Onosmodium virginianum

Volume IV — Appendix

ONOSMODIUM.

OnQsmo,lium virginianum, D.C. Nat. Ord., Boraginea.

third

the

I. Provingi.—i, Dr. W. E. Green. (This is the third provini have made upon myself, and there is no essential difference in the cfl Oct. ist, 1884., 7.30 a.m., drank of water 6 fluid ounces; 7.4S> a" breaicfast, coi •listing of broiled steak, 2 ounces; potatoes, 3 ounces; eggs^ 1 ounce; bread, ounces; butter, ^ ounce; syrup, 4 fluid drachms; coffee, 6 fluid ounces; water, fluid ounces. 10 a.m., drank ot water, 8 fluid ounces, and ia.30 p.m.,6 fluid ounn Ate dinner at i p.m., consisting of roast meat, x ounces ; potatoes, 3 ounces ; dia tomatoes, 3 ounces ; bread, 3 ounces ; butter, J ounce ; water, 8 fluid ounc* 4 p.m., drank ? fluid ounces of water. Ate supper at 7 p.m., consisting of hroili steak, » ounces ; potatoes, 3 ounces ; eggs, i ounce ; butter, J ounce ; bread, , ounces; syrup, 4 fluid drachms; milk, 8 fluid ounces; water, 6 fluid ouncq 9 p.m., drank 6 fluid ounces of water. During the o.^ h. passed i% fluid ounces d dark ^traw.coloared urine, of natural odour, slightly acid reaction, and toi6 sp, ^ ind. — Observed same regulations as yesterday, and so throughout proving. T<mIiJ passed ij ounces of dark straw-coloured tirine, natural odour, sliently acid reactiof* and io»7 sp. gr. 3rd. — Am feeling very well this m. ; slept well last n., and attmj breakfast this m. with usual relish, BowcK anil kidneys acted naturally ; tongu* clean; skin moist; pulse 71, and normal in volume and regularity; terapcniur* 98'6°; vision in both eyes ^; fundus oculi normal ; hearing in r. ear JJ-; 1. f*'i^ 9 a.m., took 60 min. of tinct. Within 10 m. commenced to feel sensation of fluni*; ncss and weakness in legs from knees down to fett. 9.10, dull, heavy pain in fiwii* region and in both temples, aho in mastoid region. Slight sense ot intoxiriiiiXi dazed and uncertain feeling of mind. There is uncertainty of action. Have to«i»I to think whether or not I am going right or doing the right thing. 9.J0, ''Z nervous and tremulous; my hands tremble so that I can hardly write, usually my lun>»! are very steady. Pulse 84 and regular. Increasing secretions in mouth and ihtirt Have a feeling of lightness about me, something like that experienced when tittii chloroform. Slightly flushed feeling in face. Decided forgetfulness ; will sort td say something, and before the sentence is finished will begin to talk on some otW subject. Quite talkative, but in a disconnected way. Dull pain in mastoid rtgiool Sharp darting pains in I. temple. 10, am very forgetful; started to get into O] buggy, but before I reached the door I forgot where I wis going, and went 10 «»n other part of the house ; I forget everything. Am very restless, constantly moMfl about without cause or reason. The movement neither aggravates nor T«licif«» B symptoms. I write very fast, with all my might, hut cannot keep pace with a thoughts. Before one sentence is completed will begin upon another. 1 ora" and leave out letters. In writing or talking I cannot concentrate my fl 10.15, darting pain in 1. temple. Slightly blurred vision ; feeling of tension want to look at far-off objects. Numb, tired feeling in popliteal spares, worse Tired, wearied feeling in limbs like one feels when ju3t getting up ffom a ipell sickness. 10,30, very impatient ; can't go fast enough ; my team traveK too tlu have not the patience to let them walk over the rough places in the road. Dull | in top of eyeballs ; a feeling of tension in eyes as when straining them 10 read n print. Want to look at things very far away. It i» not pleasant to look at objects. Want to keep the eyes very wide open. The eyes feel as if ihry v»eic t wide open. 1 1.30, felt as if I would have a chill. This symptom continued to o every d. at about u or i o'clock for several d. after I stopped taking thr tnedl Pain in r. frontal region and dull pain through temples. Pulse 66. 1 a rn., ! 60 min. ; soon after had darting pains through r. malar bone, and numh 12,10 p.m., tired feeling in forearms and flexures of elbows. Aching in elbo«< wrist.joints. Shooting pains in phalangeal articulations of 1. hand, DisagrM

