Jatropha curcas

Volume IV — Appendix

JATROPHA.

Jdlnpha atrcat, L. Physicnut. Nat. Ord., EuphorbUuea.

I. Prtmngs. — i. a. Lbmbkb took Dec. si, 6.30 a.in., i dr. i*dil. Immediately continued rumbling in all parts of belly, which is distended. Pain deep in umbiliou region. Chilly feeling deep in lumbar vertebrae, and at 6.45 a.m. call to stool, a couple of h. earlier than usual. 7.45 a.m., great chilliness through all limbs, extending to scalp, violent tearing pain deep in umbilical region aggravated by pressure. &tm of extremities cold, nails bluish, chill over back, urgent call to stool ; tension in inguinal region ; whilst walking, twice like a blow in muscles ot sacral region. 8 jtjn.. loose ttool preceded and followed by rumbling, sometimes a noise as though a iMttle were emptied. 1 1 ajn., pain in umbilical region ; copious and frequemt <i&ehuge of urine, asnd. — Stool delayed. s3rd.— 7 a.m., 5 dx. titvcX. ^tu&vi^ '»A contractive pun in rztious parts of extremities, espedaVly Ynvst,to»,%cA c^'««%\

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shooting in calves ; nausea ; severe drawing pain in stomach ; dull pain niiog im stomach to oesophagus j great coldness deep in spine and wearine« of upper mb] stiffness in nape. Deep in chest behind sternum severe shooting pain» troia lbs* downwards. 8 a.m., rumbling and empty eructation; stitches in anus; drjun* fauce!^; discharge of flatus. When sitting bruised feeling in icneev ; paininumbi[i region 5 frequent urination. Normal stool at 9 a.m., constant irritation in to navicularis peni», like a tickling, with frequent urination ; clear mucus exudes «lo«l from urethra when walking and sitting. i4.th. — Stool harrier than usual, ijtli.— a.m., 10 dr., scrapy taste, 9.30 a.m., persistent pain in stomach 5 chllline« cm back extending to upper arms even in vvann room. Hands cold, blue nails. 9 a.m., constant urging to urinate. Repeated quivering of I. upper eyelid. Abdonn distended and soft, stomach pains aggravated by pressure; pulse 73. 11.30 p. stitches in rectum, formication under skin of sacrum. 26th. — 7.4J *.m., w 4 immediately, heat in stomach. Transient pains in both hypochondrii and parts of extremities. Heart's beats suddenly perceptible to hand and in chest, ing in ears ; rumbling in belly and jerking pains deep in abdomen, which is ' and soft. Contractive pains in 1. masseter muscle ; much rumbling in belly. 1. a.m., bruised pain in knees. Jerking pains in region of stomach ; drawing pains various parts of extremities under skin ; pressive pains in calves and r. muscle. Frequent shivering in lumbar region ; transient pains in lumbar m chest, and shoulder.joints ; frequent call to urinate. Persistent pain in mac drawing in air of room, which feels cold though it is warm. Persistent diyuen! fauces. The stool at 9 a.m. unusually hard. Repeated quivering in I. eyelid. «» a,m., frequent rumbling in belly. All d, and next n. urine scanty, dark brown, clttr,

