Senega

Volume IV — Main text

SENEGA.

Polygala SS*tga, L. Snakewort. Nat. Ord., Poljgalacea.

1. Pravings. — I. Dr. Massie took 10 gr. of gum dissolved in water. In 5 m. sensation in oesophagus as if membrane had been abraded, lasted i h. Pulse, 84 before experiment, at 15 m. was 78, 20 m. 73, 30 m. 70, 35 m. 68, thence gradually rising to 76. He then took 20 gr. Irritation in oesophagus was again felt, with some nausea ; the drug also operated slightly as a purgative. {Inaug. Thtsis, Penns. Univ.., 1803 » fr***" Allen.)

2. Mr. L. took 20 gr. of powdered root. In 10 m. burning sensation in oesophagus with considerable discharge of mucus from trachea (still continuing in slight degree i^ h. later). Pulse, 65 before experiment, in 10 m. was 70 and AiUer ; later 72, whence it fell again. {Ihid.)

3. Mr. L — t took same. Had similar feeling in oesophagus, with much hawking of mucus. In 30 m. nausea, which increased up to 40 m. Pulse, 65 before experiment, gradually rose in 5 — 40 m. up to 90, and was still 80 — 86 after 1—2 h. In l i h. skin became very hot j in if h. profuse perspiration set in, and disagreeable symptoms were quite removed, {ibid.)

4. Mr. W. took same. Same irritation in oesophagus ; pulse, 68, was 80 at 30 — 40 m., and only returned to its starting-point in 2^ h. {IHd.)

5. Mr. T. took 10 gr. of resin dissolved in spirit. CEsophageal irritation immediately, with a good deal of nausea ; both still present at 40 m. Pulse, 72, at 10 m. was 88, much increased in fulness, but somewhat irregular. At 35 — 80 m. it had fallen to 65. {Jiid.)

6. A lady took 20 gr. of same. CEsophageal sensation as in No. 5. At 10 m. considerable nausea, which at 40 m. had subsided. Pulse, 76, at 15 m. was 92, and much fuller. After 20 m. it slowly fell. (Ibid.)

7. Mr. R. took 20 gr. of gum in water. In 5 m. there was copious vomiting. No other symptoms. {Ibid.)

8. Mr. P. took 32 gr. of gum in pills. In 10 m. much nausea, whidh in 20 m. was so much increased as to be quite distressing, and

medicine was with difficulty retained on stomach ; it then diminished, and at 60 m. had quite gone. Pulse, 72, rose during 20 m. to 82, thence slowly declining, {Hid.)

g. Seidel, a strong, florid man. a. Took 10 dr. of tinct.* Soon after, staring at an object, feels as if eyes moved with difficulty ; dry cough shaking whole chest. In ^ h. dull pain in r. ear, and feeling of warmth in it. In i h. feeling of warmth and as it were of palsy in I. face. In 4 h. pinching and forcing in chest; fugitive stitches in chest during inspiration, while resting. On first days increased thirst. On 1st, 2nd, and 3rd d., when stooping violent congestion to head, especially to eyeballs, where there is pressing pain. On 1st d. pufFy eyelids ; when stooping pressure in eyes as if fluid penetrated into eyeballs, expanding them ; illusions of sight ; repeated eructations ; oppression of chest, especially during rest ; violent pressive pain in chest on awaking in m. (first 8 d.), also when awakingduring n. ; pain in chest aggravated in recumbent posture ; stitching and crawling and pricking in palms of hands ; bodily and mental exhaustion ; anxious jerkings and twitchings in upper arm during afternoon sleep ; diminished secretion of urine (also 2nd and 3rd d.). On 2nd d. chilliness with exhaustion in legs (also 3rd) ; shadows before eyes ; drawing sensation as from a foreign body in integuments of r. abdomen while walking ; cough during breakfast; sudden violent pain in small spot of r. side while walking; pressive pain in chest, especially during rest, lasting several weeks ; a small pimple pains at slightest touch ; scraping and dryness in throat, hindering speech and obliging him to cough. On 3rd d, congestion to chest with violent throbbing therein ; marked stitches in small spot deep in 1. chest, aggravated by cough and certain movements (also 4th d.) ; soreness 1. side of chest (also 4th d.) j bruised pain of muscles of 1. thigh with exhaustion of whole body and laziness of mind. On 4th and following d. violent itching in legs compelling to scratch, by which, however, it changes into burning, especially e. in bed.

