Xanthoxylum fraxineum

Volume IV — Main text

XANTHOXYLUM.

Xanthoxylumfraxiiuum, Willd. Prickly ash. Nat. Ord., XoMtAojtyUcM.

I, Provings.— . a. Mr, S — , xt. 29, light hair, nervous temperament, took at 10 p.m. 4 dr. of tiiict. Immediately a smart pepperir taste in mouth and fauces. Slept well all n. 2nd d. — Took 10 dr. in m., followed by same sensation in mouth and throat, which soon extended to stomach, followed by increased pulse and slight heat all over body. In 5 m. a dull ache at root of nose: in 15 m. sharp shooting pains in r. side^ like pains of pleurisy, occasionally extending through to scapula, which increased in severity and lasted \ h. ; durins this time there was constant desire to take a long breath. In 1 h. duU pain in r. ear and articulation of inferior maxilla of indefinite character, lasting 2 h. and gradually ceasing. 3rd d. — No symptoms recorded. 4th d. — Took 12 dr. at 8 p.m., followed by dryness in both nostrilsi

iUtti

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constant desire to take a long breath ; gaping ; flatulence ; \ h. later throbbing headache over r. ejre, with nausea ; sharp pains in r. side ; Kwre pain in r. arm, beginning above bend of elbow ; severe pain in wrist, extending to thumb ; in | h. ringing in ears, r. particularly ; throbbing headache } pulse 100. Slept hard all n., and woke languid uid depressed, without appetite. 5th d. — No symptoms recorded. W> d.— Took 20 dr. at 3 p.m. In 5 m. severe front^ headache, with iic^ess i continual desire to take long and deep inspirations ; nervous Wng of fear ; head feels full ; pain over r. eye and in r. side, sharp and ihooting } watering of eyes and nose ; constriction of head, with in- CRasingpain over eyes. In 15 m. increased desire for long inspiration ; Batulence ; pain in r. arm and r. knee. Drowsy all e. Urine at n. ud next m. scanty and high-coloured.

i. Six weeks later, at 8 p.m., took 25 dr. ; almost immediately felt Kne desire for deep and long inspirations ; in 5 m. pulse 100 } frontal l^odache ; nausea; 25 m., pulse still 100, but more feeble ; i h. later pulie 82, finble and irregular. (Hale, JNtw Rtmediti., 2nd ed.)

1. Mrs. A — , set. 27, dark brown hair, fair complexion, phlegmatic *'Dperament. ist d.— Took 3 dr. at bedtime. Slept hard and heavy, '"eatned of flying about over tops of houses. 2nd d. — In m. felt pam " f. leg ; bowels constipated j took 3 dr., felt sleepy all m. ; great ^Pfession; after dinner felt a bunch in 1. side of throat when swal- "^'ng J after supper discharge from bowels ; on going to bed the bunch "fted to r. side. 3rd d. — At 6.30 a.m. took 5 dr. ; in 15 m. discharge >in bowels, — ^also after breakfast j sleepy feeling all d., with head- ''c. 6 p.m., another discharge from bowels j flatulence ; slight ^ing cough. 4th d. — Took 12 dr. at 8.30 a.m. Strong peppery l^ation in mouth and throat ; 5 m. after had daning pain under and ^*nd r. ear ; r. nostril seems filled up ; sensation of soreness in r. side ^hroat J 15 m. after, darting pain in 1. temple, recurring again and ^n ; aching in upper half of head, accompanied by flashes of throb- 's pain as if top of skull were about to be lifted off ; flatulence ; »Qt pain above inner condyle of r. arm ; i h. after, sense of constric- 'I) about chest, with inclination to gape. At 10.30 p.m. pain in r. side ^ow ribs ; continued gaping ; head dull and aching ; a flash of pain in ^humb, extending to hand ; another in calf of r. leg j legs and feet *1 tired. 5th d. — Discharge from bowels before and after breakfast; ^reness of throat, with expectoration of tough mucus. {Ibid.)

