Antipyrinum

(ANTIPYRINE)

Antipyrine is one of the drugs that induce leucocytosis, similar to ergotin, salicylates, and tuberculin. Acts especially on the vaso-motor centers, causing dilation of capillaries of skin and consequent circumscribed patches of hyperæmia and swelling. In large doses causes profuse perspiration, dizziness, cyanosis, and somnolence, albumen and blood in urine. Acute erythema multiforme.

Mind

Fear of becoming insane; nervous anxiety; hallucinations of sight and hearing .

Head

Throbbing headache; sensation of constriction . Flashes of heat. Headache under ears with earache .

Eyes

Puffiness of lids. Conjunctiva red and œdematous, with lachrymation . Red spots ( Apis ).

Ears

Pains and buzzing. Tinnitus .

Face

Œdema and puffiness. Red and swollen.

Mouth

Swelling of lips. Burning of mouth and gums. Ulceration of lips and tongue; vesicles and bullæ. Small lump in cheek. Tongue swollen. Bloody saliva. Toothache along lower jaw.

Throat

Pain on swallowing. Expectoration of fetid pus. Abscess, white false membrane. Sensation of burning.

Stomach

Nausea and vomiting; burning and pain.

Urine

Diminished. Penis black.

Female

Itching and burning in vagina. Menses suppressed. Watery leucorrhœa.

Respiratory

Fluent coryza. Nasal mucous membrane swollen. Dull pains in frontal sinus. Aphonia. Oppression and dyspnœa. Cheyne-Stokes respiration.

Heart

Faintness, with sensation of stoppage of heart. Throbbing throughout the body. Rapid, weak, irregular pulse.

Nerves

Epileptiform seizures. Contractures. Trembling and cramps. Crawling and numbness. General prostration .

Skin

Erythema , eczema, pemphigus. Intense pruritus . Urticaria , appearing and disappearing suddenly, with internal coldness. Angioneurotic-œdema. Dark blotches on skin of penis, sometimes with œdema.

Dose

Second decimal potency.