Cannabis sativa

Richard Hughes & Jabez P. Dake tarafındanA Cyclopaedia of Drug Pathogenesy

Volume I — Main text

Cannabis aatiya. Common hemp.

  1. Pravings. — i. Hahnemann, Mat. Med. Pura^ vol. i of original and translation. Contains 283 symptoms from self and 8 others, and 47 from authors.

  2. April 7th, 7 a.m., took 10 dr. tinct. — 9th, 7 a.m., 30 dr. No symptoms. — nth, 7 a.m, 70 dr. At 12 noon, severe tearing and biorin^ in r. side of skull — a symptom often observed without taking medicine. 3 p.m., weight and heat in sinciput till e. 4 p.m., shooting in end of urethra repeatedly, not when urinating. (Lembke, Z./ h. Kl.j iv, 155.)

  3. Nov. 26th, I dr. tinct. Strong erections in m. after coitus in n. ; stoob irregular, much pressing required, attended with tenesmus, which continues after evacuation ; sometimes has sudden call to soft stool; ft^uent urging to urinate, sometimes with burning, urine turbid ; sexual desire goes ofF later. The first 2 d. on waking in m., verticallv disposed, shining, white points extending in lines from one eye to the other, they eo ofF some time after rising, later flickering before eyes, light and (dark points hover in different directions before the sight. After 4 d., in 1. ear a ringing as if a stretched string were struck, which reverberates a long time ; an inflamed pimple in r. ear, very painful when touched, with swelling of inner ear, matter forms after 4 d., which is discharged mixed with blood ; ebullition of blood to head with heat ; at n. very hot, sweats towards m. ; his nipple inflames, itches, is painful to touch ; a pustule beside it which does not burst, but goes o£F after a few d. On hairy scalp, on nape and behind ears painful tender pimples, which heal up in a few d. without scabs ; aching and itching in eyeballs ; scraping and burning in throat for some d., he must hawk and has dry cough, in the m. much mucous expectoration. After 10 d. oppressed breathing, precordial anxiety, stitches between scapulae, aggravated after eating, relieved by sitting. After 12 d. vomiting after coffee of viscid acid slime. On stooping cramp in nates, must rise up immediately ; several such atucks. — Dec. 2nd, 2 dr. Afternoon and e. his thoughts are confused and he writes in the wrong place, at same time heat and ebullition in head, but chilliness in open air, itching in fingers and hands ; vivid agreeable dreams ; depressed spirits.— 9th, 5 dr. Woke next m. at 6 o'clock with urging to stool, but nothing but wind passed and the urging continued. After a pipe had a hard stool, with nausea and inclination

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to vomit, — lOth, 10.30 a.m.j 4 dr. Immediately forgets what he was going to write, retching and inclination to vomit. After 3 h. needle pricks in tip of r, ring finger. Later in afternoon, feeling of great coldness under nails ; slight drawing in a hollow tooth, especially when something acid touches it. — i ith. Awoke with great nausea and tJicli* nation to vomit, especially when lying on r, side ; for several d. great appetite in e*, eats too much and is sick ; uncomfortable and depressed all d. with eructation of air and fulness in abdomen. and no appetite till n., when appetite returns ; in e. chilliness, yawning, stretching limbs and laziness; prickly feeling under I big toe as if great coldness were under nails ; cramp in r. heel ; itching wheals on arms and nape, which soon go ofF; toothache drawing in a hollow tooth and violent shooting on sucking it out with tongue i r. side of palate swollen and a lump on it as from a gumboil, — 12th. Woke in m. with nausea and inclination to vomit, all m. uncomfortable yawning, sleepy, lazy, inclined to do nothing ; rumbling in bowels, slight spasm in stomach, which feels empty, though he cannot fancy anything to eat» Imperfect erection during coitus without voluptuous feeling or ejaculation. Mouth of urethra somewhat inflamed, painful, and feels hard. Much flatus m., stool in small pieces, with flatus 5 after coitus without pleasure, strong painful erections at n. which woke him up ; cuttingshooting in orifice of urethra j spasm in stomach ; nausea and hawking of mucus and vomiting, relieved by coffee; depression of spirits ; in m. visible and perceptible pulsation of temporal arteries — 14th, 20 dr# rst diL Immediately nausea and vomiting at first of bitter then of insipid mucus with great straining; teeth on edee ; afterwards hunger; L cheek red but cool, r. pale, r. teeth painful After \ h. pinching in belly, like call to stool. After i h. ebullition towards head when writing ; heartburn ; woke» m., with urging to stool ; in spite of much straining only wind came, the urging to stool and urine continued till he took coffee and smoked a pipe, when he had a broken- up stool, but vomited the coffee; itching in urethra; eruption of papules, which itch and smart, on chest and back. — ist d., shooting in rectum, with a kind of contraction of sphincter, frequently, when walking; afternoon, a strangling sensation in 1. testicle when walking, the epididymis and spermatic cord swollen in lumps like beans. — 2nd d., sore*throat as if raw, with great dryness, worst m. in bed, after rising expectorated a lump of mucus and felt better ; scrapy and dry in chest ; i h. after breakfast general discomfort, especially in abdomen, as if blown out, with shooting-cutting pains there and chilliness all over; eructation with taste of food, later of mere wind ; teeth on edge ; hawking of mucus difficult to detach that irritates throat ; feet feel heavy when going upstairs ; sensation as of sand in r, eye ; very distracted, cannot comprehend things easily, hardly knows what to write, confused thoughts ; urging to stool after dinner and dwrhaea, later itching and pricking in rectum ; sleepy for | h, after dinner ; itching on chin and tip of nose ; when sitting r. natis becomes painful and r. leg goes to sleep i shooting^pressing pain in 1. little toe formerly the seat of a corn ; e», burning in eyes ; spasmodic pain in stomach'^ m. ; heaviness and going to sleep of r, hand, relieved by moving it. — 6th d., violent