2. Man, act. 33, light complexion, sanguine-nervous temperament, ctive habit, uniform health, ist d. — Took 2 dr. tinct. Burning and 17 feeling in mouth and tongue ; diffused pain in upper part of foreead, worse on r. side ; pain extends to base of brain, with soreness ; taking the head produces a feeling of looseness or quivering of the ain, followed by dizziness; rumbling of abdomen, with soreness on essure ; discharge of mucus from nose and feeling of congestion as if were about to bleed ; dull, heavy, grinding pain in 1. eye ; feeling of Iness and pressure at epigastrium ; empty eructations with slight taste

ingesta. 2nd d. — Slept soundly without dreaming. Soon after iking at 7 a.m. had severe griping abdominal pains ; thin brown diaroeic discharge, mixed with some mucus ; anorexia, could eat but a few

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mouthfuls at breakfast, and could drink only a half-cup of coffee, which was vomited soon after. Griping pain continued at intervals, witi general feeling of indifference and malaise ; discharge of dry and bloody scales of mucus from noise. Hoarseness, with husky feeling in throat, obliged to clear the throat frequently. The hoarseness and obstruction of throat continued some d. after other symptoms had subsided, {Ibid.)

1. Miss D — , act. 26, black hair, active habit, good health, istd. — Took 12 dr. of tinct. In 5 m. felt pressure in head, with fulncssof veins. In 10 m. dull pain in r. knee. In 15 m. pain in both elbows and back of head, with bewildered sensation ; pain in lid of r. eye. 30 m., sense of heat ail through veins, with desire to be bled ; flash oP heat from head to foot, i h., pain in ankle ; flash of heat ; pain in I. heel j feeling of enlargement of throat ; pain in r. side of throat; dull pain in 1. elbow, passing to palm of hand, thence to shoulder; pain itt. i. side } heavy feeling in top of head ; pain in 1. leg between hip inA knee, and in various other parts ; feeling of numbness through whofe of 1. side of body from head to foot, the division very perceptible ir» head, where it affected half the nose — this feeling lasted 2 or 3 m - 2 h, after, pain in I. knee, very severe, lasting more than i h. ; slight pain in 1. side, under scapula, and in 1. hip ; pain in lower jaw; whol^ I. arm and shoulder numb ; pain in both feet, shooting up to kn«»- {Ibid.)

2. Mrs. H — , net. 30, took 10 dr. tinct. at 6.20 p.m., pulse 8^«— Soon after, feeling of weakness and depression ; weakness of loarr*" limbs, with pain in knees. At 8,30 p.m. pulse 74, soft ; slight nausea with sense of oppression at stomach. Nausea and pains in limbs in^ — creased, accompanied by frequent chills. 2nd d. — In e. took 20 dr. w_ did not experience so much depression as before, but same amount om weakness of limbs and pain in knees ; pain in 1. side ; menses appeireo next m., a week before usual time, attended by a good deal of pain. (Ibid.)

3. Mrs. J — , JEt. 28, light complexion, sanguine temperament, good health. Took 20 dr. tinct. at 8 p.m. In 20 m. tightening <rf scalp and heavy pains in temples, with twitching in 1, knee and trembling in r, 2nd d. — Took 20 dr. at 11 a.m.; same sensations in head; did not notice lower limbs. 2 p.m., took 22 dr. ; same head» ache, or severe pain and constriction. 3 p.m., took 25 dr. ; increase 0' head trouble, and a quiet menstrual flow, being 2 d. in advance of usual time. 8 p,m,, took 20 dr. ; some headache j all the system quiet, with an unnatural forcing of nature ; went to sleep as usual, and awoke in dreadful distress and pain, baffling description; profuse flowing; pain (or agony) continued until noon of next d., when it graduaiW subsided. (Ibid.)

7, a. Myra de Normandie, Oct. 19th, 1884, being in perfect health, at 7 p.m. took 20 dr. Immediately intense burning and stinging in oesophagus, with slight nausea. In 20 m. decided dyspncra, with slightly increased action of heart. Slept as usual during n., but was waked at 4 a.m. by intense frontal headache. 20th. — Took 30 dr. Headache increased, of a burning, pressing nature, worse from moving