tir

tking all over, as though I would have a chill, i p.m., took 60 min. My restlessoti» hai subsided, and I feel sluggish and dull. Feel better when lying down. Dtyncsi of mouth and throat. Clammy, sticky feeling in mouth. Ate dinner at I " ■>' with usual relish, My symptoms were all temporarily rtlievcd by eating, ■J tired k'eling in limbs. As I walked to my office, I experienced dull aching >f 1. leg. Disagreeable numb feeling in 1. forearm and leg, worse in leg. tu of mouth and pharynx. Slight laryngeal cough, with gluey, sticky expecto. »,jo, feel very drowsy and stupid, j, took 60 min. J. 30, mind is dreamy mJ in a itate of apathy j cannot think. No pains, only a weary feeling pervades tntirt body. Pulse 66. 4, mouth and throat very dry. 6, took 60 min. 6.30, nnich depression about heart, as though it would stop beating. Pulse 66 and weak. Ocasionally the diastole seems prolonged. In going to my office this e. my legs felt ">«tary and unsteady that I could scarcely walk. Have perspired very little to-day, igh the weather has been exceedingly warm. Ate supper at 7 with very good 7.30, felt so tired that I was compelled to lie down. Slept for one h. and iinkeiied much refreshed, all my symptoms alleviated excepting the mental lethargy. ••30, diffuse colicky pains in abdomen below navel; a general bellyache. Time temj to pass very slowly ; minutes seem like hours. Have no re.solucion to do anything, I have been sitting here for an h. trying to write a letter, but have not yet Miir ] beginning. Vague, listless, and indifferent thought occupies, my mind. My nn iiQg, and my head feels light, as when taking quinine. Constant laryngeal :h. Uneasy colicky unsation in lower abdomen as if diarrhcea would come on. Went to bed last n. at 11, slept well all n. and awoke at 6 a.m. I feel this ■n.iore and tired as though I bad done a hard day's work. Have an annoying laryngeal cough, with white sticky expectoration. Pulse 66, irregular and weak. Sexual ■loire much impaired. 7 a.m., took 30 min,; ate breakfast, but with little relish, I wuld not eat my steak. Had a soft mushy evacuation at 8. During the past 24. h. 'psed »i fl. oz. of dark straw-coloured urine of highly acid reaction, normal odour, 'P' gr. 1017. 8.4.0, 1 do not feel well this m, 1 am slightly nauseated and have a Jlammy disagreeable taste in my mouth, also an unpleasant feeling in stomach. In "", F feel sick all over. Have a depressed feeling about my heart as though it would ''"P beating. Pulse 81, rather full and slightly irregular. Am very restless this m. ; f">t>or be still i am constantly moving about, Time pas.ses very slowly. I have no ~*'dache this m., that left me yesterday afternoon ; and, until recently, not so much *•' the numbness and weakness of legs. Have had some eructations during m. 5,30, '^•''y numb feeling in legs and popliteal spaces, deep-seated. 10, 30 min. Con- ^*it dryness of pharynx and post-nasal passage, with frequent efforts to clear them, ^lectorating a small quantity of white sticky secretion. Have a feeling of fulness, •■ a stopped-up feeling, in ears. Hearing is much impaired. H. d,, r, ear = -JL j J, ■ = ^. Vision in both eyes ^ ^. Optic disc hyperaemic and retinal vessels en. gorged. 1 p.m., 30 min. Have had nervous sensation of hunger in stomach all d. ♦ and 7, JO min. Ate supper at 7.10, but had no relish for it. Have had colicky t'^nt and a sick nauseated feeling all e. Much disagreeable belching since supper. ''•tKiomen feels distended and bloated. The colicky pains are like those produced by **'"«t-»king largely of ice water. ;th. — Went to bed last night at 10.30, feeling very '''tary. Sleep was much disturbed by frequent awakening. Have a general tired l^^dinethis m., as if I had done a hard day's work. My sleep did not rest me. Sore ^0« feeling across small of back. Have slight hacking cough, with tough, sticky, ''»«te expectoration. Ears feel as though I was suffering with catarrh. H. d.,r. ear ^^ Wi '-'^f^H' I usually pass water very often, and several times during n., but *»«<:e 1 have been taking this medicine I do not get up at all during n., and only *yujte the bladder j or 4 times during the 34 h. In walking this ra. I had a general ^^^d, sore, and lame feeling. During the past »4 h, I passed 10 fl. ox. of brown- oared urine, of balsamic odour, highly acid reaction, and sp. gr, lojo. It was **vily loaded with urea. 7 a.m., 60 min. 9, much oppressed about heart. Pulse . ■♦» and rather weak. Much dryness of throat and nose. Weary, numb feeling in ^^e» »nd legs. Tingling in calves and feet, most marked in 1. Am quite nervous _^^ tremulous. Very restless. Bowels moved at usual hour ; action yellowish, soft, ^^^ itjushy. 10, 60 min. H. d., r. ear = ^ j 1. ear = ^. i p.m., 60 min. Much 2^J'>e»sof^mouth, throat, and nose. Constant naso-pharyngeal expectoration. Pulse The system seems to become tolerant of the remedy, and, excepting the deafness,