burning of all skin^ especially feet, hands, palms, and belly, all n.,and next m. a painful pustule on nape. (Schreter, N. Archiv^ iii, i, 172.)

  1. Mrs. S — . Dec. and, 7 dr. tinct. After 3 h. (at 10 a.m.), earache and pain in throat, then coldness with heat alternating with dull headache, aggravated by moving and stooping as if all within head were shaken, so that she must walk quite stiffly or sit quite still leaning against something, frequent stitches in head on 1. side and behind r. ear \ the stitches so violent they made her start, lasted at n. in sleep, so that she moaned and

froaned and frequently woke. Pressure on eyelids so that she can with ifficulty open them, and stitches round about orbits ; some heat and fever, glowing hot face, but it felt cold when she moved ; severe pains in throat, which is swollen outside and inside, with dysphagia ; very tired, must lie down all d. Shooting in upper arm and bones of little finger, this lasted 3 d. ; in the flesh on outer side of 1. tibia pain like a bruise, then shooting in whole 1. extremity ; shooting and pain in 1. ankle-joint, relieved by washing in cold water ; stool thin and yellowish, passed by mistake, thought it was wind ; pains in abdomen, cutting, not removed by rubbing;, but only by drinking cold water ; urine scanty ; no voluptuous feeline during coitus \ dizziness for some d., the room seemed to turn round wiui her. — loth, 10.30 a.m., 4 dr. Always giddy, things seem to whirl round ; hiccup, m. \ itchine-shooting in vagina, and leucorrhoea after coitus ; urine scanty ; slignt bellyache before stool. Itching pimples on neck, nape, and chest ; gum around a decayed tooth inflamed, swelled and painful ; head constantly dizzy, it felt as if moving from one side to the other. — 14th, 20 dr. ist dil. Drawing pains in a decayed tooth with swelling of gum, e. ; before stool always slight bellyache ; stool sometimes loose, sometimes hard ; itching around knee; a nollow tooth crumbles away. [Ibid,)

  1. From taking some tablespoonfuls of an infusion of 3ij fresh can. sat. in Jviij water, — vertigo, confused head, headache, tinnitus aurium, pale face, dryness of mouth, viscid mucus in throat, eructation, complete anorexia^ loss of taste, cough ; weak, often inaudible, voice, oppressed breathing and pressive pain all over chest, transient violent palpitation of heart, exhaustion, eruption on head and chest consisting of white vesicles filled with serum, with red areola, burning when touched. (Knorre, A. h. Z., vi, 34.)