b, Jan. 1st, 7 a.m., 3 gr. i* trit. of seeds. Taste oily, slightly soapy. W: in stomach, some rumbling, discharge of flatus. 7.1 j a.in,, slight pressive stomach ; great coldness in back extending to upper arms ; persistent obtuse _ in stomach extending upwards into oesophagus ; transient pressure in dor»al' and 1. upper arm, 8 a.m., empty eructation ; quivering of 1, eyelid ; bruixd . shoulder-joints; frequent flow of thin saliva ; on outside of r, calf persistent prrat drawing pain. In I. calf and dorsum of I, foot feeling of stiffness and pressing^ bruised pain in muscles of arms ; occasional pressure in stomach. 9 a.m., persisM cutting pain in stomach and whole abdomen, increased by prepare, abdomen st much rumbling; abdomen then very distended, tense, tympanitic. 9.30,1 sto«l ; the abdominal pain lasts ) h., then goes off, much flatus discharged; gn chilliness with cold hands and blue nails, ti, noon, much rumbling in belly a sometimes pressure in stomach. — ind, 7 a.m., 8 gr. Chilliness in spine ; wirmth stomach. 7.15 a.m., pain in stomach going by jerks into navel and oKoptufl Shooting and pressing in 1. sole and calf. Pressure deep in chest behind {ternui Rumbling and flatas. Shooting and jerking in 1. sole whilst sitting. A jerkiogpi in 1. hypochondrium and to lumbar muscles, 7.30 a.m., stiffness in I, calf; bruii and stiff feeling in shoulders ; abdomen tympanitic ; urging to urinate ; erucution air, 8 a.m., prickling in dorsum of 1. hand, pressure in upper arms and r. calf «ll sitting ; a soft stool, followed by persistent pain in umbilical region, abdomcQ tyt panitic i spasm in stomach on bending forwards. Occasional coldness thiw^ back. 8, JO a.m,, abdomen has become soft and sunken without discharge of flifl Frequent micturition, urine bright yellow, urinary tenesmus after having ufatiU Abcfominal pain till 11 a.m., and stitches in rectum. £., much borbor^'gntut u bottles were being emptied. The stool which occurred at 10 p.m. »v.rs t'hiD.aHii borborygmus continued after it had passed. — 3rd. Abdomen soft and si 4.th, 6,45 a.m., *6 gr. 7 a.m., pressing in forehead, heaviness of head } p drawing in I, big toe and foot dorsum, internal twitching in r, toes. Puinfl feeling in lower limbs, especially knees. Internal pressing in flexor forearm, 7,30 a,m., pulse 70 (75 is normal). Bright and dark '.pot- Eructation of air. Painful pressing in outer muscles of legs, and inward fur Drawing in muscles of 1, shoulder. Bruised feeling, worse when mi walking about room. Pulsation in 1. calf, stiffness of both calves. When stiflFand unsteady in limbs. Borborygmus, like fluid running to and fro ia flow of saliva; hot feeling from stomach to vertebrw. Abdomen distended, w and flo»v of saliva. 8 a.m., head confused, vertigo as if he turned round walking, pain in calves and drawing in legs internally; heat over back. In'

Itching in fingers. Persistent urging to urinate. Obtuse pressure in stomach; pulse 66. Painful stiffness in lumbar, nuchal, and frontal muscles. Pressing in shoulder.joint. Unsteady gait, body inclined to go to 1. Pain in muscles, worst when utting. Noise in bowels like fluid running to and fro. After the slightest exertion painful feeling of exhaustion in the muscles, even when writing and standing j pulse 70. Urine bright yellow, frothy. 8.30 a.m., urging continues after urinating, rersistent dull pain deep in umbilical region. Pressing in I. masticating muscles. Abdomen tympanitic. Painful pressure in r. pectoral muscles and stomach. Re> peated chilliness in back. 9 a.m., normal stool, pain in abdomen continues. Urging to urinate. 9.30 a.m., internal twitching and pressing in toes and 1, calf towards intenial ankle and on inner aspect of tibia. 10 a.ro., painful pressing in lumbar, dorsal, and pectoral muscles. Pain in belly and call to stool, with anxious feeling in scrob. cordis; heels very sensitive when treading. For i h. chilliness and cold feeling through abdomen ; palms moist and cold.