Hnd suddenly ; extending into vertex and orbits, with feeling of heavi-

DOS in eyelids and bright spots before eyes. Dyspnoea again noticed,

with occasional hot flushes over face and head. 12 m. — Headache

intense ; no appetite ; face much flushed. Temperature and pulse

normal. 4 p.m., pain and stiffness in nape of neck, somewhat relieved

by hard pressure or throwing head back, g p.m., 60 dr. Dyspncea

igiin marked, almost immediately on taking the drug, only lasting 8

or 10 m., during which time it was almost impossible to get a satis-

' tory inspiration. Noticed faintness at stomach, as if I had been

iting, but when food was brought cared to eat only a few mouthfuls,

which nauseated me. 21st. — Had restless n., and although very sleepy,

continually twisted and turned ; when I did sleep dreamed of being

chased, and when overtaken, about to be scalped ^ could not make a

Jound to call help. Woke at 5 a.m. Frontal headache, which had

disappeared during c., returned with increased violence. This, with a

perfectly exhausted feeling as if I had had no rest for a long time,

Dade it an effort to dress, but afterwards I felt better, although I could

eat but little breakfast, as even odour or sight of food nauseated me.

■ I a.in., severe pain in region of heart, lasting but a moment, and

recurring at irregular intervals of 5 m. — J h,, making me catch my

breath, and turn pale even to lips ; pain cutting in character, worse

"during inspiration, and passing directly through thorax in region of

"Wrt. This recurred 1 1 times ; immediately after each attack very

^irsty, flushed, and exhausted. Pulse irregularly intermittent and 72.

*ftnp. normal. 4 p.m., taken suddenly with cramp-like pains in

*wrists and knees ; wrists especially somewhat sensitive to touch ; cramp

'''d sharp pain soon settled down into steady ache like rheumatism.

•'^•tsame time deep dull boringpain in r. hypochondriac region, which was

Suite severe, and only relief was from constant pressure and motion, as

*ying down or sitting aggravated. This lasted nearly 2 h., and then

K'adually disappeared, while pain in knees and wrists persisted. Temp.

^4°; pulse 82. During e. headache and pain in back of neck re-

^rried. Headache relieved by cool water, and in open air. 9, urgent

^*^1 to stool ; large movement of dark-brown, rather loose and offensive

'^^tter, causing much excoriation and pain. 10, 90 dr. Felt very

^^PXi ^"'^ went to bed immediately, but headache kept me awake for

^'^ h., and on shutting eyes there appeared bright spots, star-shaped,

*ncing up and down, i a.m., startled out of deep sleep by severe

Pai,

apex-

1 'n in region of heart, and then violent action of heart set m ^^^t to be felt and seen over large area, accompanied with suffocating ^feeling and almost inability to breathe. Had to sit up in bed, and turn •"St one way and then another, almost as in a severe case of asth ^fen accompanied by several spasmodic coughing spells. This ^f>eated 3 times during n., and at one time (4 a.m.) I became almost .'^conscious from agitated tumultuous beating of heart. ~ ^**^e 101°; pulse no. 22nd. — Slept hardly at allj j^^hausted, and had almost constant hawking, without

*tnetimcs arising from tickling in larynx, and again from sort of ^ Oppressed feeling in lungs. Headache also continued, frontal, extcnd- **^g into orbits ; eyes bloodshot, with red margins, and feeling as if full

VOL. IV. 28

Temp, at this felt weak and expectoration.

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of sand. Very thirsty^ but no appetite ; craved coffee and lemonade. 9 a.m., temp, one degree below normal ; pulse only 70. I had now taken drug 4 times, and in all 200 dr., and, being somewhat lightened at action on heart, decided to wait a week before continuing proving. Headache lasted 4 d., gradually decreasing ; pain in back of neck lutnl 3 d., although amounting only to stiffness last d. Cough lasted all the week, although, excepting this, I had not the slightest symptom of » cold J cough, however, amounted only to a hack, with now and then — perhaps 3 times a d. — a coughing spell, which I noticed came on only in open air ; slight hoarseness was also noticed at same time. Bowels regular, but rather loose^ and stools caused some burning and pressure for an h. or two after. Otherwise was feeling as usual. On 5th d. menses appeared, anticipating 8 d. Flow increased, bright red, and lasted 5 d. Dysmenorrhoea, with bearing-down feeling and piin in r. ovarian region. Very nervous, easily startled, and hysterical.

