Mezereum

Volume III — Main text

MEZEREUM.

Daphne Mttereum., L. Common merercon, spurge olive. Nat. Ord., Tkymtliutet.

1. Prmings. — 1. Hahnemann, Fragmenta de Virihus. Contains 62 symptoms from self, and 34 from authors.

2. Ibid, Chronic Diseases j part iv of original, vol. of translation. Contains 610 symptoms, including contributions from 11 other persons.

3. a. Dr. Hartlaub, aet. 41, phlegmatic melancholic temperament, in good health, March 30th, 1849,5 p.m., smelt at the fresh bark and chewed a piece. Taste acrid and disgusting, then smarting burning like pepper on tongue, repeated eructation of air, shuddering loathing, earache (doubtful), l^he burning spread from tongue all through buccal cavity, especially hard palate, with great dryness of that part, especially posteriorly, and in upper part of cesophagus ; much saliva and hawking of mucus, which detached itself easily. Mucus came down from choana and was apt to get into air-passages, causing hawking and lachrymation. Rough embarrassed speech. After i h. the smarting has spread to the lips, which are dry and swollen \ this lasted till e. ; taste diminished, tongue felt scalded. Pressive pain in upper part of forehead. K., twisting pain about navel, with nausea and as if waterbrash would come on or faint feeling, tearing pain across chest anteriorly.— 31st. Perspired profusely ai n. and woke frequently, strong erections with sexual desire. In m. soft, brown, sour-smelling stool, scanty urine, tongue and palate feels scalded. A.m.,cory2a in eyes and nose, with increased thirst, hot skin, and quick pulse, swelling and heat of penis. All d. repeated discharge of flatus, with several soft stools. E., again chewed some bark and flowers, and was exposed for 1 h. to exhalations from bark while preparing it for medicinal use. This caused violent smarting and burning in mouth, with much watery saliva.

Another soft, dark, greyish, or black stool, with much borborygmus during and after stool. — April ist. Long sleep, perspired a little. M., scanty urine, with increased thirst; tongue as if scalded. 9 a.m., a soft, dark and light brown stool as if fermented, with much indigestible matter and very fetid. A.m., frequent discharge of much watery urine, warm hands and cold feet and legs up to knees, hard pulse. The same kind of stools continued for several d., always in forenoon and partly light coloured, loss of appetite and discharge of fetid flatus, pcrvpiration in m.

h. March 4th, 1850, 4 p.m., chewed several pieces of fresh bark, and was exposed to exhalations for 5 h. while preparing the medicine, till 9 p.m. Next m. pressed out the macerated bark. When chewing the bark had but little burning or smarting in mouth, later the peculiar pain set in severely, and next m. the epithelium became detached, with swelling. After some m. burning in mouth, not on the part touched by the bark but in fauces, relieved by breathing in air, but increased ; felt very weak and faint. After ^ h, mucus from nose and smarting and watering of eyes. After } h. eructations, transient pain in fauces anteriorly, pain in middle of r. eyebrow. 7''he smarting spread gradually from fauces through whole mouth to lips. 7 p.m., fouces painful on swallowing, and as if swollen and excoriated or scraping. 7.30 p.m., prickling in oesophagus when swallowing. 8 p.m., the pain in oesophagus violent and general, very painful when swallowing, especially in uvula and soft palate, pricking pain and as if swollen in 1. meatus auditorius, at same time rheumatic headache on 1. side, a kind of tearing. iO p.m., same pain in upper part of head and in I. ear. E., loss of appetite and chilly, then general heat and perspiration. Transient pressive pain in eyeballs. — 5th. Yesterday on going to bed violent itchins in legs, so that he must scratch. At n. vivid but not remembered dreams. Some sweat towards m. On rising scanty and slow discharge of urine, of strong smell, dark and hot. Forenoon till noon, repeated hurried discharge of urine, the water he washed in felt unusually cold, the air too felt very cold, especially to his head, and he felt when sitting in room as if cold air blew on his head. On pressing out juice, smarting in eyes. 8 a.m., stretching of body and yawning, eructations, discharge of fetid flatus, drawing-tearing pain under r. knee externally and in metacarpal bones behind 1. thumb, also in distal phalanx of r. 4th finger and r. wrist, where the metacarpal bone of index joins it. Pulse accelerated a.m. To-day the mouth symptoms increased, those of fauces diminished. All d. mouth very painful, the epithelium of inner surface of lips and of gums of front teeth quite detached where the bark had come in contact with it. Much toothache, the gums bleed easily, tongue much swollen, especially at its tip, with thick white coating and prominent red papillx on a white ground, tip of tongue very red, epithelium denuded, a deep fissure in middle of tongue, external lips dry, taste almost extinguished, milk tastes smoky, teeth very painful when biting and when air meets them, with constant drawing pain in them all d., the upper front teeth of 1. side particularly affected. P.m., painful jerking in lower 1. molars, cheeks very painful when' pressed, and as if swollen. £., toothache increased, especixlly in L

upper incisors. Also painful pressure in eyeballs, diminished appetite, pain as of dislocation in r. big toe. £., copious, soft stool, as it fermented and not quite digested, of brownish-yellow colour, very fetid and sour smelting. — 6ih. Woke last n. at 2 a.m., fell asleep again, and towards

5 a.m. a scanty, thin emission, many unrcmembercd dreams. On rising in m. tinnitus in r. ear, can hardly move r. leg, knee feels weak.

6 a.m., feeling of hunger in stomach, with borborygmus ; noon and e., diminished appetite, stomach feels uncomfortable after eatin^r, especially &t things. Mouth better to-day and toothache gone, some hollow teeth in mouth have become sharp, tartar on teeth rough. Tongue still swollen and large ulcerated papilla, not coated but very red. External lips all d. very dry and shining, very painful in e., some burning, especially near them inside. During d. hurried micturition. After ■upper much eructation of sour rancid taste; very tiresome pressure in stomach, with very irritable temper. Distaste for everything, he would like to run away, very drowsy after supper,apt to start with palpitation thereafter, frequent yawning, stretching of limbs, itching in several parts of body, especially scrotum and nostrils. E.» shuddering frequently all over body, also over several parts, over I. leg downwards ; pulse 80 to 90, rather full. Stool in e. insufHcient and hard, much itching in and about houghs, scratches himself raw. — 7th, m,, after rising rheumatic pain in muscles of 1. scapula, tongue and mouth inHamed and red, uncomfortable pressure in stomach and abdomen, jerking stitch in r. side of chest about lowest ribs, then beneath r. scapula. Several times durin? d. and in c. much itching about anus. — 8th, m., on rising very tired, this goes off during d. 7 a.m., stool (after 33 h.) copious, soft, fetid ; on urinating the last portion causes smarting-burning in fore part of urethra i soon afterwards violent itching in 1. inner canthus, appetite diminished, stomach easily deranged by fat food. — 9th. Painful swelling in r. concha above meatus, humming and buzzing in r. ear. Noon, on rising from stooping many black spots before eyes. Hollow teeth very sharp. No stool to-day.