I seem to be much lew affected to-day. +, 60 min. My tymptomi hiu ill been modified to-day. 9, 60 min. €th. — Was quite restless last n., aiul «wk( rather early this m. Did not relish my breakfast. Pulse 84. H, d.,r. tar = ^^» 1. ear ^ M- Much depression about heart. During the J4. h. 1 px<^scd sjll. cts, of dark urine, highly acid, andsp.gr. 1030. Bowels moved same as yesterday; uin« character of stool. 11 a.m. and i p.m., took ^ij. 1.15, pulse io> and full. Facr' feels flushed and swollen. Ears feel stuffed and full. Eyes feel ten«e ; vision blurrcvl Disturbed co-ordination of muscles of legs in walking. Lips, mouth, thniii in nose feel very dry and parched. Sore scraping sensation in rhroar, momentarily relieved by drinking cold water. Crave cold drinks to relieve the dryneti, b^^H not specially thirsty. 3 and 6 p.m., repeated dose. Have had rer]' dry 'h'^f^^l mouth all d. Throat perfectly dry and stiff. Very full feeling in head antf^^H Skin dry. No perspiration, though weather i« exceedingly warm, H. d., r. tar:^ JL ; I. ear = ^. Vision blurred. Vision in both eyes= -f^. Optic disc hypcmni^ retinal vevscis engorged, worse in I. eye. Bloated distended feeling in abdontefl Pain and stiffness across lumbar region. 7, pulse 90. General feeling of diitrrt and fulness in entire body. Dull, heavy, frontal headache. Pain in both mwo regions. Legs, from knees down, feel very tired and -weary. Aching in knti Am very drowsy and dull, and very forgetful. Ate supper at 7.30, which relicv throat considerably, 8, have much colicky pain in bowels, and feel as if diarrhol would come on. I am quite sick, tired, and weary to-night. 7th. — I paoed 1 tr* less, sleepless n., and awoke very early this m., suffering from dull occipiW-tTont headache, and a tired, sore feeling all over. Was hurried out of bed to stool. Hi a soft, yellowish or greenish, stringy stool ; urgent, and accompanied »vith muc tenesmus. During the last 14 h. I passed 17 fl. 01. of very dark urine, highly ir« and lojo sp. gr. Have a very tired and numb feeling in popliteal spaces, and « ing in knees. My legs feel as though they would not support the body. Pttl<* ^ weak and irregular. Decided naso-pharyngeal catarrh, with constant acrumuluic of white, sticky phlegm. H, d., r. ear =: ^ j 1. ear = /g. Vision in both eyei ^ ff 9 a.m., passed a small, greenish or yellowt«h, stringy stool, intermixed with ijiuort and blood, and accompanied with tenesmus. I feel very badly in general thit tOt Am tired and stiff all over. Legs and knees feel tired and numb, and biccp»«»' muscles of forearm feel sore, as when overworked. I have felt all the m. a it I would have a chill; am also very restless and nervous. 8 p.m., have felt ill e. U, though I had been taking quinine. H. d., r. ear = ^ ; I. ear = |-|^. Vision in r. nt = Ag ; in 1. eye = Jl,. 8th, — Slept well last n., and relished breakfast this m. PoM 84, irregular. Passed during the 14 h. 13 fl. oz. of dark-coloured urine, highly aoJi and 1015 sp. gr. H. d., r. ear = ^1 ; !■ ear =: L|. Vision much the same as II a.m., return of weary numb feeling in legs and knees ; also feel decidi but not so much as yesterday. Had one soft, yellowish, mushy stool. 9tb' well last n. Puke 80, irregular. Depressed cardiac feeling almost gone. I car =: ^ ; 1. ear = ||. Vision in both eyes = ^. Disc and retinalvessels ia r. c) normal; disc yet slightly choked in 1. eye. During the past 14 h. passed 45^. 4 of straw.coloured urine, reaction neutral, normal odour, and sp. gr. 1019. Sexualden has from the first been almost entirely obliterated. Cardiac oppression existed thiw^ out. (HaA/i. MontAlj, June, 1885.)

