Paullinia sorbilis, Mart.

Natural order , Spindaceæ.

Common names , Guarana, Gurana-üva, Brazilian cocoa.

Preparation , Triturations of the seeds.

Authorities.

1 , Montegazza; general effects of 1/2 to 4 grammes; Bull. Gén. de Thérap., August 20th, 1867, from Annales d'Omodei, April, 1865; 2 , Dr. W. Macdowell; J. D. G., aged 28 years, took 1/2 a drachm, first day; 1 drachm, twice, second day; 1 drachm, three times, third day; 3 drachms, fourth, fifth, sixth, and seventh days; 4 drachms, eighth day; Practitioner, Sept. 1873, p. 172; 3 , J. G. took 1 ounce in drachm doses, ibid.; 4 , Dr. Macdowell himself took 30 grains, twice, first day; 30, 45, and 60 grains, second day; 90 grains, twice, third day; 90 grains, four times, fourth day; then after two weeks' interval, 1 drachm, first day; 3 drachms, second and third days; 8 drachms, fourth and fifth days; 1 drachm, three times, eighth day; 1 drachm, twice, ninth day; 1 drachm, three times, tenth and eleventh days; 2 drachms, 4 times, twelfth day; ibid.

MIND

Gayety, 1.
Extravagant behavior, 1.
Mental hyperæsthesia; intellectual excitement, 1.
He thought he was more lively and readier for work than usual, 3.
Unusual humor for continued hard work (second day), 4.

HEAD

From 9 P.M. till bedtime my head felt rather confused; I was quite "out of sorts," and unable to settle to work (first day), 4.
He awoke at midnight, and complained of a tightness across the forehead (second night); he fell asleep shortly, and had no return of pain in the head when he awoke next morning, 2.

EYE

Persistent twitching of the eyelids (after first dose, second day), 2.

STOMACH

Loss of appetite, 1.

STOOL. [10.]

Bowels moved normally at 10.30 A.M., and a small motion occurred at 8 P.M. (fourth day); operated normally at 11.45 A.M. and 10.15 P.M. (fifth day), 4.
Slight constipation, 3.
Very slight constipation (third day), 2.
Bowels operated at noon; decidedly constipated (second day), 4.
Bowels operated at 11.45 P.M. for the first time for about seventy-two hours; a very unusual occurrence for me to be so very long constipated (third day), 4.

URINARY ORGANS

Spasm of the bladder, 1.

HEART AND PULSE

Diminution of the heart-beats, 1.
Before the proving the pulse averaged 70 in the morning; 75 at midday and during the afternoon; 78 at 9 P.M.; 75 at midnight; during the proving, 73 during the morning; 70 at midday; 76 during the afternoon; 78 at night, 4.

GENERAL SYMPTOMS

I felt unsettled, restless, and unable to work with vigor; there was a really distressing fulness and throbbing in the head, chiefly in the temporal regions, afternoon and evening (second day), 4.
Spasmodic restlessness, 1.

SKIN. [20.]

Urticaria, 1.
Prurigo, 1.

SLEEP

Sleeplessness, 1.
(It prevented or removed drowsiness after food), 2 . [He found that our diet had a very soporific effect upon him; indeed, if I mistake not, he got into trouble on one occasion for falling asleep dinner when he was on duty; he found that a drachm of Guarana entirely prevented this heaviness, and he did not experience that feeling of congestion of the head which occurs so often a liberal meal.]

FEVER

Temperature before the proving averaged 98.3° during the morning; 98° at midday; 98.1° during the afternoon, at 9 P.M., and 98° at midnight; during the proving, 98.3° during the morning; 98.2° at midday; 98.1° during the afternoon; 98° at night, 4.

SUPPLEMENT: GUARANA. Authority.

5 , V. Franque, Bayer. Intell. Blat., No. 17, Schmidt, vol. cxv, p. 291 (Sydenham Yearbook, 1862, p. 459), effects of doses of 16 to 20 grains; 6 , German authority, quoted in Bost. Med. Journ. (New Remedies, vol. v, 1876, p. 339), a patient suffering from facial neuralgia, due to a central lesion, took Guarana; 7 , same, effects.

Giddiness, 5.
Tinnitus aurium, 5.
Dysuria is a frequent phenomenon, 7.
Redness of the face, staring eyes, slight irregularity of the pulse, moisture of the skin, delirium, dulness of hearing, and vesical and intestinal spasms, 6.
After its use in neuralgic headache, phenomena of its poisonous action may be observed from the appearance of a malaise, more distressing than the headache, which has disappeared under its remedial agency, 7.
Sensation of pricking and cold, extending to the whole cutaneous surface, 5.

Guarana