Colchicum autumnale

Volume II — Main text

COLCHICUM .

Cólchicum autumnale, L. Meadow-saffron. Nat. Ord., Melanthacea. I. Provings.- 1 . [The following provings were made with the tincture prepared by mixing equal parts of the expressed juice of the root obtained in spring and alcohol, all except the proving by Bethmann, which was made with the tincture of the seeds. No information is given as to the doses taken or the persons who proved under the inspection of the reporters, and but little as to the period after ingestion when the symptoms appeared.- EDs.] HAHNEMANN.-Tearing and tension in l. side offace to ear and head ; menses 7 d. too soon; shooting-tensive pain between scapulæ, chiefly when moving, so that he must walk crooked for some time. (Archiv, vi, 1, 147.) 2. STAPF.- Immediately, nausea and no appetite. After 3 h., great distension of abdomen as though he had eaten too much, though he has eaten nothing; after partaking moderately of light food this feeling becomes much stronger and more tiresome. No time mentioned: obnubilation of head ; a sort of headache ; formication under forehead ; heat of mouth, thirst ; disagreeable feeling in stomach as it raw ; pain in abdomen as from incarcerated flatulence ; pressure in abdomen ; tendency to diarrhea ; urging to urinate, urine darker than

usual ; exhausted as after exertion ; restless sleep; heat of body, n.; sweat ; out of humour, mistrustful, fears everything that occurs. (Ibid.) 3. SCHWEIKERT.-After h., increased saliva, accumulation of water in mouth. After h., violent pressure in r. occiput ; in interior of nose warm feeling as in epistaxis ; tensive pain in r. cervical muscles externally and felt when swallowing ; occasional oppression of chest ; sleepiness, dislike for work, and confusion of head. After 1 h ., forcing feeling from abdomen to chest with anxiety and heat, especially of head, lasting 2 h. After 1 h., feeling in nasal bones as from pressure of a weight. After 24 h. , drawing pain in teeth, like what occurs on drinking something cold after something hot. After 3 h., drawing pain in front teeth lasting 10 h.; anxious oppression of chest all d. After 9 h., some transient stitches in middle of tongue. The first 12 h., urine somewhat increased, with some urging. No time given : crawling in tip of nose; tearing in r. upper and lower jaw, with feeling as if teeth there were too long ; great flow of saliva all d.; several times nausea during dinner ; urging to stool, with small hard stool or none at all, with pain in anus frequently during d.; pressive pain in chest all d.; pain in lumbar region ; tingling and formication in single toes, in r. ball, in fingers, ears, and some places on skin of face, as after being frozen, in e. (Ibid.) 4. VON GERSDORF.-Soon after taking med., sneezing. No time given : pressive pain on a small spot on r. side oftop of head,transient ; here and there in head short squeezing pains in circumscribed spots ; tearing in 1. half of head up to crown ; pressive-tearing pain in a small spot on r. of occiput ; transient squeezing headache close above eyes ; tearing in a small spot of 1. occiput ; formicating boring tearing on a small spot on r. side of top of head, later the same pain came on corresponding spot on 1. side ; tearing in r. temple, tearing tension on a small spot on 1. half of forehead as if an ulcer would come there ; drawing on 1. side of top of head going down to nose ; eyes painful ; pressive pain in r. eye ; quivering in r. upper eyelid ; slow visible drawing (like quivering) in l. lower lid towards inner canthus ; short violent sharp tearing in and around r.eye ; smarting in r. eye, especially its outer canthus, with some lachrymation and feeling as if lids stuck together ; suppuration of a Meibomian gland on 1. lower lid with swelling of lid ; the nerves are much irritated ; tearing behind r. ear near maxillary joint, when touched it pains for some time ; earache, then pricking in interior of ear as with fine needles ; pricking shooting in l. ear ; creeping in nose ; sore pain in septum of r. nostril,very bad on touching part and moving nose ; squeezing sensation in upper part of nose ; sharp cutting tearing in 1. side of vermilion of upper lip ; squeezing pain in r. maxillary joint ; boring on r. side of nape, externally ; pressive pain on r. upper part of neck under ear, opposite maxillary joint, painful when touched ; pressive pain in muscles on 1. side above larynx, on throat and in larynx ; sore pain in teeth ; painful prickling in upper molars ; tearing in roots of 1. lower teeth ; pressive pain in l. lower molars ; tearing high up in gums on r. side above a place where a tooth had been lost , tearing in gums of l. lower front teeth ; tearing in l. side of back of tongue ; smarting creeping at back

of fauces ; great formication in throat exciting coughing and hawking of mucus ; tearing on 1. side of back of fauces ; constant creeping formicating sensation at back of palate as in catarrh ; much mucus collects in throat of a greenish colour ; during the formication in throat this mucus is detached, which must often be spat out ; in m. rough in throat with hoarseness ; on sneezing greenish mucus is often involuntarily ejected by mouth ; much empty eructation in forenoon ; slight feeling of oppression in scrob. cordis ; burning externally to r. of scrob. cordis ; during supper out-pressing bellyache, close under scrob. cordis, relieved by eructation ; tearing in cardiac region ; when walking, m., severe pressure in upper part of abdomen ; just under r. short ribs in front pain as from incarcerated flatus ; some cutting tearing on r. side of upper abdomen ; squeezing pressive sensation in 1. side of upper abdomen, extending to hip, transiently relieved by eructation ; pain, as if raw internally, also when touched, between 1. hip and ribs ; before and at commencement of dinner pressive pain about umbilical region with flatulent distension ; violent sharp stitches in umbilical region ; sharp out-pressing on 1. above navel ; squeezing and tearing pain in abdomen near r. hip ; shooting here and there under umbilical region ; pricking tearing in anus ; creeping and violent itching in anus ; intermittent burning in anus ; tearing deep in nates, towards anus ; burning in anus ; stool not hard but scanty, pressed out with much effort ; constipation for several d., and when he has a stool it is very small ; first turbid, then bright yellow urine ; more micturition than usual ; in bed, m., after passing urine, intolerable creeping burning in urethra, with feeling as if more were to come, and when a few drops were passed burning as if they were red hot ; at same time burning in anus ; drawing sensation in most posterior part of urethra, cutting in anterior part of urethra ; tearing in glans penis ; formication in nose with sneezing ; long-continued coryza, which is never very fluent, and in which much nasal mucus is expectorated ; formication in trachea and in chest with cough ; frequent tensive feeling in chest ; squeezing pressive feeling in chest ; obtuse tearing pain in r. side of chest near axilla, which is followed by a sore feeling when touched or moved ; burning stitches as if externally on r. side of chest ; obtuse stitches in r. side of chest ; in bed, m., and later during exercise several violent stitches in 1. side of chest; during inspiration and coughing stitches on 1. side of chest ; violent stitches from within outwards in r. side of chest ; on forcible expiration an obtuse stitch in l. side of chest, not when inspiring, but afterwards only when inspiring ; sharp stitches in r. side of chest ; violent stitches on top of l. side of chest ; obtuse shooting pressure in top of r. side of chest near arm ; intermittent pressure,sometimes above, sometimes below, on small spots of r. side of chest ; obtuse shooting tearing deep in interior of r. thorax, it is hard to tell whether it is more in the chest than the back, to which it seems to extend ; tearing in back to 1. of spine ; burning stitches in sacrum ; severe pressive, obtuse enduring stitch in back under and between both scapulæ ; violent throbbing in 1. axilla that can be felt with hand ; squeezing pain on 1. shoulder ; pain in a small spot under and almost in r. axilla as after a blow ; frequent tearing-pressive pain in r. then in l. axilla ; con

tinued obtuse stitch on upper inner angle of r. scapula ; throbbing on external aspect of left upper arm; dull tearing pressure behind r. axilla ; burning-pressive pain on inside of 1. upper arm near axilla ; tearing on inner side of r. and 1. elbows up arm ; tearing in forearm near wrist ; tearing in r. wrist ; tearing in back of r. hand ; tearing in and below distal phalanx of r. little finger, sometimes very violent ; r. hand trembles so much he can scarcely write ; tearing in middle phalanges of r. middle and ring fingers ; shooting tearing in lower part of r. hand ; rheumatic drawing in distal joint of 1. thumb ; pain in distal knuckle of r. thumb, as if a splinter was sticking in there ; tearing under nail of 1. index ; tearing in proximal joints ofr. little and ring fingers ; pressive drawing in under part and ball of r. thumb ; tearing in hip ; squeezing pressure on and above r. hip ; jerking tearing in upper part of r. thigh ; tearing in r. thigh about hip ; tearing in upper part of 1. thigh ; tearing on inner side of top of r. thigh ; tearing in middle of 1. thigh in e. in bed ; violent paralytic drawing in whole of r. thigh in e. in bed ; cramp in 1. thigh as though it were asleep ; tearing pain just above 1. knee in e. in bed ; pressive pain in inner side of r. knee ; tensive tearing on lower half of 1. tibia ; transient tearing from 1. hip down to leg ; tearing in outer side of 1. calf; tearing in lower part of r. calf ; drawing tearing on r. instep ; tearing in a small spot on r. foot 3 fingers' breadth below ankle near sole ; tearing in inner bend of r. foot betwixt ball of big toe and heel ; tearing in l. ankle-joint ; tearing in l. sole near toes ; tearing in r. heel near sole ; pressive-drawing pain in l. big toe, then in r. big toe, then in middle 1. toes, the pain seems to be mostly in lower aspect of toes ; the l. big toe is painful as though the nail would grow into the flesh ; shooting tearing in lower side of ball of r. big toe ; formication in inner surface of r. big, 2nd, or 3rd toes as if asleep ; a painful sharp boring stitch over nail at tip of r. big toe ; cold feet and hands ; here and there on body, e. g. below scrob. cordis on r., in side of 1. ribs, below axilla, in r. hough, tearing tension in small spots ; trembling empty feeling of whole body in afternoon immediately after dinner ; frequent starting in affright out of sleep, with an idea that there are mice in the bed (on 2 successive n. ) . ( Ibid.) 5. BETHMANN made his provings with tinct. sem. colch. in pretty large doses. After 4 h., great flow of watery saliva with nausea, fulness and distension of abdomen. After 5 h., the features are completely altered, like those of a person who has long been ill ; very sick, with salivation and dryness of throat, he turns hither and thither in a disconsolate manner, with very distracted mind and prostration. After 6 h., violent vomiting of food taken 3 h. previously. After 4 d., the smell of a newly beaten-up egg almost made him faint. After 8 d., very copious salivation. After 13-15 d., weakness of memory ; he forgets the words he was just going to say, and can only with difficulty recover the former train of thought and go on talking. No time mentioned : very forgetful and distracted ; pressive weight in occiput, especially when moving or stooping forwards ; a very fatiguing though not violent pressure deep in cerebellum from the slightest mental work. Sharp, very painful, drawing tearing in 1. half of head, generally commencing in l. eyeball and extending to occiput, for several d.; fine tearing in