c. March 14. While preparing the med. was exposed to its emanations from e. till 3 a.m., also chewed bark. Immedi.itcly after chewing, nausea, loathing, burning in fore part of mouth, tongue, and further in mouth, with Bow of saliva ; tearing drawing through r. big toe ; smart* ing in eyes ; loud rumbling in bowels, flatus rushed noisily through anus. — 1 5th. Scanty soft stool m. E., again exposed to emanations. — 1 6th, m., noticed a large sugillation on back of r. hand behind index, not caused by external violence ; it is a discoloured swollen not round spot about 1" in diameter, quite painless. At same time violent itching on this hand, especially on wrist, and intolerable transient itching on several parts of body ; some liver spots more scurfy than usual. Sensitiveness to cold water, also of the leeih when drinking j tongue coated white, yawning; no stool to-d., and very little urine passed. E., exposed for 2 h. to emanations of plant. Soon, intoxication and constriction across chest anteriorly not deeply seated, and at same time over back about scapul;£, drawing pains in rectum and anus, occasional pain in glans penis j after urinating cutting pain in front part of urethra ; irresistible drowsiness; indifference to everything. — 17th. Immediately

after rising, m., inflamed eyes, conjunctivz much injected, dirty red, especially about external canthus of 1. eye, with pressive pain as from dryness -, several times urging to urinate ; pain in r. ear deep in meatus, a stitch still deeper, meatus of that ear more open than the other, feels swollen or relaxed ; difficulty of thinking with pressive confusion of head, and here and there pressive pain in head, hair hangs down loosely. A small cut is very painful for a long time. The sugillation on r. hand is paler and painless. In forenoon, smelt 16 different preparations of mczereum for \ h. and again in e. In forenoon, dark, lumpy stool expelled with much pressing. After dinner, irresistible drowsiness with painful pressure in eyes, the conjunctiva of lids very inflamed. Occasional itching in anus. Afternoon, a shoot up anua. £., when sitting still, violent, painful, paralytic pressure in r. acromion, on depressing arm the pain much increased from the weight of the arm ; soon afterwards, when walking, as if dislocated in r. hip-joint and outer aspect of thigh about trochanter maj. 9 p.m., an h. after supper, shudder down body, with yawning. E., very sleepy. — i8th. Dreamt much at n. On rising, m., incisor teeth very sensitive, especially on biting ; whole head confused and heavy, chilly, general malaise ; some streaks of blood in expectoration. Forenoon, tasted these 16 preparations for i h. After ^ to I h., eructation, smarting on lips and tongue, violent burning as from pepper on front of tongue and lips; rheumatic pains in muscles of scapulx, like tension and swelling. After dinner, borborygmus in bowels and loud discharge of inodorous flatus ; dull pain in 1. side of chest behind heart, probably in lungs. Very cold hands. 3 p.m., when sitting writing, involuntary twitching of whole r. lower limb on its inner side, a jerking and twisting. 5 p.m., burning on lips and tongue as if excoriated, but not really so. Some discharge from nose ; thirst for cold water. When near the fire, pressive frontal headache, £., increased general heat, quick pulse. 7 p.m., feeling of air in and distension of r. meatus externus. 8.45 p.m., gums behind upper incisors swell up in a blister and also on hard palate anteriorly, upper incisors on edge. Drowsiness, shuts eyes involuntarily, and legs jerk involuntarily. Fell asleep before lO p.m. and awoke in a stupefied condition about T I p.m. ; on attempting to walk, violent pain in r. meta,tarsal bones ; pulse still quick. No stool today. — 19th. Difliculty of getting to sleep, e., woke several times with pains in bones, especially of 1. wrist and knees. M., urging to urinate, got up at 4.30, having had but little sleep. After getting up, m., rheumatic pain in r. knee i soon afterwards shooting behind third and fourth toes, also in 1. metatarsus. The eyes, especially in 1. canthi, stick together, with itching and pressure j some coryza and lachrymation, the upper incisors on edge, audible borborygmus in bowels with feeling of hunger, hiccough Forenoon, quick pulse, chilliness, cold feet and hands ; skin of hands dead and chapped and corrugated. 10.30 a.m., sneezing several times, increased thirst for co'd water. The epithelium of front part of lips, of gums, and of tongue is quite detached to-day. There is no burning or smarting, the denuded parts are destitute of feeling and taste, the tongue feels scalded, is white coated, and the tip excoriated. In the chin beard is a small pustule, and a couple of pimples on chest. After-.

I I

noon, hard, lumpy stool, with much pressing. 5.30 p.m., burning in r. acromion ; when walking, pain of 1. big toe as if dislocated, cold feet. Smelt the tincture while stirring it. — 20th. Felt cold during n. and in m. on waking, woke frequently with violent itching in lower limbs, nocturnal urination. The decayed teeth get sharp and decay away, the tongue is swollen and red, with white coat ; sneezing, pulse slow, no stool. Smelt the tincture while stirring it. — 21st. Long of falling asleep last n. Slept later in m., some blood in expectoration. Forenoon, copious stool. Epithelium restored in mouth, anorexia, teeth much decayed away, and sharp, fluent coryza. Again exposed to emanations of the drug. — 22nd, m., blood in expectoration, chest feels weak. The pimple on the chin has become a small ulcer, with thin, oily, sticky discharge, and is very painful ; the outer wall of r. ala nasi inflamed, swollen, and painful ; fluent coryza, alternating with stuffed nose, r. nostril completely stopped with scab and very painful, the ordinary liver spots on chest and arms very dark and scaly, great itching on back of both wrists where several small, dry, dark brown scabs have come ; tongue swollen and its tip feels scalded. On rising, m., teeth sensitive when pressed together, especially upper incisors, very bad appetite, stool copious, brown, firm, and lumpy. — 23rd. Again exposed to emanations. Nose as yesterday ; drawing pain in r. sole when treading. Occasional slight shooting and drawing pain in anus and fore part of penis. Nose and ulcer better during d. — 24th, Woke at n. with vivid dreams of someone walking about in house and speaking loudly. Noon, on shutting eyes violent prcssive pain in r. eyeball. Nose and ulcer better, teeth decayed away down to gums. Appetite bad, after eating fulness and pressure in stomach, eructation, with taste of food and acid. No scool.

d. Exposed to emanations from 9 preparations, p.m. Soon, feeling as if wind were howling in r. ear. 8 p.m., some blood dropped from r, nostril j otherwise stuffed nose and scabbincss of r. nostril j great itching in 1. border of lower lip ; r. meatus auditorious feels wide open, increased by yawning, relieved by inserting finger; itching of backs of both hands; on yawning ringing in r. car ; much pressure in eyes, with dry feeling in them. He teels too warm and yet has cold chills, especially over back and lower limbs ; itching in 1. side of anus, in legs, and scrotum ; very drowsy with frequent yawning, can hardly keep his painful eyes open i when walking, patella as if dislocated, cracking in r. knee when walking after sitting i during drowsiness violent erections; pressivc pain in I. side of chest anteriorly, about fourth rib; boring pressivepain on r. shoulder, then behind 1. acromion. 10 p.m., epistaxis from r. nostril. Under I. ear on border of ramus of lower jaw a small swollen gland, painful when pressed. — 25th. Kept awake with many thoughts, always chilly, towards m. warm, very confused dreams. On waking m. dryness of mouth and tongue. Upper incisors very sensitive when teeth pressed together. Very chilly, lazy, and disinclined for work. Feels as if food remained undigested in stomach, out of spirits and indifferent.

r. hand cold, I. war pai

9 45

a.m., as if air were in ears, with pinchin

g

pain, worst in r. ear; on movmg arm feels as if dislocated at Junction of clavicle with scapula. 11 a.m., increased thirst, though he is cold.