b. Same took 15 dr. Immediately, irritation in throat causes a few dry coughs. In ^ h, paralytic pain and drawing from 1. elbow to little finger, as after a violent knock. In 1 h. violent compression of upper chest, especially during rest ; pinching pain in upper r. chest with dull stitches ; sharp pressure deep in 1. eyeball. In 3 h. objects appear shaded ; slight searching in upper I, molars. In first days insipid taste in mouth in m. ; increased thirst ; diminished secretion of urine ; oppression of chest, especially during rest ; stitches, crawling and pricking in voia. On 2nd and 3rd d. crawling in chest. On 3rd d. soreness between 3rd and4rh I. ribs, increased from pressure or aggravated to stitches ; pain in several teeth and in jaws. On 4th d. strong congestion in chest, almost to faintness, sitting ; violent forcing and pressing in chest ; sleep deep, full of dreams, with confusion in head on awaking.

c. Same took 20 dr. Soon, forcing and tightness in chest. In 2 h. griping in stomach with desire for stool. In 4 h. stitches in 1. vola. In first days, dizziness in head with insipid taste in mouth in m.,

• Tincture used io following proviogs vras prepared with xo parts of rectified spirit to I part of dried and powdered root.

and yellowish-white fur on tongue i swollen eyelids; increased thirst. On 1st d.j eyelashes covered with hard mucus ; severe pressure in eyeballs, now r., now 1. ; impaired vision as if dazzled from strong h'ght ; when reading dazzling before eyes, rendering it difficult; dryness in mouth and throat with accumulation of tough phlegm j when hawking, rawness in throat ; lessened appetite ; diminished secretion of urine ; certain movements, especially stooping forward, cause pain in chest, as if it was too narrow, there is desire to expand it by repeated stretching, which however produces marked soreness in it ; violent pressive pain in chest early on awaking (also for 7 following days, same when awaking during n. for ist days), pressing on chest increases pain ; tightness and crawling in upper chest, especially at rest ; bruised feeling in gluteal and femoral muscles ; drowsiness in e. (also following days); after lying down, deep stunning sleep (do.) ; without cause sudden very distinct remembrance of irrelevant sceneries seen long ago, which had not made any particular impression on him before. On Ist n., rest disturbed by dreams, unremembered ; sleep restless and broken from oppression of chest. On 2nd and following days, boring stitches in head ; dull headache in m. ; pressive stunning pain in occiput ; dryness of nares with discharge of a few drops of blood ; shortness of breath and oppression of chest in going upstairs ; dull stitches under short ribs, 1. side ; restless tossing about in sleep. On 3rd d., drawing in eyes followed by cool sensation and tears ; burning and pressure in eyes towards e. On 3rd and following days, tough phlegm in larynx induces frequent hawking with expectoration of small lumps of it; pressive pain in chest. On 4th d,, violent pinching pain in chest, especially 1. side, with restlessness and anxiety during rest. From 6th to gth d., dull stitches in middle of chest, intermittent. On 6th and following days, when treading firmly or running, chest is violently shaken as if everything in it was sore. On 6th and 7th d., faint feeling while walking in open air p.m. On 7th d., dull stitches, followed by violent oppression in chest, with lassitude of lower limbs, perspiration and malaise (almost faintness), while walking in open air ; very painful burning with repeated stitches in upper I. chest, worse at rest. On 8th and gth d., pressive pain between shoulder-blades, especially when treading firmly or making other movements by which the chest is shaken. On 9th d., when treading firmly, walking fast, or running, violent tearing soreness right through chest from front backwards (as if in mediastinum), rendering every motion difficult (lasting several weeks) ; violent pain and concussion through middle of chest, especially along dorsal vertebrae, lasting some d.