e. Jan. 6tn, 6.5 a.m., took the whole outer shell of a seed weighing 6 gr. 6.30 a.m., stitches in I. big toe and rectum. Shooting in throat when swallowing. Heat in sinciput, and boring in ears. Pressing and stiffness in 1. calf. Pulse 75, irregular. Pressive pain on dorsum of r. foot, posterior aspect of I. upper arm, and flexor surface of 1. forearm. Urging to urinate. 7 a.m., pressure in occiput, nausea, heat in head and face, confusion, shivering over back. Respiration laboured. Borborygmus ; pupils contracted ; heat in stomach. Sudden violent stitch from ensiform cartilage over I. costal cartilages, affectiiig breath. Urging to stool. 7.30 a.m., noise of a fluid in bowels, abdomen soft. Pressive pain in shoulder and dorsal muscles, in knees and calves, with feeling of exhaustion. Head confused, heavy. Persistent chill over back. Constant call to stool and noise of fluid in abdomen. Persi^ent stitches deep in I. ear. Constant urging to urinate. 8.45 a.m., eructation of air. When coughing and blowing nose, feeling of stretching and protrusion in 1. inguinal ring, making him bend thigh up towards abdomen. Urine bright yellow. 9 a.m., constant bruised pain in calves, back, and pectoral muscles, Noise of fluid in abdomen. Stool followed by rumbling. 5 p.m., soft stool preceded by much borborygmus and copious urine.

d. Jan. 7th, 6.15 a.m., ate one seed. Scraping when chewing it, especially in throat 6«45 a.m., warm feeling in stomach, emptor eructation. Head dazed, giddy. Much rumbling in bowels. Bruised feeling sinks from knees into legs, and becomes fixed in ankle-joints. Heat in occiput. Pain through dorsal muscles ; pressing in I. calf. Heat in stomach increases. Anxious feeling in scrob. cordis. Pressing pain in 1. ankle-joint, upper arm, hypochonder and inguinal region. 7 a.m., constant crawling in I. big toe. Empty eructation, discharge of flatus ; frequent stitches behind cartilages of 6th and 7th ribs. Bubbling of fluid deep in abdomen and mmbling of flatulence. Calves stiff when walking ; constant urging to urinate ; drawing in back of 1. hand ; pressure in I. pectoral muscles affecting breath ; shooting in lumbar muscles. 7.45 a.m., belly moderately distended, soft, painful on pressure deep in umbilical region. Pressive pain in r.knee and I. calf on walking ; abdomen t3rmpanitic ; persistent feeling of warmth in stomach ; firequent eructation of air ; •crapy feeling in inner aspect of 1. tibia. Chilliness proceeding from lumbar ver> tebrae. Much borborygmus ; violent pains in umbilical region extending to I. hypo* chonder and I. side of thorax ; painful jerkrfrom navel to mmbar region. Urging to urinate. Persistent dryness and scraping in throat. 8.30 a.m., pain and distension of abdomen and urging to urinate continue. 9 a.m., soft stool; until i p. m. more urine than usual passed.— loth. 6.45 a.m., took i seed. Whilst chewing this (scraping in throat, which increases later. 7.45 a.m., heat and confusion in occiput, formication in toes, pressing in muscles of I. leg, especially lower part of calf ; pres. sure in forehead, burning not ears, pulse 6 or 7 beats slower, soft ; confusion of head and pressure in temples and muscles of r, upper arm, 9.30 a.m., stiffness in nuchal muscles, pulse 65, pressure in I. shoulder-joint ; urging to urinate ; qualmish feeling in scrob. cordis ; noise deep in abdomen ; drawing in dorsum of r. foot ; increase of saliva ; pressing pain in frontal muscles ; hot feeling in stomach, and spasm rising up to cesopnagus ; pressive pain in r. ankle-joint and r. pectoral muscles ; mocn boihonrgmus and pain in umbilical region.— 12, noon, ate » more seeds. Scraping while chewing and afterwards. 12.30 p.m., pressing in 1. calf, r. knee, r. wrist ; increased saliva ; nausea ; pressure on 1. frontal and temporal muscles, worst