No stoo! to-day. — 26ih. Forenoon, when walking in open air, drawing and cutting pain in front part of urethra and neck of bladder, z p.m.^ exposed to emanations. Immediately as if r. external meatus were distended with air, later the same in 1. meatus with feeling at if ear were stopped ; very cold hands, tensive stretching pain in upper part of r. scapula. lO p.m., boring prtrssive pain in r. side of vertex, then in 1. side of forehead, later on r. side of, and above, r. eye, like a peg driven into it ; a stool, the first for 3 d., dark brown and lumpy, with much pressing; afterwards itching on prepuce internally. — 17th, 9 p.m., a stool similar to that of yesterday, before and after it crawling in anus as from thread-worms ; itching on prepuce after urinating. The decayed teeth break off still more — 29th. Yellowish-brown stool, not very firm, with some streaks of blood. Yesterday and today, pressure in stomach after eating baked fruit. During proving brown rings round eyes, with sallow complexion and circumscribed red spots on cheeks, flesh of body seems very lax and falling away, belly very much fallen in. The eruption on the hands lasted liU April I4lh. {Horn, yierteljahrsch.^ viii, 6.)

1. R. W — , housemaid, xc. 26, was engaged in pounding bark. Next d. complained of toothache in some decayed 1. upper molars, jerking pains with pale swelling uf gums, and bleeding and suppuration of them 1, the cheek externally was painful when touched. On another occasion she again pounded the bark, and had violent shooting pain in r. side about lower ribs, especially when breathing deeply. (Ibid.^ 29.)

2. A woman exposed to the emanations had flow of saliva and contractive spasms in heart. (Ibid.)

3. a. Dr. Rrunu Linck, xt. 41, robust, choleric melancholic temperament^ took. May 14th, 1852, Mcz. i,. In \ h., scraping in fauces with flow of saliva j frequent eructation with burning in throat relieved momentarily by drinking cold water; transient pain in car ; the burning and scraping in throat lasts 2 h. Violent, almost painful hiccup lasting almost 1 m. Transient tearing pain in tip of I. scapula and in ). side of back. Slight toothache in carious tooth, transient ; painful fine tearing from one temple to the other, frequently recurring. Fine drawing in I. upper iceth ; drawing pain in r, occiput. — 18th, 5 a.m., same dose. The scraping in fauces soon came on, and lasted till 8 a.m. After 2 h. obtuse pain in region of spleen and in 1. side of chest, long continued, aggravated by inspiration, sometimes most posteriorly in region of 4th false rib. Drawing pain in teeth on 1. side, transient. Greater calmness of mind and body than before. Easy stool (had habitually a painful feeling in rectum with diflicult evacuation). Itching in r. eye and I. whisker. Dull drawing above r. car as if in bones. Afternoon, another similar dose. While walking in warm weather, a long-continued feeling of dilatation in r. ear, and coldness as if meatus were shortened, and membrana tympani were exposed to air. Then itching in r. outer canthus and seading up of it with mucus, compelling him to wipe it often. Drawing-pressive pain above and behind r. car. Burning stitches on skin of arm and leg. The pain in r. side of head continues with feeling as if the part were suppurating, and as if the bone wouJd be painful to touch, which it is not ; aggravated by walking.

Burning pricking on various parts of skin like insect-bites. Pinching in r, car. On going out at n. to sec a patient the pain in side of head returned, and was increased at every step. Fine pricking in upper lip at r, angle of mouth. — igth, m., same dose. Tearing pains in r, clavicle and adjoining parts of neck, transient drawing in lower teeth. Frontal headache p.m. Drawing in dental border of I. upper jaw. Great cheerfulness and desire for work. £., dislocaiive pain in 1. knee on its inner side, ir p.m., dull pressive pains above r. ear, superficially as if in bone or skin, extending to upper border of auricle, gradually becoming more severe and then declining, undulating. — 20th. Same dose. On getting into his cold bath a sudden sharp pain between articular surfaces of I. knee-joint almost making him fall. Feeling of a spider's web or blowing of cold air on I. side of face in the beard. Nausea in throat. Pain under angle of I. scapula. Shooting in I. ear. Great weariness and weakness of knees. Pain in elbow as from a blow. Intoxicated feeling in head with uncommon weariness of knees and soreness of them. Spirits lively.

1. May 27th, e., took a teaspoonful of a mixture of 2 dr. tinct. with 2 oz. water. Slept till 6 a.m. quietly, — 28th. Another teaspoonful. Felt very tired and ill. Pain in r. knee anterioily and externally, near patella, as from a blow. Extreme weariness in knees, especially when sitting, not when standing or walking. Confusion in forehead. Oppression of chest as from heart, with long deep respirations. Nausea in throat, intoxicated feeling in head, trembling as if he had taken too much wine. Drawing-tearing pain in r. wrist. Stretching of limbs, quivering in 1. upper eyelid, great weakness of wrists. Eructation and belching up of fluid, which does not come as far as mouth. 11 a.m., another teaspoonful. Very sleepy e. after 3 glasses of hock. — 28th, 6 a.m., I teaspoonful. Sharp pain on a small spot of thoracic parietes over heart. Extreme weariness of knees and drowsiness ; after a short sleep the weariness goes off. Pain on r. patella as from a blow. "When lying noise like a distant mill-wheel in I. ear, going oft' on rising up. Oppression and anxiety on chest, especially about heart, with deep breathing. — June ist, I teaspoonful. Drawing pain in 1. scapula, drawing-tearing pain about 1. wrist and forearm. Bruised pain above knees, especially when going uphill. Sharp cuts as with a knife on anterior aspect of r. thumb in flesh of last phalanx, frequently. Violent jerking shoots on back of r. hand between metacarpal bones of r, fingers. E., 2 teaspoonfuls. Slept soundly. — 2nd. 2 dr. of tinct. in water at once. Scraping in throat. Confusion in head like intoxication, but not interfering with work. Uncommon laziness of speech, every word is an effort. IndilTcrence, but not out of spirits. £., 4 dr. tinct. Burning as from pepper for a long time in mouth. Drawing-tearing pain in lower jaw and teeth. — 3rd. Tearing pain in I. shoulder. Indifferent and laconic. Noon, 4. dr. Tearing in r. shoulder and forehead. E., disagreeable warm stinking vapour in nose. — 4th. Apparently from a chill at n. colic with pappy, lumpy, brown, very fetid stools, then thin farces by drops, with great forcing in rectum. Indifferent and laconic. Sore pains between toes when washing feet in cold water ; the epidermis is white and puckered up like a discharged blistef.

— 5th. Diarrhcea continues. — 6th. Rheumatism in 1. Scapula and neck, increased by turning to opposite side. — 7th. 5 dr., scraping, burning, pepper-like feeling in palate and fauces. Afternoon, great straining at stool, with scanty evacuation of soft fxces with much pressing, afterwards troublesome painful soreness in rectum. Constant visible twitching at root of nose, tearing pain in knee. Tearing in 1. wrist. (Ibid.^ 29.)