  2. April 20th, 5.15 p.m., Wibmer took 5 dr. tinct., pulse being then 75* At 5.30, 10 dr. After 5 m., slight frontal headache, dryness of mouthy throat, and lips. At 6 p.m., 20 dr. Taste disagreeable. After 10 m., slight headache with slight throbbing and pressure. At 6.30 p.m., quite well. Then he took 40 dr., the pulse being 78. Slight headache came on. At 7 p.m., on getting up, felt the limbs much fatigued, this went ofF by walking. — April 21st, at 11.45 a.m., pulse being 80, took 50 dr. Taste disgusting. After 7 m. some drawing through forehead. After ^ h. fronul headache, which lasted till I p.m. After 3 d. the fatigue of limbs increased, especially of lower limbs, with violent pain in sacrum, which compelled him to sit and rest after the slightest exertion ; at same time drowsiness and paleness of face. On the 6th d. the throbbing headache, with heat of head and fever, recurred, compelling him to lie down. Venesection to 12 oz.,

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leeches and cold compresses to the head, relieved the headache, but the pain in sacrum, the weariness and fever, continued longer. There was also complete anorexia, thickly furred tongue, and constipation, though he had suffered from diarrhoea a few d. before. This condition kept him nearly 14 d. in bed, during which the symptoms gradually subsided, but there long remained anorexia and complete loss of tone in intestinal canaU The strongest purgatives in large doses were unable to clear out bowels of faeces and flatulence. For many weeks afterwards he suffered from weariness of limbs, impaired digestion, and great paleness and leanness of face, {(f'^rk. d, Jrzneim, u, Giftty ii, 230.)

7- a. About 4.30 p.m,, I took a very large dose of an extract from a hemp plant grown in Kentucky, the summers of which approach in heat the more temperate parts of India. No immediate symptoms were produced. About 7 p.m. a professional call was requested, and, forgetting all about the hemp, I went out and saw my patient. Whilst writing the prescription I became perfectly oblivious to surrounding objects, but went on writing, without any check to, or deviation from, the ordinary series of mental acts connected with the process, at least that I was aware of. When the recipe was finished, I suddenly recollected where I was, and, looking up, saw my patient sitting quietly before me. The conviction was irresistible that I had sat thus many m-, perhaps h., and the idea directly occurred that the hemp had began to act, and had thrown me into a trance-like state of considerable duration, during which I had been stupidly sitting before my wondering patient.

b, I hastily arose and apologised for remaining so long, but was assured I had only been a very hw m. About 7.30 p.m. I returned home, I was by this time greatly excited, and the feeling of hilarity now rapidly increased. It was a sort of bien-etre, a feeling of inner joyousness y the heart seemed buoyant beyond all trouble ; the whole system felt as if all sense of fatigue were for ever banished ; the mind gladly ran riot, free constantly to leap from one idea to another, apparently unbound from its ordinary laws. I was disposed to laugh j to make comic gestures j one very frequently recurrent fancy was to imitate with the arms the motions of a fiddler, and with the lips the tunes he was supposed to be playing. There was nothing like wild delirium, nor any hallucinations that I can remember. At no time had I any visions, at least any that I can now call to mind ; but a person who was with me at that time states that once 1 raised my head and exclaimed " Oh, the mountains, the mountains ! ** Whilst I was performing the various antics alluded to I knew very well 1 was acting exceedingly foolishly, but could not control myself.

r. I think it was about 0 when I began to have a feeling oi numbness in my limbs, also a sense of general uneasiness and unrest, and a fear lest I had taken an overdose, I now constantly walked about the house. My whole surface felt flushed and warm ; my mouth and throat were very dry ; my legs put on a strange, foreign feeling, as though they were not a part of my bodv, I counted my pulse, and found it 120, full and strong. A foreboding, an undefined horrible fear, as of impending death, now commenced to creep over

me : in haste I sent for medical aid. The curious sensations in my limbs increased ; my legs felt as though they were waxen pillars beneath me. I remember feeling them with my hand, and finding them (as I thought at least) very firm, the muscles all in a state of tonic contraction.

d* I then began to have marked ^^ spells " — periods when all connection seemed to be severed between the external world and myself I mieht be said to have been unconscious during these times, in so far that I was oblivious to all external objects ; but on coming out of one, it was not a blank, dreamless void on which I looked back, a mere empty space, but rather a period of active but aimless life. I do not think there was any connected thought in them ; they seemed simple wild reveries^ without any binding cord — each a mere chaos of disjointed ideas. The mind seemed freed from all its ordinary laws of association, so that it passed from idea to idea, as it were, perfectly at random. The duration of these spells was to me very great, although they really lasted but from a few seconds to i or 2 m.. Indeed, I now entirely lost my power of measuring time ; seconds seemed hours, minutes seemed days, hours seemed infinite. Still, I was perfectly conscious during the intermissions between the paroxysms. I would look at my watch, and then after an h. or two, as I thought, would look again and find that scarcely 5 m. had elapsed. I would gaze at its face in deep disgust, the minute-hand seemingly motionless, as though grown in the face itself, the laggard second-hand moving slowly, so slowly. It appeared a hopeless task to watch during its whole infinite round of a m., and always would I give up in despair before the 60 seconds had elapsed Occasionally, when my mind was most lucid, there was in it a sort of duplex action in regard to the duration of time. I would think to myself. It has been so long since a certain event, — an h., for example, since the doctor came ; and then reason would say. No, it has been only a few m. ; your thoughts or feelings are caused by the hemp. Nevermeless, I was' not able to shake off this sense of the almost indefinite prolongation of time, even for a minute.