scalp ; hair falls out very much ; drawing digging deep in eyeball ; melancholy expression ; jerking-drawing pain in facial muscles,deep in bones ; in facial bones very disagreeable feeling, as if they were driven asunder laterally, with single drawing jerks ; squeezing pain in ears ; on making a few steps in the room, ears felt stopped up and tinnitus ; tearing in orifice of r. ear ; the smell is so morbidly exalted that something quite indifferent, e.g. soup, makes him almost sick ; epistaxis in e.; the masseter muscles felt as if drawn in their breadth, allowing the mouth to be opened only a little and with pain ; the teeth so sensitive he cannot bite ; at entrance of œsophagus sensation as if there were there a high, round swelling when drinking ; inflammation of all the fauces ; much spitting of watery saliva ; watery salivation with dryness of mouth for several d.; on swallowing saliva there occurs nausea and inclination to vomit ; loss of appetite ; appetite for various things, but on seeing or smelling them he has loathing and cannot relish anything ; any strongly tasting things feel as ifhe were chewing linen ; hiccup for hours ; constant eructation of air ; nausea when in erect position ; when she stands up a creeping in stomach as if about to vomit ; relief after vomiting ; before vomiting abdomen painfully contracted ; violent retching, after retching for a long time a large quantity ofyellow bitter mucus is ejected, which leaves a bitter taste in fauces ; after violent griping she vomits bile several times, afterwards bitter taste in mouth and throat ; he must lie quite doubled up without the slightest motion all d., otherwise the vomiting which continues becomes still more violent, every movement increases and renews it ; he can only lie on r. side, at every movement and change of position the vomiting returns with frightful violence ; cannot bear the slightest touch in gastric region ; crawling (in stomach ; stomach feels icy cold ; in abdomen , especially in stomach, a slight chilly feeling with pain and weakness ; pain and discomfort in whole abdomen ; thin stool preceded bygriping ; rumbling in bowels as if diarrhea would come on ; watery diarrhea ; often thin watery stool passed without sensation ; spasm in sphincter followed by chill in back and then urging to stool without being able to get rid of all the excrement; often obliged to go to stool without result, preceded by griping ; increased secretion of urine ; on passing urine burning in urethra as though it were raw; drawing and tearing pains in urethra ; tearing in l. spermatic cord ; the menses, which had justcomeon,stop ; single stitches in dorsal muscles ; stitches in sacrum ; drawing in sacrum, increased by movement ; on the middle of sacrum there is a spot the size of the hand, with pain like an ulcer, extremely painful at the slightest touch ; violent paralytic pain in arms, so that he cannot hold even light objects ; third and fourth fingers of r. hand drawn inwards ; tearing in joints of r. fingers ; shooting tearing in ligaments of joints of r. little finger ; drawing tearing deep in l. hip-joint, apparently in its ligaments , worst at n.; drawing deep in muscles of thighs ; drawing tearing in l. sole ; sudden tearing jerks through half ofbody, like electric shocks ; sometimes shooting, sometimes jerking drawing at one time in muscles of shoulder, at another in r. hip ; slight drawing and twitching, also tearing in incisors, eyelids, facial and other muscles ; the pains seem to be quite intolerable in e., he feels disposed to be angry with himself ;

all kinds of pains are worst from commencement of n. until dawn of d.; his gait is uncertain and staggering, partly from weakness and partly on account of the drawing-shooting jerks darting suddenly through periosteum, which are always attended with a paralysed feeling and an actual though transient paralysis ; sleepless almost all n. on account ofshooting jerking ; the pains are much aggravated by mental exertion ; she has often single tearing jerks, chiefly on 1. side ; the smell of pork (which he formerly liked) , a bright light, a touch, the naughtiness of a child, put him almost beside himself ; such extreme depression of spirits, weakness, pain, and sensitiveness of the whole body that he can hardly move without moaning ; rapid sinking of strength, so that in 10 h. he is hardly able to speak so as to be understood, or to walk in room ; she feels such weakness in muscles of extremities that she thinks they will fall off; all muscles, especially of lower extremities, as if paralysed ; quite powerless and as if paralysed in all the body, especially the arms ; the painful muscular paralysis, especially in knees, causes them to knuckle under him often, especially when he lifts his legs to step over an elevated object, e.g. the doorstep ; itching of skin in several places ; pricking on skin, causing twitching through whole body ; sleepiness by d.; must yawn often ; rigor through all the limbs ; dry heat of skin ; violent palpitation of heart ; pulse large, full, hard, from 90 to 100 ; suppressed perspiration ; cross, ill-tempered, nothing pleases him ; his 6. sufferings seem to him æt. Dr. LINDEMANN, intolerable. 39, liable( Ibid.) only to slight rheumatism , catarrh, and sluggishness of stool, took, Jan. 16th, 17th and 20th, a . dose of 15th dil. Noticed unusual appetite, and on 18th, unpleasant epigastric sensation, almost amounting to pain, on pressure, coughing, and deep breathing. On 24th, took 3 dr. of same. In afternoon, uncalled-for shivering ; appetite same ; disturbing flow of thought after midnight ; dulness about forehead, which is cold ; on surface generally slightly sour-smelling perspiration. In m., forehead warm and heavy, head dull ; fingers cold, palms hot ; shivering again in e. On 26th, took 4 dr. On 27th, towards and after mid-day, oppression in cardiac region, with fluttering pulsation. Took 6 drops at 4 p.m. Next d., at noon slight cardiac uneasiness. On Feb. Ist and 3rd, took globules of 3rd dil. without effect save a not unusual bruised pain in loins. On 4th, took 3 dr. ofsame, with no symptoms save such as a slight catarrh would occasion. Same result from 4 dr. on 7th. Appetite remained unusually keen. From 4 dr. on 14th and 16th, and 6 dr. on 18th, no further effects. Same to be said of doses of 2-8 dr. of tinct. taken March 9th- 16th, save that frequent micturition was noted, and some itching at anus. On 28th, took 2 dr. at 4, and 3 dr. without water at 7 p.m. At 6, slight itching at anus, shivering, knees feel tired in ascending. At 7, urgency to micturition ; uvula somewhat painful and congested. After 2nd dose, warmth and fulness at epigastrium, with cardiac uneasiness and oppressive swimming in head, going off in h. L. arm feels cramped and weak. At 7.30, passed unusual quantity of scalding urine. Great drowsiness after supper; frequent micturition and much Took dreaming at n. 29th.-By 9 a.m., all symptoms gone. 3 dr. without water. VOL . II . darting pains Same immediate effects, with 21

in hips. Repeated dose at 11.30; sensations at epigastrium alone perceived. P.m. , while sitting, warmth and beating in loins ; forehead feels distended ; inability to fix attention. In e. and n. vesical and rectal tenesmus, urine scalding. 30th.-8.45 p.m., 6 dr. In addition to epigastric sensations, aching just above anus, where there is a sensation of creeping, with warmth, itching, and slight burning, as if from a mustard plaster. At 9.45, pulse 87, cardiac oppression and frequent micturition. At 10.15, repeated dose. After 10 m., feeling of exhaustion in going upstairs ; cardiac oppression, with slight momentary fluttering and darting pains, and feeling of anxiety, with sighing ; decided twitching in back (which had been slightly felt before), and sense of heat in spine. These symptoms, with previous ones of anus and urethra, continued more or less all d. He ate with great appetite ; sensations in back extended to 1. hip ; cheeks at 4.30 red and hot. 31st. Four dr. at 6.30 a.m. brought back symptoms of back and 1. hip, relieved by stool and walking. Another dose at 9.15 recalled them, with weariness of knees and the cardiac and rectal uneasiness . Another, at 11 , resulted only in much flatulence and belching. Similar doses next d. brought on similar symptoms. ( HARTLAUB's provings, Hom. Vierteljahrsch. , viii, 208.) 7. W. S-, woman of 24, single, in good health save for rather frequent headache and costiveness. After 2 doses of 20 gl. of 15 dil . nothing but increased appetite. After 2 dr. of same in water very restless n., with nightmare, and next m. weakness of limbs. Feb. 2nd, at 9 a.m., 20 gl. of 3rd dil.; immediately, chilliness in room, giddiness and palpitation all d. Last symptoms recurred after 40 gl. on 5th . After 2 dr. on 7th deep sleep, weakness in limbs. After same on 10th , at 9 p.m., burning heat and giddiness. On 17th, at 9 a.m. same ; pulse before taking it 70, 2 h. later 60, in e. 65. March 6th.-Four drops ; palpitation. On 10th, took 2 dr. of tinct.; pulse before taking it 70, 2 h. later 65 and very weak, in e. 57, an h. later 70. On 14th, 4 dr.; chilliness in thorax ; eructations with water. On 17th, 4 dr. in e.; pulse after taking it 50, after an h. 60, next m. 60, towards noon 75 ; heat in forehead ; giddiness. ( Ibid. ) 8. C. Sch-, woman of 30 and single, strong save nervous system. Doses of 15th dil. taken while a catarrh was passing off, seemed each time to renew it ; she had also after one dose itching over whole body, and a slight eruption . From 3rd dil. later, she had pain in stomach, giddiness, and sense of great weakness on getting up in m. With next catamenia (unwonted), heaviness and aching in feet. From tinct. some palpitation and giddiness with, on one occasion, singing in ears and debility, also great appetite. ( Ibid.) 9. Dr. GSCHLADT, æt. 35, thin and weakly, venous constitution, bilious temperament, great irritability, pale face, dark complexion. Dec. 30th, 1853, took 20gl. of 15 dil., at 4 p.m. Soon after, frequent flatulent eructation ; repeated yawning ; dizziness after walking, so as to cause fall from chair. In e., unusual drowsiness. Deep sleep till midnight ; then woke with heavy pressure on stomach, and lay awake for 2 h., with audible palpitation,dry heat of surface, dry mouth, slight darting pains in wrists and elbows, dragging pain in sacrum . Woke

tired in m.; boring pain over eyes ; sacral pain better on moving ; face paler ; eyes dim ; copious stool. Appetite great. P.M., persistent chilliness and unusual drowsiness. Irritability greatly increased all d. Good n., and next m. quite well. On Jan. 4th, at 4 p.m., took 100 gl. of same, with similar results, including also palpitation on 1st d., and nausea to vomiting on 2nd. Sacral pain extended to hip. On 10th, 25 gl. of 3rd dil., with similar results, heart being also oppressed. On 14th, 50 gl. produced same effects, with giddiness. (He woke each n. after dose at midnight, and lay awake 2 h. as at first.) Same also from 2 dr. of 3rd on 19th, and 4 dr. on 24th. About this time he became aware of existence of two dry wart-like growths on neck, which had arisen during proving, and after 6 weeks disappeared by scaling off. On Feb. 4th, took 2 dr. of tinct. at 10 a.m. Same general effects, but colicky pains, weakness of limbs, and general weariness and restlessness were added, and there was more decided pain in joints (shoulders and knees) . On 12th, 4 dr. Same symptoms ; joint pains relieved by motion (as before) . On 13th and 14th urine copious, golden yellow ; clear at first, but afterwards showing a suspended white cloud. March 15th .- Six dr. at 9 a.m. Same symptoms, but more marked ; in afternoon drowsiness, shivering, pallor, anxiety about heart, hunger, variable pulse. Next d. with other symptoms, tongue white ; and on 17th, urine slightly scalding. On 31st took 6 dr. at 9 a.m., 8 at 3 p.m., 10 at 8 p.m. with renewal of all old symptoms, also ringing in r. ear and deep hollow voice. The action of the several doses taken throughout seemed to extend from 24-72 h . (Ibid.) 10. a. Dr. BRUNO LINCK, bilious temperament, strong and healthy, but with tendency to catarrh and colic. Jan. 19th, 1853. Shortly before going to bed, took 4 dr. oftinct. After lying awhile in bed blood began as itwere to boil, sweat on chest and head, peculiar feeling at heart with some irregularity of beat, and pricking and itching in several parts. Sleep afterwards sound. Repeated dose next e., with similar results ; itching was burning, and scratching sent it elsewhere ; also some cutting in abdomen. After same dose next e. on blowing nose same cutting pain, but in lower anterior thorax; nothing else noted. On Feb. 5th took 5 dr. gradually during m., and p.m. 4 dr. at once. In h. after last same cutting pain on 1. side, uninfluenced by breathing ; dulness in head. In e. remittent dragging pains in thigh-bone, and headache about 1. temple, relieved and finally disappearing in bed. Sleep good. 6th.-Quite well on waking ; but after rising headache gradually returned, and by e. was severe, pain heavy and dull, in upper and back part of head ; with it great tension of jaws ; relief after supper and gradual decline in bed. On waking after a good n. pain only on small spot of r. forehead, pretty severe for 10 m., but remaining in less degree all d.; also pain in l. thorax as before. On 8th and 9th feeling all d. as if headache would return ; on latter thoracic pain, shifting from r. to 1. and appearing lower, at last settling into persistent pain over spleen ; in e. colic and threatened diarrhea. On Ioth splenic pain had disappeared, but he had pinching and cutting here and there on chest, and, for a short time, in l. arm ; also wandering pains of burning itching character, after scratching skin becomes red, and pains