1. a. H. L. L — , woman, act. 32, nervous, subject to attacks of weakness and facial neuralgia, otherwise healthy, proved solution of Mez. I. — May 17th, 6 p.m., a teaspoonful. Soon, painless quivering in outer canthus of 1. eye, lasting some h. Transient shootings in side, shoulder, arm, and fingers. Scraping in throat, causing cough, relieving by hawking, returning more severely after eating, lasting till 9 p.m. Wakes suddenly at n. with violent facial pains like the old neuralgia, but soon going off. — i8th, m., after a walk constant tearing in 1. side of face and teeth. 8 a.m., i teaspoonful. Immediately quivering in canthus. The tearing in face increases to acute pain in jerks. Scraping in throat. Sudden headache with inclination to shut eyes, discomfort in stomach and slight vertigo. Trembling of r. hand, powcrlessness of finger-tips, so that she could hold nothing firmly. Shootings or fine tearing in 1. temple. Great weariness. Slight stitches in chest on respiration. Chest oppressed and constricted. Shooting in ears, especially 1., in repeated short attacks. Tendency to wink. Constant trembling of r. hand. General relaxation, great drowsiness. Occasional rigors. 11 a.m., tearing in face, i p.m., after slight vexation very violent headache, head painful to touch. Stitches in chest increased. Disagreeable chilliness in I. hough, foot cold and often goes to sleep, hand trembles. Great weariness, irritability and malaise, disposition to weep, sadness, disinclination to work. Afternoon and e., pain in r. side. £., i teaspoonful. Great weariness, cannot sleep for i h. Woke about midnight with violent pain on both sides of face, considerable pain in r. side of head. Transient pain under ]. shoulder. Powcrlessness of r. hand. Sleep very restless and disturbed by violent faceache. Pains in lower limbs, cold feeling and going to sleep of them. — 19th, 10 a.m., X teaspoonful. Immediately tearing in face and trembling of r. hand lasting 2 h. Constant rigors, great weariness and drowsiness, prickling in lip as if vesicles were about to appear. 5 p.m., I teaspoonful. 6 p.m., when walking ears felt stretched open and the air penetrated coldly into them. After eating scraping in throat. Slight facial pain at n. — 20th, m., I teaspoonful. Great weariness, must go to sleep for another h. Great trembling of r. hand, frequent going to sleep of legs and feet, constant rigors. Hand so weak she cannot do anything with it, writing is most difficult. 2 p.m., so drowsy she must lie down, and slept 4 h., but was often half wakened by faceache. On waking hands are quite numb, r. foot very painful, shooting pains in it, especially in toes, r. hand trembled violently, teeth felt too long and icy cold. Pale face, and looks ill. Frequent stitches all over Dody. Chilly, cannot get warm all d. Teeth painful when tongue touches them. 9 p.m., attack of extreme anxiety since 6 p.m., weeping, palpitation and coldness of whole body, so weary and weak in all limbs she

can hardly walk across room. N. very bad, faceache and weakness and weariness kept her awake till 2 a.m., and had still faceache when she slept. — 2 1st. Constant going to sleep of hands and feet. At n. much faceache and restless sleep. — 22nd, m., repeated dose. All d. lively and strong, but much troubled by stitches under I. mamma darting through chest to between shoulders, caused or aggravated by breathing. At n. again faceache. — 23rd. Pains in chest all d.

h. May 28th, forenoon, 10 dr. Mez. 7. Soon, disagreeable feeling of nausea in throat as though she would vomit, relieved by eating. Afternoon, slight attacks of faceache, increased in c., went off about midnight. Slept well. — 29th., 8 a.m., 15 dr. Nausea, frontal headache, trembling of I. hand, quivering of 1. upper lid, crawling and pricking in many parts of body. Spirits depressed; laziness; traces of faceache; very tired and ill ; feet go to sleep. Constant stitches under L breast. Disagreeable pain in r. hough as if bruised and lamed ; pain in knee at every movement, but worst when sitting. Scraping in throat. Canchi feel gummed up, making her rub them. Oppression of chest; inclination to breathe deeply; feeling as if chest were constricted ; heaviness of head, must support it. Inclination to close eyes ; stares steadily at one spot. In a brown study, a dreamy state. L. arm feels tense. Drawing in all joints as if they were dislocated. After dinner uncommonly gay, inclined to sing and dance, joke, and laugh as if intoxicated. Trembling of hands^ which are powerless. Desire for wine and coffee. {Ibid., 35.)

1. A man, set. 20, suffering from caries of bones of foot, nearly cured, otherwise well, took 1st d., lodr.Mcz, i, Noeffect, — 2nd d., I 5 dr. No effect. — 3rd d., 20 dr., and so on, every d. 5 dr. more, till he took 40 dr. Then all of a sudden he complained of drawing and tearing in the long bones of all the extremities, with chilliness and rigors, was very sensitive to air. An itchmg eruption like flea-bites came out all over body, which went off after 3 d., but lasted longer on head, and then assumed a scurfy appearance. He complained of the teeth being on edge and feeling too long, especially on 1. side, with boring and shooting in them, though he had never before had toothache and his teeth were all sound. These symptoms lasted a week. {Ibid., 42.)

2. Herinc. [Dr. C Hcring contributes the following symptoms from him&clf, Hartmann, and an unnamed provcr. No information given about the provcrs and the duscs taken or the lime of the occurrence of the symptoms.] Very discontented with himself and his work for several weeks, followed by mental comfort and content. Great irriubility and sensitiveness. Disposed to scold others for trifles; everything annoys him, and he is inclined to say insulting and annoying thing?i to everybody. He stares in front of him without thought. Headache after moving and much speakings especially in temples and both side of crown. The long hairs annoy him, they »eeni to be rougher ; after some weeks the hair seems looser and to grow stronger. Quivering in scalp on r. side of crown^ cea<ing for a short time when touched. Small painless pustules size of millet seeds on forehead at edge of hair. The scales on head

• Thi» ts a revised and supplemented list of the ^-mptoms commuDicated lo the pathogenesis in the Chronic Otstajts by " H. and W., two medical students in Lciptig." — Eds.

are more plentiful, Kbtter, drier than formerly. Small red pimples on forrhead, which sometimes itch. Itching of eyebrows. Con-stant itching behind car*; aftet scratching small lumps rise, which arc scratched raw and arc painful, — for irvrral weeks. Swollen, dry, chapped, desquamating and painful under lip. Di^gu^ting tatite, like what sometimciy come from canotts teeth, in faucrs, and a similar ^melt at back of nose. Burning pressure tn stomach, spreading acrus» at times, wurM when pressed on. Burning in stomach. Large pappy, greasy stooU, after violent rapid urging, followed by smaning in anus. Dark wme-ycllow coloured urine, beconung turbid after i d. The urine after a time has floating flakes and red uind in it. On stooping and when sitting chest is very tight, he muii undo his clothes, bnrathing slower and shorter. Above I. knee a movable half*hard swelling. When walking tends to go with upper abdomen hanging over in front, to walk quick and f>in£r, but all that is done with difficulty and forced. Many very vivid remembered drranis towards m. {Ihitt, +3.)

1. Hartmann. Stupefying pressire pain through r. half of brain from occiput to forehead. (JhiJ.).

2. VV. (No name of prover given.) Nose seem^ to him to be bigger and shining. Smarting like mustard in nose. Small plugs easily picked out of nose and check, others form. Great itching on border of lower jaw (after 5th and following d.). Scraping and burning feeling in upper part of faucc*, soon after taking med., going otf attcr drinking milk and eating bacon. Easy hawking up of granular transparent mucus. After speaking feels throat atfccted. Great desire for fat bacon. Eructa* tion of air, with burning and sweat of anxiety. Feeling in stomach and lower part of resophagus as if after fasting too long, but without longing for food; after eating this feeling goes off, biil returns after a few h. The burning in fauc<«t oesophagus, and stomach relieved by swallowing food, as also the anxiety and diarrhcEic feeling. Great derangement of stomach, much trnMve and spasmodic pain, especially before food, for several weeks. Many short, very fetid otscharges of flatus, rspecially before stool. Constipation after S d. The stool is vcrr quickly passed, and is followed by great relief. A feeling of diarrhcea rxtciKU from recrum, then a rigor passes over body, and the feeling goes off. Single violent sneezes, during which granular mucus Bows out oi throat. On inspiring a whccxiog in nose. Nasal mucus increaMd and thicker, with great noise on blowing nose. Breathing full, not free, and less easy than usual. Larynx ieels narrower, he hcan and fccU the air going through larynx when he t.ikc» a deep breath. On taking a mmiihful of water and leaning for^vardi;, he suddenly lost hi» breach, so that he muse quickly spit out the water. On breathing deeply small stiich below heart. Burning around both outer ankles In circum<tcribed spots after working long with hands tn cold water, lasting half the d. Pain in frontal bone extending down to fool. Thr toes arc painftji. as ftxim hard, tight hoots. Cutaneous ulcers came on the prominence^ of tlie bones. Sometimes longing for, sometimes horror of, the open air. He is bent when walking in open air. Veins of hands are blue, skin soft and smooth, p.m. and <. In e. the room feels too hot, and his face perspires. (JtU.}