tl. Same took 30 dr. Soon after, dull pressing headache ; burning and scraping in throat. In i h., lower eyelids are drawn spasmodically towards nose (lasting several d.) ; some sharp stitches through I, chest. In 14 h. tightness and dull pressure in chest. In 2 h. dryness in mouth. In 2 — 3 h., tickling of ptceputium audi glans ; pinching pain by jerks in glans. In 3 to 4 h., drawing and pressing in eyeballs, with diminished power of vision. In 4 h., crawling underneath tongue, also in small spots of chest, more superficial than pleura ; burning pain with dull stitches in small spot of 1. chest, while resting. On ist d., eye-

lashes are covered with hard mucus in m. ; when reading, dimness of vision with flickering before eyes, compelling to wipe them frequently, which, however, makes it rather worse (also 2nd and 3rd d.) ; insipid taste in mouth in m. (ist days) ; increased thirst (do.); less frequent, scanty, hard evacuations (do.) ; increased urination, slight burning \a glans while urinating (do,) ; agitations and crawling in chest during rest towards e. ; violent pressive pain in chest on waking in m. (for 8 d.),also when waking during n. (first days) j under short ribs, mostly of r. side, throbbing pressure in small spot, especially during inspiration ; when bending head forward, first heavy pressure under upper part of breast-bone, changing gradually into violent bellyache ; shifting pains in chest ; burning soreness under sternum, especially when moving and drawing deep breath (also 2nd d.) ; painful drawing in finger-joints ; sluggish, with great inclination to offend and quarrel i buoyant feeling (first days). On and d., repeated painful drawing in forehead ; dryness of nares with discharge of a few drops of blood j sticky saliva in mouth (also 3rd d.) ; tough phlegm in throat in m. ; dryness and roughness in throat on waking in m. ; urine orangecoloured and pale, on standing it gets turbid, and forms a white precipitate on wall of glass ^ painful burning with repeated stitches in upper 1. chest, aggravated from rest. On 3rd d., throbbing pressure in anus after stool ; violent burning in 1. of abdomen when lying on that side, c. j soreness and stitches in small spot of 1. chest, e. ; strong throbbing and soreness in chest when bending forward, with giddiness when bending back again ; dislocative pain in r. wrist. On 5th d., almost constant twitching and starting of lower evelids, causing lachrymation ; dulness of eyes, with slight burning and lachrymation ; scraping and roughness in throat, with accumulation of tough phlegm ; agitation and tightnes* of chest, with flying heat in face and frequent pulse, p.m. ; compression of chest from both sides forward, e, (also 6th d.). On 6th d. pappy stool (also 7th d.) ; violent burning in I. chest, sitting, e. On 7th d., searching pain in upper abdomen, with flatulence and sudden peevishness and irascibility of temper, towards e. On 8th d., after supper pressive searching pain under scrob. cordis, with general malaise. On 9th d., shifting twitchings in different parts of chest. On lOth and nth d., startings in r. upper eyelid; involuntary micturition during dreams (having omitted to pass urine in e.) (loth n.). For some weeks, every time he drinks, copious urination.

e. Same took gr. v of powdered root. Immediately great nausea with retching and inclination to vomit. Soon after, giddiness with buzzing before ears; confusion in head; dimness of eyes; burning scraping in throat causing frequent swallowing. In ^ h. increased salivation. After ^ h., absence of appetite for breakfast ; irritation in throat causing slight coughing. In i h,, burning drawing deep in chest. In li h. increased salivation with astringent feeling in mouth. On i8t d., twitchings in eyelids; consunt twitching in r. external corner of eye; pressure in eyes, e. while light; burning in eyes while reading or writing; drawing in glands of neck; putrid smell from mouth falso 5 d. following) ; diminished taste ; increased thirst (first days); lessened appetite (do.); griping during dinner; agitations in