shift. On IIth and 12th free from all complaint, but at n. could not lie comfortably on 1. side from splenic tenderness. b. After repeated experiments with a tinct. from an old schoo. pharmacy, very feeble indications of action were manifested, although he took 15 and even 20 dr. at once. The only marked and recurring symptoms were oppression in head, tearing pain from r. patella backwards ; cutting-tearing pain in hepatic region ; burning itching in various places almost simultaneously ; dragging in 1. hypochondrium. c. Again proved homœopathictinct. (equal parts ofjuice and spirit). On March 13th took 10 dr. with water. Slight pain in l. testis, very sensitive, as if squeezed, on putting down 1. foot in walking, evidently from jar (nothing felt on pressure) ; nausea ; cutting-tearing pains on chest. In e. pain in testis again for some time, tearing pains on outer side of l. forearm, as if in fascia, sudden shooting-tearing pains in lumbar region on both sides. 13th-Oppression in upper and back parts of head ; tearing pains about 1. foot ; severe pain in leg, as if from cold, especially on tibia, with coldness of leg and of whole body, even in bed ; a.m. , pain in testis as before.- 14th. Same feeling in leg ; cutting and tearing pains in chest. 15th.-Pinchings on tibiæ, with coldness in bones (as yesterday) ; while writing such violent pains over r. thorax that he was compelled to desist, unaffected by movement or deep breathing, then suddenly such a severe crampy pain there that he started up in affright. 16th.-Tearing under patella ; pain at end of one finger on palmar surface as from a splinter, recurring at intervals. 17th.- Took to dr. of officinal tinct. seminum. Slight occasional pain in extensor surface of 1. forearm, extending to some fingers ; pinchingtearing pain in r. tendo Achillis ; lachrymation in open air, so as almost to impair vision (noticed slightly for several d.) ; smell as of smoked ham under nose ; pressive pain on 1. eyeball ; very sensitive pain in front of shins ; dull pain as from cold, or like " growing pains " in bones ; very sensitive drawing in l. forearm on extensor side, as if some nerves were being stretched, at intervals ; remarkable chilliness of skin on hands and feet even in bed ; coldness of whole body even in a room ; small round pimple on m.m. of lip. 18th.-In e. 10 dr. Long stitches in 1. elbow, spot remaining tender for some time ; tearings, very fine but penetrating, on extensor surface of 1. forearm to fingers, like electric shocks ; severe twitching pains like fleabites in several parts, requiring scratching, then disappearing ; about I h. after dose rough dryness in throat ; coldness on knee. d. On March 13th, 1854, commenced proving of dilutions by taking 5 dr. of 15th . No symptoms. On 14th, 6 dr. in m. Hiccup, not specially painful, disagreeable jerks ; nausea in throat, as if on point to vomit, for 2-3 h. On 18th, same. P.m., headache, pain quite internal, across base of brain between ears, not very severe, rather unpleasant. 23rd. In e. , same. In m., throat at back quite dry, with painfulness on swallowing, as in commencing catarrhal angina. This symptom was the more noticeable because it had been felt on former occasions when this dil. was taken in m., but then ascribed to a cold. Each time it disappeared in an h., after washing out mouth. In neighbourhood of 1. nipple, on spot about 1 in. in diameter, deep in

chest a raw pain, very keenly felt, increased by respiration and in proportion to depth of each inspiratory act, better soon after rising, and then wholly disappearing. P.m. , urging to stool ; passage of formed but not hard fæces was exceedingly painful, and must be effected with great caution, feeling being as if sphincter would be torn. On retiring to bed, still painfulness in anus. 25th. In bed again pain in chest, disappearing after rising. Itching deep in ears (also felt on former days), ears inside quite dry, desire to bore into them, but it does not seem to reach itching spot or relieve. To-day, as yesterday, frequent slight expectoration of glutinous or starchy mucous lumps from chest, without irritation to cough. On 27th, e., 5 dr. of 3rd dil. On 28th, p.m., fine sensitive tearing in 1. shoulder-joint anteriorly. On June 15th, same dose. During whole d. periodically uncommonly large emissions of excessively offensive wind (most uncommon) ; copious evacuations, not thin, followed by feeling in rectum as of diarrhea, and gnawing in anus. Sleep quiet, many dreams, always of same objects, confused and indistinct. 16th .-Same dose in m. fasting. After dinner, pain in hypogastrium and anus as of threatening diarrhea, urging to stool, aching in abdomen, then everything disappeared again. About 3 p.m., unconquerable drowsiness (unusual). 17th.-Same. In course of d. severe rheumatic pain in 1. shoulder and neck, mostly pressive and tensive, hindering free movement, especially bending to 1. and backwards. P.m.,again at same time drowsiness. During ahard stool pain as from tearing of sphincter. Fruitless urging to stool, though fæces are still felt in rectum, which seems inactive. Stitches under r. mammæ, as if in lungs . ( Ibid.) 11. LOUISE LINK, æt. 35, strong, but emotional and liable therefrom tonervous derangements. Feb. 5th, 1853.-Took 5 dr. oftinct. in water. Soon after, feeling of giddiness and reeling in head ; pain in bone over 1. eye, returning with increased severity at each movement, but from noon to 6 p.m. increasing to such a height that any slight noise became unbearable. Pain continued all next d., increased by any movement of head ; and on 7th shifted seat to r. vertex at back, aggravated by bending head back or raising eyes, with great longing for repose. On 8th, this was hardly noticeable ; but she had suddenly a very severe cutting pain, as from sharp knives, in l. chest, almost suspending respiration and compelling her to moan ; the severity lasted h. , but some degree of pain persisted. From 6-8 p.m., return of pain over 1. eye, extending over whole 1. head, passing off after supper with cuttings in abdomen (which had also been noticed on previous days). Head and chest symptoms recurred also on 9th, with also pain in region of stomach, which feels swollen (though it is not) and is intolerant of pressure ; cutting in abdomen is continual, with much urging to stool, which-when it comes-is difficult though soft, and followed by pain in sacrum. At 11 , headache was accompanied with great restlessness in all limbs, which a dose of pulsatilla quieted. Same symptoms next d., but free from them afterwards. (Ibid.) 12. Dr. SCHLOSSER, æt. 30, in perfect health, save for liability to a r. supra-orbital neuralgia on provocation (especially psychical) . On March 5th, 1854, at 8 a.m., took 5 dr. of tinct. without water. Some

local irritation followed, and at 3 p.m. troublesome pressure deep in sacrum. In e. continuous aching at junction of sacrum with last lumbar vertebra (a sensation he had had occasionally before) ; at 8, painful pressure in r. outer ankle, as from fatigue. In n. frequently wakened by persistent pain in sacrum. 6th. At 8 a.m., 6 dr. in Oj of water. At 9 saliva was sour and saltish, but not unpleasant in taste, secretion increased. Between 9.15 and 10.45, some colicky pain . P.m. , sacral pain returned, better in active than in passive motion (driving), and better while up than when reclining, only that warmth of bed comforted it. Quiet sleep. 7th.-At 9.30 a.m. causeless depression ; sacral pain has extended into r. lumbar region. At 10.30 spirits revived. Two soft stools (unwonted) in d., as also on morrow . Acatarrh now came on, interrupting provings. On 24th, at 9 p.m., took 3 dr. of 15th dil. in Oj of water. Sleep often broken during n.; towards m. slight perspiration. Next m., increased secretion ofpleasanttasting saliva. At 8.15 repeated dose, and took 4 dr. on 26th, at same hour. Similar effect on saliva ; gum inflamed around r. incisors. On 30th 3 dr. No effect. On April 1st, 5 dr., and on 2nd, same. Persistent mental excitement (which has existed more or less for some d. past), with indisposition to mental exertion. Slight heartburn. On 5th, at 4 p.m., 4 dr. of 3rd dil. in water. From 6-8 p.m. dryness in throat. 6th. At 3 p.m. , same. At 3.15, momentary stitches in r. thoracic walls, and at 4.15 in chest and sacrum, especially on deep breathing. In n. , while lying on 1. side, fulness and oppression, as from stasis of blood in heart, necessitating turning to r. side. 7th.-At 2.30p.m., 6 dr. In 5 m. stitches with heat first in l. then in r. wrist. At 3.30 p.m. , 3 dr. undiluted. At 4, slight pressure in r. frontal eminence. 13th. At 2 p.m., 6 dr. of tinct. At 2.30, increased secretion of tasteless saliva. At 4.15, pressure in abdomen, 1. of navel ; compression at vertex ; cheerful temper. Next m. great weariness, but still unwonted cheerfulness. 24th.-In m. 5 dr. undiluted, without noteworthy effect. 29th. At 3 p.m., 14 dr. in water. Restless sleep during following n. 30th. At 3 p.m., 16 dr. Disturbed sleep again at n., with grave distressing dreams. May Ist.-At 6.15 a.m., 20 dr. in water. At 10, stitching pressure (momentary) in r. temple ; rumbling and colic in stomach ; urging to (copious) micturition. On May 26th there came all at once, with burning pain, a small ulcer at commissure of gum and upper lip, threatening to increase, but healing after a dose of K. bich. 3. Ten d. later pityriasis appeared on inner surface of1. thigh, opposite scrotum. (Ibid.) 13. Dr. KEIL, æt. 35, of phlegmatic-choleric temp., healthy, but liable to catarrh. (Took drops always in wineglassful of water.) a. Took 15th and 3rd dils. without effect. On Jan. 9th, 1854, a.m., 3 dr. of tinct. without symptoms. At 9.30 p.m., 6 dr.; unwontedly sound and deep sleep. 10th.-At 7 a.m., 9 dr. Soon after, passing sensations of pressure in stomach. At 11, slight dull headache anteriorly, which towards e. passes to back of head, and becomes drawing. During n. restless sleep with many dreams. Next m. some remaining dulness in head, which soon passed off. On 13th, at 9 a.m. , dr, At 2 p.m., urging to stool, with flying stitches across abdomen ;

pappy stool. 27th.-At 8.30 a.m., 30 dr. without effect, save feeling of heat in stomach for 1 h. at n. 31st.-At 9.30. a.m., 40 dr. Inh. slight pressure in stomach, passing into 1. side of belly ; after 1 h. repeated tasteless eructations. After 1 h. fulness in abdomen, feeling as if colic would come on, with slight rumbling, which soon passes into feeling of craving. On March 16th, at 3.30a.m. , 4 dr. Slight stitches in r. hypochondrium, I m. long ; soon after, pricking-drawing feeling in r.great toe (momentary) . 18th.-At 5 p.m.,6 dr. Some flatulence. At 10 p.m., same. 19th.-At 4 a.m., same. In forenoon faintness, feebleness, weakness in abdomen, towards noon passing into feeling of hunger. After 8 h. sudden stitching-drawing pain from r. buttock to perinæum form. 20th. At 8.15a.m , 12 dr.; at 4.45 p.m., same. Towards 5, slight throbbing sensation in rectum. At 6, same dose. Tongue feels spongy, and begins to coat over ; constant slight dragging in abdomen, as if colic would come on ; an insufficient evacuation in e., though much desire. At 10, same dose. Anxious dreams. 21st. -At 5.30 a.m., 12 dr. At 7, slight pinching in epigastrium. At 4 p.m., slight burning in abdomen below umbilicus and slight straining towards sacrum ; calls to stool, but stool is insufficient ; eructations and frequent expectoration of small quantities of mucus. In e. same dose. Stitches in l. lower jaw, sudden and transient ; pressure in l. side of abdomen, as if from incarcerated flatus, part being slightly sensitive to pressure . At 10 p.m., 20 dr. 22nd.-Was awakened at 2 p.m. by painful tympanites ; congestion to head without headache ; heat followed by sweat ; frequent pulse. Soon fell asleep again ; frequent passing of dark yellow urine, somewhat more copious than usual. At 6, some confusion in head ; heart's impulse almost imperceptible, but marked abdominal pulsation ; white coated tougue, spongy and pappy taste ; strong sense of hunger ; heavy feeling in sacrum, with one of obstruction in rectum. At times slow stitches in brain ; heaviness about eyes, as if hardly waked from sleep, with injected conjunctiva ; yawning, weariness, indisposition to work, stretching. At 9 a.m., 20 dr. At 4 p.m., feeling ofheat in rectum ; insufficient stool. 23rd.-No med. In m. moderate stool, nevertheless continued weight and fulness in abdomen ; pulse accelerated ; ebullition of blood ; in e. urine cloudy and mucous. 24th . At 8.30 a.m., 20 dr., and same at II . At 2 30 p.m. , flying stitches in l. great toe. At 5.30, 20 dr. Towards 6, fulness in chest, and again pulsation in abdomen, also perceptibly in vessels of neck ; pulse moderately quick. These sensations are specially marked when sitting still. A little later slight burning and drawing in epigastrium. Towards 10 p.m.,tickling infossa navicularis after micturition. 25th.-In m. bruised feeling in sacrum ; in n. broken and confused dreams . b. On April 14th, at 7 a.m., I took at one dose all that remained of my tinct., about 78 dr. In 1 h. flying stitches in brain, mostly under coronal suture; perceptible pulsations in head ; pulse abnormally frequent ; rumbling in abdomen ; in 1 h. stitches in l. thumb ; heat and dryness in mouth ; frequent yawning ; in 5 h. flying stitches in r. shoulder ; stitching pain below 1. jaw, recurring ; tensive feeling across over hypochondria. After dinner a somewhat soft stool, with