3. a. Dr. Watzke, June 2nd, l86j, i p.m., took 4 dr. tinct. on sugar. Immediaiely, violent burning on posterior surface of palate and uvula, lasting till after dinner (3 p.m.). At same time flow of saliva, sickness, and contraction in stomach. After eating, the palate and uvula felt as if they had been scalded with hot soup. This lasted all afternoon and recurred the following m. All next d. there was in those parts a feeling of roughness, scraping, and dryness, which continued during the following days, always worst in m. Dull, shooting pains in cardiac region, apparently seated in intercostal muscles, with sharp stitches when coughing or sneezing, came on on the 4th in the m., and lasted more or less for 12 to 14 d. They were worst c. and m.

i>' June 2ist, I p.m., 5 dr. tinct, in water. The burning pain was again very severe and lasted till 3 p.m., till after dinner. The

discomfort, the inclination to vomit, the feeling of contraction or rather constriction of stomach and throat, were much worse and more tiresome than in the Hrst trial. Next d. there could be heard and felt a distinct rubbing sound in the cardiac region where the p^n was felt on the first trial. During d. on movement this was scarcely perceived, it came on almost exclusively after lying down in e., and then when lying on 1. side and when breathing deeply. Chest felt too narrow, as if he could not take a full breath, and it lasted nearly alt next d. This rubbing sound lasted till the middle of July ; a not very easily dcscribablc sensation of weight and obstruction in cardiac region, and a feeling on breathing deeply as if chest were too narrow, was felt for 8 to 10 d. longer. (jf, A. Z., Ixxiv, 46.)

1. Dr. Etterlin, set. 50. — Aug. 15th, 1864, 8.30 a.m., 3 dr. tinct. on sugar. Immediately, burning and scraping in throat, on tongue, and palate, later feeling of malaise not easily dcscribable. On coming into a warm room there occurred nausea, which went off on going into open air, but the pain in throat lasted some time longer. — 1 6th) 8.3c a.m., toolc 4 dr. in a teaspoonful of water. I'he same burning in throat, but not so severe. The malaise was greater, some pressure in cardiac region, head confused, anorexia, which lasted 2^ h. — 17th, 9 a.m., 6 dr. in water. Again the pains in throat, some vertigo, pressure in gastric region, less malaise.— 19th. 10 dr. tinct. in water. At first slight pain m throat, hut after lO m. violent burning and scraping in fauces and palate, then nausea, worst in room, confusion of head, later pain in temples and forehead and above eyes. Then pressure in scrob. cordis, hard pulse. Later, flickering before eyes, furred tongue. These symptoms lasted 3 or 4 h., the flickering before eyes continued next d. Two d. later slight epistaxis, L. leg for several e. swollen down to ankle. — Sept. isi, 8.30 a.m., 14 dr. In } h. burning in throat, pressure in gastric region, malaise, weakness uf knees, heat in mouih and throat, eructation, pain in forehead and temples, astringent and rough taste, ill-humour, laziness, no feeling of hunger or thirst, some salivation. Slight swelling of 1. (varicose) leg. — 18th, 8.30 a.m., 20 dr. in water. After 10 m. scraping in throat, palate, oesophagus, and tongue, increasing for i h., continuing at same degree for i\ h., with heat and hot breath. From the first nausea, pressure in scrob. cordis, pain in temples and supra-orbital region. Eructation, yawning, weariness of legs, drowsiness when sitting and reading. All symptoms gone by 3 p.m. On standing for a considerable time 1. leg down to ankle swollen, especially e. — 24th, 8.45 a.m., 21 dr. in water. Immediately warmth in mouth, 5 m. later heat and scraping in fauces ; fell asleep in another 4 h. Tendency to nausea, temporal and frontal headache, pulse hard, slight salivation. Noon, the pain in throat better but there is great roughness in throat, confused head, vertigo, much pale urine, some flatulence, Swelling of 1. leg e.

(7W., 53.)

1. Dr. WuRSTL, a;t. 30. — Sept. 5th, lO a.m., 10 dr. tinct. At first agreeable coolness on tongue. After ^ h. prickling at back of

)palate and base of tongue, then feeling of warmth in the parts and dryness of tongue, which increased tu heat and burning. The burning

increased 80 that i( felt as if he bad been chewing pepper, not relieved by drinking cold water. Later the burning involved the tip of the tongue, the inside of lips, checks and gums. The skin, especially of face, perspired. Latei; heaviness of head, frequent eructations without ftwie, frei^ucnt discharge of flatus, weariness of lower limbs all d. After 3 h. the burning and dryness of mouth went off. When eating feeline Ol Mircncss of the affected parts, E., confuted head. — 6th, roam., lo ir^ Same symptoms as yesterday. — 7th, 10 a.m., 10 dr. In addition 10 bttrailkg ill throat and mouth, after i h. great anxiety, nausea, empty tmctMkim, moist cool forehead, oppression, rigor, trembling of hancfs mhA «Ul|in(| to stool at an unusual time. Little appetite for dinner. TWsr »TWptonw continued lill 6 p.m. N. restless. — loth, 10 a.m., 10 4u 1 M same burning feeling in throat. Noon, recurrence of the and anxiety. — iith, 10 a.m., 15 dr. 3 p.m., heaviness of TW Uirning m throat to-day was more vvere. E., headache extrftorjiuarv weariness and anxiety, trembling of limbs and fr*M mtloMMSt. Appetite bad.— I2th. 10 dr., same symptoms as felt swullen and as if its papillz were corroded by . — ijih, 14th, 15th, m., lodr. Always the same Ily confused head, vertigo, tinnitus aurium, harder tM«Hn4S.—3c<h, 3 1 St, and 22nd took 10 and 15 dr., which «Mm4 fmcMy the same symptoms. [Ihi^.y 5+.)

IJ. «> Dr« LCMBKI, Dec. 30th, 1867, 8.30 a.m., took 2 dr. 1st dil. No «^fe«* — .Un. 3rd, i8ft8, 8.30 a.m., 5 dr. No effect.— 4th, 8.30 «.m., 10 dr, and 3.^0 p.m., 10 dr. — 5th. Five liquid stools, preceded W puin in umbilKraT region and straining. — 6th, 4 p.m., 10 dr. — 7th. Sevemt soft stools during d.— 8th and 9th. Soft stools m. and noon. — ^tli, 4 |y.m., 10 dr. IVday and on loth and nth 2 soft scouls ^j,.>». _i ?iK,S*,m., ijdr. After every dusc there was long-continued ^1 taucc«, \Vhcn the subsequent larger dose was taken this

Wning wKti «o«Mtiincs aK>ut 2 h, — 13th, 4 p.m., 15 dr. Two ^^09k VIOolk No f«Ttli«r cAects fr>m this dil.