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when sitting ; formication under sicin of both Ifgt and feet ; pressure in fotAtai. I p.m., black points before eyes, great heat and weight in head ; persistent nau&a iod gafivation; stitches in urethra ; heat in stomach ; tearing in 1. toes and dorsum of L foot ; nausea, inclination to vomit, a p.m., pulse slow, full, soft ; great exhaustion and heaviness of head; protrusion in I. inguinal ring on coughing; after some milk food nausea, heaviness and pressure in forehead, veariness and much chillinns in lumbar venebnc. 1.45 p.m., stitches in rectum ; head confused, unable to think; pains in muscles of lower extremities continue; pulse 87, large, full, bounding; much chilliness, cold finger-tips ; frequent urging to urinate, with stitches in urethra; when walking in room, some heart's beats which shake the chest ; nausea now i^ then. 4 p.m., painful pressing and stitches in neck of bladder, frequently ; much yawning with nausea, much eructation with persistent heat and confusion of headj bubbling of fluid in abdomen ; with the attacks of nausea there alwaj's were smubI in neck'of bladder, with drawing pain and urging to urinate, every attack of bladdej spasm commences with a twisting pain round navel, which then extend down tt neck of bladder. Before and after these much bubbling of fluid in abdomen ivi acid eructations ; better in open air. During all the time and on the m. of the iiti scraping in throat and painful chapped lip«. Stool on nth delayed, sdotyini hard. {A. k. Z., xxxiv, 178.)

1. a. Dr. Herinc took 4 small doses of and trit. of seeds. First headachentcf nally on forehead and r. zygoma for a few h. The usual stool, followed l>y hard stool, then a 3rd stool, soft, and a 4th with nausea and great flow of uliT)) later a 5th stool. A slight catarrh with cough was increased ; the throit fi swollen ; the following n. hollow cough. Subsequent effects : Soft haemorrhoidi swelling ; increased itching of nose when eating ; much excitement from ttifllii| cause; nocturnal attacks of anxiety causing constriction of chest, could norjtti sleep before m. During sleep perspiration and constant dreaming. Can with dimeull be roused from m. and noon sleep, moved about with an effort which did him gooJi

A. After triturating J., sudden attacks of cor)na, with sneeting, frequent of mucus which soon becomes yellow alternating with white discharge, long; with occasional coughs, with difficult expectoration; in the intervals easy hawking up of lumps of mucus ; at same time transient paiiu here and tl in head. Short cough ist d., worse ind d. Attacks of anxiety constricting d preventing sleep, n. Violent cramps and twitching?, the calves turned round tod shins. Without feeling cold or not declares he has fcver and must sleep, t?f Wine acts more strongly. Putting the hands in cold water relieves the symptoi immediately. Dryness in throat with thirst, but he dreads drinking on account the nausea, after some h. vomiting of food and a short hacking cough. (jftW Arznei^., 585.)

1. a. Dr. Humphreys took i dr. ist dil. Confusion and stupid feeling In he for t d. Nausea and burning in stomach for some h., after ^ h. Acute colJf transverse colon and borborygmus. Call to stool after | h. Restless n. from 8l of thought and palpitation of heart ; dry mouth all n.

b. Took 5 dr. and dil. Confused and stupid in head, «nd d. After tome headache, pressing in at temples to crown, for 4 h., goes off in open lir, »nd or 1 d. Itching of eyelids for several d. Pain in r. car fori b. Pale face with di rings under eyes, and d. Soreness in 1. angle of mouth. Extreme drj- feelini; moulli, followed by actual dryness of mouth and tongue without thirst all n. Tr and to 3rd d. ; then as if mouth were scalded to 6th d. ; always worse at n. Thi 4th d. Constant eructation of air for 28 h. Pain and uneasiness in abdoroetu feeling in stomach as during severe diarrhoea, all a.m., 3rd d. Feeling ofj and nausea in pr«cordia, afterwards a soft stool, »nd d. All a,TO. pain' navel. Some bellyache and feeling as if diarrhoea were coming, m. tnd d borygmus and rumbling in bowels all n., the same all d., relieved by walking air, returns in warm room ; and d. Soft stool for several d., thereafter coitivcneis, slight headache, pressing in at temples, 6th d. Stool at n., very unuiual. evacuation of urine clear as water. Perceptible increase of urinan- -icci exertion, e. 4th d. Pain in r. testicle and scanty urine, 4th d. Paio in _ after excessive coitus all 6th d. Drawing pain in genitals along inner side off. to knee, 6th d. Strong heart's beats for several d., throbbing pain in 1, clavic 3rd d. Pain and numb feeling from elbow to tips of 4th and 5th fingers, with b

causing inienabiHtjr, after | h. ; lasts } h., and it repeated after 4 d. alon? ulnar aerye. Violent itching, as from scabies, between thumb and index, increased oy rub* bine. Violent itching in the commissures between ist and and finger, relieved by Tabbing, m. 3rd d. Pain in both houghs, for several d. Restless tossing about and beating of pulse, all n. After lying down, sleepless for several h. with beating of pulse, 3rd. d.