/. About 8.45 I was standing at the door, anxiously expecting the doctor, the spells coming on from time to time, and unaccompanied by any muscular relaxation, so that I remained standing, leaning perhaps slightly against the doorwav. After a while I saw a man approaching, whom I took for him. Tne sound of his steps told me he was walking ytxy rapidly, and he was under a gas-lamp, not more than the fourth of a square distant, yet he appeared a vast distance away, and a corresponding time approaching. This was the only occasion on which I noticed an exaggeration of distance ; in the room it was not perceptible. My extremities now began to grow cold, and I went into the house. I do not remember further, until I was aroused by the doctor shaking or calline me. I narrated what I had done and suffered, and told the doctor that my opinion was that an emetic was indicated, both to remove any of the extract still remaining in my stomach, and also to arouse the nervous system. I further suggested our going into the office, as more suitable than the parlour, where we then were. There was at this time a very marked sense of numbness in my limbs, and

what the doctor called a hard pinch produced no pain. When I attempted to walk upstairs my legs seemed as though their lower halves were made of lead.

/; After this there were no new symptoms, only an intensifying of those already mentioned. The periods of unconsciousness became longer and more frequent, and during their absence intellection was more im* perfect, although when thoroughly roused I thought I reasoned and judged clearly. The oppressive feeling of impending death became more intense — it was horrible. Each paroxysm would seem to have been the longest I had suffered ; as I came out of it, a voice seemed constantly saying, " You arc getting worse ; your paroxysms arc getting longer and deeper ; they will overmaster you ^ you will die/ A sense of personal antagonism between my will-power and myself as affected by the drug grew very strong. I felt as if my only chance was to struggle against these paroxysms ; that I must constantly rouse myself by an efFort of will, and that effort made with infinite toil and pain* I felt as if some evil spirit had the control of the whole of me, except the will-power, and was in determined conflict with that, the last citadel of my being. I have never experienced anything like the fearful sense of almost hopeless anguish and utter weariness which was upon me. Once or twice during a paroxysm I had what might be called nightmare sensations ; I felt myself mounting upwards, expand^ ing, dilating, dissolving into the wide confines of space, overwhelmed by a horrible, rending, unutterable despair. Then, with tremendous effort, I seemed to shake this off, and to start up with the shuddering thought. Next time you will not be able to throw this off, and what then ? Under influence of an emetic I vomited freely, without nausea, and without much relief. About midnight I went upstairs to bed. My legs and feet seemed so heavy I could scarcely move them, and it was as much as I could do to walk with help. I have no recollection whatever of being undressed, but am told I went immediately to sleep. When I awoke, early in the m., my mind was at first clear, but in a few m, the paroxysms, similar to those of the e«, came on again, and recurred at more or less brief intervals until late in afternoon. AU d* there was marked anaesthesia of skin. At no time were there any aphrodisiac feelings produced. There was a marked increase of the urinary secretion. There were no after-effects, such as nausea, headache, or constipation. (H. C. Wood, Therapeutics^ sub voce.)

8, a. P. A — 5 act. Z4; nervous temperament, good health. Took 3 grms. of fresh alcoholic extract i h. before eating. Felt about midmeal vague sensation of drawing (tingling), which is a commencement of anaesthesia of skin, and which has been likened to that feJt on entering bath. Soon palpitation of heart came on, increased^ then diminished and disappeared only to come again shortly after. Pulse small, rapid, at times irregular, Difliculty in swallowing, owing to want of saliva, and I could not eat any more. Feeling as if " stunned " and of compression in head. Felt no longer master of myself i remained motionless on chair for some time. Pulse rapid, about loo. Breathed strongly, puffs of heat rising. Head began to make circular move* mcnt, which, extending to whole body, carried mc off with chair on

which I sat, and I fell down. This happened twice more ; I got up then and walked, but as if I had St. Vitus's dance, made contortions and grimaces, burst out laughine, emitted harsh cries. I often had brief remissions, during which I tdd bystanders that the effect was over, but I could not finish my phrase before a severer attack came on. Movements suddenly eot more regular, and I began to dance, turning and singing, until I fell down worn out. Got up a moment later, and sat down in armchair, shut eyes, and soon felt sensation in head as if stunned and compressed stronger and stronger ; at same time I lost consciousness of existence of my limbs. I can only compare this to sensation experienced just before losing consciousness under chloroform. Remained in this state five or six m., then I returned for a moment to normal state. Had been during this attack very sad, whereas previously I was very gay. Felt effects going off, got on to a bed, slept for 20 m. pursued by tiring thoughts, woke up quite well again ; whole effects lasted 2 h.