#, jMk iMk K«^ a,m., to dr. ist dec. dil. Smarting on tongue

Mi4 1^ OtMttMit »crap«n^ and burning in fauces and warmth in

«|y««»M\Hh< fMAlWl ^wing Ml flMJuldcrs and knees. — ]7th, 3.30 p.m.,

t| ^-t ImiwAMtlyx kmjt*«>ntinucd dull pain in stomach. Pressure

^ t, IMiiM- — ititK V<3^ a,m., 20 dr. Severe smarting and burning

tub KilWW< % prtvmrt^an r, «capula, above r. ear, in I. wrist. 3 p.m., 20

4k ^^ M pcctvMnkl ftmi «lorsal muscles of r. side, e. — 19th, 9 a.m.

«iiJl $ yvM>4 to4i. — *0(K 0 «*m., ao dr. Two soft stools. 8 p.m.,

*^ A, K«mM«>J IV<MH|| m I. «Mle of head i pressure in r. foot and in

liafWJte. UttM yWMOIW mi UonMCh lasting 2 h., with nausea and flow

V# ^fti^^ A« Usj<d ^cn. And a|»lii at 5 p.m., soft stool. Continued

^ 'n^jmU^^k A^ain on waking next m., unaffected by

V^>s<Ms^ v« WM» ^-<«%<if«> wwi» when at rest. — 2i»t, m., soft

«^«^t t««i^ M Kw^imJI ami ankles. Noon, soft stool. 5 p.m.,

If^- ^m 4mmk WWclcti r. «AKHlidcr-}oint painful all d. — 23rd,

^f, * 1>4#^ Ui r. mh o/forebcid, over head, and in face

M , 20 dr. Tearing in knees . . f»g above eyes, in r. toes, in

tibiz. — 25th, 6 and 8 a.m., 20 dr. Tearing in muscles of 1. upper arm, above r. and L knee when walking at 9 a.m., in r. elbow. Repeated feeling of heat in stomach, boring in r. sole, in calves. 3 p.m., 20 dr. Boring in 1. side of frontal bone, in r. shoulder, repeatedly. 5 p.m., tearing in toes, chilliness in back, cold hands, constant boring in wrists and ankles, in r. shoulder, worse when at rest. — 26th, 6.30 and 8 a.m., 20 dr. Pains as yesterday in shoulders, upper arms, wrists. Tearing in forcheadj occiput, knees. 3 p.m., 20 dr. 5 p.m., tearing in elbows and calves, — 27th, 6 a.m., 20 dr. 7 a.m., pressure in shoulders, wrists and ankles, tearing in forehead when sitting, repeatedly. 8 a.m., 20 dr, Frequent tearing in tibiae, fingers and toes. Up to now 2 soft stools daily. Drawing in nasal bones, dorsal muscles, 1. scapula, wrists. AH d. violent pain in tibiae, even when walking. 2 p.m., soft stool. 4 p.m., 20 dr. The same feeling all d., not atn. — 2yth, 7 a.m., 20 dr. Tearing in 1. tibia, forehead, 1. wrist, I. knee, shoulders, toes, nasal bones, head, Hngers, lumbar muscles. 8.30 a.m., 20 dr. Same symptoms. 2 p.m., copious liquid stool. — 29th, 6 a.m. in bed, tearing in tibix, not at n. 6.30 a.m., 20 dr. Tearing in toes, lower jaw, shoulders, legs, lumbar muscles, knees when sitting. Drawing on both sides of nose, wrists and Angers. 8 a.m., liquid stool. 8.30 a.m., 20 dr, Drawing in above parts. The worst pain is the tearing in tibiae,

9 a.m., liquid stool and discharge of fluid blood without pain (is not subject to piles). 4 p.m., 20 dr. Same pains. — 30th, 6.30 and 8.30 a.m., 20 dr. Same pains. 3 p.m., 20 dr. The worst pains are those in tibia, both sides of nose, heels, forehead. — 31st. Tearing in head in bed, m. 8.30 a.m., 20 dr. Tearing in 1. side of nose, in arms, knees. 4 p.m., 20 dr. During all this d. there was a short dry cough, with tickling in larynx, both n. and d. To-day this cough was very frequent, but the symptoms in legs were less frequent. 5 p.m., 20 dr.

10 p.m., severe boring in tibiae and nasal bones. At n. pain in 1. shoulder and much dry cough. — Feb. 1st, 6.30, 8 a.m. and 3 p.m., 20 dr. The former pains, 2 loose stools. — 2nd, 6.30 and 8 a.m., 20 dr. The same symptoms in limbs and head, dry cough. 4 p.m., 20 dr. Same symptoms. — 3rd, 6.30 and 8, 20 dr. The same symptoms, also smarting in edges of eyelids. No stool to-day. 4 p.m., 20 dr. On awaking at n. severe tearing in r, side of head several times. — 4th, 6.30 and 8 a.m. and 4 p.m., 30 dr. Same symptoms all d. A firm stool. — 5th. Woke at 6 a.m. with constant pressure and drawing in sinciput. 6,30 a.m., 30 dr. Severe drawing in legs when standing. 8 a.m., 30 dr. 9 a.m., great chilliness and very cold hands, pains in limbs as before. A firm stool. 3 p.m., 30 dr. All d. the former symptoms i especially severe was the boring in tibiz, particularly 1. Also some boring-drawing pains in temples, fingers and their joints, ankles, bones of feet. Cough less.— 6th. On waking at 6 a.m. the same headache as yesterday. Took then 30 dr. 6.30 a.m., boring and drawing in toes, kneeSj forearms. Constant pressure in stomach. 8 a.m., 30 dr. Boring and drawing on 1, side of forehead, I. temple, repeatedly. 9 a.m., drawing in legs, near nose, great pressure in knees when at rest. Great boring above ankles, tibiae, in shoulders, above knees, in 1. lower jaw. P'irm stool. Drawing in muscles and skin of

TOL. III. ao

thighs. Pressure in stomach repeatedly. Pains felt when walking.

3 P*"!., 30 dr. Above symptoms and boring in 1. upper maxilla and dorsal vertebrae when sitting. — 7th. After waking, in bed, boring in 1. upper arm, r. thumb-Joint, I. ankle-joint, r. temple. 6.30 a.m., 30 dr. Frequent boring in dorsal vertebrx and head in several parts. Above pains in wrists and fingers. 8 a.m., 30 dr. Pains as yesterday in thigh-muscles, boring in shoulders. Itching and snurting in border of eyelids, on skin near nose. 8.30 a.m., chill over back, cold hands, boring in ankles, 1. lower maxilla, shoulders, tibiz. Firm stool. Burning and itching in 1. eyebrow. When walking boring in 1. shoulder-joints and wrists, weariness in legs. Boring above 1. eye and in nasal bones. 8 p.m., 30 dr. Boring m knees and bones of head. All former symptoms recur. Burning in skin of r. cheek and 1. calf. — 8th. In bea pains like yesterday. 6.30 a.m., 30 dr. Same symptoms,

8 a.m., 30 dr. Firm stool. Jerking boring in cranial bones, especially on top of head. 4 p.m., 30 dr. Same boring in skull. Repeated severe shooting in pectoral muscles on inspiration, while sitting, the same under 1. short ribs near spine. Very frequent boring in knees, wrists, behind ears, when walking and sitting, all d. Burning and shooting in skin of r. axilla at 10 p.m. — 9th, 0.30 a.m., 30 dr. Same symptoms. 8 a.m., 30 dr. Firm stool. Persistent pressure in stomach. 3 p.m., 30 dr. Stitches under 1. false ribs. Same symptoms as yesterday. 8 p.m., persistent burning and smarting at back of nose.