h. Nov. 3rd. — Seemingly in perfect health except cough, which had continued, at 10 a.m. took 50 dr. Dyspnoea was marked in i$nn., with sharp cutting pain in lower portion of r. lung. Cough continued and became more frequent, with scraping sore feeling under sternum -, seemed more spasmodic, recurring at almost regular intervals of about 20 m.,and was of a voiceless stifled character. Towards c. same headache began to return, and the peculiar stifF feeling in back of neck, so that involuntarily I put my hand constantly there to try and relieve by pressure. Cough continued, and during each attack I felt sharp pain in lower portion of lung. 10 p.m., So dr. ; went immediately to bed. Slept very heavily till 4 a.m., though dreaming constantly ; was waked at this time by bad coughing spell, lasting several moments. Head aching severely, eyes bloodshot and heavy, with red burning eyelids ; back ached whole length of spine; face flushed, but body cold. At 5 a.m. temp. 98'6°, pulse g2. On attempting to rise was seized with vertigo, felt as if falling forward, everything became black, and I grasped for support ; this was accompanied by nausea, which prevented my eating breakfast, and 20 m. after I vomited coffee and toast which I had succeeded in taking, to a.m., 120 dr. Dyspnoea immediately, marked, with severe coughing spells occurring at intervals of 10m.; aphonia and pain in lower part of r. lung on deep inspiration or coughing. Pain in back became very severe, and was localised more in cervical and upper portion of sacral region. 1 2 m., cough continued, and one attack of pain in region of heart as in previous proving. Vertigo as if falling forward, with black spots dancing before eyes, and in going up and down stairs felt as if I were stepping over too far and should fall. Cough aggravated by exposure to cold ; ameliorated in warm room ; not especially painful except as it caused pain in lungs, which lasted several moments after each coughing-spell. 4 p.m., urgent stool at i p.m. and another at 3, small, watery, dark, and offensive ; no pain accompanying, but severe burning in rectum and anus following. Temp. 100°; pulse 110. Very thirsty, and drank large quantity at a time, to, 200 dr. In 5 m. urgent stool ; same colour and consistence as before, and same burning pain following. Every inspiration an exertion, and very unsatisfactory, as deep breath-

M-M.

g brought on pains in lower part of r. lung and in heart. Cough DOftt constant, unless in very warm room. Head and back ached ; ick stiff; carotids throbbed. Pulse 130 ; temp. 103° at 11 p.m. mstant dyspnoea; respiration 36. Frequent urination, once in 3 h,, ant/ and high coloured ; sp. gr. 1025. 5th. — Very restless n.> with ightful dreams of being killed or burned ; bright images before eyes, bich were sensitive to light, with dilated pupils, and bloodshot. loDstant and increasing sense of constriction across chest, as if I had been running fast and long, or as of heavy weight on chest. 5 a.m., lovement of bowels, followed by same burning and stinging, and slight cmorrhage as from piles. Cough not quite so frequent or painful ; ^pncea continued, with same oppressed feeling in lung. Head and ick ached ; was perfectly exhausted and very weak. No appetite, but try thirsty. Temp, at 7 a.m. ioi'2°; pulse 120. Coccyx seemed loneated, was extremely sensitive to pressure, and ached all the time ; Dula not sit except on foot- or air-cushion, to raise it from chair. )raggjng pain in lower part of pelvis and back. 11 a.m., severe ching pain in r. ovarian region, causing me to forget all other pains, ndwalk the floor. Pain constant, radiating from r. ovarian region to tip, thigh, and back, with occasional shooting darting pain, causing Be to hold my breath, and at same time leucorrhoea, coming with a ^h, of milk-white colour, coming at no other time. This lasted till ) p.m., when it ceased suddenly, and from that time back and head Kgin to feel better. Two movements of bowels at 10 and at 3, kn.— Had more comfortable n. ; cough less frequent ; dyspnoea not so decided, although oppressed feeling still present. Felt weak and cxlamted, but better appetite. Back and head still ache. Temp, and wise normal. Frequent urination— 30 oz. in 24 h. ; sp. gr. 1030 ; Kid reaction. Only 3 movements in a day, but still somewhat loose Ind excoriating. 7th. — Am feeling well again. Head rather weak, md slight cough remains.

The drug seemed to have no long-continued effect ; unless the fact liit in this month the menses again anticipated nearly a week, with Defeased flow, be attributed to this. [Publ. of Mass. Horn. Society^ 1885.)