t. Took 2 grms. of another extr. 20 m. before food. Very acrid taste, nearly nme me vomit. Effects began in 5 m., had vertigo and tendency to laughter, ran about, gesticulated for 10 m., then I sat down, determined that no one should notice anything of my state. Nevertheless, I could not contain myself on the entrance of somebody. Had contortions, got up, ran about gesticulating and with choreic movements. Sat down to dinner after awhile, could not eat owing to total absence of saliva. Got up and walked like one with St. Vitus^s dance. Pulse frequent, no. Tension about head, deep inspirations, eyes red, attacks of gaiety. This state lasted 2 h. and then entirely disappeared.

c. At 10.5 a.m. I swallowed 4 grms. of another ; pulse 80, conjunctiva slightly red. 1 0.40, ate as usual. At 1 1 felt effect beginning. Disposed to speak and laugh, but resisted. In to m. I was quite under its influence. I left the house tottering as I went, felt great tension about head, heat in eyes. Legs very heavy ; feet felt dislocated and turning now inwards, now outwards. Heart palpitated. 1 1 .30, pulse too rapid to county conjunctiva very red, eyelids half closed. Have feeling of intense bewilderment, tremblings in wrists, can hardly write. 11.40, head very heavy, tendency to immobility, sensation of undulating flames before eyes, conjunctiva very red, pupils strongly dilated. Eyelids are seat of sensation of heat and pricking at ext. angle ; pulse 170, small, compressible, very irregular; palpitation, beatings at nape of neck, tongue dry, no thirst. 12.5, same state of eyes, they seem to me swollen ; feel spasmodic closing of jaws, pressure at temples ; pulse 130. 12.10, undulating feeling in whole body, sight dim, leaden countenance, sensation of pressure at mastoid processes, and of hissing in ears. 12.18, great weight of head, eyes painful, pupils dilated, sensation of flames before eyes, great dryness of mouth and nose, tongue dry, covered with white dried mucus ; pulse 140. I feel in a world which is no longer the same. 12.35, want to urinate, but find great difficulty. Eyes same ; very tired ; I go to bed. At 1.15 I get up, I seem to have lain a long time. Numerous ideas have rolled like torrent over my brain, but I can recall none. Head very heavy, can hardly see to write i nausea, mouth very dry i when I bend over the paper I have

;annabis sativa.

difficulty to combat inclination to immobility. I press my pen n\

cold extremities, no warmth at skin, frequent want to urinate i

to have been long thus. 1*30, mouth always very dry, tongue o

with white lines, dryness of pharynx* 2, pulse 130, weight s

gastrium* 3, face very palc^ same redness of eyes, great mti

weakness. A friend comes, who continues observ^ation for me,

breathing frequent, heart •beats weak. Patient complains of palpii

pulse 130, small, compressible, fcice pale, like one affected with

disease of brain, eyes injected, very' bright. Digestion retarded.

pulse 110, he hardly answers questions. 5, went out, was bew

all the time. 5*30, took some soup. 7, loud hissing in ears, palpi

general stiffness. Symptoms increase. 9.15, can hardly stan *

pains top of head, r. side , pain at bottom of spine, and in coxo-fis

joints i very tired ; pulse 140, downcast look. 10, to bed. B

very stiff, moved arms with difficulty, lost sensation of anythi

contact with me, my body seemed transformed into solid mass.

frightened at this state, which went away and often returned

hear an intense noise, a great bell. Slept at 1 1.30, woke often 1

n. Next m* thought I was cured ; no headache, pulse slow, bui

heavy as soon as I got up, and mind troubled. Ate little, tens

head increased. This was repeated for 9 d., viz. feeling w

waking, but head heavy on rising and mind clouded and uniit for

lectual work. Constipation remained for some time after. (P]