wind ; in 7 h . flying stitches in 1. ear, lasting a few m.; p.m. , rapid and sensible pulsation in carotids, also in head ; some tightness across chest, with desire for deep breathing ; dryness in mouth with thirst ; after 11 h. heat in sacrum extending to rectum ; flying stitches under 1. clavicle. ( Ibid.) 14. Dr. RÜCKERT, æt. 51, in good health save for remains of (second attack of) whooping-cough from previous summer. On Dec. 1st, 1852, in m., fasting, took 8 dr. of I, dil. in water, and at n. a X

similar dose. 2nd.--In m. feeling of pulsation in belly and chest, as of strong determination of blood from former to latter. Several times during d., but especially in e., after eating, feeling of ebullition in chest, and of working there as if something were alive in it. P.m., cold feet, shivering. 3rd.---This m. boiling feeling in chest returns . 4th.-Chest easy ; after food pressive pain in head, dissipated by a nap. (Ibid.) 15. a . E. R-, a girl of 20, brunette, health good save for some chronic conjunctival irritation. On Nov. 11th, 1853, took 4 dr. of I dil. in water in m. No change. 27th.-Same dose. At II a.m., pain in r. teeth, and at 3 p.m. same in l. ear, both transitory. 28th.- In m. , 8 dr. Towards noon great heat of face, and soon after eating headache over 1. eye, better in open air, but persistently troublesome in room ; towards e. very violent pressure over eye, with desire to shut it and to press on forehead ; it lasts throughout e., and increases at bedtime, with nausea. 29th. In m. in bed violent colic immediately on waking, with digging in bowels, thereupon a single diarrhœic stool. 30th.-In m., 8 dr. Well through d.; in e., violent stitches in ears, and after (cold) supper intense heat in r. cheek and eye with cold feet. In e. same dose. Sleep good. Dec. Ist. On awaking some abdominal pain and great heat of face. Took 8 dr.; digging in abdomen and some diarrhoea; p.m., great heat of face, but with warm feet. In e., 8 dr. 2nd.-In m., same dose. On 29th lips had cracked, unusual in such weather as then existed ; on Ist they were much fissured, and to-day can hardly be moved ; lower lip, from which hardened skin had peeled off, very painful. 3rd.-In m. same abdominal pain and (4 times) diarrhea. Colic lasted all d. On forenoon and e., pain behind 1. ear, as if glands were swollen. 4th.-Colic and diarrhea as before ; lips still painful and readily cracking. 5th.-Colic and diarrhea only immediately after rising ; so also on 6th, 7th, and 8th; pain only gradually disappearing after this. b. On Nov. 3rd and 4th, 1853, took 2-3 dr. of 12th dil. without effect. On 6th, 8 dr. On going to bed considerable palpitation, such as she has never experienced before. ( Ibid.) 16. Dr. TEICHMANN, æt. 36, in good health, save for some hæmorrhoidal troubles. Feb. 28th, 1857, at 7.30 a.m., 3 dr. of 15th dil. in water. March 2nd.-7 dr. at 7.30 a.m. 3rd.-Towards noon feeling of pressure in l. upper arm near elbow, which in course of afternoon became severe on moving shoulder, and especially on raising arm, so that he could not get on his coat. When quiet he felt nothing, and n . was painless and restful. During 4th and 5th this pain gradually subsided. On 7th, 5 dr. of 3rd, and on 8th, 5 dr. of tinct, without result,

On 15th, at 7 a.m., 7 drops of tinct. On 16th, awoke at 5.30 a.m. with pressure and discomfort over transverse colon ; fell asleep again in h.; on rising feeling had not quite gone, but was slighter. ( Ibid.) 17. Dr. BÖHLER found, both in himself and in several members of his family, though all little sensitive to medicine, that after almost every dose (3 dr.) of 15th dil., as also afterwards of 3rd, there occurred one or two loose, almost diarrheic stools, to which they were not at all subject. (The doses were taken in e., I h. before bedtime.) After 3 dr. of 3rd in e. there came in h. scraping dryness in throat, and tickling cough ; also slight drawings in upper jaw and orbital margin, soon passing off and alternating with irritation in throat. After 6 dr. immediately tingling sensation in tongue and throat. ( Ibid. ) 18. Dr. SYBEL took repeated doses of 15th, of I , and of tinct. up to 20 dr. 3 times a day, but without effect. ( Ibid.) 18. a. I held for 2 m. on the tip of my tongue a slice of the fresh juicy root, slightly bruised. Tongue became heavy, later stiff, last numbed, so that for 6 h. it was almost entirely insensible. Without any remedial means tongue then regained first its mobility and then its sensibility. b. Three gr. of same were infused for 1 h. in S-'s accustomed wine (4 oz.), and the whole (filtered) drunk by mouthfuls. It seemed slightly harsh and astringent, and produced tickling in larynx, and a little short dry cough, without any gastric disturbance. But a few m. later I felt burning in the urinary passages, followed soon by abundant flow of pale urine. c. Two h. after mid-day meal I swallowed nearly I gr. of same in breadcrumb. After h. there ensued burning in stomach at a fixed point, flying pains in head, and chill coursing along spine. Burning lasted 1 h., and spread all up sternum, then into abdomen, shifting from place to place, getting more acute, and assuming character of colic. After 2 h. more I felt in lumbar region and along urinary passages a considerable irritation, accompanied with continual desire to micturate ; there passed, however, only a very small quantity of burning urine, with strangury. Soon after followed very painful rectal tenesmus, with a small stool, after which came a quantity of transparent, yellowish, skinny mucus,with some slight tormina. Urinary irritation persisted ; there was also great epigastric tension, violent pains in head, some attempts at hiccup. Pulse was very excited, appetite nil, thirst lively. A drink containing lemon-juice was now taken frequently ; some stools followed, and after a few h. great relief to all save urinary symptoms, which last continued even through n. Next m. I felt weak, free from gastro-enteric pain, but micturition continued difficult and excited frequent and painful urgings to defæcate. Head was heavy, but without pain ; slight burning remained behind sternum. A demulcent drink was now taken, after which urine flowed freely, changing from fiery- red to brown, then green, lastly pale. Appetite did not return this d. On 3rd d. only some debility and short lancinating pains in joints. Next d. quite well. (STÖRCK, Lib. de Stramonio, &c., 1762.) 19. a. March 19th, 15 dr. tinct. 6 times a d. Transient headache in e.-20th. 15 dr. 7 times a day. All d. weak and weary, all right in e.

b. After taking for several d. from 15 to 30 dr. several times a d., took on April 2nd, at 7 a.m., 45 dr. all at once. No relish for breakfast ; some rumbling in bowels and urging to stool, which was watery, slimy, of blackish-brown serpentine colour and fæculent, smelling like fresh bile or blood after standing for a few m. in the water-bath. After I h., and at I p.m., stools of same character, after the last quite exhausted, lazy, sleepy, limbs prostrated, no inclination for work. Sense of smell very much exalted, strong-smelling things extremely repugnant. Tongue rather furred, appetite diminished, thirst increased. After dinner slight nausea, was very cross, and slept very restlessly for near 20 m. , but unrefreshed by the siesta. Chilliness all d. till 7 p.m. At 7.30 p.m. , ate pretty much as usual. After supper much more lively. Urging to stool still but slighter, and some rumbling in bowels. Another stool at 11 p.m., and next d. 2 loose stools. (BÖCKER, Beitr. , ii, 204.) 20. The following additional symptoms were observed whilst and after taking tinct. May 3rd, 11.50 a.m., gnawing in belly that soon went off. After supper walked slowly for h. and perspired considerably. Lay awake for 24 h. in bed. All n. slight perspiration.- 4th . No symptoms except a loose stool in e.-5th. Slept well, perspired moderately. When visiting patients perspired, was rather tired, and on coming home perspired profusely. After dinner at I p.m. felt cold ; 2.45 p.m., a copious loose yellow stool, thereafter some pain with rumbling and feeling of movement in abdomen ; this went off, but recurred later with urging to stool without result ; stool at II p.m., watery and frothy, without pain. Appetite good.-6th, 10 a.m., painless movement in bowels for some seconds ; then it went off and returned everyth. Perspiration in m., not in afternoon. 4 p.m., rumbling and discharge of flatus. After supper full feeling in abdomen, relieved by a copicus pappy stool at 10 p.m. Afterwards movements in bowels. Perspired at n.-7th, 8.30, thin stool. 4 p.m., rumbling in bowels, and thin yellow stool ejected with violence ; during and after it a transient uncomfortable almost painful feeling in abdomen. Both a.m. and p.m. moderate perspiration. While walking, 5 p.m. , perspired considerably. 11 p.m., a copious loose stool.-8th, m., rather tired ; this went off after getting up. Slight pain in abdomen. After siesta more tired and lazy than usual. 4.30 p.m., urging to stool, slight discomfort in bowels. 5 p.m., thin loose stool. 9th, 10 m. before taking med., feeling of movement in abdomen followed by stool, at first normally consistent, later loose. 2 p.m., movement in bowels recurred and lasted till e.; at 11 a loose stool.- 10th. Soon after taking med. slight rumbling and movement in bowels lasting all m. (Ibid., p. 220.) 21. A man, æt. 26, blond, sanguine temp., took 20 dr. tinct. of seeds. Immediately, numbness of whole buccal cavity, especially tip of tongue, with loathing and nausea. Increased flow of saliva, burning in mouth and all down œsophagus. Teeth felt on edge, with drawing pain from apices of upper teeth to maxillary bones. In stomach feeling of increased warmth and fulness. After h. slight irritation to sneeze through whole nasal cavity. Salivation continues. Confusion of head

with slight vertigo. Eructation, slight constriction of œsophagus. Feeling in both cheeks as if they were torn asunder. Pain at top of crown, like boring into head, the painful spot changes to different parts of sagittal suture. From nape up over occiput and in ears a dull drawing pain. After h ., pressure and discomfort in stomach, contraction in stomach. After 1 h., salivation still continued, the tooth- and headache, the pressure and warm feeling in stomach increased, especially towards r. side. In abdomen some rumbling, retching, and eructation. A disagreeable feeling in stomach which goes back to spine. Pressure and tearing in nasal cavity, pressure in nasal bones, feeling of commencing coryza in nose. After 2 h. , tearing in flexor aspect of all 1. forearm into elbow-joint. Paralysed feeling in all l. arm , drawing from 1. thumb along radial aspect of forearm. Cold and furry feeling in fingers ; tearing in r. shoulder and forearm. On both forearms on their ulnar side itching of skin, with redness of skin there. After 5 h., feeling of weariness of whole body, feet tired and weak. After 7 h ., slight tearing in r. hip-joint through thigh into knee, drawing on both calves and front part of r. foot. After 8 h., ordinary stool followed by rumbling in bowels and pressure in stomach. After 1 h. more, a soft stool with slight tenesmus. On urinating burning all through urethra and slight contraction of neck of bladder. Dull pressure on both sides of lumbar vertebræ. In 1. side of chest spasmodic compression and dyspnea for a few seconds. b. A few d. afterwards he took at 10 a.m. 15 dr. Immediately, copious flow of saliva, burning in esophagus and stomach. After 20 m., eructation, teeth on edge as if from eating much fruit, teeth seem too long, pain in them from apices of upper teeth into upper maxilla. After h., constriction of œsophagus, pressure and discomfort in stomach, gums painful, dull pressure in occiput, feeling as if scalp from behind and before were drawn up in the middle of vertex, where there is a small painful spot as if the vertex were bored into. After 2 h., creeping in nose, pressure in nasal and facial bones, jerking tearing in temples. After 24 h., twitching in all limbs as from electric shocks , especially in joints of 1. metatarsus, great prostration and weakness, disinclination for mental work. Inn. between 2nd and 3rd d. very restless and fatiguing sleep. On waking in m. great nausea and rumbling in bowels with painful contraction and pinching. Stool and urging with feeling of diarrhea. On rising up in bed the symptoms always increased ; after rising the nausea increases to vomiting of a little bilious bitter fluid, followed by soft stool with much urging and little evacuation. Better in open air, but the nausea and rumbling continue. Towards e. of 3rd d. nausea and rumbling return for about 2 h. In e. fine but tiresome pain in whole frontal region, especially above eyebrows , extending to dorsum of nose. Soon afterwards feeling as if r. eye were compressed, for a few seconds only, but frequently recurring. 4th d., in m., frequent transient anxiety in chest, pressure on parts, especially in 1. side of chest, short stitches which begin in anterior thoracic wall and seem to go out at posterior wall ; feeling as if sternum and spine were screwed together ; from apex of 1. scapula to spine a tense pain increased by moving arm. At noon stiffness in 1.