c. Took 3 dr. and dil. Pain in temples, in-pressing and throbbing, extending ■ometimes to crown, lasting all d., worse m room, aft. i h. Itching and soreness m edges of eyelids, relieved by rubbing, aft. i h. Pain in 1., extending gradually to r. ngoma, ending in pain in r. ear, and d. Two hard painless pimples on middle of r. cheek which go off gradually. Itching and tension around mouth, relieved by rub. bing, aft. 1 h. Itching and tension in lips »nd d., ulceration, soreness and tension in r. angle of mouth, 4th d. Dry mouth without thirst after i h., then feeling as if moutb was scalded all n. and m. of 3rd d. Burning in gullet. Eructation all ist d. Sinking feeling in scrob. cordis and slight nausea, immediately. Pain in hypogastrium and call to stool. Pain around navel with rumbling, discharge of flatus and call to stool, m. and d. Pain in 1. testicle 3rd d. Strong heart-beats, aft. i h. Violent pain in 1. clavicle, a.m. 3rd d. Pain along 1. ulnar nerve, after i h. Several ■audi red papules on wrist and back of r. hand, and d., go off in a few d. Pain in firtt joint of r. thumb extending to wrist, m. and d. VioKnt pain in first phalanx of r. index extending to its tip after 5 h. Itching between r. index and middle finger and on outer side of palm, after 7 h. Sore pimple in bend of r. thigh, and d. Pain> (nl tearing in 1. knee and ankle, after 7 h. Violent rheumatic pain in 1. ankle.joint, 3rd d. Rheumatic pains in ball of r. foot, m. 4th d. Itchmg between toes, n. istd. (Ibid.)

1. Dr. Davis took 3 dr., and dil.. Sore feeling in soft palate. Tension in centre of sternum. Pain in region of 3rd 1. rib above nipple for some m. (Ibid.)

2. Dr. ZUMBROCK took } dr. tinct. Nausea and warm feeling m stomach after f h. Spasmodic stitches in stomach, after ) h. Feeling as if stool would come, which it does not till next m. In sacrum and rectum sore feeling as in diarrhoea, after i h. Prostration. Rigor all over, after i h. {Ibid.')

3. SOOBBIRAN swallowed a seed, which tasted at first sweet, then extremely acrid. After \ h. he had acrid feeling in gullet, that gradually extended with increasing intensity to stomach, and at length caused vomiting. {Jourti. dt Pharm., xv, 501.)

4. Vauthbrin proved oil of seeds on himself. After 3 dr., there was insipid taste of drug, very slightly nauseating, without acridity or heat ; after swallowing, this taste became more decided at back of throat. After ao m., there was loathing at stomach, continuing until he took food. From 10 dr. there was same sense of loathing, as after castor oil, or almond oil in which J^th of croton oil had been mixed. From 51 dr. there was colic in \ h., and in 4I ti. a small stool, followed by another ^ h. later. (Allen's EncydoptetBa, v, i8a.)