with dull stitches in it; chilliness with weariness in legs ; insipid taste in m. (first days) ; painful erections with increased sexual desire for first 2 d., diminished later ; oppression of chest, especially during rest (first days) ; violent prcssive pain in chest on awaking (first 8 d.) j while lying on r. side, dull stitches, with burning pain in 1. chest, e. ; pain in back (first days) ; very restless sleep at n., repeated awaking from dull stitches in chest with oppression (also for 13 d. more). On 2nd d. drawing in eyeballs with diminished vision ; cool feeling traversing ear repeatedly ; accumulation of phlegm in throat, with dryness of mouth ; hard scanty stool, followed by pressure in rectum. On 3rd d., pressive pain in forehead and orbits after dinner, especially I. side, relieved in open air; gnawing feeling of hunger under scrob. cordis in m. ; gnawing before dinner-rime in gastric region, without appetite (also 4th d.) ; feeling of obstruction in upper part of lungs, especially on walking fast ; jamming pain in dift'erent parts of chest (also on 4th d.) ; dull shifting pressing pains in chest, with tightness of it, impeded inspiration, frequent chilliness down back, and intermittent pain in several small spots of head ; gay but irritable and irascible (also 4th d.). On 4th d. headache relieved by cold ; itching on scalp. On 5th d. confusion of head, with pressing and dulness of eyes ; swelling, burning, and pressure in eyelids, without much redness ; restless sleep full of dreams (also 6th and 13th n.). On 6th d. violent throbbing headache, with pressure in eyes, diminished appetite, bruised feeling, and general malaise; tearing and drawing pains in temples down to face ; pressure in eyes ; pappy stool (also 7th d.) ; frequent and increased urination ; urine gets turbid and throws down a reddish deposit mixed with mucus ; febrile movement, chilliness down back, heat of face, dull burning eyes, throbbing headache, difficult respiration, stitches in chest, general bruised feeling, frequent pulse (also 13th d.). On 8th d. a stye forms at margin of r. lower eyelid, with throbbing there ; lachrymation, especially of r. eye, in open air; hypochondriacal mood, irascibility {also 9th d.). On 9th d., burning pain in small spot of 1. chest, with fitful mood, p.m. (Staff's Bcitrdge.)

1. Same gave i dr. of tinct. to a young sensitive woman. Soon after, burning scraping in throat, inducing frequent swallowing. After

I h, painful pressure in eyeballs. In first days, annoying dryness in nose; constipation. On 2nd d., burning pain in I. chest, with feeling of great anxiety in it, e. On 3rd d., great dryness of throat, making speaking difficult ; a bright spot repeatedly appears on the wall sideways from eyes, at noon, which when looked at straight disappears ; drawing from chest into axilla. [Ihid.)

1. ff. A young, slender, weakly man took 10 dr. of tinct. Soon after, heaviness of whole head, lasting 6 h. In |^ h., reeling sensation in head ; pressive feeling in forehead, lasting i h. In i h., dryness of mouth, then increased secretion of saliva (extraordinary dryness of mouth and larynx, in m, and forenoon, lasted many d.) ; general weariness, especially in lower limbs. In 3 h., burning under sternum extending to back. For first 4 d., pressive pain in scrob. cordis ; repeated sneezing ; repeated slight cough produced by increased secretion of mucus in larynx, especially forenoon in open air and walking fast ; pain

in chest for \ h. after smoking a pipe (as usual) in afternoon ; repeated pressure under sternum } roughness in throat aJmost t hoarseness, forenoon. On 3rd d., great weariness of legs, especial! forenoon.

b. Same toolc 15 dr. After ^ h., confusion of head. After i h, headache, especially towards forehead. After i^ h., feeling of sor« nesss in throat, lasting 3 d. After 2 h., tightness in I. chest, amounM ing almost to prcssive pain. During first 6 d., weariness am frequent yawning ; increased secretion of mucus in throat, causin slight cough, lasting 3 weeks. Constipation till gth d., then increase dcfsecation for 2d. Hacking cough in open air, lasting about 3 weeki Oppression of chest, with slight fugitive pains through it towardl shoulder-bladeSj during first 10 d. at irregular times, especially in open air and when walking.

c. Same took 2 gr, of powdered root. After J h., confusion t head. After ^ h., pain in occiput, extending later to temples, finall to whole head. After 2 h., painful pressure in orbits. On 2nd, 3n and 4th d., micturition more frequent, but smaller quantities passed 1 the time, urine pale in colour. Sleep interrupted several consecutiv n. at 3 a.m. by pressive almost crampy pain in stomach. (Ibid.)