9 p.m., pressure in knees when sitting. Persistent burning in upper lip and below 1. eye. Great boring in r. side of cranial bones at 10 p.m.

c. Feb. loth, 7.30 and 8 a.m., 3 dr. tinct. in water. 8.30 a.m., severe and persistent burning in skin of r. cheek. Recurrence of previous symptoms in limbs, face, and head. Firm stool. The burning in cheek frequently recurs. 3 p.m., 3 dr. Similar burning in alx nasi. E., slight drawing in urethra. — nth, 6.30 and 8 a.m., 4 dr. Much boring behind r. ear. Firm stool. 3 p.m., 4 dr. Return of same symptoms, especially boring in r. hip-joint, bones and toes of L foot^ r. tibia. — i2th. Before taking the med., boring and pressure in 1. ankle-joint, forehead, cranial bones, knees. During n. for a long time dull pressure in stomach, 6.30 a.m., 4 dr. 7.30 a.m., the symptoms in cranial bones, shoulders, foot-bones, stomach, continue. Burning in r. cheek and 1. calf. 8 a.m., 4 dr. Same symptoms. 3 p.m^

4 dr. Same symptoms. 5 p.m., great burning in skin of 1. cheek u from a hot body. — 13th, 7 a.m., 5 dr. Boring in tibiae, wrists, hipjoints, burning in r. side of nose, dry cough, pressure in stomach, pra* sing above ankles. Burning in skin of r. temple, extending to r. cheek. 8 a.m., 7 dr. Recurrence of burning in r, cheek. Severe and persistent drawing and pressure in r. forearm and 1, toes. Tearing in cianial bones, r. side. Burning near alx nasi, on skin of r. shin, upper lip« Drawing pressive pains in dorsal muscles, in different parts or limbSp especially bones of feet and hands, fingers \ boring in various parts of hand, worst when at rest. — J4th, m., in bed ^ring in shoulders. After rising, same symptoms, and burning in r, cheek and 1. palm. Pressure in knees, boring in tibise and shoulder-joints. Pressure in muscles of thighs, in foot-bones, fingers, toes, and ankles* Burning in

parts of skin as yesterda^} also in skin of nape. Great burning in 1. trochanter. — 15th to 19th Feb. The same symptoms continued with varying intensity, though no med. was taken. On the 22nd all symptoms were gone. — 23rd, 3 p.m., 6 dr. After i h., drawing boring pains in arms, knees, ankles, bones of head, and feet, 5 p.m., severe boring above ankle and wrist. 7 p.m., burning in r. cheek and 1. tibia. Boring and tearing in 1. side of forehead towards temple repeatedly, then the same in occiput. Burning and shooting in skin of inside of 1. upper arm. Great pressing in lower part of 1. forearm, in knees. Boring in tibiae, ankles, and bones of foot. 10 p.m., severe boring in cranial bones, also in bed. No pains at n. — 24th. On rising, m., boring in I. ankle, toes, shoulders. 8 a.m., 10 dr. Boring behind r. car. Wandering pains in lumbar region and occiput, shoulders, back of thighs, various parts of head. Burning in skin of legs in several places. Smarting in borders of eyelids. Noon, persistent pressure and drawing in r. elbow-joint, relieved for a short time by moving joint. Later, same pain in r. wrist and finger-joints. 3 p.m., 10 dr. 4 p.m., constant boring in 1. side of forehead and in knees when sitting. Burning in skin of forehead. Drawing and pressure in usual places all d. more or less. Drawin? pains in various places of soft parts of arms and legs. — 25th, 8 and 12 a.m. and 3 p.m., 10 dr. Repetition of almost all the previous symptoms. — 26th, 6 and 8 a.m. and 4 p.m., 10 dr. Similar symptoms, and in addition severe cutting in orifice of urethra after urinating at 9 a.m., and also later. Soon after 4 p.m. dose, severe and protracted burning in skin of r. cheek, on tip of nose, and nasal partition. 5 p.m., burning and boring in 1. cheek and tip of tongue. — 27th, 8 a.m. and 3 p.m., 15 dr. All d. much the same effects. Two stools, with the stool in e. much bright blood. Some cutting in end of urethra. — 28th. On rising, m., boring in dorsum of feet, tibia; ; drawing in legs^ cranial bones, arms, and loins ; boring in forehead. 6.30 a.m., 15 dr. Most of previous symptoms, and, in addition, at 7.30 persistent prick in tip of 1. big toe as if a needle were bored in. Great drawing in knees and legs while sitting, with bruised and tired feeling. Pricking in various parts of skin of 1. palm and in finger-tips as with needles. 8 a.m., boring in bones of occiput, and superior maxilla and shoulders. Discharge of fluid blood with stool. Shooting below 1. axilla betwixt ribs. Burning in skin oninsideof r. thigh and scrotum with slight itching. Burning in alx nasi. 3 p.m., 15 dr. Most of previous symptoms. 6 p.m., 15 dr. Besides former symptoms, there was shooting in end of urethra and frequent call to urinate, though he had just passed urine. Occasionally when sitting some irregular heart's beats, repeated at n. when lying on back. — March ist, 9 a.m., insufficient stool with bright blood. All d. the usual symptoms except the pain in urethra. [N. Z./. h, KI.^ xiii, 35.)

1. The preparation employed in provings 16 — 19 was a tincture made of one part of the juice of the bark with 4 parts of spirits of wine. P — r, M.D., ast. 23, took in the beginning of May, 6 dr., then after 4 d. 18 dr., and observed the following symptoms during 12 d. Digestive 0r^0fl/.— Roughness and burning pain in cesophagus (after a few m.), aggravated when expiring with mouth open. Burning all through

mouth, relieved by eating, but frequently recurring (ist d.) After a second larger dose, same pain but less severe, going ofF after i h. Burning in oesophagus when water is swallowed. Nausea and eructations after i h. Dislike to meat, otherwise good appetite. Great thirst (from 1st to 4th d.). Distension of abdomen. Cutting and twisting in bowels. Urinary and genital organs, — Pale urine, passed only once or twice a d. — usually 6 or 8 times (from ist to 4th d.). Viscid, transparent fluid adheres to orifice of urethra (forenoon of 9th d.). Pressive pain towards inguinal ring, frequently. Respiratsrj organs, — Pressive pain in 1. side of chest. Skin. — Brownish miliary rash on chest, upper arm and thighs (3rd d.) Vesicles full of clear serum on back of nose ^ inflamed skin under burst vesicles ; a brown scab forms. Roughness of skin, here and there desquamation. Extremely tiresome itching in a wound soon after it has healed. Fibrous structures and bones. — Tearing pains deep in both arms as if in the bones. Increased warmth and pulsation in r. shoulder. Pressive pain in r. heel-bone. Pain in a carious tooth, m. Vascular and nervous systems. — Vertigo (after i h.). Boring pain in I. half of forehead. Pallor of face, considerable collapse of face and extremities. Extraordinary paresis of flexor muscles of fingers (from 3rd to 5th d.). White shining spots before eyes. General sensibility. — Chilliness, especially e. Great laziness and exhaustion after deep sleep. Disposition. -^-Qros^ humour, disinclination for work. {A. h. Z., xiv, 113.)