thigh, making walking difficult ; in bed, n., r. knee painful for a short time with feeling of lameness. 6th d., though he had never before had rheumatism, he got rheumatism in nape, the r. cuccularis in its whole extent so painful that he must cry out when he moves the neck ; the worst pains went off after 2 d., but the movements of the neck were not quite free for 4 weeks. (UNSIN, A. h. Z., lii, 82.) 22. A man, æt. 25, strong and stout, took Nov. 25th, at 8.45, 10 dr. tinct. of seeds. No effect.-26th, 8 a.m., 16 dr. The only effect till the 29th was 2 stools instead of the usual I daily. -29th, 8 a.m., 24 dr. No effect.-30th, 2 p.m., transient drawing-boring pains in middle of sternum towards 1. nipple, also here and there in r. side of chest, but chiefly in 1. side ; the pains relieved during deep inspiration . Later, feeling of tightness all over chest, as if a heavy weight lay in it. 5 p.m. , discharge of very fetid flatus, urging to stool, followed in h. by loose stool, with cessation of chest pains but persistence oftightness. -Dec. 2nd, 6.30 a.m., 30 dr. 8 a.m., great uneasiness in abdomen, considerable rumbling and urging to stool. 9 a.m., easy liquid stool without pain, and with relief of uneasiness in bowels. Feeling of emptiness and sinking in stomach, also after breakfast. Io a.m. , jerking tearing from r. elbow to wrist, often repeated, but only momentary ; later, the same pain from wrist to finger-joints. Noon, no appetite. The above pains in chest recur, are more severe, and last longer.-3rd . Tearing returns, chest tight, sometimes boring pains in 1. side of chest.-4th, 10 p.m., in bed, pains became so violent, and tightness so great, that he had difficulty of breathing and anxiety. Frequent constriction of chest, shooting and boring pains in whole chest, worst below 1. nipple.-5th. Appetite returned ; chest better but not quite free ; pinching pains in abdomen. The chest symptoms lasted a long time, sometimes better, sometimes more severe ; they only finally 23.ceased at thegirl, A strong end æt. of a 20, fortnight. ( Ibid., phlegmatic, 89.)5 dr. tinct. After took 5 m., eructations and feeling of flying heat in hands and feet with tearing through whole 1. foot ; toothache, teeth seem too long ; pressive pain in frontal region ; stitches in l. side of chest about 8th rib ; feeling of weakness and prostration in limbs ; deep shooting above 1. eyebrow, it seems to be drawn up ; arms heavy ; constant drawing in hands to fingers ; her hands seem so powerless that she thinks she must let even light things which she lifts fall out ofthem ; stomach full as though she had eaten too much ; great roaring in r. ear ; tearing in head, especially forehead ; tearing in arms with very paralytic feeling ; tearing in legs as though they were lame ; stitches in l. cheek ; pressure in frontal region as though all would come out there ; pinching in belly ; after I h. a normal stool. In e. epistaxis, next d. several loose stools without pain. (Ibid., 90.) 24. B- took on April 15th, 10 a.m., I dr. tinct., which caused heaviness of tongue, increased flow of saliva, feeling of enlargement of tongue, he would like to extrude it over the teeth ; p.m., great thirst.- 16th, 7 a.m., 2 dr. Bitter taste, drawing and cold feeling in lower incisors . I p.m. , stool followed by tenesmus.- 18th. 2 dr., coffee aggravates ; p.m., slimy stool with fatiguing pressure and straining ; sleep

restless, unrefreshing, limbs in m. as if fatigued ; later, pressive pain in r. then in l. frontal region ; dryness of eyes.-20th, 7 a.m., 5 dr. After h. eructation with burning in stomach . (Ibid. , 90. ) 25. After taking the extract and tinct. of colch. the following symptoms were observed :-Immediately after each dose the mouth became filled with saliva of a flat taste that provoked nausea, the mucous membranes secreted a viscid substance, and there occurred eructations seldom accompanied by vomiting and diarrhea ; there was a general feeling of malaise, slight attacks of colic and flatulence. After this state had lasted 2 h. there was sleep for 1 or 2 h. After 5 to 6 h. this sickness ceased, but instead there was great feeling of emptiness in head, with confused ideas, difficulty of thinking, and intoxicated feeling ; objects appear to whirl round and to have an altered colour ; roaring in ears, every noise causes disagreeable sensations with involuntary starting ; all parts of the body experience a prickling discomfort ; the breathing is difficult, often some palpitation ofheart, pulse sometimes slow, sometimes quick, but always small and weak ; colic, the attacks of which are very severe but generally without stool. After 12 to 15 h. the cerebral symptoms decline, but the eructation recommences, vomiting often ensues, chiefly of mucus, seldom of bile ; the abdomen is sometimes distended, the attacks of colic increase ; anxiety and dyspnea continue, there is sometimes general dry heat, sometimes more or less profuse sweat ; urging to urinate more frequent. The colic is chiefly in colon and is accompanied by pains in lumbar region and a feeling of pressure about pelvis. Then stools commence, at first of usual appearance, then soft, yellowish, ofpitch-like stickiness, with a peculiar fetid odour ; they cause heat of anus, then pain, and then the most tiresome tenesmus ; later they diminish in frequency, become watery and colourless. If the dose was rather large the bladder becomes involved, the urging to urinate increases, symptoms resembling those caused by cantharides come on, the urine has often a muddy sediment consisting of the epithelium of the vesical m.m. All the pelvic organs are in an irritated state, especially the genitals ; erections and even very exhausting seminal emissions occur. The last symptoms observed are general intolerable itching, especially around large joints, great prominence of the cutaneous papillæ, easy detachment of epidermis which makes the whole integument dry and rough, and disappearance of these symptoms after profuse fetid perspiration. (These last symptoms Goupil does not consider as the effect ofthe colch.; why, he does not say.) After large doses, e.g. 9 grammes ofthe tinct. in 6 doses at 2 h. interval, the symptoms do not occur so regularly. About 1 h. after the ingestion there occurs vomiting of mucus, seldom of bile, every h. for 24 to 48 h. The cerebral functions are quite disturbed, there is extreme empty feeling in head, confused ideas, difficulty of thinking, and painful intoxicated feeling; an object cannot be looked at fixedly without causing vertigo, all objects seem to whirl round and change colour, they generally appear yellow and sometimes with iridescent borders. The hearing is affected, sometimes there is roaring in ears, sometimes the hearing is extremely acute ; every movement of the head causes inclination to vomit and faintness. General malaise, accompanied by

formication all over the body, breathing short and difficult, often palpitation of heart and intermitting pulse. After 12 to 15 h. the mouth is filled with bad-tasting saliva, the eructations increase and are often followed by vomiting of a viscid, tasteless fluid. Dry heat of skin, after more or less profuse sweat. The most dangerous symptoms are : -The patient cannot think connectedly, he has confused sensations, all objects whirl round him in a chaotic manner, he does not move his head for fear of vomiting or fainting ; hallucinations of the strangest sort fatigue his sight ; the most extraordinary noises distress his ears . At the same time the attacks of colic are often but slight, sometimes severe, attended with spasms ; the perspiration is clammy and cold. These symptoms cease after stools, but then the pains in the pelvic organs become most severe. (GOUPIL, Froriep's Not., 1861 , iv, 18.) 26. a. A man, æt. 30, with a slight chronic eczematous eruption, was placed on a regulated diet and the urine carefully collected. Before taking colchicum : Oct. 30th ... Urine 56 fl. oz.; sp. gr. 1016. Uric acid in 24 h. 8.73 gr . ‫رو‬ 31st ... ‫د‬ 64 ‫دو‬ ‫دو‬ 1014 ‫دو‬ ‫دو‬ 7.9 " Nov. Ist ... ‫دو‬ 84 ‫دو‬ " 1012 ‫د‬ ‫د‬ 8.09 "

" 3rd ... ‫دو‬ 66 " " 1016 ‫دو‬ " 8.18 ‫دو‬

Average = 68.5 8.24 Whentaking colchicum : Nov. 4th Urine 56 fl. oz.; sp. gr. 1015. Uric acid in 24 h. 6.05 gr. ...

" 5th ... " 56 " " 1016 ‫د‬ ‫دو‬ 8.51 ‫د‬

‫ני‬ 6th " 46 " " 1020 " ‫دو‬ 8.00 ‫دو‬ " 7th ... ‫دو‬ 56 ‫دو‬ " 1016 " " 6.61 "

9th ... ‫دو‬ 54 ‫د‬ 1021 ‫دو‬ ‫ود‬ 9.18 "

Average = 55.6 7.67 b. Another man, æt. 19, with chronic elephantiasis of upper lip and pretty good general health, was treated in same manner. Before taking colchicum : Jan. 13th, 1854,urine 55 fl. oz.; sp. gr. 1017. Uric acid in 24 h. 7.91 gr. ‫د‬ 14th " ‫د‬ 28 ‫ود‬ " 1027 " 4.48 ‫د‬

" 15th ‫دو‬ " 30 " ‫י‬ " 1027 " " 3.00 ,

Average = 37.7 5.03 When taking colchicum (3ss ter die. ) : Jan. 16th ... Urine 47 fl.oz.; sp. gr. 1015. Uric acid in 24 h. 1.34 gr. ‫دو‬ 18th ... ‫دو‬ 23 ‫دو‬ ‫دو‬ 1024 ‫دو‬ ‫دو‬ 755 ,, " 19th ... ‫دو‬ 24 ‫دو‬ ‫دو‬ 1025 ‫دو‬ ‫دو‬ 7.24 , ‫دو‬ 20th ... ‫دو‬ 13 ‫دو‬ " 1031 ‫دو‬ ‫دو‬ 5:00 ,, ‫دو‬ 22nd ... ‫دو‬ 19 ‫دو‬ ‫دو‬ 1027 ‫دو‬ ‫دو‬ 5°34 ,

