of head is very painful on moving head, also sterno-mastoideus and trapezius muscles. 4.36, thread-like pain in r. foot below outer ankle terminating in anaching. 9.30, aching in l. forearm. 18th, 3.25 p.m., drawing, crampy sensation in r. anterior of chest and axilla, extending down arm to fingers and terminating in jerking of little finger. 3.45, drawing, crampy sensation inmuscles of r. upper arm. After short interval, similar sensation in r. elbow. 19th, 2.30 p.m., inhaled 20 m. While inhaling, drawing, crampy sensation at outer border of r. mammary gland, extending to axilla and arm. 5, inhaled 20 m. 5.5 p.m., return ofpain in neck ofr. femur, continuing several h. Meibomian glands of upper lid ofr. eye are inflamed. 10.25, inhaled 20 m.

While inhaling aching in os frontis and orbital bones. While in bed, sore aching in anterior wall of chest, in muscles of r. arm, and in coccyx. Sticking pain inmetatarsaljoint of big toe, at plantar aspect. 20th.-During d. aching in anterior wall of chest. 2.30 p.m., inhaled 20 m. 3.15, intense aching at posterior aspect of middle of sternum. Inflammation of Meibomian glands continues. 4.30, while at rest inwarm room, transient painpassing upwards over inner ankle of 1. foot, followed by severe flatulent pains in hypogastrium and emission of flatulence, followed by pain in abdomen. 6, severe flatulent pain inabdomen, preceding and during a diarrhœic stool, followed by feeling ofweakness and perspiration on face and neck. 7.15, after walk in open air and being seated in warm room, itching in r. side of trachea, producing dry, hacking cough. Soon after, itching in 1. side of trachea, causing dry, hacking cough. Drawing sensation in upper r. arm, followed by aching inl. side at floating ribs. 9.45, crampy aching below r. scapula. Crampy aching in r. wrist. 9.50, lame aching at inner side ofr. thigh, just above knee,followed by wiry or thread-like pain in r. instep. Immediatelyafter, sore aching at r. scapula. 10.55, took 8 dr. 21st.-During forenoon, aching in both sides and upper arms; r. side

worse. 4.35 p.m., took 12 dr. Several times during afternoon sense of weakness, with heat and perspiration on face and neck. Dull aching in forehead, and on moving head a sense offulness, rigidity, and lameness of muscles of neck. 10, pain in epigastrium as of flatus; at same time aching indorsal region. Wandering pain in r. side of abdomen; aching in ramus of r. maxilla. 23rd, 9 p.m., intermittent aching in r. tibia. Inflammation of Meibomian glands has subsided. 24th, 4.30 p.m., severe aching at internal condyle of r. arm after a walk in open air and while standing in open air, continuing 5 m. At same time and while arm is resting on a support, sense ofdrawing at inner side of 1. upper arm. 5.10 p.m. , after light exercise in open air and while in room, aching in 1. maxillary articulation, leaving sense of fulness; immediately after, aching in r. maxillary articulation, terminating in sharp pain. 5.22, after short walk in open air, having entered a warm room, aching in r. maxillary articulation and whole of r. side of head. 5.30, while at rest in warm room, sore aching of gum of r. upper molar teeth. 7, while riding on horseback, drawing sensation in muscles of r. upper arm. 9.20, while seated in a warm room, immediatelyafter supper, intense crampy aching in 1. knee, continuing 8 m.; not relieved by motion. 26th, 5.44 p.m., while at rest in a warm room, atmosphere loadedwith moisture, south wind,drawing, crampy sensation at dorsum ofr. foot, in region of external cuneiform bone, spreading outward and over the cuboid and forward over metatarsal bone of little toe,moving upward to region of anterior liga. ment, where drawing, crampy sensation ceases and becomes a bruised aching, extending to external malleolus. Sometimes it extends up tibia and fibula, producing feeling of fulness in these bones. When walking there is lameness. 5.57, drawing, crampysensationin l.carpus,then in anterior muscles of r. upper arm. 27th, 3 p.m., while at rest in house, return of aching in r. ankle. (J. HYDE, M.D., American Observer, iii, N.S., 593.)

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