1. A robust phlegmatic man took 15 dr. of tinct. In ^ h. tensil feeling from palate to articular cavities of lower jaw ; scratching i throat, necessitating frequent hawking and empty swallowing -, sligt boring pressive pain in region of heart, apparently superficial. In ^ hi dryness in throat, with fugitive stitches, especially in uvula ; repeated deep inspiration; somewhat hard frequent pulse i anxiety, with some what frequent respiration. In | h., too great susceptibility of eyes fi( light; violent pulsation of heart, shaking whole chest. In I h., prcs sure over 1. eye ; fugitive stitches (superficial) in intercostal muscles t lower r. ribs. In J^ h., dryness of eyes, with feeling as if eyes wei too large for their sockets ; flickering and swimming of letters whi reading ; painful sensitiveness at hearing tunes he otherwise liked weariness and slight trembling of upper limbs. In ij h., annoyin dryness of mucous membrane of nose ; dryness in middle of tongui without fur; inflammatory swelling of whole of fauces, especially < uvula ; slight pressure about sacrum ; great weariness of body, wil stretching of limbs, confusion, heaviness and throbbing in head. ] 24 h.j smell as from a bad ulcer; secretion of whitish tough phlegi in throat ; metallic taste ; rumbling in bowels ; boring pressive pain i whole lower chest, especially over region of heart, lasting some time« pain in back ; tensive soreness of joints, especially those of foot an knee. In 3^ h., trembling of objects looked at for a long time, wit lachrymation ; white fur on tongue; hawking and empty swallowing slight pressure in region of heart, with oppression and difficult breati ing, while walking, In 5 h., burning pain in whole length of urethl while urinating ; boring pain in region of heart. In 7 h., increase salivation. In 10 h., flickering before eyes with dulness of vision fr continued reading and writing; boring pain moving about navel, also chest ; tearing pressing pain along base of I. scapula ; painful feelings hip., foot-, and knee-joints as after a long journey. In 1 1 h., thi

with dryness of throat. After 15 h., frequent discharge of greyish urine, forming cloudy deposit, though he had not drunk much. In e. of 1st d., violent pressivc throbbing pain in forehead ; boring pain in 1. hypochondrium j melancholy mood ; tickling and scratching in throat ; dry cough with oppression of chest and roughness in throat ; entire absence of appetite this d. and the two following. On 2nd d., secretion of much mucus in glands of eyelids ; dulnessof eyes while reading, lachrymation after straining them ; increased micturition with pressure in urethra ; urine turbid, cloudy when cold, m. ; stitches along urethra after passing dark yellow urine, m, •, cough with tough expectoration ; pressive boring pain in chest, fixed in region of heart, radiating thence to 1. axilla. On 3rd d. much thirst, with roughness and dryness of throat (also 6th d.) -, pressive boring in circumference of 1. chest, especially about region of heart ; violent burning and itching under skin of whole back, especially between scapulae (also 6th d.). On 4th d., formication in eyelids and feeling as of sand in them ; tensive pain in eyes^ with too great sensitiveness to light ; roughness and dryness of throat, with dry cough ; pressure and burning at urinating in e. (also 6th d.) ; thorax seems too narrow; violent pressive pain all over chest, especially I. half, whence it seems to proceed. On 5th d., urine is at first mixed with mucous threads, after getting cold it is quite thick and cloudy ; burning while urinating in m., with feeling as if urine had to force its way through urethra. On 6th d., colicky pain in gastric region towards noon ; m. urine after cooling gum-like, lower stratum of its thick deposit is yellowish-red, upper is yellow, flocculenc, cloudy (also 8th d.) i painless dry cough ; tensive pain when taking deep inspiration in lower chest. On 7th d., pressing pain in region of heart. Without date, — unequal, soft pulse, 82. {Ibid.)