Average = 25.2 5.29 C. was taken ter die for 2 d.; on occurrence of purging I dose omitted, 2 doses kept up free action of bowels. General results : ( 1) There is no evidence that C. produces any effects by causing increased elimination of uric acid, but if continued for a lengthened time it appears

to exert a contrary effect. (2) It does not influence amount of urea or other solids of the urine. (3) It does not always act as a diuretic, but has a contrary effect when it produces a marked effect on the alimentary canal. (GARROD, On Gout, 3rd ed. , pp. 324, 333. ) 27. Experiments on a healthy man, æt. 28. Urine for 3 d. previously was of following average character, viz. :-Quantity 1230 c.c., sp. gr. 1025.08, solids 63.12 grms. (inorganic matter 29.83, organic 33.29), strongly acid. Took ziss officinal tinct. of C. 3 times in 24 h. for 3 d. Ist d.-Urine :-Quantity 1595.7 c.c., sp. gr. 1024.37, solids 77.29 grms. (inorganic 36.50, organic 40.79), strongly acid. 2nd d.-Urine :-Quantity 1484.1 c.c., sp. gr. 1024 31 , solids 75 22 grms. (inorganic 35.01, organic 40.21), strongly acid. 3rd d.- Urine : -Quantity 1620 c.c., sp. gr. 1022.06, solids 79.33 grms. (inorganic 34.20, organic 45.13), strongly acid. Average in health and under colchicum : - Normal. Quantity 12800, sp. gr. 1025.08, total solids 63.12 (inorganic, 29.83, organic 33.29) . Colchicum. Quantity 1556.6, sp. gr. 1023.58, total solids 77.28 (inorganic 35.23, organic 42:04). (W. A. HAMMOND, M.D., Amer. Fourn. Med. Sciences, xxxvii, 277.) 28. R. H-, æt. 18, student of medicine, suffering from slight sore-throat, took 50 dr. vin. colch. at 9 a.m. At 12.30, no effect ; took 30 more. At 7.45 p.m. 20 more. At 11.15, slight nausea. At8.30 a.m. next d. took 60 dr. more. Breakfasted sparingly, appetite impaired. At 9.30 sudden copious stool, with considerable griping pain ; 15 m. afterwards he experienced in large intestines feeling ofgreat commotion, which was immediately followed by 6 very copious yellow watery stools. A feeling of weakness continued for 24 or 48 h. (LEWINS , Ed. Med. and Surg. Journ., xlvii, 348. ) 29. W. F-, æt. 17, student of medicine, in perfect health, took 70 dr. of vinum at 7 a.m. and 30 more at 10.30. Slight nausea at 11.30. At 12.30 took 30 dr. more. Nausea increased. In 3 h. after he took 40 dr. more. Severe sickness occurred in 2 h. after this dose, followed by a copious stool . At 9 p.m. another stool. Slept well , but on waking at 7 a.m. felt sick and faint. Had yellow watery stools during d. A little after 8 a.m. vomited more than a quart of thick whitish matter, had some desire for food but could not eat. At II a.m. vomited viscid greenish matter, and soon afterwards vomited again. At 3 p.m. rejected brandy and water which had been taken, and at 4 p.m. vomited again. Next m. felt sick and could not eat, sickness subsided during d. Urine of deeper colour than usual and deposited a sediment. (Ibid.) 30. J. H-, æt. 15, took 40 dr. of vinum at 9 a.m. and 30 more at 12 a.m. In 2 h. he felt squeamish. At 4 p.m. took 30 dr. more, and had more nausea in h . At 7 p.m. 30 dr. more were taken, soon followed by severe sickness. Vomited 3 times at 10 p.m., and soon after on taking food it was instantly rejected. Bowels were moved once. Slept well ; slight nausea next m. Quite well at dinner time. (Ibid.) 31. F. L-, æt. 12, took 30 dr. of vinum at 9.30 a.m., 30 more

at 5 p.m. At 8 p.m. felt sick and vomited copiously and easily. Then took an egg and slept well. At 6.45 a.m. next d. had a copious stool, soon repeated, and before e. 9 watery stools occurred without pain. (Ibid.) 32. a. J. B-, æt. 17, in perfect health, took 40 dr. at 8 p.m., and 30 more at 8 a.m. next d. Slight nausea in forenoon. At 3 p.m. took 30 dr. more. Bowels moved at 6 p.m., slight vomiting during e. several times, and once he fainted after a copious stool ; 5 stools before bedtime ; slept well ; was well at noon next d. b. Same 10 d. afterwards took 70 dr. at 6 p.m. and became sick in n. At I a.m. very sick, vomited bile ; much nausea, with occasional vomiting until 4 p.m. Upwards of a pint of bile was ejected between I and 9 a.m.; headache in course of d., ate little dinner, could taste tea at 7 p.m. Perfectly well next d. Pulse feeble during first 24 h . and below normal standard. It afterwards rose to 100, and there was feeling of debility. ( Ibid.) 33. R. B-, æt. 10, took 20 dr. at 10 a.m., and at 4.30 15 more. Next. m. 2 stools, no nausea. At 11.30 25 dr., and at 4.30 20 more were taken. An h. later bowels moved, and twice again between 6 and 7 o'clock, at which time he vomited. Nausea and vomiting, not violent, continued all e., also twice in n. (viscid bile), and had 3 more stoolsin all 9 operations. Nausea continued 15 h. Slept pretty well, though sick and awake in n. Little desire for food until next d., and not inclined to get out of bed. Pulse during continuance of nausea was feeble and less frequent than natural. (Ibid.) II. Poisonings.- 1 . A boy, æt. 6, after eating about 5 or 6 oz. of colch. seeds and capsules when playing in a meadow, complained on returning home, e., of headache, pains in r. wrist and throat. Then there came on a scarlet rash all over body, trembling of limbs that went on to an attack of violent convulsions about 8 h. after taking the drug. The convulsions lasted h. and quiet sleep ensued ; 3 h. later the convulsions were renewed in the same way, and ended in vomiting of 3 or 4 oz. of chewed, dirty green vegetable matter and I to 1 oz. green fluid. Next m., 15 h. after poisoning, he was very restless, complained ofpains in forearms which were very sensitive to the slightest touch ; skin leaden coloured, dry, hot ; nose, cheeks, and soles cold ; pupils dilated, consciousness oppressed ; pulse not to be felt, several h. later threadlike, trembling ; hardness of hearing, carphologia, unconscious urination, paralysis of r. legand 1. arm, head fell backwards. An emetic brought away seeds and pods of colch. The 3rd and 4th d. there were carphologia, grinding ofteeth, unequal breathing, involuntary passage of stools and urine ; but he heard better, the temperature of skin was more natural, and the skin a better colour ; increased strength and diminished rapidity of pulse, pupils less dilated. On 5th and 6th d., 1. sclerotic slightly reddened ; on cornea a sharply defined white spot, in anterior chamber some purulent fluid deposited, a capsular cataract commencing. Energetic treatment and tranquil sleep during n. brought some improvement . On 7th and 8th d. the purulent effusion in anterior chamber was diminished, the sclerotic less inflamed, the spot on cornea gone. But the 1. elbow and knee-joint were swollen, hot, painful, the r. side

half paralysed and nearly insensible, hearing again gone, grinding of teeth, tongue covered with thick, brown, dirty coating ; thirst increased. After a long sleep in the n. of the 9th there was a recurrence of the gastric symptoms, the fever, arthritis, and sclerotitis. But the r. side was completely paralysed and its sensibility very small, only the toes were drawn inwards towards soles when touched ever so slightly ; spinal paralysis, the head fell backwards when the child was raised, the mouth was drawn wide open. Pulse 190. The cornea appeared very convex and pointed, as ifby the enlarged opaque lens being pushed forward towards iris and pupil. On toth d., m. and noon, there occurred convulsions of 1. side and facial muscles for 15 to 20 m.; grinding of teeth lasted all d. with short intervals ; both eyes were always directed towards the sun's light, temperature of skin diminished, pulse 180. The swelling of elbow and knee gone, the eye seemed to be better. Same report for 11th d. On 12th d. the hearing and sight improved, he could support his head and muttered some incomprehensible sounds. L. thumb turned inwards, urinary secretion much increased. Pulse from 185 to 190. L. eye had almost regained its normal state, only there was dimness ofpupil. On shutting and quickly opening lids a yellowish flocculent membrane continually flickered round the edge of the pupil, which was of normal size, but dilated sluggishly and contracted quickly. On 13th could drink water but could eatnothing but sugar. Teeth and tongue again covered with brown sordes, sclerotic again red. The membrane in the l. eye had fixed itself immovably in anterior chamber ; it appeared about 2 " long and "" wide. In posterior chamber the lens was perceived opaque but smallerthan before, the brown iris dim and obliterated, the pupils extremely sensitive to light ; this symptom declined the following d. The membrane had fallen to the bottom ofthe anterior chamber. The lens had a greenish hue. The 15th d. the boy ate some cake and drank 2 cups of coffee which caused vomiting. Butthegrinding ofteeth which had diminished again returned. The sclerotic was less red, the membrane absorbed, the iris had recovered its dark brown colour, its excessive sensitiveness was gone. The lens had the colour of verdigris. Pulse small, hard, 180 to 185. Much diabetic (? ) urine was passed every 4 h. The next 9 d. the state remained unaltered, but he could take nothing but a few spoonfuls of coffee ; milk was vomited. He grew extremely thin. On the 25th d. the greencoloured lens seemed to have receded more into the depths of the chamber. 26th d., there was only some cloudiness towards inner angle, which was gone by the 28th. On 29th grinding of teeth returned with convulsions of 1. side and of both eyes. Tongue white, skin hot and dry, r. arm lay motionless on chest, the thumb turned in, the other fingers tightly closed over it. Consciousness gone. The 30th d. he drank a glass of wine sweetened with sugar and some coffee without vomiting. On 32nd d. vomited everything he took, arms and legs and fingers spasmodically contracted. L. hand trembled. Eyes rolled convulsively. Abdomen felt doughy, not distended, but painful on slight pressure. L. sclerotic again red, and in bottom of posterior chamber a slight cloudiness which seemed to belong to vitreous ; 1. pupil contracted, r. dilated, both lids wide open. Pulse thready, 190 VOL . II . 22

to 195, strong palpitation of heart. Till the 44th day the breathing was irregular, the convulsions more frequent, spreading over cervical and facial muscles ; lower jaw firmly pressed against upper. Foam at mouth. These symptoms went off during next m., but the r. eye turned incessantly in a semicircle, while the l. eye was always in slight convulsive movements directed towards inner canthus. Both were little sensitive to light, l. iris again discoloured, r. pupil moderately dilated, 1. extremely contracted, the white spot again in the cornea, but the inflammatory redness of sclerotic gone. Nostrils dry and blackish. Cheeks and chin alternately leaden coloured and bright red ; face covered with sweat, breathing easy and uniform ; skin very dry, abdomen doughy ; r. arm could not be extended, 1. arm could not be flexed, both feet drawn up, the soles in form of semicircle, the toes spasmodically drawn towards soles. The body extremely emaciated, pulse and heart's beats scarcely to be felt ; each d. the same quantity of diabetic urine passed, and the bowels were moved. The spot on cornea gone on 49th d. On 50th d. the most violent convulsions of all parts of the body, except the paralysed r. side, came on. The spine was much affected. The head was bent backwards, the spine forwards, the abdominal muscles were drawn up, the abdominal integuments drawn tightly against lumbar vertebræ. At 3 p.m. death ensued. (SCHILLING, Heidelberg Med. Ann., 1840, vi, 591.) 2. A workman took at 7 p.m., Oct. 31st, I oz. oftinct. sem. colch . (from about drachm of seeds). After 5 h. oppression and violent pressure in scrob. cordis, feeling of constriction in chest, dyspnea, great burning in mouth, difficulty of swallowing, alternate heats and chills , anxiety, violent vomiting and diarrhea. He was 18 h. without medical aid, except that he drank in the m. chamomile and elder-flower tea without relief.-Nov. Ist, 1 p.m., he lay in bed, countenance sunken, pale, anxious expression, eyes surrounded by deep-blue circles, pupils contracted, swallowing difficult, with pain along œsophagus, tongue moist, furred yellow. No tenderness of abdomen. Pressure on it caused difficulty of breathing and increased anxiety. The vomiting continued violently, and brought up much yellowish-green water (probably the teas he had drunk) . The diarrheic stools had a very bad odour, they were orange-yellow slimy fluid, with many large bright yellow flakes, no fæces. Unquenchable thirst, desire for cold drink, cold skin, coldness of extremities, contracted spasmodic pulse, 80. He was treated as a case of cholera with emollient and narcotic medicines, he having concealed the cause ofhis malady. At 10 p.m. he confessed what he had done. He then got vinegar and water, and the other medicines were continued. His symptoms after this were not purely attributable to the colch. He gradually sank. A curious symptom was great pain in the heels which lasted till his death. He remained conscious till death, which occurred after 39 h. (Med. Zeit. v. Ver. f. Heilk. in Preussen, 1834, No. 29.) 3. A man, æt. 52, took at 9 p.m. by mistake for a cough mixture a decoction of a big tablespoonful of seeds. After h. felt rumbling and griping in bowels ; some diarrhea alternately with vomiting repeated about 15 times. Next d., at 8.30 a.m., the doctor found him