a. a. Mrs. C — , zt. 30 ; brunette ; has always enjoyed good health; appetite good bowels inclined to constipation; pulse 75 and regular. March aoth, 188$. cm mcnced taking O. at 8.30 a.m., and took one teaspoonful every j h., until 4 d< were taken each d. Fifteen m. after taking first dose my throat began to feel sort raw,and it hurt me to swallow. These symptoms were rapidly increased after taki second dose. During afternoon the soreness subsided on r. side, but continued a At J.JO p.m. I commenced to have dull feeling about head ; aching in front, w« over 1. eye. My throat is growing worse j it is a dry, raw, sore, rough feeling, 1 pains me severely. There is slight accumulation of white, sticky phlegm that Ite me constantly clearing my throat ; throat is stiff" and voice is husky. Soon il taking last dose at 5.30, head began to ache severely in I. temple and over both ej worse over I. I experience same sensation over bridge of nose, I am s ery dull aleepy. aist. — I slept well last n., but had many dreams that were in character, and awoke this m. feeline very tired. I had but I break fa-st. Soon afte

ing

8.3c

bc^an to fct dry, Mire.

and the tame sticky mucus began to appear. Head aches in front and back, and I have sharp pain under 1. breast. Ourin? forenoon bowels have been very much bloated, and the distension has distressed me. I have also suffered vritb severe colicky pains, mostly in lower part of abdomen. Loosening clothing and lying down upon back afforded relief. I am forgetful, and mind seems confused. I have a tired feeling like one who has been sick, or is exhausted by long watching | this weariness is most marked in lower part of back. Soon after taking third dose, at 3.30, head began to ache over both eyes, and I became very nervous and restless, tremulous and impatient, with constant desire to move about. Later, I became dull and drowsy, mind confused and body extremely enervated. I do not want to move, but sit in a dreamy, listless mood. My breasts feel swollen and sore, with itching about nipples. When I walk I have pain low down in back. 4.30, 1 have just slept an h., and find all my symptoms gone on awaking ; they soon return, and are again relieved by going into open air. After taking fourth dose, at 5.30, my symptoms were aggravated in about the same order of recurrence. Eyes feel tired, and as though I was stretching them wide open. Lids feel heavy, as if I had lost much sleep. I nave passed a small quantity of nighly coloured urine twice since early m. I have had but little thirst to-day, much less than usual. 8.30, throat is still sore, and head still aches, aand. — I went to bed at 10 last n., but could not sleep on account of severe pains low down in abdomen, like those produced by taking cold during menstruation. The same pains awoke me this m. I took my first dose at 8.30, and in a few m. became very nervous ; my hands tremble, and I am restless. My head soon began to ache, and a listless feeling of mind came over me. I find myself gazing at objects across the room, and am completely lost in imperfect thought. I do not wish to talk or make any effort. I have been sneezing a great deafthis m., and 1. side of nose and 1. eye seem to be affected. Throat is dry, raw, and painful, and voice is husky ; and there is constant but scanty accumulation of white, sticky mucus in throat. At 1.30 I was taken with pain in 1. hip. M^ back has ached severely this afternoon, and I have suffered from uterine and ovarian soreness, bearing-down pains, and engorgement of breasts, sjrd.— I slept well last n., but sleep was interrupted by dreams. At 10.30 I had pain in bowels, caused, I think, by gas. My bowels move every d. ; before taking the medicine I was constipated. Soon after taking dose at 8.30 I began to sneeze ; grew nervous and restless ; then head began to ache, and throat got dry and tore. During forenoon head has ached throuzh back and front, and over eyes, mostly over 1. Head and eyes confused. Pains in 1. breast from nipple through. Severe, heavy, bearing.down pains in womb. Sharp cutting and throbbing pains, also dull, heavy, aching, and slowly pulsating pains in ovaries ; pains begin in one ovary and then pass to other, leaving a soreness that lasts until pains return. The uterine and ovarian pains are increased by external pressure, by walking, and by the pressure of the underclothing ; I had to remove the corset. These pains lasted for many d. A general soreness in lower part of abdomen. Lips and mouth are dry, and yet I have no thiist. I am vciy drowsy, listless and dull. When I give up to this feeling and sleep I am better. Going into open air also relieves me. 24111.— I slept well last n., but dreamed much. Soon after taking the medicine I had return of same nrmptoms, in about the same order as yesterday. During d. I have had mat distaste for water, and but little appetite. Have had nauseous belching, colicky griping pains, rumbling in bowels, bloated abdomen, and depression about heart. a5th. — Dreamed much last n., and was frequently awakened by uterine and ovarian pains. Am veiy sore this m. through lower part of abdomen. I have a general Keling as though menstruation would come on ; back aches severely, and breasts are •swollen and painful. Have a general tired and exhausted feeling all over; am nauseated, sick and nervous. Have much colicky griping pain ; distended abdomen ; rumbling in bowels and belching ; much leucorrhoea, whitish, yellowish, and exco. riating, causing itching made worse by scratching. Urine scanty, highly coloured, and voided frequently. Depression about heart ; pulse rapid and irregular ; pain in region where heart beats. This disturbance about heart makes me apprehensive lest I should die. Soon after taking first dose, nervousness was increased, and, within 15 m., head began to ache in front and back, worse through temples and over eyes. This was soon accompanied by sneezing; sore, raw, and dry throat s busKy voice, and pains in back, womb, and breasts. Am very drowsy this afternoon; have aching in 1. side of head and over I. eye. Distended abdomen.