Albert, Ohs, iur U Qianvre indigene^ Strasburg, 1859.}

9, Mdllc, X — -^ set. 25, nervous temperament, imprcssionabl< constitution and healthy took 2 grms. of 2nd extract 15 m. bcfor While eating she became first of all very preoccupied, then began gluttonously, which was contrary to her habits. Toward* end ( she looks at people at table with astonished air and strange expi then bursts into ceaseless laughter interspersed with harsh called to her loudly to make her stop \ she did stop, got up, and to go about room with preoccupied air, sometimes stopping, round on her heclj and then going on again, PuJse very fro though small ; mouth dry, eyes red, palpebral circle narrowed. then to walk in grotesque manner and laugh loudly, then advanced tically towards a person and bowed repeatedly to her, then bui laughing. Walked on again mumbling something unintelligibj denly sat down, became very pale and fainted. Breathing bcca: cult, pulse very frequent, very small, so much so that I cot longer feel it. Muscular relaxation complete. In a short tii called in low voice, saying she could not see, and that she was pupils very dilated, eyelids drooping, could not move, but Itml not stiff. Gave her a cup of tea, which made her vomit a good she was put to bed, and remained in comatose state, rarely ani questions. Pulse increased a little, second cup of tea made her again, and prostration followed these attacks, which had lasted 4 h* d. was quite well. [Ibid.)

10, a. M. L~, 5.5 p.m., pulse 80, regular; state normal j 2i grms. of 3rd exc, sits down to cat at 5.10. At 5*25, face fa animated,b\oodio Wa.&^:^cQm^%:^W'»x\H«. S^IO-^ inclines hea4

r. Pulse lOO. 540, fidls on one of his comrades with loud burst of laughter. 5.50^ we took him away with us ; on way he spoke with volubility, ran, dragging people whose arm he had. When he got to bis room, 6.40, pulse 100, still talks, but has calm moments. 7 p.m., almost in normal state again, only slight heaviness of head. 7.15, pulse 80, quite well again.

b. At 4.15 p.m., 2 |grms ; at 6, dined with much appetite. Up to 8 p.m. he was only excited, making him speak much, but spoke sensibly. Pulse 90, breathing regular. From 8 to 9.30 he felt fatigued 5 pulse 80. Nothing noteworthy^ but at 9.30 he had strong sensation of heat, breathing more frequent, eyes became injected, great lassitude came on ; pulse 120. At same time had such feeling of well being that he would not be disturbed. Weakness persisted ; he fell asleep ; pulse 1 00.

c. Took (next d.) at 9.50 a.m. 6 grms. extr. fasting. Pulse was 75, breathing regular. Began to eat at 10.35. At 10.50 effect began \ look is undecided, eyes begin to inject ; pulse 100, small, breathing frequent. At 1 1, he becomes very loquacious, leans to r. and 1., wanders. Begins phrases which he cannot end \ pulse 120, eyes and face congested, cold extremities. 11. 10, agitated and wanders stilly will not have pulse felt, and laughs loudly. 11. 15, face is the seat of partial contractions ; does not speak any more, looks sad, and inclines his head ; pulse no. 11.20, wanders again, cries out, very agitated ^ he notices himself that he is talking nonsense ; face has look of stupor ; breathing frequent and impeded ; eyes very congested, haggard. 11.25, same wanderings, is joyous, rallies, and seems to be quarrelling with an Invisible being, who he thinks wants to harm him. Gets up and sits elsewhere. 1 1.30^ begs people to excuse the ^^ neglige '' of his dress with very sad look ; sighs and goes with contrite air to lie down full length on sofii. Cold extremities \ noisy breathing ; pulse 140, irregular, small ; mouth very dry \ however, he spits constantly ; drinks much. 1 1.40, he shuts his eyes, does not move, nor answer questions. A child passes singing in the street \ he says he hears an harmonious voice. 1 1 .55, pulse 1 10, same state. At 1 2, same torpor \ the clock strikes at cathedral,

.at the first beats he complains that they have been ringing very long, complains thus at each stroke of the clock. 12.15, ^^^^ injection of eyes, hageard look \ pulse no, same wandering, nausea, pupil is not contracted and remains sensible to light. 12.25, same sute of pulse, nausea, slight vomiting, falls into state of torpor and then complains of headache. He does not feel returning to normal state. Intellect still

At 3 p.m. he still had tension in head, but intellect was clear. All rest of d. he had heaviness of head and headache. After dinner at 6, he had an attack again which looked like drunkenness. Felt very tired and went to bed early ; agitated sleep, but well next d. (Ibid,)

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