in bed, countenance not altered, quiet, but rather anxious. The vomiting and diarrhea were gone, felt very weak ; when touched the stomach is spasmodically contracted, pulse small, rather quick. Stools have a very fetid odour, are rather watery, and contain white flakes. He got warm water and butter, which caused a recurrence of the vomiting and diarrhea. He then got coffee and decoction of marshmallows with lemon-juice. He felt pretty well after this. But next d. he looked pale, breathing hurried, he coughed and groaned, voice hoarse, eyes lay deep in head, pupils very dilated, frontal headache. The tongue protruded with difficulty, it was covered with white fur, gastric region painful, face and extremities cold, pulse quick and scarcely to be felt. Stools contain some bright blue matter. Mind confused, paralysis set in, followed by death. P.M., 23 h. after death, showed great stiffness of all limbs and muscles, the muscles of a dark brown colour. On abdomen peculiar spots, increasing on both sides towards back, of violet colour with a shade of green, not circumscribed, but shaded off and of a streaky character. Inflammation at the junction of bronchi with trachea. Lungs normal. Little fluid in pericardium. On upper and posterior part of heart large black, violet and blue spots, in the shape ofclouds. In heart's cavities much coagulated blood like waggon-grease. Inflammation of œsophagus after passing through diaphragm,very distinct inflammation about cardia, which was of a dark violet brown colour. Peritoneal covering of stomach bright violet, its m.m. dark violet, its veins congested with black blood ; the liver on its under surface, especially towards stomach, was violet. Mesenteric veins full of black blood. Small and large intestines showed reddish-brown colour of their m.m. (NEUBRANDT, Würt. med. Corresp ., x, No. 3.) 4. A child, æt. 24, ate some seeds ; seen next d. The doctor learned that the previous e. there was vomiting and watery diarrhea, with occasional slight stupefaction. The following n. the child was running about in the room, and not till 11 a.m. did the toxic symptoms occur. The child was pale, sat on its mother's knee with wideopen eyes and stony look, bluish lips, dilated pupils, white tongue, very distended abdomen, hot skin, quick pulse, great thirst, frequent watery stools, scanty urine, restless irritable humour,sometimes moaning. Put to bed it became immediately stupefied, but could be easily roused. Eyes distorted, sometimes slight twitchings in limbs. After an emetic of ipec. vomiting of a large quantity of curdled milk. After various medicines were given the vomiting ceased after a time, but the watery stools continued, and the child became comatose, and died 36 h. after taking the seeds. After death the abdomen was very much swollen . (BALLUF , Inaug. Diss., Tübingen, 1845.) 5. One drachm vin. sem. colch. daily caused great weakness, prostration, cold skin and tongue, diaphoresis, extreme thirst, contraction of chest, and dyspnoea. On 2nd d. eructation, violent pain in stomach, vomiting, increased biliary secretion, pinching in abdomen, copious yellow stools, violent diarrhea, yellow watery stools, profuse secretion of turbid urine, sp. gr. 1034 ; urine like chalk and water, caused by urate of ammonia. Next d. urine acid,

cramps in legs, pulse 170, weak and thready. ( Hufeland's Fourn. , Dec., 1841. ) 6. A man, æt. 60, who had suffered for 15 years from arthritis anomala, took in 1 h. 50 dr. tinct. sem. After 18 h. he felt in middle of forehead a fine pain, accompanied by peculiar excitement of cerebral nerves. His vision was unusually acute, but his intellectual powers were so weakened that he could not understand what he read. He could not speak intelligibly, and mistook one object for another. He had a difficulty in moving his tongue, which often refused to move. For a week he could not write in a connected manner, and frequently left out a syllable in the words he wrote ; his thinking power was much impaired . (Ibid., 1835, lxxv, 1 , 101.) 7. I found on my arrival at Fort Denaud in Florida a private in the Marine Corps labouring under symptoms not unlike those of Asiatic cholera. He had constant sero-mucous ejections and purgings, resembling rice-water, and thrown off with considerable force ; cramps of the abdominal muscles and of the flexors of arms and legs ; cold surface, tongue and breath ; mottled skin and bluish nails ; shrunken features expressive ofgreat agony ; sunken and watery eyes, with contracted pupils. I found that he had swallowed the d. before over a pint of vinum colchici, mistaking it for liquor. Death took place in 48 h. after ingestion. (MCPHAIL, Am. Med. Lib. and Intell. , 1839.) 8. A bottle of vinum colchici was drunk by 17 persons, 7 of whom died from effects, of which following is a résumé :-In from 45 m. to 1 h. after ingestion vomiting ensued. Contents of stomach were first rejected, then bile or mucus ; afterwards a fluid similar to " rice-water " ofcholera. When amount taken was great purging came on simultaneously with vomiting ; but if only a small quantity, comparatively speaking, had been swallowed, action of bowels was delayed for several h. Passages were first natural fæces, then bilious stools, then " ricewater " a very large amount of frothy, slimy secretion, compared by one patient to clean soap-suds. In no case was any blood to be found. Vomiting continued till last moments in fatal cases, and bowels were emptied involuntarily. Cramps were severe in stomach, bowels and legs . Severe pains were felt in knee-joints in some, and in 2 cases were very marked in 1. shoulder, so much so, indeed, as to be a continual cause of complaint, and to compel avoidance of lying on 1. side. Rubbing was frequently demanded for relief. In the majority there was numbness from elbow to wrist, cramps of fingers, especially 2nd ; in one extreme numbness of thumbs under nails, lasting 26 d. In a boy there was great pain between shoulders. Features ( h. after) were pinched and drawn ; lips and nose blue, as also lobes of ears . Eyes were congested, pupils slightly dilated ; voice hoarse and husky, pain experienced in speaking. Feet and legs icy cold, as also hands and arms ; rest of body had clammy feel, but was below normal temperature. Pulse rapid, 125-145, small, compressible, intermitting, and at times imperceptible at wrists, though it could be found at elbow with some trouble ; temporal arteries difficult of detection, even carotids required patience to distinguish. For several h. before death arteries were almost pulseless ; heart's impulse not to be felt, and its sounds

with difficulty heard on applying ear to chest wall. They might be likened to a blowing sound, to a murmur, or to a heart beating at a very great distance, or heard through a stone wall-both sounds melting into one. Respiration was full and easy, and well maintained throughout, as was also pulse-respiration ratio. The sufferers were sensible throughout and to the last. One case ended with a slight convulsive effort. All sat up before dying, falling back in an instant. No headache was complained of. Muscular strength was retained. They were all able to sit up, lift a cup to their lips, or even walk. They were perfectly sleepless. In 2 recoveries there appeared a pustular eruption on face and lower extremities. (MAJOR, Canada Med. and Surg. Journ. , 1880.) 9. Asomewhat corpulent woman of33, habits notstrictly temperate, took at II p.m. one Thursday nearly 3j of tinct. Within 3 h. she experienced severe pain in stomach, with vomiting, first offood, then of thick bile ; thereupon followed bilious diarrhea, stools growing thinner, and mixed with small white membranous fragments. This continued more or less all n. On Friday m. patient complained of numbness in feet and hands. To this succeeded a pricking feeling, as if (so she expressed it) they had been asleep. Alljoints of fingers and toes, and also wrists and ankles, were very painful, and toes and fingers were painfully flexed at times. Pain in shoulder-joints succeeded, and, on Saturday, in hips and loins. It was also increased in intensity, so that she said she thought she should go mad. Ultimately almost all the bones and joints were affected with pains, which were of a gnawing dragging character. Just before these symptoms were at their height, very profuse sweats came on, and were of a very sour odour. I may mention that to the pains in the joints were added, on Sunday morning, great stiffness and pain in back of neck and occiput, which was aggravated by moving head ; there was also a feeling as of something tightly bound round head; and on moving tongue and in swallowing she experienced sharp pain about root of tongue. She asked me if she had not got rheumatic fever. The pain in the joints continued exceedingly severe long after vomiting and purging had ceased ; it was still so on Tuesday. (HENDERSON, Lond. Med. Gaz ., 1838-9.) 10. Six persons drank from a bottle containing tinct. sem. colch. under the impression that it was brandy and bitters. Two soon died after vomiting and purging. a. A boy, æt. 15, was the followingday in 66 a paralysed state" but quite conscious. Brought to the hospital his symptoms were : cold extremities, pulse weak, between 80 and 90 ; appearance ofgreat suffering, face very pale, lips butslightly red, tongue normal. Abdomen fallen in, gastric region painful also to touch. Sensibility and motility normal. Expression of face showed great suffering, thighs drawn up, still inclined to vomit, great exhaustion, violent abdominal pains. Consciousness clear, pupils normal, n. very restless, repeated stool,no vomiting. Collapsed features, pulse scarcely to be felt or counted, quite cold extremities, sopor, death. P.M.- Sunken eyes, stomach filled with sour yellowish fluid, m.m. of cardia easily detached, gall-bladder full, bladder full of urine, vena cava ascendens filled with thick, dark, cherry-coloured blood, r. ventricle of

heart full and 1. ventricle partially filled with dark blood, also large blood-vessels, cerebral membranes distended with blood, also vessels of cerebrum and cerebellum, sinuses unusually full. b. A man, æt. 44, when admitted to hospital had marked paleness of face and of visible m.m., deep-lying dull eyes, expressive of great suffering, great collapse, temperature of skin diminished, skin feels moist and clammy like that of a cholera patient, pulse from 80 to 90, small and weak, abdomen flat, little pain when pressed strongly. Stools yellow, bloody, liquid ; at n. vomiting ofwhitish-grey fluid and several dysenteric stools. Next m. pulse 108, small, scarcely perceptible, irregular and intermitting, temperature of extremities lowered, abdomen slightly painful to pressure ; suppression of urine for 24 h., bladder not distended. No sleep, no appetite, much thirst, great prostration, headache all n.,perfect consciousness,died at 1.45 p.m. P.M.-Stomach filled with a sour fluid like curdled milk ; its blood-vessels full, kidneys congested, vena cava ascendens distended with thick, dark, cherrycoloured blood, heart distended with dark blood, cerebral membranes congested. c. P.M. ofman, æt. 30, who was not observed during life. Stomach shows network of blood-vessels, its inner surface scarlet red, is distended with a sour greenish fluid, gall-bladder empty, on outside of small intestines numerous rose-coloured spots. Kidneys unusually full ofblood, bladder contains about a tablespoonful of acid urine. Vena cava ascendens much distended with thick, cherry-red blood, r. ventricle full of dark blood, very little in l. ventricle. Cerebral membranes distended by blood, also substance of the brain, sinuses filled with dark blood. d. A boy, æt. 14. Eyes stand open, bluish lips ; small curvature of stomach with distended blood-vessels, stomach filled with acid fluid, m.m. pale, its posterior surface presenting small purple spots ; liver full of blood, gall-bladder full ; both kidneys much congested, bladder filled with acid urine ; vena cava ascendens filled with dark red blood, both ventricles of heart filled with dark blood, also great blood-vessels ; cerebral sinuses filled with blood, cerebrum very full of blood. ( Casper's Viertelj. f. gericht. Med., vii, 1, 1854.) III. Experiments on animals .-1 . a. 30 dr. of a vinous infusion of C. diluted in 3j of water was injected into the jugular vein of a moderately-sized dog. The pulse was 140 in its natural state. In 5 m. dog had tremulous motion of muscles with fluttering of pulse, accompanied with nausea. In 14 m. p. 180, with frequent intermissions. In 4 h. p. 120, of natural strength and frequent intermissions. In 7 h. a natural motion ; p. 140, no intermission. At end of 3 d. same dog swallowed 60 dr. of same infusion. In 2 h. he was languid, pulse wiry and weak, 140. In 4 h. less languor, p. natural. In 8 h . natural motion, in 11 h. well. b. Into the circulation of another dog 160 dr. of same infusion were injected. The animal instantly lost power of voluntary motion, respiration slow, and pulse hardly to be felt. In 10 m. pulse was 84; inspirations natural, 40. In 20 m. p. 60, inspirations 30, and a tremulous motion in hind legs. In I h. p. 115, irregular ; animal in state of violent tremor, inspirations could not be counted. In 1 h. tremor

gone ; p. same ; ineffectual attempts to vomit for 10 m., accompanied with great languor. Inspirations 54. In 2 h. p. 150, very weak ; 1 oz. urine voided, 2 liquid stools, and twice vomiting of a quantity of mucus tinged with bile. In 3 h. vomiting again, and another stool ; p. too weak to be counted. In 4h. very languid. In 5h. vomited bloody mucus and died. On opening body stomach contained mucus tinged with blood, surface of duodenum was universally inflamed, less so that of jejunum and ileum, but that of colon more so than that of ileum. (Sir E. HOME, Philos. Trans., 1816, pp. 259, 263.)