8, a. Lucy Johnson Pike. The following proving was made "upon myself under the direction of Dr. Southwick. My weight is l/S lbs. ; height 5 ft. 4 in. ; hair light brown ; eyes blue ; normal pulse-rate 80 ; resp. 16. At the time the ist dose was taken I was 25 )^n old. Health has always been good, with exception of an attack *f diphtheria in 1878, which yielded readily to the simillimum, and left no chronic lesion. All functions being normal, took first dose of •0 dr. at 7.45 a.m., June 20th, 1884. Pulse and temp, remained normal, and no symptoms appeared throughout d. 21st. — 10 dr. at 745 a.m., ajid again at 12.45 V'^'i ^'^^ ^° variation in health. Sind, — No drug taken, and no symptoms. 23rd. — 20 dr. at 7.15 a.m., lod again at 12.45 p.m. ; no drug symptoms. 25th. — At 12.45 P-ni., ind again at 3.30 p.m., 25 dr. About 6 p.m. a sudden and violent pain ircr r. eye, accompanied with boring through temples. Pain soon tread over whole head. Heavy pressure on vertex. After this had »ted about an h., vision blurred as if eyes were looking through blue

lace ; nausea and dizziness marked, as well as loud noise resembling a windmill, in 1. ear. About 12.30 p.m. pains abated. 26th, — At

4 a.m., having slept about 3 h., nausea seemed to wake me. No relief on rising, in fact worse, and giddiness prominent. At 8 a.ni. pain seemed to have gone, although nausea still remained, and occasionallj noise in 1. car was marked. 9. 20, slight nose-bleed, ix a.m., 25 dr. Symptoms not aggravated, with exception of noise in I. ear, which lasted about a m. at a time. At 12.45 P-*^- ^5 ^^- Nausea increased. At 3.45 p.m. 25 dr. 4.30 p.m., nausea and giddiness, so bad that I was obliged to go to bed. Violent pain in head returned, still wotx over r. eye. No position comfortable. Faintness spread over whole body. Glass of ice-water and cracker taken with relief. About 10 p.m. pain subsided, and I slept till 11.30 p.m., when a dream of suffocation awoke me. On rising, dizziness not so much felt, but general sickness, head sore to touch ; I did not care if I lived or died, and decided not to take a drop more if I ever felt better. 27th. — At

5 a.m., after sleeping about 4 h., throat felt dry, and voice was hoaree. Occasionally pain in head, but nausea and giddiness less. Tongue had a yellow coating. Glass of ice-water relieved all symptoniJ. 8.20 a.m., nose-bleed, more profuse than before. 12.30 p.m., feeling better, took a little lunch, which brought on nausea again. i.3op.ni., 30 dr., with no aggravation until 4 p.m., when there was sharp and sudden pain in r. ovarian region, which later radiated down thigh tni across I. hip, relieved by lying down and flexing thighs upon abdomen. Head dull and heavy ; 1 could not walk straight or upright, abdominal pain was so intense. Throat seemed to be clutched. Hoarseness gone- Temp, and pulse were up to this time normal, but at g p.m. puUc 64 and temp, gg°. 10.30 p.m., 30 dr. Sleep almost immediately followed. I dreamed that throat grew up, and awoke in fright, finding it very difficult to breathe. I was trembling violently, and I. arm wa* numb and heavy. (The numbness of the arm I have felt before, and the position in which I lay, on the 1. side, may account for it.) Nsusea great ; but it was easy to walk, except that I could not get orer thought that I was suffocating. In about an h. fell asleep, and did not wake till 6 a.m. 28th. — Throat painful to touch and voice 1 little hoarse. Nausea present. Head felt big, and eyes could not bear light. Pulse 68, temp. 9Q"5°. Pain in abdomen gone. Milky white leucorrhoea. Tongue had still a thick yellow coat. Felt better after eating breakfast, but was very tired all m. In afternoon I went to walk. About 4 p.m., while out of doors, an indescribable sensation came over me. I really thought I was dying. Whole body seemed ^ling in pieces. Atmosphere appeared blue, and there were constant flashes of light before eyes. Could not walk straight. Occasional); noise in 1. ear was noticed, but it seemed this time like a loud bell ringing at a distance. My body felt as though it were elastic and stretched itself out. Tongue seemed alternately to expand and contract. Ice-water relieved nausea. L, side numb. On lying down symptoms were better, and at 10 p.m. I fell asleep, awaking in about an h. with a sense of suffocation, which soon passed away. 2Qth. — At 6 a.m. pulse 72, temp, normal. Tongue still coated. Head fdi