1. Doses of 40 — 60 dr. were taken by a young, slender man, of rigid fibre. In 2 h., sudden pressure in r. abdomen and chest, e. when sitting. On ist d., 3 easy pappy stools. On 2nd d., m. (24 h. after dose), thorax painful in front from touch and inspiration ; pressive pain towards eyes as if eyes would be forced out, ceasing after \ m., leaving dull feeling; itching between nates, relieved from scratching ; general sensitiveness or simple pain in walls of thorax, especially when touched, less perceptible when breathing deeply. On 3rd d., defaecation at first very difficult owing to thick dry fa:ces. A pressive headache, beginning in m., in sinciput and occiput, not aggravated from touching, recurring daily, mostly felt sitting in warm room, with pressure in eyes, which arc intolerant of being touched ; after dinner on 5th d. there was nausea and inclination to vomit, quietly supporting head seemed to alleviate, but more so exercise in open air ; there was slight feeling of diarrhoea, which did not occur ; after 1 \ h., when nausea had passed ofF, a not unpleasant feeling towards parotid gland, and superficial pain in region of heart. Without note of time, — pain in occiput ; when walking towards setting sun, another small sun seemed to float underneath, changing its shape to a flattened oval when lowering eyes, when turning head backwards and shutting eyes it disappeared ; painfully pressive sensation in r. ear when chewing; lower front teeth painful from breathing cold damp air through mouth ; slimy tongue in

m., with nasty slimy taste j slight burning at tip of tongue; biting burning sensation in palate, as if epithelium was gone ; warmth and oppression in gastric region during inspiration ; when rotating thigh while standing, felt dislocative pain in hip-joint. {Uid.)

1. One dr. of tinct. was taken by a strong lively girl, set. 15. Soon after, feeling of constriction in throat ; slight giddiness before eyes. On 1st d., pressure in r. eyeball ; slight prickling and fine stitching in cavity of mouth, with flow of saliva ; tightness of chest at various times (first days) ; slight burning in lids while writing. [Ibid.)

2. Ten dr. were taken by a plethoric strong man. Soon after, bad taste and some grumbling in stomach. During first hours, feeling of warmth in stomach ; some cutting in gastric region j moving and grumbling in stomach (intermittent) ; severe cutting from stomach to scrob. cordis, and on ist d. somewhat pappy stool with rumbling in stomach and i^atus, and increased acrid urine. Slight burning in glans during micturition for first days. [Ibid.)

lb. a, A strong robust man took 10 dr. of tinct. In 1 h., slight pressure under sternum, while sitting upright. In 5 h., feeJing of flabbiness in stomach, with water-brash. On ist d., spits more than usual in smoking, saliva quite watery. On 3rd d.,a vesicle size of pin's head in middle of margin of 1. upper eyelid, pressing and troubling eye; on being opened it discharged a clear liquid, and the pressure went off. After 4. d., increasing pappy and thin stools at irregular times.

b. Same took 20 dr. On 2nd d., strong pressure under middle of sternum while sitting, On 3rd d., dull feeling in r. forehead like pressure; fugitive tearing pain in I. forehead ; slight blowing in ears, which are as if blocked ; increased secretion of white slimy phlegm in windpipe, which he has constantly to hawk up; want of appetite; pressure in scrob. cordis and region of navel, pressure under sternum increases and descends to scrob. cordis. On 5th d., pressing in r. upper eyelid towards inner corner. On 6th d., both lids of r. eye inflamed and swollen, especially towards inner corner, with pressive pain.

t. Same took 50 dr. On ist d,, repeated hawking up of grey lumps of phlegm early in m,, with irritation to coughing in larynx. During first days, pressive pains in region of navel occur p.m., increasing in e., especially when at rest ; incitement to cough in larynx. On 3rd d., slight stitches in middle of chest, which ceased at once after a single deep inspiration. On 4th d., disgusting sweetish taste in throat, lasting several days. {Ibid.)

1. Nenning. (No report.) — Head feels heavy ; itching in nose ; vesicles with burning sensation in upper lip near nose and I. corner of mouth, itching when touched ; frequent spitting and running of saliva ; burning in throat ; scratching in throat and back of tongue, with accumulation of saliva (immediately) ; inclination to eructations; risings of air; want of appetite; nausea in stomach; emptiness in stomach; burning in stomach, finally retching and vomiting ; loud rumbling and pinching in I. abdomen ; urging in hypogastrium, and soon after discharge of flatus (after ^ h.) ; griping, after some h,, disappearing with diarrhoea ; increased micturition ; sneezing and tickling of nose ; gay and merry, and particularly in good mood for business. [Ibid.)