II. Pnsomngs. — 1. Headache j anxiety with burning in stomach j easy vomiting of a large quantity of watery, white-of^egg looking stuff j at same time watery diarrhoea, which gushed from him, with anxiety, coldness of body, shivering and clammy sweat, violent spasmodic pains in legs and cramps in calves, which were raised m lumps. These symptoms lasted several hours, and yielded to opium in wine. (6. de v., in Htring's Amer. Arxneipr., 586.)

a. In Porto Praya (Cape de Verde Islands^ a men ate the seeds of Jat., which grows plentifully there. One ate a handful, the other only 3 or 4 seeds. After ih. both had most violent vomiting and purging. The one who ate the smaller quantity had no more symptoms. In the other the muscles of the limbs were contracted by violent cramps, head confused, vertigo with great restlessness, breathing quick and easping, skin cold and damp, pulse small, thready, intermitting ; heart's action very irregular, and so weak its impulse could hardly be felt on the thoracic wall. This lasted several h. Reaction commenced after 5 h. Soon afterwards he fell asleep. Next m. nothiijg remained but irritability of stomach and great weakness. (Farqu. H ARSON, Am. Jour, of Mid. Set., quoted by Bering, Ibid.)

1. June aSth, James Cole, «t. 36, ate 5 seeds. After 10 m. burning in mouth and throat; sore pain in abdomen which was distended. A few m. later great nausea j in 1 h. vomited 5 times and was copiously purged. The burning in fauces and pain in abdomen continued j he felt hot and feverish. After i| h. copious sweat

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all over body, and he became so weak he could hardly walk. The next } h.flii weakness increased, he got very giddy, became delirious, and, lastly, iasoifibic. This continued »o m. After J h. he could walk to the hospital, where he afiitrf 4 h. after having eaten the seeds. He was very weak, complained of heat and in. ness in mouth and fauces, numbness of tongue and pain in abdomen j frire ptk ind anxious, pupils normal, hands cold, pulse 140, weak. Soon restored by upmm ud cordials. (Letheby, Mtd. Caic., July aist, 1848.)

1. Thirtf'three bovs ate the seeds in various numbers from 3 to 50, In woe the symptoms appeared in 10 m., in others not before x or s^ h. The irreptaD were pain and miming in throat and fauces; pain and distension of jWonxn; giddiness, vomiting, drowsiness, later purging of copious mucous and rict-w»ltt stools. Depression in some very great, in many dysuria : after effects th'rr«t, ft'O, hot skin, quick pulse, pupils dilated, in those who had taken a large quantity. Tl* drowsiness very marked. One fainted and fell after being sick and violently purged. The cases of 15 are given in detail, but the symptoms were all very much ilikt, differing mostly in degree. Several had severe cramps along with the purging lod vomiting. One became pulseless and almost comatose. One had vomiting Iwt no purging. (Afcd/. Ti/ntJ and Gax,, June 15th, 1864.)

2. Nov. nth, 1848, M — , art. 11, healthy, ate at 11.30 a.m. 15 to 10 tcttk I p.m. burning in throat and stomach with restle.ssness and urging to stool. Sone profuse purging, at first of dark faecal matter, then of thin or nearly watery dischaim with great pain, sinking of abdomen and vomiting. At t.30 p.m. cramps in fe, legs and thighs. At 3 p.m. purging ceased but cramps continued, aoa wrrr •» severe that patient sprang in agony out of bed and stamped his naked feet with ill his force on the ground as if to flatten them, as the cramp distorted them. The cniBpt were not confined to lower extremities, but were, though not so severe, in nuaclesrf abdomen, arms and backj occasionally convulsive twitchings in back like tetanus. When the cramp commenced he began to lose sense of hearing; this increued till 3.30 p.m., when he was so deaf a.s to appear insensible to the loudest voice rillinf it his ears j sight dim, could not recognise those about him. From i to 4 p.m. p«l(» very small, thready and weak; skin cold, damp, clammy ; features sunken and «»• tracted and he was quite exhausted. Brandy and opium failed to give relief hkO 6.30 p.m., when the body became warmer and pulse stronger. Then the ci gradually declined till midnight, after that only about once in 1 h. He got sleep and was better in m. Next d. remained totally deaf, occasional cramps, t« ness of abdomen on pressure. The and d. the hearing returned and he «a« well. Though he seemed quite conscious during the illness, he had when he recovered w remembrance of anything that had happened after the purging, (Marrett, MtiJrti Siuarl. Joum. qf Mtd. Scitnct, 1861, lii, 37.)