1. E — d, M.B., xt. 23, took, middle of February, ist d. i, 2nd d. 2, 4th d. 3 dr. in a large quantity of water ; secondly, middle of March, ist and 2nd d. 4, 8thd. 12 dr. on sugar. Digestive organs.'^ Burning pain in oesophagus for some h., increased by inspiration. Difficulty of swallowing with sensation as if a foreign body stuck in oesophagus (from 7th d., lasting several d.). Increased secretion of saliva, and afterwards alkaline, salt taste, with metallic, fetid odour from mouth. Constant desire for food. Respiratory or^aRj.— Inflamed state of windpipe with violent burning pain betwixt tongue-bones and thyroid cartilage, somewhat relieved by eating (from 6th to 9th d,). Skin, — Almost everywhere on skin great itching, now in neck, now on chest, now on extremities, compelling scratching and then jumping to other parts, especially towards e., for several weeks. Burning itching and tension on posterior aspect of lobe of I. ear ; on scratching the epidermis comes off in shreds i inch in size. Fibrous structures andbones. — Formication in big toes (for 8 d.) recurring every n, and disturbing sleep. Once a similar sensation in phalanges of fingers, as if proceeding from surface of bones. Tearing pain in thighs and tibise. Fascular and nervous systems. — Confusion of head. Pressive pain in region of r, parietal bone, as though the brain were pressed against the skull, the pain increased by leaning head towards r. ; this pain frequently recurred and was the most constant symptom, and was still occasionally felt after 8 weeks. Pressive pain in eyeballs as if they were too big. Shocks through whole body when waking and sleeping. General sensibility,— Chilliness and shivering towards e. Dreamful, restless sleep, disturbed, by formication in fingers. — Disposition. — Crossness. (Ibid.^ 115.)

2. G — r, medical student, £t. 27, troubled with rheumatism, took

in March 5 dr. and observed symptoms for 8 d. Digestive organs. — Burning in oesophagus, rising upwards, immediately ; nausea, shortly afterwards amounting to inclination to vomit ; tasteless eructations. Increased (low of saliva of sweet taste. Constant hunger with feeling of emptiness in stomach. Urinary organs, — On urinating slight itching in urethra. Vascular and nervous systems. — Shooting pain over r, eyebrow (after | h.). General sensibility. — Constant chilliness, desire to stretch. Restless sleep full of dreams. Disposition, — Crossness. {Ibid,^ 1 16.)

1. T— e, M.B., act. 24. In the end of March took daily increasing doses up to 24 dr. Digestive organs. — Burning pain in fauces, extending to angles of mouth and lips, where the skin desquamated. Increased flow of saliva of salt taste, carious odour of mucus on lower incisors. Teeth sometimes feel on edge and too long. Slight nausea and pressure in stomach. Rumbling in bowels whilst and a^er eating. Itching in anus, like tenesmus (from ist to 4th d.). Urinary and genital organs. — Frequent pale urine, also n. (from 3rd to 8th d.). Prcssive drawing pains in spermatic cord, frequently ; pain in both testicles when pressed. Respiratory organs. — Frequent sneezing (5 d.). Nasal catarrh with discharge of thin mucus, which makes nostrils sore, and sometimes in the m. has streaks of blood. Cough, at first dry, with feeling of soreness under sternum and tensive headache, afterwards copious expectoration of mucus. Skin. — Burning itching, especially in nape and calves. Burning, red, miliary pustules on thighs. Burning vesicles surrounded by red areola on sides of fingers, rather sticking in the skin than raised above it. They dry up, and leave behind them either bright red spots or the epidermis scales off in round flakes. Shooting pains in a cicatrix on tip of r. middle finger, in which there had been no sensation for 2 years. Fibrous structures and bones. — Shooting pains in scapula;, especially p.m., for several d. Fascular and nervous systems, — Pressive pain in temples (after 2 h.). Headache, as if the brain, hanging loose in skull, knocked here and there on the walls of the skull when the head is moved (from 8th to 12th d.). Pressive pain in eyeball and eyelids, especially in bright light. Frequent twitching and gnawing in muscles of zygoma on r. side. Genera) sensibility, — Shivering, e. {Ibid^ 116.]

2. I took at various times some dr. of x,, 3X, and jx dils., and once some drops of linct. Many M. symptoms were confirmed. I will at present mention only those of the skin : Oft-recurring severe itching, compelling to scratch, now here, now there, on almost all parts of body, and very soon after taking drug; especially on scalp above forehead, in one or other eyebrow, also under eye j and especially persistent and frequent in I. external ear. It often extended over whole body, so that I felt it simultaneously on back, abdomen, and scalp, impelling to scratch, and relieved by scratching. I could perceive no difference in the time of d. The later the itching began, the greater the inclination to scratch. Smarting in eyes, compelling to rub them. Violent stitching and burning itching on outer aspect of r. shoulder, as if in flesh, as though an eruption would appear there. (Gerstel, Trans. oflVorlits Horn, Conventiony i, 163.)

II. Poisonings, — I. A girl of 14 rubbed juice of leaves upon her

cheeks and the adjoining parts. There followed burning pains ; swell* ing of face, especially of nose, eyelids, and forehead, like an erysipelas bullosum (on cheeks the blisters became confluent) ; continual, violent, and painful sneezing, and complete closing of nostrils -, delirium ; dull, intolerably pressive pains in forehead ; disagreeable dryness in fauces, and irritation causing dry fatiguing cough; febrile pulse; burning and red urine. After cooling and emollient applications burning and swelling subsided, and epidermis peeled off. Then set in weakness, low spirits, and listlessness, to such an extent that she was almost imbecile. (She was later attacked with typhus, followed by hectic, of which she died.) (Pluskal, Ofst, SFochenschr.^ 1844,)

1. A robust farmer who was affected by haemorrhoids swallowed, for obstinate constipation, 40 ripe berries of M. Next m. the doctor found him quite prostrate, in violent pain, with vertigo, embarra$6ed feeling in head, pale, cold, and sunken countenance, dilated pupils, unquenchable thirst, violent burning in mouth, fauces, oesophagus, and stomach, which, with whole abdomen, was exceedingly painful on slightest touch. During n. he had vomited unceasingly, and had almost continual evacuation of bowels, stools at last consisting of bloodv. mucus. Voice was altered, weak, and trembling ^ breathing oppressed,^ laboured, and short ; sweat abundant and cold ; extremities cold \ urine acrid and blood-red ; pulse very frequent, unequal, hard, and tense. It was 4 weeks before he could apply himself to any work* (Ibid,, 1843.)

2. An otherwise robust man took M. internally for some complaints that he had. But as, after the disappearance of these, he still continued the use of this drug, he became affected with an intolerable itching over the whole body, which did not allow him an hour's sleej He left off the medicine, came to me 36 h. afterwards, and assur< me he could no longer endure the itching, which increased every h. It went off gradually under camphor. (Hahnemann, Ltsstr Writings^ p. 381.)

Volume IV — Appendix

MEZEREUM.

(See vol. ill, p. 193.)

1. 1. On July 7th, at 6 p.m., I saw a child of 4, who ha^ several berries of M. 2 h. before. She had had a convulsion shoi before being brought to the surgery, but at this time there were other symptoms. On exhibiting an emetic the child vomited fre< and brought up two nearly whole berries, and a quantity of fragmf probably representing 2 or 3 more. As the child showed no \ marked symptoms, she was sent home, where at 9 p.m. I saw again. At this time the irritant poison displayed itself in swollen i tongue furred and swollen to about twice its normal size and proti ine beyond the lips, great difficulty in swallowing, extremities c< pulse 130 and very weak, I ordered demulcents and castor-oil.

latter acted freelv, getting rid of some half-dozen berries ; and next m. diUd was coiiTalincent, and all si^ns of irritation had disappeared save that tongue was quite raw (glycerine had been applied to it). (Eagar, Brit, AM. Jntm., 1887.)