+37

rge, and there was pressure on vertex. Occasionally disturbed by

nging in both ears. Nausea had gone, and I felt unusually hungry.

jkeucorrhoea profuse. About 4 p.m. irresistible sleepiness came over

Sf and I slept from then till 7 p.m., awaking simply long enough to

a bountiful supper ; and again slept with slight ititcrruptiun till

I a.ni. 30th. — Pulse 72 ; temp, normal. Throat dry, and it required

It exertion to talk ; all food very acceptable. Leucorrhcea still

)undant. Head sore to touch. July ist. — Pulse 78 ; temp, normal.

foogue still a little coated. No leucorrhaea, but pain in sacral region

}ubled me a little. L. arm a little numb, and, — Pulse and temp.

rmal. About 6 a.m. a little frontal headache with slight nausea.

i. — Tongue almost clean, and no leucorrhoea, though I felt tired all

4th. — felt quite well. No more symptoms arose from proving.

p. gr. of urine varied from 1015 to 1019. Bowels not affected.

lenses appeared 2 d. early. Remained perfectly well from 4th July

7th Aug.

h. Aug. 7th, all functions being normal, took 100 dr. at 12 m. with no effect during rest of d. 8th. — At 6 a.m. sharp cutting pain in r. Parian region, extending about hip and down thigh, awoke me. Could >t find any position comfortable. Head ached violently through iples and on vertex. Top of head felt as if uplifted. Loud ringing r. ear. On lifting head very dizzy and somewhat nauseated, ^yspncea great. Feared I should lose my breath entirely. Had hardly >urage enough to take any more drug, but did at 10 a.m. take 1 00 dr. ^mptoms all increased. Was unable to rise. Very chilly, though ly was quite warm. Abdominal pain grew worse. At 12.30 p.m. lenses appeared 2 d, in advance. Headache increased ; pain in abdomen almost unbearable, though somewhat relieved by heat. Abdominal pain not continuous ; intervals between attacks almost regular — about 10 m., and spasm lasted 5 m. L. side numb, back of neck same ; face flushed ; eyes twitched, and pupils were dilated. Everything looked blue. Very cross and hungry i but food increased nausea, while water relieved it. At 2 p.m. chill, which lasted about 5 m., attended by great nausea and vomiting. At 3 p.m. temp. 99*5°, pulse 96. Abdominal pain so agonizing I could hardly endure it. About 6 p.m. symptoms abated, and I fell asleep, but was restless all n. 6th. — Awoke with dull pain in r. ovarian region and frontal headache, with a little dizziness. Limbs ached. L. side felt numb, especially I. foot. Flow profuse. So unwell I could not take any more drug. 1 0th. — Still very weak and tired. Flow profuse, but ovarian pain slight. Head felt mixed; it seemed entirely void of ideas. It was an exertion to try to think. Throat ached, and dyspnoea came occasionally, nth. — Flow abundant, I felt tired. 12th. — Flow less. 13th. — Flow disappeared, but left white leucorrhcea. 14th. — Felt well. Leucorrhcea less, and no traces of it on J 6th.

c. No symptoms from 16th until 28th, when at g.30 a.m. I took

10 dr ; 29th, at 3 p.m., 25 dr. ; 30th, at 1 1 a.m., 50 dr. ; and 3131, at

1 1 a.m., 50 dr. First symptom occurred this d. about 2 p.m. Temp, normal, pulse 76. Dull frontal headache, loud noise in r. ear as of a valve continually opening and shutting. Somewhat sick at stomach