have to loown my clothfi ; colicky pains ; belching and naus«a. Frt<ju«nt dnire urinate, though there is but little passed. Depression of heart. Weary Jteling after a long spell of sickness*. Pains over hip-bone of 1. side. Tired, weiry, anumb feelings in legs, knees, and hands. My legs feel weak, and tremble asthouj they would not sustain my body. I stagger when I walk, and cannot u»e my hii» well, they are so tremulous. I have pains in finger-joints. These symptonw h^ attended roe, more or less, throughout. I have nad no thirst to-day and but lit^" appetite. After caking last dose, I had flushed face>and full bloated feeling all over 3 am very nervous and tremulous ; cannot hold my book, or control my musdn •* walk or to write. The least exertion causes great tremulou«ncss. I am alio rtstler^ and forgetful ; will start to do one thing, and do another. Cannot get things righ • started to go into the dining-room, and went upstairs. These symptoms usually trS in m., and soon after eating a meal. i6th. — Have had about lame symptoms lo.cl^ ^ as yesterday. Am much depressed in spirits. I feel as though something terrik^ 1 was going to happen, and I am powerless to prevent it. My bowels are inclined -^^ looseness. I took the la.st dose to-day.

b. In a former proving'of the drug, the symptoms were somewhat dissimilar. Th I took smaller doses, and continued the drug for more than three weeks. When commenced to take it then, I was suffering slightly with ovarian pains. These ire allayed upon first taking the drug, and a degree of sexual feeling was excited. Aft taking the drug for a few days, the ovarian pains, accompanied vriib uterine pari and severe, excoriating leucorrhoea, reappearea, and the sexual feelings were entireextinguished. This time the ovarian and uterine pains, with the sexual p, were developed at the beginning, and gradually increased to the end. symptoms have been most severe and almost unendurable. The pains in my womb, ovaries, and breasts continued unabated for several d., until my meastruatic? came on, which was too early and for one day very profuse ; then it almost stopper* Before, it came on 4 d. too early, was natural in character, too profuse, and (ast^ too long. This condition of irregularity lasted for several months. During the lit"* stages of the former proving I was much more ner\ous than now, and had much ler control of my muscular movements. The Icucorrhoeal discharge was aUo wor's- There were other differences, mostly in degree, which I cannot enumerate. (M^.^-'