9»

1 8, June 3rd, 8 p.m., took 5 gr. cxt

\egx alcohol, aquos. dry, and drank some water afterwards, when a penistent scraping came on m fauces. Great discharge of flatus, and much eructation of tasteless 10 p.m., 5 gr., no flatulence. The urine passed at n. is darker frothy long after being passed. — 4th, 6.30 a.m., 10 gr. No sym- 2 p.m., 10 gr. immediately great pressure in r. temple. ^fLin., 10 gr. Great pressure in 1. ankle-joint and fauces for some 5 p,m., 10 gr. 9 p.m., 10 gr. Urine at n. scanty, dark, — 5th, |fe.50a.m., 10 gr. 8 a.m., 10 gr. 8.30 a.m., 10 gr. 9 a.m., nausea or 1 h. II a.m., copious liquid bright-coloured stool, it squirted out Df anut almost without sensation. Several times sudden pressure in [both temples, i p.m., 10 gr. 2 p.m., 10 gr. 3 p.m., 10 gr. No |ijTnptoms. (LEMBK.E, A^. Zeit.f. horn. Kl.y xiii, 161.)

1. SuNDELiN took 3j of powdered root every 2 h. for three doses. It produced a smart and unpleasant irritation of the posterior fauces ud throat, with copious flow of saliva. Soon after a decided burning was experienced in the stomach, which, after the 3rd dose, was replaced bv painful choking and a violent vomiting of thin mucus. The •kin, meanwhile, grew moister and warmer. Sharp colic ensued, and 1 iratery diarrhoea ; urine was at same time augmented, and scalded lomewhat when voided. For a d. or two afterwards there was gastric

I uneasiness, with loss of appetite. In larger doses it caused burning ! pain in stomach and bowels, violent vomiting, purging, giddiness, and Mxiety. (From Staff.)

1. a. BikKER took for 2 successive d. a considerable quantity of •decoction of S. root, representing 1 5 drm. of the root, and on the 3rd d. Swofthc powdered root, without any efl^ect on health. — April 22nd. Took jij of powdered root in doses of 10 and 20 gr. This caused KTifj feeling in throat for a considerable time. Then a contractive feeling in the lower part of thorax ; it was as if the scrapy feeling extended downwards to lower part of chest and upper part of abdomen. Pulie about 5 beats slower. — 23rd. M., on rising, bloody nasal mucus, the nose had evidently been bleeding during sleep, and he had swallowed the blood. Respiratory movements very strong, with rough feeling in chest. He then took 3iiss of the powder. In e. when he

JMnliced out he had slight coryza that lasted a iew h. The eyes felt ^ptif, and he had a tight feeling in chest. Nose bled at n. — 24th, same Biow. Some mucous discharge from nose, weakness of eyes, and the ^tight feeling on chest. — 25th, 140 gr. of the powder in single doses of

20 to 25 gr. This caused coryza of thin mucus and the tight feeling ^n chest. Slight cough with mucous expectoration. Eyes weak and ^Vatery. During this trial (he following constituents of the urine were HjMMtsed : the solid constituents generally, the uric acid, the earthy ^^Kbates, the volatile salts, and extractive matters of the urea. ^^#. In a second series of provings of the decoction the eyes and nose

were affected with catarrh, the eyes watered when he exerted them.

The following constituents of the urine were increased : mucus, earthy

phosphates, volatile salts, and extractive matter. *. In a third series of provings with larger quantities of the drug, : health remained unaltered. The following constituents of the

urine were increased : the solid constituents generally, the uric icid, the volatile salts and extractive matter and the urea.

d. In a fourth series of provings he found that the quantity of carbonic acid given off by the lungs was considerably increased, whilst (he number of respirations and pulse-beats was diminished. (Bociuk's Beitroge zur HtilkuncU, ii, 20.)

II. Poisonings, — i. A man labouring under severe rheumatism was ordered to take at intervals a decoction of ^j of the root in Oj of water. He drank instead the whole quantity at once. The consequence was the most violent vomiting and purging, which lasted all the next n., accompanied with profuse diaphoresis. (Bigelow, Jmtr. Botany^ ii, 103,)