Volume II — Appendix

Colchicum.*-P. 329, 1. 20, for " S-'s " read " my." L. 28, for "chill " "

read " chills." L. 29, for " and " read " then," and for " then "thence." L. 36, "

for " yellowish, skinny " read "jelly-like." L. 39, for " lively " read " great.' L. 3 from bottom, for " Stramonio " read " Colchico," and for " 1762 " read " 1763." P. 341, 1., 11 , after " stools " read " and vomit." L. 12, for " This " read "Vomiting." L. 13, for " all n. " read " for 2 d." In reference for II. 9, add " II . 763." After II. 10, insert the following :- 11. A woman, æt. 25, on June 2nd, 7 p.m., drank 5 oz. of a tinct. made by macerating 2 roasted and pulverised roots of C. in a bottle, half of white wine and half ofbrandy. Immediately she had violent pains in stomach. After h. she got milk about 2 pints,thenanenema with 2 gr. tart. em,which causedviolentvomiting. At 1 a.m. she was found cold, pale, lying on back, gastric region very sensitive, abdominal integuments seemed hotter than rest ofbody, lips violet, eyes closed, pulse thready and very slow, breathing very laboured. She was perfectly conscious and said she wished to die; there were severe cramps ofthe soles. She constantlyvomited asmall quantity ofcolourless and inodorous fluid. She had previously vomited much brown fluid, evidently the poison. Sinapisms to soles, warm aromatic frictions on limbs, effervescent drinks.-3rd, 6 a.m., great prostration,heat in epigastrium less, hollow eyes, vomiting ceased, pulse increased in strength and rapidity,cramps in soles diminished. 3 p.m.,pulse could only be felt in carotids,consciousness intact; at 5 p.m. she died, 22 h. after taking the poison. P.M. after 72 h. Body very thin, eyes sunken, surrounded by dark rings ; liver, spleen and heart full of black blood. Stomach andbowels not examined. (CAFFE, Obs. d'empoisonnement par la teinture vineuse des bulbes de Colchique.) 12. Aman took, May 11th, 6 p.m., about 2 oz. of C. leaves. About midnight he felt ill, had colicky pains in bowels, inclination to vomit and actual vomiting, urging to stool and diarrhea. A surgeon gave a dose of opium and afterwards a powder ofRad. Ipec. 3ss, Tart. em. gr. ij, Sacch. alb. j, a small quantity every h. Thevomiting and purging were now so violent that nothing more could be given. Seenthe following d. at 9 p.m. his state was as follows :-Features distorted, the muscles supplied by nerv. facialis spasmodically affected causing risus sardonicus ; pupils verydilated, little affected by light; tongue moist, its root bluish; he was very patient and docile, contrary to his usual habit; rheumatic drawing in nape, some * These corrections failed to be made while printing was going on owing to the mislaying of a proof-sheet,

pressure in throat; burning feeling in plexus solaris; abdominal muscles spasmodically contracted; vomiting and watery diarrhea, but not so frequent ; occasional tenesmus ; temperature of skin much diminished; pulse slow, hard, tense, rather thready; urine suppressed ; cramp in fingers and calves.-13th, 3 a.m., delirium and carphologia. 7 a.m , staring, sunken, dull eyes; risus sardonicus ; tongue quite blue ; breath cold; difficult speech, extremities striped bluish black, pulse imperceptible, skin of extremities warm, of abdomen cold; suddenly spasmodic movements in muscles of nape and mouth, death. (BLEIFUSS, Med. Correspondenzb. d. Würtemb. Aerzt. Ver., ix, No. 52, 409 ; in Frank's Mag., ii, 69.) 13. Agirl, æt. 20, suffering from tumor albus genu sinistri took, June 4th, 10 a.m., from 4 to 5 oz. tinct. After a short time she had violent pains in epigastrium, repeated vomiting, stool only after enemata, feeling of tightness of chest, extreme dyspnœa, progressive coldness, very painful cramps in feet, especially 1., with very violent pain in diseased knee, pulse grew gradually smaller, contracted, intelligence undisturbed till death, which occurred 28 h. after the poison had been swallowed. P.M. 43 h. after death. Putrefaction had set in. Abdominal integuments and skin of nose green, rigor mortis very strong, sugillations over body and limbs. Vessels ofpia mater and cerebral substance greatly injected, especially in posteriorths of hemispheres, not in anterior fourth, which was softer than the rest of brain, of a green colour and putrid smell. Lungs normal, in both ventricles of heart black coagula with pale red diverticula among columnæ carneæ. Stomach much distended with gas and containing a few spoonfuls of greyish inodorous fluid, m.m. grey, softened and easily detached. Duodenum contained a little of the same liquid, its mucous glands the size of mustard seeds, in lower third of ileum violet-coloured plaques formed by agglomeration of mucous glands. Liver large, pale, olive coloured, soft. (OLLIVIER,Arch. gén. d. Méd., xli, pt. 4, 433 ; in Frank's Mag., iii, 138.) 14. A boy, æt. 4, May 27th, e., swallowed a quantity ofseeds. In n. hadviolent pain inbowels and frequent vomiting.- 28th, 1 p.m.,he lay in a state ofsopor on his back with half-shut eyes and audible rapid breathing, features sunken. Hippocratic, dull look, pupils slightly dilated, eyes staring, tongue bright red, its root covered with mucus. On touching abdomen he woke out of his sopor, but it immediately returned. Abdomen distended, tense and hard. The stools 12 h. after poisoning contained seeds of C. Passed a large amount ofurine, and had occasionally pains in calves and feet. Vomited food and pale green mucus, pulse small, contracted, skin dry, body hot, extremities cold, great exhaustion, general prostration, unquenchable thirst. After 20 h. gastritis had become developed. Leeches and demulcent drinks. 6 p.m , vomiting continues, hiccup ; sometimes transient excitement; extremities cold, face pale, forehead covered with clammy perspiration, a large quantity of urine passed, only one stool, breathing quick, sobbing, pulse small, great faintness. II

p.m., forehead covered with clammy sweat, occasional faintness, waxy complexion, short sobbing respiration, retching, vomiting ; violent burning thirst, heart's beats hardly perceptible,icy cold extremities, died between 12 and 1. P.M. on 31st. Face pale, both eyes open, pupils dilated, cornea dim, jaws firmly closed, neck bluish red, hands clenched, abdomen much distended, sugillations all over back. Redness of peritoneum and external surface of bowels ; m.m. of stomach softened and in some places perforated in holes the size of a farthing to a penny; great softening of m.m. around holes, which are as if eroded; rest of m.m. red, sunken and easily detached. Small intestines as far as valvula coli, red, swollen and soft, liver hard, red in places, green bile in gall-bladder. (FRANQUE, Nassauer Journ., ii, pt. 4, 313 ; in Frank's Mag., ii, 393.) 15. A man, æt. 40, suffering from chronic rheumatism, took in e. Ziij ofwine of of seeds, went to bed and fell asleep. Woke at 2 a.m. and had a copious stool and a second towards m. Soon after the first pressure and anxiety in præcordia, frequent vomiting of yellowish-green fluid ; this increasedduring d. so that he vomited all the food he took after severe retching, or quite easily and byjerks. Thirst extreme, especially for cold drinks. After continuous vomiting for 24 h. great weakness and exhaustion ; face pale and features sunken, blue rings round eyes, skin cool, pulse small, tense, urinary secretion scanty. Next d. hiccup. (BENNEWITZ, Hufeland's Journ., xciv, pt. 4, 107 ; in Frank's Mag., ii, 699,) 16. An unmarried lady, æt. 57, who had suffered for 4 months from pains in

epigastrium and abdomen, got by mistake on Sept. 16th, 7 a.m., 30grm. tinct. with 15 grm. Glauber's salt. After 5 m., frightful pains in stomach and bowels, with extreme anxiety and great excitement. Face pale, pinched, eyes surrounded with dark rings, stomach and abdomen intolerably painful, complains ofoppression andstrangulation, pulse 50, weak, vomiting of viscid stuff, several liquid, blackish, very fœtid stools with violent colic. She got 5 centigr. oftart, em., which caused her to vomit and the vomiting was promoted by drinking warm water. All this between 8 and 9 a.m. Iodinewater allayed the pains. 10.30 a.m., the vomiting continued and was accompanied by convulsive movements in the cold limbs, hands violet coloured. 8 p.m., prostration, vomiting, and diarrhea, convulsive movements in limbs, subsultus tendinum, extreme restlessness, pains in abdomen,pulse 65, only a few drops ofurine passed.- 17th, m., symptoms continue, pulse 84, general heat, tongue dry, great thirst, urinary secretion quite suppressed, but the convulsive movements and strangulation gone. Leeches to epigastrium, cataplasms, liniments and tisane. Inafter. noon much better, very copious micturition.- 18th. Improvement goes on.-20th. No more fever, but diarrhea continues.-Oct. Ist. Quite recovered from the poisoning. (LEROY DES BARRES,Bull, de l'Acad. Nat. de Méd., xiii, 1013.)

Volume IV — Appendix

COLCHICUM.

(See vol. ii, pp. 316, 748.)

III. — 2. Dr. Roy, of Vevey, reports experiments made on cats by intravenous and hypodermic injection. He observed severe diarrhcea, and, P.M., great congestion of the intestinal canal — a veritable enteritis. These phenomena were due to the elimination of the C. and not to a nervous action or a general augmentation of circulatory pressure. The red and white corpuscles found in the stools showed that actual transudation of the liquid constituents of the blood had occurred. {Archiv. de Phys.^ 1878, p. 655.)

II. 2. (This case is correctly and fully given up to 1. 18, but then ends too abruptly. The followmg is the sequel, verbatim :)

After 3 h., in addition to above symptoms, he had pain in back ; at 9 p.m. his abdomen was tympanitic. Nov. 2nd. — He had the appearance of a moribund person, great weakness, pulse very small and quick, face Hippocratic, of an earthy hue, hands and feet cold, abdomen tympanitic, vomiting and diarrhoea occasionally, evacuations as before, no blood in them. Voice low, but consciousness perfect ; pressure on abdomen caused no pain, only anxiety. The pains along the back and in heels continued along with the anxiety and dyspnoea. Consciousness continued till death, which took place at 10 a.m., 39 h. after taking the drug. P.M.^ 29 h. after death. — Face much sunken, abdominal integuments green coloured and greatly distended by g as On cutting open abdomen some fetid gas escaped. Intestines enormously distended. The whole of the small intestines, especally duodenum and jejunum, showed on their peritoneal coat brown spots ; had greatly injected blood-vessels, and a diameter of at least 1 1 inch.

Their m.m. considerably inflamed, most so near the stomach. Swelluig of Brunncr's and Peyer's glands to the size of a lentil, and puckering <rf the m.m., which, however, could not be detached by the handle of the scalpel. The contents of the bowels resembled the stools. The whole mesentery was inflamed, its blood-vessels greatly distended with black blood like the large vessels of the abdomen. The stomach was distended to 3 times its proper size, its peritoneal coat dark red with spots of still darker red. It contained an immense quantity of fetid gas, and about 3 cupfuls of fetid yellow fluid; its m.m. was dark red, nearl]r brown, much thickened. The coats of stomach and bowels were firm and not perforated. The colon was only distended by gas, but not inflamed. Other internal organs sound.