and dizzy. At 5 p.m. sharp, cramp-like pain in 1. inguinal re^tio, which increased until 7 p.m., when menses appeared 5 d. early. Few about an h. pain seemed better, but after that began with renewed violence, worse than in two former provings. Thought I could not get enough air into lungs, inspiration was so difficult. About lop.ai. fell asleep, as pain had abated. Sleep was restless, being interrupted br several attacks of dyspncea. Sept. 1st. — On rising was very dizzy, sick and chilly. Throat felt as if in a vice. L. side numb. It seemed in walking as if floor were soft like wool. Arms felt better from being twisted. Pain, rather of a dull character, extended from nape of neck to r. shoulder-blade. Pain in 1. ovarian region intense, not a constant pain ; it began feebly and gradually increased, dying in same manner. All d. I felt something bad might happen. About n. headache and abdominal pain subsided, and I felt well. 2nd. — On awaking, whale body numb, especially I. side. Felt great desire to inspire, but was unable to get sufficient air. On rising very dizzy. Tongue hid heavy white coat. Joints seemed loosened. Everything looked blue, and there was loud ringing in r. ear. At 8.30 a.m. took 60 dr. 84S, had slight chill, accompanied by death-like nausea ; soon followed ij vomiting of thin white mucus, after which felt better, though very tired. Arms felt as if they had carried heavy weight, legs very weik. It was an exertion to talk. Flow very abundant, abdominal piin slight. 3rd. — At 7 a.m. took 150 dr. At 8 a.m. ate good breakfait In about ^ h. great nausea, and I soon vomited all the breakfast. At intervals all d. dyspnoea great, muscles of back seemed tired, and I ached all over. Limbs heavy, and occasionally I. side numb. Pain ia head better, roaring in both ears troublesome. Throat ached. It w« tiresome to talk, and voice sounded hoarse. Flow profuse, 4th.— In m. felt better, and took at 10 a.m. 100 dr., but vomited it all in a few moments. No headache. No abdominal pain, though flow u abundant as d. before, and I felt very tired all d. fch. — With exception of occasional attacks of suffocation, and great weakness of lower limbs, felt well. Flow about the same. 6th. — Very tired. Flow less, and continued to decrease till loth, when it ceased. 13th. — White thinleucorrhcea, which lasted 2 d. Only slight variation from normal was anticipation of menses, once on 26th Sept., the other 2lnd Oct., which seemed more abundant than usual, though no pain.

d. Fourth and last trial of drug was made on 3rd Nov., at 8 p.m., when I took loO dr. Shortly after stood about \ h. on sidewalk to watch procession, and ground seemed damp ; this may have modific( proving somewhat. 4th. — At 10 a.m. unable to inspire freely ; dull headache in frontal region : slight nausea. In walking, very dizsj. L. arm numb. Throat ached. Loud ringing in 1. ear. Ac 2 p.m. took 60 dr. About 4 p.m. dull pain in back of neck. Lower limbi ached, particularly at articulation of knee-joints. Dyspnoea marked. During e. pain in neck increased ; whole head ached, particular! through temples. Head felt dropping in pieces. If I sat up, felt isi floating through air ; if I lay down, as if sunken deep in bed. Object near seemed a long way off. 5th. — On rising dizzy, and head ache< violently through temples and on vertex. Noise in both ears ao(

numbness through all limbs. Nausea slight. Dyspnoea noticed several times. At 7 p.m. took 75 dr. Symptoms all increased, in addition there was dull pain in 1. ovarian region, and back of neck was rather stiff. Awoke several times during n., and always with sense of sufFocation. 6th. — ^At 8 a.m. took 145 dr. Headache intensified, dyspnoea great, and neck stiff all m. About noon abdominal pain increased. At 3 p.m. chili and great nausea; chills lasted about 10 m. Neck very painful ; pain extended intor. shoulder and down back. Difficult to turn neck to 1. At 2.30 p.m. another slight chill, with nausea. Headache and abdominal pain increased ; latter greatly relieved by lieat. Flashes of blue light before eyes. Everything looked far removed. At 6 p.m. aconite was given, and repeated every 15 m. till 5 p.m., with no relief. At 10 p.m. took i teaspoonful of tinct. camph. mixed in proportion of 5 dr. to 10 tablespoonfuls of water, and in about ad b. fell asleep. 7th. — Pain in head somewhat better. Neck easily turned. Abdominal pain about same till noon, when it began to grow better. Camph. every h. throughout d. Suffocation at short intervals. Pupils dilated. Throat felt as if clutched. Milky-white leucorrhoea. 8th.— Very tired. No pain. Limbs occasionally numb, and I was dizzy in vndking. Some suffocation, with feeling of heavy weight on chest. Leucorrhoea was not much. 9th. — Felt pretty well. lOth.— Well. No symptoms.

Throughout last proving urine seemed increased in quantity. Bowels not affected at any time. Menses up to Jan., 1885, anticipated

S( or 4 d. In Dec, 2nd d. previous to menstruation, milky-white eucorrhoea, not profuse. Otherwise usual health. Appetite excellent all the time. {Hid.)